CN1895293A - Spirulina oral tablet for supplementing human-body nutrients and its preparation - Google Patents
Spirulina oral tablet for supplementing human-body nutrients and its preparation Download PDFInfo
- Publication number
- CN1895293A CN1895293A CNA2006100880030A CN200610088003A CN1895293A CN 1895293 A CN1895293 A CN 1895293A CN A2006100880030 A CNA2006100880030 A CN A2006100880030A CN 200610088003 A CN200610088003 A CN 200610088003A CN 1895293 A CN1895293 A CN 1895293A
- Authority
- CN
- China
- Prior art keywords
- spirulina
- mixing
- disintegrating tablet
- tablet formulation
- oral disintegrating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
An oral disintegrating spirulina tablet for providing nutrients to human body is prepared from spirulina, microcrystalline cellulose (MCC) cross-linked polyvinyl pyrrolidone (PVPP), low-substituted hydroxypropyl cellulose (L-HPC), mannitol, magnesium stearate and sweetening agent through grinding, mixing, sieving and die pressing.
Description
One, technical field
The present invention relates to Chinese medicine preparation and food processing manufacture technology field, specifically relate to spirulina oral cavity disintegration tablet that can replenish the human nutrition element and preparation method thereof.
Two, background technology
Spirulina is human nutritional labeling fullest known today, the most comprehensive, the most balanced, the natural energetic nourishing product that the most easily are absorbed by the body.Spirulina is that protein content is the highest in the microalgae (chlorella, chlorella and spirulina) commonly used at present, nutrition is the most comprehensive, it is best to digest and assimilate with palatability, have no side effect (comprising frond and culture medium), the highest algae kind of safety.Both can be used as protein raw material, can be used as the additive of food and feedstuff again.
The nutritive value of spirulina is:
(1) the protein content height, form reasonable spirulina protein content up to 60%～70%, and protein quality is good, is easy to digest and assimilate, do not contain the factor that any obstruction is digested and assimilated.At least contain 18 kinds in the hydrolysis of protein spirulina with upper amino acid, its amino acid pattern is more satisfactory, and it is low slightly to remove sulfur amino acid content, and the necessary 8 kinds of essential amino acids content of animal body are abundant, near the ratio of FAO.Because cellulose is few in the cell wall structure, is digested and assimilated by humans and animals easily.
(2) carbohydrate content is moderate, component is special
Carbohydrate accounts for 15%～20% of spirulina cells dry weight, is mainly the dendritic polysaccharide of branch.Wherein mannose 7%～9%, methyl sugar 7%, and alginic acid 24%～29%, rhamnose 3%～6% is not determined sugar 14.4%.Its component is different from the conventional plant forage, and especially alginic acid, mannitol are that the precious animal of Aquatic product institute is essential, contained polysaccharide have regulate and human body immunity improving power, but cancer and radiation resistance, it can be worth and is 10.46MJ/kg.
(3) fiber content is few in the cell wall
Spirulina frond cell wall mainly is made up of crude protein, and content of cellulose only is 4%～5%, and therefore, need not any processed can be digested and assimilated by animal, and digestibility surpasses 75%, and especially as the open-mouthed bait of prawn, effect is better.
(4) unsaturated fatty acid proportion height, quality better
The report of relevant spirulina fat content differs greatly, and scope accounts for 1.5%～12% of dry weight, but is generally 5%～6%, and wherein 70%～80% is unsaturated fatty acid.Essential fatty acid such as gamma-Linolenic acid (EFA) content height accounts for 1.1% of dry weight.Gamma-Linolenic acid is the EFA of aquatic products such as prawn, and it not only has growth promoting function, but but also enhancing body premunition.The sterols that spirulina is contained mainly is high-quality cholesterol and cupreol, has effects such as enhancing human body immunity power, delaying cell aging, cholesterol reducing, and is also relevant with the antimicrobial acivity of spirulina.
(5) vitamin content height
The vitamin content of spirulina is abundant, and nearly 13 kinds of kinds are especially with carotenoid, B
1, B
2, B
6, B
12, V
cDeng functional vitamin is main.Spirulina contains abundant carotenoid (0.2%～0.4%), is 10～15 times of other plant (comprising Radix Dauci Sativae).It is higher that carotenoid absorbs conversion ratio in animal body, can reach good coloring effect after the conversion, thereby can improve the commodity value of shrimp, precious marine product, pet fish, house pet, broiler and egg etc.In addition, beta-carotene is V
APrecursor, V
AHave human body immunity improving power, prevent epithelial cell canceration, strengthen cell membrane toughness, strengthen the resistance of pair cell and der Pilz disease and, thereby effectively improve the survival rate of young animal the tolerance of low-oxygen environment.Mikuton and Soin (1975) find that the carotenoid digestion amount during fetal development in the yolk sac is quite big, just know by inference, and the height of carotenoid content is relevant with the hatching survival rate.Carotenoid still is a kind of Natural antioxidant, and is similar to the alpha-tocopherol effect, and protection sensitive organization and reflection chemical compound are subjected to oxidative damage.
(6) abundant, the easily absorption of content of mineral substances
The contained mineral element kind of spirulina has kind more than 50, content enriches and is easy to absorb, especially be rich in iodine 520～580mg/kg, potassium 1700～2200mg/kg, sodium 15000～18000mg/kg, ferrum 475～580mg/kg, and these mineral exist with the chelating state in frond, be easy to digest and assimilate, digestive utilization ratio is very high.
(7) bioactive substance
Bioactive substance contained in the spirulina can directly promote digesting and assimilating of nutrient substance, has the function of multiple non-nutritive additive: 1) contain plurality of enzymes, can promote digesting and assimilating of nutrient substance, thereby improve efficiency of feed utilization.2) contain the UGF that promotes growth of animal.3) contain immune material and the anti-heat stress acting factor that improves animal immune ability and resistance against diseases.4) contain bioactive hormone and the anti-bacteria and anti-virus material thereof that the regulation and control organism metabolism is played an important role, have the function of preventing and curing diseases.
The spirulina range of application of China mainly is: (1) spirulina food: two class spirulina foods are arranged at present, and a class is that pure spirulina processes, and algae sheet, capsule are arranged; One class is for to add Spirulina powder in the food, and product has instant noodles, nutritive cube, beverage, cake, fancy noodles etc.(2) precious marine product feedstuff: spirulina substituting import one feedstuff, can promote the growth of precious marine product, improve survival rate, strengthen resistance against diseases.(3) medicinal research: spirulina can be used as the ancillary drug of the multiple disease of treatment.For example the leukopenia immunologic hypofunction of the Shi Purui capsule in Yunnan after to hyperlipidemia, radiotherapy chemotherapy all has significant curative effect.China Radiation Medical Science Inst., Chinese Academy of Military Medical Science (CN studies show that, spirulina has remarkable result to the treatment radiation damage.
Spirulina deep processing prospect is tempting: extract phycocyanobilin from spirulina, as the natural pigment of food, cosmetics; Spirulina polysaccharide can strengthen the immunity of biologic artifact; Spirulina biliprtein can be used as fluorescent probe of new generation, for treatment provides new diagnostic means; Can also from spirulina, extract defying age, radioprotective, anticancer medicine.
Although spirulina has so many benefit, because spirulina has special algae fishy smell, so be difficult to be accepted by many consumers.We are made into color and all good oral cavity disintegration tablets of shape with spirulina, have eliminated the algae fishy smell of spirulina, thereby have reached the effect of light health care, can satisfy consumers in general's demand, and its market prospect will be very broad.
Three, summary of the invention
1. goal of the invention
The object of the present invention is to provide the spirulina oral disintegrating tablet formulation that replenishes the human nutrition element, the spirulina oral disintegrating tablet formulation has taking convenience, absorbs soon, and the bioavailability height is to characteristics such as the digestive tract mucous membrane irritation are little.
Another object of the present invention provides spirulina oral disintegrating tablet formulation preparation method.
2, technical scheme
(1) raw material of spirulina oral disintegrating tablet formulation is formed and weight proportion.
A kind of spirulina oral disintegrating tablet formulation, it is characterized in that it is made by following materials of weight proportions: every consumption is spirulina 0.1～1.0g, microcrystalline Cellulose (MCC) 0.2～1.0g, crospolyvinylpyrrolidone (PVPP) 0.02～0.1g, low-substituted hydroxypropyl cellulose (L-HPC) 0.06～0.2g, mannitol 0.18～0.6g, magnesium stearate 0.006～0.02g, aspartame 0.01～0.03g.
(2) preparation method of spirulina oral disintegrating tablet formulation, its preparation process is:
1. take by weighing microcrystalline Cellulose (MCC) 0.2～1.0g, crospolyvinylpyrrolidone (PVPP) 0.02～0.1g, low-substituted hydroxypropyl cellulose (L-HPC) 0.06～0.2g, the equivalent incremental method grinds mixing, crosses 50 mesh sieves, mixing;
2. get mannitol 0.18～0.6g in addition, magnesium stearate 0.006～0.02g, aspartame 0.01～0.03g cross 50 mesh sieves, mixing respectively;
3. get spirulina 0.1～1.0g,, cross 50 mesh sieves its porphyrize;
4. with main constituent spirulina and above-mentioned steps 1., 2. adjuvant grinds mixing, crosses 50 mesh sieves, mixing, tabletting make the spirulina oral disintegrating tablet formulation.
3, beneficial effect
A large amount of scientific researches prove that spirulina contains multiple bioactive substance, have important health care, can be used as the ancillary drug of the multiple disease of treatment:
(1) spirulina has direct removing ability to oxygen-derived free radicals, can enhancing human body immunity power, have anticorrosion, anticancer, radioprotective, anti-aging effects.
(2) can stimulate the synthetic of prostaglandin, tool is regulated body physiological function.
(3) enhance metabolism, strengthen hemopoietic function, accelerating wound healing prevents skin keratinization.
(4) spirulina contains the useful factor that promotes lactobacillus, and is therefore, helpful to intestinal tract disease.The chlorophyll of spirulina and the difference that the haemachrome in the human body blood only has magnesium, iron ion can be converted into haemachrome by certain conversion process in human body simultaneously, therefore, diseases such as anemia are had good curative effect.Because above both comprehensive function, spirulina all has curative effect preferably to liver, kidney, diabetes).
(5) can recover organic agricultural chemicals poisoning patient's activity of cholinesterase.
(6) absorbability of spirulina is high, can replenish physical ability, to severe malnutrition patient's conditioning, to weak after being ill recovery, the child is had additional nutrients and care of aged, life lengthening all have special effect, also can be used for the additive that precious animal is raised the erbium material.The Zhou Aitang of Nanjing University shows with isotopic tracing: feed tame chicken and white mice with spirulina, their absorption rate is respectively 72% and 67%.Spirulina contains necessary R-linoleic acid of a large amount of human bodies and R-linolenic acid, therefore cholesterol in energy blood fat reducing and the blood, has positive effect to anti-angiocardiopathy, and its contents of saccharide is also lower, is the nutraceutical of good anoretic and diabetics.
Spirulina oral cavity disintegration tablet of the present invention can replenish the many important nutrients of human body, thereby reaches above-mentioned many useful effect.
Spirulina and corresponding auxiliary material are made oral disintegrating tablet formulation, its irreplaceable advantage is also arranged.The excellent characteristics of oral disintegrating tablet formulation: can not need water when (1) taking convenience oral cavity disintegration tablet is taken, disintegrate rapidly in the 15s does not have trapping phenomena in esophagus in the oral cavity.This provides great convenience for the patient of the difficult change of child, old people, some psychiatric patient and bed position.(2) absorbing fast, the high oral rapidly disintegrating characteristic of bioavailability increases the medicine absorption area, and absorbs easily, fast.(3) after the disintegrate of gastrointestinal mucosal stimulation osculum disintegrating tablet was swallowed, because of the saliva amount is few, drug particles was thin, can be at the stomach uniform distribution, and absorption or embedding gastric mucosa, absorbtivity increases, also can be because of the excessive generation stimulation of the local dose of gastric mucosa.
Four, the specific embodiment
The raw material of embodiment 1 spirulina oral disintegrating tablet formulation is formed and weight proportion
A kind of spirulina oral cavity disintegration tablet, it is to be made by following materials of weight proportions: every consumption is spirulina 0.6g, microcrystalline Cellulose (MCC) 0.6g, crospolyvinylpyrrolidone (PVPP) 0.6g, low-substituted hydroxypropyl cellulose (L-HPC) 0.1g, mannitol 0.2g, magnesium stearate 0.01g, aspartame 0.02g.
The preparation method of 2 one kinds of spirulina oral disintegrating tablet formulations of embodiment, its preparation process is:
(1) take by weighing microcrystalline Cellulose (MCC) 0.6g, crospolyvinylpyrrolidone (PVPP) 0.6g, low-substituted hydroxypropyl cellulose (L-HPC) 0.1g, the equivalent incremental method grinds mixing, crosses 50 mesh sieves, mixing;
(2) get mannitol 0.2g in addition, magnesium stearate 0.01g, aspartame 0.02g cross 50 mesh sieves, mixing respectively;
(3) get spirulina 0.6g,, cross 50 mesh sieves its porphyrize;
(4) with principal agent spirulina and above-mentioned steps 1., 2. adjuvant grinds mixing, crosses 50 mesh sieves, mixing, tabletting make the spirulina oral disintegrating tablet formulation.
Claims (3)
1, a kind of spirulina oral disintegrating tablet formulation, it is characterized in that it is to be made by following materials of weight proportions: every consumption is spirulina 0.1～1.0g, microcrystalline Cellulose 0.2～1.0g, crospolyvinylpyrrolidone 0.02～0.1g, low-substituted hydroxypropyl cellulose 0.06～0.2g, mannitol 0.18～0.6g, magnesium stearate 0.006～0.02g, aspartame 0.01～0.03g.
2, spirulina oral disintegrating tablet formulation according to claim 1 is characterized in that also can adding crospolyvinylpyrrolidone 0.02～0.1g again low-substituted hydroxypropyl cellulose 0.06～0.2g and aspartame 0.01～0.03g.
3, a kind of method for preparing claim 1 spirulina oral disintegrating tablet formulation, its preparation process is:
(1) take by weighing microcrystalline Cellulose 0.2～1.0g, crospolyvinylpyrrolidone 0.02～0.1g, low-substituted hydroxypropyl cellulose 0.06～0.2g grinds mixing, crosses 50 mesh sieves, and mixing is standby;
(2) get mannitol 0.18～0.6g in addition, magnesium stearate 0.006～0.02g, aspartame 0.01～0.03g cross 50 mesh sieves respectively, and mixing is standby;
(3) get spirulina 0.1～1.0g,, cross 50 mesh sieves its porphyrize;
(4) adjuvant with main constituent spirulina and above-mentioned (1), (2) step grinds mixing, crosses 50 mesh sieves, and mixing, tabletting make the spirulina oral disintegrating tablet formulation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100880030A CN1895293A (en) | 2006-06-16 | 2006-06-16 | Spirulina oral tablet for supplementing human-body nutrients and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100880030A CN1895293A (en) | 2006-06-16 | 2006-06-16 | Spirulina oral tablet for supplementing human-body nutrients and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1895293A true CN1895293A (en) | 2007-01-17 |
Family
ID=37608030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006100880030A Pending CN1895293A (en) | 2006-06-16 | 2006-06-16 | Spirulina oral tablet for supplementing human-body nutrients and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1895293A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485692B (en) * | 2009-03-03 | 2011-09-21 | 溧阳市天目湖保健品有限公司 | Method for pressing spirulina special-shaped tablets |
| CN105327360A (en) * | 2015-11-22 | 2016-02-17 | 威海百合生物技术股份有限公司 | Disintegrating agent for spirulina tablets |
| CN106265589A (en) * | 2016-08-31 | 2017-01-04 | 海南林恒制药股份有限公司 | A kind of spirulina complex capsule and preparation method thereof |
-
2006
- 2006-06-16 CN CNA2006100880030A patent/CN1895293A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485692B (en) * | 2009-03-03 | 2011-09-21 | 溧阳市天目湖保健品有限公司 | Method for pressing spirulina special-shaped tablets |
| CN105327360A (en) * | 2015-11-22 | 2016-02-17 | 威海百合生物技术股份有限公司 | Disintegrating agent for spirulina tablets |
| CN106265589A (en) * | 2016-08-31 | 2017-01-04 | 海南林恒制药股份有限公司 | A kind of spirulina complex capsule and preparation method thereof |
| CN106265589B (en) * | 2016-08-31 | 2019-01-01 | 海南林恒制药股份有限公司 | A kind of spirulina complex capsule and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100563457C (en) | Replenish Sugarless type spirulina hard candy and the soft sweets and the preparation method of human nutrition element | |
| CN108056325B (en) | Sea water black porgy feed with immunity enhancing function | |
| CN1742929A (en) | Chinese herbal medicinal immune intensifier mode from left-eyed flounder and right-eyed flounder | |
| CN109007224A (en) | A kind of pressed candy and preparation method thereof containing Astaxanthin In Haematococcus Pluvialis conditioning female organism | |
| CN105613918A (en) | Euglena compound tableting candy and preparation method thereof | |
| CN1224329C (en) | Feed additive made of herbal medicine compound concentrate, and its prepn. method | |
| KR101532208B1 (en) | Biogas residue containing chicken formula feed and the production method thereof | |
| CN1194703C (en) | Health-care food for protecting gastric mucosa and its preparing process | |
| CN100336893C (en) | Pumpkin red cordial and its brewing process | |
| CN110710660A (en) | Blood sugar lowering composition and dietary supplement containing bitter gourd powder | |
| CN1895293A (en) | Spirulina oral tablet for supplementing human-body nutrients and its preparation | |
| CN109170313A (en) | A kind of anti-heat stress egg feedstuff compound additive and preparation method thereof | |
| CN1842348A (en) | Galactomannans and/or glucomannans for increasing the bioavailability of active substances | |
| CN105166620A (en) | Horseradish tree composition capable of reducing blood lipid and preparation method of horseradish tree composition | |
| CN109007225A (en) | A kind of brown alga astaxanthin pressed candy and preparation method thereof | |
| CN105475622A (en) | Feed additive for improving egg production of meat ducks and feed thereof | |
| CN111280453B (en) | Preparation method of antrodia water-insoluble dietary fiber | |
| CN107549692A (en) | A kind of ocean polypeptide spy's dietary seafood for patients undergoing chemotherapy post-operative recovery | |
| CN1423961A (en) | Chitin healthy food and production thereof | |
| CN1092977C (en) | Anti-cancer medicine | |
| CN109198164A (en) | A kind of soft-shelled turtle feed and preparation method thereof | |
| CN1899299A (en) | Chitosan powder medicine for fishing and its producing process | |
| CN101053369A (en) | Feed additive for fowls and domestic animals and preparation method thereof | |
| CN1817226A (en) | Production of diet fibre with high activity | |
| CN1261103C (en) | Microbial drug material, its preparing method and usage |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |