CN111494409A

CN111494409A - Multifunctional medical mouthwash and preparation method thereof

Info

Publication number: CN111494409A
Application number: CN202010461932.1A
Authority: CN
Inventors: 卓颖
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-05-27
Filing date: 2020-05-27
Publication date: 2020-08-07

Abstract

The invention provides a multifunctional medical mouthwash and a preparation method thereof. The multifunctional medical mouthwash provided by the invention has multifunctional medical purposes of cleaning oral cavity, relieving oral discomfort symptom, diminishing inflammation and the like, and comprises the purposes of radioactive oral mucositis, oral ulcer after chemotherapy, recurrent aphthous ulcer and auxiliary drugs before oral cleaning or periodontal treatment, and is suitable for the purposes of relieving pain after oral treatment before and after oral treatment.

Description

Multifunctional medical mouthwash and preparation method thereof

Technical Field

The invention relates to the field of mouthwash, and particularly relates to multifunctional medical mouthwash and a preparation method thereof.

Background

Oral ulcers are the major organ of food intake, oral ulcers can occur either from self-limiting recurrent aphthas or from radiation-induced oral mucositis, and in recent years, oral ulcers resulting from the use of the chemotherapeutic methotrexate tablet have also become common. These mucosal inflammations in the oral area cause pain, aggravate eating difficulties, cause great troubles in daily life, and become mental burdens to patients. Since the oral cavity is the entrance of the digestive tract, the mode of administration is limited and the surface coating is difficult to stay on the surface. Therefore, the gargle can relieve the oral mucosa ulcer, can relieve the pain of the patient to a certain extent, can recover the normal eating activity, improves the life quality and reduces the mental trauma.

Moreover, the gargling mode reduces the side effect of the whole body use of the medicine, and meanwhile, the medicine can be freely controlled and mastered by the patient, so that the safety performance is higher and more convenient than other medicine modes. Along with the change of living habits of people in real life, the use of the mouthwash becomes a living habit of many people, and the mouthwash plays an increasingly important role in daily life. The technology has the advantages that the gargle is prepared by combining effective medicines, and the effects of cleaning the oral cavity and relieving symptoms are achieved by gargling.

Disclosure of Invention

In view of the above problems, the invention provides a multifunctional medical mouthwash and a preparation method thereof, aiming at solving the problem that the existing mouthwash is too single in function.

In order to achieve the purpose, the invention adopts the following technical scheme:

in a first aspect, the invention provides a multifunctional medical mouthwash, which at least comprises nimesulide and sodium fluoride, and the balance of the mouthwash is distilled water.

As an optional embodiment, the nimesulide is present in the mouthwash in an amount of 0.01 to 1% by weight.

As an alternative embodiment, the weight percentage of nimesulide in the mouthwash is 0.1%.

In an optional embodiment, the weight percentage of the sodium fluoride in the mouthwash is 0.02 to 0.5%.

As an alternative embodiment, the mouthwash further comprises lidocaine.

As an optional embodiment, the weight percentage of the lidocaine in the mouthwash is 0.5-5%.

As an optional embodiment, the weight percentage of lidocaine in the mouthwash is 2-4%.

As an alternative embodiment, the mouthwash further comprises ethanol and sorbitol; the weight percentage of the ethanol in the mouthwash is 10-20%; the weight percentage of the sorbitol in the mouthwash is 10-20%.

In a second aspect, the invention provides the use of the multifunctional medical mouth wash as described above for preparing radioactive oral mucositis, oral ulcer after chemotherapy, recurrent aphthous ulcer and adjuvant drug before oral cleaning or periodontal oral treatment.

In a third aspect, the invention provides a preparation method of the multifunctional medical mouthwash, and the preparation method comprises the following steps: uniformly mixing all the components of the mouthwash by stirring magnets within 0.5-2 hours, gradually adding distilled water, further stirring and mixing at 15-25 ℃ to obtain a clear liquid, and removing impurities through a filtering process to obtain the mouthwash.

The invention provides a multifunctional medical mouthwash and a preparation method thereof. The invention also provides a multifunctional medical mouthwash which has the multifunctional medical purposes of cleaning the oral cavity, relieving oral discomfort symptoms, diminishing inflammation and the like, and comprises the purposes of radioactive oral mucositis, oral ulcer after chemotherapy, recurrent aphthous ulcer and auxiliary medicines before oral cleaning or periodontal treatment, is suitable for the purposes of relieving pain after oral treatment before and after oral treatment, and increases applicability. In addition, the multifunctional medical mouthwash provided by the invention can relieve oral pain and discomfort and effectively improve fever and pain before oral treatment (low-dose lidocaine is added in the mouthwash) such as ultrasonic cleaning or periodontal treatment when a patient has recurrent aphthous ulcer, and the efficacy of the mouthwash is quickly exerted by ethanol, and no irritant reaction is generated on oral cells and tissues.

In order to make the aforementioned and other objects, features and advantages of the invention more comprehensible, preferred embodiments accompanied with figures are described in detail below.

Detailed Description

It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

The following merely represents selected embodiments of the invention, and all other embodiments obtained by a person skilled in the art on the basis of embodiments of the invention without making any inventive step are within the scope of protection of the present invention.

Example 1

A multifunctional medical gargle (hereinafter referred to as "gargle") at least comprises nimesulide and sodium fluoride, and the rest is distilled water. Nimesulide (Nimesulide) is a non-steroidal anti-inflammatory drug and can be clinically used for treating pain after operation and acute trauma and symptoms of primary dysmenorrhea. The nimesulide is applied to one of the components of the mouthwash before and after the oral operation, so that the pain of a patient before and after the oral operation can be effectively reduced. The sodium fluoride can play a role in preventing dental caries when added into the mouthwash, the risk of dental caries in the perioperative period is increased because patients are difficult to brush teeth normally after oral operation, and the sodium fluoride and the dental enamel can form fluorapatite on the surface of the dental enamel, thereby improving the hardness and the acid resistance of the dental enamel, reducing the formation of dental plaque and reducing the incidence rate of dental caries.

Example 2

In one embodiment of the mouthwash of the present invention, the weight percentage of nimesulide in the mouthwash is 0.01 to 1%, the weight percentage of sodium fluoride in the mouthwash is 0.02 to 0.5%, the weight percentage of lidocaine in the mouthwash is 0.5 to 5%, the weight percentage of ethanol in the mouthwash is 10 to 20%, and the weight percentage of sorbitol in the mouthwash is 10 to 20%. Wherein, the low dose of lidocaine can play the role of local anesthesia, has quick drug effect, has no any irritation to oral cells and tissues, and can relieve the pain of the oral cavity of a patient.

The preparation method of the mouthwash provided in this example is as follows:

according to the weight parts, the mouthwash is obtained after the ingredients are fully mixed in the proportion range (the ingredients of the mouthwash at least comprise nimesulide, sodium fluoride, lidocaine, ethanol and sorbitol) are uniformly mixed by stirring magnets within the time range of 0.5-2 hours, distilled water is gradually added, the mixture is further stirred and mixed at the temperature of 15-25 ℃ to form clear liquid, and impurities are removed through a filtering process. The mouthwash provided by the invention can be used for treating recurrent aphthous ulcer of a patient, and can be used for increasing low-dose lidocaine in the mouthwash before oral treatment, so that the pain relieving effect is enhanced, after multiple tests, if the patient is subjected to ultrasonic cleaning treatment or periodontal treatment, the discomfort caused by oral pain is effectively relieved, the antipyretic and analgesic effects are improved, the drug effect of the mouthwash is fast to play, and no irritation reaction is generated on oral cells and tissues.

Example 3

In one embodiment of the mouthwash provided by the invention, the weight percentage of nimesulide in the mouthwash is 0.1%, the weight percentage of sodium fluoride in the mouthwash is 0.1%, the weight percentage of lidocaine in the mouthwash is 2-4%, the weight percentage of ethanol in the mouthwash is 10-20%, and the weight percentage of sorbitol in the mouthwash is 10-20%.

The preparation method of the mouthwash in the embodiment comprises the following steps:

according to the weight parts, the components of the mouthwash are fully mixed (the components of the mouthwash at least comprise nimesulide, sodium fluoride, lidocaine, ethanol and sorbitol) by stirring magnets, the mixture is uniformly mixed within the time range of 1 hour, distilled water is gradually added, the mixture is further stirred and mixed at the temperature of 20 ℃ to obtain clear liquid, and impurities are removed through a filtering process to obtain the mouthwash. For example, the filtration procedure may be filtration through a 1 micron pore size filter paper.

Example 4

In order to prove that the mouthwash provided by the invention has the effects of diminishing inflammation, inhibiting bacteria and relieving pain, and can be used for assisting in treating the radioactive oral mucositis, the oral ulcer after chemotherapy, the recurrent aphthous ulcer, the application of auxiliary medicines before oral cleaning or periodontal treatment and the like, the embodiment combines experimental research to prove that the multifunctional medical mouthwash provided by the invention and comprising nimesulide and/or lidocaine can have considerable effects on treating the radioactive oral mucositis, the oral ulcer after chemotherapy, the recurrent aphthous ulcer and the application of the auxiliary medicines before oral cleaning or periodontal treatment.

Control group: mouthwash (without nimesulide and lidocaine, other preparation methods are the same as those provided by the invention);

test groups: according to the formula, for example, formulas such as 'ephedra powder' and the like in the traditional Chinese medicine can be combined, the 'fire depression' theory of aphtha in the traditional Chinese medicine is taken as a basis, and at least one of honeysuckle, jasmine roots, angelica dahurica or aloe can be combined.

Study subjects: 50 patients with radiation mucositis who are seen in the oral hospital and are willing to participate in the test are selected, and the age range is 18-52 years. 25 of the cases were male and 25 of the cases were female. The evaluation of the mucositis refers to the American radiation therapy oncology group, the oral mucositis grading standard and the oral mucositis is graded as 5. Stage 1: congestion, mild pain, no pain in the analgesic, but no effect on eating; stage 2: mucositis in the form of a sheet, with inflammatory or bloody exudation, moderate pain, requiring analgesics, and a semi-fluid diet; stage 3: the erythema on the mucosa is obvious, the pain is aggravated, and the powder is scattered on the ulcer; and 4, stage: mucosal ulcer and pain are more obvious than grade 2, and only fluid diet can be supplied; stage 5: mucosal ulcers fuse into a sheet, are painful and do not eat food.

In 50 cases, patients with radiation mucositis were randomly divided into a test group and a control group with an average population distribution, and the test group was asked to gargle 20ml of mouthwash for 3 minutes in groups before eating after the basic oral care was completed every morning and evening. Patients in the control and test groups required a uniform toothpaste and toothbrush. After 2 weeks, the plaque index, gum index and bleeding index examinations and Visual pain index (VAS) results of the patients of the control group and the test group were compared, respectively. After 2 weeks, the plaque index, gum index and bleeding index and VAS of the patients in the test group were respectively reduced by 9.57%, 12.33%, 28.85%, 34.67% compared to the patients in the control group. From the data, the multifunctional medical mouthwash comprising nimesulide and/or lidocaine provided by the invention can have a considerable inhibiting effect on the treatment of radioactive oral mucositis, oral ulcer after chemotherapy, recurrent aphthous ulcer and the application of auxiliary medicines before oral scaling or periodontal treatment.

In this example, the treatment effect of the mouthwash prepared by the invention on recurrent oral ulcer is studied and analyzed. 50 patients with oral ulcer and recurrent aphthous ulcer are selected, wherein 28 men and 22 women are treated by 2 tablets of vitamin B, and 2 tablets are taken after 3 meals a day. The test group was administered the mouthwash provided by the present invention for 3 minutes and 3 meals a day before, and then spit out. The patients in the control group and the patients in the test group were treated for 2 weeks.

In this example, the total effective rate of the test group with significant efficacy can be as high as 92.5% (mostly distributed in the 1 st to 2 nd levels). The total effective rate of the curative effect of the control group is only 43.3 percent (most of the effective rate is distributed in grades 2-3), the data of the curative effect after the treatment of the patients of the control group and the patients of the test group have obvious difference, and the difference value can be as high as 5, so that the multifunctional medical mouthwash comprising nimesulide and/or lidocaine provided by the invention can have quite remarkable pain inhibition effect on the treatment of radioactive oral mucositis, oral ulcer after chemotherapy, recurrent aphthous ulcer and the application of auxiliary medicines before oral cleaning or periodontal treatment.

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention are clearly and completely described above with reference to the examples in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention.

Thus, the above detailed description of embodiments of the invention is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims

1. The multifunctional medical mouthwash is characterized by at least comprising nimesulide and sodium fluoride, and the balance of distilled water.

2. The mouthwash according to claim 1, wherein the nimesulide is present in the mouthwash in an amount of 0.01 to 1% by weight.

3. The mouthwash according to claim 2, wherein the nimesulide is present in the mouthwash in an amount of 0.1% by weight.

4. The mouthwash according to claim 1, wherein the weight percentage of the sodium fluoride in the mouthwash is 0.02 to 0.5%.

5. The mouthwash of claim 1, further comprising lidocaine.

6. The mouthwash according to claim 5, wherein the lidocaine is present in the mouthwash in an amount of 0.5-5% by weight.

7. The mouthwash of claim 6, wherein the lidocaine is present in the mouthwash in an amount of 2-4% by weight.

8. The mouthwash of claim 1, wherein the mouthwash further comprises ethanol and sorbitol; the weight percentage of the ethanol in the mouthwash is 10-20%; the weight percentage of the sorbitol in the mouthwash is 10-20%.

9. Use of the multifunctional medical mouthwash according to any one of claims 1 to 8 as an adjuvant drug for the preparation of radioactive oral mucositis, post-chemotherapy oral ulcers, recurrent aphthous ulcers and for oral scaling or pre-periodontal treatment.

10. The preparation method of the multifunctional medical mouthwash according to any one of claims 1 to 8, wherein the preparation method comprises the following steps: uniformly mixing the components of the mouthwash by stirring magnets within the time range of 0.5-2 hours, gradually adding distilled water, further stirring and mixing at 15-25 ℃ to obtain a clear liquid, and removing impurities through a filtering process to obtain the mouthwash.