CN104666321B - It is a kind of to be used to treat pad pasting of canker sore and preparation method thereof - Google Patents
It is a kind of to be used to treat pad pasting of canker sore and preparation method thereof Download PDFInfo
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- CN104666321B CN104666321B CN201510053409.4A CN201510053409A CN104666321B CN 104666321 B CN104666321 B CN 104666321B CN 201510053409 A CN201510053409 A CN 201510053409A CN 104666321 B CN104666321 B CN 104666321B
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Abstract
The invention discloses a kind of pad pasting for being used to treat canker sore and preparation method thereof.The pad pasting uses water or weak caustic solution as decentralized medium using curdlan as film forming agent, contains curdlan 1g~10g per 100mL water or in weak caustic solution, berberine 0.4g~5g, astaxanthin 0.5g~2g, asiaticosid 0.5g~5g, steviol glycoside 0.02g~0.1g and vitamin B2 1g~8g.Preparation method is：Curdlan is added in water or weakly alkaline solution, stirring forms suspension；Berberine, asiaticosid, astaxanthin, steviol glycoside and vitamin B2 are added in curdlan suspension, stirs and evenly mixs to form dispersion liquid or colloid；Plastic film mulch, drying on polyfluortetraethylene plate by dispersion liquid or colloid.Using natural macromolecule amylose curdlan as filmogen compound a variety of active skull cap components, oral film is made in the present invention, has antibacterial, anti-inflammatory, analgesic, rush wound healing and other effects, has no toxic side effect；Pad pasting preparation technology flow is simple, and cost is low.
Description
Technical field
It is more particularly to a kind of can obtain so the present invention relates to a kind of pad pasting and preparation method thereof for being used to treat canker sore
Glue is the pad pasting of the treatment canker sore of film forming agent.
Background technology
Canker sore is a kind of common oral disease, shows as single or multiple superficial pain ulcer.Oral ulcer
The cause of disease is complicated, more relevant with virus and bacteria infection, hypovitaminosis, endocrine factors, immunologic function etc..It is clinical often outer with part
Medication and oral drugs are combined method and treated.Local topical medical instrument has rapid-action, Small side effects, can quickly repair mucous membrane
Advantage.Pad pasting is a kind of novel form of local topical medicine, and medicine is dissolved or is dispersed in filmogen softness is made
Film, there is good applicating property, can be directly used for affected part, have positioning, targeted release the characteristics of, drug utilization can be improved
Degree.But at present there is the problem of function effective components are single in oral film class product, or containing only vitamins, or containing only antibacterial
Anti-inflammation drugs etc..Because canker sore cause of disease complexity is various, the component of simple function make it that curative effect is not good enough, treatment cycle length.Have
Though a little pad pastings contain multiple efficacies composition, complex manufacturing technology.
The content of the invention
To be solved by this invention is that existing oral film class product function effective components are single, and curative effect is not good enough, treatment week
Phase is grown, the problem of the complex manufacturing technology of multiple efficacies pad pasting.
In order to solve the above problems, the invention provides a kind of pad pasting for being used to treat canker sore, it is characterised in that institute
Pad pasting is stated using curdlan as film forming agent, uses water or weak caustic solution as decentralized medium, is contained per 100mL water or in weak caustic solution
Following component：
Curdlan 1g~10g, berberine 0.4g~5g, asiaticosid 0.5g~5g, astaxanthin 0.5g~2g, stevioside
Glycosides 0.02g~0.1g and vitamin B2 1g~8g.
Present invention also offers it is above-mentioned be used for treat canker sore pad pasting preparation method, it is characterised in that including with
Lower step：
Step 1)：Curdlan is added in water or weakly alkaline solution, at room temperature in being stirred on homogenizer, is allowed to shape
Into stable suspension；
Step 2)：Berberine, asiaticosid, astaxanthin, stevia rebaudianum are added in curdlan suspension prepared by step 1)
Glucosides and vitamin B2, stirred and evenly mixed under conditions of 20 DEG C~80 DEG C, be allowed to form uniform dispersion liquid or colloid；
Step 3)：Dispersion liquid or the colloid plastic film mulch on polyfluortetraethylene plate prepared by step 2), it is put into drying box and adds
Heated drying.
Preferably, the weakly alkaline solution in the step 1) for 0.5%~1% mass concentration sodium citrate solution,
The sodium acetate solution of the sodium lactate solution of 0.5%~1% mass concentration or 0.5%~1% mass concentration.
Preferably, the design parameter of film drying is in the step 3)：2~5h is dried at 90~105 DEG C.
Preferably, after positive and negative respectively irradiates 15min under uviol lamp after the completion of the film in the step 3) is dried, packaging is close
Envelope.
The present invention is using curdlan good film forming, edibility and biological activity, with reference to berberine, centella
Glycosides, the anti-inflammation of astaxanthin and vitamin B2, rush cell metabolism and wound healing, the immunoregulatory ability of enhancing, there is provided
A kind of film for treating oral ulcer with complex function.
The curdlan that the present invention uses is the exocellular polysaccharide as caused by the bacterial fermentation of Agrobacterium, using glucose as
The linear macromolecule that construction unit is formed by β -1, the link of 3-D- glucoside bonds, relative molecular weight is about 6~2,000,000.
U.S. FDA in 1996 have approved curdlan as a kind of food additives.Curdlan, which has to be formed in a heated condition, to coagulate
The characteristic of glue, therefore also referred to as thermal gels.Two kinds of heterogeneitys of low-intensity gel and high-strength gel can be divided into according to degree of heat
Colloid.The gel for being heated to be obtained after 55 DEG C of coolings is low-intensity, heat-convertible gel；Be heated to more than 80 DEG C cool down again after
The gel obtained is high fixing glue, this gel heat irreversible, and gel strength is high.Curdlan can be used as gel in food
Agent, structure modifier, water binding agent, film forming agent, binder, thickener, stabilizer etc..On medical industry, curdlan has
Antitumor, antibacterium and the pharmacological activity such as antiviral.Curdlan good film-forming property, curdlan film have that dilatancy is good, intensity
The features such as high.
The berberine also known as jamaicin that the present invention uses, the master extracted in the root-like stock for being the Ranunculaceae coptis plant coptis
Want active ingredient.Berberine is clinically mainly used in the treatment of enteric infection, and discovered in recent years berberine has antibacterial, disappeared
Inflammation, a variety of effects such as nospecific immunity can be strengthened.
The asiaticosid that the present invention uses is active component main in traditional Chinese medicine centella, and modern pharmacology research is demonstrate,proved
Real its has anti-inflammatory, antiulcer, promotees a variety of pharmacological activity such as wound healing, removing toxicity for detumescence.
The astaxanthin that the present invention uses is derived from a species Hu trailing plants of the biology such as shellfish, algae and phaffia rhodozyma
Bu Su, there is superpower antioxidation activity, oxygen radical that can effectively in scavenger-cell, strengthen cytothesis ability, mitigate ulcer
Pain symptom.Astaxanthin also has the effects such as immune, the promotion growth and breeding of enhancing, in the row such as food, medicine, cosmetics and feed
Industry plays an important roll.
The vitamin B2 that the present invention uses is the prothetic group of the important oxidoreducing enzyme of some in body, participates in the growth generation of cell
Thank, be injected organism tissue metabolism and the essential nutrients repaired.
The steviol glycoside that the present invention uses can adjust the mouthfeel of pad pasting, and do not cause carious tooth as a kind of sweetener.
The present invention using natural macromolecule amylose curdlan as filmogen, compound berberine, asiaticosid, astaxanthin,
A variety of active skull cap components such as vitamin B2 and steviol glycoside, are made oral film, the pad pasting with antibacterial, anti-inflammatory, only
Bitterly, promote wound healing and other effects, have no toxic side effect；Pad pasting preparation technology flow is simple, and cost is low.
Embodiment
To become apparent the present invention, hereby with preferred embodiment, it is described in detail below.
Embodiment 1
First, it is formulated
Raw materials used composition is：Curdlan 5g, berberine 5g, asiaticosid 1g, astaxanthin 1g, steviol glycoside 0.08g,
Vitamin B2 6g, water 100ml.
2nd, preparation method
5g curdlans are weighed, are added in 100ml water, at room temperature in stirring on homogenizer, are allowed to form stabilization
Suspension；
Berberine, asiaticosid, astaxanthin, steviol glycoside and vitamin B2 are weighed, is added in curdlan suspension,
Stirred and evenly mixed at 50 DEG C, be allowed to form uniform dispersion liquid；
Obtained dispersion liquid plastic film mulch on polyfluortetraethylene plate, 3h film forming is dried in 90 DEG C of drying boxes；
Obtained film positive and negative under uviol lamp respectively irradiates 15min, package encapsulation.
Embodiment 2
First, it is formulated
Raw materials used composition is：Curdlan 8g, berberine 3g, astaxanthin 0.5g, asiaticosid 3g, steviol glycoside
0.06g, vitamin B2 3g, water 100ml.
2nd, preparation method
8g curdlans are weighed, are added in 100ml water, at room temperature in stirring on homogenizer, are allowed to form stabilization
Suspension；
Berberine, asiaticosid, astaxanthin, steviol glycoside and vitamin B2 are weighed, is added in curdlan suspension,
Stirred and evenly mixed at 70 DEG C, be allowed to form uniform colloid；
Obtained colloid plastic film mulch on polyfluortetraethylene plate, 2.5h film forming is dried in 100 DEG C of drying boxes；
Obtained film positive and negative under uviol lamp respectively irradiates 15min, package encapsulation.
Embodiment 3
First, it is formulated
Raw materials used composition is：Curdlan 6g, berberine 4g, astaxanthin 0.8g, asiaticosid 2g, steviol glycoside
0.08g, vitamin B2 1.5g, 0.7% sodium citrate solution 100ml.
2nd, preparation method
6g curdlans are weighed, adds in 0.7% sodium citrate solution, at room temperature in being stirred on homogenizer, is allowed to
Form stable suspension；
Weigh berberine, asiaticosid, astaxanthin, steviol glycoside and vitamin B2, be added in curdlan suspension,
Stirred and evenly mixed at 30 DEG C, be allowed to form uniform dispersion liquid；
Obtained dispersion liquid plastic film mulch on polyfluortetraethylene plate, 2h film forming is dried in 90 DEG C of drying boxes；
Obtained film positive and negative under uviol lamp respectively irradiates 15min, package encapsulation.
Embodiment 4
First, it is formulated
Raw materials used composition is：Curdlan 9g, berberine 3g, astaxanthin 1.5g, asiaticosid 3g, steviol glycoside
0.06g, vitamin B2 2g, 0.9% sodium lactate solution 100ml.
2nd, preparation method
6g curdlans are weighed, adds in 0.9% sodium lactate solution, at room temperature in being stirred on homogenizer, is allowed to shape
Into stable suspension；
Berberine, asiaticosid, astaxanthin, steviol glycoside and vitamin B2 are weighed, adds people into curdlan suspension,
Stirred and evenly mixed at 60 DEG C, be allowed to form uniform dispersion liquid；
Obtained dispersion liquid plastic film mulch on polyfluortetraethylene plate, 2h film forming is dried in 100 DEG C of drying boxes；
Obtained film positive and negative under uviol lamp respectively irradiates 15min, package encapsulation.
Embodiment 5
First, it is formulated
Raw materials used composition is：Curdlan 10g, berberine 2g, astaxanthin 2g, asiaticosid 4g, steviol glycoside
0.05g, vitamin B2 4g, 1% sodium acetate solution 100ml；
2nd, preparation method
6g curdlans are weighed, are added in 1% sodium acetate solution, at room temperature in being stirred on homogenizer, are allowed to
Form stable suspension；
Berberine, asiaticosid, astaxanthin, steviol glycoside and vitamin B2 are weighed, is added in curdlan suspension,
Stirred and evenly mixed at 50 DEG C, be allowed to form uniform dispersion liquid；
Obtained dispersion liquid plastic film mulch on polyfluortetraethylene plate, 2h film forming is dried in 90 DEG C of drying boxes；
Obtained film positive and negative under uviol lamp respectively irradiates 15min, package encapsulation.
The therapeutic effect of oral film of the present invention
Canker sore patient 26 is chosen, is randomly divided into experimental group and control group, every group each 13.With the embodiment of the present invention
3 oral films prepared are experimental group, using commercially available oral film as control group, pad pasting are attached into ulcer affected part, two groups are
3 times a day, 7 days are a course for the treatment of.
Efficacy determination
Cure：Pain disappears, ulcer surface healing；Effectively：Pain relief, ulcer surface reduce；It is invalid：Symptom is without obvious good
Turn, ulcer surface is without being obviously reduced.
As can be seen from Table 1 and Table 2, the film for treating oral ulcer treatment time that prepared by the present invention shortens, and treated effect carries
It is high.
The different time symptom improvement situation of table 1
The therapeutic effect of table 2 compares
Claims (4)
1. a kind of pad pasting for being used to treat canker sore, it is characterised in that the pad pasting is using curdlan as film forming agent, using water
Or weak caustic solution is decentralized medium, contain following component per 100mL water or in weak caustic solution：
Curdlan 1g ~ 10g, berberine 0.4g ~ 5g, astaxanthin 0.5g ~ 2g, asiaticosid 0.5g ~ 5g, steviol glycoside 0.02g ~
0.1g and vitamin B2 1g ~ 8g；
The described pad pasting for being used to treat canker sore is made by following steps：
Step 1）：Curdlan is added in water or weakly alkaline solution, at room temperature in stirring on homogenizer, is allowed to be formed surely
Fixed suspension；
Step 2）：In step 1）Berberine, asiaticosid, astaxanthin, steviol glycoside are added in the curdlan suspension of preparation
And vitamin B2, stirred and evenly mixed under conditions of 20 DEG C ~ 80 DEG C, be allowed to form uniform dispersion liquid or colloid；
Step 3）：By step 2）The dispersion liquid or colloid of preparation plastic film mulch on polyfluortetraethylene plate, it is put into heat in drying box and does
It is dry；
The step 1）In weakly alkaline solution be the sodium citrate solution of 0.5% ~ 1% mass concentration, 0.5% ~ 1% mass concentration
The sodium acetate solution of sodium lactate solution or 0.5% ~ 1% mass concentration.
A kind of 2. preparation method for being used to treat the pad pasting of canker sore described in claim 1, it is characterised in that the pad pasting
Using curdlan as film forming agent, water or weak caustic solution are used as decentralized medium, and following group is contained per 100mL water or in weak caustic solution
Part：
Curdlan 1g ~ 10g, berberine 0.4g ~ 5g, astaxanthin 0.5g ~ 2g, asiaticosid 0.5g ~ 5g, steviol glycoside 0.02g ~
0.1g and vitamin B2 1g ~ 8g；
The preparation method of the pad pasting for treating canker sore comprises the following steps：
Step 1）：Curdlan is added in water or weakly alkaline solution, at room temperature in stirring on homogenizer, is allowed to be formed surely
Fixed suspension；
Step 2）：In step 1）Berberine, asiaticosid, astaxanthin, steviol glycoside are added in the curdlan suspension of preparation
And vitamin B2, stirred and evenly mixed under conditions of 20 DEG C ~ 80 DEG C, be allowed to form uniform dispersion liquid or colloid；
Step 3）：By step 2）The dispersion liquid or colloid of preparation plastic film mulch on polyfluortetraethylene plate, it is put into heat in drying box and does
It is dry；
The step 1）In weakly alkaline solution be the sodium citrate solution of 0.5% ~ 1% mass concentration, 0.5% ~ 1% mass concentration
The sodium acetate solution of sodium lactate solution or 0.5% ~ 1% mass concentration.
3. the preparation method as claimed in claim 2 for being used to treat the pad pasting of canker sore, it is characterised in that the step 3）
The design parameter that middle film is dried is：2 ~ 5h is dried at 90 ~ 105 DEG C.
4. the preparation method as claimed in claim 2 for being used to treat the pad pasting of canker sore, it is characterised in that the step 3）
In film dry after the completion of after positive and negative respectively irradiates 15min under uviol lamp, package encapsulation.
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| CN201510053409.4A CN104666321B (en) | 2015-02-02 | 2015-02-02 | It is a kind of to be used to treat pad pasting of canker sore and preparation method thereof |
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| CN104666321B true CN104666321B (en) | 2018-01-19 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101325961A (en) * | 2005-11-28 | 2008-12-17 | 以瓦伦萨国际营业的美国营养品有限公司 | Algal and algal extract dietary supplement composition |
| CN102198126A (en) * | 2011-05-04 | 2011-09-28 | 刘布鸣 | Liniment for treating mouth and tooth diseases and applicator |
| CN103340797A (en) * | 2013-07-15 | 2013-10-09 | 柳州两面针股份有限公司 | Application of centella extract in Chinese medicinal toothpaste |
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2015
- 2015-02-02 CN CN201510053409.4A patent/CN104666321B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101325961A (en) * | 2005-11-28 | 2008-12-17 | 以瓦伦萨国际营业的美国营养品有限公司 | Algal and algal extract dietary supplement composition |
| CN102198126A (en) * | 2011-05-04 | 2011-09-28 | 刘布鸣 | Liniment for treating mouth and tooth diseases and applicator |
| CN103340797A (en) * | 2013-07-15 | 2013-10-09 | 柳州两面针股份有限公司 | Application of centella extract in Chinese medicinal toothpaste |
Non-Patent Citations (2)
| Title |
|---|
| 口腔溃疡膜的研究进展及临床应用;梁希月等;《中国民族民间医药杂志》;19981231(第32期);第8-11页 * |
| 可得然胶的性质及应用;张海龙等;《中国食品与营养》;20101231(第1期);第36-39页 * |
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Address after: 201620 No. 2999 North Renmin Road, Shanghai, Songjiang District Patentee after: DONGHUA University Patentee after: TAIXING DONGSHENG BIO-TECH CO.,LTD. Address before: 201620 No. 2999 North Renmin Road, Shanghai, Songjiang District Patentee before: DONGHUA University Patentee before: TAIXING DONGSHENG FOOD TECHNOLOGY CO.,LTD. |