CN110710660A - Blood sugar lowering composition and dietary supplement containing bitter gourd powder - Google Patents

Blood sugar lowering composition and dietary supplement containing bitter gourd powder Download PDF

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Publication number
CN110710660A
CN110710660A CN201910869050.6A CN201910869050A CN110710660A CN 110710660 A CN110710660 A CN 110710660A CN 201910869050 A CN201910869050 A CN 201910869050A CN 110710660 A CN110710660 A CN 110710660A
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powder
parts
blood glucose
composition
dietary supplement
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王开道
邱娟
王国强
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HUNAN KEER BIOTECHNOLOGY CO Ltd
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HUNAN KEER BIOTECHNOLOGY CO Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/01—Instant products; Powders; Flakes; Granules
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/09—Mashed or comminuted products, e.g. pulp, purée, sauce, or products made therefrom, e.g. snacks
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/113—Acidophilus
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/169—Plantarum
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/51—Bifidobacterium
    • A23V2400/513—Adolescentes

Abstract

The invention discloses a blood sugar reducing composition containing bitter gourd powder and a dietary supplement, wherein the composition comprises the following raw materials in parts by weight: 20-45 parts of bitter gourd powder; 15-40 parts of isomalt; 15-30 parts of resistant dextrin; 15-35 parts of inulin; 1-10 parts of momordica grosvenori powder; 1-5 parts of okra powder; 0.5-5% of probiotic compound. The invention utilizes the compounding among the raw materials, fully exerts the synergistic effect, and effectively reduces the blood sugar level by reducing/inhibiting the absorption of the body to glucose, improving the sensitivity of peripheral tissues to insulin, reducing the content of key enzyme in gluconeogenesis and increasing the content of key enzyme in pentose phosphate pathway.

Description

Blood sugar lowering composition and dietary supplement containing bitter gourd powder
Technical Field
The invention relates to the technical field of food or health food, in particular to a blood sugar reducing composition and a dietary supplement containing bitter gourd powder.
Background
In recent years, the Chinese social economy is rapidly developed, the living standard of people is obviously improved, and some 'rich diseases' are accompanied, typically, hyperlipidemia, atherosclerosis, diabetes and the like enter a high-incidence stage. Diabetes is an endocrine and metabolic disorder disease characterized by hyperglycemia, is accompanied by more complications such as heart disease, cerebral infarction and the like, and seriously endangers the body health of a patient. Because diabetes has the characteristics of long treatment period, difficult radical treatment, many complications and the like, besides the drug treatment, the auxiliary treatment of other diets has important significance for improving the condition of the diabetes or relieving the sub-health state.
Diabetes is caused by absolute or relative insufficiency of insulin, and is a disease mainly manifested by sugar metabolism disorder, and mainly manifested by fasting blood sugar and glycosylated hemoglobin rising. The diabetes patients are accompanied with immune reduction and chronic inflammation, such as the imbalance of T cell subset proportion and the increase of cytokines such as IL-6. Physiological and pathological changes in diabetics can lead to changes in the intestinal flora. It has been found that the diabetic patients have harmful bacteria in the intestinal flora while having elevated fasting glucose and glycated hemoglobin, and the bacteria in the family Enterobacteriaceae are elevated while the number of bifidobacteria is reduced. The structural imbalance of intestinal flora is a possible important mechanism for the occurrence of diabetes, and is particularly characterized in that the diversity and stability of the flora are destroyed, if beneficial flora is reduced or conditioned pathogenic flora is enhanced, the intestinal tract can be induced to generate low-grade chronic inflammation, and bacterial endotoxin is promoted to be released, so that insulin resistance is caused.
At present, there are many oral hypoglycemic drugs, and the clinical common varieties can be divided into 4 categories of insulin secretagogues, metabolic agents for promoting glucose in peripheral tissue cells, alpha-glucosidase inhibition for inhibiting glucose absorption by small intestine, and insulin sensitizers for improving insulin sensitivity and bioavailability according to functions or effects, specifically metformin, euglycemia, glycitin, repaglinide, nateglinide, medecan, and diligen, but the drugs taken for a long time are prone to have side effects such as dyspepsia, diarrhea, malnutrition, edema, liver and kidney injury. Therefore, the development of the blood sugar reducing composition which has small toxic and side effects and can be prepared into functional food is of great significance.
Disclosure of Invention
The first technical problem to be solved by the invention is as follows: a hypoglycemic composition with less toxic and side effects.
The second technical problem to be solved by the invention is: the application of the hypoglycemic composition is provided.
In order to solve the first technical problem, the invention adopts the technical scheme that: the composition capable of reducing blood sugar comprises the following raw materials in parts by weight:
Figure BDA0002202209070000021
preferably, the probiotics in the probiotic compound are all prepared by adopting a double-layer embedding microcapsule process.
Further, the probiotic compound is a mixture of bifidobacterium adolescentis, lactobacillus acidophilus and lactobacillus plantarum, and the mass ratio of the bifidobacterium adolescentis, the lactobacillus acidophilus and the lactobacillus plantarum is 2:2: 1.
Preferably, the particle size of all materials in the feedstock is below 15 μm.
Further, the balsam pear powder is prepared by a low-temperature water extraction method.
Preferably, the composition comprises the following raw materials in parts by weight:
Figure BDA0002202209070000022
Figure BDA0002202209070000031
furthermore, the composition may also contain white beech mushroom powder and scarlet caterpiller fungus powder.
Furthermore, the ratio of the white beech mushroom powder to the cordyceps militaris powder in parts by mass is (15-20) to (5-10).
Preferably, the mass ratio of the white beech mushroom powder to the cordyceps militaris bacterium powder is 2: 1.
Compared with the prior art, the invention has the beneficial effects that at least:
1. can effectively reduce blood sugar level. The invention utilizes the compounding among the raw materials to fully play a synergistic effect, and effectively reduces the blood sugar level by reducing/inhibiting the absorption of the body to glucose, improving the sensitivity of peripheral tissues to insulin, reducing the content of key enzyme in gluconeogenesis, increasing the content of key enzyme in pentose phosphate pathway and the like through the synergistic effect of multiple pathways.
2. Can reduce cholesterol. The formula is added with resistant dextrin and inulin which are both dietary fibers, and the dietary fibers can absorb the fat in the intestines to form a fat-fiber compound to be discharged along with the feces, thereby reducing the blood fat level. On the other hand, inulin is fermented by itself to short-chain fatty acids and lactate before the end of the intestinal tract, lactate is a regulator of liver metabolism, and propionate in the short-chain fatty acids can be used as fuel in blood, thereby inhibiting the synthesis of cholesterol.
3. Can effectively improve/prevent constipation. Firstly, the dietary fiber component and the plant fiber contained in the white beech mushroom powder added in the formula can promote the gastrointestinal peristalsis and enhance the excretion. Secondly, dietary fiber components are not digested and absorbed in the stomach and intestine, reducing the residence time of food in the stomach and intestine, increasing the amount of feces and promoting excretion. Finally, the combination of prebiotics and probiotics can inhibit the growth and metabolism of intestinal saprophytes to generate toxic metabolites, reduce the stimulation to the intestinal wall, improve the functions of intestines and stomach, enhance the digestion capability to food and ensure the smooth defecation.
4. Maintaining the balance of intestinal flora. The raw materials contain various plant polysaccharides to improve the intestinal flora structure and the intestinal microecology, so that the bifidobacteria in the intestinal tract can be proliferated to a certain extent, harmful bacteria can be inhibited, and the insulin resistance of the intestinal tract can be reduced.
5. It is effective in tonifying and strengthening body constitution. The raw materials contain various essential amino acids, various vitamins and rich mineral elements, and the product has effects of invigorating lung and kidney, tonifying body, and simultaneously, it also contains rich SOD enzyme, and the SOD enzyme and Bacillus bifidus cooperate to have good antioxidant effect.
6. Has small toxic and side effects and good safety. The raw materials in the composition are food-grade compounds, so that the composition has no side effect basically after long-term administration, and can not cause symptoms such as edema, liver and kidney injury and the like, and the probiotics can regulate intestinal microecological imbalance, promote digestion and absorption, and improve diarrhea, nutrient non-absorption and dyspepsia.
In order to solve the second technical problem, the invention adopts the technical scheme that: the composition capable of reducing blood sugar is applied to preparing foods or health-care products for preventing diabetes or assisting in reducing blood sugar.
Further, the application comprises the steps of:
s1, manually and uniformly mixing the probiotics in the probiotic compound for 0.5-2 min;
s2, manually mixing the probiotic compound treated by the operation with the momordica grosvenori powder and the okra powder uniformly for 0.5-2 min;
and S3, putting the bitter gourd powder, the isomaltitol, the resistant dextrin, the inulin and the okra powder into a three-dimensional mixer, and uniformly mixing for 15-40 min to obtain the food or the health-care product.
Compared with the prior art, the invention has the beneficial effects that at least: the preparation process of the scheme of the invention is simple, the preparation efficiency is high and the product stability is good; the raw materials with small proportion can be manually and initially mixed, then manually mixed with the raw materials with large proportion again, and finally mixed in a three-dimensional mixer, so that the mixing effect is good; compared with the traditional method of directly and synchronously mixing all materials, the method can shorten the mixing time (15-30) min and effectively improve the production efficiency; in addition, as the composition contains various probiotics and prebiotics, the growth of harmful microorganisms can be effectively inhibited or killed, the composition can be stably stored for a long time without sterilization or addition of a preservative, and simultaneously, the sensory, physicochemical and microbial indexes of the prepared product also meet the food safety requirements, so that the production process is simplified, the manufacturing cost is reduced, and the production efficiency is improved.
A dietary supplement for reducing blood sugar is prepared from raw materials containing the composition.
Further, the dietary supplement is in the form of powder, granules, compressed tablets, capsules or liquid.
Compared with the prior art, the invention has the beneficial effects that at least: the composition of the scheme of the invention can be prepared into the hypoglycemic product through simple processes such as mixing, sieving and the like, the dosage form can be prepared into various forms according to the needs, the composition can be directly mixed and prepared into solid powder, granules, tabletting or capsules, and the composition can also be mixed, sieved and dissolved to prepare liquid preparation, and the hypoglycemic product is convenient to eat.
Detailed Description
In order to explain the technical content, the objects and the effects of the present invention in detail, the following description will be given with reference to the embodiments.
The composition capable of reducing blood sugar comprises the following raw materials in parts by weight:
Figure BDA0002202209070000051
the bitter gourd powder is preferably prepared by low-temperature water extraction, has a molecular weight of 10000 daltons, and has a structure similar to insulin in a human body. The extract of Momordica charantia can inhibit glucose absorption, and inhibit Na-glucose transporter at small intestine epithelial brush border of rat to reduce glucose and liquid absorption in small intestine, wherein the inhibition is related to glucose concentration gradient, and the extract of Momordica charantia can inhibit Na on small intestine mucosal brush border+-K+The result of the pump; studies have shown that it is possible to inhibit the active transport of extracellular glucose, tyrosine and fluids in the small intestine, ultimately reducing their absorption, by inhibiting the sodium-glucose symporter. On the other hand, the balsam pear can play a role in reducing blood sugar by reducing the content of key enzyme in gluconeogenesis and increasing the content of key enzyme in pentose phosphate pathway.
The isomaltitol is used as a new food raw material, can improve the taste of the product, has slow hydrolysis speed and absorption speed, does not cause the fluctuation of blood sugar level and plasma insulin level, and does not cause the discomfort phenomena of abdominal distension, borborborygmus, diarrhea and the like even if the isomaltitol is eaten too much.
The resistant dextrin belongs to low molecular water-soluble dietary fiber, can delay and inhibit the digestion and absorption of small intestine to saccharides, improves the sensitivity of peripheral tissues to insulin, and reduces the demand of insulin. The water soluble resistant dextrin can prevent saccharide diffusion along with gel formation, delay saccharide absorption in intestine, and inhibit blood sugar rise and blood insulin rise after saccharide absorption. In addition, the resistant dextrin can change the secretion of digestive tract hormone, such as reducing the secretion of pancreatic juice, thereby inhibiting the absorption of saccharide. In addition, the resistant dextrin has the functions of inhibiting amylase from acting on starch, prolonging the time of the enzyme acting on the starch, and slowly releasing glucose, thereby playing the role of reducing blood sugar.
Inulin has the dual effects of dietary fiber and prebiotics, is substantially not decomposed and absorbed in oral cavity, stomach and small intestine, does not affect blood glucose level and insulin content in blood, and can produce propionate to inhibit gluconeogenesis, reduce free fatty acid level in blood plasma, and promote insulin resistance enhancement. Meanwhile, a large number of experiments prove that the inulin can reduce serum total cholesterol and low-density lipoprotein cholesterol, improve the ratio of high-density lipoprotein to low-density lipoprotein and improve the blood fat condition.
The momordica grosvenori is a natural sweetener which is 300 times sweeter than sucrose, but does not generate heat, is an ideal sweetener for people with diabetes, can well adjust the bitter taste of the momordica grosvenori, and enables the momordica grosvenori to have good taste.
The okra contains glycoprotein, active polysaccharide and polysaccharide protein, and the mixture of polysaccharide and protein mainly containing polysaccharide has good functional components for improving gastrointestinal dysfunction. The viscous glycoprotein contained in the okra powder can enhance the resistance of the body, protect the lubrication of the joint membrane and serosa in the joint cavity of the human body, keep the lubrication of the digestive tract and the respiratory tract of the human body, promote the excretion of cholesterol substances, reduce the deposition of lipid substances on the wall of an arterial tube, keep the elasticity of the arterial blood vessel, and prevent the occurrence of connective tissue atrophy and collagen diseases in the liver and the kidney; the okra can promote the excretion of organic substances in vivo, reduce the accumulation of toxins in vivo, reduce the contents of blood sugar and cholesterol, and simultaneously has the effects of promoting gastrointestinal motility and preventing constipation.
Preferably, the probiotics in the probiotic compound are all prepared by adopting a double-layer embedding microcapsule process.
Further, the probiotic compound is a mixture of bifidobacterium adolescentis, lactobacillus acidophilus and lactobacillus plantarum, and the mass ratio of the bifidobacterium adolescentis, the lactobacillus acidophilus and the lactobacillus plantarum is 2:2: 1.
Preferably, the particle size of all materials in the feedstock is below 15 μm.
The grain size of all materials in the raw materials is controlled to be 15 mu m, so that the mouthfeel is better.
Further, the balsam pear powder is prepared by a low-temperature water extraction method.
Preferably, the composition consists of the following raw materials in parts by weight:
furthermore, the composition may also contain white beech mushroom powder and scarlet caterpiller fungus powder.
The cordyceps militaris and the white beech mushroom are added, the secretion of insulin can be synergistically regulated, and the cordyceps militaris contains a large amount of cordyceps polysaccharide, so that the ingestion of glucose by insulin resistant fat cells can be promoted, the release of accumulated insulin can be promoted, the metabolism of insulin can be reduced, and the insulin level in serum can be improved; the magnesium rich in white beech mushroom and north cordyceps sinensis can also maintain the insulin secretion level of the blood sugar level of the organism and reduce the resistance of insulin, and the probiotic compound can promote the absorption and utilization of the magnesium and synergistically maintain the insulin secretion level of the organism.
The white beech mushroom contains effective components capable of enhancing T lymphocyte function, and can improve the capability of an organism for resisting various diseases, thereby promoting the healthy growth of a human body; in addition, the white beech mushroom is rich in polysaccharide and various vitamins, and can improve the metabolism of a human body and reduce the content of cholesterol; meanwhile, the dietary fiber contained in the white beech mushroom can promote gastrointestinal motility to keep the water balance in the intestines, absorb the residual cholesterol, cholate, triglyceride and sugar, discharge the cholesterol, cholate, triglyceride and sugar out of the body and reduce blood fat.
The cordyceps militaris is a fungus, contains cordycepin, cordycepic acid, polysaccharide and other components, has various effects of tonifying kidney, benefiting lung, building body and the like, can improve the immunity and blood circulation, and has various effects of calming nerves, resisting fatigue, improving sleep, reducing blood pressure, resisting inflammation, improving the body tolerance and the like. In addition, the scarlet caterpiller fungus also has antibacterial and SOD skin caring effects.
Furthermore, the ratio of the white beech mushroom powder to the cordyceps militaris powder in parts by mass is (15-20) to (5-10).
Preferably, the mass ratio of the white beech mushroom powder to the cordyceps militaris bacterium powder is 2: 1.
The invention also includes: the composition capable of reducing blood sugar is applied to preparing foods or health-care products for preventing diabetes or assisting in reducing blood sugar.
Further, the application comprises the steps of:
s1, manually and uniformly mixing the probiotics in the probiotic compound for 0.5-2 min;
s2, manually mixing the probiotic compound treated by the operation with the momordica grosvenori powder and the okra powder uniformly for 0.5-2 min;
and S3, putting the bitter gourd powder, the isomaltitol, the resistant dextrin, the inulin and the okra powder into a three-dimensional mixer, and uniformly mixing for 15-40 min to obtain the food or the health-care product.
A dietary supplement for reducing blood sugar is prepared from raw materials containing the composition.
Further, the dietary supplement is in the form of powder, granules, compressed tablets, capsules or liquid.
Compared with the prior art, the invention has the beneficial effects that at least: the composition of the scheme of the invention can be prepared into the hypoglycemic product through simple processes such as mixing, sieving and the like, the dosage form can be prepared into various forms according to the needs, can be directly mixed and prepared into solid powder, granules, tabletting or capsules, and can also be mixed, sieved and dissolved to prepare liquid preparation.
The first embodiment of the invention is as follows: a method of preparing a dietary nutritional supplement comprising the steps of:
taking 1 weight part of bifidobacterium adolescentis, 1 weight part of lactobacillus acidophilus and 0.5 weight part of lactobacillus plantarum, and manually mixing for 1 min; taking 5.25 parts by weight of momordica grosvenori powder, and manually mixing the mixed probiotics and the momordica grosvenori powder again; then 30 parts by weight of mountain balsam pear powder is taken; 20 parts by weight of isomalt; 22 parts of resistant dextrin; 20 parts of inulin; 3 parts of okra powder. All the materials are put into a V-shaped mixer to be mixed for 30min, and the rotating speed is 20 rpm/min; and filling the mixed materials into small bags by an automatic packaging machine, and then carrying out external packaging to obtain the solid beverage type product.
The second embodiment of the invention is as follows: a method of preparing a dietary nutritional supplement comprising the steps of:
taking 1.5 parts by weight of bifidobacterium adolescentis, 1.5 parts by weight of lactobacillus acidophilus and 0.75 part by weight of lactobacillus plantarum, and manually mixing for 1 min; taking 4.25 parts by weight of momordica grosvenori powder, and manually mixing the mixed probiotics and the momordica grosvenori powder again; taking 45 parts by weight of mountain balsam pear powder; 15 parts by weight of isomalt; 15 parts of resistant dextrin; 15 parts of inulin; and 4 parts of okra powder. All the materials are put into a V-shaped mixer to be mixed for 30min, and the rotating speed is 20 rpm/min; and filling the mixed materials into capsules by a capsule filling machine, and performing external packaging to obtain capsule products.
The third embodiment of the invention is as follows: a method of preparing a dietary nutritional supplement comprising the steps of:
taking 1.6 parts by weight of bifidobacterium adolescentis, 1.6 parts by weight of lactobacillus acidophilus and 0.8 part by weight of lactobacillus plantarum, and manually mixing for 1 min; taking 6 parts by weight of momordica grosvenori powder, and manually mixing the mixed probiotics and the momordica grosvenori powder again; then 25 parts by weight of mountain balsam pear powder is taken; 25 parts by weight of isomalt; 20 parts of resistant dextrin; 20 parts of inulin; 15 parts of white beech mushroom powder; 7.5 parts of cordyceps militaris bacterial powder; 3 parts of okra powder. All the materials are put into a V-shaped mixer to be mixed for 30min, and the rotating speed is 20 rpm/min; and granulating and packaging the mixed materials to obtain the granular product.
The first comparative example of the invention is as follows: a method for preparing a dietary nutritional supplement, which differs from the third embodiment only in that it does not comprise the step of adding probiotics.
The second comparative example of the present invention is: a method for preparing a dietary nutritional supplement, which only differs from the third embodiment in that the method does not comprise the step of adding balsam pear powder.
The third comparative example of the invention is: a method for preparing a dietary nutritional supplement, which differs from the third example only in that it does not comprise the step of adding inulin.
The fourth comparative example of the invention is: a method for preparing a dietary nutritional supplement, which is different from the third embodiment only in that the method does not comprise a step of adding okra powder.
The fifth comparative example of the present invention is: a method for preparing a dietary nutritional supplement, which is different from the third embodiment only in that the method does not comprise a step of adding momordica grosvenori powder.
The beneficial effects of the invention are proved by experimental detection and clinical tests.
1) Physicochemical and microbiological analysis
1 experimental method: the detection of the moisture content refers to GB 5009.3-2016, and the detection of the lead content refers to GB 5009.12-2017. Coliform bacteria detection refers to a GB 4789.3-2016 plate counting method, mould detection refers to GB 4789.15-2015, salmonella detection refers to GB 4789.4-2016, and staphylococcus aureus detection refers to GB 4789.10-2016 second method.
2 results of the experiment
The products prepared in the examples 1 to 3 and the comparative examples 1 to 5 have uniform tissue states, are uniform and light green, have soft bitter gourd powder smell, soft and moderate bitter taste and high acceptable degree; meanwhile, the indexes of water, lead, coliform bacteria, mould count, salmonella, staphylococcus aureus and the like all meet the national standard requirements.
2) Evaluation of hypoglycemic Effect
1 animal experiments for lowering blood sugar
400 mice after adaptive feeding (23 +/-2 ℃, and the illumination time is 12h/d) for one week are randomly divided into ten groups (the average weight of each group is 20 +/-2 g), all the groups are fasted for 10h overnight, after blood is taken for measuring fasting blood glucose, 20 mice are randomly used as healthy groups, other groups are injected with streptozotocin (80mg/ml) solution into the abdominal cavity of the mice, diabetic mice with the fasting blood glucose of (7-10) mmol/L are measured after 3 days, 280 diabetic mice are taken and randomly divided into a placebo group, a first control group, a second control group, a third control group, a fourth control group, a fifth control group, a first example group, a second example group and a third example group. Wherein, the healthy group is normally fed all the time, other groups except the normal feeding, the prepared dietary nutrients are respectively taken and added with water to prepare 2mg/ml solution for the first control group, the second control group, the third control group, the fourth control group, the fifth control group, the first example group, the second example group and the third example group, each mouse is subjected to intragastric administration once according to the volume/body weight ratio of 0.1ml/10g, the administration is continuously carried out for 12 days, and the placebo group is injected with water with the same amount. Fasting blood glucose was measured 4, 8, and 12 days after administration, respectively. The measurement results are shown in table 1 below:
TABLE 1
Figure BDA0002202209070000111
All fasting blood glucose measurements were taken after 10 hours overnight fast.
From the above table, it can be seen that the dietary nutritional supplement lacking probiotics, momordica grosvenori powder, momordica charantia powder, okra powder or inulin can reduce blood sugar to a certain extent, but the effect is far weaker than that of the example group, so that the scheme of the invention has different degrees of effects on reducing blood sugar among the raw materials, and the raw materials can obtain better blood sugar reduction effect through synergistic effect, and the blood sugar reduction effect after the components are combined is obviously improved; the blood sugar reducing effect of the control group without the probiotics is far weaker than that of other groups, which shows that the addition of the probiotics has great influence on the blood sugar reducing efficiency; the dietary supplement containing white beech mushroom powder and Cordyceps militaris powder has blood sugar lowering effect superior to that of the dietary supplement without white beech mushroom powder and Cordyceps militaris powder.
2 blood sugar lowering human body test eating test
30 patients (30-50 years old) with fasting blood glucose of more than 10mmol/L are randomly divided into three groups, each group respectively takes the dietary nutrition supplements prepared in the embodiment 1-3, 4g is taken every day, after taking for 20 days, the blood glucose is reduced by more than 35%, after taking for 2 months, the blood glucose is restored to within a normal level and feels energetic, meanwhile, the feelings of energetic are vigorous, indexes such as blood fat and cholesterol are obviously improved, and in addition, the complexion is better.
The probiotics in the embodiment are prepared by adopting a double-layer microcapsule embedding process, the activity is long, and the probiotics can be effectively planted.
The powder of Momordica charantia used in the above examples and comparative examples was a commercially available extract of Momordica charantia islets prepared by low temperature water extraction
Figure BDA0002202209070000121
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all equivalent modifications made by the present invention in the specification or directly or indirectly applied to the related technical field are included in the scope of the present invention.

Claims (10)

1. A composition capable of lowering blood glucose, comprising: the paint comprises the following components in parts by weight:
Figure FDA0002202209060000011
2. composition capable of lowering blood glucose according to claim 1, characterized in that: the probiotics in the probiotic compound are all prepared by adopting a double-layer embedding microcapsule process.
3. Composition capable of lowering blood glucose according to claim 1, characterized in that: the probiotic compound is a mixture of bifidobacterium adolescentis, lactobacillus acidophilus and lactobacillus plantarum, and the mass ratio of the bifidobacterium adolescentis to the lactobacillus acidophilus to the lactobacillus plantarum is 2:2: 1.
4. Composition capable of lowering blood glucose according to claim 1, characterized in that: the composition comprises the following components in parts by weight:
Figure FDA0002202209060000012
5. composition capable of lowering blood glucose according to claim 1, characterized in that: the composition may also contain white beech mushroom powder and scarlet caterpiller fungus powder.
6. Composition capable of lowering blood glucose according to claim 5, characterized in that: the mass ratio of the white beech mushroom powder to the cordyceps militaris powder is (15-20) to (5-10).
7. Use of the composition capable of reducing blood glucose according to any one of claims 1 to 6 in the preparation of a food or health product for preventing diabetes or assisting in reducing blood glucose.
8. Use according to claim 7, characterized in that: the method comprises the following steps:
s1, manually and uniformly mixing the probiotics in the probiotic compound for 0.5-2 min;
s2, manually mixing the probiotic compound treated by the operation with the momordica grosvenori powder and the okra powder uniformly for 0.5-2 min;
and S3, putting the bitter gourd powder, the isomaltitol, the resistant dextrin, the inulin and the okra powder into a three-dimensional mixer, and uniformly mixing for 15-40 min to obtain the food or the health-care product.
9. A hypoglycemic dietary supplement characterized by: the composition as claimed in any one of claims 1 to 6 is contained in the raw materials for the preparation of the dietary supplement.
10. The hypoglycemic dietary supplement of claim 9, wherein: the dietary supplement is in the form of powder, granules, compressed tablets, capsules or liquid.
CN201910869050.6A 2019-09-16 2019-09-16 Blood sugar lowering composition and dietary supplement containing bitter gourd powder Pending CN110710660A (en)

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CN112089054A (en) * 2020-09-22 2020-12-18 上海泓商生物科技有限公司 Blood sugar reducing probiotic composition
CN114304631A (en) * 2021-12-24 2022-04-12 湖南科尔生物技术有限公司 Blood glucose reducing nutritional supplement and preparation method and application thereof
CN115251388A (en) * 2022-08-09 2022-11-01 上海仁心善医健康科技有限公司 Composition for assisting in reducing blood sugar and food supplement thereof

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CN106666365A (en) * 2016-12-21 2017-05-17 孙中南 Powder and preparation method thereof
CN108112996A (en) * 2017-12-12 2018-06-05 法尔玛国际健康管理有限公司 A kind of alimentation composition for controlling diabetes B crowd hyperglycaemia and improving immunity
CN110192583A (en) * 2019-03-19 2019-09-03 上海迦林生物科技有限公司 With the composition and application for promoting intestinal health, control weight and raising to be immunized

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CN105725187A (en) * 2016-02-03 2016-07-06 上海普维健康食品有限公司 Blood sugar reducing composition and application in preparation of foods and health-care foods
CN106174585A (en) * 2016-06-30 2016-12-07 山东凤凰生物有限公司 Hypoglycemic compositions and hypoglycemic compound probiotic spy's dietary seafood
CN106666365A (en) * 2016-12-21 2017-05-17 孙中南 Powder and preparation method thereof
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112089054A (en) * 2020-09-22 2020-12-18 上海泓商生物科技有限公司 Blood sugar reducing probiotic composition
CN114304631A (en) * 2021-12-24 2022-04-12 湖南科尔生物技术有限公司 Blood glucose reducing nutritional supplement and preparation method and application thereof
CN115251388A (en) * 2022-08-09 2022-11-01 上海仁心善医健康科技有限公司 Composition for assisting in reducing blood sugar and food supplement thereof

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Application publication date: 20200121