CN104161874A - Compound traditional Chinese medicine composition for preventing and treating piglet bacillary dysentery and its preparation method and use - Google Patents
Compound traditional Chinese medicine composition for preventing and treating piglet bacillary dysentery and its preparation method and use Download PDFInfo
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Abstract
The invention discloses a compound traditional Chinese medicine composition for preventing and treating piglet bacillary dysentery and its preparation method and use, and belongs to the technical field of veterinary traditional Chinese medicines. The compound traditional Chinese medicine composition comprises, by weight, 6-15 parts of root of Chinese pulsatilla, 5-10 parts of flower of poplar, 5-15 parts of radix scutellariae and 5-10 parts of dandelion. Four pure natural Chinese herbal medicines do not cause resistance to drugs, have small toxic or side effect and do not easily produce harmful residue in the meat products. The active ingredients of the compound Chinese herbal medicines can be directly used for resisting bacteria, can stimulate or improve body specific and non-specific immunization functions, have wide-spectrum bacterium and virus resistance, and have substantial curative effects of preventing and treating piglet bacillary dysentery and especially preventing and treating piglet yellow and white scour. Through combination with fructo-oligosaccharide, the compound traditional Chinese medicine composition can improve body immunity, improve body gastrointestinal tract environment and adjust gastrointestinal tract flora balance.
Description
Technical field
The present invention is specifically related to a kind of for preventing and treating the herbal mixture compositions of piglet bacillary dysentery, and the preparation method and application of this Chinese medicine composition, belongs to Chinese medicine technical field for animals.
Background technology
Piglet causes that because antibacterial infects dysentery is very common, it comprises the baby swine paratyphoid being caused by Salmonella infection, the piglet pujos blancos, the yellow scours that are caused by coli-infection, infected piglet red dysentery causing etc. by C type clostridieum welchii, be cardinal symptom mainly with diarrhoea, fever and high mortality, in 20 ages in days, morbidity is more common.
Yellow and white dysentery of piglet is being collectively referred to as of yellow scour of piglet and piglet pujos blancos, and its M & M is all higher, is to cause piglet incubation motility rate low, affects one of principal disease of pig industry benefit.Yellow scour of piglet claims again early onset colibacillosis, mainly betides the piglet in a few hours to 7 ages in days after birth, this disease especially with the sickness rate of the first-born pig that sow pig is farrowed for the highest, the urgency of falling ill, mortality rate is also high.Piglet pujos blancos claims again Delayed onset colibacillosis, is caused by some serum of Escherichia coli, is a kind of acute infectious intestinal disease of 2-3 piglet in age in week, and sickness rate is higher.
Escherichia coli are very wide in distributed in nature, are also often present in the intestinal of pig, can not cause under normal circumstances morbidity.Bad when the feeding and management of piglet, pig house health is bad, sombrely moist, weather cataclysm, and the milk of sow is crossed rare or overrich, while causing piglet resistance to reduce, will cause a disease.From the escherichia coli that eject in sick pig body, its virulence strengthens, and when sodium selenite has been eaten the food that sick swine excrement pollutes, just can cause morbidity.When there being 1 dysentery in farrow, if take measures not in time, will propagate very soon.At present, clinical treatment is commonly used antibiotics, but because antibiotics easily produces drug resistance, and piglet gastrointestinal function is incomplete, and its therapeutic effect is unsatisfactory.If in cultivation there is bacillary dysentery in piglet, not only directly increase medicine and drop into, reduce efficiency of feed utilization, the cost that makes to raise pigs significantly rises, and has a strong impact on the incubation rate of piglet, threatens the health of piglet.Therefore, in Swine Production process, should keep a close eye on the control of doing bacillary dysentery well.
Summary of the invention
The object of this invention is to provide a kind of for preventing and treating the herbal mixture compositions of piglet bacillary dysentery.
Meanwhile, the present invention also provides a kind of for preventing and treating the preparation method of herbal mixture compositions of piglet bacillary dysentery.
Finally, the present invention also provides a kind of for preventing and treating the herbal mixture compositions of piglet bacillary dysentery as the application of feed additive.
In order to realize above object, the technical solution adopted in the present invention is:
For preventing and treating a herbal mixture compositions for piglet bacillary dysentery, mainly comprise the raw material of following weight portion: 6~15 parts of the Radix Pulsatillaes, 5~10 parts of flower of poplar, 5~15 parts of Radix Scutellariaes, 5~10 parts of Herba Taraxacis.
For preventing and treating a herbal mixture compositions for piglet bacillary dysentery, also comprise the raw material of following weight portion: 2~5 parts of oligofructose.
Preferably, a kind of for preventing and treating the herbal mixture compositions of piglet bacillary dysentery, comprise the raw material of following weight portion: 7~13 parts of the Radix Pulsatillaes, 6~7 parts of flower of poplar, 8~15 parts of Radix Scutellariaes, 6~9 parts of Herba Taraxacis, 2~5 parts of oligofructose.
More there is choosing, a kind of for preventing and treating the herbal mixture compositions of piglet bacillary dysentery, comprise the raw material of following weight portion: 10 parts of the Radix Pulsatillaes, 7 parts of flower of poplar, 15 parts of Radix Scutellariaes, 8 parts of Herba Taraxacis, 2 parts of oligofructose.
In the present invention, each raw material effect is summarized as follows:
The Radix Pulsatillae: be the root of the Ranunculaceae Pulsatilla plant Radix Pulsatillae; Contain triterpenoid as plurality of active ingredients such as Anemonin, betulic acid, 3-oxo fat acid, Pulsatilla saponin A, B, C, D; Nature and flavor hardship, cold, returns stomach, large intestine channel; Energy heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, removing dampness and killing parasites; Cure mainly dysentery, epistaxis, internal hemorrhoid with bleeding, cold and heat pyrexial malaria, scrofula, eczema carbuncle skin ulcer, eyes swelling pain etc.; Modern pharmacology proves that the Radix Pulsatillae has resisting pathogenic microbes, anti-ameba, anti-other pathogen, antitumor, antiinflammatory and strengthens the effects such as immunologic function.
Flower of poplar: for Salicaceae poplar Cortex Populi Tomentosae, eugene poplar or belong to the staminate inflorescence of several plants together; Nature and flavor hardship, cold; Energy heat-clearing and toxic substances removing, removing dampness dysentery relieving; Cure mainly bacillary dysentery, enteritis etc.
Radix Scutellariae: be the root of Labiatae Scutellaria plant Radix Scutellariae; Contain flavone compound as baicalin, skullcapflavone I, skullcapflavone II, baicalin, wogonin, chrysin etc., also contain the plurality of active ingredients such as cupreol, campesterol and stigmasterol; Radix Scutellariae nature and flavor hardship, cold; Return lung, the heart, liver, gallbladder, large intestine channel; Energy clearing away heat-fire, dampness removing toxic substances, hemostasis, antiabortive; Cure mainly cough due to lung-heat, calentura unconsciousness due to high fever, liver-fire headache, conjunctival congestion and swelling pain, jaundice due to damp-heat, dysentery, pyretic stranguria, tells nosebleed, metrorrhagia, excessive fetal movement due to heat in pregnancy, carbuncle furuncle etc.; Modern pharmacology proves that Radix Scutellariae has the effects such as antimicrobial, antioxidation, anticancer, blood pressure lowering, diuresis, blood fat reducing, protection ischemical reperfusion injury.
Herba Taraxaci: for Compositae Dandelion plant dandelion, alkali ground Herba Taraxaci, Herba Taraxaci ohwiani, different luxuriant Herba Taraxaci, Taraxacum asiatica Dahlst, Taraxacum erythropodium Kifag etc. belong to the herb of various plants together; Contain taraxasterol, choline, inulin, pectin, apigenin, rutin etc., also contain volatile oil as various active compositions such as hexanol, Camphora, n-octyl alcohols; Nature and flavor hardship, sweet, cold, return liver, stomach warp; Energy heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation; Cure mainly acute mastitis, lung abscess, acute appendicitis, mumps, scrofula, furuncle carbuncle toxin, conjunctival congestion and swelling pain, cold, fever, cough, laryngopharynx swelling and pain, gastritis, dysentery, hepatitis, cholecystitis, urinary tract infection, snake bite and insect sting, burn and scald etc.; Modern pharmacology proves that Herba Taraxaci has resisting pathogenic microbes, antiendotoxin, antitumor, anti-gastric-ulcer, function of gallbladder promoting, protects the liver and regulate the effects such as immunity.
Oligofructose: claim again oligofructose or fructooligosaccharide, be by 1~4 fructosyl by β-2,1 key is connected on the D-Fructose base of fructose and the ketose (GF forming
2), C24H42 O21 (GF
3), Fructofuranosyl nystose (GF
4) and sugarcane fruit six sugar (GF
5) mixture; Oligofructose is a kind of natural active matter, sugariness is sucrose 0.3~0.6 times, both kept the pure sweet taste character of sucrose, salubriouser than sucrose sweet taste again.
Oligofructose is except having the physicochemical properties of general utility functions oligosaccharide, also the tool physiological property of microbial population ratio in intestinal that has clear improvement.It is the activation and proliferation factor of enteral bacillus bifidus; can reduce and suppress the generation of enteral corrupt substance; to intestinal beneficial bacterium proliferation function as selective in bacillus bifidus, lactobacillus etc.; profitable strain is taken advantage in intestinal; suppress the growth of harmful bacteria, reduce noxious substance as the formation of endotoxin, Ammonia etc., intestinal mucosa cells regulating liver-QI is had to protective effect; can prevent the generation of pathological changes intestinal cancer, enhancing human body immunity power.Oligofructose can also promote absorption and the utilization of trace elements iron, calcium, to prevent osteoporosis; In addition, because oligofructose can not directly be digested and assimilated by human body, can only be absorbed by intestinal bacteria, therefore its calorific value is low, can not cause fat, indirectly also have antiobesity action; Because it can not be utilized by oral cavity bacterium (streptococcus mutans), thereby there is anticariogenic effect; Can lower the content of cholesterol in serum and triglyceride; Can reduce hepatotoxin, can in intestinal, generate anticancer organic acid, have significant preventing cancer function, can also prevent and treat diarrhoea and constipation; And pure taste, fragrant and sweet good to eat, has the adipose fragrance of class and tasty and refreshing soapy feeling.
For preventing and treating a herbal mixture compositions for piglet bacillary dysentery, can adopt conventional method to be prepared into the common dosage forms such as powder, granule, powder, solution, oral liquid.The present invention only provides a kind of preparation method of solution, comprises the following steps: accurately get the Radix Pulsatillae, flower of poplar, Radix Scutellariae and Herba Taraxaci according to weight portion, pulverize, sieve after oven dry, decoct with water again 3 times, add the water of 5~6 times of amounts at every turn, decoct 1~2 hour, filter merging filtrate and get final product.
Described bake out temperature is 60~80 DEG C.
Described sieves as crossing 100 mesh sieves.
For preventing and treating the preparation method of herbal mixture compositions for piglet bacillary dysentery, comprise the following steps:
(1) accurately get the Radix Pulsatillae, flower of poplar, Radix Scutellariae and Herba Taraxaci according to weight portion, pulverize, sieve after oven dry, then decoct with water 3 times, add the water of 5~6 times of amounts at every turn, decoct 1~2 hour, filter, merging filtrate is for subsequent use;
(2) in the filtrate of step (2), add oligofructose, stir evenly and get final product.
Described bake out temperature is 60~80 DEG C.
Described sieves as crossing 100 mesh sieves.
A kind of for preventing and treating the herbal mixture compositions of piglet bacillary dysentery as the application of feed additive, comprise the following steps: by weight percentage, the herbal mixture compositions for preventing and treating piglet bacillary dysentery is added to piglet drinking water with 0.05~0.1% amount.
Beneficial effect of the present invention:
The present invention adopts the Radix Pulsatillae, flower of poplar, Radix Scutellariae, Herba Taraxaci totally 4 taste pure natural Chinese herbal medicine, have little without Drug resistance, toxic and side effects, be difficult for producing the features such as hazard residue in meat, its effective ingredient except participate in directly antibacterial, can also excite or specificity and the non-specific immunity of enhancing body, there is antibacterial, the antivirus action of wide spectrum, control piglet bacillary dysentery especially yellow and white dysentery of piglet is had to significant curative effect.In addition, in Chinese herbal medicine, contained protein, saccharide, fat, starch, trace element, vitamin etc., can directly provide piglet body growth to grow required nutrient substance, can also reduce the irritability of domestic animal simultaneously, and drug effect gentleness.
The present invention is by above-mentioned 4 taste Chinese herbal medicine and oligofructose composition of prescription, and decapacitation improves outside immunity of organisms, can also improve body gastrointestinal tract environment, adjusts gastrointestinal bacterial flora balance, and promotion is digested and assimilated nutrient substance, and then is conducive to weightening finish and improves material anharmonic ratio.In addition, oligofructose can promote that in body intestinal lactobacillus, bacillus bifidus significantly increase, and suppresses pathogenic flora propagation, reduces the ill probability of piglet.
Aforementioned pharmaceutical compositions is prepared into solution by the present invention, and preparation method is simple, and easy operating is suitable for large-scale production and application.And solution is easy to use, have do not develop immunity to drugs, the feature such as toxic and side effects is little, noresidue.
Herbal mixture compositions of the present invention can replace antibiotics to add in piglet drinking-water, has the dual function of medicine and nutrition concurrently, can effectively prevent and treat the especially generation of yellow and white dysentery of piglet of piglet bacillary dysentery, reduces the irritability of domestic animal.
Detailed description of the invention
Following embodiment is only described in further detail the present invention, but does not form any limitation of the invention.
Embodiment 1
The raw material that comprises following weight portion for preventing and treating the Chinese medicine composition of piglet bacillary dysentery in the present embodiment: 6 parts of the Radix Pulsatillaes, 10 parts of flower of poplar, 5 parts of Radix Scutellariaes, 10 parts of Herba Taraxacis.
Preparation method for the Chinese medicine composition of preventing and treating piglet bacillary dysentery in the present embodiment comprises the following steps: accurately get the Radix Pulsatillae, flower of poplar, Radix Scutellariae and Herba Taraxaci according to weight portion, after drying, pulverize, cross 100 mesh sieves at 60 DEG C, decoct with water again 3 times, add the water of 5 times of amounts at every turn, decoct 1.5 hours, filter merging filtrate and get final product.
In the present embodiment for preventing and treating the Chinese medicine composition of piglet bacillary dysentery as the application of feed additive, comprise the following steps: by weight percentage, the Chinese medicine composition for preventing and treating piglet bacillary dysentery is added to piglet drinking water with 0.075% amount.
Embodiment 2
The raw material that comprises following weight portion for preventing and treating the Chinese medicine composition of piglet bacillary dysentery in the present embodiment: 15 parts of the Radix Pulsatillaes, 5 parts of flower of poplar, 15 parts of Radix Scutellariaes, 5 parts of Herba Taraxacis.
Preparation method for the Chinese medicine composition of preventing and treating piglet bacillary dysentery in the present embodiment comprises the following steps: accurately get the Radix Pulsatillae, flower of poplar, Radix Scutellariae and Herba Taraxaci according to weight portion, after drying, pulverize, cross 100 mesh sieves at 80 DEG C, decoct with water again 3 times, add the water of 6 times of amounts at every turn, decoct 2 hours, filter merging filtrate and get final product.
In the present embodiment for preventing and treating the Chinese medicine composition of piglet bacillary dysentery as the application of feed additive, comprise the following steps: by weight percentage, the Chinese medicine composition for preventing and treating piglet bacillary dysentery is added to piglet drinking water with 0.075% amount.
Embodiment 3
The raw material that comprises following weight portion for preventing and treating the herbal mixture compositions of piglet bacillary dysentery in the present embodiment: 6 parts of the Radix Pulsatillaes, 10 parts of flower of poplar, 5 parts of Radix Scutellariaes, 10 parts of Herba Taraxacis, 2 parts of oligofructose.
Preparation method for the Chinese medicine composition of preventing and treating piglet bacillary dysentery in the present embodiment comprises the following steps:
(1) accurately get the Radix Pulsatillae, flower of poplar, Radix Scutellariae and Herba Taraxaci according to weight portion, pulverize, cross 100 mesh sieves, then decoct with water 3 times after 60 DEG C of oven dry, add the water of 5 times of amounts at every turn, decoct 1.5 hours, filter, merging filtrate is for subsequent use;
(2) in the filtrate of step (2), add oligofructose, stir evenly and get final product.
In the present embodiment for preventing and treating the herbal mixture compositions of piglet bacillary dysentery as the application of feed additive, comprise the following steps: by weight percentage, the Chinese medicine composition for preventing and treating piglet bacillary dysentery is added to piglet drinking water with 0.075% amount.
Embodiment 4
The raw material that comprises following weight portion for preventing and treating the herbal mixture compositions of piglet bacillary dysentery in the present embodiment: 7 parts of the Radix Pulsatillaes, 6 parts of flower of poplar, 8 parts of Radix Scutellariaes, 9 parts of Herba Taraxacis, 3 parts of oligofructose.
Preparation method for the Chinese medicine composition of preventing and treating piglet bacillary dysentery in the present embodiment comprises the following steps:
(1) accurately get the Radix Pulsatillae, flower of poplar, Radix Scutellariae and Herba Taraxaci according to weight portion, pulverize, cross 100 mesh sieves, then decoct with water 3 times after 60 DEG C of oven dry, add the water of 6 times of amounts at every turn, decoct 2 hours, filter, merging filtrate is for subsequent use;
(2) in the filtrate of step (2), add oligofructose, stir evenly and get final product.
In the present embodiment for preventing and treating the herbal mixture compositions of piglet bacillary dysentery as the application of feed additive, comprise the following steps: by weight percentage, the Chinese medicine composition for preventing and treating piglet bacillary dysentery is added to piglet drinking water with 0.075% amount.
Embodiment 5
The raw material that comprises following weight portion for preventing and treating the herbal mixture compositions of piglet bacillary dysentery in the present embodiment: 10 parts of the Radix Pulsatillaes, 7 parts of flower of poplar, 15 parts of Radix Scutellariaes, 8 parts of Herba Taraxacis, 2 parts of oligofructose.
Preparation method for the Chinese medicine composition of preventing and treating piglet bacillary dysentery in the present embodiment comprises the following steps:
(1) accurately get the Radix Pulsatillae, flower of poplar, Radix Scutellariae and Herba Taraxaci according to weight portion, pulverize, cross 100 mesh sieves, then decoct with water 3 times after 80 DEG C of oven dry, add the water of 5 times of amounts at every turn, decoct 1 hour, filter, merging filtrate is for subsequent use;
(2) in the filtrate of step (2), add oligofructose, stir evenly and get final product.
In the present embodiment for preventing and treating the herbal mixture compositions of piglet bacillary dysentery as the application of feed additive, comprise the following steps: by weight percentage, the Chinese medicine composition for preventing and treating piglet bacillary dysentery is added to piglet drinking water with 0.075% amount.
Embodiment 6
The raw material that comprises following weight portion for preventing and treating the herbal mixture compositions of piglet bacillary dysentery in the present embodiment: 13 parts of the Radix Pulsatillaes, 7 parts of flower of poplar, 11 parts of Radix Scutellariaes, 6 parts of Herba Taraxacis, 5 parts of oligofructose.
Preparation method for the Chinese medicine composition of preventing and treating piglet bacillary dysentery in the present embodiment comprises the following steps:
(1) accurately get the Radix Pulsatillae, flower of poplar, Radix Scutellariae and Herba Taraxaci according to weight portion, pulverize, cross 100 mesh sieves, then decoct with water 3 times after 60 DEG C of oven dry, add the water of 5 times of amounts at every turn, decoct 1.5 hours, filter, merging filtrate is for subsequent use;
(2) in the filtrate of step (2), add oligofructose, stir evenly and get final product.
In the present embodiment for preventing and treating the herbal mixture compositions of piglet bacillary dysentery as the application of feed additive, comprise the following steps: by weight percentage, the Chinese medicine composition for preventing and treating piglet bacillary dysentery is added to piglet drinking water with 0.1% amount.
Test example
Experimental animal: choose at random 270 of certain plant 5 age in days piglets, be divided at random 9 groups, 30 every group.
Test group: feed the successively drinking water of interpolation solution of embodiment 1~7 preparation of test group 1~7, control group fed adds the drinking water of commercially available Chinese medicine (mixing medicine with 0.01%), the blank group conventional drinking water of feeding.
Test method: 240 5 age in days piglets are carried out to artificial counteracting toxic substances (Escherichia coli and Salmonella), the interpolation embodiment 1~7 that feeds successively according to dividing into groups after falling ill prepares the drinking water of solution, the drinking water that adds commercially available Chinese medicine and conventional drinking water, feed continuously at regular time and quantity 30 days, observe piglet clinical change record morbidity number, death toll and survival number every day, curative effect judging standard is as following, and result of the test refers to following table 1.
Curative effect judging standard:
Morbidity: in test, disease appears in piglet, as suffered from diarrhoea, drawing yellow, white loose stool, pig lethargy is depressed;
Dead: off-test piglet Mortality;
Survival: symptom appears in duration of test, it is as usual that off-test piglet recovers.
The each group result of the test of table 1
Conclusion: statistical analysis, in test group 1~7, the morbidity number of piglet and death toll are all significantly lower than matched group and blank group (P < 0.01), and survival rate is higher than 93%.
Claims (9)
1. for preventing and treating a herbal mixture compositions for piglet bacillary dysentery, it is characterized in that: the raw material that mainly comprises following weight portion: 6~15 parts of the Radix Pulsatillaes, 5~10 parts of flower of poplar, 5~15 parts of Radix Scutellariaes, 5~10 parts of Herba Taraxacis.
2. according to claim 1 for preventing and treating the herbal mixture compositions of piglet bacillary dysentery, it is characterized in that: the raw material that also comprises following weight portion: 2~5 parts of oligofructose.
3. according to claim 2 for preventing and treating the herbal mixture compositions of piglet bacillary dysentery, it is characterized in that: the raw material that comprises following weight portion: 7~13 parts of the Radix Pulsatillaes, 6~7 parts of flower of poplar, 8~15 parts of Radix Scutellariaes, 6~9 parts of Herba Taraxacis, 2~5 parts of oligofructose.
4. according to claim 3 for preventing and treating the herbal mixture compositions of piglet bacillary dysentery, it is characterized in that: the raw material that comprises following weight portion: 10 parts of the Radix Pulsatillaes, 7 parts of flower of poplar, 15 parts of Radix Scutellariaes, 8 parts of Herba Taraxacis, 2 parts of oligofructose.
One kind as claimed in claim 1 for preventing and treating the preparation method of herbal mixture compositions of piglet bacillary dysentery, it is characterized in that: comprise the following steps: accurately get the Radix Pulsatillae, flower of poplar, Radix Scutellariae and Herba Taraxaci according to weight portion, after oven dry, pulverize, sieve, decoct with water again 3 times, add the water of 5~6 times of amounts at every turn, decoct 1~2 hour, filter merging filtrate and get final product.
As described in claim 2-4 any one for preventing and treating the preparation method of herbal mixture compositions for piglet bacillary dysentery, it is characterized in that: comprise the following steps:
(1) accurately get the Radix Pulsatillae, flower of poplar, Radix Scutellariae and Herba Taraxaci according to weight portion, pulverize, sieve after oven dry, then decoct with water 3 times, add the water of 5~6 times of amounts at every turn, decoct 1~2 hour, filter, merging filtrate is for subsequent use;
(2) in the filtrate of step (2), add oligofructose, stir evenly and get final product.
7. according to claim 6 for preventing and treating the preparation method of herbal mixture compositions of piglet bacillary dysentery, it is characterized in that: described bake out temperature is 60~80 DEG C.
8. according to claim 6 for preventing and treating the preparation method of herbal mixture compositions of piglet bacillary dysentery, it is characterized in that: described sieves as crossing 100 mesh sieves.
One kind as described in claim 1-4 any one for preventing and treating the herbal mixture compositions of piglet bacillary dysentery as the application of feed additive, it is characterized in that: comprise the following steps: by weight percentage, the herbal mixture compositions for preventing and treating piglet bacillary dysentery is added to piglet drinking water with 0.05~0.1% amount.
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CN111714557A (en) * | 2020-08-10 | 2020-09-29 | 河北农业大学 | Traditional Chinese medicine composition for treating piglet diarrhea |
CN113069491A (en) * | 2021-04-21 | 2021-07-06 | 怀化职业技术学院 | Composition for preventing and treating pig digestive tract diseases and preparation method and application thereof |
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