KR101268338B1 - Compositions for enhancing oral health comprising salangane nest extracts as an active ingredient - Google Patents

Compositions for enhancing oral health comprising salangane nest extracts as an active ingredient Download PDF

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KR101268338B1
KR101268338B1 KR1020100086013A KR20100086013A KR101268338B1 KR 101268338 B1 KR101268338 B1 KR 101268338B1 KR 1020100086013 A KR1020100086013 A KR 1020100086013A KR 20100086013 A KR20100086013 A KR 20100086013A KR 101268338 B1 KR101268338 B1 KR 101268338B1
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parts
weight
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periodontal disease
sodium
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KR20120022423A (en
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서성수
서상원
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(주)해피콜
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

본 발명은 바다제비집으로부터 추출된 바다제비집 추출물을 유효성분으로 포함하며, 보조성분으로 알란토인클로로히드록시알루미늄, 알란토인, 트라낵사민산 또는 아미노카프록산을 함유하는 치주질환 예방, 치료 및 충치 예방용 조성물에 관한 것이다. 본 발명은 치주질환 발생 원인물질인 구강 내 미생물을 효과적으로 억제할 수 있는 바다제비집 추출물을 유효성분으로 함유한 치주질환 예방, 치료 및 충치 예방용 조성물을 제공하여 치주질환 발생의 원인을 근본적으로 억제하여 치주질환을 예방할 수 있다.The present invention comprises a bird's nest extract extracted from sea bird's nest as an active ingredient, a composition for preventing, treating and preventing tooth decay, containing allantoin chlorohydroxyaluminum, allantoin, tranaxamine acid or aminocaproxane as an auxiliary component. It is about. The present invention provides a composition for preventing and treating periodontal disease, which contains sea bird's nest extract that can effectively inhibit microorganisms in the oral cavity, which is the cause of periodontal disease, as an active ingredient, thereby fundamentally suppressing the cause of periodontal disease. Periodontal disease can be prevented.

Description

바다제비집 추출물을 유효성분으로 포함하는 구강위생 증진용 조성물 {COMPOSITIONS FOR ENHANCING ORAL HEALTH COMPRISING SALANGANE NEST EXTRACTS AS AN ACTIVE INGREDIENT}Composition for enhancing oral hygiene comprising sea bird's nest extract as active ingredient {COMPOSITIONS FOR ENHANCING ORAL HEALTH COMPRISING SALANGANE NEST EXTRACTS AS AN ACTIVE INGREDIENT}

본 발명은 치주질환 예방, 치료 및 충치 예방에 효과가 우수한 구강위생 증진용 조성물에 관한 것으로, 보다 상세하게는 바다제비집으로부터 추출된 바다제비집 추출물을 유효성분으로 포함하며, 보조성분으로 알란토인클로로히드록시알루미늄, 알란토인, 트라낵사민산 또는 아미노카프록산을 함유하는 구강위생 증진용 조성물에 관한 것이다.
The present invention relates to an oral hygiene-promoting composition having an excellent effect on preventing, treating and preventing tooth decay. More specifically, it comprises an extract of sea bird's nest extracted from sea bird's nest as an active ingredient, and allantoinchlorohydroxy as an auxiliary ingredient. The present invention relates to a composition for enhancing oral hygiene containing aluminum, allantoin, tranexamic acid or aminocaproxane.

구강의 조직에 나타나는 각종 구강질환은 구강에 존재하는 수많은 세균으로 구성된 치태(프라그)에 의해 야기되며, 이에 대한 임상적, 병리적 중요성은 많은 연구자에 의해 확인되었다.Various oral diseases in the tissues of the oral cavity are caused by plaque composed of numerous bacteria present in the oral cavity, and clinical and pathological significance thereof has been confirmed by many researchers.

구강미생물은 치아 표면에 치태를 형성하는데, 이 치태의 독성세균이나 이들이 생산한 독소가 치주조직 내로 침입하여 치은의 염증, 치조골의 파괴 및 감염을 일으키면 치주병이 되며, 또한, 이들 세균이 산(酸)을 생성하면 치아우식증의 원인이 된다. 이들 세균들 중 혐기성 그람음성세균의 독소 및 대사산물이 치주조직을 파괴하거나 면역계를 자극하여 치주질환을 유발한다. 이런 다양한 세균들은 치태를 형성하여 증식하기 때문에 치태의 형성을 효과적으로 억제하거나, 이미 형성된 치태를 효과적으로 제거하는 것이 중요하며, 이들의 대사산물에 의하여 야기되는 치주조직의 파괴 경로를 차단하는 것이 이러한 질환을 예방하는 좋은 방법이 된다. 따라서 최근에는 이러한 구강질환을 예방, 치료하기 위하여 다양한 약물들이 개발되고 있고, 이들은 적용한 구강위생 증진용 제품들이 다양하게 개발되고 있다.Oral microorganisms form plaque on the surface of the tooth, which becomes a periodontal disease when toxic bacteria or toxins produced by the plaque invade the periodontal tissue, causing inflammation of the gingiva, destruction of alveolar bone, and infection. Iii) is the cause of dental caries. Among these bacteria, toxins and metabolites of anaerobic Gram-negative bacteria destroy periodontal tissues or stimulate the immune system to cause periodontal disease. Because these various bacteria form and multiply plaque, it is important to effectively suppress the formation of plaque or to effectively remove plaque that has already been formed, and to block the path of destruction of the periodontal tissue caused by their metabolites. It is a good way to prevent it. Therefore, in recent years, various drugs have been developed to prevent and treat such oral diseases, and various products for promoting oral hygiene have been developed.

구강 내 미생물의 활성을 저하하는 성분으로는 알란토인클로로히드록시알루미늄, 알란토인, 트라낵사민산 또는 아미노카프록산 등이 일반적으로 사용되나, 이들 성분은 지속적인 구강미생물 억제 효과를 얻기 어려운 것으로 알려져 있다.As a component that lowers the activity of microorganisms in the oral cavity, allantoin chlorohydroxyaluminum, allantoin, tranexamic acid, or aminocaproxane is generally used, but these components are known to be difficult to obtain sustained oral microbial inhibitory effects.

한편, 바다제비집(연와)은 중국 남부를 비롯해 말레이 반도, 자바, 수마트라 등 동남아시아 여러 나라의 바다 주변의 산과 절벽에 사는 바다제비의 일종인 “금사연”이 목구멍 속의 침샘에서 끈적이는 분비물을 뱉어 내어 누에가 누에고치를 짓듯이 만들며, 산란기에 발달한 침샘으로부터 분비되는 타액을 굳혀 약 1 개월에 걸쳐 만든다.On the other hand, the sea bird's nest (Yanwa) is a kind of sea swallow that lives in the mountains and cliffs around the seas of South China, Malay Peninsula, Java, Sumatra, and other Southeast Asian countries. It is made like a cocoon, and the saliva secreted from the salivary glands developed during the spawning period is hardened and made for about one month.

이러한 바다제비집은 현지에서도 특별한 채취인에게만 채취를 허용할 만큼 엄중한 감시 하에 행해지며 연간 채취량도 제한되고 있어 귀중한 식재료로서 현재에도 귀하게 여겨지고 있다.The bird's nest is carried out under strict supervision so as to allow only special harvesters in the field, and the annual harvest is also limited.

바다제비집으로부터 추출한 추출물의 효능, 효과로는 항바이러스 작용, 미백효과 등이 있다. 각종 인플루엔자 바이러스에 대한 저해효과는 Antibiral Res.70(3) 140-146, 2006에 발표되었으며, 바이러스를 저해하는 효과를 가진 당쇄구조는 제52회 일본약학회(2005)에 발표되었다. Efficacy and effects of extracts extracted from sea bird's nest include antiviral and whitening effects. The inhibitory effect on various influenza viruses was published in Antibiral Res. 70 (3) 140-146, 2006, and the sugar chain structure with the virus-inhibiting effect was presented in the 52nd Japanese Pharmacy Society (2005).

본 발명자들은 상술한 구강위생 증진용 제품들의 종래 기술의 단점들을 개선시키기 위하여 구강미생물에 대한 바다제비집의 항균 및 살균작용을 이용하여 치주질환 발생의 원인을 근본적으로 억제하여 치주질환을 예방하고자 집중적인 연구를 수행하였으며, 그 결과 바다제비집 추출물을 유효성분으로 함유한 조성물은 종래의 구강용 위생 조성물에 비해 치주질환 발생 원인물질인 구강 내 미생물을 효과적으로 억제하며, 이러한 조성물은 인체에도 안전하다는 사실을 발견하고 본 발명을 완성하기에 이르렀다.
The present inventors focused on preventing the periodontal disease by fundamentally suppressing the cause of periodontal disease by using the antibacterial and bactericidal action of the sea bird's nest against oral microorganisms to improve the disadvantages of the prior art of the oral hygiene-promoting products described above. As a result, the composition containing the extract of sea bird's nest as an active ingredient effectively inhibits the microorganisms in the oral cavity, which is the cause of periodontal disease, compared to the conventional hygiene composition for oral cavity, and found that the composition is safe for human body. The present invention has been completed.

본 발명의 목적은 치주질환 발생의 원인을 근본적으로 억제하여 치주질환을 예방할 수 있는, 지속적인 구강미생물 억제 효과를 갖는 바다제비집 추출물을 유효성분으로 포함하는 구강위생 증진용 조성물을 제공하는 데 있다.
It is an object of the present invention to provide a composition for enhancing oral hygiene comprising a sea bird's nest extract having an effective oral microbial inhibitory effect, which can fundamentally suppress the cause of periodontal disease, thereby preventing periodontal disease.

상기 목적을 달성하기 위하여, 본 발명은 바다제비집으로부터 추출된 바다제비집 추출물을 유효성분으로 포함하며, 보조성분으로 알란토인클로로히드록시알루미늄, 알란토인, 트라낵사민산 또는 아미노카프록산을 포함하는 것을 특징으로 하는 치주질환 예방, 치료 및 충치 예방용 조성물을 제공한다.In order to achieve the above object, the present invention comprises a sea bird's nest extract extracted from the sea bird's nest as an active ingredient, characterized in that it comprises allantoin chlorohydroxyaluminum, allantoin, tranxaminic acid or aminocaproxane as an auxiliary component To provide a composition for preventing and treating periodontal disease and caries prevention.

본 발명에서는 일정 농도 이상의 시알산을 포함하는 바다제비집 추출물을 사용한다.In the present invention, the bird's nest extract containing sialic acid above a certain concentration is used.

본 발명의 일 실시형태에 있어서, 상기 바다제비집 추출물은 구강위생 증진용 조성물 100 중량부 기준으로 1~5 중량부로 포함되며, 구강위생 증진용 조성물 100 중량부 기준으로 2~5 중량부로 포함되는 것이 바람직하다.In one embodiment of the present invention, the sea bird's nest extract is included in 1 to 5 parts by weight based on 100 parts by weight of the composition for oral hygiene, it is included in 2 to 5 parts by weight based on 100 parts by weight of the composition for oral hygiene. desirable.

본 발명에 따른 구강위생 증진용 조성물은 연마제, 습윤제, 약효제, 결합제, 기포제, 방부제, 감미제, 향료, pH 조절제 및 증백제로 이루어진 군으로부터 선택된 1종 또는 2종 이상의 혼합물을 더 포함할 수 있다.
Oral hygiene-promoting composition according to the present invention may further comprise one or two or more mixtures selected from the group consisting of abrasives, wetting agents, medicinal agents, binders, foaming agents, preservatives, sweeteners, flavoring agents, pH adjusting agents and brighteners. .

본 발명은 종래의 구강용 위생 조성물에 비해 치주질환 발생 원인물질인 구강 내 미생물을 효과적으로 억제할 수 있는 바다제비집 추출물을 유효성분으로 함유한 구강위생 증진용 조성물을 제공함으로써, 치주질환 발생의 원인을 근본적으로 억제하여 치주질환을 예방할 수 있다.
The present invention provides an oral hygiene-promoting composition containing the sea bird's nest extract that can effectively inhibit microorganisms in the oral cavity, which is the causative agent of periodontal disease, compared to the conventional hygiene composition for oral cavity, thereby causing the occurrence of periodontal disease. By fundamentally inhibiting can prevent periodontal disease.

도 1은 본 발명에서 사용되는 바다제비집 추출물에 포함되는 시알산의 화학구조를 나타낸 도면이다.1 is a view showing the chemical structure of sialic acid contained in the sea bird's nest extract used in the present invention.

이하 본 발명에 따른 바다제비집 추출물을 유효성분으로 포함하는 구강위생 증진용 조성물을 제공한다.
Provided below is a composition for enhancing oral hygiene comprising sea bird's nest extract according to the present invention as an active ingredient.

본 발명에 따른 구강위생 증진용 조성물은 바다제비집 추출물을 유효성분을 포함한다.Oral hygiene-producing composition according to the present invention comprises a sea bird's nest extract active ingredient.

본 발명에서 사용하는 바다제비집 추출물은 바다제비집에 포함되는 시알산 농도를 지표로 선정된 바다제비집을 사용하여 얻어질 수 있다. 바다제비집 추출물에 포함된 시알산은 구강미생물 억제 효과를 가지며, 바다제비집 추출물에 포함되는 시알산의 화학구조는 첨부된 도 1과 같다.The bird's nest extract used in the present invention can be obtained using the bird's nest selected as an indicator of the sialic acid concentration contained in the bird's nest. The sialic acid contained in the bird's nest extract has an oral microbial inhibitory effect, and the chemical structure of the sialic acid included in the bird's nest extract is as shown in FIG. 1.

본 발명에서 사용되는 바다제비집 추출물은 상업적으로 구매할 수 있는 바다제비집 추출물을 사용하거나, 바다제비집에 대해 효소분해 공정을 수행한 후 세척하여 이물질을 제거한 후 겔화하여 액상으로 얻을 것을 사용할 수 있다.The bird's nest extract used in the present invention can be used commercially available sea bird's nest extract, or after performing the enzymatic decomposition process for the bird's nest to remove the foreign matter and gelled to obtain a liquid.

상기 바다제비집 추출물은 구강위생 증진용 조성물 100 중량부 기준으로 1~5 중량부로 포함될 수 있으며, 구강위생 증진용 조성물 100 중량부 기준으로 2~5 중량부로 포함되는 것이 치주질환 예방, 치료 효과면에 있어서 바람직하다.The sea bird's nest extract may be included in an amount of 1 to 5 parts by weight based on 100 parts by weight of the composition for promoting oral hygiene, 2 to 5 parts by weight based on 100 parts by weight of the composition for improving oral hygiene in terms of preventing and treating periodontal disease. It is preferable.

본 발명의 일 실시형태에 있어서, 본 발명에 따른 구강위생 증진용 조성물은 바다제비집 추출물을 유효성분으로 포함하며, 구강 내 미생물의 활성을 저해하는 성분인 알란토인클로로히드록시알루미늄, 알란토인, 트라낵사민산 또는 아미노카프록산을 보조성분으로 포함할 수 있다.In one embodiment of the present invention, the composition for promoting oral hygiene according to the present invention includes the extract of the sea bird's nest as an active ingredient, allantoin chlorohydroxyaluminum, allantoin, tranaxamine, which inhibits the activity of microorganisms in the oral cavity Acids or aminocaproxanes may be included as auxiliary components.

본 발명의 다른 실시형태에 있어서, 구강위생 증진용 조성물은 제형 및 사용 목적 등에 따라 연마제, 습윤제, 약효제, 결합제, 기포제, 방부제, 감미제, 향료, pH 조절제, 증백제 등을 추가적으로 포함할 수 있다.In another embodiment of the present invention, the composition for promoting oral hygiene may further include an abrasive, a humectant, a medicinal agent, a binder, a foaming agent, a preservative, a sweetening agent, a flavoring agent, a pH adjusting agent, a brightener, and the like, depending on the formulation and the purpose of use. .

상기 연마제로는 인산수소칼슘, 콜로이드성 이산화규소, 침강탄산칼슘, 함수알루미나, 카올린, 중조 등을 단독 또는 혼합하여 사용할 수 있으며, 구강위생 증진용 조성물 100 중량부 기준으로 20~90 중량부, 바람직하게는 30~80 중량부를 사용할 수 있다.The abrasive may be used alone or mixed with calcium hydrogen phosphate, colloidal silicon dioxide, precipitated calcium carbonate, hydrous alumina, kaolin, sodium bicarbonate, etc., 20 to 90 parts by weight, based on 100 parts by weight of the composition for promoting oral hygiene, preferably Preferably 30 to 80 parts by weight can be used.

상기 습윤제로는 글리세린, 솔비톨, 비결정성 솔비톨액, 프로필렌글리콜, 폴리에틸렌글리콜, 자일리톨 등을 단독 또는 혼합하여 사용할 수 있으며, 구강위생 증진용 조성물 100 중량부 기준으로 20~60 중량부를 사용할 수 있다. The humectant may be used alone or mixed with glycerin, sorbitol, amorphous sorbitol liquid, propylene glycol, polyethylene glycol, xylitol, and the like, and may be used in an amount of 20 to 60 parts by weight based on 100 parts by weight of the composition for promoting oral hygiene.

상기 결합제로는 카르복시메틸셀룰로오스 나트륨, 카르복시비닐폴리머, 알긴산나트륨, 덴탈타입실리카 등을 단독 또는 혼합하여 사용할 수 있으며 구강위생 증진용 조성물 100 중량부 기준으로 0.2~5 중량부를 사용할 수 있다.As the binder, carboxymethyl cellulose sodium, carboxyvinyl polymer, sodium alginate, dental type silica, or the like may be used alone or in combination, and 0.2 to 5 parts by weight based on 100 parts by weight of the composition for promoting oral hygiene.

상기 약효제로는 일불소인산나트륨, 글리세로인산칼슘 등을 단독 또는 혼합하여 사용할 수 있으며, 구강위생 증진용 조성물 100 중량부 기준으로 0.5~1 중량부 사용할 수 있다.The medicament may be used alone or in combination, such as sodium monofluorophosphate, calcium glycophosphate, 0.5 to 1 parts by weight based on 100 parts by weight of oral hygiene composition.

상기 기포제로는 라우릴황산나트륨, 라우릴사르코신산 나트륨, 소르비탄지방산에스테르 등을 단독 또는 혼합하여 사용할 수 있으며 구강위생 증진용 조성물 100 중량부 기준으로 2 중량부를 사용할 수 있다.The foaming agent may be used alone or in combination of sodium lauryl sulfate, sodium lauryl sarcosinate, sorbitan fatty acid ester, and the like, may be used 2 parts by weight based on 100 parts by weight of the composition for oral hygiene.

상기 감미제로는 에리스리톨, 사카린나트륨, 자일리톨, 후디아, 아스파탐 등을 단독 또는 혼합하여 사용할 수 있으며 구강위생 증진용 조성물 100 중량부 기준으로 0.05~0.4 중량부를 사용할 수 있다. The sweetener may be used alone or mixed with erythritol, sodium saccharin, xylitol, hoodia, aspartame and the like, and may be used in an amount of 0.05 to 0.4 parts by weight based on 100 parts by weight of the composition for promoting oral hygiene.

상기 방부제로는 안식향산나트륨, 파리옥시안식향프로필, 파라옥시안식향산메칠에스텔나트륨, 파라옥시안식향산프로필에스텔나트늄 등을 단독 또는 혼합하여 사용할 수 있으며 구강위생 증진용 조성물 100 중량부 기준으로 0.02~0.3 중량부를 사용할 수 있다.As the preservative, sodium benzoate, paroxybenzoic acid propyl, paraoxybenzoic acid sodium methyl ester, paraoxybenzoic acid propyl ethylene nitrate may be used alone or in combination, and 0.02 to 0.3 parts by weight based on 100 parts by weight of the composition for promoting oral hygiene. Can be used.

상기 pH 조절제로는 인산나트륨, 구연산나트륨 또는 주석산을 사용할 수 있으며 pH 5~8 정도인 것이 바람직하다.As the pH adjusting agent, sodium phosphate, sodium citrate or tartaric acid may be used, and a pH of about 5 to 8 is preferable.

상기 증백제로는 산화티탄을 사용할 수 있으며, 구강위생 증진용 조성물 100 중량부 기준으로 0.1~2 중량부를 사용할 수 있다.Titanium oxide may be used as the brightener, and 0.1 to 2 parts by weight may be used based on 100 parts by weight of the composition for promoting oral hygiene.

상술한 본 발명에 따른 구강위생 증진용 조성물은 치약, 구강 청정제, 츄잉껌 등의 제형으로 사용할 수 있으며 1일 사용량을 통상 사용하는 용량으로 통상 1일 1~3회 정도 사용할 수 있다.
Oral hygiene-promoting composition according to the present invention can be used in the formulation of toothpaste, mouthwash, chewing gum and the like and can be used usually about 1 to 3 times a day in a daily use amount.

이하, 본 발명의 바람직한 실시예를 상세히 설명한다.
Hereinafter, preferred embodiments of the present invention will be described in detail.

글리세린 3 g3 g of glycerin

카르복시메틸셀룰로오스 0.7 g0.7 g of carboxymethylcellulose

증류수 20.16 g20.16 g of distilled water

솔비톨 60 g60 g of sorbitol

실리카 5 g5 g of silica

건식 실리카 5 g5 g of dry silica

일불소인산나트륨 0.76 g0.76 g of sodium monofluorophosphate

폴리에틸렌글리콜-1500 2.5 gPolyethylene glycol-1500 2.5 g

자일리톨 0.2 gXylitol 0.2 g

사카린나트륨 0.1 g0.1 g sodium saccharin

방부제(danisol-M) 0.15 g 0.15 g of antiseptic (danisol-M)

알란토인클로로히드록시알루미늄 0.1 g0.1 g of allantoin chlorohydroxyaluminum

아미노카프론산 0.1 g0.1 g of aminocaproic acid

트라낵사민산 0.1 g0.1 g of tranthacamine acid

에리스리톨 0.03 g Erythritol 0.03 g

글리세로인산칼슘 0.5 g0.5 g calcium phosphate

소디움 라우릴 설페이트 2 g2 g of sodium lauryl sulfate

향료(F-90943) 0.1 g0.1 g of fragrances (F-90943)

바다제비집 추출물 1 gSea bird's nest extract 1 g

상기 성분들을 사용하여 일반적인 치약 조성물의 제법을 사용하여 치약 조성물을 제조하였다.
Toothpaste compositions were prepared using the formulation of common toothpaste compositions using these ingredients.

글리세린 3 g3 g of glycerin

카르복시메틸셀룰로오스 0.55 g0.55 g of carboxymethylcellulose

증류수 10.86 g10.86 g of distilled water

솔비톨 60 g60 g of sorbitol

실리카(73K) 5 g5 g of silica (73K)

함수규산(43K) 10 gHydrous silicic acid (43K) 10 g

일불소인산나트륨 0.76 g0.76 g of sodium monofluorophosphate

폴리에틸렌글리콜-1500 2.5 gPolyethylene glycol-1500 2.5 g

자일리톨 0.2 gXylitol 0.2 g

사카린나트륨 0.1 g0.1 g sodium saccharin

방부제(danisol-M) 0.15 g 0.15 g of antiseptic (danisol-M)

알란토인클로로히드록시알루미늄 0.1 g0.1 g of allantoin chlorohydroxyaluminum

아미노카프론산 0.1 g0.1 g of aminocaproic acid

트라낵사민산(0.1%) 0.1 g0.1 g of tranacsamonic acid (0.1%)

에리스리톨 0.03 g Erythritol 0.03 g

글리세로인산칼슘 0.5 g0.5 g calcium phosphate

TiO2(0.3%) 1 g TiO 2 (0.3%) 1 g

소디움 라우릴 설페이트 2 g2 g of sodium lauryl sulfate

향료(F-90943) 0.1 g0.1 g of fragrances (F-90943)

바다제비집 추출물 1 gSea bird's nest extract 1 g

상기 성분들을 사용하여 일반적인 치약 조성물의 제법을 사용하여 치약 조성물을 제조하였다.
Toothpaste compositions were prepared using the formulation of common toothpaste compositions using these ingredients.

글리세린 3 g3 g of glycerin

카르복시메틸셀룰로오스 0.5 g0.5 g of carboxymethylcellulose

증류수 16.56 g16.56 g of distilled water

솔비톨 60 g60 g of sorbitol

건식실리카 4 g4 g of dry silica

함수규산(43K) 4 gFunctional silicic acid (43K) 4 g

일불소인산나트륨 0.76 g0.76 g of sodium monofluorophosphate

폴리에틸렌글리콜-1500 2.5 gPolyethylene glycol-1500 2.5 g

자일리톨 0.2 gXylitol 0.2 g

사카린나트륨 0.1 g0.1 g sodium saccharin

방부제(danisol-M) 0.15 g 0.15 g of antiseptic (danisol-M)

알란토인클로로히드록시알루미늄 0.1 g0.1 g of allantoin chlorohydroxyaluminum

아미노카프론산 0.1 g0.1 g of aminocaproic acid

트라낵사민산(0.1%) 0.1 g0.1 g of tranacsamonic acid (0.1%)

에리스리톨(0.03%) 0.03 g 0.03 g of erythritol (0.03%)

글리세로인산칼슘(0.1%) 0.5 g TiO2(0.3%) 1 g Calcium Glycerophosphate (0.1%) 0.5 g TiO 2 (0.3%) 1 g

소디움 라우릴 설페이트 2 g2 g of sodium lauryl sulfate

향료(F-90943) 0.1 g0.1 g of fragrances (F-90943)

바다제비집 추출물 1 gSea bird's nest extract 1 g

상기 성분들을 사용하여 일반적인 치약 조성물의 제법을 사용하여 치약 조성물을 제조하였다.Toothpaste compositions were prepared using the formulation of common toothpaste compositions using these ingredients.

상기 실시예 1 내지 3에 따라 제조된 치약 조성물에 대하여, 치주질환을 발생시키는 대표적인 구강 내 미생물인 스트렙토코커스 뮤탄스와 포피로모나스 진지발리스에 대한 항균 활성을 측정한 결과, 매우 우수한 항균 활성을 나타냄을 확인하였다.
In the toothpaste composition prepared according to Examples 1 to 3, the antimicrobial activity of the representative oral microorganisms Streptococcus mutans and Popiromonas gingivalis, which cause periodontal disease, was measured. It was confirmed.

이상 본 발명을 바람직한 실시예에 대해서 설명하지만, 본 발명은 상술한 특정 실시예에 한정되는 것은 아니며, 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자라면 그 기술적 사상을 벗어나지 않고 다양하게 변형 실시할 수 있을 것이다. 따라서 본 발명의 권리범위는 특정 실시예가 아니라, 첨부된 특허청구범위에 의해 정해지는 것으로 해석되어야 한다.While the present invention has been described with reference to exemplary embodiments, it is to be understood that the present invention is not limited to the disclosed exemplary embodiments, but many variations and modifications may be made without departing from the scope of the present invention. You can do it. Accordingly, the scope of the present invention should be construed as being determined not by the specific embodiments but by the appended claims.

Claims (7)

바다제비집으로부터 추출된 바다제비집 추출물을 유효성분으로 포함하며, 보조성분으로 알란토인클로로히드록시알루미늄, 알란토인, 트라낵사민산 또는 아미노카프록산을 포함하되,
상기 바다제비집 추출물은 시알산을 포함하는 것을 특징으로 하는 치주질환 예방, 치료 및 충치 예방용 조성물.
It includes the extract of the tern's nest as an active ingredient, and includes allantoin chlorohydroxyaluminum, allantoin, tranxaminic acid or aminocaproxane as an auxiliary component,
The sea bird's nest extract is a composition for preventing, treating and decaying periodontal disease, characterized in that it comprises sialic acid.
삭제delete 청구항 1에 있어서,
상기 바다제비집 추출물은 치주질환 예방, 치료 및 충치 예방용 조성물 100 중량부 기준으로 1~5 중량부 포함되는 것을 특징으로 하는 치주질환 예방, 치료 및 충치 예방용 조성물.
The method according to claim 1,
The sea bird's nest extract is a periodontal disease prevention, treatment and cavities prevention composition for periodontal disease prevention, treatment and cavities, characterized in that it comprises 1 to 5 parts by weight based on 100 parts by weight.
청구항 3에 있어서,
상기 바다제비집 추출물은 치주질환 예방, 치료 및 충치 예방용 조성물 100 중량부 기준으로 2~5 중량부 포함되는 것을 특징으로 하는 치주질환 예방, 치료 및 충치 예방용 조성물.
The method according to claim 3,
The sea bird's nest extract is a periodontal disease prevention, treatment and cavities prevention composition for periodontal disease prevention, treatment and cavities, characterized in that it comprises 2 to 5 parts by weight based on 100 parts by weight.
청구항 1에 있어서,
상기 치주질환 예방, 치료 및 충치 예방용 조성물은 연마제, 습윤제, 약효제, 결합제, 기포제, 방부제, 감미제, 향료, pH 조절제 및 증백제로 이루어진 군으로부터 선택된 1종 또는 2종 이상의 혼합물을 더 포함하는 것을 특징으로 하는 치주질환 예방, 치료 및 충치 예방용 조성물.
The method according to claim 1,
The periodontal disease prevention, treatment and cavities prevention composition further comprises one or a mixture of two or more selected from the group consisting of abrasives, wetting agents, medicinal agents, binders, foaming agents, preservatives, sweeteners, flavoring agents, pH adjusting agents and brighteners. Periodontal disease prevention, treatment and caries prevention composition, characterized in that.
청구항 5에 있어서,
상기 연마제로는 인산수소칼슘, 콜로이드성 이산화규소, 침강탄산칼슘, 함수알루미나 및 카올린 중조로 이루어진 군으로부터 선택된 1종 또는 2종 이상의 혼합물을 조성물 100 중량부 기준으로 20~90 중량부 사용하며, 상기 습윤제로는 글리세린, 솔비톨, 비결정성 솔비톨액, 프로필렌글리콜, 폴리에틸렌글리콜 및 자일리톨으로 이루어진 군으로부터 선택된 1종 또는 2종 이상의 혼합물을 조성물 100 중량부 기준으로 20~60 중량부 사용하며, 상기 결합제로는 카르복시메틸셀룰로오스 나트륨, 카르복시비닐폴리머, 알긴산나트륨 및 덴탈타입실리카로 이루어진 군으로부터 선택된 1종 또는 2종 이상의 혼합물을 조성물 100 중량부 기준으로 0.2~5 중량부 사용하며, 상기 약효제로는 일불소인산나트륨 또는 글리세로인산칼슘을 조성물 100 중량부 기준으로 0.5~1 중량부 사용하는 것을 특징으로 하는 치주질환 예방, 치료 및 충치 예방용 조성물.
The method according to claim 5,
The abrasive may be 20 to 90 parts by weight based on 100 parts by weight of one or more mixtures selected from the group consisting of calcium hydrogen phosphate, colloidal silicon dioxide, precipitated calcium carbonate, hydrous alumina and kaolin sodium bicarbonate. As the wetting agent, 20 to 60 parts by weight of one or two or more mixtures selected from the group consisting of glycerin, sorbitol, amorphous sorbitol liquid, propylene glycol, polyethylene glycol and xylitol based on 100 parts by weight of the composition is used. One or two or more mixtures selected from the group consisting of sodium carboxymethyl cellulose, carboxyvinyl polymer, sodium alginate and dental type silica are used in an amount of 0.2 to 5 parts by weight based on 100 parts by weight of the composition, and the pharmacological agent is sodium monofluorophosphate. Or 0.5 to 1 weight of glycerophosphate based on 100 parts by weight of the composition Periodontal disease prevention, treatment and cavities prevention composition, characterized in that the use.
청구항 5에 있어서,
상기 기포제로는 라우릴황산나트륨, 라우릴사르코신산 나트륨 및 소르비탄지방산에스테르로 이루어진 군으로부터 선택된 1종 또는 2종 이상의 혼합물을 조성물 100 중량부 기준으로 2 중량부 사용하며, 상기 감미제로는 에리스리톨, 사카린나트륨, 자일리톨, 후디아 및 아스파탐으로 이루어진 군으로부터 선택된 1종 또는 2종 이상의 혼합물을 조성물 100 중량부 기준으로 0.05~0.4 중량부 사용하며, 상기 방부제로는 안식향산나트륨, 파리옥시안식향프로필, 파라옥시안식향산메칠에스텔나트륨 및 파라옥시안식향산프로필에스텔나트늄으로 이루어진 군으로부터 선택된 1종 또는 2종 이상의 혼합물을 조성물 100 중량부 기준으로 0.02~0.3 중량부 사용하며, 상기 pH 조절제로는 pH 5~8인 인산나트륨, 구연산나트륨 또는 주석산을 사용하며, 상기 증백제로는 산화티탄을 조성물 100 중량부 기준으로 0.1~2 중량부 사용하는 것을 특징으로 하는 치주질환 예방, 치료 및 충치 예방용 조성물.The method according to claim 5,
As the foaming agent, 2 parts by weight of one or two or more mixtures selected from the group consisting of sodium lauryl sulfate, sodium lauryl sarcosinate and sorbitan fatty acid esters based on 100 parts by weight of the composition, and the sweetener is erythritol, saccharin One or a mixture of two or more selected from the group consisting of sodium, xylitol, hoodia and aspartame is used in an amount of 0.05 to 0.4 parts by weight based on 100 parts by weight of the composition, and the preservatives include sodium benzoate, paroxybenzoic acid propyl and paraoxybenzoic acid methyl. One or two or more mixtures selected from the group consisting of sodium sodium and parapropyl benzoate are used in an amount of 0.02 to 0.3 parts by weight based on 100 parts by weight of the composition, and the pH adjusting agent may include sodium phosphate having a pH of 5 to 8, Sodium citrate or tartaric acid is used, and the brightener is tea oxide Periodontal disease prevention, treatment, and prevention of dental caries composition which is characterized by using 0.1 to 2 parts by weight to 100 parts by weight of composition basis.
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