CN104800132B - A kind of preparation method of cloves compound mouthwash - Google Patents
A kind of preparation method of cloves compound mouthwash Download PDFInfo
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- CN104800132B CN104800132B CN201510249966.3A CN201510249966A CN104800132B CN 104800132 B CN104800132 B CN 104800132B CN 201510249966 A CN201510249966 A CN 201510249966A CN 104800132 B CN104800132 B CN 104800132B
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Abstract
The present invention provides a kind of preparation method of cloves compound mouthwash, comprises the following steps：Sweetener, acid and essence are stirred to dissolving in water, then NMF and food antiseptics are added in sterilized water, the transparent finely dispersed aqueous solution is stirred to clarify；Prepare eugenol mother liquor；Prepare tea polyphenol mother solution；Prepare pseudo-ginseng mother liquor；It is fluorinated the preparation of mother liquid of sodium；Above-mentioned four kinds of mother liquors are mixed, and add PEG 40, active component mother liquor in mouthwash is obtained；Under stirring, the aqueous solution is slowly added in active component mother liquor, stopped after stirring, overnight stand, is filtered, finished product is obtained after aseptic process.The inventive method is simple, strong operability, suitable for industrialization production.
Description
Technical field
The present invention relates to it is a kind of using cloves, Tea Polyphenols, pseudo-ginseng as the multifunctional pure natural mouthwash of primary raw material preparation
Method and purposes, belong to mouthwash field.
Background technology
With the continuous improvement of today's society living standard, also gradually changing again for people's eating habit is added usually not
Good habits and customs, thus emerge many oral problems, such as periodontitis, carious tooth, halitosis and canker sore.Mouthwash is section
The pharmaceutical compositions in a variety for the treatment of oral cavities, pharyngolaryngitis are engaged and develop and can directly make by the novel product in skill epoch, researcher
For site of disease, can also remove because of mouth disease, eat peculiar smell foodstuff, dyssomnia, stress, indigestion etc. caused by halitosis
Mouthwash.Traditional mouthwash contains more alcohol, there is certain harm to oral cavity, and portioned product is to reach ideal effect,
Do not stint addition chemical synthesis reagent, to improve the effect of mouthwash, and this way, there is very big safety for user
Hidden danger.Current new plants essential oil class gargles water constituent naturally, with permeability is strong, non-specificity is sterilized, acted on soon, effectively
The characteristics of long action time, Small side effects, and oral care product field has been widely used at home.In addition natural traditional Chinese medicine
Composition has some other bioactivity, can strengthen body immunity, plays the role of to prevent and treat cancer.
The development of the domestic this kind of mouthwash to the composition containing natural Chinese medicinal herb is seldom at present, existing Patents, some
Composition is excessively single, and some lack corresponding experiment, it is impossible to ensure the security of mouthwash.
The content of the invention
It is an object of the invention to provide a kind of preparation method of cloves compound mouthwash.
A kind of preparation method of cloves compound mouthwash, comprises the following steps：
1) sweetener, acid and essence are stirred in water to dissolving, then NMF is added to food antiseptics
In sterilized water, the transparent finely dispersed aqueous solution is stirred to clarify；
The sweetener, acid, essence, NMF, the weight ratio of food antiseptics are 0.01~1：0.02~1：0.5
~1：2~10：0.01~0.4；
2) eugenol mother liquor is prepared：Sterilized water is added into eugenol, 30-50 DEG C is heated to, PEG-40 is added, stirred molten
Solution is extremely clarified；Obtain 40mg/mL eugenol mother liquor；
Prepare tea polyphenol mother solution：Sterilized water, stirring and dissolving to clarification are added into Tea Polyphenols；Being prepared into ultimate density is
40mg/mL tea polyphenol mother solution；
Prepare pseudo-ginseng mother liquor：To Notogineng Extract (20:1) sterilized water, stirring and dissolving to clarification are added in；It is prepared into final
Concentration is 20mg/mL Notogineng Extract mother liquor；
It is fluorinated the preparation of mother liquid of sodium：Take sodium fluoride to be dissolved in sterilized water, be prepared into the sodium fluoride that ultimate density is 10mg/mL
Mother liquor；
3) above-mentioned four kinds of mother liquors are mixed, and adds PEG-40, obtain active component mother liquor in mouthwash；
Tea Polyphenols, eugenol, Notogineng Extract, fluoride, PEG-40 weight ratio are in the active component mother liquor：
0.2~0.4：0.5~1：0.17~0.2：0.05：3~6；
Under stirring, by step 1) in the aqueous solution be slowly added to step 2) in configuration active component mother liquor
In, stop after stirring, overnight stand, filtering, finished product is obtained after aseptic process.Wherein, the weight ratio of Tea Polyphenols and sweetener is
0.2~0.4：0.01~1, the concentration of Tea Polyphenols is 2~8mg/mL.
Further, in the above-mentioned technical solutions, described sweetener is selected from saccharin sodium, D-sorbite, xylitol, fruit
One or more in sugar, stevioside glycosides.
Further, in the above-mentioned technical solutions, the acid in malic acid, citric acid or tartaric acid one
Kind.
Further, in the above-mentioned technical solutions, the NMF uses glycerine or sorbierite；The essence uses peacock
Essence, menthol.
Further, in the above-mentioned technical solutions, the essence uses peacock essence, menthol.
Further, in the above-mentioned technical solutions, the food antiseptics is the golden ester of Buddhist nun's pool second.
The invention provides the purposes of above-mentioned mouthwash, the mouthwash can be used for treating or preventing periodontitis, carious tooth, mouth
The mouth diseases such as smelly, canker sore, have effects that to brighten, are good for tooth, clearing heat for detumescence, pre- anti-cancer.
The application method of this mouthwash：Take this product appropriate, about 10-20ml, containing gargling about 2-3min, discharge.
Invention beneficial effect
Eugenol in the present invention has inhibitory action to malignant bacteria and fungi, also anti-with antioxidation and necessarily
Cancer is acted on, and smell is unique, and the antibacterial of Tea Polyphenols, antioxidant effect are also very good, are widely used in toothpaste, pseudo-ginseng tool
There is stronger anti inflammatory blood quickening effect, have fine inhibitory action to the main harmful bacteria in the resident bacteria of oral cavity.The present invention by it is a variety of into
Point combine, in addition to the function in the cleaning oral cavity with different mouthwashes, also with treat or prevent periodontitis, carious tooth,
The mouth diseases such as halitosis and canker sore, brighten, are good for tooth, clearing heat for detumescence, effect of pre- anti-cancer.With a variety of preventing and treating oral cavities disease
Effect of disease.This mouthwash uses natural plant composition, has more preferable security than the mouthwash on existing market.Present invention side
Method is simple, strong operability, suitable for industrialization production.
Brief description of the drawings
Fig. 1 is the mouthwash of embodiment 1 to staphylococcus aureus, Escherichia coli, bacillus subtilis, Candida albicans
Inhibition figure；
Fig. 2 is inhibition figure a of the mouthwash of embodiment 1 to Oral Bacteria；
Fig. 3 is inhibition figure b of the mouthwash of embodiment 1 to Oral Bacteria.
Embodiment
Following nonlimiting examples can make one of ordinary skill in the art be more fully understood the present invention, but not with
Any mode limits the present invention.Eugenol, is purchased from the oily Co., Ltd of Jiangxi deodar natural medicinal plant, density 1.063-
1.068g/ml；Tea Polyphenols, is purchased from the careless plant Trade Co., Ltd. in Xuancheng hundred；Notogineng Extract (20：1) it is purchased from Baoji Fang Sheng
Biological development corporation, Ltd..
Embodiment 1
Preparation method, by taking 100ml production as an example：
(1) preparation of active ingredient mother liquor,
The preparation of eugenol mother liquor：3.756ml eugenols (ρ=1.063~1.068g/ml) are taken, first add on a small quantity sterile
Water, is put into magnetic stirring apparatus and heats while stirring, and heating-up temperature is 40 DEG C, is gradually added into PEG-40 (6~10ml) to solution
Clarification, is supplemented distilled water to 100ml.It is prepared into the eugenol mother liquor that ultimate density is 40mg/mL.
The preparation of tea polyphenol mother solution：Take 4g Tea Polyphenols to be dissolved in 100ml sterilized waters, be prepared into ultimate density for 40mg/mL
Tea polyphenol mother solution.
The preparation of Notogineng Extract mother liquor：Take 2 Notogineng Extracts (20:1) it is dissolved in 100ml sterilized waters, is prepared into final
Concentration is 20mg/mL Notogineng Extract mother liquor.
It is fluorinated the preparation of mother liquid of sodium：Take 1g sodium fluorides to be dissolved in 100ml sterilized waters, be prepared into ultimate density for 10mg/mL
Fluorination mother liquid of sodium.
(2) above-mentioned eugenol mother liquor 25ml, tea polyphenol mother solution 5ml, Notogineng Extract mother liquor 8.33ml, fluorination mother liquor are taken
5ml, is gradually added into PEG-401ml and is clarified to solution, can obtain active ingredient mother liquor mixed liquor with ultrasonic dissolution；
(3) 55.67ml sterilized waters are taken to add glycerine 5g, K120.5g, D-sorbite 0.01g, malic acid 0.02g, menthol
0.5g, nipagin esters 0.1g, it is stirring while adding to the finely dispersed aqueous solution of clear；
(4) under stirring, by step 1) in the aqueous solution be slowly added to step 2) in configuration active component it is female
In liquid, after being well mixed, stop after stirring, overnight stand, filtering, finished product is obtained after aseptic process.
Antibacterial test 1
Show the fungistatic effect of active component in mouthwash by determining the growth curve of bacterium, method is：Sterile behaviour
Make, fluid nutrient medium is prepared using the cloves compound mouthwash obtained in embodiment 1, and be not added with the fluid nutrient medium of active ingredient
Together, using blank cultures as control, initial OD values are determined under 600nm.8~12h of culture bacterium solution 3ml is taken again, is added to
State in fluid nutrient medium, then survey an OD value, as 0h OD values, determine an OD value every 2h later, survey after 8h, 24h again
Survey once, the OD values at each resulting moment subtract initial absorbance value, and it is bacterium to do a curve with these numerical value
Growth curve.
Inhibition to staphylococcus aureus, Escherichia coli, bacillus subtilis, Candida albicans is shown in Table 1 and figure
1：
Inhibition of the active component to different bacteria growings in the cloves compound mouthwash of table 1
Inhibition to Oral Bacteria is shown in Fig. 2, Fig. 3：Fig. 2 is inhibition of the mouthwash to bacterium in certain female oral cavity, and Fig. 3 is
Mouthwash is to the inhibition of bacterium in certain male oral cavity, and wherein negative control is the Liquid Culture in the physiological saline containing equal volume
The growing state of Oral Bacteria in base.
Claims (6)
1. a kind of preparation method of cloves compound mouthwash, it is characterised in that comprise the following steps：
1) sweetener, acid and essence are stirred in water to dissolving, then NMF and food antiseptics be added to sterile
In water, the transparent finely dispersed aqueous solution is stirred to clarify；
The sweetener, acid, essence, NMF, the weight ratio of food antiseptics are 0.01~1：0.02~1：0.5~1：
2~10：0.01~0.4；
2) eugenol mother liquor is prepared：Sterilized water is added into eugenol, 30-50 DEG C is heated to, PEG-40 is added, stirring and dissolving is extremely
Clarification；
Prepare tea polyphenol mother solution：Sterilized water, stirring and dissolving to clarification are added into Tea Polyphenols；
Prepare pseudo-ginseng mother liquor：Sterilized water, stirring and dissolving to clarification are added into Notogineng Extract；
It is fluorinated the preparation of mother liquid of sodium：Sodium fluoride is taken to be dissolved in sterilized water；
3) above-mentioned four kinds of mother liquors are mixed, and adds PEG-40, obtain active component mother liquor in mouthwash；
Tea Polyphenols, eugenol, Notogineng Extract, fluoride, PEG-40 weight ratio are in the active component mother liquor：0.2~
0.4：0.5~1：0.17~0.2：0.05：3~6；
Under stirring, by step 1) in the aqueous solution be slowly added to step 2) in configuration active component mother liquor in, stop
Only stir, after overnight stand, filter, finished product is obtained after aseptic process；Wherein, the weight ratio of Tea Polyphenols and sweetener be 0.2~
0.4：0.01~1, the concentration of Tea Polyphenols is 2~8mg/mL.
2. preparation method according to claim 1, it is characterised in that：Described sweetener is selected from saccharin sodium, D-sorbite, wood
One or more in sugar alcohol, fructose, stevioside glycosides.
3. preparation method according to claim 1, it is characterised in that：The acid is selected from malic acid, citric acid or winestone
One kind in acid.
4. preparation method according to claim 1, it is characterised in that：The NMF uses glycerine or sorbierite.
5. preparation method according to claim 1, it is characterised in that：The essence uses menthol.
6. preparation method according to claim 1, it is characterised in that：The food antiseptics is ethylparaben.
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| CN201510249966.3A CN104800132B (en) | 2015-05-15 | 2015-05-15 | A kind of preparation method of cloves compound mouthwash |
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| CN201510249966.3A CN104800132B (en) | 2015-05-15 | 2015-05-15 | A kind of preparation method of cloves compound mouthwash |
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| CN104800132B true CN104800132B (en) | 2017-09-08 |
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Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105616324A (en) * | 2016-01-27 | 2016-06-01 | 珠海迈润实业有限公司 | Mouthwash containing plant formula and preparation method thereof |
| CN108066166A (en) * | 2018-02-10 | 2018-05-25 | 广州市九科精细化工有限公司 | Remove acid mouthwash of calculus dentalis and preparation method thereof |
| CN108066167A (en) * | 2018-02-10 | 2018-05-25 | 广州市九科精细化工有限公司 | A kind of antibacterial whitening acidity mouthwash of visualization and preparation method thereof |
| CN108186441A (en) * | 2018-02-10 | 2018-06-22 | 广州市九科精细化工有限公司 | A kind of antianaphylactic compound herbal mouthwash of hemostasis and preparation method thereof |
| CN108096047A (en) * | 2018-02-10 | 2018-06-01 | 广州市九科精细化工有限公司 | Domiphen bromide xylitol combination of acidic mouthwash and preparation method thereof |
| CN108014024A (en) * | 2018-02-10 | 2018-05-11 | 广州市九科精细化工有限公司 | A kind of deep layer removes mouthwash of crock tea stain and preparation method thereof |
| CN108042383A (en) * | 2018-02-10 | 2018-05-18 | 广州市九科精细化工有限公司 | A kind of anti-inflammatory, antibacterial Domiphen bromide mouthwash and preparation method thereof |
| CN108014070A (en) * | 2018-02-10 | 2018-05-11 | 广州市九科精细化工有限公司 | Visualization propolis acidity mouthwash of hemostasis and anti-inflammation and preparation method thereof |
| CN108403544B (en) * | 2018-03-26 | 2021-09-17 | 长沙循源医学科技有限公司 | Oral care composition for children and preparation method thereof |
| CN108464965B (en) * | 2018-06-15 | 2021-07-23 | 沈阳药科大学 | Propolis mouthwash containing natural active ingredients and preparation method thereof |
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|---|---|---|---|---|
| JPS56110610A (en) * | 1980-02-06 | 1981-09-01 | Lion Corp | Composition for oral cavity |
| CN1034130A (en) * | 1988-07-23 | 1989-07-26 | 吴海元 | Child's preventing decayed tooth health gargle and method for making |
| GB2423251A (en) * | 2005-02-15 | 2006-08-23 | Louise Hagan | Tooth balm and mousse |
| EP2332514A1 (en) * | 2009-12-14 | 2011-06-15 | Henkel AG & Co. KGaA | Antibacterial oral and tooth care and cleaning agents with silver |
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Effective date of registration: 20210727 Address after: 528000 2-5A and 2-5b, floor 5, No. 2 plant, No. 20-1, Xingtang Road, Datang Town, Sanshui District, Foshan City, Guangdong Province (residence declaration) Patentee after: Guangdong Aimu Biotechnology Co.,Ltd. Address before: 230000 1511, c-office, Hongrui business center, No.9, Dongliu Road, Baohe District, Hefei City, Anhui Province Patentee before: Anhui Quanjing New Material Technology Co.,Ltd. Effective date of registration: 20210727 Address after: 230000 1511, c-office, Hongrui business center, No.9, Dongliu Road, Baohe District, Hefei City, Anhui Province Patentee after: Anhui Quanjing New Material Technology Co.,Ltd. Address before: 116622 No. 10 Xuefu street, Jinzhou New District, Dalian, Liaoning. Patentee before: DALIAN University |