CN103285419A - Method for preparing medical wound repair material - Google Patents
Method for preparing medical wound repair material Download PDFInfo
- Publication number
- CN103285419A CN103285419A CN2012100453233A CN201210045323A CN103285419A CN 103285419 A CN103285419 A CN 103285419A CN 2012100453233 A CN2012100453233 A CN 2012100453233A CN 201210045323 A CN201210045323 A CN 201210045323A CN 103285419 A CN103285419 A CN 103285419A
- Authority
- CN
- China
- Prior art keywords
- chitin
- cream
- cera flava
- medical
- wound repair
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The invention provides a method for preparing a medical wound repair material. The method comprises the following steps: soaking 1 to 5 parts of chitin in 90 to 95 parts of sesame oil for 20 to 24 hours; heating the sesame oil added with the chitin to 100 DEG C by using slow fire and maintaining for 20 to 30 minutes; filtering chitin sediment, and remaining the miscible substance of the chitin and the sesame oil; adding 1 to 5 parts of beewax into the miscible substance of the chitin and the sesame oil and mixing uniformly to fully melt the beewax; cooling the mixture to obtain the miscible substance of chitin beewax cream; and soaking medical non-woven gauze into the miscible substance of the chitin beewax cream, wherein the medical non-woven gauze stained with the miscible substance of the chitin beewax cream is the medical wound repair material. Compared with the prior art, the method for preparing the medical wound repair material has the advantages of 1, moisture retention property of a hydrophobic film; 2, partial bacteriostatic and nutritional properties; and 3, painless in dressing change.
Description
Technical field
The present invention relates to field of medical products, specifically is a kind of method for preparing medical wound repair material.
Background technology
Chitin is as a kind of natural macromolecular material; have another name called chitin, chitin; after acetylation, be called chitosan; it is a kind of linear aminopolysaccharide of keeping and protecting crustacean and microorganism body; extensively be present in the wing or shell that saves sufficient animal, also be present in fungus and algae and starve in the cell wall.There is the scholar to prove that by experiment chitin makes impaired biological physical ability induce special cells abroad, promotes wound healing, have antiinflammatory, hemostasis, analgesic property.Have and experimental results show that carapace have the effect of prevention tissue adhesion, minimizing cicatrization.
In developed country such as American-European-Japanese, chitin material and derivant thereof are widely used in the medical sanitary field.As the operation suture thread of du pont company, need not remove after the recovery; With containing the solution coatings of chitin/chitosan, the non-woven after the coating is through containing the solution-treated of alkali with non-weaving cloth for US Patent No. 197322, is present in that chitosan can slowly be absorbed by bioengineered tissue in the non-weaving cloth, thereby promotes the cell growth.The medical materials made from chitin such as immunopotentiating agent, absorbable sutures, artificial skin and wound dressing have been developed at present.Domestic have chitin is prepared into the aqueous solution saliva liquid film forming of living, or be prepared into powder or spun-laced nonwoven fabric etc. and be used for medical wound.
The Cera Flava sweet in the mouth, slightly warm in nature has astringent therapy to hold back effects such as skin ulcer, granulation promoting pain relieving.Han Xu etc. find by animal experimental observation, and the ointment made from Cera Flava can obviously improve the new capillary vessel quantity of chronic skin wound surface, improves the wound surface microcirculation, the acceleration of tissue repair process.Cera Flava can form the hyaline membrane of one deck yellow at wound surface, and wound surface is played protection and moistening effect, has reduced the chance of bacterial infection.Modern pharmacological research confirms that Oleum sesami is cool in nature sweet, and skin moistening itself has the effect of removing toxic substances and promoting granulation, can provide tissue growth needed nutritional labeling, improves the chronic wound negative nitrogen balance, promotes wound healing.Oil gauze is applied ointment or plaster can effectively prevent the evaporation of moisture behind the wound surface in wrapping, make wound surface keep certain humidity, be under the condition that is similar to physiological environment, get rid of slough by undamaged liquefaction, be conducive to the epithelial growth of wound surface, reduce cicatrization.Simultaneously, if be coated with wound surface outward with Oleum sesami, can reduce oozing out of wound surface, prevention infection reduces gauze and skin wound adhesion, is conducive to the healing of wound surface.
But above material has certain weak point, and the moisture retention that has is not enough, and the bacteriostasis that has is not enough, and the Nutrition to wound that has is poor, has influenced the healing of wound.
Summary of the invention
At the deficiencies in the prior art, the purpose of this invention is to provide a kind of method for preparing medical wound repair material, can effectively promote the healing of surface wound, for the application of clinical dressing provides more selection.
The present invention solves the problems of the technologies described above the technical scheme that adopts to be:
A kind of method for preparing medical wound repair material with soaking 20-24 hour in 90～95 parts of Oleum sesami of 1～5 part of chitin adding, is heated to 100 ℃ with slow fire, keeps 20-30 minute; Elimination chitin sediment, the immiscible material of reservation chitin and Oleum sesami; The immiscible material of described chitin and Oleum sesami is equipped with 1～5 part of Cera Flava, and mix homogeneously all melts Cera Flava, obtains chitin Cera Flava cream immiscible material after the cooling; Medical nonwoven gauze is immersed described chitin Cera Flava cream immiscible material, and the medical nonwoven gauze that speckles with described chitin Cera Flava cream immiscible material namely is described medical wound repair material.
The present invention compared with prior art has the following advantages: 1, the moisture retention of hydrophobic film-forming, 2, local antibacterial and trophism, 3, the painless property of changing dressings.
The specific embodiment
Below in conjunction with specific embodiment the technical scheme among the present invention is clearly and completely described.
Embodiment 1
To soak 24 hours in 94 parts of Oleum sesami of 1 part of chitin adding, slow fire is heated to 100 ℃, keeps 30 minutes; Elimination chitin sediment, the immiscible material of reservation chitin and Oleum sesami; The immiscible material of described chitin and Oleum sesami is equipped with 5 parts of Cera Flavas, and mix homogeneously all melts Cera Flava, obtains chitin Cera Flava cream immiscible material (being pale brown color) after the cooling.Then medical nonwoven gauze is immersed described chitin Cera Flava cream immiscible material, the medical nonwoven gauze that speckles with described chitin Cera Flava cream immiscible material namely is described medical wound repair material, and packing is used cobalt-60 radiosterilization.
Embodiment 2
To soak 22 hours in 94 parts of Oleum sesami of 3 parts of chitins addings, slow fire is heated to 100 ℃, keeps 28 minutes; Elimination chitin sediment, the immiscible material of reservation chitin and Oleum sesami; The immiscible material of described chitin and Oleum sesami is equipped with 3 parts of Cera Flavas, and mix homogeneously all melts Cera Flava, obtains chitin Cera Flava cream immiscible material (being pale brown color) after the cooling.Then medical nonwoven gauze is immersed described chitin Cera Flava cream immiscible material, the medical nonwoven gauze that speckles with described chitin Cera Flava cream immiscible material namely is described medical wound repair material, and packing is used cobalt-60 radiosterilization.
Embodiment 3
To soak 23 hours in 90 parts of Oleum sesami of 5 parts of chitins addings, slow fire is heated to 100 ℃, keeps 25 minutes; Elimination chitin sediment, the immiscible material of reservation chitin and Oleum sesami; The immiscible material of described chitin and Oleum sesami is equipped with 5 parts of Cera Flavas, and mix homogeneously all melts Cera Flava, obtains chitin Cera Flava cream immiscible material (being pale brown color) after the cooling.Then medical nonwoven gauze is immersed described chitin Cera Flava cream immiscible material, the medical nonwoven gauze that speckles with described chitin Cera Flava cream immiscible material namely is described medical wound repair material, and packing is used cobalt-60 radiosterilization.
The embodiment of the invention takes full advantage of the hydrophobicity of Cera Flava, Oleum sesami and the film property of chitin, can fully keep wound surface to be in the environment that is similar to physiological status, has the moisture retention of hydrophobic film-forming, meets " wet union theory " that Winter proposes.Oleum sesami contains abundant plant sterol, oleic acid, inferior acid etc., and for the wound surface basal cell provides nutrient substance, the regeneration of active cell has local trophism; Chitin has local antiinflammatory, bacteriostasis, and chitin Cera Flava cream wound healing rate is increased, and has the effect that promotes wound healing.The outer compress material of chitin Cera Flava has hydrophobicity and film forming moisture retention, the not sticking wound of dressing, and the secondary damage of no wound, the patient is not bitterly when changing dressings.
Use the chitin Cera Flava wound repair material treatment chronic wound of embodiment of the invention preparation, obtained satisfactory effect.Studies show that by rat experimental, for chitin Cera Flava immiscible material provides theoretical foundation as medical wound repair material.Institute's experimental technique is that the wound surface with rat back is divided into two groups: (1) left side is matched group (normal saline group); (2) right side is experimental group (chitin Cera Flava cream group, it uses chitin Cera Flava immiscible material to be the preparation of the embodiment of the invention 1 method), tested 21 days, observe the healing state of wound surface, measure the content of matched group and experimental group wound tissue specimen epidermal growth factor (EGF), specifically referring to table 1 and table 2:
Table 1 different phase wound surface area and healing rate
Annotate: normal saline group and chitin Cera Flava are formed relatively p＜0.01 (there is significant difference p＜0.05) of face area
Table 2EGF assay result
Annotate: normal saline group and chitin Cera Flava are formed the face area relatively, #p＞0.05; * p＜0.01 (there is significant difference p＜0.05)
Result of experiment is that the wound surface area of experimental group and matched group significantly dwindles (P＜0.01), experimental group EGF content increases (51.375 ± 33.524pg/ml) in the time of the 7th day, be significantly higher than matched group EGF content (P=0.01＜0.05), because the content of union of wounded skin and epidermal growth factor is proportionate, use chitin Cera Flava cream to be significantly higher than matched group EGF content, further should demonstrate,prove chitin Cera Flava wound repair material and have the effect that promotes wound healing.
The above; only be the specific embodiment of the present invention, but protection scope of the present invention is not limited thereto, anyly belongs to those skilled in the art in the technical scope that the present invention discloses; the variation that can expect easily or replacement all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claim.
Claims (1)
1. a method for preparing medical wound repair material is characterized in that: 1～5 part of chitin is added in 90～95 parts of Oleum sesami soaked 20-24 hour, be heated to 100 ℃ with slow fire, kept 20-30 minute; Elimination chitin sediment, the immiscible material of reservation chitin and Oleum sesami; The immiscible material of described chitin and Oleum sesami is equipped with 1～5 part of Cera Flava, and mix homogeneously all melts Cera Flava, obtains chitin Cera Flava cream immiscible material after the cooling; Medical nonwoven gauze is immersed described chitin Cera Flava cream immiscible material, and the medical nonwoven gauze that speckles with described chitin Cera Flava cream immiscible material namely is described medical wound repair material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210045323.3A CN103285419B (en) | 2012-02-27 | 2012-02-27 | Method for preparing medical wound repair material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210045323.3A CN103285419B (en) | 2012-02-27 | 2012-02-27 | Method for preparing medical wound repair material |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103285419A true CN103285419A (en) | 2013-09-11 |
| CN103285419B CN103285419B (en) | 2014-12-10 |
Family
ID=49087302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210045323.3A Active CN103285419B (en) | 2012-02-27 | 2012-02-27 | Method for preparing medical wound repair material |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103285419B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105107013A (en) * | 2015-09-09 | 2015-12-02 | 上海美宝生命科技有限公司 | High oil content biological composite membrane and preparation method thereof |
| CN105664226A (en) * | 2016-03-30 | 2016-06-15 | 上海白衣缘生物工程有限公司 | Medical composite dressing and preparation method thereof |
| CN107441479A (en) * | 2017-08-08 | 2017-12-08 | 广东海洋大学 | Marine active peptide/chitin burn ointment for treating scald and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1410452A (en) * | 2002-11-26 | 2003-04-16 | 姜发堂 | Plant polysaccharide sponge body and its preparation method |
| CN1508353A (en) * | 2002-12-19 | 2004-06-30 | 全球生技股份有限公司 | Method for treating chitin for fiber antibacteria |
| CN1565533A (en) * | 2003-06-18 | 2005-01-19 | 东北林业大学 | Prescription of body surface shielding film and its preparing method |
| CN101220323A (en) * | 2007-01-09 | 2008-07-16 | 青岛大学 | Method for producing anhydrous oil removing cream |
| JP2009108018A (en) * | 2007-10-30 | 2009-05-21 | Bhn Kk | Ultraviolet resistivity enhancer and use thereof |
-
2012
- 2012-02-27 CN CN201210045323.3A patent/CN103285419B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1410452A (en) * | 2002-11-26 | 2003-04-16 | 姜发堂 | Plant polysaccharide sponge body and its preparation method |
| CN1508353A (en) * | 2002-12-19 | 2004-06-30 | 全球生技股份有限公司 | Method for treating chitin for fiber antibacteria |
| CN1565533A (en) * | 2003-06-18 | 2005-01-19 | 东北林业大学 | Prescription of body surface shielding film and its preparing method |
| CN101220323A (en) * | 2007-01-09 | 2008-07-16 | 青岛大学 | Method for producing anhydrous oil removing cream |
| JP2009108018A (en) * | 2007-10-30 | 2009-05-21 | Bhn Kk | Ultraviolet resistivity enhancer and use thereof |
Non-Patent Citations (1)
| Title |
|---|
| 李炳辉等: "甲壳素麻油蜂蜡膏促进糖尿病足创面愈合的研究进展", 《中华损伤与修复杂志（电子版）》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105107013A (en) * | 2015-09-09 | 2015-12-02 | 上海美宝生命科技有限公司 | High oil content biological composite membrane and preparation method thereof |
| CN105107013B (en) * | 2015-09-09 | 2017-11-24 | 上海美宝生命科技有限公司 | A kind of floorboard with high oil content biological composite membrane and preparation method thereof |
| CN105664226A (en) * | 2016-03-30 | 2016-06-15 | 上海白衣缘生物工程有限公司 | Medical composite dressing and preparation method thereof |
| CN107441479A (en) * | 2017-08-08 | 2017-12-08 | 广东海洋大学 | Marine active peptide/chitin burn ointment for treating scald and preparation method thereof |
| CN107441479B (en) * | 2017-08-08 | 2018-12-21 | 广东海洋大学 | Marine active peptide/chitin burn ointment for treating scald and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103285419B (en) | 2014-12-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101897990B (en) | Dressing composition used for inhibiting scars and accelerating wound healing and application thereof | |
| Shyna et al. | A nonadherent chitosan-polyvinyl alcohol absorbent wound dressing prepared via controlled freeze-dry technology | |
| CN103550817B (en) | A kind of Bacterial cellulose/shitosan composite sponge dressing and preparation method thereof | |
| CN107185031B (en) | A kind of biologically active medical dressing and preparation method thereof | |
| CN107320768B (en) | Contain the dressing and preparation method thereof of stem cell extract for wound repair | |
| CN105641740A (en) | Biological nutrition dressing for thoroughly treating skin injury and preparation method thereof | |
| CN109847088A (en) | Compound acellular dermal matrix biological dressing and preparation method thereof | |
| CN103755965A (en) | Epsilon-polylysine hydrogel and preparation method and application thereof | |
| CN103083712A (en) | Stem cells or other bioactive substances doped surgical dressing | |
| CN104107189A (en) | Skin care composition and preparation thereof | |
| CN113069591A (en) | Chitosan-calcium polyglutamate biological dressing and preparation method thereof | |
| CN103285419B (en) | Method for preparing medical wound repair material | |
| CN106139239A (en) | Full-service fluid dressing and preparation method thereof | |
| WO2017101020A1 (en) | Modified dressing | |
| CN109364286B (en) | Graphene oxide composite nanofiber structure dressing and preparation method thereof | |
| CN110876814A (en) | Liquid band-aid rich in antibacterial peptide and preparation method thereof | |
| CN110859989A (en) | Liquid band-aid and preparation method thereof | |
| CN204158771U (en) | A kind of Bacterial cellulose/chitosan composite sponge dressing | |
| CN104474573A (en) | Biological mask and preparation method thereof | |
| CN101856322B (en) | Sulfadiazine silver controlled-release gel and preparation method thereof | |
| CN103705985A (en) | Nasal polymer gel filling material and preparation method thereof | |
| CN109224124A (en) | A kind of liquid dressing of functions of stanching and promoting healing | |
| CN101766585A (en) | Medical paste film | |
| CN107714677A (en) | A kind of liquid Wound surface protection film and preparation method thereof | |
| CN108939141A (en) | It is a kind of for the Chinese medicine composite porous support material and preparation method of burn wound healing and application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |