CN102552061A - Toothpaste for effectively improving halitosis - Google Patents
Toothpaste for effectively improving halitosis Download PDFInfo
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- CN102552061A CN102552061A CN2012100368103A CN201210036810A CN102552061A CN 102552061 A CN102552061 A CN 102552061A CN 2012100368103 A CN2012100368103 A CN 2012100368103A CN 201210036810 A CN201210036810 A CN 201210036810A CN 102552061 A CN102552061 A CN 102552061A
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Abstract
The invention discloses toothpaste for improving halitosis. The toothpaste is characterized in that: at least two of 0.1-1 percent by weight of paeonol, 0.01-0.1 percent by weight of allantoin and 0.1-1 percent by weight of D-panthenol are added into the conventional toothpaste ingredients. More than two active ingredients are added into the conventional toothpaste ingredients, and active matters co-act in a tooth-brushing process, so that the toothpaste has the effects of relieving swelling and pain, resisting inflammation, inhibiting ulcers, promoting cell growth, improving oral environment, effectively removing halitosis and improving oral peculiar.
Description
Technical field
The present invention relates to a kind of can be effectively to halitosis, improve the toothpaste of oral environment.
Technical background
Halitosis is also claimed halitosis, is meant intraoral bad smell.Voracious maror or eating and drinking too much at one meal, overfatigue, the sense pathogenic heat, asthenic fire pent-up, or some oral disease can cause that like oral ulcer, dental caries and digestive system disease implication is clouding.Most of halitosis are relevant with the ecological environment in oral disease and oral cavity.The oral cavity is unclean, the accumulation of bacterial plaque, tartar, tartar is to cause the most directly reason of halitosis.The patient who suffers from chronic gingivitis and periodontitis, because swelling and aching of gum, hemorrhage, purulent discharge of pocket, oral hygiene situation are very poor, the bacterial plaque of piling up on the tooth, tartar and tartar are under antibacterial and action of microorganisms, the corruption fermentation produces niff.The patient who suffers from necrotic gingivitis, malignant tumor and postextraction infection because slough decompose to suppurate the back produce that earthworm is made an uproar, sulfydryl etc., so the corruptibility halitosis can be arranged.In addition, exist the dental caries not have to treat, undesirable root, residual crown, bad dummy etc. all to be prone to accumulate food debris and dirt in the oral cavity, produce a kind of unpleasant halitosis.Though toothpaste is requisite article of everyday use in people's daily life, everyone sooner or later will use toothpaste to brush teeth in every day usually, and it can not only clean and take care of one's teeth, more can be directly and improve oral environment fast.Though conventional toothpaste can have cleaning oral cavity to improve the effect of implication to a certain extent, the effect that is directed against halitosis is also not obvious, let alone is the long-acting inhibition halitosis of ability, and can improve oral environment through the use of certain hour, suppresses and prevent the generation of halitosis.So, develop a kind ofly except the common cleaning action of toothpaste, can also improve the toothpaste of halitosis symptom, in the hope of satisfying the needs that people suppress halitosis and oral cavity health.
Summary of the invention
For addressing the above problem, the purpose of this invention is to provide a kind of effective toothpaste that improves halitosis, its can let people in the process of brushing teeth every day through improving oral environment, suppress and the generation of prevention halitosis.
Content of the present invention is to realize like this; A kind of effective toothpaste that improves halitosis is characterized in that: in conventional toothpaste component, count by weight percentage at least two kinds in the D-panthenol that adds 0.1～1% paeonol, 0.01～0.1% allantoin and 0.1～1%.
The present invention is through adding two or more active component in conventional toothpaste component, the synergism through active matter in the process of brushing teeth can reducing swelling and alleviating pain, and antiinflammatory presses down ulcer, promotes the cell growth, improves oral environment, effectively removes halitosis and improves halitosis.
The specific embodiment
The present invention is a kind of toothpaste of antihalitosis, and through in toothpaste, adding two or more in paeonol, allantoin and the D-panthenol, Chinese and Western combines, and lets people in the process of brushing teeth every day, can effectively remove halitosis.
Paeonol is a kind of Chinese crude drug that from the root bark of Flos Moutan, extracts; And Cortex Moutan have reduce body temperature, blood circulation promoting, calm the nerves analgesic, remove effect such as halitosis; For a long time; Adopt Cortex Moutan as medicinal on the Chinese medicine, visible its safety and effect property can guarantee always.The content of paeonol is 0.1～1%, and is preferred 0.2～0.8%, most preferably 0.3～0.7%.
Allantoin is a kind of hydantoin derivatives, and its nontoxic, non-stimulated, no anaphylaxis once was called as counter-stimulus, extensively was present in animals and plants circle such as allantois liquid, Radix Betae, Fructus Tritici aestivi, tobacco seed.It can directly use and also can be used as additive, and it can promote the cell growth, accelerating wound, and the proteic function of soften cuticle is the advantages of good skin Wound healing agent.Can make skin and organized renewing looks originally, be used for oral-cavity article and can restrain oral cavity, gingiva wound, promote the regeneration and the healing of epidermis cell.The content of allantoin is 0.01～0.1%, and is preferred 0.03～0.08%, most preferably is 0.04～0.07%.
D-panthenol promotes the metabolism of human body protein, fat, saccharide as hardening agent and nutritional supplement, improves oral mucosa immunity; Preventing and reduce the generation of oral disease, also is the wetting agent of infiltration, stimulates the growth of gingival epithelium cell; Promote wound healing; Play antiinflammation, can participate in body metabolism simultaneously, replenish the needed by human body mcg vitamin.The content of D-panthenol is 0.1～1%, and is preferred 0.2～0.8%, most preferably 0.3～0.7%.
The present invention is an example with a kind of dentifrice composition, is the active component except comprising paeonol, allantoin and D-panthenol, also comprises conventional ingredients such as abrasivus, wetting agent, binding agent, foaming agent, sweeting agent, antiseptic, buffer agent and essence.
Abrasivus can adopt a kind of or combination in calcium carbonate, calcium hydrogen phosphate, silicon dioxide, the aluminium hydroxide to use, and consumption is 15%～55% among the present invention.
Wetting agent can adopt glycerol, sorbitol, Polyethylene Glycol, betanin or propylene glycol, can adopt separately or multiple combination use, and consumption is 30%～55% among the present invention.
In general binding agent can select one or more combinations of carmellose, NATROSOL 250, xanthan gum, guar gum, Magnesiumaluminumsilicate etc. for use, and consumption is 0.5%～2.0%.
Foaming agent can adopt sodium lauryl sulphate, Glycine sodium, sodium sarcosinate or cocamido propyl betaine, can use or make up use separately, and its consumption is 1.5%～3.0%.
Sweeting agent can adopt saccharin sodium, glycyrrhizic acid, sucralose or aspartame, can use separately or composite use, and consumption is 0.1%～0.4%.
Antiseptic then can be selected sodium benzoate or parabens for use, can use separately or composite use, and consumption is 0.05%～0.25%.
Buffer agent can be selected sodium phosphate for use, and tetrasodium pyrophosphate or metaphosphate etc. can use or make up use separately, and consumption is 0.1%～1.0%.
Essence adopts edible essence, and consumption is 0.5%～1.5%.
Reference examples 1
Count by weight percentage, prescription comprises following component:
Wetting agent (sorbitol and mixed with propylene glycol) 50%, abrasivus (silicon dioxide) 20%, binding agent 1.1%, foaming agent 2.0%, sweeting agent 0.2%, antiseptic 0.2%, buffer agent 0.2%, essence 1.1%, water surplus.
Method for preparing: sweeting agent, buffer agent and antiseptic are dissolved in water fully; Wetting agent is added in the system cream pot; Again foaming agent, binding agent, abrasivus are mixed together in the adding pot, add essence behind the fine vacuum mix homogeneously again, treat that essence and mastic mix homogeneously get final product.
Reference examples 2
Count by weight percentage, prescription comprises following component:
Wetting agent (sorbitol and mixed with propylene glycol) 50%, abrasivus (silicon dioxide) 20%, binding agent 1.1%, foaming agent 2.0%, sweeting agent 0.2%, antiseptic 0.2%, buffer agent 0.2%, essence 1.1%, paeonol 0.3% and water surplus.
Method for preparing: the toothpaste matrix method for making is with reference to the blank example, and paeonol is dissolved in to add in the essence and gets final product.
Embodiment 1
Count by weight percentage, prescription comprises following component:
Wetting agent (sorbitol and mixed with propylene glycol) 50%, abrasivus (silicon dioxide) 20%, binding agent 1.1%, foaming agent 2.0%, sweeting agent 0.2%, antiseptic 0.2%, buffer agent 0.2%, essence 1.1%, paeonol 0.3%, allantoin 0.05% and water surplus.
Method for preparing: with reference to embodiment 1, allantoin is dissolved in the water to add and gets final product.
Embodiment 2
Count by weight percentage, prescription comprises following component:
Wetting agent (sorbitol and mixed with propylene glycol) 50%, abrasivus (silicon dioxide) 20%, binding agent 1.1%, foaming agent 2.0%, sweeting agent 0.2%, antiseptic 0.2%, buffer agent 0.2%, essence 1.1%, paeonol 0.3%, D-panthenol 0.5% and water surplus.
Method for preparing: with reference to embodiment 1, D-panthenol is dissolved in the water to add and gets final product.
Embodiment 3
Count by weight percentage, prescription comprises following component:
Wetting agent (sorbitol and mixed with propylene glycol) 50%, abrasivus (silicon dioxide) 20%, binding agent 1.1%, foaming agent 2.0%, sweeting agent 0.2%, antiseptic 0.2%, buffer agent 0.2%, essence 1.1%, paeonol 0.3%, allantoin 0.05%, D-panthenol 0.5% and water surplus.
Method for preparing: sweeting agent, buffer agent, D-panthenol, allantoin and antiseptic are dissolved in water fully; Wetting agent is added in the system cream pot, again foaming agent, binding agent, abrasivus are mixed together in the adding pot, behind the fine vacuum mix homogeneously; Paeonol is dissolved in essence, add again.Treat that essence and mastic mix homogeneously get final product.
Embodiment 4
Count by weight percentage, prescription comprises following component:
Wetting agent (sorbitol and glycerol) 25%, abrasivus (stone powder and silicon dioxide) 45%, binding agent 1.2%, foaming agent 2.5%, sweeting agent 0.25%, antiseptic 0.2%, buffer agent 0.2%, essence 1.2%, paeonol 0.1%, allantoin 0.01%, D-panthenol 0.1% and water surplus.
Method for preparing is with embodiment 3.
Embodiment 5
Wetting agent (sorbitol and mixed with propylene glycol) 50%, abrasivus (silicon dioxide) 20%, binding agent 1.1%, foaming agent 2.0%, sweeting agent 0.2%, antiseptic 0.2%, buffer agent 0.2%, essence 1.1%, paeonol 0.5%, allantoin 0.1%, D-panthenol 1% and water surplus.
Method for preparing: with embodiment 3.
The effect detection experiment
In the experiment of oral cavity, contrast toothpaste embodiment 1～5 and inhibition and the improvement effect of reference examples 1～2 for halitosis.
Compare experiment to 25 subjects (suffering from halitosis in various degree).All experimental subjecies are measured its volatile sulfide (VSC) content with the halitosis detector earlier, measure by following mode.Subjects is remained silent between measuring, through nose breathing 2min.To pop one's head in and insert in the subjects mouth about 2cm and kept about 20 seconds, tongue can not contact with popping one's head in this process.Be divided into 5 groups according to resultant data by degree weight difference, re-use the toothpaste that provides and brush teeth once, time 3min.Brush teeth and finish to measure the halitosis level once more with the halitosis detector behind the 5min, measure once again behind the 30min, whether can keep to confirm effect.All subjects keep the oral cavity closed in process of the test, through nose breathing.
Result of the test is seen table 1.
Table 1 halitosis suppresses the improvement rate
Unit: %=(the back measured value ÷ that brushes teeth brush teeth preceding measured value) * 100%
Shown in table 1 data,, compare with matched group for the inhibitory action of halitosis; Embodiment 1～4 has the obvious suppression effect behind the 10min that brushes teeth; Wherein example 2～4 is superior to example 1, and is being superior to having better effect aspect continuity and the persistency, and 4 of embodiment are reaching best effect aspect effectiveness and the persistence; It is thus clear that embodiment 2 and 3 couples of embodiment 1 have tangible reinforcement and extending function.Allantoin is good epidermis Wound healing agent, is used for oral-cavity article and can restrains oral cavity, gingiva wound, promotes the regeneration and the healing of epidermis cell.As everyone knows, oral disease can cause halitosis, and the easy reason of suffering from oral disease is the shortage of vitamin, and the interpolation of D-panthenol here is in order to improve oral environment from oral health, to help the prevention and the improvement of halitosis.This shows that three kinds of active component can play complementary synergy, simultaneously result of use is best, and halitosis is improved significantly with inhibitory action and helps the health in oral cavity.
In sum; The invention provides and a kind ofly can suppress halitosis, improve oral environment, keep the toothpaste of oral health; It is except the composition that conventional toothpaste comprises, and the spy has added paeonol, allantoin and D-panthenol as active component, and this toothpaste can effectively suppress halitosis; Remove halitosis, keep breath freshening.
Claims (10)
1. toothpaste that effectively improves halitosis is characterized in that: in conventional toothpaste component, count by weight percentage at least two kinds in the D-panthenol that adds 0.1～1% paeonol, 0.01～0.1% allantoin and 0.1～1%.
2. a kind of effective toothpaste that improves halitosis according to claim 1 is characterized in that: in conventional toothpaste component, count by weight percentage the D-panthenol that adds 0.1～1% paeonol, 0.01～0.1% allantoin and 0.1～1%.
3. a kind of effective toothpaste that improves halitosis according to claim 1 is characterized in that: in conventional toothpaste component, count by weight percentage the D-panthenol that adds 0.2～0.8% paeonol, 0.03～0.08% allantoin and 0.2～0.8%.
4. a kind of effective toothpaste that improves halitosis according to claim 1 is characterized in that: in conventional toothpaste component, count by weight percentage the D-panthenol that adds 0.3～0.7% paeonol, 0.04～0.07% allantoin and 0.3～0.7%.
5. according to the described a kind of effective toothpaste that improves halitosis of arbitrary claim among the claim 1-4, it is characterized in that: described conventional toothpaste component comprises two or more in abrasivus, wetting agent, binding agent, foaming agent, sweeting agent, antiseptic, buffer agent, the essence.
6. a kind of effective toothpaste that improves halitosis according to claim 5 is characterized in that: one or more mixing that described abrasivus is selected from calcium carbonate, calcium hydrogen phosphate, silicon dioxide, the aluminium hydroxide are used.
7. a kind of effective toothpaste that improves halitosis according to claim 5 is characterized in that: one or more mixing that described wetting agent is selected from glycerol, sorbitol, Polyethylene Glycol, betanin or the propylene glycol are used.
8. a kind of effective toothpaste that improves halitosis according to claim 5 is characterized in that: one or more mixing that described binding agent is selected from carmellose, NATROSOL 250, xanthan gum, guar gum, the Magnesiumaluminumsilicate are used.
9. a kind of effective toothpaste that improves halitosis according to claim 5 is characterized in that: one or more mixing that described foaming agent is selected from sodium lauryl sulphate, Glycine sodium, sodium sarcosinate or the cocamido propyl betaine are used.
10. a kind of effective toothpaste that improves halitosis according to claim 5, it is characterized in that: described buffer agent is selected from sodium phosphate, and one or more in tetrasodium pyrophosphate or the metaphosphate mix use.
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| CN2012100368103A CN102552061A (en) | 2012-02-17 | 2012-02-17 | Toothpaste for effectively improving halitosis |
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| CN2012100368103A CN102552061A (en) | 2012-02-17 | 2012-02-17 | Toothpaste for effectively improving halitosis |
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Cited By (8)
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| CN103536451A (en) * | 2013-11-01 | 2014-01-29 | 广州市倩采化妆品有限公司 | Traditional Chinese medicine toothpaste and preparation method thereof |
| CN105796379A (en) * | 2016-05-06 | 2016-07-27 | 青岛蓝百合生物科技有限公司 | Water soluble chitosan oral care solution and preparation method thereof |
| CN108652998A (en) * | 2018-06-22 | 2018-10-16 | 中山遇美生物科技有限公司 | A kind of nursing tooth liquid and preparation method thereof improving oral inflammation |
| CN108652992A (en) * | 2018-06-22 | 2018-10-16 | 中山遇美生物科技有限公司 | A kind of canker sore repairs tooth liquid and preparation method thereof |
| CN108785115A (en) * | 2018-06-22 | 2018-11-13 | 中山遇美生物科技有限公司 | A kind of teenagers growth phase oral care tooth liquid and preparation method thereof |
| CN111568826A (en) * | 2020-05-19 | 2020-08-25 | 四川涑爽医疗用品有限公司 | Oral care composition capable of resisting inflammation, relieving pain and preventing ulcer, oral care toothpaste and preparation method of oral care toothpaste |
| WO2021125632A1 (en) * | 2019-12-16 | 2021-06-24 | 주식회사 젠트리바이오 | External use composition comprising paeonol and panthenol or pharmaceutically acceptable salts thereof as active ingredients |
| CN113367372A (en) * | 2021-04-30 | 2021-09-10 | 河南中烟工业有限责任公司 | Heating cigarette additive with moisture slow-release function and preparation method and application thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103536451A (en) * | 2013-11-01 | 2014-01-29 | 广州市倩采化妆品有限公司 | Traditional Chinese medicine toothpaste and preparation method thereof |
| CN105796379A (en) * | 2016-05-06 | 2016-07-27 | 青岛蓝百合生物科技有限公司 | Water soluble chitosan oral care solution and preparation method thereof |
| CN108652998A (en) * | 2018-06-22 | 2018-10-16 | 中山遇美生物科技有限公司 | A kind of nursing tooth liquid and preparation method thereof improving oral inflammation |
| CN108652992A (en) * | 2018-06-22 | 2018-10-16 | 中山遇美生物科技有限公司 | A kind of canker sore repairs tooth liquid and preparation method thereof |
| CN108785115A (en) * | 2018-06-22 | 2018-11-13 | 中山遇美生物科技有限公司 | A kind of teenagers growth phase oral care tooth liquid and preparation method thereof |
| WO2021125632A1 (en) * | 2019-12-16 | 2021-06-24 | 주식회사 젠트리바이오 | External use composition comprising paeonol and panthenol or pharmaceutically acceptable salts thereof as active ingredients |
| US11337942B2 (en) | 2019-12-16 | 2022-05-24 | Gentribio Inc. | External use composition comprising paeonol and panthenol or pharmaceutically acceptable salts thereof as active ingredients |
| CN111568826A (en) * | 2020-05-19 | 2020-08-25 | 四川涑爽医疗用品有限公司 | Oral care composition capable of resisting inflammation, relieving pain and preventing ulcer, oral care toothpaste and preparation method of oral care toothpaste |
| CN113367372A (en) * | 2021-04-30 | 2021-09-10 | 河南中烟工业有限责任公司 | Heating cigarette additive with moisture slow-release function and preparation method and application thereof |
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Application publication date: 20120711 |