CN106511185A - Toothpaste for preventing and treating gum bleeding and preparation method of toothpaste - Google Patents
Toothpaste for preventing and treating gum bleeding and preparation method of toothpaste Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention belongs to the technical field of daily use chemicals for oral cavity cleaning and particularly relates to toothpaste for preventing and treating gum bleeding and a preparation method of the toothpaste. The toothpaste mainly contains the following components in percentage by mass: 15%-20% of a friction agent, 10%-15% of glycerine, 2%-3% of sodium lauryl sulfate, 5%-8% of sodium alginate, 5%-8% of xylitol, 1%-2% of potassium citrate, 1%-2% of zinc citrate, 1%-2% of calcium lactate, 1%-2% of a subprostrate sophora alkaloid extract, 0.5%-1% of a rhubarb anthraquinone extract and 35%-55% of water. By using the toothpaste for a long time, gum bleeding can be well prevented, and furthermore, the oral cavity problems of ozostomia and the like can be solved.
Description
Technical field
The invention belongs to daily use chemicals oral cavity cleaning technical field, and in particular to the toothpaste and its system of a kind of preventing and treating gingival hemorrhage
Preparation Method.
Background technology
Gingival hemorrhage is a kind of common oral disease, and wherein main cause has the bacterial plaque on 1, facing clearly not do
Only, slowly calcification forms tartar at leisure, and long-time stimulates gingiva, causes gingiva telangiectasis, permeability to strengthen, cause
Various focusing depths represented, soft fragility, when outside mechanical irritation, gingiva is just easy to bleeding；2nd, pharyngolaryngitis, tonsillitiss etc. in oral cavity
Various focusing depths represented caused by inflammation, swell and ache etc. and to cause gingival hemorrhage.Therefore, it is desirable to solving gingival hemorrhage mainly treats oral inflammation
And remove oral cavity bacterium etc..
The toothpaste of early stage is primarily to cleaning action, appropriate addition wetting agent on the basis of abrasivuss and thickening agent
It is prepared from, but due to the attention of the multiple and people to oral health of oral problem, toothpaste is gradually from single component to many
The effects such as function development, such as addition antibacterial or the pre- anti-caries of anti-inflammation drugs, antiinflammatory, paroxysmal pain, but many compositions at present
Oral cavity bacterium can be made to develop immunity to drugs, therefore, select the active component of more health and safety particularly significant.
The Chinese patent application of Publication No. 103536482A discloses Caulis Sinomenii extract and Radix Sangusorbae extract and is preparing
Application in oral care product, i.e., by Caulis Sinomenii extract and Radix Sangusorbae extract with multiple in the technique for prepare oral care implement
Active component of the form of side as analgesia with preventing and treating gingival hemorrhage is added in oral care product, and the invention has significantly preventing and treating tooth
The effect of pain and gingival hemorrhage, but, the Chinese medicine extract of the disclosure of the invention mainly solve gingiva as approach to ease pain, stop blooding
Bleeding, can not tackle the problem at its root.
Notification number is that the Chinese patent of 102512349B discloses beneficial early benefit late Qing Dynasty fire combined tooth-paste, including abrasivuss, guarantor
Humectant, thickening agent, the medicinal herb componentses of anti-inflammation, zinc citrate and vinyl methyl ether/copolymer-maleic anhydride, morning shield
Reason, evening are consolidated, and can effectively suppress sooner or later the generation of dental plaque and dental calculuss using different toothpaste, fundamentally solve tooth
The cause of disease of Zhou Yan, can be effectively improved gingival hemorrhage, red swelling of gingiva and halitosiss problem.But, what the invention can not be well
The existing dirt in cleaning oral cavity, using rear clouding.
The content of the invention
In order to solve deficiency of the prior art, the invention discloses a kind of toothpaste of preventing and treating gingival hemorrhage and its preparation side
Method, the life-time service toothpaste have good preventing effectiveness, and can solve the oral problems such as halitosis to gingival hemorrhage.
Technical solution of the present invention is as follows.
A kind of toothpaste of preventing and treating gingival hemorrhage, mainly by following mass fraction into being grouped into：It is abrasivuss 15-20%, sweet
Oily 10-15%, sodium lauryl sulfate 2-3%, sodium alginate 5-8%, xylitol 5-8%, potassium citrate 1-2%, zinc citrate
1-2%, calcium lactate 1-2%, Radix Sophorae Tonkinensiss alkaloid extract 1-2%, Rhubarb extract 0.5-1% and water 35-55%.
Radix Sophorae Tonkinensiss have functions that heat-clearing and toxic substances removing, reducing swelling and alleviating pain, alkaloid component contained therein be main activity into
Point, there are good therapeutic effect, such as pharyngolaryngitis, tonsillitiss etc. to oral inflammation, the preventing and treating to oral inflammation can be prevented
It is further development of various focusing depths represented.
Radix Et Rhizoma Rhei is to toothache or oral suppurative imflammation has good anti-inflammatory analgesic effect, and its active component is mainly anthraquinone
Class compound.
The present invention also added potassium citrate, zinc citrate, calcium lactate active component, can effectively remove dental plaque,
Antiallergic effect, wherein calcium lactate not only can supplement dental surface calcium constituent, but also can improve other effective ingredient
Effect, and zinc citrate used cooperatively with Chinese medicine composition, can improve the inflammation-diminishing function of toothpaste.
Further, the toothpaste of described preventing and treating gingival hemorrhage, by following mass fraction into being grouped into：Abrasivuss
18%th, glycerol 13%, sodium lauryl sulfate 2.5%, sodium alginate 6.5%, xylitol 6.5%, potassium citrate 1.4%, Fructus Citri Limoniae
Sour zinc 1.5%, calcium lactate 1.6%, Radix Sophorae Tonkinensiss alkaloid extract 1.5%, Rhubarb extract 0.8% and water 46.7%.
Preferably, described abrasivuss are silicon dioxide.
Present invention also offers the extracting method of described Radix Sophorae Tonkinensiss alkaloid extract is：Radix Sophorae Tonkinensiss are immersed in into water
In, Radix Sophorae Tonkinensiss are 1g with the amount ratio of water:200-250ml, water temperature are 45-55 DEG C, are then adjusted using the sulphuric acid of 1.0mol/L
To 1.0-1.5, dipping was filtered, obtains filtrate after 6 hours pH value, then by filtering residue repeated impregnations 3 times, merging filtrate, and concentrating under reduced pressure
To the 1/10-1/20 of filtrate, be eventually adding saturated sodium carbonate and pH value adjusted to 8.5-9.0, obtain final product.
Further, the extracting method of described Rhubarb extract is：The extraction of described Rhubarb extract
Method is：By Radix Et Rhizoma Rhei crushed after being dried, then impregnate in ethanol, Radix Et Rhizoma Rhei is 1g with the amount ratio of ethanol solution:150-
Ethanol extract is filtered to obtain after 200ml, 8-12 hour, filtering residue repeated impregnations 2 times merge ethanol extract, are evaporated to filter
The 1/10-1/20 of liquid, obtains concentrated solution, then using the ether extraction 3 times of 10-15 times of quality of concentrated solution, each extraction time 4-6
Hour, merging ether extracted liquid, lyophilization is obtained final product.
Further, the invention discloses the preparation method of the toothpaste of described preventing and treating gingival hemorrhage, it is characterised in that step
Suddenly it is：
S1：By abrasivuss, glycerol, sodium lauryl sulfate, sodium alginate, xylitol, potassium citrate, zinc citrate, lactic acid
Calcium and water are added in colloid mill, are ground to 20-40 μm, discharging, obtain mixed liquor A；
S2：Mixed liquor A is put in homogenizer, 55-65 DEG C is heated to, Radix Sophorae Tonkinensiss alkaloid extract, big is subsequently adding
Yellow anthraquinones extract, stirs, homogeneous 15-25min, is cooled to room temperature, obtains final product.
Toothpaste active composition disclosed by the invention is Radix Sophorae Tonkinensiss alkaloid extract, Rhubarb extract and citric acid
Potassium, zinc citrate, calcium lactate components compatibility are used, and with good anti-plaque, antiinflammatory, prevent and treat effect of gingival hemorrhage.
Compared with prior art, the present invention has advantages below.
1st, safety：The present invention replaces traditional Chinese medicine ingredients, definite ingredients to reduce using Chinese herbal medicine activity extract
Side effect in use, safety are higher.
2nd, prevent and treat gingival hemorrhage：The present invention uses alkaloid and anthraquinones extract, with the use of potassium citrate, citric acid
Zinc, lactic acid calcium component, have functions that good antiinflammatory, analgesia and stop blooding.
Specific embodiment
In order that those skilled in the art become more apparent upon technical solution of the present invention, traveling one is entered by specific examples below
The explanation of step.
Embodiment 1
A kind of toothpaste of preventing and treating gingival hemorrhage, by following mass fraction into being grouped into：Silica 1 8%, glycerol
13%th, sodium lauryl sulfate 2.5%, sodium alginate 6.5%, xylitol 6.5%, potassium citrate 1.4%, zinc citrate 1.5%,
Calcium lactate 1.6%, Radix Sophorae Tonkinensiss alkaloid extract 1.5%, Rhubarb extract 0.8% and water 46.7%；
Wherein, the extracting method of described Radix Sophorae Tonkinensiss alkaloid extract is：Radix Sophorae Tonkinensiss are immersed in water, Radix Sophorae Tonkinensiss with
The amount ratio of water is 1g:230ml, water temperature are 50 DEG C, are then impregnated 6 hours to 1.3 using the sulfur acid for adjusting pH value of 1.0mol/L
Afterwards, filter, obtain filtrate, then by filtering residue repeated impregnations 3 times, merging filtrate is evaporated to the 1/15 of filtrate, is eventually adding full
PH value is adjusted to 8.8 with sodium carbonate, is obtained final product；
The extracting method of described Rhubarb extract is：By Radix Et Rhizoma Rhei crushed after being dried, then impregnate in ethanol, greatly
The yellow amount ratio with ethanol solution is 1g:180ml, filters to obtain ethanol extract after 10 hours, filtering residue repeated impregnations 2 times merge
Ethanol extract, is evaporated to the 1/15 of filtrate, obtains concentrated solution, then using the ether extraction 3 times of 13 times of quality of concentrated solution,
Every time 5 hours extraction times, merge ether extracted liquid, lyophilization is obtained final product.
The preparation method of the toothpaste of the preventing and treating gingival hemorrhage, step is：
S1：By abrasivuss, glycerol, sodium lauryl sulfate, sodium alginate, xylitol, potassium citrate, zinc citrate, lactic acid
Calcium and water are added in colloid mill, are ground to 30 μm, discharging, obtain mixed liquor A；
S2：Mixed liquor A is put in homogenizer, 60 DEG C are heated to, Radix Sophorae Tonkinensiss alkaloid extract, Radix Et Rhizoma Rhei anthracene is subsequently adding
Quinone extract, stirs, homogeneous 20min, is cooled to room temperature, obtains final product.
Embodiment 2
A kind of toothpaste of preventing and treating gingival hemorrhage, by following mass fraction into being grouped into：Silicon dioxide 20%, glycerol
10%th, sodium lauryl sulfate 3%, sodium alginate 5%, xylitol 8%, potassium citrate 1%, zinc citrate 2%, calcium lactate 1%,
Radix Sophorae Tonkinensiss alkaloid extract 2%, Rhubarb extract 0.5% and water 47.5%；
The extracting method of described Radix Sophorae Tonkinensiss alkaloid extract is similar to Example 1；
The extracting method of described Rhubarb extract is similar to Example 1.
The preparation method of the toothpaste of the preventing and treating gingival hemorrhage is similar to Example 1.
Embodiment 3
A kind of toothpaste of preventing and treating gingival hemorrhage, by following mass fraction into being grouped into：Silica 1 5%, glycerol
15%th, sodium lauryl sulfate 2%, sodium alginate 8%, xylitol 5%, potassium citrate 2%, zinc citrate 1%, calcium lactate 2%,
Radix Sophorae Tonkinensiss alkaloid extract 1%, Rhubarb extract 1% and water 48%；
The extracting method of described Radix Sophorae Tonkinensiss alkaloid extract is similar to Example 1；
The extracting method of described Rhubarb extract is similar to Example 1.
The preparation method of the toothpaste of the preventing and treating gingival hemorrhage is similar to Example 1.
Comparative example 1
A kind of toothpaste of preventing and treating gingival hemorrhage, by following mass fraction into being grouped into：Silica 1 8%, glycerol
13%th, sodium lauryl sulfate 2.5%, sodium alginate 6.5%, xylitol 6.5%, potassium citrate 1.4%, calcium lactate 1.6%, mountain
Radix Sophorae Tonkinensis alkaloid extract 1.5%, Rhubarb extract 2.3% and water 46.7%.
Compared with Example 1, difference is the content for increasing Rhubarb extract without zinc citrate；
The extracting method of described Radix Sophorae Tonkinensiss alkaloid extract is similar to Example 1；
The extracting method of described Rhubarb extract is similar to Example 1.
The preparation method of the toothpaste of the preventing and treating gingival hemorrhage is similar to Example 1.
Test example 1
Subjects：Embodiment 1-3 and the 1 obtained toothpaste for preventing and treating gingival hemorrhage of comparative example.
Test method：Obtained toothpaste is placed in dentifrice tube, pipe cap is coincide tightly, after 90 days, to toothpaste with the mouth of pipe
Quality is checked that concrete outcome is as shown in table 1.
The performance detection of 1 toothpaste of table
From table 1 it follows that toothpaste performance is more stable obtained in the present invention, after 90 days, the total plate count of mastic is
150-220CFU/g, less than national standard (≤500CFU/g)；Wherein mycete and yeast sum are 20-40CFU/g, meet state
Family's standard (≤100CFU/g), as the present invention is without preservative, but as the effective ingredient in the present invention has sterilization
Effect, therefore under rational compatibility, the sterilization and anticorrosion effect of the present invention meets national standard.But due in comparative example 1
Composition there occurs change, sterilization and anticorrosion effect also changes, and illustrates the reasonability of compatibility of the present invention, arbitrarily can not add
Subtract.
Treatment case
Wang, female 45 years old, cause gingiva to loosen bleeding due to not carrying out oral cavity cleaning work, and pain, daily gingiva go out
Blood number of times at 8-10 time, using toothpaste obtained in the embodiment of the present invention 1 30 days after, daily gingival hemorrhage number of times at 1-2 time, and
Toothache mitigates.
Cai, female, 25 years old, as pharyngolaryngitis, tonsillitiss further cause gingival hemorrhage, pain, daily gingival hemorrhage
Number of times at 4-5 time, using toothpaste obtained in the embodiment of the present invention 2 30 days after, daily gingival hemorrhage number of times at 0-1 time, and not
Have a toothache again.
Lee, man, 33 years old, due to do not note oral hygiene cause dental calculuss further cause gingiva loosen bleeding, pain,
Daily gingival hemorrhage number of times is at 5-6 time, using toothpaste obtained in the embodiment of the present invention 3 30 days after, daily gingival hemorrhage number of times exists
1-2 time, and no longer have a toothache.
In sum, toothpaste obtained in the present invention has the good effect for preventing gingival hemorrhage.
Claims (6)
1. a kind of toothpaste of preventing and treating gingival hemorrhage, it is characterised in that it is main by following mass fraction into being grouped into：Abrasivuss
15-20%, glycerol 10-15%, sodium lauryl sulfate 2-3%, sodium alginate 5-8%, xylitol 5-8%, potassium citrate 1-
2%th, zinc citrate 1-2%, calcium lactate 1-2%, Radix Sophorae Tonkinensiss alkaloid extract 1-2%, Rhubarb extract 0.5-1% and
Water 35-55%.
2. it is according to claim 1 preventing and treating gingival hemorrhage toothpaste, it is characterised in that by following mass fraction into packet
Into：Abrasivuss 18%, glycerol 13%, sodium lauryl sulfate 2.5%, sodium alginate 6.5%, xylitol 6.5%, potassium citrate
1.4%th, zinc citrate 1.5%, calcium lactate 1.6%, Radix Sophorae Tonkinensiss alkaloid extract 1.5%, 0.8% and of Rhubarb extract
Water 46.7%.
3. it is according to claim 1 and 2 preventing and treating gingival hemorrhage toothpaste, it is characterised in that described abrasivuss be dioxy
SiClx.
4. it is according to claim 1 and 2 preventing and treating gingival hemorrhage toothpaste, it is characterised in that described Radix Sophorae Tonkinensiss alkaloid
The extracting method of extract is：Radix Sophorae Tonkinensiss are immersed in water, Radix Sophorae Tonkinensiss are 1g with the amount ratio of water:200-250ml, water temperature is
45-55 DEG C, then using the sulfur acid for adjusting pH value of 1.0mol/L to 1.0-1.5, dipping was filtered, obtains filtrate, then after 6 hours
By filtering residue repeated impregnations 3 times, merging filtrate is evaporated to the 1/10-1/20 of filtrate, is eventually adding saturated sodium carbonate and adjusts pH
It is worth to 8.5-9.0, obtains final product.
5. the toothpaste of preventing and treating gingival hemorrhage according to claim 1 and 2, it is characterised in that described Radix Et Rhizoma Rhei anthraquinone is extracted
The extracting method of thing is：By Radix Et Rhizoma Rhei crushed after being dried, then impregnate in ethanol, Radix Et Rhizoma Rhei is 1g with the amount ratio of ethanol solution:
Ethanol extract is filtered to obtain after 150-200ml, 8-12 hour, filtering residue repeated impregnations 2 times merge ethanol extract, concentrating under reduced pressure
To the 1/10-1/20 of filtrate, concentrated solution is obtained, then using the ether extraction 3 times of 10-15 times of quality of concentrated solution, when extracting every time
Between 4-6 hours, merge ether extracted liquid, lyophilization obtains final product.
6. according to any one of claim 1-5 preventing and treating gingival hemorrhage toothpaste preparation method, it is characterised in that step
For：
S1：By abrasivuss, glycerol, sodium lauryl sulfate, sodium alginate, xylitol, potassium citrate, zinc citrate, calcium lactate and
Water is added in colloid mill, is ground to 20-40 μm, discharging, obtains mixed liquor A；
S2：Mixed liquor A is put in homogenizer, 55-65 DEG C is heated to, Radix Sophorae Tonkinensiss alkaloid extract, Radix Et Rhizoma Rhei anthracene is subsequently adding
Quinone extract, stirs, homogeneous 15-25min, is cooled to room temperature, obtains final product.
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Cited By (5)
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| CN109223637A (en) * | 2018-10-23 | 2019-01-18 | 缪剑华 | Subprostrate sophora herbal mixture toothpaste and preparation method |
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| CN109745263A (en) * | 2019-03-25 | 2019-05-14 | 广西壮族自治区药用植物园 | Subprostrate sophora pseudo-ginseng herbal mixture toothpaste and preparation method thereof |
| CN110507580A (en) * | 2019-09-20 | 2019-11-29 | 广东大鹏医药科技有限公司 | A kind of toothpaste of the ingredient containing trollflower and preparation method thereof |
| CN113116787A (en) * | 2021-05-17 | 2021-07-16 | 徐方文霄 | Formula and preparation method of rhubarb toothpaste |
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Cited By (7)
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| CN109223637A (en) * | 2018-10-23 | 2019-01-18 | 缪剑华 | Subprostrate sophora herbal mixture toothpaste and preparation method |
| CN109223637B (en) * | 2018-10-23 | 2021-05-11 | 缪剑华 | Compound traditional Chinese medicine subprostrate sophora toothpaste and preparation method thereof |
| CN109700723A (en) * | 2019-02-28 | 2019-05-03 | 青海民族大学 | A kind of antibacterial anti hemorrhagic dentifrice composition and preparation method thereof |
| CN109745263A (en) * | 2019-03-25 | 2019-05-14 | 广西壮族自治区药用植物园 | Subprostrate sophora pseudo-ginseng herbal mixture toothpaste and preparation method thereof |
| CN109745263B (en) * | 2019-03-25 | 2021-08-24 | 广西壮族自治区药用植物园 | Compound traditional Chinese medicine toothpaste containing subprostrate sophora and pseudo-ginseng and preparation method thereof |
| CN110507580A (en) * | 2019-09-20 | 2019-11-29 | 广东大鹏医药科技有限公司 | A kind of toothpaste of the ingredient containing trollflower and preparation method thereof |
| CN113116787A (en) * | 2021-05-17 | 2021-07-16 | 徐方文霄 | Formula and preparation method of rhubarb toothpaste |
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