CN104306268A - Oral care product and extraction method of composition - Google Patents
Oral care product and extraction method of composition Download PDFInfo
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- CN104306268A CN104306268A CN201410613108.8A CN201410613108A CN104306268A CN 104306268 A CN104306268 A CN 104306268A CN 201410613108 A CN201410613108 A CN 201410613108A CN 104306268 A CN104306268 A CN 104306268A
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Abstract
The invention discloses an oral care product. A composition comprises 4 to 10 percent of red ginseng extract powder, 4 to 10 percent of extract powder of the root bark of the peony tree and 82 to 90 percent of clove extract oil; in the care product, the weight percentage of the composition is 0.5 to 10 percent, the weight percentage of auxiliary materials is 90 to 99.5 percent and the care product has a dosage form of a toothpaste or mouth wash. According to the extraction method of the composition in the oral care product, firstly, the root bark of the peony tree and red ginseng are smashed and decocted; filtrate is added into ethanol to be distilled to obtain extract powder; then mixing the extract powder and clove extract oil. The red ginseng and the root bark of the peony tree in the oral care product disclosed by the invention are refined by adopting a method of preparing the extract powder by concentration and distilment; by refining, effective component content can be increased, other impurities are reduced and the incidence irritability is reduced while the medicine effect is improved; when the oral care product adopts the toothpaste or mouth wash dosage form, the curative effect of the composition can be improved, the storage time of the composition is prolonged and the oral care product is convenient for a patient to use; the formula of integrating the red ginseng, the root bark of the peony tree and the clove extract oil into one whole body has strong capacity of preventing and treating gingivitis, stomatitis, halitosis and gingival pain and also enables gingiva to be strong and healthy.
Description
Technical field
The present invention relates to field of oral care, be specifically related to a kind of product of compositions and the extracting method of compositions of the natural plant extracts for mouth care.
Background technology
The common illness of tooth is: gingivitis, periodontitis, dental haemorrhage, dental caries, gingival atrophy, halitosis, have dental calculus etc., the number of patients of EPDML investigation display dental caries and gingivitis is the highest, the above people of 85% suffers from gingivitis, so the oral care product developing more effective control gingivitis has prior realistic meaning.But real product and the most of actual effect of patent not remarkable.Now, people are more it is desirable that existing very strong effect has again the product of good mouthfeel simultaneously.And to realize these objects apply which type of effect material and in practice how application just to seem particular importance.
Radix Ginseng Rubra is the one of Chinese medicine, belongs to Umbellales, Araliaceae.Radix Ginseng Rubra is the ripe articles for use of Radix Ginseng, has energy strongly invigorating primordial QI, and multiple arteries and veins takes off admittedly, nourishing qi to stop effect.Have outside the effect of invigorating primordial QI, spleen reinforcing lung, promoting the production of body fluid and inducing sedation of the mind, its property of medicine is warmer, has the advantages that fire is large, strength is sufficient, effect is strong, is more longer than strongly invigorating primordial QI, recuperating depleted YANG and rescuing the patient from collapse, nourishing qi to stop.From health body-building angle, Radix Ginseng Rubra is then insufficiency of vital energy and blood and the tonification good merchantable brand of inclined yang deficiency person, all appearance are often afraid of cold, trick is warm, dizzy asthenia, limbs fatigue, fatiguability, dyspnea with shortness of breath, time the performance such as sense coldness in the stomach, long-term diarrhea, insomnia and dreamful sleep, sexual impotence frequent micturition, Radix Ginseng Rubra all can be selected to nourish.
Existing oral care product many employings Flos Caryophylli extract and Cortex Moutan compositions.Effect of Flos Caryophylli extract: warming middle-JIAO, warming the kidney, sending down the abnormal ascending QI, can stomach invigorating; There is good antibacterial action; Also can anthelmintic.For tooth sterilization, dental caries chamber is cleaned, and pain relieving, has remarkable result.Paeonol energy reducing swelling and alleviating pain, prevents and treats dental caries, covers halitosis, the effects such as cleaning oral cavity.First the paeonol as therapeutic component in Cortex Moutan extracts comparatively complicated.And user is usually along with complication such as gingival hemorrhage and gingivitis, stomatitis, halitosis, gingiva pain, simple Flos Caryophylli extract and Cortex Moutan to above-mentioned symptom unsatisfactory curative effect, a kind of oral care product can tackling above-mentioned symptom of market in urgent need.
Summary of the invention
For the problems referred to above, the present invention aims to provide a kind of Radix Ginseng Rubra and Flos Caryophylli Radix Salviae Miltiorrhizae and combines and tackle the oral care product of symptom and the extracting method of compositions such as gingival hemorrhage and gingivitis, stomatitis, halitosis, gingiva pain.
For realizing this technical purpose, the solution of the present invention is: a kind of oral care product, comprises adjuvant, compositions, and the component of described compositions is: Radix Ginseng Rubra extract powder, Cortex Moutan extract powder, Flos Caryophylli extract oil;
The weight percentage of described compositions is: 4 ~ 10% Radix Ginseng Rubra extract powders, 4 ~ 10% Cortex Moutan extract powders, and 82 ~ 90% Flos Caryophyllis extract oil;
In described care product: the percentage by weight of compositions is 0.5 ~ 10%, the percentage by weight of adjuvant is 90 ~ 99.5%.
As preferably, the dosage form of described chamber care product is toothpaste, and be 1 ~ 10% compositions containing weight percentage in it, all the other compositions are toothpaste adjuvant;
Wherein toothpaste adjuvant weight percentage is: abrasivus 15 ~ 45%, essence 0.5 ~ 1.5%, wetting agent 15 ~ 50%, correctives 0.1 ~ 0.4%, foaming agent 0.8 ~ 2.0%, thickening agent 0.2 ~ 2.0%, buffer agent 0.05 ~ 0.5%, pigment 0.005 ~ 0.05%, deionized water surplus.
As preferably, the dosage form of described chamber care product is collutory, and be 0.5 ~ 2% compositions containing weight percentage in it, all the other compositions are collutory adjuvant;
Wherein collutory adjuvant weight percentage is: ethanol 5 ~ 25%, essence 0.4 ~ 0.8%, wetting agent 0.5 ~ 40%, emulsifying agent 0.1 ~ 3%, sweeting agent 0.1 ~ 0.2%, buffer agent 0.1 ~ 0.2%, food coloring 0.005 ~ 0.05%, deionized water surplus.
As preferably, abrasive is winnofil, dicalcium phosphate dehydrate, silicon dioxide, one or more mixing of aluminium hydroxide, anhydrous Polymeric sodium metaphosphate., resin, 4A zeolite; Wetting agent is one or more mixing of polyhydric alcohol that sorbitol (70%), Polyethylene Glycol, glycerol, erythrol etc. can be used for toothpaste; Foaming agent is the nontoxic surfactant of anion, nonionic or both sexes; Thickening agent is sodium carboxymethyl cellulose, HANSHENGJIAO, modified guar, carrageenan, hydroxyethyl-cellulose, and tragacanth gum, mineral coagulant are as Lithium metasilicate magnesium, one or more mixing of thickening type silicon dioxide;
Correctives, antiseptic, buffer agent, food coloring, one or more mixing of deionized water also can be included in toothpaste adjuvant; The material with effect also can be comprised: one or more mixing in zinc citrate, zinc lactate, potassium nitrate in toothpaste adjuvant.
As preferably, described emulsifying agent is Si Pan or alkyl polyglucoside; Anion surfactant is one or more mixing of block copolymer of sodium lauroyl sarcosine, lauroyl Glycine sodium, oxirane and expoxy propane.
An extracting method for compositions in oral care product, concrete steps are as follows:
The first step, pulverizes Radix Ginseng Rubra, adds distilled water soak according to 1:10 weight ratio, and elimination medicinal residues after heating decocts, obtain Radix Ginseng Rubra initial concentration liquid; In Radix Ginseng Rubra initial concentration liquid, add ethanol, distilling under reduced pressure at the temperature of 60 ~ 80 DEG C also reclaims ethanol, and medicinal liquid is concentrated again, by this secondary concentration liquid under reduced pressure spraying dry obtain powdered extract and be called for short Radix Ginseng Rubra extract powder;
Second step, Cortex Moutan is pulverized, and adds distilled water soak respectively according to 1:10 weight ratio, and elimination medicinal residues after heating decocts, obtain Cortex Moutan initial concentration liquid; In Cortex Moutan initial concentration liquid, add ethanol, reclaim ethanol the temperature distilling under reduced pressure of 60 ~ 80 DEG C, medicinal liquid is concentrated again, by this secondary concentration liquid under reduced pressure spraying dry obtain powdered extract and be called for short Cortex Moutan extract powder;
3rd step, gets 4% ~ 10% Radix Ginseng Rubra extract powder, 4% ~ 10% Cortex Moutan extract powder, and 82% ~ 90% Flos Caryophylli is extracted oil and mixes, and obtains natural compositions.
Beneficial effect of the present invention, the method that the Radix Ginseng Rubra in the oral care product of first the application and Cortex Moutan adopt concentrated distillation to make extract powder is refined, and can improve active constituent content, reducing other impurity by refining, and reduces irritated while improving drug effect; Adopt toothpaste or collutory dosage form can improve the curative effect of compositions, promote the resting period of compositions, be convenient to patient and use; Radix Ginseng Rubra Cortex Moutan Flos Caryophylli extract oil three-in-one formula have very strong control gingivitis, stomatitis, halitosis, gingiva pain ability again can strong gingiva.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further details.
An extracting method for compositions in oral care product, concrete steps are as follows:
The first step, pulverizes Radix Ginseng Rubra, adds distilled water soak according to 1:10 weight ratio, and elimination medicinal residues after heating decocts, obtain Radix Ginseng Rubra initial concentration liquid; In Radix Ginseng Rubra initial concentration liquid, add ethanol, distilling under reduced pressure at the temperature of 60 ~ 80 DEG C also reclaims ethanol, and medicinal liquid is concentrated again, by this secondary concentration liquid under reduced pressure spraying dry obtain powdered extract and be called for short Radix Ginseng Rubra extract powder;
Second step, Cortex Moutan is pulverized, and adds distilled water soak respectively according to 1:10 weight ratio, and elimination medicinal residues after heating decocts, obtain Cortex Moutan initial concentration liquid; In Cortex Moutan initial concentration liquid, add ethanol, reclaim ethanol the temperature distilling under reduced pressure of 60 ~ 80 DEG C, medicinal liquid is concentrated again, by this secondary concentration liquid under reduced pressure spraying dry obtain powdered extract and be called for short Cortex Moutan extract powder;
3rd step, gets 4% ~ 10% Radix Ginseng Rubra extract powder, 4% ~ 10% Cortex Moutan extract powder, and 82% ~ 90% Flos Caryophylli is extracted oil and mixes, and obtains natural compositions.
When preparing the extract powder of Radix Ginseng Rubra and Cortex Moutan, can also adopt as supercritical extraction method, ultrasonic extraction method are extracted.
Specific embodiment of the present invention is toothpaste formulations or collutory dosage form.
1. toothpaste formulations embodiment one (percentage by weight, %)
Toothpaste formulations of the present invention adopts dry method one-step method to make, and its formula is:
| Friction-type silicon dioxide: 8 | Thickening type silicon dioxide (thickening agent): 10 |
| Glycerol (wetting agent): 25 | Carrageenan: 1.0 |
| Lauroyl Glycine sodium (thickening agent): 1.8 | Saccharin sodium (sweeting agent): 0.3 |
| Edible essence: 1.2 | Compositions: 5 |
| Edible fruit green: appropriate | Deionized water: surplus |
Making other techniques that also available rows is conventional in the industry of above-mentioned toothpaste formulations, as the method such as two-step method, Wet One-step makes.
Above-mentioned toothpaste formulations have passed through antibacterial experiment in vitro checking, and the toothpaste formulations in the application is done No. 1, experiment numbers, accurate for medicine market being sold a famous brand name for many years word emulsifiable paste product as a comparison, and No. 2, experiment numbers.But get and commonly in oral cavity cause gingivitis bacterium as killing object, with caseinhydrolysate fluid medium at 35 DEG C of constant-temperature incubations, when different toothpaste thinner ratios, observe and press down Bactericidal ability.The result obtained confirms that this toothpaste is to the common anaerobe porphyromonas gingivalis in oral cavity, but accompanying the antibacterials such as unwrapping wire actinomycetes to have well kills effect.
2. toothpaste formulations embodiment two (percentage by weight, %)
Toothpaste formulations of the present invention adopts dry method one-step method to make, and its formula is:
| Natural whiting (400 order): 45% | Thickening type silicon dioxide (thickening agent): 5% |
| Glycerol (wetting agent): 15 | Sorbitol (70%, wetting agent): 30 |
| Sodium carboxymethyl cellulose (thickening agent): 0.5 | Xanthan gum: 0.6 |
| Sodium lauryl sulphate (foaming agent): 1.8 | Saccharin sodium (sweeting agent): 1.2 |
| Edible essence: 1.2 | Compositions: 1 |
| Edible light green pigment: appropriate | Deionized water: surplus |
Upper embodiment processing technology is identical with first case, the same effect with reasonable control gingivitis, halitosis, ulcer after it being compared 45 days with blank product when clinical verification.
3. toothpaste formulations embodiment three (percentage by weight, %)
Toothpaste formulations of the present invention adopts dry method one-step method to make, and its formula is:
| Dicalcium phosphate dehydrate (400 order): 44 | Thickening type silicon dioxide (thickening agent): 5 |
| Sorbitol (70%, wetting agent): 15 | Locust bean gum (thickening agent): 0.5 |
| Guar gum: 0.5 | Sodium lauroyl sarcosine (foaming agent): 1.8 |
| Saccharin sodium (sweeting agent): 0.2 | Edible essence: 1.2 |
| Compositions: 10 | Edible light blue pigment: appropriate |
| Deionized water: surplus |
Upper embodiment processing technology is identical with first case, the same effect with reasonable control gingivitis, halitosis, ulcer after it being compared 45 days with blank product when clinical verification.
4. collutory Formulation Example one: (percentage by weight, %)
Collutory of the present invention, its formula (weight percentage, gross weight 100 parts) is:
Production method can be conventional method: after emulsifying agent and the mixing of materials such as ethanol, flavouring agent stirring and dissolving, slowly add deionized water, sorbitol etc., stir till solution is transparent, leave standstill, namely can packed products after about 5 DEG C coolings are filtered for 24 hours.
5. collutory Formulation Example two: (percentage by weight, %)
| Ethanol: 10 | Sorbitol: 15 |
| Twen-20 (emulsifying agent): 2.5 | Edible essence (flavouring agent): 0.6 |
| Edible glucide (sweeting agent): 0.2 | Compositions: 0.5 |
| Sodium dihydrogen phosphate: 0.1 | Dibastic sodium phosphate: 0.1 |
| Edible bright blue pigment: appropriate | Deionized water: surplus |
Upper embodiment manufacture method is identical with collutory Formulation Example one.
6. collutory Formulation Example three: (percentage by weight, %)
| Ethanol: 18 | Sorbitol: 15 |
| CO-40 (emulsifying agent): 2 | Edible essence (flavouring agent): 0.6 |
| Compositions: 5 | Sodium dihydrogen phosphate: 0.1 |
| Dibastic sodium phosphate: 0.1 | Edible bright blue pigment: appropriate |
| Deionized water: surplus |
Upper embodiment manufacture method is identical with collutory Formulation Example one.
The clinical case experiment of toothpaste formulations of the present invention is as follows:
1. scheme: Double-blind randomized clinical trial design, experimenter be age 20-23 year, experimenter is divided into matched group and test group at random.At baseline, use after toothpaste and check and record full mouth all tooth gingivitiss index of correlation respectively in 4 weeks and 12 weeks, every tooth check 4 sites (cheek side near in, central authorities, far away in 3 sites and tongue side central).
2. toothpaste: provided by Canton Baicaotang Pharmaceutical Co., Ltd is unguentum, and outward appearance mark is consistent, is marked with A, D printed words respectively; Wherein the formula of A is the toothpaste formulations of toothpaste formulations embodiment one, D is specific embodiment two.
3. toothbrush: the soft wire type toothbrush of good enlightening exquisite (Chaonan District, Shantou City Tai Mei Industrial Co., Ltd.).
4. concrete using method
4.1 dosage: experimental group, matched group experimenter brush teeth 2 times sooner or later every day, each use 2 grams, toothpaste.
4.2 courses for the treatment of: 12 weeks.
4.3 gingival index (GI):
0: NIP;
1: mild inflammation, gingiva color and luster and quality slightly change;
2: moderate inflammation, gingiva light, red, swollen, hypertrophy;
3: hyperphlogosis, gingiva obviously rubescent, hypertrophy, have hematostaxis.
The gingival index of two groups of experimenters, BOP% Indexes Comparison, when meeting (contrast-test)/contrast >=12%, product has and alleviates gingivitis, improves gingival hemorrhage effect.
1, result
4.4 experimenters: have 65 experimenters and complete omnidistance observation, wherein A group 30 people, D group 35 people; Male 38 people, women 27 people.
5. liang group experimenter uses the situation of change of periodontal index before and after toothpaste
The baseline value of two groups of experimenters GI, BOP% before using toothpaste is respectively through statistical test, and difference that there are no significant (P > 0.05), has comparability.
5.1 liang of group experimenters use the comparison of GI before and after toothpaste
Before using A toothpaste, the baseline value of the equal GI of A group experimenter tooth is 2.15, and use A toothpaste after 4 weeks, the equal GI of tooth drops to 2.10, have dropped 2.38%; Use A toothpaste after 12 weeks, the equal GI of tooth drops to 1.88, have dropped 12.7%.Before using D toothpaste, the baseline value of the equal GI of D group experimenter tooth is 2.24, and use D toothpaste after 4 weeks, the equal GI of tooth drops to 1.89, have dropped 15.7%; Use D toothpaste after 12 weeks, the equal GI of tooth drops to 1.73, have dropped 22.7%.
5.2 liang of group experimenters use the comparison of BOP% before and after toothpaste
Before using A toothpaste, the baseline value of A group experimenter BOP% is 7.74%, and use A toothpaste after 4 weeks, BOP% drops to 5.83%, have dropped 24.6%; Use A toothpaste after 12 weeks, BOP% rises to 9.04%, rises 16.9%.Before using D toothpaste, the baseline value of D group experimenter BOP% is 7.04%, and use D toothpaste after 4 weeks, BOP% drops to 5.30%, have dropped 24.6%; Use D toothpaste after 12 weeks, BOP% drops to 6.33%, have dropped 10.1%.
All have no adverse reaction after two groups of experimenters use toothpaste respectively, good mouthfeel.
6. conclusion
Tested by double blind random, use A, D two kinds of toothpaste all to have no adverse reaction.Use D toothpaste group comparatively to use the equal GI of tooth of A toothpaste group experimenter and gingivitis and hemorrhage index to improve significantly, point out D toothpaste to have and significantly improve gingivitis and alleviate hemorrhage effect.
The above; be only preferred embodiment of the present invention; not in order to limit the present invention, every above embodiment is done according to technical spirit of the present invention any trickle amendment, equivalently replace and improve, within the protection domain that all should be included in technical solution of the present invention.
Claims (6)
1. an oral care product, comprises adjuvant, compositions, it is characterized in that: the component of described compositions is: Radix Ginseng Rubra extract powder, Cortex Moutan extract powder, Flos Caryophylli extract oil;
The weight percentage of described compositions is: 4 ~ 10% Radix Ginseng Rubra extract powders, 4 ~ 10% Cortex Moutan extract powders, and 82 ~ 90% Flos Caryophyllis extract oil;
In described care product: the percentage by weight of compositions is 0.5 ~ 10%, the percentage by weight of adjuvant is 90 ~ 99.5%.
2. oral care product according to claim 1, is characterized in that: the dosage form of described oral care product is toothpaste, and containing weight percentage in it is 1 ~ 10% compositions, and all the other compositions are toothpaste adjuvant;
Wherein toothpaste adjuvant weight percentage is: abrasivus 15 ~ 45%, essence 0.5 ~ 1.5%, wetting agent 15 ~ 50%, correctives 0.1 ~ 0.4%, foaming agent 0.8 ~ 2.0%, thickening agent 0.2 ~ 2.0%, buffer agent 0.05 ~ 0.5%, pigment 0.005 ~ 0.05%, deionized water surplus.
3. oral care product according to claim 1, is characterized in that: the dosage form of described oral care product is collutory, and containing weight percentage in it is 0.5 ~ 2% compositions, and all the other compositions are collutory adjuvant;
Wherein collutory adjuvant weight percentage is: ethanol 5 ~ 25%, essence 0.4 ~ 0.8%, wetting agent 0.5 ~ 40%, emulsifying agent 0.1 ~ 3%, sweeting agent 0.1 ~ 0.2%, buffer agent 0.1 ~ 0.2%, food coloring 0.005 ~ 0.05%, deionized water surplus.
4. oral care product according to claim 2, is characterized in that: abrasive is winnofil, dicalcium phosphate dehydrate, silicon dioxide, one or more mixing of aluminium hydroxide, anhydrous Polymeric sodium metaphosphate., resin, 4A zeolite; Wetting agent is one or more mixing of polyhydric alcohol that sorbitol (70%), Polyethylene Glycol, glycerol, erythrol etc. can be used for toothpaste; Foaming agent is the nontoxic surfactant of anion, nonionic or both sexes; Thickening agent is sodium carboxymethyl cellulose, HANSHENGJIAO, modified guar, carrageenan, hydroxyethyl-cellulose, and tragacanth gum, mineral coagulant are as Lithium metasilicate magnesium, one or more mixing of thickening type silicon dioxide;
Correctives, antiseptic, buffer agent, food coloring, one or more mixing of deionized water also can be included in toothpaste adjuvant; The material with effect also can be comprised: one or more mixing in zinc citrate, zinc lactate, potassium nitrate in toothpaste adjuvant.
5. oral care product according to claim 3, is characterized in that: described emulsifying agent is Si Pan or alkyl polyglucoside; Anion surfactant is one or more mixing of block copolymer of sodium lauroyl sarcosine, lauroyl Glycine sodium, oxirane and expoxy propane.
6. the extracting method of compositions in oral care product according to claim 1, is characterized in that: concrete steps are as follows:
The first step, pulverizes Radix Ginseng Rubra, adds distilled water soak according to 1:10 weight ratio, and elimination medicinal residues after heating decocts, obtain Radix Ginseng Rubra initial concentration liquid; In Radix Ginseng Rubra initial concentration liquid, add ethanol, distilling under reduced pressure at the temperature of 60 ~ 80 DEG C also reclaims ethanol, and medicinal liquid is concentrated again, by this secondary concentration liquid under reduced pressure spraying dry obtain powdered extract and be called for short Radix Ginseng Rubra extract powder;
Second step, Cortex Moutan is pulverized, and adds distilled water soak respectively according to 1:10 weight ratio, and elimination medicinal residues after heating decocts, obtain Cortex Moutan initial concentration liquid; In Cortex Moutan initial concentration liquid, add ethanol, reclaim ethanol the temperature distilling under reduced pressure of 60 ~ 80 DEG C, medicinal liquid is concentrated again, by this secondary concentration liquid under reduced pressure spraying dry obtain powdered extract and be called for short Cortex Moutan extract powder;
3rd step, gets 4% ~ 10% Radix Ginseng Rubra extract powder, 4% ~ 10% Cortex Moutan extract powder, and 82% ~ 90% Flos Caryophylli is extracted oil and mixes, and obtains natural compositions.
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Application publication date: 20150128 |