CN103285419B - Method for preparing medical wound repair material - Google Patents
Method for preparing medical wound repair material Download PDFInfo
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- CN103285419B CN103285419B CN201210045323.3A CN201210045323A CN103285419B CN 103285419 B CN103285419 B CN 103285419B CN 201210045323 A CN201210045323 A CN 201210045323A CN 103285419 B CN103285419 B CN 103285419B
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- chitin
- cream
- cera flava
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- beewax
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Abstract
The invention provides a method for preparing a medical wound repair material. The method comprises the following steps: soaking 1 to 5 parts of chitin in 90 to 95 parts of sesame oil for 20 to 24 hours; heating the sesame oil added with the chitin to 100 DEG C by using slow fire and maintaining for 20 to 30 minutes; filtering chitin sediment, and remaining the miscible substance of the chitin and the sesame oil; adding 1 to 5 parts of beewax into the miscible substance of the chitin and the sesame oil and mixing uniformly to fully melt the beewax; cooling the mixture to obtain the miscible substance of chitin beewax cream; and soaking medical non-woven gauze into the miscible substance of the chitin beewax cream, wherein the medical non-woven gauze stained with the miscible substance of the chitin beewax cream is the medical wound repair material. Compared with the prior art, the method for preparing the medical wound repair material has the advantages of 1, moisture retention property of a hydrophobic film; 2, partial bacteriostatic and nutritional properties; and 3, painless in dressing change.
Description
Technical field
The present invention relates to field of medical products, specifically a kind of method of preparing Medical wounded surface repair materials.
Background technology
Chitin is as a kind of natural macromolecular material; have another name called chitin, chitin; after acetylation, be called chitosan; it is a kind of linear aminopolysaccharide that maintains and protect crustacean and microorganism body; extensively be present in the wing or shell of arthropods, be also present in fungus and algae and starve in cell wall.Have scholar to prove that by experiment chitin makes impaired biological physical ability induce special cells abroad, wound healing, has antiinflammatory, hemostasis, analgesic property.Have and experimental results show that carapace have the effect of prevention tissue adhesion, minimizing cicatrization.
In the developed country such as American-European-Japanese, chitin material and derivant thereof are widely used in to medical sanitary field.As the operation suture thread of du pont company, after recovery, need not remove; US Patent No. 197322 is used non-weaving cloth the solution coatings that contains chitin/chitosan, the solution-treated of the non-woven after coating through containing alkali, and being present in chitosan in non-weaving cloth can slowly be absorbed by bioengineered tissue, thus Promote cell's growth.The medical materials such as immunopotentiating agent, absorbable sutures, artificial skin and wound dressing of manufacturing with chitin have been developed at present.Domestic have chitin is prepared into the aqueous solution saliva liquid film forming of living, or be prepared into powder or spun-laced nonwoven fabric etc. for medical wound.
Cera Flava sweet in the mouth, slightly warm in nature, has the effects such as astringent therapy sore, granulation promoting pain relieving.Han Xu etc. find by animal experimental observation, and the ointment made from Cera Flava can obviously improve the new capillary vessel quantity of chronic skin wound surface, improves wound surface microcirculation, acceleration of tissue repair process.Cera Flava can form at wound surface the hyaline membrane of one deck yellow, and wound surface is played to protection and moistening effect, has reduced the chance that antibacterial infects.Modern pharmacological research confirms that Oleum sesami is cool in nature sweet, and skin moistening itself has the effect of removing toxic substances and promoting granulation, can provide tissue growth needed nutritional labeling, improves chronic wound negative nitrogen balance, wound healing.Oil gauze is applied ointment or plaster can effectively prevent the evaporation of moisture after wound surface in wrapping, make wound surface keep certain humidity, in being similar under the condition of physiological environment, by undamaged liquefaction, get rid of slough, be conducive to the epithelial growth of wound surface, reduce cicatrization.Meanwhile, if be coated with wound surface outward with Oleum sesami, can reduce oozing out of wound surface, prevention infection, reduces gauze and skin wound adhesion, is conducive to the healing of wound surface.
But above material has certain weak point, some moisture retentions are inadequate, and some bacteriostasis are inadequate, and the Nutrition to wound having is poor, has affected the healing of wound.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of method of preparing Medical wounded surface repair materials, can effectively promote the healing of surface wound, for the application of clinical dressing provides more selection.
The present invention solves the problems of the technologies described above adopted technical scheme to be:
A method of preparing Medical wounded surface repair materials, adds 1～5 part of chitin in 90～95 parts of Oleum sesami and soaks 20-24 hour, with slow fire, is heated to 100 ℃, maintains 20-30 minute; Elimination chitin sediment, the immiscible material of reservation chitin and Oleum sesami; The immiscible material of described chitin and Oleum sesami is equipped with to 1～5 part of Cera Flava, and mix homogeneously all melts Cera Flava, obtains chitin Cera Flava cream immiscible material after cooling; Medical non-woven gauze is immersed to described chitin Cera Flava cream immiscible material, and the medical non-woven gauze that speckles with described chitin Cera Flava cream immiscible material is described Medical wounded surface repair materials.
The present invention compared with prior art, has the following advantages: 1, the moisture retention of hydrophobic film-forming, 2, local antibacterial and trophism, 3, the Silent Neuritis of changing dressings.
The specific embodiment
Below in conjunction with specific embodiment, the technical scheme in the present invention is clearly and completely described.
Embodiment 1
1 part of chitin is added in 94 parts of Oleum sesami and soaked 24 hours, and slow fire is heated to 100 ℃, maintains 30 minutes; Elimination chitin sediment, the immiscible material of reservation chitin and Oleum sesami; The immiscible material of described chitin and Oleum sesami is equipped with to 5 parts of Cera Flavas, and mix homogeneously all melts Cera Flava, obtains chitin Cera Flava cream immiscible material (being brown color) after cooling.Then medical non-woven gauze is immersed to described chitin Cera Flava cream immiscible material, the medical non-woven gauze that speckles with described chitin Cera Flava cream immiscible material is described Medical wounded surface repair materials, and packing is used cobalt-60 radiosterilization.
Embodiment 2
3 parts of chitins are added in 94 parts of Oleum sesami and soaked 22 hours, and slow fire is heated to 100 ℃, maintains 28 minutes; Elimination chitin sediment, the immiscible material of reservation chitin and Oleum sesami; The immiscible material of described chitin and Oleum sesami is equipped with to 3 parts of Cera Flavas, and mix homogeneously all melts Cera Flava, obtains chitin Cera Flava cream immiscible material (being brown color) after cooling.Then medical non-woven gauze is immersed to described chitin Cera Flava cream immiscible material, the medical non-woven gauze that speckles with described chitin Cera Flava cream immiscible material is described Medical wounded surface repair materials, and packing is used cobalt-60 radiosterilization.
Embodiment 3
5 parts of chitins are added in 90 parts of Oleum sesami and soaked 23 hours, and slow fire is heated to 100 ℃, maintains 25 minutes; Elimination chitin sediment, the immiscible material of reservation chitin and Oleum sesami; The immiscible material of described chitin and Oleum sesami is equipped with to 5 parts of Cera Flavas, and mix homogeneously all melts Cera Flava, obtains chitin Cera Flava cream immiscible material (being brown color) after cooling.Then medical non-woven gauze is immersed to described chitin Cera Flava cream immiscible material, the medical non-woven gauze that speckles with described chitin Cera Flava cream immiscible material is described Medical wounded surface repair materials, and packing is used cobalt-60 radiosterilization.
The embodiment of the present invention makes full use of the hydrophobicity of Cera Flava, Oleum sesami and the film property of chitin, can fully keep the environment of wound surface in approximate physiological status, has the moisture retention of hydrophobic film-forming, meets " wet union is theoretical " that Winter proposes.Oleum sesami contains abundant plant sterol, oleic acid, sub-acid etc., and for wound surface basal cell provides nutrient substance, the regeneration of active cell, has local trophism; Chitin has local antiinflammatory, bacteriostasis, and chitin Cera Flava cream Wound healing rate is increased, and has the effect of wound healing.The outer compress material of chitin Cera Flava has hydrophobicity and film forming moisture retention, the not sticky wound of dressing, and without the secondary damage of wound, while changing dressings, patient is not bitterly.
The chitin Cera Flava wound repair material treatment chronic wound that uses the embodiment of the present invention to prepare, has obtained satisfactory effect.Experimental research by rat shows, for chitin Cera Flava immiscible material provides theoretical foundation as Medical wounded surface repair materials.Institute's experimental technique is that the wound surface of rat back is divided into two groups: (1) left side is matched group (normal saline group); (2) right side is experimental group (chitin Cera Flava cream group, it uses chitin Cera Flava immiscible material for the embodiment of the present invention 1 method preparation), test 21 days, observe the healing state of wound surface, measure the content of matched group and experimental group wound tissue specimen epidermal growth factor (EGF), specifically referring to table 1 and table 2:
Table 1 different phase wound surface area and healing rate
Note: normal saline group and chitin Cera Flava are formed face Area comparison p < 0.01 (p < 0.05 has significant difference)
Table 2EGF assay result
Note: normal saline group and chitin Cera Flava are formed face Area comparison, #p > 0.05; * p < 0.01 (p < 0.05 has significant difference)
The result of experiment is that the wound surface Area comparison of experimental group and matched group significantly dwindles (P < 0.01), experimental group EGF increased content (51.375 ± 33.524pg/ml) in the time of the 7th day, be significantly higher than matched group EGF content (P=0.01 < 0.05), because the content of union of wounded skin and epidermal growth factor is proportionate, use chitin Cera Flava cream to be significantly higher than matched group EGF content, further should demonstrate,prove the effect that chitin Cera Flava wound repair material has wound healing.
The above; be only the specific embodiment of the present invention, but protection scope of the present invention is not limited to this, anyly belongs to those skilled in the art in the technical scope that the present invention discloses; the variation that can expect easily or replacement, within all should being encompassed in protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claim.
Claims (1)
1. a method of preparing Medical wounded surface repair materials, is characterized in that: 1～5 part of chitin is added in 90～95 parts of Oleum sesami and soaks 20-24 hour, with slow fire, be heated to 100 ℃, maintain 20-30 minute; Elimination chitin sediment, the immiscible material of reservation chitin and Oleum sesami; The immiscible material of described chitin and Oleum sesami is equipped with to 1～5 part of Cera Flava, and mix homogeneously all melts Cera Flava, obtains chitin Cera Flava cream immiscible material after cooling; Medical non-woven gauze is immersed to described chitin Cera Flava cream immiscible material, and the medical non-woven gauze that speckles with described chitin Cera Flava cream immiscible material is described Medical wounded surface repair materials.
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| CN201210045323.3A CN103285419B (en) | 2012-02-27 | 2012-02-27 | Method for preparing medical wound repair material |
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| CN201210045323.3A CN103285419B (en) | 2012-02-27 | 2012-02-27 | Method for preparing medical wound repair material |
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| CN103285419A CN103285419A (en) | 2013-09-11 |
| CN103285419B true CN103285419B (en) | 2014-12-10 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105107013B (en) * | 2015-09-09 | 2017-11-24 | 上海美宝生命科技有限公司 | A kind of floorboard with high oil content biological composite membrane and preparation method thereof |
| CN105664226A (en) * | 2016-03-30 | 2016-06-15 | 上海白衣缘生物工程有限公司 | Medical composite dressing and preparation method thereof |
| CN107441479B (en) * | 2017-08-08 | 2018-12-21 | 广东海洋大学 | Marine active peptide/chitin burn ointment for treating scald and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1410452A (en) * | 2002-11-26 | 2003-04-16 | 姜发堂 | Plant polysaccharide sponge body and its preparation method |
| CN1508353A (en) * | 2002-12-19 | 2004-06-30 | 全球生技股份有限公司 | Method for treating chitin for fiber antibacteria |
| CN1565533A (en) * | 2003-06-18 | 2005-01-19 | 东北林业大学 | Prescription of body surface shielding film and its preparing method |
| CN101220323A (en) * | 2007-01-09 | 2008-07-16 | 青岛大学 | Method for producing anhydrous oil removing cream |
| JP2009108018A (en) * | 2007-10-30 | 2009-05-21 | Bhn Kk | Ultraviolet resistivity enhancer and use thereof |
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2012
- 2012-02-27 CN CN201210045323.3A patent/CN103285419B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1410452A (en) * | 2002-11-26 | 2003-04-16 | 姜发堂 | Plant polysaccharide sponge body and its preparation method |
| CN1508353A (en) * | 2002-12-19 | 2004-06-30 | 全球生技股份有限公司 | Method for treating chitin for fiber antibacteria |
| CN1565533A (en) * | 2003-06-18 | 2005-01-19 | 东北林业大学 | Prescription of body surface shielding film and its preparing method |
| CN101220323A (en) * | 2007-01-09 | 2008-07-16 | 青岛大学 | Method for producing anhydrous oil removing cream |
| JP2009108018A (en) * | 2007-10-30 | 2009-05-21 | Bhn Kk | Ultraviolet resistivity enhancer and use thereof |
Non-Patent Citations (1)
| Title |
|---|
| 李炳辉等.甲壳素麻油蜂蜡膏促进糖尿病足创面愈合的研究进展.《中华损伤与修复杂志（电子版）》.2011,第6卷(第4期), * |
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