CN111568826A - Oral care composition capable of resisting inflammation, relieving pain and preventing ulcer, oral care toothpaste and preparation method of oral care toothpaste - Google Patents
Oral care composition capable of resisting inflammation, relieving pain and preventing ulcer, oral care toothpaste and preparation method of oral care toothpaste Download PDFInfo
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Abstract
An oral care composition for resisting inflammation, relieving pain and preventing ulcer, an oral care toothpaste and a preparation method of the oral care toothpaste belong to the technical field of toothpaste. The traditional Chinese medicine composition is mainly prepared from 0.3-4 parts by weight of paeonol, 0.3-1.5 parts by weight of pseudo-ginseng extract, 0.1-5 parts by weight of clove basil oil, 0.1-1 part by weight of dipotassium glycyrrhizinate, 0.1-1 part by weight of allantoin and 0-0.1 part by weight of sodium tetraborate. The invention adopts the low-irritation nonionic surfactant and the zwitterionic surfactant, abandons the sodium lauryl sulfate which is commonly used by the traditional toothpaste products and stimulates the skin mucous membrane, does not contain the polyethylene glycol with strong irritation and permeability, and can be better applied to the people suffering from periodontal diseases such as gingivitis, gingival swelling and pain, gingival atrophy, periodontitis, periodontal trauma and the like and people paying attention to oral health.
Description
Technical Field
The invention belongs to the technical field of toothpaste; in particular to an oral care composition for resisting inflammation, relieving pain and preventing ulcer, an oral care toothpaste and a preparation method of the oral care toothpaste.
Background
The common oral problems of people are tooth pain, gum swelling and pain, bleeding inflammation and oral ulcer. People around the world suffer to an extent from oral problems.
Although the toothpaste sold on the market has the effects of solving the problems of gingival bleeding, resisting inflammation, inhibiting swelling and pain of gum, repairing dental ulcer and the like, the toothpaste has the defects of insufficient effective components, unobvious effect, temporary effect, unreasonable formula process and the like, and part of the components adopted in the toothpaste sold on the market, such as sodium lauryl sulfate, polyethylene glycol and the like, have irritation on skin mucosa.
Disclosure of Invention
The invention aims to provide an oral care composition for resisting inflammation, relieving pain and preventing ulcer, an oral care toothpaste thereof and a preparation method of the oral care toothpaste.
The invention is realized by the following technical scheme:
the oral care composition for resisting inflammation, relieving pain and preventing ulcer is mainly prepared from 0.3-4 parts by weight of paeonol, 0.3-1.5 parts by weight of pseudo-ginseng extract, 0.1-5 parts by weight of clove basil oil, 0.1-1 part by weight of dipotassium glycyrrhizinate, 0.1-1 part by weight of allantoin and 0-0.1 part by weight of sodium tetraborate.
The oral care composition for resisting inflammation, relieving pain and preventing ulcer, provided by the invention, comprises 0.3 part by weight of paeonol, 0.5 part by weight of pseudo-ginseng extract, 0.6 part by weight of clove basil oil, 0.5 part by weight of dipotassium glycyrrhizinate, 1 part by weight of allantoin and 0.1 part by weight of sodium tetraborate.
The oral care composition for resisting inflammation, relieving pain and preventing ulcer is characterized in that the oral care composition for resisting inflammation, relieving pain and preventing ulcer is 0.3 part by weight of paeonol, 0.5 part by weight of pseudo-ginseng extract, 0.6 part by weight of clove basil oil, 0.5 part by weight of dipotassium glycyrrhizinate and 0.4 part by weight of allantoin.
The oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer is mainly prepared from 0.3-4 parts by weight of paeonol, 0.3-1.5 parts by weight of panax notoginseng extract, 0.1-5 parts by weight of clove basil oil, 0.1-1 part by weight of dipotassium glycyrrhizinate, 0.1-1 part by weight of allantoin, 0-0.1 part by weight of sodium tetraborate, 8-40 parts by weight of abrasive, 10-45 parts by weight of humectant, 0.2-1.5 parts by weight of thickener, 1-5 parts by weight of surfactant, 0.2-1.0 part by weight of stabilizer, 0.1-0.5 part by weight of whitening agent, 0.1-1.5 parts by weight of preservative and 0.5-0.5 part by weight of preservative, 20-30 parts of purified water.
The invention relates to an oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer, wherein an abrasive agent in the oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer is one or a mixture of two of calcium carbonate, calcium hydrogen phosphate, silicon dioxide, hydrated silica, calcium pyrophosphate and aluminum hydroxide, a humectant is one or a mixture of two of glycerol and sorbitol, a thickening agent is one or a mixture of two of xanthan gum, carbomer, sodium carboxymethylcellulose, sodium alginate, antler pectin and guar gum, a surfactant is one or a mixture of two of alkyl glucoside surfactants, amino acid type amphoteric surfactants and betaine type amphoteric surfactants, a stabilizer is tetrasodium pyrophosphate, a whitening agent is titanium dioxide, and flavoring agents are menthol, peppermint oil, lemon essence, and the like, One or more of tea tree essence, cherry essence, honey peach essence and jasmine essence, and the preservative is one of potassium sorbate and sodium benzoate.
The oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer is characterized in that the alkyl glucoside surfactant in the oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer is one or a mixture of two of octaalkyl glucoside, dodecyl glucoside, tetradecyl glucoside and coco glucoside.
The amino acid type amphoteric surfactant in the oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer is one or a mixture of two of sodium dodecyl aminopropionate, sodium dodecyl dimethylene aminodiformate, Na-acyl lysine and Na-methyl-Na-lauroyl lysine.
The betaine type amphoteric surfactant in the oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer is one or a mixture of two of alkyl betaine, alkyl amido betaine and sulfobetaine.
The preparation method of the oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer, which is disclosed by the invention, comprises the following steps of:
step 1, weighing glycerol according to parts by weight, adding the glycerol into a container, adding a thickening agent, stirring for 3min, adding purified water at room temperature, slowly stirring for 15min to obtain a first mixture, or slowly stirring for 15min, adding sorbitol, and uniformly stirring to obtain a first mixture for later use;
step 2, adding a friction agent into the first mixture obtained in the step 1, and uniformly stirring to obtain a second mixture for later use;
step 3, adding a surfactant into the second mixture obtained in the step 2, uniformly stirring, then sequentially adding paeonol, a pseudo-ginseng extract, dipotassium glycyrrhizinate, allantoin, sodium tetraborate, a sun-screening agent, a preservative and a stabilizer, stirring uniformly, and homogenizing for 50min under a vacuum condition to obtain a third mixture for later use;
and 4, adding the clove basil oil and the flavoring agent into the third mixture obtained in the step 3, uniformly stirring, homogenizing for 10min, and then transferring to a paste storage pot to age for 120min to obtain the oral care toothpaste with the effects of resisting inflammation, relieving pain and preventing ulcer.
The preparation method of the oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer, which is disclosed by the invention, comprises the following steps of:
step 1, weighing purified water according to parts by weight, adding the purified water into a container, then adding sorbitol, uniformly stirring, adding a thickening agent, and stirring for 3min to obtain a first mixture for later use;
step 2, adding a friction agent into the first mixture obtained in the step 1, and uniformly stirring to obtain a second mixture for later use;
step 3, adding a surfactant into the second mixture obtained in the step 2, uniformly stirring, then sequentially adding paeonol, a pseudo-ginseng extract, dipotassium glycyrrhizinate, allantoin, sodium tetraborate, a sun-screening agent, a preservative and a stabilizer, stirring uniformly, and homogenizing for 50min under a vacuum condition to obtain a third mixture for later use;
and 4, adding the clove basil oil and the flavoring agent into the third mixture obtained in the step 3, uniformly stirring, homogenizing for 10min, and then transferring to a paste storage pot to age for 120min to obtain the oral care toothpaste with the effects of resisting inflammation, relieving pain and preventing ulcer.
The paeonol is an effective component extracted from the traditional Chinese medicine cortex moutan, and has the functions of easing pain, resisting inflammation, relieving heat and inhibiting allergic reaction. Has obvious analgesic effect on pain caused by physical or chemical factors such as tail pain, glacial acetic acid and the like. In daily use, paeonol can inhibit intracellular O2-Free radicals are generated, so that the skin can be whitened, deposited pigments in the skin are reduced and discolored, and stasis and spots are removed; also has antiinflammatory, repercussive, analgesic, antiallergic, and antiviral effects.
In the oral care composition for resisting inflammation, relieving pain and preventing ulcer, the saponin in the panax notoginseng extract is a main active ingredient, and comprises ginsenoside Rgl, Rg2, Rbl, Rb2, Rb3, Rc, Rd, Re, Rh, F2, notoginsenoside R1, R2, R3, R6, Fa, Fc, Fe, R4 and the like. The Notoginseng radix total saponin comprises ginsenoside and notoginsenoside, is the main effective active ingredient of Notoginseng radix, and has cardiovascular protection, thrombosis preventing and resisting, pain relieving, antiinflammatory, radiation resisting, antiaging, and antioxidant effects.
The invention relates to an oral care composition for resisting inflammation, relieving pain and preventing ulcer, wherein the oleum Ocimi Gratissimum is volatile oil obtained by steam distillation of whole herb of Ocimum gratissimum L.
The invention relates to an oral care composition for resisting inflammation, relieving pain and preventing ulcer, wherein dipotassium glycyrrhizinate is prepared by taking traditional Chinese medicine liquorice as a raw material, extracting with water, and then adding potassium hydroxide or potassium carbonate for complete neutralization. Is natural sweetener, and has antiinflammatory, antiallergic, antiulcer, and epithelial cell tissue regeneration promoting effects. Compared with sucrose, the sweetness of the sugar is 80-100 times that of sucrose. The dipotassium glycyrrhizinate is a derivative of glycyrrhizic acid, and the anti-inflammatory effect of 0.5 percent dipotassium glycyrrhizinate solution is equivalent to that of 0.1 percent dexamethasone, but no serious adverse reaction exists. The dipotassium glycyrrhizinate is white powder, and has the characteristics of high sweetness, good water solubility, low heat energy, low foamability and hemolytic effect, safety and no toxicity. Meanwhile, dipotassium glycyrrhizinate has the functions of diminishing inflammation, resisting ulcer, resisting oxidation, inhibiting bacteria, treating wounds and effectively removing superoxide ions and hydroxyl free radicals.
According to the oral care composition for resisting inflammation, relieving pain and preventing ulcer, the sodium tetraborate has an antibacterial effect, and has a weak antibacterial effect as boric acid. It has inhibiting effect on Escherichia coli, Pseudomonas aeruginosa, Bacillus anthracis, Shigella flexneri, Shigella shigella, Salmonella typhi, Salmonella paratyphi, Bacillus proteus, Staphylococcus, and Candida albicans, and also has antiseptic and skin mucosa protecting effects.
The allantoin is a derivative of uric acid, is a tasteless and nonirritant white crystal, and is odorless, tasteless, nonirritant and non-allergic. Has the functions of bacteriostasis, diminishing inflammation, promoting cell growth and accelerating wound healing, is a good skin wound healing agent and an anti-ulcer agent, and is often used for treating skin and mucosa injuries.
The oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer removes common irritant substances, namely sodium lauryl sulfate and polyethylene glycol, in the toothpaste, the added paeonol has the functions of relieving swelling and easing pain, the panax notoginseng saponins in the panax notoginseng extract has the functions of diminishing inflammation and stopping bleeding, the eugenol in the clove basil oil has the main functions of relieving fever, easing pain, resisting inflammation and relieving swelling, and the dipotassium glycyrrhizinate has the functions of resisting inflammation, resisting allergy and resisting ulcer. The sodium tetraborate disinfects antisepticise and allantoin bacteriostasis promotes cell growth, the two play an auxiliary role, can further enhance the effects of anti-inflammation, relieving pain and healing wound surfaces, show obvious synergistic effect, are obviously superior to the active ingredients or allantoin of single Chinese medicinal material extract and related derivatives, take the active ingredients of the Chinese medicinal material extract and related derivatives as the basis, adopt nonionic and zwitterionic surfactants to replace the common irritant anionic surfactant sodium lauryl sulfate in the traditional toothpaste, and add allantoin which promotes cell growth and accelerates wound surface healing, can relieve tooth pain and periodontal discomfort of people, keep breath fresh and prevent dental ulcer.
Detailed Description
The first embodiment is as follows:
the oral care composition for resisting inflammation, relieving pain and preventing ulcer is mainly prepared from 0.3-4 parts by weight of paeonol, 0.3-1.5 parts by weight of pseudo-ginseng extract, 0.1-5 parts by weight of clove basil oil, 0.1-1 part by weight of dipotassium glycyrrhizinate, 0.1-1 part by weight of allantoin and 0-0.1 part by weight of sodium tetraborate.
The second embodiment is as follows:
the oral care composition for resisting inflammation, relieving pain and preventing ulcer is prepared from 0.3 part of paeonol, 0.5 part of pseudo-ginseng extract, 0.6 part of clove basil oil, 0.5 part of dipotassium glycyrrhizinate, 1 part of allantoin and 0.1 part of sodium tetraborate.
The third concrete implementation mode:
the oral care composition for resisting inflammation, relieving pain and preventing ulcer is prepared from 0.3 part by weight of paeonol, 0.5 part by weight of pseudo-ginseng extract, 0.6 part by weight of clove basil oil, 0.5 part by weight of dipotassium glycyrrhizinate and 0.4 part by weight of allantoin.
The fourth concrete implementation mode:
an oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer is mainly prepared from 0.3 part by weight of paeonol, 1.0 part by weight of a panax notoginseng extract, 0.8 part by weight of a panax notoginseng extract, 0.5 part by weight of a panax notoginseng oil, 0.4 part by weight of allantoin, 0.3 part by weight of a flavoring agent, 0.5 part by weight of a stabilizer, 0.5 part by weight of a whitening agent, 0.8 part by weight of a flavoring agent, 0.3 part by weight of a preservative and 22.6 parts by weight of purified water.
The oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer in the embodiment is characterized in that the abrasive agent in the oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer is 10 parts of silicon dioxide and 20 parts of hydrated silica, the humectant is 20 parts of sorbitol and 20 parts of glycerin, the thickener is 0.5 part of xanthan gum and 0.3 part of sodium carboxymethyl cellulose, the surfactant is 0.5 part of alkyl glucoside surfactant and 1 part of betaine amphoteric surfactant, the stabilizer is tetrasodium pyrophosphate, the whitening agent is titanium dioxide, the flavoring agent is 0.3 part of menthol, 0.2 part of lemon essence and 0.3 part of tea tree essence, and the preservative is 0.3 part of sodium benzoate.
In the oral care toothpaste for anti-inflammation, analgesia and ulcer prevention according to the embodiment, the alkyl glucoside surfactant in the oral care toothpaste for anti-inflammation, analgesia and ulcer prevention is coco glucoside.
In the oral care toothpaste for anti-inflammation, relieving pain and preventing ulcer, the betaine-type amphoteric surfactant is alkylamidobetaine, and the alkylamidobetaine is cocamidopropyl betaine.
The fifth concrete implementation mode:
according to the fourth embodiment, the preparation method of the oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer comprises the following steps:
step 1, weighing glycerol according to parts by weight, adding the glycerol into a container, adding a thickening agent, stirring for 3min, adding purified water at room temperature, slowly stirring for 15min, adding sorbitol, and continuously stirring to obtain a first mixture for later use;
step 2, adding a friction agent into the first mixture obtained in the step 1, and uniformly stirring to obtain a second mixture for later use;
step 3, adding a surfactant into the second mixture obtained in the step 2, uniformly stirring, then sequentially adding paeonol, a pseudo-ginseng extract, dipotassium glycyrrhizinate, allantoin, sodium tetraborate, a sun-screening agent, a preservative and a stabilizer, stirring uniformly, and homogenizing for 50min under a vacuum condition to obtain a third mixture for later use;
and 4, adding the clove basil oil and the flavoring agent into the third mixture obtained in the step 3, uniformly stirring, homogenizing for 10min, and then transferring to a paste storage pot to age for 120min to obtain the oral care toothpaste with the effects of resisting inflammation, relieving pain and preventing ulcer.
The sixth specific implementation mode:
an oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer is mainly prepared from 0.5 part by weight of paeonol, 1.5 parts by weight of a panax notoginseng extract, 0.5 part by weight of a panax notoginseng oil, 0.4 part by weight of a dipotassium glycyrrhizate, 0.8 part by weight of allantoin, 0.1 part by weight of sodium tetraborate, 30 parts by weight of an abrasive, 40 parts by weight of a humectant, 0.9 part by weight of a thickener, 1.5 parts by weight of a surfactant, 0.6 part by weight of a stabilizer, 0.5 part by weight of a whitening agent, 0.4 part by weight of a flavoring agent, 0.5 part by weight of a preservative and 21.8 parts by weight of purified water.
The oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer, which is disclosed by the embodiment, comprises 20 parts of calcium hydrogen phosphate and 10 parts of hydrated silica as abrasive agents, sorbitol as the humectant, 0.5 part of xanthan gum and 0.4 part of carbomer as the thickening agent, 1.5 parts of betaine amphoteric surfactant as the surfactant, tetrasodium pyrophosphate as the stabilizer, titanium dioxide as the whitening agent, 0.2 part of menthol and 0.2 part of lemon essence as the flavoring agent, and 0.5 part of sodium benzoate as the preservative.
In the oral care toothpaste for anti-inflammation, relieving pain and preventing ulcer, the betaine-type amphoteric surfactant is alkylamidobetaine, and the alkylamidobetaine is cocamidopropyl betaine.
The seventh embodiment:
according to a sixth embodiment, the preparation method of the oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer comprises the following steps:
step 1, weighing purified water according to parts by weight, adding the purified water into a container, then adding sorbitol, uniformly stirring, adding a thickening agent, and stirring for 3min to obtain a first mixture for later use;
step 2, adding a friction agent into the first mixture obtained in the step 1, and uniformly stirring to obtain a second mixture for later use;
step 3, adding a surfactant into the second mixture obtained in the step 2, uniformly stirring, then sequentially adding paeonol, a pseudo-ginseng extract, dipotassium glycyrrhizinate, allantoin, sodium tetraborate, a sun-screening agent, a preservative and a stabilizer, stirring uniformly, and homogenizing for 50min under a vacuum condition to obtain a third mixture for later use;
and 4, adding the clove basil oil and the flavoring agent into the third mixture obtained in the step 3, uniformly stirring, homogenizing for 10min, and then transferring to a paste storage pot to age for 120min to obtain the oral care toothpaste with the effects of resisting inflammation, relieving pain and preventing ulcer.
The specific implementation mode is eight:
an oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer is mainly prepared from 0.3 part by weight of paeonol, 0.5 part by weight of a panax notoginseng extract, 0.6 part by weight of a panax notoginseng extract, 0.5 part by weight of a panax notoginseng oil, 0.5 part by weight of a dipotassium glycyrrhizinate, 1.0 part by weight of allantoin, 0.1 part by weight of sodium tetraborate, 30 parts by weight of an abrasive, 40 parts by weight of a humectant, 0.5 part by weight of a thickener, 1.5 parts by weight of a surfactant, 0.5 part by weight of a stabilizer, 0.3 part by weight of a whitening agent, 0.5 part by weight of a flavoring agent, 0.3 part by weight of a preservative and 22.9 parts by weight of purified water.
The oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer in the embodiment is characterized in that an abrasive agent in the oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer is 30 parts of silicon dioxide, a humectant is 20 parts of sorbitol and 20 parts of glycerin, a thickening agent is 0.5 part of sodium carboxymethylcellulose, a surfactant is 1.5 parts of alkyl glucoside surfactant, a stabilizer is tetrasodium pyrophosphate, a whitening agent is titanium dioxide, a flavoring agent is 0.2 part of menthol and 0.3 part of cherry essence, and a preservative is 0.3 part of sodium benzoate.
In the oral care toothpaste for anti-inflammation, analgesia and ulcer prevention according to the embodiment, the alkyl glucoside surfactant in the oral care toothpaste for anti-inflammation, analgesia and ulcer prevention is coco glucoside.
The specific implementation method nine:
according to the eighth embodiment, the preparation method of the oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer comprises the following steps:
step 1, weighing glycerol according to parts by weight, adding the glycerol into a container, adding a thickening agent, stirring for 3min, adding purified water at room temperature, slowly stirring for 15min, adding sorbitol, and continuously stirring to obtain a first mixture for later use;
step 2, adding a friction agent into the first mixture obtained in the step 1, and uniformly stirring to obtain a second mixture for later use;
step 3, adding a surfactant into the second mixture obtained in the step 2, uniformly stirring, then sequentially adding paeonol, a pseudo-ginseng extract, dipotassium glycyrrhizinate, allantoin, sodium tetraborate, a sun-screening agent, a preservative and a stabilizer, stirring uniformly, and homogenizing for 50min under a vacuum condition to obtain a third mixture for later use;
and 4, adding the clove basil oil and the flavoring agent into the third mixture obtained in the step 3, uniformly stirring, homogenizing for 10min, and then transferring to a paste storage pot to age for 120min to obtain the oral care toothpaste with the effects of resisting inflammation, relieving pain and preventing ulcer.
The detailed implementation mode is ten:
an oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer is mainly prepared from 0.5 part by weight of paeonol, 0.8 part by weight of a panax notoginseng extract, 0.3 part by weight of a panax notoginseng oil, 0.3 part by weight of a dipotassium glycyrrhizinate, 0.3 part by weight of an allantoin, 0.1 part by weight of a sodium tetraborate, 35 parts by weight of an abrasive, 40 parts by weight of a humectant, 1 part by weight of a thickener, 2 parts by weight of a surfactant, 1 part by weight of a stabilizer, 0.4 part by weight of a whitening agent, 0.7 part by weight of a flavoring agent, 0.5 part by weight of a preservative and 17.1 part by weight of purified water.
The oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer, according to the embodiment, the abrasive agent in the oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer is 25 parts of silicon dioxide and 10 parts of calcium carbonate, the humectant is 20 parts of sorbitol and 20 parts of glycerin, the thickener is 0.5 part of xanthan gum and 0.5 part of guar gum, the surfactant is 1 part of alkyl glucoside surfactant and 1 part of amino acid type amphoteric surfactant, the stabilizer is tetrasodium pyrophosphate, the whitening agent is titanium dioxide, the flavoring agent is 0.4 part of menthol and 0.3 part of tea tree essence, and the preservative is 0.3 part of potassium sorbate.
In the oral care toothpaste for anti-inflammation, analgesia and ulcer prevention according to the embodiment, the alkyl glucoside surfactant in the oral care toothpaste for anti-inflammation, analgesia and ulcer prevention is coco glucoside.
In the oral care toothpaste for anti-inflammation, relieving pain and preventing ulcer according to the embodiment, the amino acid type amphoteric surfactant in the oral care toothpaste for anti-inflammation, relieving pain and preventing ulcer is sodium dodecylaminopropionate.
The concrete implementation mode eleven:
a method for preparing an anti-inflammatory, analgesic, and antiulcer oral care toothpaste according to embodiment ten, comprising the steps of:
step 1, weighing glycerol according to parts by weight, adding the glycerol into a container, adding a thickening agent, stirring for 3min, adding purified water at room temperature, slowly stirring for 15min, adding sorbitol, and continuously stirring to obtain a first mixture for later use;
step 2, adding a friction agent into the first mixture obtained in the step 1, and uniformly stirring to obtain a second mixture for later use;
step 3, adding a surfactant into the second mixture obtained in the step 2, uniformly stirring, then sequentially adding paeonol, a pseudo-ginseng extract, dipotassium glycyrrhizinate, allantoin, sodium tetraborate, a sun-screening agent, a preservative and a stabilizer, stirring uniformly, and homogenizing for 50min under a vacuum condition to obtain a third mixture for later use;
and 4, adding the clove basil oil and the flavoring agent into the third mixture obtained in the step 3, uniformly stirring, homogenizing for 10min, and then transferring to a paste storage pot to age for 120min to obtain the oral care toothpaste with the effects of resisting inflammation, relieving pain and preventing ulcer.
The specific implementation mode twelve:
an oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer is mainly prepared from 0.5 part by weight of paeonol, 0.5 part by weight of a panax notoginseng extract, 0.3 part by weight of a panax notoginseng extract, 0.5 part by weight of a panax notoginseng oil, 0.3 part by weight of a panax notoginseng oil, 0.5 part by weight of a dipotassium glycyrrhizinate, 0.4 part by weight of allantoin, 0.1 part by weight of sodium tetraborate, 25 parts by weight of an abrasive, 40 parts by weight of a humectant, 0.8 part by weight of a thickener, 2 parts by weight of a surfactant, 0.6 part by weight of a stabilizer, 0.3 part by weight of a whitening agent, 0.4 part by weight of a flavoring agent, 0.3 part by weight of a preservative and 28 parts by weight of purified water.
The oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer in the embodiment is characterized in that the abrasive agent in the oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer is 15 parts of calcium hydrogen phosphate and 10 parts of aluminum hydroxide, the humectant is 40 parts of sorbitol, the thickening agent is 0.4 part of xanthan gum and 0.4 part of sodium carboxymethyl cellulose, the surfactant is 1.0 part of amino acid type amphoteric surfactant and 1.0 part of betaine type amphoteric surfactant, the stabilizer is tetrasodium pyrophosphate, the whitening agent is titanium dioxide, the flavoring agent is 0.2 part of menthol, 0.2 part of honey peach essence and the preservative is 0.3 part of sodium benzoate.
In the oral care toothpaste for anti-inflammation, relieving pain and preventing ulcer according to the embodiment, the amino acid type amphoteric surfactant in the oral care toothpaste for anti-inflammation, relieving pain and preventing ulcer is sodium dodecylaminopropionate.
In the oral care toothpaste for anti-inflammation, relieving pain and preventing ulcer, the betaine-type amphoteric surfactant is alkylamidobetaine, and the alkylamidobetaine is cocamidopropyl betaine.
The specific implementation mode is thirteen:
the preparation method of the oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer according to the embodiment twelve comprises the following steps:
step 1, weighing purified water according to parts by weight, adding the purified water into a container, then adding sorbitol, uniformly stirring, adding a thickening agent, and stirring for 3min to obtain a first mixture for later use;
step 2, adding a friction agent into the first mixture obtained in the step 1, and uniformly stirring to obtain a second mixture for later use;
step 3, adding a surfactant into the second mixture obtained in the step 2, uniformly stirring, then sequentially adding paeonol, a pseudo-ginseng extract, dipotassium glycyrrhizinate, allantoin, sodium tetraborate, a sun-screening agent, a preservative and a stabilizer, stirring uniformly, and homogenizing for 50min under a vacuum condition to obtain a third mixture for later use;
and 4, adding the clove basil oil and the flavoring agent into the third mixture obtained in the step 3, uniformly stirring, homogenizing for 10min, and then transferring to a paste storage pot to age for 120min to obtain the oral care toothpaste with the effects of resisting inflammation, relieving pain and preventing ulcer.
Preparation of blank control sample:
the formulation of the blank sample was as follows: 20g of glycerin, 20g of sorbitol, 10g of calcium carbonate, 25g of silicon dioxide, 1.5g of coco glucoside, 0.5g of xanthan gum, 1.0g of tetrasodium pyrophosphate, 0.5g of potassium sorbate, 0.4g of titanium dioxide, 0.3g of menthol, 0.3g of tea refreshing essence and the balance of purified water.
The preparation method of the blank sample comprises the following steps: weighing glycerol according to requirements, adding a thickening agent, stirring for 3 minutes to uniformly disperse the glycerol, adding purified water with a specified required amount at room temperature, slowly stirring for 15 minutes, adding sorbitol, and stirring uniformly; continuously adding the friction agent into the container and uniformly mixing; after finishing, adding a surfactant, mixing uniformly, then sequentially adding titanium dioxide, potassium sorbate, tetrasodium pyrophosphate and menthol, mechanically stirring and homogenizing to ensure that the paste is fully mixed uniformly and ground to be fine; simultaneously vacuumizing to-0.096 MPa, removing air bubbles in the paste, and homogenizing for 50 minutes; adding the tea refreshing essence after finishing, and continuing homogenizing for 10 minutes; aging for 120 minutes after finishing to obtain the oral care composition.
The oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer, which is described in the fourth embodiment, the sixth embodiment and the eighth embodiment, is subjected to a bacteriostasis test with a blank sample, and the oral care composition of the invention is subjected to the bacteriostasis test with staphylococcus aureus, pseudomonas aeruginosa and candida albicans by using a plate method, and the results are shown in table 1:
TABLE 1 bacteriostasis test
As can be seen from the table 1, the oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer has obvious antibacterial effect and meets the standard requirements of oral inhibition products.
An anti-inflammatory, analgesic, and ulcer preventing oral care toothpaste according to embodiment four was subjected to plaque inhibition tests with a blank sample, and the results are shown in table 2:
TABLE 2 Plaque Index (PI) comparison
As can be seen from table 2, in the plaque inhibition test, the plaque indexes (PI comparison) before and after two groups of oral care toothpastes were analyzed by the group t test in comparison with the blank control group, the plaque amount of the anti-inflammatory, analgesic, and ulcer preventing oral care toothpaste was significantly reduced, and was different from and statistically significant (P < 0.05) in comparison with the blank control group, and the anti-inflammatory, analgesic, and ulcer preventing oral care toothpaste showed the efficacy of inhibiting plaque.
The oral care toothpaste for anti-inflammation, relieving pain and preventing ulcer according to the fourth embodiment and a blank sample are subjected to a gingival bleeding condition test, and the results are shown in table 3:
TABLE 3 gingival Bleeding Index (BI)
| Group of | Number of examples | Day 0 | One month | Two months old | Three months old |
| Detailed description of the invention | 33 | 2.61±0.54 | 1.83±0.53 | 1.66±0.44 | 1.51±0.41 |
| Blank control | 33 | 2.56±0.61 | 2.34±0.55 | 2.28±0.46 | 2.23±0.41 |
As can be seen from Table 3, the comparison of the final values of the respective indices of the control group and the oral care toothpaste for anti-inflammatory, analgesic and antiulcer (test group) satisfies (control-test)/control of 12% or more, the indices of gingival Bleeding Index (BI) before and after use of the toothpaste in the two groups were analyzed by paired t-test and had statistical significance (P < 0.05), and the arithmetic mean of the percentage reduction of the two tests was: 32.50 percent is more than or equal to 15 percent, and the oral care toothpaste with the functions of resisting inflammation, relieving pain and preventing ulcer has the effect of reducing gingival inflammation.
The oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer of the fourth embodiment, the sixth embodiment and the eighth embodiment and a blank sample are subjected to an ulcer healing test, a traumatic oral ulcer animal model is adopted, and an animal model establishment method comprises the following steps: a glass tube with the inner diameter of 0.6cm and the length of 3cm is vertically fixed on the surface of oral mucosa of the rabbit, 0.2ml of glacial acetic acid with the volume fraction of 30% is injected into the glass tube, the glacial acetic acid is dipped by a cotton swab after 30 seconds, the ulcer is formed the next day, and the diameter of the ulcer is generally about 0.2-0.3 cm. Every six hours after dosing, no mucosal ulceration and congestion were observed as healing criteria, and the results are shown in table 4:
TABLE 4 ulcer healing test
| Group of | Datum | 6h | 12h | 18h | 24h | 30h | 36h | 42h | 48h |
| Blank control | 30 | 30 | 21 | 10 | 5 | 3 | 1 | 0 | 0 |
| Detailed description of the invention | 30 | 29 | 17 | 0 | 0 | 0 | 0 | 0 | 0 |
| Detailed description of the invention | 30 | 30 | 18 | 0 | 0 | 0 | 0 | 0 | 0 |
| Detailed description of the invention | 30 | 28 | 15 | 0 | 0 | 0 | 0 | 0 | 0 |
As can be seen from Table 4, the ulcers on the oral mucosa of the animal all healed over 42h, the ulcers healed most rapidly (P < 0.05) for the group using the anti-inflammatory, analgesic, ulcer-preventing oral care toothpaste, and all the ulcers healed within 18h using the anti-inflammatory, analgesic, ulcer-preventing oral care toothpaste.
Therefore, the oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer in the specific embodiment contains various anti-inflammation and antibacterial components, and can effectively improve gum swelling and pain, reduce oral bacteria, remove oral peculiar smell, prevent oral ulcer and the like. The oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer adopts the low-irritation nonionic surfactant and the zwitterionic surfactant, abandons sodium lauryl sulfate which is commonly used in traditional toothpaste products and is used for irritating skin mucous membranes, does not contain polyethylene glycol with strong irritation and permeability, and can be better applied to people with periodontal diseases such as gingivitis, gingival swelling and pain, gingival atrophy, periodontitis, periodontal wounds and the like and people paying attention to oral health.
Claims (10)
1. An anti-inflammatory, analgesic, ulcer preventing oral care composition characterized by: the oral care composition for resisting inflammation, relieving pain and preventing ulcer is mainly prepared from 0.3-4 parts by weight of paeonol, 0.3-1.5 parts by weight of pseudo-ginseng extract, 0.1-5 parts by weight of clove basil oil, 0.1-1 part by weight of dipotassium glycyrrhizinate, 0.1-1 part by weight of allantoin and 0-0.1 part by weight of sodium tetraborate.
2. An anti-inflammatory analgesic, antiulcer oral care composition according to claim 1, wherein: in the oral care composition for resisting inflammation, relieving pain and preventing ulcer, the paeonol accounts for 0.3 part by weight, the pseudo-ginseng extract accounts for 0.5 part by weight, the clove basil oil accounts for 0.6 part by weight, the dipotassium glycyrrhizinate accounts for 0.5 part by weight, the allantoin accounts for 1 part by weight, and the sodium tetraborate accounts for 0.1 part by weight.
3. An anti-inflammatory analgesic, antiulcer oral care composition according to claim 1, wherein: in the oral care composition for resisting inflammation, relieving pain and preventing ulcer, the paeonol accounts for 0.3 part by weight, the pseudo-ginseng extract accounts for 0.5 part by weight, the clove basil oil accounts for 0.6 part by weight, the dipotassium glycyrrhizinate accounts for 0.5 part by weight, and the allantoin accounts for 0.4 part by weight.
4. An oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer, which is characterized in that: the oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer is mainly prepared from 0.3-4 parts by weight of paeonol, 0.3-1.5 parts by weight of pseudo-ginseng extract, 0.1-5 parts by weight of clove basil oil, 0.1-1 part by weight of dipotassium glycyrrhizinate, 0.1-1 part by weight of allantoin, 0-0.1 part by weight of sodium tetraborate, 8-40 parts by weight of rubbing agent, 10-45 parts by weight of humectant, 0.2-1.5 parts by weight of thickening agent, 1-5 parts by weight of surfactant, 0.2-1.0 part by weight of stabilizing agent, 0.1-0.5 part by weight of whitening agent, 0.1-1.5 parts by weight of flavoring agent, 0.1-0.5 part by weight of preservative and 30-30 parts by weight of purified water.
5. An anti-inflammatory analgesic, antiulcer oral care toothpaste as claimed in claim 4, wherein: the anti-inflammatory, analgesic and ulcer-preventing oral care toothpaste comprises an abrasive agent selected from one or a mixture of two of calcium carbonate, calcium hydrogen phosphate, silicon dioxide, hydrated silica, calcium pyrophosphate and aluminum hydroxide, a humectant selected from one or a mixture of two of glycerol and sorbitol, a thickening agent selected from one or a mixture of two of xanthan gum, carbomer, sodium carboxymethylcellulose, sodium alginate, antler pectin and guar gum, a surfactant selected from one or a mixture of two of alkyl glucoside surfactants, amino acid type amphoteric surfactants and betaine type amphoteric surfactants, a stabilizer selected from tetrasodium pyrophosphate, a whitening agent selected from titanium dioxide, and a flavoring agent selected from one or a mixture of more of menthol, peppermint oil, lemon essence, tea tree essence, cherry essence, honey peach essence and jasmine essence, the antiseptic is one of potassium sorbate and sodium benzoate.
6. An anti-inflammatory analgesic, antiulcer oral care toothpaste as claimed in claim 5, wherein: the alkyl glucoside surfactant in the oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer is one or a mixture of two of octaalkyl glucoside, dodecyl glucoside, tetradecyl glucoside and coco glucoside.
7. An anti-inflammatory analgesic, antiulcer oral care toothpaste as claimed in claim 5, wherein: the amino acid type amphoteric surfactant in the oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer is one or a mixture of two of sodium dodecyl aminopropionate, sodium dodecyl dimethylene amino diformate, Na-acyl lysine and Na-methyl-Na-lauroyl lysine.
8. An anti-inflammatory analgesic, antiulcer oral care toothpaste as claimed in claim 5, wherein: the betaine type amphoteric surfactant in the oral care toothpaste for resisting inflammation, relieving pain and preventing ulcer is one or a mixture of two of alkyl betaine, alkyl amido betaine and sulfobetaine.
9. A method of preparing an anti-inflammatory, analgesic, antiulcer oral care dentifrice of claims 4 to 8 comprising the steps of:
step 1, weighing glycerol according to parts by weight, adding the glycerol into a container, adding a thickening agent, stirring for 3min, adding purified water at room temperature, slowly stirring for 15min to obtain a first mixture, or slowly stirring for 15min, adding sorbitol, and uniformly stirring to obtain a first mixture for later use;
step 2, adding a friction agent into the first mixture obtained in the step 1, and uniformly stirring to obtain a second mixture for later use;
step 3, adding a surfactant into the second mixture obtained in the step 2, uniformly stirring, then sequentially adding paeonol, a pseudo-ginseng extract, dipotassium glycyrrhizinate, allantoin, sodium tetraborate, a sun-screening agent, a preservative and a stabilizer, stirring uniformly, and homogenizing for 50min under a vacuum condition to obtain a third mixture for later use;
and 4, adding the clove basil oil and the flavoring agent into the third mixture obtained in the step 3, uniformly stirring, homogenizing for 10min, and then transferring to a paste storage pot to age for 120min to obtain the oral care toothpaste with the effects of resisting inflammation, relieving pain and preventing ulcer.
10. A method of preparing an anti-inflammatory, analgesic, antiulcer oral care dentifrice of claims 4 to 8 comprising the steps of:
step 1, weighing purified water according to parts by weight, adding the purified water into a container, then adding sorbitol, uniformly stirring, adding a thickening agent, and stirring for 3min to obtain a first mixture for later use;
step 2, adding a friction agent into the first mixture obtained in the step 1, and uniformly stirring to obtain a second mixture for later use;
step 3, adding a surfactant into the second mixture obtained in the step 2, uniformly stirring, then sequentially adding paeonol, a pseudo-ginseng extract, dipotassium glycyrrhizinate, allantoin, sodium tetraborate, a sun-screening agent, a preservative and a stabilizer, stirring uniformly, and homogenizing for 50min under a vacuum condition to obtain a third mixture for later use;
and 4, adding the clove basil oil and the flavoring agent into the third mixture obtained in the step 3, uniformly stirring, homogenizing for 10min, and then transferring to a paste storage pot to age for 120min to obtain the oral care toothpaste with the effects of resisting inflammation, relieving pain and preventing ulcer.
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