CN103405483A - Oral ulcer membrane - Google Patents
Oral ulcer membrane Download PDFInfo
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- CN103405483A CN103405483A CN2013103498353A CN201310349835A CN103405483A CN 103405483 A CN103405483 A CN 103405483A CN 2013103498353 A CN2013103498353 A CN 2013103498353A CN 201310349835 A CN201310349835 A CN 201310349835A CN 103405483 A CN103405483 A CN 103405483A
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Abstract
The invention relates to the field of medical instrument, and specifically provides an oral ulcer membrane. The membrane is in a three-layer structure. An upper layer and a lower layer comprise components of water-soluble chitosan and a humectant; and an interface layer comprises components of water-soluble chitosan and sesame oil. During the process of promoting healing of oral ulcer, the membrane can continuously provide nutrients for the oral ulcer, so as to enhance curative effect.
Description
Technical field
The present invention relates to medical instruments field, concrete is a kind of KOUQIANG KUIYANG MO.
Background technology
Oral ulcer is a kind of common oral mucosa disease, is a kind of shallow and little, circular or avette ulcer, the high and very easily recurrence of sickness rate.
Now be used for the treatment of the oral ulcer dosage form and mainly contain tablet, liniment, membrane.Tablet is harder, larger to the wound surface mechanical stimulus while sticking, and can not use by the ulcer surface size.The liniment consumption is few, and active ingredient is few, weak curative effect.Membrane is softer, and less to the wound surface zest, preparation method is simple.
Chinese invention patent (publication number is CN1879682A and CN1927208A) discloses polyvinyl alcohol and the Western medicine active ingredient is mixed with membrane treatment oral ulcer.That this membrane carrier materials polyvinyl alcohol or mixture do not have is antibacterial, promote the effect such as healing, and polyvinyl alcohol film skin affinity is bad.The Western medicine active ingredient can have side effects to human body.
Water-soluble chitosan has good biocompatibility, film property, viscosity, and certain antibiotic, antiinflammatory, anastalsis are arranged, and also can promote regeneration, reparation and the healing of wound tissue.The existing product that adopts chitosan to prepare KOUQIANG KUIYANG MO on the market, as beneficial moral nation KOUQIANG KUIYANG MO, this film can not provide nutrient substance to KOUQIANG KUIYANG MO.
Summary of the invention
The object of the present invention is to provide a kind of KOUQIANG KUIYANG MO, mainly solve the existing technical problem of above-mentioned prior art, it,, in the process that promotes the oral ulcer healing, can constantly provide nutrient substance-Oleum Sesami to oral ulcer, increases curative effect.
For solving the problems of the technologies described above, the present invention is achieved in that
A kind of KOUQIANG KUIYANG MO is characterized in that: it is comprised of three-decker, and wherein upper and lower two-layer composition is water-soluble chitosan and wetting agent, and the composition in intermediate layer is water-soluble chitosan and Oleum Sesami.
Described KOUQIANG KUIYANG MO is characterized in that: described water-soluble chitosan is any one or the multiple mixture in carboxymethyl chitosan, chitosan quaternary ammonium salt, hydroxyethyl chitosan.
Described KOUQIANG KUIYANG MO is characterized in that: in described upper and lower double-layer structure, comprise any one or several mixture in collagen protein, serum albumin, fish protein.
Described KOUQIANG KUIYANG MO is characterized in that: described wetting agent is any one or a few mixture in glycerol, propylene glycol, sorbitol.
Described KOUQIANG KUIYANG MO is characterized in that: upper and lower two membranes thickness is 0.05mm-0.15mm.
Described KOUQIANG KUIYANG MO is characterized in that: water in intermediate layer soluble chitosan Oleum Sesami blend film thickness is 0.15mm-0.7mm.
Described KOUQIANG KUIYANG MO is characterized in that: in raw materials, the proportion that Oleum Sesami accounts for whole KOUQIANG KUIYANG MO is 1%-40%.
Described KOUQIANG KUIYANG MO is characterized in that: in raw materials, and water-soluble chitosan 1-50g, Oleum Sesami 1-100g, tween 80 0.5-10g, glycerol 1-100g, distilled water 50-1000g.
The invention has the beneficial effects as follows:
1) can antibacterial, promotion ulcer healing.
When 2) film dissolves, slowly discharge Oleum Sesami, the effect of performance Oleum Sesami.
3) fuel load is large, better efficacy.
4) film softness, affinity is good, good biocompatibility.
The accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
The specific embodiment
Refer to Fig. 1, the invention discloses a kind of KOUQIANG KUIYANG MO.As shown in the figure: it is comprised of three-decker, and wherein upper and lower two-layer 1 composition is water-soluble chitosan and wetting agent, and the composition in intermediate layer 2 is water-soluble chitosan and Oleum Sesami.
Water-soluble chitosan described in the present invention is any one or the multiple mixture in carboxymethyl chitosan, chitosan quaternary ammonium salt, hydroxyethyl chitosan.
In upper and lower double-layer structure described in the present invention, comprise any one or several mixture in collagen protein, serum albumin, fish protein.
Wetting agent described in the present invention is any one or a few mixture in glycerol, propylene glycol, sorbitol.
In the present invention, upper and lower two-layer 1 thickness is 0.05mm-0.15mm.Intermediate layer 2 water-soluble chitosan Oleum Sesami blend film thickness are 0.15mm-0.7mm.
In raw materials of the present invention, the proportion that Oleum Sesami accounts for whole KOUQIANG KUIYANG MO is 1%-40%.Concrete: water-soluble chitosan 1-50g, Oleum Sesami 1-100g, tween 80 0.5-10g, glycerol 1-100g, distilled water 50-1000g.
The invention will be further described below in conjunction with embodiment
Embodiment 1
Take off the row raw material: 6g hydroxyethyl chitosan, 2g glycerol, 0.5g tween 80,5g Oleum Sesami and purified water.
Make as follows the KOUQIANG KUIYANG MO product:
A: by after 1g hydroxyethyl chitosan, glycerol and purified water stirring and evenly mixing, casting film-forming is prepared into understructure.
B: by after 5g hydroxyethyl chitosan, tween 80, Oleum Sesami and purified water stirring and evenly mixing, continue casting film-forming and form intermediate structure on prepared understructure.
C: continue repeating step A on intermediate structure, obtain superstructure.
D: the KOUQIANG KUIYANG MO that will make is cut into the size of regulation, this KOUQIANG KUIYANG MO.
Embodiment 2
Take off the row raw material: 10g chitosan quaternary ammonium salt, 2g sorbitol, 1.5g tween 80,25g Oleum Sesami and purified water.
Make as follows the KOUQIANG KUIYANG MO product:
A: by after 3g chitosan quaternary ammonium salt, glycerol and purified water stirring and evenly mixing, casting film-forming is prepared into understructure.
B: by after 7g chitosan quaternary ammonium salt, tween 80, Oleum Sesami and purified water stirring and evenly mixing, continue casting film-forming and form intermediate structure on prepared understructure.
C: continue repeating step A on intermediate structure, obtain superstructure.
D: the KOUQIANG KUIYANG MO that will make is cut into the size of regulation, this KOUQIANG KUIYANG MO.
Embodiment 3
Take off the row raw material: 17g carboxymethyl chitosan, 5g propylene glycol, 2g collagen, 1.5g tween 80,50g Oleum Sesami and purified water.
Make as follows the KOUQIANG KUIYANG MO product:
A: by after 7g chitosan quaternary ammonium salt, glycerol and purified water stirring and evenly mixing, casting film-forming is prepared into understructure.
B: by after 10g chitosan quaternary ammonium salt, tween 80, Oleum Sesami and purified water stirring and evenly mixing, continue casting film-forming and form intermediate structure on prepared understructure.
C: continue repeating step A on intermediate structure, obtain superstructure.
D: the KOUQIANG KUIYANG MO that will make is cut into the size of regulation, this KOUQIANG KUIYANG MO.
Be only preferred embodiment of the present invention in sum, not be used for limiting practical range of the present invention.Be that all equivalences of doing according to the content of the present patent application the scope of the claims change and modify, all should be technology category of the present invention.
Claims (8)
1. KOUQIANG KUIYANG MO, it is characterized in that: it is comprised of three-decker, and wherein upper and lower two-layer composition is water-soluble chitosan and wetting agent, and the composition in intermediate layer is water-soluble chitosan and Oleum Sesami.
2. KOUQIANG KUIYANG MO according to claim 1 is characterized in that: described water-soluble chitosan is any one or the multiple mixture in carboxymethyl chitosan, chitosan quaternary ammonium salt, hydroxyethyl chitosan.
3. KOUQIANG KUIYANG MO according to claim 1 is characterized in that: in described upper and lower double-layer structure, comprise any one or several mixture in collagen protein, serum albumin, fish protein.
4. KOUQIANG KUIYANG MO according to claim 1, it is characterized in that: described wetting agent is any one or a few mixture in glycerol, propylene glycol, sorbitol.
5. KOUQIANG KUIYANG MO according to claim 1, it is characterized in that: upper and lower two membranes thickness is 0.05mm-0.15mm.
6. KOUQIANG KUIYANG MO according to claim 1, it is characterized in that: water in intermediate layer soluble chitosan Oleum Sesami blend film thickness is 0.15mm-0.7mm.
7. KOUQIANG KUIYANG MO according to claim 1, it is characterized in that: in raw materials, the proportion that Oleum Sesami accounts for whole KOUQIANG KUIYANG MO is 1%-40%.
8. KOUQIANG KUIYANG MO according to claim 1 is characterized in that: in raw materials, and water-soluble chitosan 1-50g, Oleum Sesami 1-100g, tween 80 0.5-10g, glycerol 1-100g, distilled water 50-1000g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310349835.3A CN103405483B (en) | 2013-08-13 | 2013-08-13 | A kind of KOUQIANG KUIYANG MO |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310349835.3A CN103405483B (en) | 2013-08-13 | 2013-08-13 | A kind of KOUQIANG KUIYANG MO |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103405483A true CN103405483A (en) | 2013-11-27 |
| CN103405483B CN103405483B (en) | 2016-03-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201310349835.3A Active CN103405483B (en) | 2013-08-13 | 2013-08-13 | A kind of KOUQIANG KUIYANG MO |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105107013A (en) * | 2015-09-09 | 2015-12-02 | 上海美宝生命科技有限公司 | High oil content biological composite membrane and preparation method thereof |
| CN105477688A (en) * | 2015-12-08 | 2016-04-13 | 安徽天瑞塑业有限公司 | Brush bristle improving oral ulcers and preparation process thereof |
| CN105796379A (en) * | 2016-05-06 | 2016-07-27 | 青岛蓝百合生物科技有限公司 | Water soluble chitosan oral care solution and preparation method thereof |
| CN108785496A (en) * | 2018-09-03 | 2018-11-13 | 解智强 | A kind of canker sore sustained release pad pasting and preparation method thereof |
| CN110664651A (en) * | 2019-11-16 | 2020-01-10 | 许帅辉 | Composition for treating oral mucosa repair and preparation method thereof |
| CN111249328A (en) * | 2020-03-13 | 2020-06-09 | 河南护理职业学院 | Compound oral ulcer film and preparation method thereof |
| CN115737605A (en) * | 2022-11-24 | 2023-03-07 | 杭州归领医疗器械有限公司 | Oral ulcer membrane with sandwich structure and lasting viscosity and preparation method thereof |
Citations (4)
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|---|---|---|---|---|
| EP1917982A1 (en) * | 2006-11-06 | 2008-05-07 | Lohmann & Rauscher GmbH & Co. KG | Product for the treatment of inflammation, bruises and/or ulcers in the oral area and the use of such a product |
| KR20120125317A (en) * | 2010-01-28 | 2012-11-14 | 네이처스 래버러토리 리미티드 | Propolis and process for the treatment thereof and end products formed therefrom |
| CN102813957A (en) * | 2012-09-14 | 2012-12-12 | 上海白衣缘生物工程有限公司 | Biological membrane which promotes healing and preparation method thereof |
| CN202908940U (en) * | 2012-09-14 | 2013-05-01 | 上海白衣缘生物工程有限公司 | Biofilm compound dressing |
-
2013
- 2013-08-13 CN CN201310349835.3A patent/CN103405483B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1917982A1 (en) * | 2006-11-06 | 2008-05-07 | Lohmann & Rauscher GmbH & Co. KG | Product for the treatment of inflammation, bruises and/or ulcers in the oral area and the use of such a product |
| KR20120125317A (en) * | 2010-01-28 | 2012-11-14 | 네이처스 래버러토리 리미티드 | Propolis and process for the treatment thereof and end products formed therefrom |
| CN102813957A (en) * | 2012-09-14 | 2012-12-12 | 上海白衣缘生物工程有限公司 | Biological membrane which promotes healing and preparation method thereof |
| CN202908940U (en) * | 2012-09-14 | 2013-05-01 | 上海白衣缘生物工程有限公司 | Biofilm compound dressing |
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| 裴红娜: "C-P-CA 复合膜作为口腔溃疡治疗材料的研究", 《中国优秀硕士学位论文全文数据库（电子期刊）医药卫生科技辑》, no. 3, 31 December 2009 (2009-12-31), pages 080 - 20 * |
| 郭新嵩: "《现代家庭保健必读-实用偏方秘方大全》", 31 January 2005, article "处方6", pages: 449 * |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105107013A (en) * | 2015-09-09 | 2015-12-02 | 上海美宝生命科技有限公司 | High oil content biological composite membrane and preparation method thereof |
| CN105107013B (en) * | 2015-09-09 | 2017-11-24 | 上海美宝生命科技有限公司 | A kind of floorboard with high oil content biological composite membrane and preparation method thereof |
| CN105477688A (en) * | 2015-12-08 | 2016-04-13 | 安徽天瑞塑业有限公司 | Brush bristle improving oral ulcers and preparation process thereof |
| CN105796379A (en) * | 2016-05-06 | 2016-07-27 | 青岛蓝百合生物科技有限公司 | Water soluble chitosan oral care solution and preparation method thereof |
| CN108785496A (en) * | 2018-09-03 | 2018-11-13 | 解智强 | A kind of canker sore sustained release pad pasting and preparation method thereof |
| CN110664651A (en) * | 2019-11-16 | 2020-01-10 | 许帅辉 | Composition for treating oral mucosa repair and preparation method thereof |
| CN111249328A (en) * | 2020-03-13 | 2020-06-09 | 河南护理职业学院 | Compound oral ulcer film and preparation method thereof |
| CN111249328B (en) * | 2020-03-13 | 2021-06-25 | 河南护理职业学院 | Compound oral ulcer film and preparation method thereof |
| CN115737605A (en) * | 2022-11-24 | 2023-03-07 | 杭州归领医疗器械有限公司 | Oral ulcer membrane with sandwich structure and lasting viscosity and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103405483B (en) | 2016-03-23 |
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