CN103550817A - Bacterial cellulose/chitosan composite sponge dressing and preparation method thereof - Google Patents
Bacterial cellulose/chitosan composite sponge dressing and preparation method thereof Download PDFInfo
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- CN103550817A CN103550817A CN201310526128.7A CN201310526128A CN103550817A CN 103550817 A CN103550817 A CN 103550817A CN 201310526128 A CN201310526128 A CN 201310526128A CN 103550817 A CN103550817 A CN 103550817A
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- 229920002749 Bacterial cellulose Polymers 0.000 title claims abstract description 64
- 239000005016 bacterial cellulose Substances 0.000 title claims abstract description 64
- 239000002131 composite material Substances 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 24
- 239000004743 Polypropylene Substances 0.000 claims abstract description 14
- -1 polypropylene Polymers 0.000 claims abstract description 14
- 229920001155 polypropylene Polymers 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000000243 solution Substances 0.000 claims abstract description 12
- 239000007864 aqueous solution Substances 0.000 claims abstract description 10
- 229920002678 cellulose Polymers 0.000 claims abstract description 9
- 239000001913 cellulose Substances 0.000 claims abstract description 8
- 239000012153 distilled water Substances 0.000 claims abstract description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 17
- 239000000835 fiber Substances 0.000 claims description 13
- 241000894006 Bacteria Species 0.000 claims description 7
- 239000011230 binding agent Substances 0.000 claims description 6
- 239000003292 glue Substances 0.000 claims description 5
- 238000006116 polymerization reaction Methods 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 238000001291 vacuum drying Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 3
- 230000001580 bacterial effect Effects 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims description 2
- 230000029663 wound healing Effects 0.000 abstract description 7
- 238000007710 freezing Methods 0.000 abstract description 5
- 230000008014 freezing Effects 0.000 abstract description 5
- 230000007935 neutral effect Effects 0.000 abstract description 4
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- 230000001070 adhesive effect Effects 0.000 abstract 2
- 238000001035 drying Methods 0.000 abstract 2
- 239000004745 nonwoven fabric Substances 0.000 abstract 2
- 239000004831 Hot glue Substances 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
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- 238000009835 boiling Methods 0.000 abstract 1
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- 239000012528 membrane Substances 0.000 abstract 1
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- 206010052428 Wound Diseases 0.000 description 24
- 208000027418 Wounds and injury Diseases 0.000 description 24
- 235000010980 cellulose Nutrition 0.000 description 6
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- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 229920002101 Chitin Polymers 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
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- 150000001875 compounds Chemical class 0.000 description 2
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- SDOFMBGMRVAJNF-SLPGGIOYSA-N (2r,3r,4r,5s)-6-aminohexane-1,2,3,4,5-pentol Chemical compound NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO SDOFMBGMRVAJNF-SLPGGIOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 1
- 206010039580 Scar Diseases 0.000 description 1
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- 230000032683 aging Effects 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
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- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
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- 239000012362 glacial acetic acid Substances 0.000 description 1
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- 235000015097 nutrients Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Materials For Medical Uses (AREA)
Abstract
The invention relates to a bacterial cellulose/ chitosan composite sponge dressing and preparation method thereof. The dressing comprises a cellulose/ chitosan composite sponge layer (1), an adhering layer (2) and a nonwoven fabric layer (3) which are placed from top to bottom in sequence. The preparation method comprises the following steps of (1) boiling a bacterial cellulose membrane with an NaOH aqueous solution, fully washing with distilled water to reach neutral state, and then drying in vacuum to obtain bacterial cellulose fibrid; (2) preparing a chitosan solution, adding the bacterial cellulose fibrid, standing and defoaming, freezing, and finally freezing and drying to obtain bacterial cellulose/ chitosan composite sponge; and (3) adhering the bacterial cellulose/ chitosan composite sponge to a polypropylene nonwoven fabric with permeable micropores through an adhesive, a hot melt adhesive or a thermosensitive adhesive, thus obtaining the bacterial cellulose/ chitosan composite sponge dressing. The dressing has the effects of stopping bleeding, diminishing inflammation, sterilizing, promoteing the wound healing, and has the advantages of no scar, high tensile strength, high water binding capacity and air and water permeability, high shape maintaining ability, etc. The preparation method is simple.
Description
Technical field
The invention belongs to medical dressing field, particularly a kind of Bacterial cellulose/chitosan composite sponge dressing and preparation method thereof.
Background technology
Medical dressing is for treating the material of wound.Minor burn (I, II degree) in the situation that, conventionally with medical dressing, wound site is covered, to suppress the evaporation of body fluid and prevent the intrusion of antibacterial.Severe burn (III degree) in the situation that, should use artificial skin.
Commonly with medical dressing, conventionally by 3 layers, form: contact wound bed, absorbed layer and base material layer; Wound dressing can not with wound adhesion, take off conveniently, do not damage new tissue growth.Intermediate layer absorbs blood and slime, wound is played every cushioning effect to protection wound.Base material layer scribbles binding agent, makes dressing location.
The major function of medical dressing is embodied in the following aspects: the transudate of 1. controlling wound; 2. avoid or control the infection of wound; 3. remove or control the stink that wound produces; 4. ease the pain; 5. guarantee as best one can patient's comfortableness; 6. the needs that hidden wound is hurted sb.'s feelings to beauty treatment with protection; 7. cicatrize a wound soon and make the wound surface after healing have good image appearance.From these require, can find out, medical dressing Main Function is absorb the transudate on wound, the breeding of controlling antibacterial, absorption stink and protect as well as possible wound, makes patient can normally work and live during wound healing.
Along with increasing of the aging of population and chronic ulcerative wound, the market of medical dressing and its commercial value also become more and more important.Owing to causing, the reason of wound is ever-changing, and different wounds makes a big difference at everyways such as the numbers of size, shape, transudate, so wound is also different to the requirement of dressing.Along with development and the more understanding of medical profession to wound healing process of material technology, some Medical dressings are also just come out one after another.
Medical dressing comprises and does not absorb fiber and absorbable fibre with fiber.Do not absorb in fiber, gauze and paraffine gauze are the most frequently used medical dressing.In absorbable biological medical science fiber, be mainly bone collagen fiber, alginate fibre and chitin fiber.
Research shows, the medical dressing of preparing with chitin fiber has hemostasis, antiinflammatory, sterilization, promotion wound healing, and the wound surface after healing is similar to normal structure, without cicatrix.This class medical dressing can promote wound healing and reduce the reason of the function of cicatrix, because macromolecular catabolite N-acetyl glucosamine and D-glucamine are all the nutrient substance of epidermal growth, they can promote the healing of wound surface, make sarcostyle replace collagen fiber to reduce the formation of cicatrix.But the insufficient strength of the non-woven dressing of chitosan, easy deformability, liquid absorption capacity is limited.By chitosan and other macromolecular material blend, can make NEW TYPE OF COMPOSITE dressing, improve the performance of dressing, expand its purposes.
Bacterial cellulose is the extracellular fiber element of being produced by certain biology (being mainly antibacterial).Its molecular composition is the same with plant cellulose, is the straight chain being combined into by β-Isosorbide-5-Nitrae glycosidic bond by β-D glucose.It except thering is plant cellulose good hydrophilic property, gamma ray resistant and excellent heat resistance, good biocompatibility, side group can carry out chemistry or physical modification and have the premium properties such as green, also there is the incomparable feature of some plant celluloses, very high purity for example, there is high Young's modulus, high-tensile, extremely strong retentiveness and water-permeable and air permeable, splendid shape maintains ability and anti-tear power.Research shows, Bacterial cellulose mechanical strength under moisture conditions is high, liquid, gas and electrolyte are had to good permeability, good with skin-friendliness, nonirritant, effective alleviating pain, absorb the liquid that wound oozes out, promote the quickly-healing of wound, be conducive to skin histology growth.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Bacterial cellulose/chitosan composite sponge dressing and preparation method thereof, this dressing has hemostasis, antiinflammatory, sterilization, promotion wound healing, high without cicatrix, tensile strength, the advantages such as retentiveness and water-permeable and air permeable are high, shape maintains ability is strong, preparation method is simple.
A kind of Bacterial cellulose/chitosan composite sponge dressing of the present invention, described composite sponge dressing from top to bottom comprises successively: Bacterial cellulose/chitosan sponge layer, tack coat and nonwoven layer.
Described Bacterial cellulose/chitosan sponge layer is comprised of bacterial fibers and chitosan, and wherein the quality percentage composition of Bacterial cellulose is 1～20%.
Described nonwoven layer is polypropylene nonwoven, has ventilative micropore.
Described tack coat is binding agent, PUR or heat-sensitive glue, makes dressing location.
The preparation method of a kind of Bacterial cellulose/chitosan composite sponge dressing of the present invention, comprising:
(1) by NaOH aqueous solution decocting in water 20-60min at 50-90 ℃ for bacteria cellulose film, then with distilled water, fully wash to neutrality, after vacuum drying, make Bacterial cellulose fine strip body;
(2) chitosan sheet is placed in to solvent, more than standing 4-8h, then stirs and be made into the chitosan solution that mass content is 2-10%, add again above-mentioned Bacterial cellulose fine strip body, after standing and defoaming, carry out freezingly, last lyophilization, obtains Bacterial cellulose/chitosan composite sponge;
(3) Bacterial cellulose/chitosan composite sponge is bondd in having on the polypropylene nonwoven of ventilative micropore by binding agent, PUR or heat-sensitive glue.
The degree of polymerization of the bacteria cellulose film described in step (1) is 200-5000.
The mass concentration of the NaOH aqueous solution described in step (1) is 1%.
Solvent described in step (2) is acetic acid aqueous solution or 1-butyl-3-methyl imidazolitm chloride.
Beneficial effect:
(1) Bacterial cellulose/chitosan composite sponge dressing of the present invention both there is chitosan medical dressing hemostasis, antiinflammatory, sterilization, promotion wound healing, without advantages such as cicatrixes, also there is Bacterial cellulose tensile strength high, the advantages such as retentiveness and water-permeable and air permeable are high, shape maintains ability is strong, have overcome the non-woven dressing strength of conventional chitosan and not, have easily been out of shape and the limited shortcoming of liquid absorption capacity.
(2) Bacterial cellulose/chitosan sponge in Bacterial cellulose/chitosan composite sponge dressing of the present invention plays the effect that common medical dressing touches wound bed and absorbed layer simultaneously.
(3) the Bacterial cellulose body inside in Bacterial cellulose/chitosan composite sponge dressing of the present invention has a large amount of micropores, has the potential use of doing artificial skin with tissue-engineered composite.
(4) preparation process of Bacterial cellulose/chitosan composite sponge dressing of the present invention is simple, and technology controlling and process is easy.
Accompanying drawing explanation
Fig. 1 is the structural representation of Bacterial cellulose/chitosan composite sponge dressing
1-Bacterial cellulose/chitosan sponge layer wherein, 2-tack coat, 3-nonwoven layer.
The specific embodiment
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment are only not used in and limit the scope of the invention for the present invention is described.In addition should be understood that those skilled in the art can make various changes or modifications the present invention after having read the content of the present invention's instruction, these equivalent form of values fall within the application's appended claims limited range equally.
Embodiment 1
NaOH aqueous solution decocting in water 45min at 80 ℃ by the degree of polymerization 800 bacteria cellulose films with mass fraction 1%, then fully washs to neutral (pH=7.0) with distilled water, carries out vacuum drying 12h at 75 ℃.With ball ball mill grinding, become length 6.5mm, specific surface area 500m
2the fine strip body of/g.
Chitosan sheet is placed in to (mass fraction) acetic acid of 2%, standing more than 4 hours, and then add glacial acetic acid to make wherein acetic acid content reach 4%, through stirring, be made into the chitosan solution that content is 3% (mass fraction).Above-mentioned Bacterial cellulose fine strip body is added in chitosan solution, and addition is 15% of chitosan dry weight, standing and defoaming.
Chitosan solution by above-mentioned interpolation Bacterial cellulose fine strip body, is poured in nappy, and freezing 7-9h postlyophilization in-20 ℃ of refrigerators, obtains Bacterial cellulose/chitosan composite sponge.
Bacterial cellulose/chitosan composite sponge is bonded on the polypropylene nonwoven of ventilative micropore by acroleic acid binding agent, becomes Bacterial cellulose/chitosan composite sponge dressing.Shape, the length of the dressing of Bacterial cellulose/chitosan sponge are not limited to shown in Fig. 1, its shape can design the arbitrary shape of applicable needs as required, and length for example can be designed to as required with polypropylene nonwoven identical length or be slightly less than the length of polypropylene nonwoven.
Embodiment 2
By the degree of polymerization 1000 bacteria cellulose films mass fraction 1%NaOH aqueous solution decocting in water 45min at 80 ℃, then with distilled water, fully wash to neutral (pH=7.0), at 75 ℃, carry out vacuum drying 12h.With ball ball mill grinding, become length 5.5mm, specific surface area 600m
2the fine strip body of/g.
Chitosan sheet is placed in to (mass fraction) acetic acid of 3%, standing more than 4 hours, through stirring, be made into the chitosan solution that content is 3% (mass fraction).Above-mentioned Bacterial cellulose fine strip body is added in chitosan solution, and addition is 10% of chitosan dry weight, standing and defoaming.
Chitosan solution by above-mentioned interpolation Bacterial cellulose fine strip body, is poured in nappy, and freezing 7-9h postlyophilization in-20 ℃ of refrigerators, obtains Bacterial cellulose/chitosan composite sponge.
Bacterial cellulose/chitosan composite sponge is bondd in having on the polypropylene nonwoven of ventilative micropore by PUR, become Bacterial cellulose/chitosan composite sponge dressing.The shape of the compound composite of Bacterial cellulose/chitosan, length are not limited to shown in Fig. 1, its shape can design the arbitrary shape of applicable needs as required, and length for example can be designed to as required with polypropylene nonwoven identical length or be slightly less than the length of polypropylene nonwoven.
Embodiment 3
By mass fraction 1%NaOH aqueous solution decocting in water 45min at 80 ℃ for the bacteria cellulose film of the degree of polymerization 3000, then with distilled water, fully wash to neutral (pH=7.0), at 75 ℃, carry out vacuum drying 12h.With ball ball mill grinding, become length 9.5mm, specific surface area 400m
2the fine strip body of/g.
Chitosan sheet is placed in to 1-butyl-3-methyl imidazolitm chloride [C
4mIM] in Cl, standing more than 8 hours, through stirring, be made into the chitosan solution that content is 9% (mass fraction).Above-mentioned Bacterial cellulose fine strip body is added in chitosan solution, and addition is 20% of chitosan dry weight, standing and defoaming.
Chitosan solution by above-mentioned interpolation Bacterial cellulose fine strip body, is poured in nappy, and freezing 7-9h postlyophilization in-20 ℃ of refrigerators, obtains Bacterial cellulose/chitosan composite sponge.
Bacterial cellulose/chitosan composite sponge is bondd in having on the polypropylene nonwoven of ventilative micropore by heat-sensitive glue, become Bacterial cellulose/chitosan composite sponge dressing.The shape of the compound composite of Bacterial cellulose/chitosan, length are not limited to shown in Fig. 1, its shape can design the arbitrary shape of applicable needs as required, and length for example can be designed to as required with polypropylene nonwoven identical length or be slightly less than the length of polypropylene nonwoven.
Claims (8)
1. Bacterial cellulose/chitosan composite sponge dressing, is characterized in that: described composite sponge dressing from top to bottom comprises successively: Bacterial cellulose/chitosan sponge layer (1), tack coat (2) and nonwoven layer (3).
2. a kind of Bacterial cellulose/chitosan composite sponge dressing according to claim 1, is characterized in that: described Bacterial cellulose/chitosan sponge layer is comprised of bacterial fibers and chitosan, and wherein the quality percentage composition of Bacterial cellulose is 1～20%.
3. a kind of Bacterial cellulose/chitosan composite sponge dressing according to claim 1, is characterized in that: described nonwoven layer (3) is polypropylene nonwoven.
4. a kind of Bacterial cellulose/chitosan composite sponge dressing according to claim 1, is characterized in that: described tack coat (2) is binding agent, PUR or heat-sensitive glue.
5. the preparation method of a kind of Bacterial cellulose/chitosan composite sponge dressing as claimed in claim 1, comprising:
(1) by NaOH aqueous solution decocting in water 20-60min at 50-90 ℃ for bacteria cellulose film, then with distilled water, fully wash to neutrality, after vacuum drying, make Bacterial cellulose fine strip body;
(2) chitosan sheet is placed in to solvent, more than standing 4-8h, then stirs and be made into the chitosan solution that mass content is 2-10%, add again above-mentioned Bacterial cellulose fine strip body, after standing and defoaming, carry out freezingly, last lyophilization, obtains Bacterial cellulose/chitosan composite sponge;
(3) Bacterial cellulose/chitosan composite sponge is bondd in having on the polypropylene nonwoven of ventilative micropore by binding agent, PUR or heat-sensitive glue.
6. the preparation method of a kind of Bacterial cellulose/chitosan composite sponge dressing according to claim 5, is characterized in that: the degree of polymerization of the bacteria cellulose film described in step (1) is 200-5000.
7. the preparation method of a kind of Bacterial cellulose/chitosan composite sponge dressing according to claim 5, is characterized in that: the mass concentration of the NaOH aqueous solution described in step (1) is 1%.
8. the preparation method of a kind of Bacterial cellulose/chitosan composite sponge dressing according to claim 5, is characterized in that: the solvent described in step (2) is acetic acid aqueous solution or 1-butyl-3-methyl imidazolitm chloride.
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| CN201310526128.7A CN103550817B (en) | 2013-10-29 | 2013-10-29 | A kind of Bacterial cellulose/shitosan composite sponge dressing and preparation method thereof |
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| CN103550817B CN103550817B (en) | 2017-03-01 |
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Cited By (11)
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| CN103990171A (en) * | 2014-05-26 | 2014-08-20 | 北京鼎瀚恒海生物科技发展有限公司 | Compound medical dressing and preparation method thereof |
| CN105965636A (en) * | 2016-07-12 | 2016-09-28 | 南京林业大学 | Method for modifying wood and bamboo wood through biopolymer-chitosan |
| CN106178063A (en) * | 2016-08-14 | 2016-12-07 | 张天奇 | A kind of without immunologic rejection adhesive bandage |
| CN107383435A (en) * | 2017-08-03 | 2017-11-24 | 浙江大学台州研究院 | A kind of fresh-keeping preparation method for carrying medicine sponge of Cellulose/Chitosan base nanometer |
| CN107550639A (en) * | 2017-09-30 | 2018-01-09 | 振德医疗用品股份有限公司 | A kind of temperature control wet combining |
| CN109260501A (en) * | 2018-11-15 | 2019-01-25 | 合肥华盖生物科技有限公司 | A kind of preparation method of Biodegradable wound dressing |
| CN110141677A (en) * | 2019-06-06 | 2019-08-20 | 东华大学 | A kind of topical acute hemostasis absorbable material and preparation method thereof |
| CN111012941A (en) * | 2020-01-10 | 2020-04-17 | 中原工学院 | Electrostatic spinning double-layer long-acting antibacterial medical dressing and preparation method thereof |
| CN112877384A (en) * | 2021-03-26 | 2021-06-01 | 哈尔滨理工大学 | Preparation method of bacterial cellulose, bacterial cellulose-chitosan composite gel skin-care mask and preparation method thereof |
| CN112972748A (en) * | 2021-02-02 | 2021-06-18 | 李娟� | Method for preparing wound hemostatic dressing by adopting chitosan |
| CN113117128A (en) * | 2019-12-30 | 2021-07-16 | 华东交通大学 | Homogeneous multifunctional bacterial cellulose-based skin dressing and preparation method thereof |
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