CN105107013A - High oil content biological composite membrane and preparation method thereof - Google Patents
High oil content biological composite membrane and preparation method thereof Download PDFInfo
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- CN105107013A CN105107013A CN201510569600.4A CN201510569600A CN105107013A CN 105107013 A CN105107013 A CN 105107013A CN 201510569600 A CN201510569600 A CN 201510569600A CN 105107013 A CN105107013 A CN 105107013A
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Abstract
The invention relates to a high oil content biological composite membrane and a preparation method thereof. The biological composite membrane contains water-soluble biopolymer materials and oily substances, wherein the content (W/W) of the oily substances is 20-95% of the composition. The high oil content biological composite membrane is an ideal medical dressing and has a double-layer membrane structure. The membrane has certain flexibility and strength, the outer-layer membrane can absorb and then gradually dissolve wound seepage, and thus the inner-layer membrane can release the oily substances capable of promoting wound healing and simultaneously can absorb the wound seepage to form gel; adhesion with a wound surface can be avoided, the dressing change is convenient, secondary damage can not be caused, and physiologic wetting of the wound can be kept; and the high oil content biological composite membrane has antibacterial and anti-inflammatory effects.
Description
Technical field
The invention belongs to field of medicaments, particularly a kind of biological composite membrane and preparation method thereof of floorboard with high oil content.
Background technology
Body surface wound comprises burn and scald, scratch, mechanical injury, operative incision, skin donor site and various skin ulcers etc., how wound repairing, wound healing, and improves function and the outward appearance of skin after healing, is the Important Problems of surgical field.At present, wound dressing has the wide market demand, and existing dressing can not meet the requirement of patient, and therefore, the good biocompatibility of research and development a new generation, biodegradable, having the body surface wound dressing that tissue induces performance, is very necessary.
Desirable dressing should possess following functions: (1) makes wound surface keep moist environment, is beneficial to wound healing; (2) wound is made to keep stationary temperature (37 DEG C); (3) can effectively absorb wound surface exudate, reduce and infect; (4) not only there is good permeability, and effectively can intercept the invasion of antibacterial and effective particle; (5) can not stick together with wound, in order to avoid cause secondary damage when removing dressing; (6) there is antibacterial, antiinflammation, easy to use.
Along with development that is social and medical science, there is the dressing first-selection that bioactive functional medical dressing will become treatment wound surface, the focus of the wherein research and development by becoming desirable medical dressing such as medical bio macromolecular material.Oily substance, especially Oleum sesami is material Chinese tradition being used for the treatment of scald, burn.In Oleum sesami, Multiple components all has agglutinant function, and the unsaturated fatty acids such as oleic acid wherein, linoleic acid have hydrophobicity, Castor Oil mucosa, and isolated external irritant, eases the pain, impel wound healing; The compositions such as sesamol wherein, sitosterol, sesamin and brown material have extremely strong non-oxidizability, promote fissional regeneration function; Wherein vitamin E has antioxidation, relevant with muscle nutrition, can maintain the permeability of blood capillary, improve surrounding loop; In addition, Oleum sesami is nontoxic, wide material sources, low price, applies clinically conveniently, safety, effectively.
Application number is 201210341386.3 disclose a kind of promoting healing biomembrane and preparation method thereof, its be by chitosan derivative solution and Oleum sesami blended after, carry out ionomer, then drying and forming-film obtains.In the biomembrane obtained by the method, the content of Oleum sesami is extremely low, is only the 1%-6% of chitosan derivative solution; Because the chitosan derivatives film of nonpolar Oleum sesami and polarity is incompatible, the even so Oleum sesami of low content, is also easy to the surface of emersion film, causes the instability of product, the further reduction of oil content, uses the problems such as inconvenient.
Summary of the invention
The object of the present invention is to provide biological composite membrane of a kind of floorboard with high oil content and preparation method thereof, solve the technical problem existing for above-mentioned prior art, it is a kind of desirable medical dressing, and it has two-layer film configuration.This film has certain pliability and intensity, and outer membrane can dissolve after absorbing wound exudate gradually, thus makes inner layer film while release can promote the oily substance of wound healing, also can absorb wound exudate and form gel; And can not stick together with wound surface, change dressings convenient and can not secondary damage be produced, the physiology of wound can be kept moistening; And have antibacterial and anti-inflammation functions.
For achieving the above object, technical scheme of the present invention is:
A kind of floorboard with high oil content biological composite membrane, is characterized in that: such biological composite membrane contains water-soluble biological macromolecular material and oily substance, wherein the content (W/W) of oily substance accounts for the 20%-95% of its composition.
Described floorboard with high oil content biological composite membrane, is characterized in that: described oily substance is pure and the vegetable oil after extracting medicine, one or several the mixture in animal oil.
Described floorboard with high oil content biological composite membrane, is characterized in that: described water-soluble biological macromolecular material is the mixture of one or more in water-soluble chitosan, sodium alginate, collagen protein, polyvinyl alcohol.
Described high oil-containing biological composite membrane, is characterized in that: described water-soluble chitosan is one or several the mixture in carboxymethyl chitosan, hydroxypropyl chitosan, hydroxyethyl chitosan, chitosan quaternary ammonium salt.
Described high oil-containing biological composite membrane, is characterized in that: containing antibiotic substance in described oily substance, comprise the mixture of one or more in nanometer silver, silver ion, zinc ion.
A preparation method for floorboard with high oil content biological composite membrane as above, is characterized in that: the method includes the steps of:
1) carry out water-soluble biological macromolecular material to dissolve that to be mixed with content in every 100ml water be the solution of 2 ~ 15g, be stirred to and dissolve completely;
2) by obtained solution by including but not limited to the method film forming of curtain coating, lyophilizing, replacement dewatering;
3) by step 2) obtained by biopolymer film immerse abundant swelling rear taking-up in oily substance;
4) as step 1) method configuration water-soluble biological macromolecular solution 2 ~ 50ml, room temperature dries, sealing, sterilizing preserve.
A preparation method for floorboard with high oil content biological composite membrane as above, is characterized in that: the method includes the steps of:
1) carry out water-soluble biological macromolecular material to dissolve that to be mixed with content in every 100ml water be the solution of 2 ~ 15g, be stirred to and dissolve completely;
2) by obtained solution by including but not limited to the method film forming of curtain coating, lyophilizing, replacement dewatering;
3) by step 2) obtained by biopolymer film immerse abundant swelling rear taking-up in oily substance;
4) the biopolymer powder of 1 ~ 20g is covered in the surperficial surrounding of the biopolymer film of above-mentioned swelling oily substance.
Described oily substance, as one or more in Oleum sesami, Oleum Ricini, olive oil, preferred Oleum sesami.
Described water-soluble biological macromolecular material is one or more in water-soluble chitosan, sodium alginate, collagen protein, polyvinyl alcohol, preferred water soluble chitosan.
Described water-soluble chitosan is one or more in carboxymethyl chitosan, hydroxypropyl chitosan, hydroxyethyl chitosan, chitosan quaternary ammonium salt, preferred carboxymethyl chitosan.
Preparation method of the present invention, its moulding mechanism is:
By first film forming, again Oleum sesami is utilized the swelling character of water-soluble biological polymeric membrane, swelling for nonpolar oily substance entering in the internal structure of the water-soluble biological polymeric membrane of polarity is gone, and swelling after, the film of this floorboard with high oil content surrounding spraying on biological macromolecular solution film forming again.The oil content of this film can reach the 20-95% of whole membrane component, and protects due to outer field film, and oil due to the reason emersion surface of polarity, can not cause the problems such as the instability of product.
Floorboard with high oil content biological composite membrane prepared by the inventive method, its advantage is:
1, wound physiology moist environment can be kept, be beneficial to wound healing.
2, can effectively absorb wound surface exudate, reduce and infect; Make wound surface keep moist environment, be beneficial to wound healing.
3, not only there is good permeability, and effectively can intercept the invasion of antibacterial and effective particle.
Can not stick together with wound, in order to avoid cause secondary damage when 4, removing dressing.
5, there is antibacterial, antiinflammation, easy to use.
Detailed description of the invention
Now further describe the present invention in conjunction with following Examples, the following example is intended to illustrate preparation method of the present invention further, and these embodiments do not limit the present invention in any way the scope of accompanying claims.
Embodiment 1
1) take carboxymethyl chitosan 2g, be added in the purified water of 100ml, be stirred to and dissolve completely;
2) obtained solution is clamp-oned in dehydrated alcohol carry out replacement dewatering film forming;
3) by step 2) obtained by Carboxymethyl-chitosan Membranes immerse abundant swelling rear taking-up in Oleum sesami;
4) by the carboxymethyl chitosan powder of the surperficial surrounding spraying 2g of the Carboxymethyl-chitosan Membranes containing Oleum sesami of gained, room temperature dries, and sealing, sterilizing are preserved.
Embodiment 2
1) take carboxymethyl chitosan 5g, be added in the purified water of 100ml, be stirred to and dissolve completely;
2) obtained solution is at room temperature dried film forming;
3) by step 2) obtained by Carboxymethyl-chitosan Membranes immerse abundant swelling rear taking-up in Oleum sesami;
4) by the surperficial surrounding spraying of the Carboxymethyl-chitosan Membranes containing Oleum sesami of gained as step 1) 10ml carboxymethyl chitosan solution obtained by method, room temperature dries, sealing, sterilizing preservation.
Embodiment 3
1) take carboxymethyl chitosan 5g, be added in the purified water of 100ml, be stirred to and dissolve completely;
2) film forming is done in the at room temperature lyophilizing of obtained solution;
3) by step 2) obtained by Carboxymethyl-chitosan Membranes immerse abundant swelling rear taking-up in Oleum sesami;
4) by the surperficial surrounding spraying of the Carboxymethyl-chitosan Membranes containing Oleum sesami of gained as step 1) 10ml carboxymethyl chitosan solution obtained by method, room temperature dries, sealing, sterilizing preservation.
Embodiment 4
1) take sodium alginate 4g, be added in the purified water of 100ml, be stirred to and dissolve completely;
2) obtained solution is clamp-oned in acetone carry out replacement dewatering film forming;
3) by step 2) obtained by sodium alginate film immerse abundant swelling rear taking-up in Oleum sesami;
4) by the surperficial surrounding spraying 2g sodium alginate powder of the sodium alginate film containing Oleum sesami of gained, room temperature dries, and sealing, sterilizing are preserved.
Embodiment 5
1) weighing polyvinyl alcohol 15g, is added in the purified water of 100ml, is stirred to and dissolves completely;
2) obtained solution is at room temperature dried film forming;
3) by step 2) obtained by polyvinyl alcohol film immerse abundant swelling rear taking-up in Oleum sesami;
4) by the surperficial surrounding spraying of the polyvinyl alcohol film containing Oleum sesami of gained as step 1) 20ml poly-vinyl alcohol solution obtained by method, room temperature dries, sealing, sterilizing preservation.
The determination test of oil content
1, test apparatus
1) analytical balance (precision is 0.0001g)
2) calorstat
3) thermostat water bath
4) separatory funnel of 100ml
5) exsiccator
6) neutral qualitative filter paper
2, test reagent
1) petroleum ether
2) anhydrous chlorides of rase sodium
3) (1+1) sulphuric acid
4) sodium chloride
3, test procedure
1) take sample and be designated as m1, be dissolved in the deionized water of 100ml, all be transferred in separatory funnel after dissolving, and add 5g sodium chloride, the sulphuric acid of (1+1) of 1.5ml, the petroleum ether of 4ml, shake well 3min, stratification, released by aqueous phase, organic facies proceeds in the conical flask of 100ml;
2) in petroleum ether extraction liquid, add appropriate anhydrous sodium sulfate (to no longer luming), after adding a cover, place more than 0.5h, to dewater;
3) filter with the qualitative filter paper crossed through petroleum ether in advance, (beaker weight is designated as m in drying in the beaker of constant weight to collect filtrate
2), with a small amount of petroleum ether conical flask, sodium sulfate and filter paper, washing liquid is incorporated in beaker;
4) by beaker as in the water-bath of 65 ± 5 DEG C, steam petroleum ether, the calorstat being placed in 65 ± 5 DEG C after near dry again dries 1h, then puts into exsiccator and cools 30min, weighs and is designated as m
3.
4, experiment calculation
In sample, the computing formula of oil content is:
Wherein: m1 is the weight (g) of sample;
M2 is the weight (g) of beaker;
M3 is the weight (g) that beaker refuels.
5, result of the test
5.1 embodiments 1
5.2 embodiments 2
5.3 embodiments 3
5.4 embodiments 4
5.5 embodiments 5
Be only preferred embodiment of the present invention in sum, be not used for limiting practical range of the present invention.Namely all equivalences done according to the content of the present patent application the scope of the claims change and modify, and all should be technology category of the present invention.
Claims (7)
1. a floorboard with high oil content biological composite membrane, is characterized in that: such biological composite membrane contains water-soluble biological macromolecular material and oily substance, and wherein the content (W/W) of oily substance accounts for the 20%-95% of its composition.
2. floorboard with high oil content biological composite membrane according to claim 1, is characterized in that: described oily substance is pure and the vegetable oil after extracting medicine, one or several the mixture in animal oil.
3. floorboard with high oil content biological composite membrane according to claim 1, is characterized in that: described water-soluble biological macromolecular material is the mixture of one or more in water-soluble chitosan, sodium alginate, collagen protein, polyvinyl alcohol.
4. high oil-containing biological composite membrane according to claim 3, is characterized in that: described water-soluble chitosan is one or several the mixture in carboxymethyl chitosan, hydroxypropyl chitosan, hydroxyethyl chitosan, chitosan quaternary ammonium salt.
5. high oil-containing biological composite membrane according to claim 1, is characterized in that: containing antibiotic substance in described oily substance, comprise the mixture of one or more in nanometer silver, silver ion, zinc ion.
6. a preparation method for the floorboard with high oil content biological composite membrane as described in claim 1 or 2 or 3 or 4 or 5, is characterized in that: the method includes the steps of:
1) carry out water-soluble biological macromolecular material to dissolve that to be mixed with content in every 100ml water be the solution of 2 ~ 15g, be stirred to and dissolve completely;
2) by obtained solution by including but not limited to the method film forming of curtain coating, lyophilizing, replacement dewatering;
3) by step 2) obtained by biopolymer film immerse abundant swelling rear taking-up in oily substance;
4) as step 1) method configuration water-soluble biological macromolecular solution 2 ~ 50ml, room temperature dries, sealing, sterilizing preserve.
7. a preparation method for the floorboard with high oil content biological composite membrane as described in claim 1 or 2 or 3 or 4 or 5, is characterized in that: the method includes the steps of:
1) carry out water-soluble biological macromolecular material to dissolve that to be mixed with content in every 100ml water be the solution of 2 ~ 15g, be stirred to and dissolve completely;
2) by obtained solution by including but not limited to the method film forming of curtain coating, lyophilizing, replacement dewatering;
3) by step 2) obtained by biopolymer film immerse abundant swelling rear taking-up in oily substance;
4) the biopolymer powder of 1 ~ 20g is covered in the surperficial surrounding of the biopolymer film of above-mentioned swelling oily substance.
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| CN201510569600.4A CN105107013B (en) | 2015-09-09 | 2015-09-09 | A kind of floorboard with high oil content biological composite membrane and preparation method thereof |
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| CN201510569600.4A CN105107013B (en) | 2015-09-09 | 2015-09-09 | A kind of floorboard with high oil content biological composite membrane and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107362385A (en) * | 2017-03-29 | 2017-11-21 | 浙江医鼎医用敷料有限公司 | A kind of medical dressing and preparation method and preparation facilities with biological nutritve function |
| CN111714705A (en) * | 2020-06-12 | 2020-09-29 | 福建纽伯尔生物科技有限公司 | Suturable biomembrane, preparation method and application |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107362385A (en) * | 2017-03-29 | 2017-11-21 | 浙江医鼎医用敷料有限公司 | A kind of medical dressing and preparation method and preparation facilities with biological nutritve function |
| CN111714705A (en) * | 2020-06-12 | 2020-09-29 | 福建纽伯尔生物科技有限公司 | Suturable biomembrane, preparation method and application |
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| CN105107013B (en) | 2017-11-24 |
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