CN109745263B - Compound traditional Chinese medicine toothpaste containing subprostrate sophora and pseudo-ginseng and preparation method thereof - Google Patents
Compound traditional Chinese medicine toothpaste containing subprostrate sophora and pseudo-ginseng and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a compound traditional Chinese medicine toothpaste containing subprostrate sophora and pseudo-ginseng, which comprises 0.05-2% of the subprostrate sophora and pseudo-ginseng composition by weight, wherein the subprostrate sophora and pseudo-ginseng composition is composed of pseudo-ginseng total saponins and subprostrate sophora alkaloid extract; and the preparation method of the compound traditional Chinese medicine toothpaste containing the subprostrate sophora and the pseudo-ginseng comprises the following steps: adding the radix Sophorae Tonkinensis and Notoginseng radix composition into toothpaste matrix, stirring and grinding for 30-60min, aging for 60-180min, naturally cooling to room temperature, and packaging. The subprostrate sophora and pseudo-ginseng compound traditional Chinese medicine toothpaste prepared by the invention has the advantages of high safety, good effects of sterilizing and treating periodontitis and the like.
Description
Technical Field
The invention relates to the field of traditional Chinese medicine toothpaste. More specifically, the invention relates to a compound traditional Chinese medicine toothpaste containing subprostrate sophora and pseudo-ginseng and a preparation method thereof.
Background
Vietnamese Sophora root (Latin name: Euchresta japonica), alias: radix Sophorae Tonkinensis, Leguminosae, and Sophora plant, has effects of clearing heat and detoxicating, eliminating swelling, relieving sore throat, and treating sore throat, gingival swelling and pain, and aphtha of mouth and tongue. The application of the subprostrate sophora root extract in the toothpaste has been reported in research, but because the matrine in the subprostrate sophora is both an effective component and a toxic component, how to maintain the effect of the subprostrate sophora root traditional Chinese medicine toothpaste on the basis of reducing the addition amount of the subprostrate sophora root extract so as to improve the safety of the subprostrate sophora root traditional Chinese medicine toothpaste is a problem which is urgently needed to be solved in the application field of the subprostrate sophora root in the toothpaste.
Disclosure of Invention
The invention aims to provide a subprostrate sophora and panax notoginseng compound traditional Chinese medicine toothpaste, which is prepared by compounding subprostrate sophora alkaloid extract and panax notoginseng saponins, and by utilizing the synergistic interaction of the subprostrate sophora and panax notoginseng saponins, the addition amount of the subprostrate sophora alkaloid extract is obviously reduced while the efficacy of the subprostrate sophora traditional Chinese medicine toothpaste is ensured, and the safety is high.
In order to achieve the objects and other advantages, the invention provides a subprostrate sophora and pseudo-ginseng compound traditional Chinese medicine toothpaste, which comprises 0.05-2% of subprostrate sophora and pseudo-ginseng composition by weight, wherein the subprostrate sophora and pseudo-ginseng composition is total saponins of pseudo-ginseng and extracts of subprostrate sophora and pseudo-ginseng alkaloid.
Preferably, the subprostrate sophora and pseudo-ginseng compound traditional Chinese medicine toothpaste is characterized in that the subprostrate sophora and pseudo-ginseng composition accounts for 0.1-1% of the weight of the subprostrate sophora and pseudo-ginseng compound traditional Chinese medicine toothpaste.
Preferably, the compound traditional Chinese medicine toothpaste containing the subprostrate sophora and the pseudo-ginseng and the preparation method thereof are characterized in that the weight percentage of the subprostrate sophora and the pseudo-ginseng composition in the compound traditional Chinese medicine toothpaste containing the subprostrate sophora and the pseudo-ginseng is 0.15-0.6%.
Preferably, in the subprostrate sophora and panax notoginseng compound traditional Chinese medicine toothpaste, the weight ratio of the panax notoginseng saponins to the subprostrate sophora alkaloid extract is 1: 1-10.
Preferably, the preparation method of the subprostrate sophora root and pseudo-ginseng compound traditional Chinese medicine toothpaste comprises the following steps: adding 7-10 times of water by weight into dried radix Sophorae Tonkinensis medicinal material, reflux-extracting at 98 + -2 deg.C for two times (2 hr each time), filtering, mixing filtrates, and concentrating the filtrate to obtain extract; dissolving the obtained extract with 2-3 weight times of 20-30% ethanol, filtering, adding the obtained filtrate into macroporous resin, eluting with water for 3 column volumes, collecting 2 nd and 3 rd column volumes of water, mixing, and concentrating to obtain extract.
Preferably, the compound traditional Chinese medicine toothpaste containing subprostrate sophora and pseudo-ginseng also comprises a toothpaste matrix, wherein the toothpaste matrix comprises the following raw materials in parts by weight: 30-40 parts of calcium carbonate, 5-15 parts of sorbitol, 1-10 parts of hydrated silica, 4-8 parts of glycerol, 80.3-1 parts of polyethylene glycol, 1-3 parts of sodium lauryl sulfate, 1-3 parts of essence, 1-2 parts of cellulose gum, 0.05-0.1 part of panax notoginseng saponins, 0.1-0.5 part of subprostrate sophora alkaloid extract, 0.1-0.3 part of tranexamic acid, 0.5-1 part of carrageen crispus, 0.5-1 part of saccharin sodium, 0.1-0.5 part of methylparaben, 0.1-0.5 part of propylparaben and 0.02-0.04 part of bis (hydroxymethyl) imidazolidinyl urea, wherein the calcium carbonate has physical detergency and can clean and whiten teeth and prevent dental calculus from deposition by matching with a correct tooth brushing mode; tranexamic acid can effectively relieve and prevent gingival bleeding, oral bleeding and the like, has better whitening effect, and has the effects of blackening and removing spots which are about 50 times higher than that of vitamin C and about 10 times higher than that of tartaric acid; the bis-hydroxymethyl imidazolidinyl urea can inhibit the propagation of microorganisms, has an antibacterial effect on gram-positive bacteria and gram-negative bacteria including pseudomonas and selectively inhibits yeasts and molds; the essence can be mint type, orchid type, wintergreen type, fruit type, tea type, etc., preferably mint type, to refresh breath, and improve nausea caused by brushing teeth of some pharyngolaryngitis patients by using the unique cool and throat-moistening and fragrant smell of mint.
A preparation method of compound traditional Chinese medicine toothpaste containing subprostrate sophora and pseudo-ginseng comprises the following steps: adding the radix sophorae tonkinensis and radix notoginseng composition into a toothpaste matrix, stirring and grinding for 30-60min, aging for 60-180min, naturally cooling the materials to normal temperature, and subpackaging to obtain the compound traditional Chinese medicine toothpaste, wherein the radix sophorae tonkinensis and radix notoginseng composition accounts for 0.05-5% of the weight of the compound traditional Chinese medicine toothpaste, and the radix sophorae tonkinensis and radix notoginseng composition consists of total saponins of radix sophorae tonkinensis and alkaloid extracts of radix sophorae tonkinensis in a weight ratio of 1: 1-10.
Preferably, the preparation method of the subprostrate sophora root and pseudo-ginseng compound traditional Chinese medicine toothpaste comprises the following steps: adding 7-10 times of water by weight into dried radix Sophorae Tonkinensis medicinal material, reflux-extracting at 98 + -2 deg.C for two times (2 hr each time), filtering, mixing filtrates, and concentrating the filtrate to obtain extract; dissolving the obtained extract with 2-3 weight times of 20-30% ethanol, filtering, adding the obtained filtrate into macroporous resin, eluting with water for 3 column volumes, collecting 2 nd and 3 rd column volumes of water, mixing, and concentrating to obtain extract.
Preferably, the preparation method of the compound traditional Chinese medicine toothpaste containing the subprostrate sophora and the pseudo-ginseng comprises the following raw materials in parts by weight: 30-40 parts of calcium carbonate, 5-15 parts of sorbitol, 1-10 parts of hydrated silica, 4-8 parts of glycerol, 80.3-1 parts of polyethylene glycol, 1-3 parts of sodium lauryl sulfate, 1-3 parts of essence, 1-2 parts of cellulose gum, 0.05-0.1 part of panax notoginseng saponins, 0.1-0.5 part of subprostrate sophora alkaloid extract, 0.1-0.3 part of tranexamic acid, 0.5-1 part of carrageen crispus, 0.5-1 part of saccharin sodium, 0.1-0.5 part of methylparaben, 0.1-0.5 part of propylhydroxybenzoate and 0.02-0.04 part of bis-hydroxymethyl imidazolidinyl urea.
Preferably, the preparation method of the compound traditional Chinese medicine toothpaste containing the subprostrate sophora and the pseudo-ginseng further comprises the step of vacuumizing in the stirring and grinding process, wherein the vacuum pressure is-0.096 MPa.
The invention at least comprises the following beneficial effects:
firstly, the subprostrate sophora root alkaloid extract and the panax notoginseng saponins are compounded, and the synergistic effect of the two is utilized, so that the addition amount of the subprostrate sophora root alkaloid extract is obviously reduced while the efficacy of the subprostrate sophora root traditional Chinese medicine toothpaste is ensured, and the safety is high;
secondly, the toothpaste can help to relieve gum swelling and pain, inhibit harmful bacteria from breeding, control and maintain the ecological balance of oral flora, prevent and treat periodontitis and oral ulcer, and is more safe and effective because the mouth and teeth feel comfortable after the toothpaste is used.
Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention.
Detailed Description
The present invention is further described in detail below with reference to examples so that those skilled in the art can practice the invention with reference to the description.
It is to be noted that the experimental procedures described in the following examples are conventional ones unless otherwise specified, and the reagents and materials described therein are commercially available without otherwise specified.
Example 1
Preparing the subprostrate sophora alkaloid extract: adding 1700kg of water into 200kg of dried radix Sophorae Tonkinensis medicinal material, extracting under reflux at 98 + -2 deg.C for 2 hr twice, filtering, mixing filtrates, and concentrating at 60 deg.C to obtain extract; dissolving the obtained extract with 2.5 weight times of 20-30% ethanol, filtering, adding the filtrate into macroporous resin (model: D101), eluting with water for 3 column volumes, collecting 2 nd and 3 rd column volumes of water, mixing, and concentrating at 60 deg.C to obtain extract.
Preparing the panax notoginseng saponins: adding 700L of 80 vol% ethanol into 100kg of radix Notoginseng coarse powder, reflux-extracting at 80 deg.C twice, each for 2 hr, filtering, mixing filtrates, fine-filtering with membrane separation system, collecting filtrate, and concentrating at 60 deg.C to obtain extract.
Example 2
Taking 1.0g of the total saponins of panax notoginseng prepared in the example 1, 1.0g of subprostrate sophora alkaloid extract, 30g of calcium carbonate, 15g of sorbitol, 10g of hydrated silica, 4g of glycerol, 81g of polyethylene glycol, 3g of sodium lauryl sulfate, 2g of wintergreen essence, 2g of cellulose gum, 0.3g of tranexamic acid, 1g of crinkle carrageenan, 0.5g of saccharin sodium, 0.5g of methyl hydroxybenzoate, 0.1g of propyl hydroxybenzoate and 0.04g of bis (hydroxymethyl) imidazolidinyl urea, adding the rest deionized water to 100g of the traditional Chinese medicine toothpaste by weight of 100g, stirring and grinding for 60min, vacuumizing (the pressure is-0.096 MPa) in the stirring and grinding process, aging for 180min, and subpackaging after the materials are naturally cooled to normal temperature to obtain the compound traditional Chinese medicine toothpaste of the subprostrate sophora and the panax notoginseng.
Example 3
Taking 0.2g of the panax notoginseng saponins prepared in the example 1, 0.8g of subprostrate sophora alkaloid extract, 40g of calcium carbonate, 10g of sorbitol, 10g of hydrated silica, 4g of glycerol, 81g of polyethylene glycol, 3g of sodium lauryl sulfate, 1g of blueberry essence, 1g of cellulose gum, 0.3g of tranexamic acid, 1g of crinkle carrageenan, 1g of saccharin sodium, 0.1g of methyl hydroxybenzoate, 0.1g of propyl hydroxybenzoate and 0.02g of bis-hydroxymethyl imidazolidinyl urea, adding the rest deionized water to 100g of the traditional Chinese medicine toothpaste based on 100g by weight, stirring and grinding for 30min, vacuumizing (the pressure is-0.096 MPa) in the stirring and grinding process, aging for 60min, and subpackaging after the materials are naturally cooled to the normal temperature to obtain the compound traditional Chinese medicine toothpaste of the subprostrate sophora notoginseng.
Example 4
Taking 0.08g of panax notoginseng saponins prepared in example 1, 0.25g of subprostrate sophora alkaloid extract, 35g of calcium carbonate, 10g of sorbitol, 5g of hydrated silica, 6g of glycerol, 80.5 g of polyethylene glycol, 2g of sodium lauryl sulfate, 2g of spearmint essence, 1.5g of cellulose gum, 0.2g of tranexamic acid, 0.8g of carrageen crispus, 0.8g of saccharin sodium, 0.3g of methyl hydroxybenzoate, 0.3g of propyl hydroxybenzoate and 0.03g of bis (hydroxymethyl) imidazolidinyl urea, adding the rest deionized water to 100g of the traditional Chinese medicine toothpaste by weight, stirring and grinding for 45min, vacuumizing (the pressure is-0.096 MPa) in the stirring and grinding process, and finally, carrying out 120min, and carrying out split charging and aging after the materials are naturally cooled to normal temperature, thereby obtaining the compound traditional Chinese medicine toothpaste containing subprostrate sophora and panax notoginseng.
Example 5
Taking 0.05g of the panax notoginseng saponins prepared in the example 1, 0.1g of subprostrate sophora alkaloid extract, 30g of calcium carbonate, 15g of sorbitol, 10g of hydrated silica, 8g of glycerol, 80.3 g of polyethylene glycol, 1g of sodium lauryl sulfate, 3g of essence, 2g of cellulose gum, 0.1g of tranexamic acid, 0.5g of carrageen crispus, 0.5g of saccharin sodium, 0.1g of methyl hydroxybenzoate, 0.1g of propyl hydroxybenzoate and 0.02g of bis (hydroxymethyl) imidazolidinyl urea, adding the rest of deionized water to 100g of the traditional Chinese medicine toothpaste by weight, stirring and grinding for 45min, vacuumizing (the pressure is-0.096 MPa) in the stirring process, aging for 80min, naturally cooling the materials to the normal temperature, and subpackaging to obtain the compound traditional Chinese medicine toothpaste 1 of the subprostrate sophora and the panax notoginseng.
Example 6
Taking 0.1g of the panax notoginseng saponins prepared in the example 1, 0.5g of subprostrate sophora alkaloid extract, 40g of calcium carbonate, 15g of sorbitol, 10g of hydrated silica, 8g of glycerol, 80.3 g of polyethylene glycol, 1g of sodium lauryl sulfate, 3g of essence, 2g of cellulose gum, 0.1g of tranexamic acid, 0.5g of carrageen crispus, 0.5g of saccharin sodium, 0.5g of methyl hydroxybenzoate, 0.5g of propyl hydroxybenzoate and 0.04g of bis (hydroxymethyl) imidazolidinyl urea, adding the rest deionized water to 100g of the traditional Chinese medicine toothpaste by weight, stirring and grinding for 60min, vacuumizing (the pressure is-0.096 MPa) in the stirring process, aging for 150min, naturally cooling the materials to the normal temperature, and subpackaging to obtain the panax notoginseng compound traditional Chinese medicine toothpaste 2.
Comparative example 1
Comparative example 1 is substantially the same as example 6 except that only panax notoginseng saponins are added, the subprostrate sophora alkaloid extract is not added, and the addition amount of the panax notoginseng saponins is 0.6g, so that the traditional Chinese medicine toothpaste D1 is obtained.
Comparative example 2
Comparative example 2 is substantially the same as example 6 except that only the subprostrate sophora alkaloid extract is added, the panax notoginseng saponins are not added, and the addition amount of the subprostrate sophora alkaloid extract is 0.6g, so as to obtain the traditional Chinese medicine toothpaste D2.
Comparative example 3
Comparative example 3 is substantially the same as example 6 except that the total saponins of panax notoginseng and the alkaloid extract of subprostrate sophora are replaced with deionized water to obtain blank toothpaste K1.
Experimental example 1
The subprostrate sophora and pseudo-ginseng compound traditional Chinese medicine toothpaste prepared in the embodiments 5 and 6 of the invention and the toothpaste prepared in the comparative examples 1-3 are subjected to a bactericidal effect test, and the test method comprises the following steps: mixing (9-10). times.104The bacterial solution of cfu/g was uniformly spread on the plate, and then toothpaste was uniformly spread on the surface of the plate, and the plate was incubated for 10 minutes, and the number of viable bacteria (in cfu/g) on the plate was measured, and the number of viable bacteria was compared with the number of bacteria in the original bacterial solution to obtain the antibacterial ratio (%), and the results are shown in Table 1.
TABLE 1 toothpaste bactericidal ratio (%)
| Toothpaste tube | 1 | 2 | D1 | D2 | K1 |
| Escherichia coli | 99.6 | 99.9 | 89.1 | 89.4 | 85.0 |
| Staphylococcus aureus | 99.5 | 99.8 | 80.7 | 82.3 | 78.3 |
| Candida albicans | 99.6 | 99.9 | 76.3 | 81.2 | 75.7 |
| Streptococcus mutans | 99.5 | 99.7 | 79.9 | 82.5 | 80.5 |
As can be seen from table 1, the compound traditional Chinese medicine toothpaste containing subprostrate sophora and pseudo-ginseng prepared in the embodiments 5 and 6 of the present invention has significantly higher sterilization rate on escherichia coli, staphylococcus aureus, candida albicans and streptococcus mutans than the comparative examples.
Experimental example 2
The effect test of treating periodontitis is carried out on the subprostrate sophora and pseudo-ginseng compound traditional Chinese medicine toothpaste prepared in the embodiments 5 and 6 of the invention and the toothpaste prepared in the comparative examples 1-3, and the test method is as follows: 100 periodontitis patients are selected and randomly divided into 5 groups, each group comprises 20 people, each person uses the test toothpaste once in the morning and at night every day, the test toothpaste is continuously used for 2 months, oral cavity examination is carried out on each person before and after the use for 2 months, and the gingival index is adopted for scoring, wherein the scoring standard is as follows: 1-no inflammation; 2-mild inflammation, slight change of gum color and texture; 3-moderate inflammation, bright gum, redness, swelling, hyperplasia; 4-severe inflammation, pronounced redness, hyperplasia of gums, spontaneous bleeding, the scoring results were averaged and are shown in table 2.
TABLE 2 effects on the treatment of periodontitis
| Toothpaste tube | 1 | 2 | D1 | D2 | K1 |
| Mean value before use | 3.5 | 3.8 | 3.6 | 3.5 | 3.9 |
| Average value after use | 1.9 | 1.6 | 2.8 | 2.5 | 3.5 |
As can be seen from table 2, the subprostrate sophora and pseudo-ginseng compound traditional Chinese medicine toothpaste prepared in embodiments 5 and 6 of the present invention has a good effect of treating periodontitis.
While embodiments of the invention have been disclosed above, it is not limited to the applications listed in the description and the embodiments, which are fully applicable in all kinds of fields of application of the invention, and further modifications may readily be effected by those skilled in the art, so that the invention is not limited to the specific details without departing from the general concept defined by the claims and the scope of equivalents.
Claims (6)
1. The compound traditional Chinese medicine toothpaste containing the subprostrate sophora and the pseudo-ginseng is characterized by comprising a subprostrate sophora and pseudo-ginseng composition, wherein the subprostrate sophora and pseudo-ginseng composition accounts for 0.1-1% of the compound traditional Chinese medicine toothpaste containing the subprostrate sophora and the pseudo-ginseng composition, the subprostrate sophora and pseudo-ginseng composition is total saponins of pseudo-ginseng and alkaloid extract of the subprostrate sophora, and the weight ratio of the total saponins of the subprostrate sophora to the alkaloid extract of the subprostrate sophora is 1: 1-10;
the preparation method of the subprostrate sophora alkaloid extract comprises the following steps: adding 7-10 times of water by weight into dried radix Sophorae Tonkinensis medicinal material, reflux-extracting at 98 + -2 deg.C for two times (2 hr each time), filtering, mixing filtrates, and concentrating the filtrate to obtain extract; dissolving the obtained extract with 2-3 weight times of 20-30% ethanol, filtering, adding the obtained filtrate into macroporous resin, eluting with water for 3 column volumes, collecting 2 nd and 3 rd column volumes of water, mixing, and concentrating to obtain extract.
2. The radix sophorae tonkinensis and radix notoginseng compound traditional Chinese medicine toothpaste according to claim 1, wherein the weight percentage of the radix sophorae tonkinensis and radix notoginseng composition in the radix sophorae tonkinensis and radix notoginseng compound traditional Chinese medicine toothpaste is 0.15-0.6%.
3. The compound traditional Chinese medicine toothpaste containing subprostrate sophora and pseudo-ginseng as claimed in any one of claims 1 to 2, which is mainly prepared from the following raw materials in parts by weight: 30-40 parts of calcium carbonate, 5-15 parts of sorbitol, 1-10 parts of hydrated silica, 4-8 parts of glycerol, 80.3-1 parts of polyethylene glycol, 1-3 parts of sodium lauryl sulfate, 1-3 parts of essence, 1-2 parts of cellulose gum, 0.05-0.1 part of panax notoginseng saponins, 0.1-0.5 part of subprostrate sophora alkaloid extract, 0.1-0.3 part of tranexamic acid, 0.5-1 part of carrageen crispus, 0.5-1 part of saccharin sodium, 0.1-0.5 part of methylparaben, 0.1-0.5 part of propylhydroxybenzoate and 0.02-0.04 part of bis-hydroxymethyl imidazolidinyl urea.
4. The preparation method of the compound traditional Chinese medicine toothpaste containing the subprostrate sophora and the pseudo-ginseng is characterized by comprising the following steps: adding the radix sophorae tonkinensis and radix notoginseng composition into a toothpaste matrix, stirring and grinding for 30-60min, aging for 60-180min, naturally cooling the materials to normal temperature, and subpackaging to obtain the compound traditional Chinese medicine toothpaste, wherein the radix sophorae tonkinensis and radix notoginseng composition accounts for 0.1-1% of the weight of the compound traditional Chinese medicine toothpaste, and the radix sophorae tonkinensis and radix notoginseng composition consists of total saponins of radix sophorae tonkinensis and alkaloid extract of radix sophorae tonkinensis in a weight ratio of 1: 1-10;
the preparation method of the subprostrate sophora alkaloid extract comprises the following steps: adding 7-10 times of water by weight into dried radix Sophorae Tonkinensis medicinal material, reflux-extracting at 98 + -2 deg.C for two times (2 hr each time), filtering, mixing filtrates, and concentrating the filtrate to obtain extract; dissolving the obtained extract with 2-3 weight times of 20-30% ethanol, filtering, adding the obtained filtrate into macroporous resin, eluting with water for 3 column volumes, collecting 2 nd and 3 rd column volumes of water, mixing, and concentrating to obtain extract.
5. The preparation method of the compound traditional Chinese medicine toothpaste containing subprostrate sophora and pseudo-ginseng as claimed in claim 4, wherein the toothpaste comprises the following raw materials in parts by weight: 30-40 parts of calcium carbonate, 5-15 parts of sorbitol, 1-10 parts of hydrated silica, 4-8 parts of glycerol, 80.3-1 parts of polyethylene glycol, 1-3 parts of sodium lauryl sulfate, 1-3 parts of essence, 1-2 parts of cellulose gum, 0.05-0.1 part of panax notoginseng saponins, 0.1-0.5 part of subprostrate sophora alkaloid extract, 0.1-0.3 part of tranexamic acid, 0.5-1 part of carrageen crispus, 0.5-1 part of saccharin sodium, 0.1-0.5 part of methylparaben, 0.1-0.5 part of propylhydroxybenzoate and 0.02-0.04 part of bis-hydroxymethyl imidazolidinyl urea.
6. The method for preparing the subprostrate sophora and pseudo-ginseng compound traditional Chinese medicine toothpaste as claimed in claim 4, further comprising, during stirring and grinding, vacuumizing at-0.096 MPa.
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| KR20090079369A (en) * | 2008-01-17 | 2009-07-22 | 주식회사 엘지생활건강 | Toothpaste composition for bamboo salt sustaining specific pH |
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| KR20170121496A (en) * | 2016-04-25 | 2017-11-02 | 치앙 쉬 | Chinese medicinal toothpaste |
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Application publication date: 20190514 Assignee: GUANGXI HENGDERUN BIOLOGICAL SCIENCE & TECHNOLOGY Co.,Ltd. Assignor: GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS Contract record no.: X2023980045685 Denomination of invention: Shandougen Tianqi Compound Traditional Chinese Medicine Toothpaste and Its Preparation Method Granted publication date: 20210824 License type: Common License Record date: 20231106 |