CN103550817B - A kind of Bacterial cellulose/shitosan composite sponge dressing and preparation method thereof - Google Patents
A kind of Bacterial cellulose/shitosan composite sponge dressing and preparation method thereof Download PDFInfo
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- CN103550817B CN103550817B CN201310526128.7A CN201310526128A CN103550817B CN 103550817 B CN103550817 B CN 103550817B CN 201310526128 A CN201310526128 A CN 201310526128A CN 103550817 B CN103550817 B CN 103550817B
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- 229920002749 Bacterial cellulose Polymers 0.000 title claims abstract description 64
- 239000005016 bacterial cellulose Substances 0.000 title claims abstract description 64
- 239000002131 composite material Substances 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 27
- 229920001661 Chitosan Polymers 0.000 claims abstract description 20
- 239000004743 Polypropylene Substances 0.000 claims abstract description 15
- -1 polypropylene Polymers 0.000 claims abstract description 15
- 229920001155 polypropylene Polymers 0.000 claims abstract description 15
- 239000000243 solution Substances 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000007864 aqueous solution Substances 0.000 claims abstract description 11
- 229920002678 cellulose Polymers 0.000 claims abstract description 11
- 241000894006 Bacteria Species 0.000 claims abstract description 10
- 239000001913 cellulose Substances 0.000 claims abstract description 10
- 239000012153 distilled water Substances 0.000 claims abstract description 7
- 239000012467 final product Substances 0.000 claims abstract description 7
- 238000004108 freeze drying Methods 0.000 claims abstract description 7
- 239000011230 binding agent Substances 0.000 claims abstract description 6
- 239000003292 glue Substances 0.000 claims abstract description 5
- 238000001291 vacuum drying Methods 0.000 claims abstract description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 17
- 239000000835 fiber Substances 0.000 claims description 13
- 238000006116 polymerization reaction Methods 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- FHDQNOXQSTVAIC-UHFFFAOYSA-M 1-butyl-3-methylimidazol-3-ium;chloride Chemical compound [Cl-].CCCCN1C=C[N+](C)=C1 FHDQNOXQSTVAIC-UHFFFAOYSA-M 0.000 claims description 3
- 230000001580 bacterial effect Effects 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 150000004676 glycans Polymers 0.000 claims description 2
- 239000000853 adhesive Substances 0.000 claims 2
- 230000001070 adhesive effect Effects 0.000 claims 2
- 230000007935 neutral effect Effects 0.000 claims 2
- 150000004804 polysaccharides Polymers 0.000 claims 1
- 230000029663 wound healing Effects 0.000 abstract description 7
- 210000000589 cicatrix Anatomy 0.000 abstract description 6
- 230000023597 hemostasis Effects 0.000 abstract description 4
- 230000001954 sterilising effect Effects 0.000 abstract description 4
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 4
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 3
- 206010052428 Wound Diseases 0.000 description 24
- 208000027418 Wounds and injury Diseases 0.000 description 24
- 235000010980 cellulose Nutrition 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 229960000583 acetic acid Drugs 0.000 description 5
- 238000013461 design Methods 0.000 description 5
- 230000035876 healing Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 210000000416 exudates and transudate Anatomy 0.000 description 3
- 238000007710 freezing Methods 0.000 description 3
- 230000008014 freezing Effects 0.000 description 3
- 238000000227 grinding Methods 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
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- 230000001684 chronic effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000005251 gamma ray Effects 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
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- 230000035699 permeability Effects 0.000 description 1
- 239000008104 plant cellulose Substances 0.000 description 1
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- Materials For Medical Uses (AREA)
Abstract
The present invention relates to a kind of Bacterial cellulose/shitosan composite sponge dressing and preparation method thereof, described dressing from top to bottom includes Bacterial cellulose/chitosan sponge layer successively（1）, tack coat（2）And nonwoven layer（3）.Its preparation includes：（1）Bacteria cellulose film is boiled with NaOH aqueous solution, is then fully washed to neutrality with distilled water, after vacuum drying, make Bacterial cellulose fine strip body；（2）Prepare chitosan solution, add above-mentioned Bacterial cellulose fine strip body, freezed after standing and defoaming, last lyophilization, obtain final product Bacterial cellulose/shitosan composite sponge；（3）Bacterial cellulose/shitosan composite sponge is bonded on the polypropylene nonwoven of breathable microporous by binding agent, PUR or heat-sensitive glue, you can.The dressing of the present invention has hemostasis, antiinflammatory, sterilization, promotes the advantages of wound healing, no cicatrix, tensile strength are high, and retentiveness and permeable breathable are high, shape maintains ability strong, and preparation method is simple.
Description
Technical field
The invention belongs to medical dressing field, particularly to a kind of Bacterial cellulose/shitosan composite sponge dressing and its
Preparation method.
Background technology
Medical dressing is used to the material of treat wound.In minor burn（Ith, II degree）In the case of, generally use Medical coating
Wound site is covered by material, so that the evaporation of suppression body fluid and the intrusion preventing antibacterial.In severe burn（III degree）Feelings
It should use artificial skin under condition.
Commonly generally formed by 3 layers with medical dressing：Contact wound bed, absorbed layer and base material layer；Wound dressing is not
Can to take off conveniently, not damage new tissue growth with wound adhesion.Intermediate layer absorbs blood and slime, wound is played with dottle pin layer and makees
With protecting wound.Base material layer scribbles binding agent, so that dressing is positioned.
The major function of medical dressing is embodied in the following aspects：1. control the transudate of wound；2. avoid or control
The infection of wound；3. remove or control the stink that wound produces；4. mitigate pain；5. ensure the comfortableness of patient as best one can；⑥
Hidden wound is needed to beauty treatment by hurting sb.'s feelings with protecting；7. soon cicatrize a wound and make the wound surface after healing to have very
Good image appearance.From these requirements as can be seen that medical dressing Main Function be absorb transudate on wound, control thin
The breeding of bacterium, absorb stink and as well as possible protect wound, so that patient can be normally worked during wound healing and give birth to
Live.
With increasing of the aging of population and chronic ulcerative wound, the market of medical dressing and its commercial value also become
Obtain more and more important.Ever-changing due to wound due to causing, different wounds is in size, shape, number of transudate etc.
Everyway makes a big difference, so the requirement to dressing for the wound is also different.Development with material technology and medical treatment
More understandings of bound pair wound healing process, some Medical dressings are also just come out one after another.
Medical dressing fiber includes not absorbing fiber and absorbable fibre.Do not absorb in fiber, gauze and paraffine yarn
Cloth is the most frequently used medical dressing.In absorbable biological medical science fiber, predominantly bone collagen fiber, alginate fibre and shitosan are fine
Dimension.
Research shows, is had hemostasis, antiinflammatory, sterilization, is promoted wound healing with the medical dressing of chitin fiber preparation, and
And the wound surface after healing is similar to normal structure, no cicatrix.The work(that this kind of medical dressing can promote wound healing and reduce cicatrix
Can the reason, be because the catabolite N- acetyl glucosamine of macromole and D glucamine are all the nutrients of epidermal growth
Matter, they can promote the healing of wound surface, makes sarcostyle replace collagen fiber to reduce the formation of cicatrix.But shitosan is non-woven to be applied
The insufficient strength of material, is easily deformed ability, liquid absorption capacity is limited.Shitosan and other macromolecular material are blended, permissible
Make NEW TYPE OF COMPOSITE dressing, improve the performance of dressing, expand its purposes.
Bacterial cellulose is by certain biology（Predominantly antibacterial）The extracellular fiber element producing.Its molecular composition and plant
Fibres element is the same, is the straight chain being combined into by β-Isosorbide-5-Nitrae glycosidic bond by β-D glucose.It is except having plant cellulose
Good hydrophilic property, gamma ray resistant and excellent heat resistance, good biocompatibility, side base can chemically or physically be modified and be had green
Outside the premium properties such as color, also have the characteristics that some plant celluloses incomparable, such as very high purity, there is high Young
Modulus, high-tensile, extremely strong retentiveness and permeable breathable, splendid shape maintains ability and anti-tear power.Research shows,
Bacterial cellulose under moisture conditions high mechanical strength, have good permeability and skin-friendliness to liquid, gas and electrolyte
Good, nonirritant, can effective alleviating pain, absorb the liquid that wound oozes out, the quick healing of promotion wound, be conducive to skin group
Knit growth.
Content of the invention
The technical problem to be solved is to provide a kind of Bacterial cellulose/shitosan composite sponge dressing and its system
Preparation Method, this dressing has hemostasis, antiinflammatory, sterilization, promotes wound healing, no cicatrix, tensile strength high, retentiveness and permeable
The advantages of gas is high, shape maintains ability strong, preparation method is simple.
A kind of Bacterial cellulose/shitosan the composite sponge dressing of the present invention, described composite sponge dressing is from top to bottom
Include successively：Bacterial cellulose/chitosan sponge layer, tack coat and nonwoven layer.
Described Bacterial cellulose/chitosan sponge layer is made up of with shitosan bacterial fibers, wherein Bacterial cellulose
Weight/mass percentage composition is 1～20%.
Described nonwoven layer is polypropylene nonwoven, has breathable microporous.
Described tack coat is binding agent, PUR or heat-sensitive glue, so that dressing is positioned.
A kind of preparation method of the Bacterial cellulose/shitosan composite sponge dressing of the present invention, including：
（1）By bacteria cellulose film with NaOH aqueous solution decocting in water 20-60min at 50-90 DEG C, then abundant with distilled water
Wash to neutrality, after vacuum drying, make Bacterial cellulose fine strip body；
（2）Shitosan piece is placed in solvent, stands more than 4-8h, then stirring is made into the shell that mass content is 2-10%
Polysaccharide solution, adds above-mentioned Bacterial cellulose fine strip body, is freezed after standing and defoaming, and last lyophilization obtains final product antibacterial
Cellulose/Chitosan composite sponge；
（3）Bacterial cellulose/shitosan composite sponge has been bonded in ventilative micro- by binding agent, PUR or heat-sensitive glue
On the polypropylene nonwoven in hole, you can.
Step（1）Described in bacteria cellulose film the degree of polymerization be 200-5000.
Step（1）Described in NaOH aqueous solution mass concentration be 1%.
Step（2）Described in solvent be acetic acid aqueous solution or 1- butyl -3- methylimidazolium chloride.
Beneficial effect：
（1）The Bacterial cellulose of the present invention/shitosan composite sponge dressing had both had chitosan medical dressing hemostasis, had disappeared
Scorching, sterilization, promote wound healing, no cicatrix the advantages of, it is high also to have a Bacterial cellulose tensile strength, retentiveness and water-permeable and air permeable
Property high, the advantages of shape maintains ability strong, overcome the non-woven dressing strength of conventional shitosan not, be easily deformed and liquid is inhaled
Receive shortcoming limited in one's ability.
（2）Bacterial cellulose/chitosan sponge in the Bacterial cellulose of the present invention/shitosan composite sponge dressing is simultaneously
Play common medical dressing and touch wound bed and the effect of absorbed layer.
（3）In Bacterial cellulose body in the Bacterial cellulose of the present invention/shitosan composite sponge dressing, portion has in a large number
Micropore, has the potential use doing artificial skin with tissue-engineered composite.
（4）The preparation process of the Bacterial cellulose of the present invention/shitosan composite sponge dressing is simple, and technology controlling and process is easy.
Brief description
Fig. 1 is the structural representation of Bacterial cellulose/shitosan composite sponge dressing
Wherein 1- Bacterial cellulose/chitosan sponge layer, 2- tack coat, 3- nonwoven layer.
Specific embodiment
With reference to specific embodiment, the present invention is expanded on further.It should be understood that these embodiments are merely to illustrate the present invention
Rather than restriction the scope of the present invention.In addition, it is to be understood that after having read the content of present invention instruction, people in the art
Member can make various changes or modifications to the present invention, and these equivalent form of values equally fall within the application appended claims and limited
Scope.
Embodiment 1
By the degree of polymerization 800 bacteria cellulose film with the NaOH aqueous solution of mass fraction 1% decocting in water 45min at 80 DEG C, then
Fully washed to neutrality with distilled water（pH=7.0）, carry out being vacuum dried 12h at 75 DEG C.Become length with ball ball mill grinding
6.5mm, specific surface area 500m2The fine strip body of/g.
Shitosan piece is placed in 2%（Mass fraction) in acetic acid, stand more than 4 hours, then adding glacial acetic acid makes
Wherein acetic acid content reaches 4%, agitated is made into the chitosan solution that content is 3% (mass fraction).By above-mentioned Bacterial cellulose
Fine strip body is added in chitosan solution, and addition is the 15% of shitosan dry weight, standing and defoaming.
It is poured in nappy, the chitosan solution of above-mentioned interpolation Bacterial cellulose fine strip body in -20 DEG C of refrigerators
Lyophilization after freezing 7-9h, obtains final product Bacterial cellulose/shitosan composite sponge.
The polypropylene that Bacterial cellulose/shitosan composite sponge is bonded in breathable microporous by acroleic acid binding agent is non-
In woven cloths, become Bacterial cellulose/shitosan composite sponge dressing.Bacterial cellulose/the shape of chitosan sponge dressing, length
Degree is not limited to shown in Fig. 1, and its shape can design the arbitrary shape of suitable needs as needed, and length can set as needed
The length being calculated as example with polypropylene nonwoven identical length or being slightly less than polypropylene nonwoven.
Embodiment 2
By the degree of polymerization 1000 bacteria cellulose film with mass fraction 1%NaOH aqueous solution decocting in water 45min at 80 DEG C, then
Fully washed to neutrality with distilled water（pH=7.0）, carry out being vacuum dried 12h at 75 DEG C.Become length with ball ball mill grinding
5.5mm, specific surface area 600m2The fine strip body of/g.
Shitosan piece is placed in 3%（Mass fraction) in acetic acid, stand more than 4 hours, the agitated content that is made into is 3%
The chitosan solution of (mass fraction).Above-mentioned Bacterial cellulose fine strip body is added in chitosan solution, addition gathers for shell
The 10% of sugared dry weight, standing and defoaming.
It is poured in nappy, the chitosan solution of above-mentioned interpolation Bacterial cellulose fine strip body in -20 DEG C of refrigerators
Lyophilization after freezing 7-9h, obtains final product Bacterial cellulose/shitosan composite sponge.
Bacterial cellulose/shitosan composite sponge is bonded in the polypropylene nonwoven of breathable microporous by PUR
On, become Bacterial cellulose/shitosan composite sponge dressing.Bacterial cellulose/shitosan is combined the shape of composite, length
It is not limited to shown in Fig. 1, its shape can design the arbitrary shape of suitable needs as needed, length can design as needed
For for example with polypropylene nonwoven identical length or the length that is slightly less than polypropylene nonwoven.
Embodiment 3
By the bacteria cellulose film of the degree of polymerization 3000 with mass fraction 1%NaOH aqueous solution decocting in water 45min at 80 DEG C, and
Fully washed to neutrality with distilled water afterwards（pH=7.0）, carry out being vacuum dried 12h at 75 DEG C.Become length with ball ball mill grinding
9.5mm, specific surface area 400m2The fine strip body of/g.
Shitosan piece is placed in 1- butyl -3- methylimidazolium chloride [C4MIM] in Cl, stand more than 8 hours, agitated join
Become the chitosan solution that content is 9% (mass fraction).Above-mentioned Bacterial cellulose fine strip body is added in chitosan solution, adds
Dosage is the 20% of shitosan dry weight, standing and defoaming.
It is poured in nappy, the chitosan solution of above-mentioned interpolation Bacterial cellulose fine strip body in -20 DEG C of refrigerators
Lyophilization after freezing 7-9h, obtains final product Bacterial cellulose/shitosan composite sponge.
Bacterial cellulose/shitosan composite sponge is bonded in the polypropylene nonwoven of breathable microporous by heat-sensitive glue
On, become Bacterial cellulose/shitosan composite sponge dressing.Bacterial cellulose/shitosan is combined the shape of composite, length
It is not limited to shown in Fig. 1, its shape can design the arbitrary shape of suitable needs as needed, length can design as needed
For for example with polypropylene nonwoven identical length or the length that is slightly less than polypropylene nonwoven.
Claims (7)
1. a kind of Bacterial cellulose/shitosan composite sponge dressing it is characterised in that：Described composite sponge dressing is from top to bottom
Include successively：Bacterial cellulose/chitosan sponge layer (1), tack coat (2) and nonwoven layer (3)；Wherein, nonwoven layer
(3) it is polypropylene nonwoven, have breathable microporous；Described Bacterial cellulose/chitosan sponge layer is by Bacterial cellulose and shell
Polysaccharide forms, and wherein the weight/mass percentage composition of Bacterial cellulose is 1～20%；Preparation method includes：
(1) by bacteria cellulose film with NaOH aqueous solution decocting in water 20-60min at 50-90 DEG C, then fully washed with distilled water
To neutral, after vacuum drying, make Bacterial cellulose fine strip body；
(2) shitosan piece is placed in solvent, stands more than 4-8h, then stirring is made into the shitosan that mass content is 2-10%
Solution, adds above-mentioned Bacterial cellulose fine strip body, is freezed after standing and defoaming, and last lyophilization obtains final product bacterial fibers
Element/shitosan composite sponge；
(3) Bacterial cellulose/shitosan composite sponge is passed through adhesives in the polypropylene nonwoven having breathable microporous
On, you can.
2. a kind of Bacterial cellulose/shitosan composite sponge dressing according to claim 1 it is characterised in that：Described
Binding agent is PUR.
3. a kind of Bacterial cellulose/shitosan composite sponge dressing according to claim 2 it is characterised in that：Described
PUR is heat-sensitive glue.
4. the preparation method of a kind of Bacterial cellulose/shitosan composite sponge dressing as claimed in claim 1, including：
(1) by bacteria cellulose film with NaOH aqueous solution decocting in water 20-60min at 50-90 DEG C, then fully washed with distilled water
To neutral, after vacuum drying, make Bacterial cellulose fine strip body；
(2) shitosan piece is placed in solvent, stands more than 4-8h, then stirring is made into the shitosan that mass content is 2-10%
Solution, adds above-mentioned Bacterial cellulose fine strip body, is freezed after standing and defoaming, and last lyophilization obtains final product bacterial fibers
Element/shitosan composite sponge；
(3) Bacterial cellulose/shitosan composite sponge is passed through adhesives in the polypropylene nonwoven having breathable microporous
On, you can.
5. the preparation method of a kind of Bacterial cellulose/shitosan composite sponge dressing according to claim 4, its feature exists
In：The degree of polymerization of the bacteria cellulose film described in step (1) is 200-5000.
6. the preparation method of a kind of Bacterial cellulose/shitosan composite sponge dressing according to claim 4, its feature exists
In：The mass concentration of the NaOH aqueous solution described in step (1) is 1%.
7. the preparation method of a kind of Bacterial cellulose/shitosan composite sponge dressing according to claim 4, its feature exists
In：Solvent described in step (2) is acetic acid aqueous solution or 1- butyl -3- methylimidazolium chloride.
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| CN103990171B (en) * | 2014-05-26 | 2016-01-13 | 北京鼎瀚恒海生物科技发展有限公司 | A kind of based composite dressing for medical use and preparation method thereof |
| CN105965636B (en) * | 2016-07-12 | 2017-09-29 | 南京林业大学 | A kind of chitin modified timber of utilization biopolymer, the method for bamboo wood |
| CN106178063B (en) * | 2016-08-14 | 2019-09-27 | 山东省芙蓉堂制药有限公司 | A kind of no immunological rejection adhesive bandage |
| CN107383435B (en) * | 2017-08-03 | 2020-07-24 | 浙江大学台州研究院 | Preparation method of cellulose/chitosan-based nano fresh-keeping drug-loaded sponge |
| CN107550639A (en) * | 2017-09-30 | 2018-01-09 | 振德医疗用品股份有限公司 | A kind of temperature control wet combining |
| CN109260501A (en) * | 2018-11-15 | 2019-01-25 | 合肥华盖生物科技有限公司 | A kind of preparation method of Biodegradable wound dressing |
| CN110141677B (en) * | 2019-06-06 | 2022-07-08 | 东华大学 | Local acute hemostasis absorbable material and preparation method thereof |
| CN113117128A (en) * | 2019-12-30 | 2021-07-16 | 华东交通大学 | Homogeneous multifunctional bacterial cellulose-based skin dressing and preparation method thereof |
| CN111012941A (en) * | 2020-01-10 | 2020-04-17 | 中原工学院 | Electrostatic spinning double-layer long-acting antibacterial medical dressing and preparation method thereof |
| CN112972748A (en) * | 2021-02-02 | 2021-06-18 | 李娟� | Method for preparing wound hemostatic dressing by adopting chitosan |
| CN112877384A (en) * | 2021-03-26 | 2021-06-01 | 哈尔滨理工大学 | Preparation method of bacterial cellulose, bacterial cellulose-chitosan composite gel skin-care mask and preparation method thereof |
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| CN202036418U (en) * | 2011-03-30 | 2011-11-16 | 李志安 | Hemostasis dressing |
| CN102631261B (en) * | 2012-05-07 | 2014-04-16 | 钟春燕 | Wet composite dressing and sealed negative pressure drainage device therefrom |
| CN202822443U (en) * | 2012-05-07 | 2013-03-27 | 钟春燕 | Closed-type negative pressure drainage device |
| CN103007335A (en) * | 2012-12-28 | 2013-04-03 | 海南大学 | Method for preparing chitosan oligosaccharide/bacterial cellulose sponge |
| CN103120803B (en) * | 2012-12-29 | 2015-03-25 | 钟春燕 | Preparation method of bacterial cellulose composite chitosan moist antimicrobial dressing |
| CN103055344B (en) * | 2012-12-31 | 2014-06-18 | 上海昌颌医药科技有限公司 | Bacterial cellulose/chitosan composite medical dressing and preparation method thereof |
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