CN105796379A - Water soluble chitosan oral care solution and preparation method thereof - Google Patents
Water soluble chitosan oral care solution and preparation method thereof Download PDFInfo
- Publication number
- CN105796379A CN105796379A CN201610294025.6A CN201610294025A CN105796379A CN 105796379 A CN105796379 A CN 105796379A CN 201610294025 A CN201610294025 A CN 201610294025A CN 105796379 A CN105796379 A CN 105796379A
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- Prior art keywords
- chitosan
- collutory
- extract
- solution
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The invention is suitable for the technical field of oral care, and provides an oral care solution. The oral care solution comprises water soluble chitosan, xylitol and allantoin, wherein the water soluble chitosan is selected from one or more of sulfonation chitosan, sulfonation chitin, succinyl chitosan, chitosan quaternary ammonium salt, glucosamine, N-acetylglucosamine, chitosan oligosaccharide, chitin oligose, carboxymethyl chitin, carboxymethyl chitosan, hydroxypropyl chitosan, hydroxypropyl chitin, hydroxyethyl chitosan, hydroxyethyl chitin and chitosan oligosaccharide.
Description
Technical field
The invention belongs to oral care techniques field, be specifically related to a kind of water-soluble chitosan oral nursing liquid,
Its preparation method and application thereof.
Background technology
Along with the development of economic society, the improvement of living standards of the people, the diet structure of people is also occurring
Change, corresponding all kinds of oral problem are more and more universal.
Dental caries is the oral health issue that current era people are more occurred frequently, and particularly baby, child and green grass or young crops is few
Year, existing fluorinated anti-caries product (toothpaste, collutory, oral nursing liquid etc.) makes for infant
Leave a question open with having inconvenience and safety.
Gingival atrophy is the key factor causing loss of tooth, and the most effective for gingival atrophy at present
Prevention product.
Periodontal disease is the oral disease that a class generally exists, other kinds oral disease, wound and corresponding
The pain produced after operation and treatment brings many puzzlements and inconvenience to the life of people, is the most such as provided that
Easy to use, effect significantly care product for tooth and periodontal will have significant commercial value.
Summary of the invention
The purpose of the embodiment of the present invention is to provide a kind of water-soluble chitosan oral nursing liquid, it is intended to solve existing
There is the problem that oral cavity and periodontal care product effect in technology are undesirable.
The above-mentioned purpose of the present invention is achieved in that a kind of collutory, containing following composition: water soluble shells
Polysaccharide, xylitol and allantoin, wherein said water-soluble chitosan is selected from sulfonated chitosan, sulfonated
Chitin, succinyl-chitosan, chitosan quaternary ammonium salt, glucosamine, 2-Acetamido-2-deoxy-D-glucose, shell
Oligosaccharide, chitin oligosaccharide, carboxymethyl chitin, carboxymethyl chitosan, hydroxypropyl chitosan, hydroxypropyl carapace
One or more in element, hydroxyethyl chitosan, ethoxyl chitin and oligo-chitosan.
The present invention also provides for the preparation method of a kind of collutory, comprises the following steps:
The aqueous solution of S1 preparation water-soluble chitosan, adds xylitol and allantoin, stirring, sterilizing, obtains
First solution；
S2 makes the temperature of described first solution be reduced to less than 40 DEG C, adds potassium sorbate, polysorbas20, stirs
Mix, obtain the second solution；
S3 makes described second solution temperature be down to less than 25 DEG C, adds the ethanol solution of Mentholum.
The present invention provide collutory have antibacterial, remove dental plaque, prevent and suppress dental caries continue develop
Effect, and easy to use, safety.The collutory of the present invention can also be effectively improved gingiva tissue cell simultaneously
Growing environment, strengthen gingival cell energy for growth, delay gingival atrophy, moreover it is possible to effectively suppression causes periodontitis
All kinds of microorganism species growth, prevention periodontal disease generation.
Detailed description of the invention
In order to make the technical problem to be solved in the present invention, technical scheme and beneficial effect clearer, with
Under in conjunction with the embodiments, the present invention is further elaborated.Should be appreciated that described herein specifically
Embodiment only in order to explain the present invention, is not intended to limit the present invention.
Embodiments providing a kind of oral care composition containing water-soluble chitosan, it has pre-
Anti-caries, consolidate the effects such as gingiva, pre-preventing parodontitis and analgesia.Said composition can be liquid, paste or
Block.Said composition is to show as collutory during liquid, and paste can be toothpaste, bulk can be buccal tablet or
Similar state.
The oral care composition of the embodiment of the present invention contains water-soluble chitosan, xylitol and allantoin.Shell
Polysaccharide (chitosan) is the product that the chitin (chitin) being widely present by nature obtains through deacetylation
Thing, chemical name is Chitosan (1-4)-2-amino-B-D glucose.Water-soluble in the embodiment of the present invention
Property chitosan selected from sulfonated chitosan, sulfonated chitin, succinyl-chitosan, chitosan quaternary ammonium salt,
Glucosamine, 2-Acetamido-2-deoxy-D-glucose, oligochitosan, chitin oligosaccharide, carboxymethyl chitin, carboxymethyl
Chitosan, hydroxypropyl chitosan, Chitofilmer, hydroxyethyl chitosan, ethoxyl chitin and oligomeric
One or more in chitosan.
Its consumption it is interpreted as this area when should be understood that and technical scheme does not limits concrete consumption
Conventional effective dose known to technical staff, the concrete consumption used in optimal technical scheme can obtain relatively
Good action effect.
Specifically, the content of the water-soluble chitosan that the oral care composition of the embodiment of the present invention contains is with weight
Amount percentage calculation is 0.1-5%, and the content of xylitol is 0.1-5%, and the content of allantoin is 0.01-5%.
Should be understood that unless otherwise specified, the content of the composition otherwise used in the present invention is all with percentage by weight
Meter.
Allantoin (Allantoin), also referred to as Allantoin, Allantoin, urea groups sea
Because of, Allantoin, being a kind of hydantoin derivatives, it is widely present in tobacco seed, Radix Betae, little
Fructus Hordei Germinatus, allantois Ye Deng animals and plants circle.
The oral care composition provided in the embodiment of the present invention, such as collutory, utilize water-soluble chitosan
With the combination of allantoin, periodontal tissue's convergence can be made tooth and periodontal surface to be formed protection simultaneously.Logical
Cross addition xylitol so that good mouthfeel, it is to avoid sense of discomfort, can extend the use time, in particular for
Teenager and child so that the periodontal nursing role cycle is shorter.
Preferably, the oral care composition of the embodiment of the present invention also can contain Mentholum, and this Mentholum is with second
The form of alcoholic solution adds, and its content is preferably 0.01-0.5%.
Mentholum is to extract the leaf from Herba Menthae and stem to obtain, and it acts on skin or mucosa, has refrigerant antipruritic
Effect, can alleviate the pain of periodontal, promotes the healing of wound.
Preferably, the oral care composition of the embodiment of the present invention also can contain glycerol, and its content is preferably
0.1-3.5%.The effect of glycerol is so that the mixing of various material is more uniform, and composition is the most more stable.
Preferably, the oral care composition of the embodiment of the present invention also can contain potassium sorbate, and its content is preferred
For 0.01-2%.Potassium sorbate makes composition more stable, can improve the shelf-life of collutory.
Preferably, the oral care composition of the embodiment of the present invention also can contain soil temperature 20, and its content is preferred
For 0.01-2%.Soil temperature 20 is a kind of surfactant, contributes to removing dental plaque, makes oral cavity cleaning,
Effective active composition can be helped to infiltrate into below mucosa simultaneously.
Should be understood that the impurity produced in raw material preparation process should not be considered as constituting the oral cavity of the present invention
The effective ingredient of care composition.
It is highly preferred that the oral care composition of the embodiment of the present invention also can contain various plants extract, bag
Include but be not limited to Flos Lonicerae extract, Flos Chrysanthemi extract, camomile extract, extract from pine needles etc..
According to preferred embodiment, Flos Lonicerae extract content in oral care composition is 0.1-5%,
And obtain Flos Lonicerae extract by water or ethanol extraction.
According to preferred embodiment, Flos Chrysanthemi extract content in oral care composition is 0.1-5%, and
Flos Lonicerae extract is obtained by water or ethanol extraction.
Flos Matricariae chamomillae is feverfew, is again Anthemis nobilis, Matricaria recutita.Its extract can alleviate inflammation
Disease and pain symptom.According to preferred embodiment, camomile extract content in oral care composition is
0.1-5%, and preferably water extract.
Extract from pine needles can promote inflammation healing, protects periodontal health, and it is preferably obtained by ethanol extraction,
And the content in oral care composition is preferably 0.1-5%.
On the other hand, embodiments provide the preparation method of a kind of collutory, comprise the following steps:
S1 obtains the aqueous solution of water-soluble chitosan, removes insoluble impurities in solution and adds in this aqueous solution
Enter xylitol and allantoin, stirring, sterilizing, obtain the first solution；
S2 makes the temperature of described first solution be reduced to about 40 DEG C, adds potassium sorbate, polysorbas20, stirs
Mix, obtain the second solution；
S3 makes described second solution temperature be down to less than 25 DEG C, is slowly added to the ethanol solution of Mentholum.
The component mentioned in above preferred embodiment all can i.e. add in step S3 to keep at normal temperatures
Biologic activity, obtains good result.
Further, the above-mentioned preparation method of the present invention may also include the step that collutory carries out filtration sterilization
Suddenly, this filtration can utilize the filter membrane of 0.45 μm to carry out in aseptic super-clean bench, it is also possible to uses 0.22 μm
Filter membrane carry out in super-clean bench.
" below " that the present invention uses is understood to include this numeral.Such as, less than 25 DEG C should include
25℃.Terminology used in the present invention " multiple " is interpreted as more than or equal to 2 kinds.
Below by way of specific embodiment, the present invention is further described.
Embodiment 1
According to the following weight various materials of acquisition:
Concrete operations are as follows:
Hydroxyethyl chitosan is dissolved in 80mL pure water, removes insoluble impurities in solution, to this aqueous solution
Middle addition xylitol and allantoin, stirring, high temperature sterilize (121 DEG C, 20 minutes), obtain the first solution.
The temperature making described first solution cools, and when temperature is down to about 40 DEG C, adds potassium sorbate,
Stirring, obtains the second solution.Described second solution is made to continue cooling, when temperature is down to about 25 DEG C, slowly
Adding the ethanol solution of Mentholum, addition axenic purification water is to 100g, with 0.45 μm membrane filtration.
Gained collutory is supplied to the experimenter suffering from periodontitis, using normal saline as comparison, after one week
Symptom is significantly alleviated, but matched group is alleviated inconspicuous.
Embodiment 2
According to the following weight various materials of acquisition:
Preparation method is similar to embodiment 1, and wherein carboxymethyl chitosan, glycerol and xylitol are simultaneously introduced,
Soil temperature 20 and potassium sorbate are simultaneously introduced.
Test experiments proves that the collutory of this embodiment has significantly effect for the alleviation of periodontitis symptom, with
Time can reduce dental plaque formation (using normal saline as comparison).
Embodiment 3
According to the following weight various materials of preparation:
Wherein Flos Lonicerae extract is to be placed in water Flos Lonicerae to boil five minutes, and cooled and filtered obtains.
Its preparation method is similar to embodiment 1, and wherein chitin oligosaccharide, glycerol and xylitol are simultaneously introduced, soil
Temperature 20 and potassium sorbate are simultaneously introduced, and Mentholum and Flos Lonicerae extract are simultaneously introduced.
Embodiment 4
According to the following weight various materials of preparation:
Wherein Flos Lonicerae extract is Flos Lonicerae to be placed in 75% ethanol solution immersion within 2 hours, obtain.Flos Chrysanthemi
Extract is to be soaked in Flos Chrysanthemi in 50% ethanol solution to continue to obtain for 3 hours.
Its preparation method is similar to embodiment 1, and the most sulfonated chitin and xylitol are simultaneously introduced, soil temperature
20 add when cooling for the first time, and Mentholum, Flos Lonicerae extract and Flos Chrysanthemi extract are when being down to room temperature
Add.
Embodiment 5
According to the following weight various materials of preparation:
Wherein Flos Lonicerae extract is to be placed in water Flos Lonicerae to boil five minutes, and cooled and filtered obtains.Ocean is sweet
Chrysanthemum extract is to be placed in water Flos Matricariae chamomillae to boil ten minutes, and cooled and filtered obtains.Extract from pine needles is by pine
Pin is placed in 75% alcoholic solution immersion and obtains for 2 hours.
Its preparation method is similar to embodiment 1, and wherein glucosamine, glycerol and xylitol are at high temperature sterilize
Adding, potassium sorbate adds after cooling for the first time, and remaining composition adds when being down to room temperature before.
Test proves that the collutory of the present embodiment can significantly alleviate oral inflammation relative to matched group, reduces tooth bacterium
Speckle.
The oral care composition of the present invention has formula simply as can be seen here, the significant advantage of nursing efficacy.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all at this
Any amendment, equivalent and the improvement etc. made within bright spirit and principle, should be included in the present invention
Protection domain within.
Claims (7)
1. a collutory, containing following composition: water-soluble chitosan, xylitol and allantoin, wherein
Described water-soluble chitosan is to gather selected from sulfonated chitosan, sulfonated chitin, succinyl-chitosan, shell
Sugar quaternary ammonium salt, glucosamine, 2-Acetamido-2-deoxy-D-glucose, oligochitosan, chitin oligosaccharide, carboxymethyl crusta
Element, carboxymethyl chitosan, hydroxypropyl chitosan, Chitofilmer, hydroxyethyl chitosan, ethoxy first
One or more in shell element and oligo-chitosan.
2. collutory as claimed in claim 1, it is characterised in that described collutory is possibly together with Mentholum.
3. collutory as claimed in claim 1, it is characterised in that described collutory is possibly together with glycerol.
4. collutory as claimed in claim 1, it is characterised in that described collutory is possibly together with sorbic acid
Potassium and/or soil temperature 20.
5. collutory as claimed in claim 1, it is characterised in that described collutory is possibly together with Flos Lonicerae
Extract, Flos Chrysanthemi extract, at least one in ocean glycosides chrysanthemum extract and extract from pine needles.
6. a preparation method for collutory, comprises the following steps:
The aqueous solution of S1 preparation water-soluble chitosan, adds xylitol and allantoin, stirring, sterilizing, obtains
First solution；
S2 makes the temperature of described first solution be reduced to less than 40 DEG C, adds potassium sorbate and/or polysorbas20,
Stirring, obtains the second solution；
S3 makes described second solution temperature be down to less than 25 DEG C, adds the ethanol solution of Mentholum.
7. preparation method as claimed in claim 6, it is characterised in that further comprising the steps of in S3:
Add Flos Lonicerae extract, Flos Chrysanthemi extract, at least one in ocean glycosides chrysanthemum extract and extract from pine needles.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610294025.6A CN105796379A (en) | 2016-05-06 | 2016-05-06 | Water soluble chitosan oral care solution and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610294025.6A CN105796379A (en) | 2016-05-06 | 2016-05-06 | Water soluble chitosan oral care solution and preparation method thereof |
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| CN105796379A true CN105796379A (en) | 2016-07-27 |
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| CN201610294025.6A Pending CN105796379A (en) | 2016-05-06 | 2016-05-06 | Water soluble chitosan oral care solution and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106726691A (en) * | 2016-12-30 | 2017-05-31 | 泉州亚林新材料科技有限公司 | A kind of shitosan mouthwash and preparation method thereof |
| CN107595725A (en) * | 2017-11-13 | 2018-01-19 | 青岛明药堂医疗股份有限公司 | One kind smears tea flavour mouthwash and preparation method thereof |
| CN111358723A (en) * | 2020-04-15 | 2020-07-03 | 武汉森澜生物科技有限公司 | Mouthwash and preparation method thereof |
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Address after: 266107 No. 36, East Shan Shan Road, Chengyang District, Qingdao, Shandong Applicant after: Qingdao Tong doctor Biotechnology Co., Ltd. Address before: 266107 No. 36, East Shan Shan Road, Chengyang District, Qingdao, Shandong Applicant before: QINGDAO LANBAIHE BIOTECHNOLOGY CO., LTD. |
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