CN1565533A - Prescription of body surface shielding film and its preparing method - Google Patents

Prescription of body surface shielding film and its preparing method Download PDF

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Publication number
CN1565533A
CN1565533A CN 03132444 CN03132444A CN1565533A CN 1565533 A CN1565533 A CN 1565533A CN 03132444 CN03132444 CN 03132444 CN 03132444 A CN03132444 A CN 03132444A CN 1565533 A CN1565533 A CN 1565533A
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China
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solution
lactic acid
oil
chitin
tween
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CN 03132444
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CN1299704C (en
Inventor
祖元刚
付玉杰
郑春英
张宝友
赵文灏
王纪坤
杨逢建
于景华
祖柏实
侯春莲
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Northeast Forestry University
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Northeast Forestry University
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Publication of CN1299704C publication Critical patent/CN1299704C/en
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Abstract

The invention provides the prescription of body surface shielding film and its preparing method, wherein the prescription comprises Twain 80, sesame oil, oil of pine needles, glycerin, lactic acid, absolute ethyl alcohol, chitosan, and lactic acid solution, the preparing process is conducted at normal temperature with no need of heating and thermal insulation.

Description

Body surface protection liniment prescription and preparation technology
Affiliated technical field
The present invention relates to a kind of Chinese medicine, particularly a kind of prescription of body surface protection liniment and preparation technology.
Background technology
Membrane material is dissolved into (as polyvinyl formal-acetal with organic solvent in liniment system; Polyvinyl butyral resin, collodion etc.) and medicine and a kind of externally-used embrocation of making.Time spent is applied to the affected part, and solvent volatilization back forms thin film with the protection wound surface, discharges contained drug gradually simultaneously and plays therapeutical effect, for example treat neurodermatitis 0.5% hydrocortisone liniment, scald liniment, chilblain plaster etc.At present, aspect the self-protection research that stops (SARS) viral direct infection body surface and exposure portion body surface, the many approach of scientific and technical personnel both domestic and external from enhancing human body immunity, by nasal administration interferons medicine being stoped indirectly (SARS) viral infection respiratory tract, and can not be used for carrying out other exposure portion body surfaces, and even the sterilization of whole body body surface protection.China scientific and technical personnel develop with macromolecular material and are coated with the membranous type glove, only are confined to hand protection.U.S. scientific and technical personnel use chitosan and add antimicrobial component exploitation mold type medical accessory, but can not carry out the protection of effective closure formula to the exposure portion body surface.
Summary of the invention
The objective of the invention is to overcome the weak point that exists in the above-mentioned technology, a kind of prescription and preparation technology thereof that can effectively stop (SARS) viral direct infection exposure portion body surface, strong, nontoxic, the non-irritating body surface protection liniment of elasticity is provided.
In order to achieve the above object, the technical solution used in the present invention is:
The prescription of body surface protection liniment of the present invention is characterized in that (following each components based on weight percentage):
Tween (Tween 80) 2--10%, Ledum palustre L. var. dilatatum Wahl.oil 0.5--5%, pinke needle oil 0.2--6%, glycerol 0.3--5%, lactic acid 0.6--5%, dehydrated alcohol 2--10%, chitin 2--8%, lactic acid solution 60--90%.
The preparation technology of body surface protection liniment of the present invention is characterized in that:
A. get tween (Tween 80) and place beaker, add Ledum palustre L. var. dilatatum Wahl.oil, pinke needle oil, glycerol, lactic acid, dehydrated alcohol respectively and fully mix into the transparent volatile oil solution of yellowish-brown,
B. get chitin, add lactic acid solution, fully stirring and dissolving becomes the translucent chitin solution of milky,
C. the translucent chitin solution of milky is added in the transparent volatile oil solution of yellowish-brown, fully mix into faint yellow clear solution.
Advantage of the present invention:
1) body surface protection liniment, be convenient to smear, spread upon easy film forming on the skin, strong adhesion, the transparency of film are 98--99%, the thickness of film is 0.1--0.3mm, the anti-decomposability of film is 0.04--0.05%, and breathability is 0.4--0.5%, pH value 6.0--6.5, be applied to the refrigerant comfortable stingless excitation of skin surface, have no side effect.
2) the body surface protection liniment contains having of filtering out and presses down the active component that kills (SARS) virus and fowl coronavirus (IBV) and tool broad-spectrum sterilization effect from plant volatile oil, pressing down extremely, fowl coronavirus rate is 99.9%, sterilizing rate (escherichia coli, staphylococcus aureus, bacillus subtilis) is 99.9%, can effectively stop SARS virus direct infection exposure portion body surface.
3) membrane matrix is a chitin, and chitin itself just has antibiotic infection and antiviral effect.Chitin is tied sharp Yale Salmonella, Mus injury Salmonella and Liszt's monokaryon hypertrophy bacterium to staphylococcus aureus, escherichia coli, small intestinal, and stronger inhibitory action is all arranged.
4) preparation technology of body surface protection liniment carries out at normal temperatures, need not heat and be incubated, and operational process of craft is simple, convenient, less energy consumption, and safe and reliable, processing cost is low.Operating equipment is simple, easily forms the sterile working.
The specific embodiment
Below the invention process is described in further detail:
The prescription of body surface protection liniment of the present invention is characterized in that (following each components based on weight percentage):
Tween (Tween 80) 2--10%, Ledum palustre L. var. dilatatum Wahl.oil 0.5--5%, pinke needle oil 0.2--6%, glycerol 0.3--5%, lactic acid 0.6--5%, dehydrated alcohol 2--10%, chitin 2--8%, lactic acid solution 60--90%.
The preparation technology of body surface protection liniment of the present invention is characterized in that:
A. get tween (Tween 80) and place beaker, add Ledum palustre L. var. dilatatum Wahl.oil, pinke needle oil, glycerol, lactic acid, dehydrated alcohol respectively and fully mix into the transparent volatile oil solution of yellowish-brown,
B. get chitin, add lactic acid solution, fully stirring and dissolving becomes the translucent chitin solution of milky,
C. the translucent chitin solution of milky is added in the transparent volatile oil solution of yellowish-brown, fully mix into faint yellow clear solution.
The concentration of described lactic acid solution is 1--10%.
Example 1: tween (Tween 80) 5ml, Ledum palustre L. var. dilatatum Wahl.oil 0.6ml, pinke needle oil 0.4ml, glycerol 0.4ml, lactic acid 0.8ml, dehydrated alcohol 3ml, chitin 3g, lactic acid solution 87ml.
Get 5ml tween (Tween 80), add 0.6ml Ledum palustre L. var. dilatatum Wahl.oil, 0.4ml pinke needle oil, 0.4ml glycerol, 0.8ml lactic acid, 3ml dehydrated alcohol successively, fully stir, mix homogeneously promptly gets the transparent volatile oil solution of yellowish-brown.Take by weighing the 3g chitin and be dissolved in the 87ml lactic acid solution, fully stir, get the translucent chitin solution of milky until dissolving fully.The translucent chitin solution of milky is slowly poured in the transparent volatile oil solution of yellowish-brown, fully stirred up to forming clear solution.
Example 2: tween (Tween 80) 6ml, Ledum palustre L. var. dilatatum Wahl.oil 0.5ml, pinke needle oil 0.5ml, glycerol 0.5ml, lactic acid 0.8ml, dehydrated alcohol 3ml, chitin 2.5g, lactic acid solution 86ml.
Get 6ml tween (Tween 80), add 0.5ml Ledum palustre L. var. dilatatum Wahl.oil, 0.5ml pinke needle oil, 0.5ml glycerol, 0.8ml lactic acid, 3ml dehydrated alcohol successively, fully stir, mix homogeneously promptly gets the transparent volatile oil solution of yellowish-brown.Take by weighing the 2.5g chitin and be dissolved in the 86ml lactic acid solution, fully stir, get the translucent chitin solution of milky until dissolving fully.The translucent chitin solution of milky is slowly poured in the transparent volatile oil solution of yellowish-brown, fully stirred up to forming clear solution.
Example 3: tween (Tween 80) 6ml, Ledum palustre L. var. dilatatum Wahl.oil 0.6ml, pinke needle oil 0.5ml, glycerol 0.5ml, lactic acid 0.8ml, dehydrated alcohol 3ml, chitin 3.15g, lactic acid solution 87ml.
Get 6ml tween (Tween 80), add 0.6ml Ledum palustre L. var. dilatatum Wahl.oil, 0.5ml pinke needle oil, 0.5ml glycerol, 0.8ml lactic acid, 3ml dehydrated alcohol successively, fully stir, mix homogeneously promptly gets the transparent volatile oil solution of yellowish-brown.Take by weighing the 3.15g chitin and be dissolved in the 87ml lactic acid solution, fully stir, get the translucent chitin solution of milky until dissolving fully.The translucent chitin solution of milky is slowly poured in the transparent volatile oil solution of yellowish-brown, fully stirred up to forming clear solution.
Composite solution is the body surface protection liniment, and technical process is carried out at normal temperatures, operates fairly simple.Ledum palustre L. var. dilatatum Wahl.oil, pinke needle oil, glycerol are not soluble in water, add tween (Tween 80) and make itself and lactic acid, ethanol fully stir down the miscible transparent volatile oil solution of yellowish-brown that becomes.Chitin is dissolved in the lactic acid solution, fully stirs until forming the translucent chitin solution of milky.The translucent chitin solution of milky is poured in the transparent volatile oil solution of yellowish-brown, fully stirred till the solution that forms clear.
When the amount of tween (Tween 80) less than 2% the time, can not play adequately emulsified effect, greater than 10% o'clock, this product is not had obvious effect, raise the cost on the contrary.Ledum palustre L. var. dilatatum Wahl.oil, pinke needle oil are main inhibitory anti-virus compositions, and when content was lower than 0.5% and 0.2% respectively, the inhibitory anti-virus effect was not remarkable, and when content was higher than 5% and 6% respectively, though the inhibitory anti-virus effect strengthens, penetrating odor was excessive.Add glycerol and alleviated the crack after the film forming, increased the toughness of film.Chitin is a kind of film former, and it is water insoluble, diluted acid, and alkaline solution, is dissolved in concentrated acid solution, and content was less than 2% o'clock, and film property is poor, and content is higher than at 8% o'clock, and the liniment viscosity strengthens, and easily chaps after the film forming.
The key technical indexes of body surface protection liniment:
Press down the coronavirus rate of killing: 99.9%,
Sterilizing rate: 99.9%,
Film thickness: 0.1--0.3mm,
Film transparency: 98--99%,
Film breathability: 0.4--0.5%,
The anti-decomposability of film: 0.04--0.05%,
Film pH value: 6.0--6.5,

Claims (3)

1. the prescription of a body surface protection liniment is characterized in that (following each components based on weight percentage):
Tween (Tween 80) 2--10%, Ledum palustre L. var. dilatatum Wahl.oil 0.5--5%, pinke needle oil 0.2--6%, glycerol 0.3--5%, lactic acid 0.6--5%, dehydrated alcohol 2--10%, chitin 2--8%, lactic acid solution 60--90%.
2. the preparation technology of a body surface protection liniment is characterized in that:
A. get tween (Tween 80) and place beaker, add Ledum palustre L. var. dilatatum Wahl.oil, pinke needle oil, glycerol, lactic acid, dehydrated alcohol respectively and fully mix into the transparent volatile oil solution of yellowish-brown,
B. get chitin, add lactic acid solution, fully stirring and dissolving becomes the translucent chitin solution of milky,
C. the translucent chitin solution of milky is added in the transparent volatile oil solution of yellowish-brown, fully mix into faint yellow clear solution.
3. according to the prescription of claim 1 described body surface protection liniment, it is characterized in that: the concentration of described lactic acid solution is 1--10%.
CNB031324444A 2003-06-18 2003-06-18 Prescription of body surface shielding film and its preparing method Expired - Fee Related CN1299704C (en)

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CNB031324444A CN1299704C (en) 2003-06-18 2003-06-18 Prescription of body surface shielding film and its preparing method

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Application Number Priority Date Filing Date Title
CNB031324444A CN1299704C (en) 2003-06-18 2003-06-18 Prescription of body surface shielding film and its preparing method

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CN1565533A true CN1565533A (en) 2005-01-19
CN1299704C CN1299704C (en) 2007-02-14

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103285419A (en) * 2012-02-27 2013-09-11 李炳辉 Method for preparing medical wound repair material

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1345541A (en) * 2000-09-29 2002-04-24 徐永安 Sterilizing disinfectant

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103285419A (en) * 2012-02-27 2013-09-11 李炳辉 Method for preparing medical wound repair material
CN103285419B (en) * 2012-02-27 2014-12-10 李炳辉 Method for preparing medical wound repair material

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