CN204158771U - A kind of Bacterial cellulose/chitosan composite sponge dressing - Google Patents
A kind of Bacterial cellulose/chitosan composite sponge dressing Download PDFInfo
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- CN204158771U CN204158771U CN201320674543.2U CN201320674543U CN204158771U CN 204158771 U CN204158771 U CN 204158771U CN 201320674543 U CN201320674543 U CN 201320674543U CN 204158771 U CN204158771 U CN 204158771U
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- bacterial cellulose
- chitosan
- dressing
- composite sponge
- wound
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- 229920001661 Chitosan Polymers 0.000 title claims abstract description 57
- 229920002749 Bacterial cellulose Polymers 0.000 title claims abstract description 47
- 239000005016 bacterial cellulose Substances 0.000 title claims abstract description 47
- 239000002131 composite material Substances 0.000 title claims abstract description 32
- 239000004743 Polypropylene Substances 0.000 claims abstract description 14
- -1 polypropylene Polymers 0.000 claims abstract description 14
- 229920001155 polypropylene Polymers 0.000 claims abstract description 14
- 239000011230 binding agent Substances 0.000 claims description 6
- 239000003292 glue Substances 0.000 claims description 4
- 230000029663 wound healing Effects 0.000 abstract description 7
- 210000000589 cicatrix Anatomy 0.000 abstract description 6
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 4
- 230000023597 hemostasis Effects 0.000 abstract description 4
- 238000002360 preparation method Methods 0.000 abstract description 4
- 230000001954 sterilising effect Effects 0.000 abstract description 4
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 4
- 206010052428 Wound Diseases 0.000 description 24
- 208000027418 Wounds and injury Diseases 0.000 description 24
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 14
- 239000000835 fiber Substances 0.000 description 13
- 239000000243 solution Substances 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000007864 aqueous solution Substances 0.000 description 6
- 229920002678 cellulose Polymers 0.000 description 6
- 235000010980 cellulose Nutrition 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 229960000583 acetic acid Drugs 0.000 description 5
- 239000001913 cellulose Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000012153 distilled water Substances 0.000 description 4
- 238000007710 freezing Methods 0.000 description 4
- 230000008014 freezing Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000006116 polymerization reaction Methods 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 238000001291 vacuum drying Methods 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 210000000416 exudates and transudate Anatomy 0.000 description 3
- 238000000227 grinding Methods 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- FHDQNOXQSTVAIC-UHFFFAOYSA-M 1-butyl-3-methylimidazol-3-ium;chloride Chemical compound [Cl-].CCCCN1C=C[N+](C)=C1 FHDQNOXQSTVAIC-UHFFFAOYSA-M 0.000 description 2
- 229920002101 Chitin Polymers 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000008104 plant cellulose Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- SDOFMBGMRVAJNF-SLPGGIOYSA-N (2r,3r,4r,5s)-6-aminohexane-1,2,3,4,5-pentol Chemical compound NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO SDOFMBGMRVAJNF-SLPGGIOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 1
- 206010039580 Scar Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000005251 gamma ray Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
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- Materials For Medical Uses (AREA)
Abstract
This utility model relates to a kind of Bacterial cellulose/chitosan composite sponge dressing, and described dressing comprises Bacterial cellulose/chitosan sponge layer (1), tack coat (2) and nonwoven layer (3) from top to bottom successively; Described nonwoven layer (3) is polypropylene nonwoven.Dressing of the present utility model has hemostasis, antiinflammatory, sterilization, promotion wound healing, high without cicatrix, tensile strength, and retentiveness and the advantage such as water-permeable and air permeable is high, shape maintains ability is strong, preparation method is simple.
Description
Technical field
This utility model belongs to medical dressing field, particularly a kind of Bacterial cellulose/chitosan composite sponge dressing.
Background technology
Medical dressing is used to the material for the treatment of wound.When minor burn (I, II degree), usually with medical dressing, wound site is covered, to suppress the evaporation of body fluid and to prevent the intrusion of antibacterial.When severe burn (III degree), artificial skin should be used.
Common medical dressing forms by 3 layers usually: contact wound bed, absorbed layer and base material layer; Wound dressing can not with wound adhesion, take off conveniently, not damage new tissue growth.Intermediate layer absorbs blood and slime, plays every cushioning effect to wound, protection wound.Base material layer scribbles binding agent, and dressing is located.
The major function of medical dressing is embodied in the following aspects: the transudate 1. controlling wound; 2. avoid or control the infection of wound; 3. remove or control the stink that wound produces; 4. ease the pain; 5. the comfortableness of patient is ensured as best one can; 6. hidden wound is to protect the needs by hurting sb.'s feelings to beauty treatment; 7. to cicatrize a wound soon and wound surface after making healing has good image appearance.In requiring as can be seen from these, medical dressing Main Function is the transudate absorbed on wound, the breeding controlling antibacterial, absorbs stink and protect wound as well as possible, makes patient can normally work and live during wound healing.
Along with increasing of the aging of population and chronic ulcerative wound, market and its commercial value of medical dressing also become more and more important.Owing to causing the reason of wound ever-changing, different wounds makes a big difference, so wound is also different to the requirement of dressing at the everyway such as number of size, shape, transudate.Along with the development of material technology and medical profession are to the more understanding of wound healing process, some Medical dressings are also just come out one after another.
Medical dressing fiber comprises and does not absorb fiber and absorbable fibre.Do not absorb in fiber, gauze and paraffine gauze are the most frequently used medical dressing.In absorbable biological medical science fiber, be mainly bone collagen fiber, alginate fibre and chitin fiber.
Research shows, has hemostasis, antiinflammatory, sterilization, promotion wound healing with medical dressing prepared by chitin fiber, and healing after wound surface similar to normal structure, without cicatrix.This kind of medical dressing can promote the reason of the function of wound healing and minimizing cicatrix, because macromolecular catabolite N-acetyl glucosamine and D-glucamine are all the nutrient substance of epidermal growth, they can promote the healing of wound surface, make sarcostyle replace collagen fiber to reduce the formation of cicatrix.But the insufficient strength of the non-woven dressing of chitosan, easy deformability, liquid absorption capacity is limited.By blended to chitosan and other macromolecular material, NEW TYPE OF COMPOSITE dressing can be made, improve the performance of dressing, expand its purposes.
Bacterial cellulose is the extracellular fiber element produced by certain biology (being mainly antibacterial).Its molecular composition is the same with plant cellulose, is the straight chain be combined into by β-Isosorbide-5-Nitrae glycosidic bond by β-D glucose.It except having plant cellulose good hydrophilic property, gamma ray resistant and excellent heat resistance, good biocompatibility, side base can carry out chemistry or physical modification and have except the premium properties such as green, also there is the feature that some plant celluloses are incomparable, such as very high purity, there is high Young's modulus, high-tensile, extremely strong retentiveness and water-permeable and air permeable, splendid shape maintains ability and anti-tear power.Research shows, Bacterial cellulose mechanical strength under moisture conditions is high, have liquid, gas and electrolyte good permeability and skin-friendliness good, nonirritant, can effective alleviating pain, absorb the liquid that wound oozes out, promote the quickly-healing of wound, be conducive to skin histology growth.
Utility model content
Technical problem to be solved in the utility model is to provide a kind of Bacterial cellulose/chitosan composite sponge dressing, this dressing has hemostasis, antiinflammatory, sterilization, promotion wound healing, high without cicatrix, tensile strength, retentiveness and the advantage such as water-permeable and air permeable is high, shape maintains ability is strong, preparation method is simple.
A kind of Bacterial cellulose/chitosan composite sponge dressing of the present utility model, described composite sponge dressing from top to bottom comprises successively: Bacterial cellulose/chitosan sponge layer, tack coat and nonwoven layer.
Described Bacterial cellulose/chitosan sponge layer is made up of bacterial fibers and chitosan, and wherein the mass percentage of Bacterial cellulose is 1 ~ 20%.
Described nonwoven layer is polypropylene nonwoven, has breathable microporous.
Described tack coat is binding agent, PUR or heat-sensitive glue, and dressing is located.
The preparation method of a kind of Bacterial cellulose/chitosan composite sponge dressing of the present utility model, comprising:
(1) by bacteria cellulose film NaOH aqueous solution decocting in water 20-60min at 50-90 DEG C, then fully wash to neutrality with distilled water, after vacuum drying, make Bacterial cellulose fine strip body;
(2) chitosan sheet is placed in solvent, leaves standstill more than 4-8h, then stir and be made into the chitosan solution that mass content is 2-10%, add above-mentioned Bacterial cellulose fine strip body again, carry out freezing after standing and defoaming, last lyophilization, obtain Bacterial cellulose/chitosan composite sponge;
(3) Bacterial cellulose/chitosan composite sponge is bonded on the polypropylene nonwoven of breathable microporous by binding agent, PUR or heat-sensitive glue.
The degree of polymerization of the bacteria cellulose film described in step (1) is 200-5000.
The mass concentration of the NaOH aqueous solution described in step (1) is 1%.
Solvent described in step (2) is acetic acid aqueous solution or 1-butyl-3-methylimidazolium chloride.
Beneficial effect:
(1) Bacterial cellulose of the present utility model/chitosan composite sponge dressing both had chitosan medical dressing hemostasis, antiinflammatory, sterilization, promotion wound healing, without advantages such as cicatrixes, also there is Bacterial cellulose tensile strength high, retentiveness and the advantage such as water-permeable and air permeable is high, shape maintains ability is strong, overcome the non-woven dressing strength of conventional chitosan not, easily distortion and the limited shortcoming of liquid absorption capacity.
(2) Bacterial cellulose/chitosan sponge in Bacterial cellulose of the present utility model/chitosan composite sponge dressing plays the effect that common medical dressing touches wound bed and absorbed layer simultaneously.
(3) the bacterial fibers ferritic inside in Bacterial cellulose of the present utility model/chitosan composite sponge dressing has a large amount of micropore, has the potential use doing artificial skin with tissue-engineered composite.
(4) preparation process of Bacterial cellulose of the present utility model/chitosan composite sponge dressing is simple, and technology controlling and process is easy.
Accompanying drawing explanation
Fig. 1 is the structural representation of Bacterial cellulose/chitosan composite sponge dressing
Wherein 1-Bacterial cellulose/chitosan sponge layer, 2-tack coat, 3-nonwoven layer.
Detailed description of the invention
Below in conjunction with specific embodiment, set forth this utility model further.Should be understood that these embodiments are only not used in restriction scope of the present utility model for illustration of this utility model.In addition should be understood that those skilled in the art can make various changes or modifications this utility model, and these equivalent form of values fall within the application's appended claims limited range equally after the content of having read this utility model instruction.
Embodiment 1
By NaOH aqueous solution decocting in water 45min at 80 DEG C of the degree of polymerization 800 bacteria cellulose film mass fraction 1%, then fully wash to neutral (pH=7.0) with distilled water, at 75 DEG C, carry out vacuum drying 12h.Length 6.5mm, specific surface area 500m is become with ball ball mill grinding
2the fine strip body of/g.
Chitosan sheet being placed in (mass fraction) acetic acid of 2%, leaving standstill more than 4 hours, and then add glacial acetic acid and make wherein acetic acid content reach 4%, being made into through stirring the chitosan solution that content is 3% (mass fraction).Add in chitosan solution by above-mentioned Bacterial cellulose fine strip body, addition is 15% of chitosan dry weight, standing and defoaming.
By the chitosan solution of above-mentioned interpolation Bacterial cellulose fine strip body, be poured in nappy, freezing 7-9h postlyophilization in-20 DEG C of refrigerators, obtains Bacterial cellulose/chitosan composite sponge.
Bacterial cellulose/chitosan composite sponge is bonded on the polypropylene nonwoven of breathable microporous by acroleic acid binding agent, becomes Bacterial cellulose/chitosan composite sponge dressing.Bacterial cellulose/the shape of chitosan sponge dressing, length are not limited to shown in Fig. 1, its shape can design the arbitrary shape of applicable needs as required, length can be designed to as required such as with polypropylene nonwoven identical length or the length being slightly less than polypropylene nonwoven.
Embodiment 2
By the degree of polymerization 1000 bacteria cellulose film mass fraction 1%NaOH aqueous solution decocting in water 45min at 80 DEG C, then fully wash to neutral (pH=7.0) with distilled water, at 75 DEG C, carry out vacuum drying 12h.Length 5.5mm, specific surface area 600m is become with ball ball mill grinding
2the fine strip body of/g.
Chitosan sheet being placed in (mass fraction) acetic acid of 3%, leaving standstill more than 4 hours, being made into through stirring the chitosan solution that content is 3% (mass fraction).Add in chitosan solution by above-mentioned Bacterial cellulose fine strip body, addition is 10% of chitosan dry weight, standing and defoaming.
By the chitosan solution of above-mentioned interpolation Bacterial cellulose fine strip body, be poured in nappy, freezing 7-9h postlyophilization in-20 DEG C of refrigerators, obtains Bacterial cellulose/chitosan composite sponge.
Bacterial cellulose/chitosan composite sponge is bonded on the polypropylene nonwoven of breathable microporous by PUR, becomes Bacterial cellulose/chitosan composite sponge dressing.Bacterial cellulose/the shape of chitosan compound composite, length are not limited to shown in Fig. 1, its shape can design the arbitrary shape of applicable needs as required, length can be designed to as required such as with polypropylene nonwoven identical length or the length being slightly less than polypropylene nonwoven.
Embodiment 3
By bacteria cellulose film mass fraction 1%NaOH aqueous solution decocting in water 45min at 80 DEG C of the degree of polymerization 3000, then fully wash to neutral (pH=7.0) with distilled water, at 75 DEG C, carry out vacuum drying 12h.Length 9.5mm, specific surface area 400m is become with ball ball mill grinding
2the fine strip body of/g.
Chitosan sheet is placed in 1-butyl-3-methylimidazolium chloride [C
4mIM] in Cl, leave standstill more than 8 hours, be made into through stirring the chitosan solution that content is 9% (mass fraction).Add in chitosan solution by above-mentioned Bacterial cellulose fine strip body, addition is 20% of chitosan dry weight, standing and defoaming.
By the chitosan solution of above-mentioned interpolation Bacterial cellulose fine strip body, be poured in nappy, freezing 7-9h postlyophilization in-20 DEG C of refrigerators, obtains Bacterial cellulose/chitosan composite sponge.
Bacterial cellulose/chitosan composite sponge is bonded on the polypropylene nonwoven of breathable microporous by heat-sensitive glue, becomes Bacterial cellulose/chitosan composite sponge dressing.Bacterial cellulose/the shape of chitosan compound composite, length are not limited to shown in Fig. 1, its shape can design the arbitrary shape of applicable needs as required, length can be designed to as required such as with polypropylene nonwoven identical length or the length being slightly less than polypropylene nonwoven.
Claims (3)
1. Bacterial cellulose/chitosan composite sponge dressing, is characterized in that: described composite sponge dressing from top to bottom comprises successively: Bacterial cellulose/chitosan sponge layer (1), tack coat (2) and nonwoven layer (3); Described nonwoven layer (3) is polypropylene nonwoven, and polypropylene nonwoven has breathable microporous.
2. a kind of Bacterial cellulose/chitosan composite sponge dressing according to claim 1, is characterized in that: described tack coat (2) is binding agent.
3. a kind of Bacterial cellulose/chitosan composite sponge dressing according to claim 2, is characterized in that: described binding agent is PUR or heat-sensitive glue.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320674543.2U CN204158771U (en) | 2013-10-29 | 2013-10-29 | A kind of Bacterial cellulose/chitosan composite sponge dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320674543.2U CN204158771U (en) | 2013-10-29 | 2013-10-29 | A kind of Bacterial cellulose/chitosan composite sponge dressing |
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| Publication Number | Publication Date |
|---|---|
| CN204158771U true CN204158771U (en) | 2015-02-18 |
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| CN201320674543.2U Expired - Fee Related CN204158771U (en) | 2013-10-29 | 2013-10-29 | A kind of Bacterial cellulose/chitosan composite sponge dressing |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104963094A (en) * | 2015-07-08 | 2015-10-07 | 江南大学 | Non-woven cloth prepared by composite fibers by means of bacterial cellulose produced by microorganisms and preparation method thereof |
| CN105965636A (en) * | 2016-07-12 | 2016-09-28 | 南京林业大学 | Method for modifying wood and bamboo wood through biopolymer-chitosan |
| CN106178063A (en) * | 2016-08-14 | 2016-12-07 | 张天奇 | A kind of without immunologic rejection adhesive bandage |
| CN115807275A (en) * | 2021-09-13 | 2023-03-17 | 北京林业大学 | Medical antibacterial mask made of regenerated cellulose non-woven fabric and preparation method of medical antibacterial mask |
-
2013
- 2013-10-29 CN CN201320674543.2U patent/CN204158771U/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104963094A (en) * | 2015-07-08 | 2015-10-07 | 江南大学 | Non-woven cloth prepared by composite fibers by means of bacterial cellulose produced by microorganisms and preparation method thereof |
| CN105965636A (en) * | 2016-07-12 | 2016-09-28 | 南京林业大学 | Method for modifying wood and bamboo wood through biopolymer-chitosan |
| CN106178063A (en) * | 2016-08-14 | 2016-12-07 | 张天奇 | A kind of without immunologic rejection adhesive bandage |
| CN115807275A (en) * | 2021-09-13 | 2023-03-17 | 北京林业大学 | Medical antibacterial mask made of regenerated cellulose non-woven fabric and preparation method of medical antibacterial mask |
| CN115807275B (en) * | 2021-09-13 | 2024-05-24 | 北京林业大学 | Medical antibacterial mask made of regenerated cellulose non-woven fabric and preparation method thereof |
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