CN103655301B - A kind of toothpaste containing Herba Achilleae extract and preparation method thereof - Google Patents
A kind of toothpaste containing Herba Achilleae extract and preparation method thereof Download PDFInfo
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- CN103655301B CN103655301B CN201310604998.1A CN201310604998A CN103655301B CN 103655301 B CN103655301 B CN 103655301B CN 201310604998 A CN201310604998 A CN 201310604998A CN 103655301 B CN103655301 B CN 103655301B
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- 239000000284 extract Substances 0.000 title claims abstract description 57
- 239000000606 toothpaste Substances 0.000 title claims abstract description 49
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 48
- 238000002360 preparation method Methods 0.000 title claims description 10
- 238000000605 extraction Methods 0.000 title description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 48
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 32
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 22
- 239000003765 sweetening agent Substances 0.000 claims abstract description 22
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims abstract description 16
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims abstract description 16
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 16
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 16
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims abstract description 16
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims abstract description 16
- 235000011187 glycerol Nutrition 0.000 claims abstract description 16
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims abstract description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 40
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 40
- 239000003292 glue Substances 0.000 claims description 36
- 239000007788 liquid Substances 0.000 claims description 26
- 230000002421 anti-septic effect Effects 0.000 claims description 20
- 239000008367 deionised water Substances 0.000 claims description 20
- 238000003756 stirring Methods 0.000 claims description 18
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 14
- 229910021641 deionized water Inorganic materials 0.000 claims description 14
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 14
- 239000003480 eluent Substances 0.000 claims description 14
- 238000010828 elution Methods 0.000 claims description 14
- 239000002994 raw material Substances 0.000 claims description 14
- 239000011347 resin Substances 0.000 claims description 14
- 229920005989 resin Polymers 0.000 claims description 14
- 239000000725 suspension Substances 0.000 claims description 12
- 239000003085 diluting agent Substances 0.000 claims description 8
- 238000001179 sorption measurement Methods 0.000 claims description 8
- 108010011485 Aspartame Proteins 0.000 claims description 6
- 235000006679 Mentha X verticillata Nutrition 0.000 claims description 6
- 235000002899 Mentha suaveolens Nutrition 0.000 claims description 6
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims description 6
- 239000000605 aspartame Substances 0.000 claims description 6
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical group OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 6
- 229960003438 aspartame Drugs 0.000 claims description 6
- 235000010357 aspartame Nutrition 0.000 claims description 6
- 235000013399 edible fruits Nutrition 0.000 claims description 6
- 239000000686 essence Substances 0.000 claims description 6
- 238000000227 grinding Methods 0.000 claims description 6
- 239000006072 paste Substances 0.000 claims description 6
- 238000011084 recovery Methods 0.000 claims description 6
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 6
- 235000010234 sodium benzoate Nutrition 0.000 claims description 6
- 239000004299 sodium benzoate Substances 0.000 claims description 6
- 241001122767 Theaceae Species 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 abstract description 10
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 8
- 241000700605 Viruses Species 0.000 abstract description 5
- 239000003814 drug Substances 0.000 abstract description 5
- 230000003266 anti-allergic effect Effects 0.000 abstract description 3
- 230000002804 anti-anaphylactic effect Effects 0.000 abstract description 3
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- 238000004140 cleaning Methods 0.000 abstract description 3
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- 238000005516 engineering process Methods 0.000 abstract description 3
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- 230000009286 beneficial effect Effects 0.000 abstract description 2
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- 235000003826 Artemisia Nutrition 0.000 description 1
- 235000003261 Artemisia vulgaris Nutrition 0.000 description 1
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- 244000030166 artemisia Species 0.000 description 1
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Abstract
The invention discloses a kind of toothpaste containing Herba Achilleae extract, described toothpaste is made up of Herba Achilleae extract, calcium carbonate, glycerol, sodium lauryl sulfate, carboxymethyl cellulose, sweetener and other auxiliary elements.Beneficial effect of the present invention is: the present invention is on the basis excavating uighur folk Traditional health care technology; utilize antibacterial, antiviral, antianaphylactic effect of Ethnic crude drugs and Chinese medicine; according to dimension medicine and Traditional Chinese medical theory; Herba Achilleae extract is equipped with other auxiliary elements; obtained a kind of can the toothpaste of antibacterial, antiviral, antiallergic, heat-clearing and toxic substances removing; life-time service; human body can be made to resist the ability enhancing of pathogenic bacteria, virus; prevent that illness finds its way in by the mouth, play the effect that cleaning oral cavity takes care of one's teeth.
Description
Technical field
The present invention relates to a kind of toothpaste and preparation method thereof, be specifically related to a kind of toothpaste containing Herba Achilleae extract and preparation method thereof.
Background technology
Herba Achilleae is Xinjiang characteristic Uygur medicine medicinal herbs most in use.The mountain region of growth about height above sea level 1000-3000 rice, herbaceos perennial, Herba Achilleae (ArtemisiarupestrisL.) is Compositae (Compostiae) artemisia (ArtemisiaL.) plant, Herba Achilleae contains the various active compositions such as flavonoid, Mek-Tol Unit, amino acids, glycoside, polysaccharide, sesquiterpenoids, volatile oil, polypeptide and alkaloid, has heat-clearing and toxic substances removing, antibacterial, antiviral effect.The proverb among the people that Xinjiang uighur ' s culture just spreads from ancient times " family have Herba Achilleae not to be afraid of stung by Serpentis, family has Herba Achilleae all kinds of diseases and ailments all to remove ".As everyone knows, toothpaste is necessary in human lives, although toothpaste kind is a lot, particularly in recent years, has emerged many Chinese herbal toothpastes, is all clean the teeth substantially or is main purpose toothpaste for solution oral inflammation.And in the prior art, Herba Achilleae extract is used for have not been reported in toothpaste.
Summary of the invention
Object of the present invention is exactly for above-mentioned defect of the prior art, provide a kind of toothpaste prepared for main component with the extract of Xinjiang distinctive uighur folk medical material Herba Achilleae, use this kind of toothpaste to brush teeth to play antibacterial, antiviral, antianaphylactic effect.
To achieve these goals, technical scheme provided by the invention is: a kind of toothpaste containing Herba Achilleae extract, and described toothpaste is made up of the component by following weight percent meter: calcium carbonate 45%-52%, glycerol 12%-15%, carboxymethyl cellulose 1%-2%, Herba Achilleae extract 8%-15%, sodium lauryl sulfate 2%-5%, essence 1%-1.5%, sweetener 0.2%-0.8%, antiseptic 1%-3%, calcium hydrogen phosphate 0.3%-0.5%, deionized water surplus.
Further, above-mentioned a kind of toothpaste containing Herba Achilleae extract, described toothpaste is made up of the component by following weight percent meter: calcium carbonate 50%, glycerol 13%, carboxymethyl cellulose 1.5%, Herba Achilleae extract 13%, sodium lauryl sulfate 4%, essence 1.2%, sweetener 0.5%, antiseptic 2%, calcium hydrogen phosphate 0.4%, deionized water surplus.
Further, above-mentioned a kind of toothpaste containing Herba Achilleae extract, described Herba Achilleae extract is diluted with water by the medicinal liquid that Herba Achilleae raw material obtains after twice decoction, and diluent with macroporous resin adsorption, then obtains to be concentrated by eluent after ethanol elution.
Further, above-mentioned a kind of toothpaste containing Herba Achilleae extract, described essence is one or more in Mint Essence, Herba Menthae Rotundifoliae essence, fruit essence, tea essence and medicated incense essence; Described sweetener is aspartame; Described antiseptic is sodium benzoate.
Second object of the present invention there is provided a kind of preparation method of the toothpaste containing Herba Achilleae extract, comprises the following steps:
1) get Herba Achilleae raw material to clean, first add 10 times of water to Herba Achilleae raw material volume and carry out first time and decoct, decocting time 2 hours after cutting, then to add water to the water yield be that 8 times of Herba Achilleae volume carry out second time decoction, decocting time 2 hours, obtains Herba Achilleae decoction liquor;
2) step 1) is obtained Herba Achilleae decoction liquor reject medicinal residues, treat that medicinal liquid is cooled to 60 DEG C, medicinal liquid and water are diluted with volume ratio 1:25, diluent obtains eluent with 70% ethanol elution with macroporous resin adsorption after 30 minutes again, the volumetric usage of ethanol is 10 times of resin volume, and elution flow rate is 3ml/min;
3) by step 2) eluent concentration and recovery ethanol below 60 DEG C of obtaining is 1.20 ~ 1.40 to relative density, namely obtains Herba Achilleae extract;
4) getting carboxymethyl cellulose according to above-mentioned ratio is added in glycerol, stirs and forms uniform suspension;
5) according to above-mentioned ratio, sweetener and calcium hydrogen phosphate are added in portions of de-ionized water, are stirred to and become transparent glue A;
6) deionized water of surplus is added in the suspension of step 4), stirs into transparent glue liquid B;
7) the transparent glue liquid B that transparent glue A step 5) obtained and step 6) obtain mixes, and obtains mixed glue solution;
8) calcium carbonate, essence, sodium lauryl sulfate, Herba Achilleae extract and antiseptic be added in the mixed glue solution that step 7) obtains according to above-mentioned ratio, stir into body of paste, then after colloidal grinding fill, namely become the toothpaste containing Herba Achilleae extract.
Beneficial effect of the present invention is: a kind of toothpaste containing Herba Achilleae extract provided by the invention, utilize Xinjiang ethnic groups medical material Herba Achilleae, obtain Herba Achilleae extract through techniques such as decoction, cooling, dilution, absorption, then combining with calcium carbonate, glycerol, sodium lauryl sulfate, carboxymethyl cellulose, sweetener and other auxiliary elements to obtain has antibacterial, antiviral, anti-allergic effects toothpaste.Herba Achilleae extract is used in toothpaste by the present invention can not only cleaning teeth, can also suppress virus, the growing of antibacterial very well, plays and takes care of one's teeth and the effect of health.
Current social, new virus is constantly being grown, and result in all kinds of infectious disease popular, thus the fast development of the medicine having driven antiviral to be correlated with and article of everyday use, especially the development of antiviral article of everyday use is very fast, and becoming a more ripe large class, is also develop a large class faster.The present invention overcomes the deficiency of existing market, technology, provides the toothpaste of a kind of energy antiviral, Anti-bacterium.Utilizing the distinctive uighur folk medical material in Xinjiang, through extracting, being applied in toothpaste.Herba Achilleae contains the various active compositions such as flavonoid, Mek-Tol Unit, amino acids, glycoside, polysaccharide, sesquiterpenoids, volatile oil, polypeptide and alkaloid, has antioxidation, antibacterial, antiviral, antianaphylactic effect.Using in the toothpaste process of brushing teeth, first making oral cavity cleaning, health, meanwhile, suppressing intraoral virus, the growing of pathogenic bacteria, reaching clean and the double effects of protection virus and pathogenic bacteria.This for Herba Achilleae antiviral, antibacterial, antiallergic medicinal plants are used for, in toothpaste, have not been reported, have wide market prospect.
Detailed description of the invention
embodiment 1:
A kind of toothpaste containing Herba Achilleae extract, be made up of the component by following weight percent meter: calcium carbonate 45%, glycerol 12%, carboxymethyl cellulose 1%, Herba Achilleae extract 8%, sodium lauryl sulfate 2%, essence 1%, sweetener 0.2%, antiseptic 1%, calcium hydrogen phosphate 0.3%, deionized water surplus.Essence is one or more in Mint Essence, Herba Menthae Rotundifoliae essence, fruit essence, tea essence and medicated incense essence; Sweetener is aspartame; Antiseptic is sodium benzoate.
The preparation method of the above-mentioned toothpaste containing Herba Achilleae extract, comprises the following steps:
1) get Herba Achilleae raw material to clean, first add 10 times of water to Herba Achilleae raw material volume and carry out first time and decoct, decocting time 2 hours after cutting, then to add water to the water yield be that 8 times of Herba Achilleae volume carry out second time decoction, decocting time 2 hours, obtains Herba Achilleae decoction liquor;
2) step 1) is obtained Herba Achilleae decoction liquor reject medicinal residues, treat that medicinal liquid is cooled to 60 DEG C, medicinal liquid and water are diluted with volume ratio 1:25, diluent obtains eluent with 70% ethanol elution with macroporous resin adsorption after 30 minutes again, the volumetric usage of ethanol is 10 times of resin volume, and elution flow rate is 3ml/min;
3) by step 2) eluent concentration and recovery ethanol below 60 DEG C of obtaining is 1.20 to relative density, namely obtains Herba Achilleae extract;
4) getting carboxymethyl cellulose according to above-mentioned ratio is added in glycerol, stirs and forms uniform suspension;
5) according to above-mentioned ratio, sweetener and calcium hydrogen phosphate are added in portions of de-ionized water, are stirred to and become transparent glue A;
6) deionized water of surplus is added in the suspension of step 4), stirs into transparent glue liquid B;
7) the transparent glue liquid B that transparent glue A step 5) obtained and step 6) obtain mixes, and obtains mixed glue solution;
8) calcium carbonate, essence, sodium lauryl sulfate, Herba Achilleae extract and antiseptic be added in the mixed glue solution that step 7) obtains according to above-mentioned ratio, stir into body of paste, then after colloidal grinding fill, namely become the toothpaste containing Herba Achilleae extract.
embodiment 2:
A kind of toothpaste containing Herba Achilleae extract, be made up of the component by following weight percent meter: calcium carbonate 48%, glycerol 12%, carboxymethyl cellulose 1%, Herba Achilleae extract 15%, sodium lauryl sulfate 2%, essence 1%, sweetener 0.3%, antiseptic 1.5%, calcium hydrogen phosphate 0.35%, deionized water surplus.Essence is one or more in Mint Essence, Herba Menthae Rotundifoliae essence, fruit essence, tea essence and medicated incense essence; Sweetener is aspartame; Antiseptic is sodium benzoate.
A preparation method for toothpaste containing Herba Achilleae extract, comprises the following steps:
1) get Herba Achilleae raw material to clean, first add 10 times of water to Herba Achilleae raw material volume and carry out first time and decoct, decocting time 2 hours after cutting, then to add water to the water yield be that 8 times of Herba Achilleae volume carry out second time decoction, decocting time 2 hours, obtains Herba Achilleae decoction liquor;
2) step 1) is obtained Herba Achilleae decoction liquor reject medicinal residues, treat that medicinal liquid is cooled to 60 DEG C, medicinal liquid and water are diluted with volume ratio 1:25, diluent obtains eluent with 70% ethanol elution with macroporous resin adsorption after 30 minutes again, the volumetric usage of ethanol is 10 times of resin volume, and elution flow rate is 3ml/min;
3) by step 2) eluent concentration and recovery ethanol below 60 DEG C of obtaining is 1.20 to relative density, namely obtains Herba Achilleae extract;
4) getting carboxymethyl cellulose according to above-mentioned ratio is added in glycerol, stirs and forms uniform suspension;
5) according to above-mentioned ratio, sweetener and calcium hydrogen phosphate are added in portions of de-ionized water, are stirred to and become transparent glue A;
6) deionized water of surplus is added in the suspension of step 4), stirs into transparent glue liquid B;
7) the transparent glue liquid B that transparent glue A step 5) obtained and step 6) obtain mixes, and obtains mixed glue solution;
8) calcium carbonate, essence, sodium lauryl sulfate, Herba Achilleae extract and antiseptic be added in the mixed glue solution that step 7) obtains according to above-mentioned ratio, stir into body of paste, then after colloidal grinding fill, namely become the toothpaste containing Herba Achilleae extract.
embodiment 3:
A kind of toothpaste containing Herba Achilleae extract, be made up of the component by following weight percent meter: calcium carbonate 50%, glycerol 13%, carboxymethyl cellulose 1.5%, Herba Achilleae extract 13%, sodium lauryl sulfate 4%, essence 1.2%, sweetener 0.5%, antiseptic 2%, calcium hydrogen phosphate 0.4%, deionized water surplus.Essence is one or more in Mint Essence, Herba Menthae Rotundifoliae essence, fruit essence, tea essence and medicated incense essence; Sweetener is aspartame; Antiseptic is sodium benzoate.
A preparation method for toothpaste containing Herba Achilleae extract, comprises the following steps:
1) get Herba Achilleae raw material to clean, first add 10 times of water to Herba Achilleae raw material volume and carry out first time and decoct, decocting time 2 hours after cutting, then to add water to the water yield be that 8 times of Herba Achilleae volume carry out second time decoction, decocting time 2 hours, obtains Herba Achilleae decoction liquor;
2) step 1) is obtained Herba Achilleae decoction liquor reject medicinal residues, treat that medicinal liquid is cooled to 60 DEG C, medicinal liquid and water are diluted with volume ratio 1:25, diluent obtains eluent with 70% ethanol elution with macroporous resin adsorption after 30 minutes again, the volumetric usage of ethanol is 10 times of resin volume, and elution flow rate is 3ml/min;
3) by step 2) eluent concentration and recovery ethanol below 60 DEG C of obtaining is 1.40 to relative density, namely obtains Herba Achilleae extract;
4) getting carboxymethyl cellulose according to above-mentioned ratio is added in glycerol, stirs and forms uniform suspension;
5) according to above-mentioned ratio, sweetener and calcium hydrogen phosphate are added in portions of de-ionized water, are stirred to and become transparent glue A;
6) deionized water of surplus is added in the suspension of step 4), stirs into transparent glue liquid B;
7) the transparent glue liquid B that transparent glue A step 5) obtained and step 6) obtain mixes, and obtains mixed glue solution;
8) calcium carbonate, essence, sodium lauryl sulfate, Herba Achilleae extract and antiseptic be added in the mixed glue solution that step 7) obtains according to above-mentioned ratio, stir into body of paste, then after colloidal grinding fill, namely become the toothpaste containing Herba Achilleae extract.
embodiment 4:
A kind of toothpaste containing Herba Achilleae extract, be made up of the component by following weight percent meter: calcium carbonate 52%, glycerol 15%, carboxymethyl cellulose 2%, Herba Achilleae extract 10%, sodium lauryl sulfate 5%, essence 1.5%, sweetener 0.8%, antiseptic 3%, calcium hydrogen phosphate 0.5%, deionized water surplus.Essence is one or more in Mint Essence, Herba Menthae Rotundifoliae essence, fruit essence, tea essence and medicated incense essence; Sweetener is aspartame; Antiseptic is sodium benzoate.
A preparation method for toothpaste containing Herba Achilleae extract, comprises the following steps:
1) get Herba Achilleae raw material to clean, first add 10 times of water to Herba Achilleae raw material volume and carry out first time and decoct, decocting time 2 hours after cutting, then to add water to the water yield be that 8 times of Herba Achilleae volume carry out second time decoction, decocting time 2 hours, obtains Herba Achilleae decoction liquor;
2) step 1) is obtained Herba Achilleae decoction liquor reject medicinal residues, treat that medicinal liquid is cooled to 60 DEG C, medicinal liquid and water are diluted with volume ratio 1:25, diluent obtains eluent with 70% ethanol elution with macroporous resin adsorption after 30 minutes again, the volumetric usage of ethanol is 10 times of resin volume, and elution flow rate is 3ml/min;
3) by step 2) eluent concentration and recovery ethanol below 60 DEG C of obtaining is 1.30 to relative density, namely obtains Herba Achilleae extract;
4) getting carboxymethyl cellulose according to above-mentioned ratio is added in glycerol, stirs and forms uniform suspension;
5) according to above-mentioned ratio, sweetener and calcium hydrogen phosphate are added in portions of de-ionized water, are stirred to and become transparent glue A;
6) deionized water of surplus is added in the suspension of step 4), stirs into transparent glue liquid B;
7) the transparent glue liquid B that transparent glue A step 5) obtained and step 6) obtain mixes, and obtains mixed glue solution;
8) calcium carbonate, essence, sodium lauryl sulfate, Herba Achilleae extract and antiseptic be added in the mixed glue solution that step 7) obtains according to above-mentioned ratio, stir into body of paste, then after colloidal grinding fill, namely become the toothpaste containing Herba Achilleae extract.
Last it is noted that the foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (5)
1. the toothpaste containing Herba Achilleae ArtemisiarupestrisL. extract, it is characterized in that, described toothpaste is made up of the component by following weight percent meter: calcium carbonate 45%-52%, glycerol 12%-15%, carboxymethyl cellulose 1%-2%, Herba Achilleae ArtemisiarupestrisL. extract 8%-15%, sodium lauryl sulfate 2%-5%, essence 1%-1.5%, sweetener 0.2%-0.8%, antiseptic 1%-3%, calcium hydrogen phosphate 0.3%-0.5%, deionized water surplus.
2. a kind of toothpaste containing Herba Achilleae ArtemisiarupestrisL. extract according to claim 1, it is characterized in that, described toothpaste is made up of the component by following weight percent meter: calcium carbonate 50%, glycerol 13%, carboxymethyl cellulose 1.5%, Herba Achilleae ArtemisiarupestrisL. extract 13%, sodium lauryl sulfate 4%, essence 1.2%, sweetener 0.5%, antiseptic 2%, calcium hydrogen phosphate 0.4%, deionized water surplus.
3. according to the arbitrary described a kind of toothpaste containing Herba Achilleae ArtemisiarupestrisL. extract of claim 1 or 2, it is characterized in that, described Herba Achilleae ArtemisiarupestrisL. extract is diluted with water by the medicinal liquid that Herba Achilleae ArtemisiarupestrisL. raw material obtains after twice decoction, diluent with macroporous resin adsorption, then obtains to be concentrated by eluent after ethanol elution.
4. according to the arbitrary described a kind of toothpaste containing Herba Achilleae ArtemisiarupestrisL. extract of claim 1 or 2, it is characterized in that, described essence is one or more in Mint Essence, Herba Menthae Rotundifoliae essence, fruit essence, tea essence and medicated incense essence; Described sweetener is aspartame; Described antiseptic is sodium benzoate.
5. a preparation method for the toothpaste containing Herba Achilleae ArtemisiarupestrisL. extract, is characterized in that, comprise the following steps:
1) get Herba Achilleae ArtemisiarupestrisL. raw material to clean, first add 10 times of water to Herba Achilleae ArtemisiarupestrisL. raw material volume after cutting and carry out first time decoction, decocting time 2 hours, adding water to the water yield is again that 8 times of Herba Achilleae ArtemisiarupestrisL. volume carry out second time and decoct, decocting time 2 hours, obtains Herba Achilleae ArtemisiarupestrisL. decoction liquor;
2) step 1) is obtained Herba Achilleae ArtemisiarupestrisL. decoction liquor reject medicinal residues, treat that medicinal liquid is cooled to 60 DEG C, medicinal liquid and water are diluted with volume ratio 1:25, diluent obtains eluent with 70% ethanol elution with macroporous resin adsorption after 30 minutes again, the volumetric usage of ethanol is 10 times of resin volume, and elution flow rate is 3ml/min;
3) by step 2) eluent concentration and recovery ethanol to relative density below 60 DEG C of obtaining is 1.20 ~ 1.40, namely obtains Herba Achilleae ArtemisiarupestrisL. extract;
4) getting carboxymethyl cellulose according to the ratio described in claim 1 or 2 is added in glycerol, stirs and forms uniform suspension;
5) according to the ratio described in claim 1 or 2, sweetener and calcium hydrogen phosphate are added in portions of de-ionized water, are stirred to and become transparent glue A;
6) deionized water of surplus is added in the suspension of step 4), stirs into transparent glue liquid B;
7) the transparent glue liquid B that transparent glue A step 5) obtained and step 6) obtain mixes, and obtains mixed glue solution;
8) calcium carbonate, essence, sodium lauryl sulfate, Herba Achilleae ArtemisiarupestrisL. extract and antiseptic be added in the mixed glue solution that step 7) obtains according to the ratio described in claim 1 or 2, stir into body of paste, again after colloidal grinding fill, namely become the toothpaste containing Herba Achilleae ArtemisiarupestrisL. extract.
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| CN105748356B (en) * | 2016-03-13 | 2019-09-10 | 新疆中草堂医药科技有限公司 | A kind of compound Artemisia rupestris bitter taste toothpaste |
| CN107303249A (en) * | 2016-04-20 | 2017-10-31 | 新疆中草堂医药科技有限公司 | A kind of compound lavender aromatic mouthwass |
| CN107303248A (en) * | 2016-04-20 | 2017-10-31 | 新疆中草堂医药科技有限公司 | A kind of compound Artemisia rupestris sterilizes gargle |
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| CN86100903A (en) * | 1986-01-03 | 1987-10-28 | 云南省东川市科学技术委员会 | Winter aconite tooth paste |
| CN1086432A (en) * | 1993-08-04 | 1994-05-11 | 中国中医研究院中药研究所 | Chinese medicine achillea millefolium preparation and preparation technology thereof |
| CN1306851A (en) * | 2000-01-28 | 2001-08-08 | 傅红喜 | Chinese medicine preparation for treating toothache |
| CN100593974C (en) * | 2006-08-24 | 2010-03-17 | 巴哈尔古丽·买合木提 | Wormwood tea |
| CN101712631A (en) * | 2008-10-08 | 2010-05-26 | 中国科学院新疆理化技术研究所 | Derivates of rupestonic acid and uses thereof |
| DE102009019104A1 (en) * | 2009-04-29 | 2010-11-04 | Bionorica Se | Cosmetic or dermatological composition containing hydrolysates from plant extracts |
| CN102040511A (en) * | 2010-09-27 | 2011-05-04 | 南京泽朗医药科技有限公司 | Method for preparing rupestonic aid |
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Effective date of registration: 20240411 Address after: Room 402, Unit 4, Building 1, No. 10 Xingfu South Road, Xinfu Road, Tianshan District, Urumqi, Xinjiang Uygur Autonomous Region, 830001 Patentee after: Li Na Country or region after: China Patentee after: Lei Hong Address before: Room 901, Chuangye Building, No. 682 Tianjin South Road, Xinshi District, Urumqi, Xinjiang Uygur Autonomous Region, 830011 Patentee before: URUMQI YIZHI-HAO BIOTECHNOLOGY Co.,Ltd. Country or region before: China |