CN106236612A - A kind of toothpaste and preparation method thereof - Google Patents
A kind of toothpaste and preparation method thereof Download PDFInfo
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- CN106236612A CN106236612A CN201610739882.2A CN201610739882A CN106236612A CN 106236612 A CN106236612 A CN 106236612A CN 201610739882 A CN201610739882 A CN 201610739882A CN 106236612 A CN106236612 A CN 106236612A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses a kind of toothpaste, including plant basis quintessence oil and toothpaste matrix, described plant basis quintessence oil includes the component of following weight portion: Borneolum Syntheticum 0.1～3 parts, Oleum Anisi Stellati 1～15 parts, Oleum Eucalypti 1～20 parts, methyl salicylate 10～80 parts, Oleum Ocimi Gratissimi 1～10 parts, Oleum menthae 10～80 parts, Mentholum 1～15 parts.Toothpaste abnormal smells from the patient of the present invention is refrigerant, have inhibiting bacteria and diminishing inflammation, have one's ideas straightened out refresh oneself, reducing swelling and alleviating pain, refrigerant effect such as antipruritic, can be as the daily assistant product of the oral diseases such as treatment gingival swelling and pain, gingival hemorrhage, periodontitis, halitosis, formula is simple.Meanwhile, the invention also discloses the preparation method of described toothpaste.
Description
Technical field
The invention belongs to articles for daily use field, especially a kind of toothpaste and preparation method thereof.
Background technology
Toothpaste is a kind of dental care product that people's daily life be unable to do without, along with the raising of people's living standard, raw
Some misconducts in the change of custom of living and life, people are more and more higher to the requirement of toothpaste, except cleaning oral cavity, remove
The thin film of dental surface and bacterial plaque, do not damage enamel and dentin, has outside the key propertys such as comfortable fragrance and taste, also
Require that toothpaste can assist the oral cavity disease that treatment gingival swelling and pain, gingival hemorrhage, periodontitis, halitosis etc. are brought because of bad life-form structure
Sick.Although at present the kind of toothpaste is with kind a lot, and constantly has kind to occur, but toothpaste is as a kind of traditional daily
Product, the most still occupy important using value and the market share.
Summary of the invention
Based on this, in place of it is an object of the invention to overcome above-mentioned the deficiencies in the prior art, provide a kind of containing plant base
Plinth quintessence oil, fragrant odour and having clear away heart-fire refresh oneself, inhibiting bacteria and diminishing inflammation and pain relieving, the toothpaste of the various oral disease for the treatment of and preparation thereof
Method.
For achieving the above object, the technical solution used in the present invention is: a kind of toothpaste, including plant basis quintessence oil and tooth
Cream base matter, described plant basis quintessence oil includes the component of following weight portion: Borneolum Syntheticum 0.1～3 parts, Oleum Anisi Stellati 1～15 parts, eucalyptus globulus
Oil 1～20 part, methyl salicylate 10～80 parts, Oleum Ocimi Gratissimi 1～10 parts, Oleum menthae 10～80 parts, Mentholum 1～15 parts.
Preferably, described plant basis quintessence oil includes the component of following weight portion: Borneolum Syntheticum 0.1～1 part, Oleum Anisi Stellati 1
～5 parts, Oleum Eucalypti 1～10 parts, methyl salicylate 20～50 parts, Oleum Ocimi Gratissimi 1～5 parts, Oleum menthae 20～50 parts, Mentholum 1
～5 parts.
It is highly preferred that described plant basis quintessence oil includes the component of following weight portion: Borneolum Syntheticum 0.42 part, Oleum Anisi Stellati
3.35 parts, Oleum Eucalypti 6.69 parts, methyl salicylate 41.84 parts, Oleum Ocimi Gratissimi 2.51 parts, Oleum menthae 41.84 parts, Mentholum 3.35
Part.
Toothpaste of the present invention adds plant basis quintessence oil, makes toothpaste while having health care, cleaning function, also have
Have auxiliary therapeutic action, not only increase fragrant odour, and have clear away heart-fire refresh oneself, inhibiting bacteria and diminishing inflammation and pain relieving, treatment oral cavity disease
The effects such as disease, are a kind of cleaning, the articles for daily use for the treatment of dual function, have widened the use value of toothpaste.
Wherein, in the quintessence oil of plant basis, Oleum Eucalypti has the effect that wind-expelling pain-stopping, antiinflammatory are antibacterial；Oleum Anisi Stellati be from
The aromatic oil that anistree branch, leaf, really steaming and decocting extract, is commonly called as Oleum Anisi Stellati or Fructus Anisi Stellati oil, has Fructus Foeniculi, Radix Glycyrrhizae, isoesdragol fragrance,
It has certain antibacterial action；The quintessence oil that Oleum menthae is the fresh stem by plant Herba Menthae and Ye Jing vapor distillation obtains, has spy
Different refrigerant fragrance, has refrigerant antipruritic, anti-inflammatory analgetic, alleviates the effects such as edema, sterilization, refreshment；Borneolum Syntheticum can have one's ideas straightened out refreshment,
Clearing away heat to alleviate pain, anti-inflammation and sterilization, have original prevention and treatment to make to oral diseases such as ulcerative stomatitis, throat ability to speak swell and ache
With；Mentholum can be with refrigerant antipruritic, anti-inflammatory and antalgic, antibacterial, antiviral, it is possible to be used for treating toothache, oral mucositis；Flos Caryophylli sieve
Strangle oil and there is antiinflammatory antisepsis, the treatment of dental caries can be used for；Methyl salicylate can antifungal, antiinflammatory, subside a swelling, ease pain only
Itching, refresh oneself, clinic is also used for treatment toothache.The plants essential oil toothpaste made at selected weight portion with above-mentioned 7 kinds of plants essential oils, this
Applicant has been surprisingly found that this toothpaste has that fragrant odour is refrigerant, refreshes oneself, antiinflammatory is antibacterial and the effect of pain relieving, and can assist treatment tooth
The various oral diseases such as gum swells and ache, gingival hemorrhage, periodontitis, halitosis, dental caries, alleviate the uncomfortable symptom in various oral cavity.
Preferably, described toothpaste matrix comprises the component of following weight portion: abrasivus 40～50 parts, adhesive 2～5 parts,
Wetting agent 20～25 parts, foaming agent 2～5 parts, resist 0～0.8 part, excipient 0.5～1 part, solvent 15～25 parts, titanium dioxide
Titanium 0.5～1 part, zinc chloride 0.03～0.1 part, saccharin 0.3～0.5 part, glycine 0.03～0.1 part.
It is highly preferred that described toothpaste matrix comprises the component of following weight portion: abrasivus 45 parts, adhesive 3 parts, wetting agent
25 parts, foaming agent 3 parts, resist 0.3 part, excipient 0.6 part, solvent 22 parts, titanium dioxide 0.5 part, zinc chloride 0.1 part, sugar
Essence 0.4 part, glycine 0.1 part.
It is highly preferred that described abrasivus is silicon dioxide；Described adhesive is starch；Described wetting agent is glycerol；Described
Foaming agent is sodium lauryl sulphate；Described resist is waterglass；Described excipient is Magnesium dichloride hexahydrate；Described solvent is
Deionized water.
The effect of described abrasivus is to increase the friction of toothpaste and tooth, serves to clean the teeth；Described foaming agent
Effect be foaming, increase mouthfeel, have certain cleaning action concurrently；The effect of described resist is to ensure that stablizing of aluminum pipe；Institute
State excipient and act primarily as colloid coagulation, to reach figuration purpose；Described titanium dioxide is opacifier, and saccharin is as sweet taste
Agent, zinc chloride is made astringent, desensitizer, is coordinated with glycine, reduces oral cavity sense of discomfort.
Preferably, quintessence oil percentage by weight in described toothpaste in described plant basis is 0.1%～5%, described toothpaste
Substrate percentage by weight in described toothpaste is 95%～99.9%.
Meanwhile, the present invention also provides for the preparation method of a kind of described toothpaste, it is characterised in that described preparation method is:
(1) by the adhesive in toothpaste matrix composition, wetting agent and saccharin uniform dissolution in a solvent；
(2) in the solution that step (1) obtains, add other compositions in toothpaste matrix, uniformly mix；
(3) grinding, heat de-airing are to suitable viscosity；
(4) call in the plant basis quintessence oil of mix homogeneously, fill, packaging, obtain described toothpaste.
Preferably, the preparation method of described toothpaste is:
(1) load weighted starch first adds the deionized water of 80%, and agitating heating 10min (in heating process, be noted
The meaning distillation water yield should keep constant), add glycerol stirring, then saccharin is dissolved in remaining 20% deionized water, system
Become liquor saccharini to add to stir evenly；
(2) remaining liq composition contained in toothpaste matrix is poured in homogenizer, the most first put into toothpaste matrix
Half powder contained by, is stirring evenly and then adding into foaming agent and (first foaming agent is dissolved in certain water, under agitation adds
Enter) and second half powder remaining, stir 10min, till uniformly；
(3) grind with the colloid mill of 5 μm；
(4) heat de-airing is to suitable viscosity；
(5) call in the plant basis quintessence oil of mix homogeneously, get final product fill, packaging, obtain described toothpaste.
Relative to prior art, the invention have the benefit that toothpaste of the present invention contains plant basis quintessence oil, abnormal smells from the patient
Refrigerant, halitosis can be removed, make oral cavity the most pure and fresh, have inhibiting bacteria and diminishing inflammation, have one's ideas straightened out refresh oneself, reducing swelling and alleviating pain, refrigerant effect such as antipruritic,
Can as treatment gingival swelling and pain, gingival hemorrhage, periodontitis, the daily assistant product of halitosis, alleviate the number of times of drug administration with
And the various malaise symptoms that drug administration causes；Can meet people to toothpaste abnormal smells from the patient, the demand of performance, formula is simple, raw simultaneously
Produce easily, be with a wide range of applications.
Detailed description of the invention
For better illustrating the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Embodiment 1
A kind of embodiment of toothpaste of the present invention, toothpaste described in the present embodiment includes the composition of following percentage by weight:
Plant basis quintessence oil 0.1%, toothpaste matrix 99.9%；
Described plant basis quintessence oil includes the component of following weight portion: Borneolum Syntheticum 0.42 part, Oleum Anisi Stellati 3.35 parts, Oleum Eucalypti
6.69 parts, methyl salicylate 41.84 parts, Oleum Ocimi Gratissimi 2.51 parts, Oleum menthae 41.84 parts, Mentholum 3.35 parts；
Described toothpaste matrix includes the component of following weight portion: silicon dioxide 45 parts, starch 3 parts, glycerol 25 parts, dodecane
3 parts of base sodium sulfate, waterglass 0.3 part, Magnesium dichloride hexahydrate 0.6 part, deionized water 22 parts, titanium dioxide 0.5 part, zinc chloride
0.1 part, 0.4 part of saccharin, glycine 0.1 part.The preparation method of toothpaste described in the present embodiment is:
(1) by the starch in toothpaste matrix composition, glycerol and saccharin, dissolve in deionized water, stir；
(2) in the solution that step (1) obtains, add other compositions in toothpaste matrix, stir 10min, until uniformly
Till mixing；
(3) grind with the colloid mill of 5 μm；
(4) heat de-airing is to suitable viscosity；
(5) call in the plant basis quintessence oil of mix homogeneously, get final product fill, packaging, obtain described toothpaste.
Embodiment 2
A kind of embodiment of toothpaste of the present invention, toothpaste described in the present embodiment includes the composition of following percentage by weight:
Plant basis quintessence oil 0.5%, toothpaste matrix 99.5%；
Described plant basis quintessence oil includes the component of following weight portion: Borneolum Syntheticum 0.42 part, Oleum Anisi Stellati 3.35 parts, Oleum Eucalypti
6.69 parts, methyl salicylate 41.84 parts, Oleum Ocimi Gratissimi 2.51 parts, Oleum menthae 41.84 parts, Mentholum 3.35 parts.
Described toothpaste matrix includes the component of following weight portion: silicon dioxide 40 parts, starch 2 parts, glycerol 20 parts, dodecane
2 parts of base sodium sulfate, waterglass 0.3 part, Magnesium dichloride hexahydrate 0.5 part, deionized water 15 parts, titanium dioxide 0.5 part, zinc chloride
0.03 part, 0.3 part of saccharin, glycine 0.06 part.
The preparation method of toothpaste described in the present embodiment is:
(1) by the starch in toothpaste matrix composition, glycerol and saccharin, dissolve in deionized water, stir；
(2) in the solution that step (1) obtains, add other compositions in toothpaste matrix, stir 10min, until uniformly
Till mixing；
(3) grind with the colloid mill of 5 μm；
(4) heat de-airing is to suitable viscosity；
(5) call in the plant basis quintessence oil of mix homogeneously, get final product fill, packaging, obtain described toothpaste.
Embodiment 3
A kind of embodiment of toothpaste of the present invention, toothpaste described in the present embodiment includes the composition of following percentage by weight:
Plant basis quintessence oil 1%, toothpaste matrix 99%；
Described plant basis quintessence oil includes the component of following weight portion: Borneolum Syntheticum 0.42 part, Oleum Anisi Stellati 3.35 parts, Oleum Eucalypti
6.69 parts, methyl salicylate 41.84 parts, Oleum Ocimi Gratissimi 2.51 parts, Oleum menthae 41.84 parts, Mentholum 3.35 parts.
Described toothpaste matrix includes the component of following weight portion: silicon dioxide 50 parts, starch 5 parts, glycerol 25 parts, dodecane
5 parts of base sodium sulfate, waterglass 0.8 part, Magnesium dichloride hexahydrate 1 part, deionized water 25 parts, titanium dioxide 1 part, zinc chloride 0.05
Part, 0.5 part of saccharin, glycine 0.03 part.
The preparation method of toothpaste described in the present embodiment is:
(1) by the starch in toothpaste matrix composition, glycerol and saccharin, dissolve in deionized water, stir；
(2) in the solution that step (1) obtains, add other compositions in toothpaste matrix, stir 10min, until uniformly
Till mixing；
(3) grind with the colloid mill of 5 μm；
(4) heat de-airing is to suitable viscosity；
(5) call in the plant basis quintessence oil of mix homogeneously, get final product fill, packaging, obtain described toothpaste.
Embodiment 4
A kind of embodiment of toothpaste of the present invention, toothpaste described in the present embodiment includes the composition of following percentage by weight:
Plant basis quintessence oil 2%, toothpaste matrix 98%；
Described plant basis quintessence oil includes the component of following weight portion: Borneolum Syntheticum 0.42 part, Oleum Anisi Stellati 3.35 parts, Oleum Eucalypti
6.69 parts, methyl salicylate 41.84 parts, Oleum Ocimi Gratissimi 2.51 parts, Oleum menthae 41.84 parts, Mentholum 3.35 parts.
Described toothpaste matrix includes the component of following weight portion: silicon dioxide 42 parts, starch 4 parts, glycerol 21 parts, dodecane
4 parts of base sodium sulfate, waterglass 0.1 part, Magnesium dichloride hexahydrate 0.7 part, deionized water 20 parts, titanium dioxide 0.6 part, zinc chloride
0.04 part, 0.35 part of saccharin, glycine 0.04 part.
The preparation method of toothpaste described in the present embodiment is:
(1) by the starch in toothpaste matrix composition, glycerol and saccharin, dissolve in deionized water, stir；
(2) in the solution that step (1) obtains, add other compositions in toothpaste matrix, stir 10min, until uniformly
Till mixing；
(3) grind with the colloid mill of 5 μm；
(4) heat de-airing is to suitable viscosity；
(5) call in the plant basis quintessence oil of mix homogeneously, get final product fill, packaging, obtain described toothpaste.
Embodiment 5
A kind of embodiment of toothpaste of the present invention, toothpaste described in the present embodiment includes the composition of following percentage by weight:
Plant basis quintessence oil 3%, toothpaste matrix 97%；
Described plant basis quintessence oil includes the component of following weight portion: Borneolum Syntheticum 0.42 part, Oleum Anisi Stellati 3.35 parts, Oleum Eucalypti
6.69 parts, methyl salicylate 41.84 parts, Oleum Ocimi Gratissimi 2.51 parts, Oleum menthae 41.84 parts, Mentholum 3.35 parts.
Described toothpaste matrix includes the component of following weight portion: silicon dioxide 48 parts, starch 2.5 parts, glycerol 22 parts, 12
Alkyl sodium sulfate 2.5 parts, waterglass 0.2 part, Magnesium dichloride hexahydrate 0.8 part, deionized water 18 parts, titanium dioxide 0.7 part, chlorination
0.06 part of zinc, 0.45 part of saccharin, glycine 0.05 part.
The preparation method of toothpaste described in the present embodiment is:
(1) by the starch in toothpaste matrix composition, glycerol and saccharin, dissolve in deionized water, stir；
(2) in the solution that step (1) obtains, add other compositions in toothpaste matrix, stir 10min, until uniformly
Till mixing；
(3) grind with the colloid mill of 5 μm；
(4) heat de-airing is to suitable viscosity；
(5) call in the plant basis quintessence oil of mix homogeneously, get final product fill, packaging, obtain described toothpaste.
Embodiment 6
A kind of embodiment of toothpaste of the present invention, toothpaste described in the present embodiment includes the composition of following percentage by weight:
Plant basis quintessence oil 5%, toothpaste matrix 95%；
Described plant basis quintessence oil includes the component of following weight portion: Borneolum Syntheticum 0.42 part, Oleum Anisi Stellati 3.35 parts, Oleum Eucalypti
6.69 parts, methyl salicylate 41.84 parts, Oleum Ocimi Gratissimi 2.51 parts, Oleum menthae 41.84 parts, Mentholum 3.35 parts.
Described toothpaste matrix includes the component of following weight portion: silicon dioxide 41 parts, starch 3.5 parts, glycerol 23 parts, 12
Alkyl sodium sulfate 3.5 parts, waterglass 0.4 part, Magnesium dichloride hexahydrate 0.9 part, deionized water 24 parts, titanium dioxide 0.8 part, chlorination
0.07 part of zinc, 0.3 part of saccharin, glycine 0.06 part.
The preparation method of toothpaste described in the present embodiment is:
(1) by the starch in toothpaste matrix composition, glycerol and saccharin, dissolve in deionized water, stir；
(2) in the solution that step (1) obtains, add other compositions in toothpaste matrix, stir 10min, until uniformly
Till mixing；
(3) grind with the colloid mill of 5 μm；
(4) heat de-airing is to suitable viscosity；
(5) call in the plant basis quintessence oil of mix homogeneously, get final product fill, packaging, obtain described toothpaste.
Embodiment 7
A kind of embodiment of toothpaste of the present invention, toothpaste described in the present embodiment includes the composition of following percentage by weight:
Plant basis quintessence oil 1.5%, toothpaste matrix 98.5%；
Described plant basis quintessence oil includes the component of following weight portion: Borneolum Syntheticum 0.1 part, Oleum Anisi Stellati 1 part, Oleum Eucalypti 1 part,
Methyl salicylate 10 parts, Oleum Ocimi Gratissimi 1 part, Oleum menthae 10 parts, Mentholum 1 part；
Described toothpaste matrix includes the component of following weight portion: silicon dioxide 43 parts, starch 4.5 parts, glycerol 24 parts, 12
Alkyl sodium sulfate 4.5 parts, waterglass 0.5 part, Magnesium dichloride hexahydrate 0.6 part, deionized water 16 parts, titanium dioxide 0.9 part, chlorination
0.08 part of zinc, 0.4 part of saccharin, glycine 0.07 part.
The preparation method of toothpaste described in the present embodiment is:
(1) by the starch in toothpaste matrix composition, glycerol and saccharin, dissolve in deionized water, stir；
(2) in the solution that step (1) obtains, add other compositions in toothpaste matrix, stir 10min, until uniformly
Till mixing；
(3) grind with the colloid mill of 5 μm；
(4) heat de-airing is to suitable viscosity；
(5) call in the plant basis quintessence oil of mix homogeneously, get final product fill, packaging, obtain described toothpaste.
Embodiment 8
A kind of embodiment of toothpaste of the present invention, toothpaste described in the present embodiment includes the composition of following percentage by weight:
Plant basis quintessence oil 2.5%, toothpaste matrix 97.5%；
Described plant basis quintessence oil includes the component of following weight portion: Borneolum Syntheticum 1 part, Oleum Anisi Stellati 5 parts, Oleum Eucalypti 10 parts,
Methyl salicylate 20 parts, Oleum Ocimi Gratissimi 5 parts, Oleum menthae 20 parts, Mentholum 5 parts.
Described toothpaste matrix includes the component of following weight portion: silicon dioxide 44 parts, starch 2.8 parts, glycerol 21.5 parts, ten
Sodium dialkyl sulfate 3 parts, waterglass 0.3 part, Magnesium dichloride hexahydrate 0.6 part, deionized water 17 parts, titanium dioxide 0.5 part, chlorination
0.1 part of zinc, 0.4 part of saccharin, glycine 0.08 part.
The preparation method of toothpaste described in the present embodiment is:
(1) by the starch in toothpaste matrix composition, glycerol and saccharin, dissolve in deionized water, stir；
(2) in the solution that step (1) obtains, add other compositions in toothpaste matrix, stir 10min, until uniformly
Till mixing；
(3) grind with the colloid mill of 5 μm；
(4) heat de-airing is to suitable viscosity；
(5) call in the plant basis quintessence oil of mix homogeneously, get final product fill, packaging, obtain described toothpaste.
Embodiment 9
A kind of embodiment of toothpaste of the present invention, toothpaste described in the present embodiment includes the composition of following percentage by weight:
Plant basis quintessence oil 4%, toothpaste matrix 96%；
Described plant basis quintessence oil includes the component of following weight portion: Borneolum Syntheticum 3 parts, Oleum Anisi Stellati 15 parts, Oleum Eucalypti 20 parts,
Methyl salicylate 50 parts, Oleum Ocimi Gratissimi 10 parts, Oleum menthae 80 parts, Mentholum 15 parts.
Described toothpaste matrix includes the component of following weight portion: silicon dioxide 46 parts, starch 3.2 parts, glycerol 22.5 parts, ten
Sodium dialkyl sulfate 3 parts, waterglass 0.7 part, Magnesium dichloride hexahydrate 0.6 part, deionized water 23 parts, titanium dioxide 0.5 part, chlorination
0.1 part of zinc, 0.4 part of saccharin, glycine 0.1 part.
The preparation method of toothpaste described in the present embodiment is:
(1) by the starch in toothpaste matrix composition, glycerol and saccharin, dissolve in deionized water, stir；
(2) in the solution that step (1) obtains, add other compositions in toothpaste matrix, stir 10min, until uniformly
Till mixing；
(3) grind with the colloid mill of 5 μm；
(4) heat de-airing is to suitable viscosity；
(5) call in the plant basis quintessence oil of mix homogeneously, get final product fill, packaging, obtain described toothpaste.
Embodiment 10
A kind of embodiment of toothpaste of the present invention, toothpaste described in the present embodiment includes the composition of following percentage by weight:
Plant basis quintessence oil 4.5%, toothpaste matrix 95.5%；
Described plant basis quintessence oil includes the component of following weight portion: Borneolum Syntheticum 0.5 part, Oleum Anisi Stellati 10 parts, Oleum Eucalypti 15
Part, methyl salicylate 80 parts, Oleum Ocimi Gratissimi 3 parts, Peppermint Oil 50 part, Mentholum 9 parts.
Described toothpaste matrix includes the component of following weight portion: silicon dioxide 47 parts, starch 2.9 parts, glycerol 23.5 parts, ten
Sodium dialkyl sulfate 3 parts, waterglass 0.3 part, Magnesium dichloride hexahydrate 0.6 part, deionized water 21 parts, titanium dioxide 0.5 part, chlorination
0.1 part of zinc, 0.4 part of saccharin, glycine 0.1 part.
The preparation method of toothpaste described in the present embodiment is:
(1) by the starch in toothpaste matrix composition, glycerol and saccharin, dissolve in deionized water, stir；
(2) in the solution that step (1) obtains, add other compositions in toothpaste matrix, stir 10min, until uniformly
Till mixing；
(3) grind with the colloid mill of 5 μm；
(4) heat de-airing is to suitable viscosity；
(5) call in the plant basis quintessence oil of mix homogeneously, get final product fill, packaging, obtain described toothpaste.
Embodiment 11
The present embodiment toothpaste preparation-obtained to present invention curative effect situation research experiment to periodontitis.
(1) object of observation
Select chronic periodontitis patient 136 example, male 56 examples, female 80 example.Age 20～65 years old, average 34.8 years old.Use double blinding
Method is randomly divided into treatment group (74 example) and matched group (62 example).The state of an illness of two groups of patients, sex, age aspect are through statistical procedures
No significant difference (P > 0.05), has comparability.
(2) test specimen
Test group: use the toothpaste prepared by the present invention.
Matched group: homemade toothpaste.Preparing according to the preparation technology of the present invention, wherein, plant basis quintessence oil is containing only Herba Menthae
Oil, without Oleum Eucalypti, Borneolum Syntheticum, Oleum Ocimi Gratissimi, Oleum Anisi Stellati, methyl salicylate, 6 kinds of quintessence oils of Mentholum.
(3) Therapeutic Method
Test group uses toothpaste prepared by the present invention, and matched group uses homemade toothpaste.Morning every day, evening brush teeth each 1 time, often
Secondary lasting 5～10min, 10d is a course for the treatment of, disables other medicines during treatment.
(4) observation index and standard
1. clinical symptoms and the change of sign.Recovery from illness: 10d after medication, gingival hemorrhage, halitosis, toothache transference cure, chews
Functional rehabilitation.Effective: gingival hemorrhage, halitosis disappear, periodontal pocket shoals, masticatory function is improved.Take a turn for the better: gingival hemorrhage, halitosis subtract
Gently, odontoseisis improves.Invalid: clinical symptoms and sign are without changing.2. index of gingivitis (GI) refers to each gingivitis number of degrees sum
Divided by total tooth number.Indexing standard is: 0 ° is normal gingiva；I ° refers to gingiva mild inflammation, and scope is confined to gum edge, and spy is examined the most hemorrhage；
II ° refers to moderate inflammation, and inflammation relatively disperse also involves attached gingiva, visits tactile hemorrhage；III ° refers to hyperphlogosis, and gingiva is substantially red and swollen or bursts
Rotten, inflammation disperse to attached gingiva, hematostaxis.3. antibacterial change in periodontal pocket: all cases are all forward and backward in treatment, respectively
Take periodontal pocket endocrine and do Gram staining bacteria inspection.
(5) result of the test
1. clinical efficacy: treatment group total effective rate (recovery from illness adds effective and takes a turn for the better) is 93.24%, and matched group is 37.10%,
Two groups of efficacy data are analyzed, and significant difference (is shown in Table 1).2. the GI sum before the treatment of index of gingivitis (GI): treatment group is 91.02,
Average is 2.62；10d after treatment, GI sum be 27.58 averages be 0.79.Illustrate drastically to decline with GI after this Dentifrice treatment.③
In periodontal pocket, antibacterial situation of change is shown in Table 2.
Table 1 therapeutic combination matched group comparitive study
Antibacterial situation of change (%) in periodontal pocket before and after the group treatment of 2 liang of table
Embodiment 12
The present embodiment the present invention is prepared toothpaste gingival hemorrhage, halitosis curative effect in terms of research experiment.
(1) test standard
Experimenter is NAM and the women of Pass Test standard.
Whole body health in order, gingival hemorrhage patient or halitosis patient；Can remember according to test requirements document during testing
Record also participates in inspection at any time；If women, trimester of pregnancy and age of sucking must not be in；Toothpaste and composition thereof will not be occurred
Quick；Do not use the medicine of other treatment gingival hemorrhage and halitosis；Participate in other similar experimental studies the most simultaneously.
(2) subjects
Age: 20-65 year.Select gingival hemorrhage patient 50 example, male 32 examples, female 18 example；Halitosis patient 50 example, male 22 examples,
Female 28 example.
Gingival hemorrhage
Use double-blind method random packet, be divided into treatment group (25 example) and matched group (25 example).The state of an illness of two groups of patients, sex,
Age aspect, through statistical procedures no significant difference (P > 0.05), has comparability.
Halitosis
Use double-blind method random packet, be divided into treatment group (25 example) and matched group (25 example).The state of an illness of two groups of patients, sex,
Age aspect, through statistical procedures no significant difference (P > 0.05), has comparability.
(3) test material
Test group: (gingival hemorrhage group and halitosis group all use prepared by the present invention to use the toothpaste prepared by the present invention
Toothpaste).
Matched group: homemade toothpaste.Prepared by the preparation technology preparing toothpaste according to the present invention, wherein, and plant basis
Quintessence oil is containing only Oleum menthae, without Oleum Eucalypti, Borneolum Syntheticum, Oleum Ocimi Gratissimi, Oleum Anisi Stellati, methyl salicylate, 6 kinds of quintessence oils of Mentholum.
(4) test method
Test group uses the toothpaste prepared by the present invention, and matched group uses homemade toothpaste.Morning every day, evening brush teeth each 1 time,
Continuing 5～10min, 10d is a course for the treatment of, disables other medicines during treatment every time.
(5) criterion of therapeutical effect
Notable (symptom the disappears substantially) B of A, effect, effective (improvement of symptom major part)
C, inconspicuous (not up to effectively standard or exacerbation of symptoms person)
(6) result of the test is shown in Table 3
Table 3 toothpaste of the present invention using effect statistical table
Statistical result from table 3 is it can be seen that present invention adds the toothpaste of plants essential oil mixture at treatment gingiva
Curative effect aspect hemorrhage, halitosis is significantly larger than matched group, and matched group is the toothpaste without plants essential oil mixture, this explanation,
The present invention toothpaste containing plants essential oil mixture has good curative effect at the treatment aspect such as gingival hemorrhage, halitosis.
Last institute is it should be noted that, the present invention is only protected by above example in order to technical scheme to be described
Protecting the restriction of scope, although being explained in detail the present invention with reference to preferred embodiment, those of ordinary skill in the art should
Understand, technical scheme can be modified or equivalent, without deviating from the essence of technical solution of the present invention
And scope.
Claims (8)
1. a toothpaste, it is characterised in that including plant basis quintessence oil and toothpaste matrix, described plant basis quintessence oil includes following
The component of weight portion: Borneolum Syntheticum 0.1～3 parts, Oleum Anisi Stellati 1～15 parts, Oleum Eucalypti 1～20 parts, methyl salicylate 10～80 parts, fourth
Fragrant basil oil 1～10 parts, Oleum menthae 10～80 parts, Mentholum 1～15 parts.
2. toothpaste as claimed in claim 1, it is characterised in that described plant basis quintessence oil includes the component of following weight portion:
Borneolum Syntheticum 0.1～1 part, Oleum Anisi Stellati 1～5 parts, Oleum Eucalypti 1～10 parts, methyl salicylate 20～50 parts, Oleum Ocimi Gratissimi 1～5
Part, Oleum menthae 20～50 parts, Mentholum 1～5 parts.
3. toothpaste as claimed in claim 2, it is characterised in that described plant basis quintessence oil includes the component of following weight portion:
Borneolum Syntheticum 0.42 part, Oleum Anisi Stellati 3.35 parts, Oleum Eucalypti 6.69 parts, methyl salicylate 41.84 parts, Oleum Ocimi Gratissimi 2.51 parts, thin
Lotus oil 41.84 parts, Mentholum 3.35 parts.
4. toothpaste as claimed in claim 1, it is characterised in that described toothpaste matrix comprises the component of following weight portion: friction
Agent 40～50 parts, adhesive 2～5 parts, wetting agent 20～25 parts, foaming agent 2～5 parts, resist 0～0.8 part, excipient 0.5
～1 part, solvent 15～25 parts, titanium dioxide 0.5～1 part, zinc chloride 0.03～0.1 part, saccharin 0.3～0.5 part, glycine
0.03～0.1 part.
5. toothpaste as claimed in claim 4, it is characterised in that described toothpaste matrix comprises the component of following weight portion: friction
Agent 45 parts, adhesive 3 parts, wetting agent 25 parts, foaming agent 3 parts, resist 0.3 part, excipient 0.6 part, solvent 22 parts, titanium dioxide
Titanium 0.5 part, zinc chloride 0.1 part, 0.4 part of saccharin, glycine 0.1 part.
6. toothpaste as claimed in claim 5, it is characterised in that described abrasivus is silicon dioxide；Described adhesive is starch；
Described wetting agent is glycerol；Described foaming agent is sodium lauryl sulphate；Described resist is waterglass；Described excipient is six
Hydrated magnesium chloride；Described solvent is deionized water.
7. the toothpaste as described in as arbitrary in claim 1～6, it is characterised in that described plant basis quintessence oil is in described toothpaste
Percentage by weight is 0.1%～5%, and described toothpaste matrix percentage by weight in described toothpaste is 95%～99.9%.
8. one kind as arbitrary in claim 1～7 as described in the preparation method of toothpaste, it is characterised in that described preparation method is:
(1) by the adhesive in toothpaste matrix composition, wetting agent and saccharin uniform dissolution in a solvent；
(2) in the solution that step (1) obtains, add other compositions in toothpaste matrix, uniformly mix；
(3) grinding, heat de-airing are to suitable viscosity；
(4) call in the plant basis quintessence oil of mix homogeneously, fill, packaging, obtain described toothpaste.
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| CN113456508A (en) * | 2021-07-02 | 2021-10-01 | 云南昭药健康产业有限公司 | Toothpaste containing blumea balsamifera extract and preparation method thereof |
| AU2019442226B2 (en) * | 2019-04-25 | 2023-05-18 | Colgate-Palmolive Company | Oral care compositions and methods of use |
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| CN102204875A (en) * | 2011-05-13 | 2011-10-05 | 义乌市爱尚日用品有限公司 | Total effect toothpaste and preparation method thereof |
| CN102871881A (en) * | 2012-10-12 | 2013-01-16 | 苏州谷力生物科技有限公司 | Antiphlogistic toothpaste |
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| CN109498490A (en) * | 2018-12-16 | 2019-03-22 | 丹东欣时代生物医药科技有限公司 | One kind dentifrice composition containing Artesunate and preparation method thereof |
| AU2019442226B2 (en) * | 2019-04-25 | 2023-05-18 | Colgate-Palmolive Company | Oral care compositions and methods of use |
| AU2019442226C1 (en) * | 2019-04-25 | 2023-11-30 | Colgate-Palmolive Company | Oral care compositions and methods of use |
| CN113456508A (en) * | 2021-07-02 | 2021-10-01 | 云南昭药健康产业有限公司 | Toothpaste containing blumea balsamifera extract and preparation method thereof |
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| CN106236612B (en) | 2020-06-26 |
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