CN1254278C - Medical ointment, film and tincture - Google Patents
Medical ointment, film and tincture Download PDFInfo
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- CN1254278C CN1254278C CN 01134884 CN01134884A CN1254278C CN 1254278 C CN1254278 C CN 1254278C CN 01134884 CN01134884 CN 01134884 CN 01134884 A CN01134884 A CN 01134884A CN 1254278 C CN1254278 C CN 1254278C
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Abstract
The present invention relates to an external and enepidermic material. A paste is prepared from polyvinyl butyral, glycerol, alcohol, etc., and different medicines are added into the paste body to obtain products with different efficiency. The present invention is characterized in that after the present invention is applied on skin or a wound, a layer of air permeable waterproof film which closely clings to the skin is formed to block dust and bacteria outside and provide medicines inside, and thus, the skin does not need binding by gauze and rubberized fabric. The present invention is used for treating scratches, skin pains, muscular pains, nerve pains and other diseases, and overcomes the disadvantage that enepidermic medicines are easy to rub off. When applied to a suture part, the present invention can prevent infection and bring convenience for observation without having skin allergy. When not used, the present invention can be torn down in sheet shapes. The present invention has the advantages of easy production and low cost.
Description
Patent of the present invention belongs to outer compress material, enepidermic category, relates to anti-inflammation and sterilization and treatment dermatosis, the dermapostasis of scuffing, scratch, knife injury, scald, burn, lumbago, muscular soreness, sprain, a kind of external preparation of contusion etc.
When skin be scratched, scratch, scald, when burning, a light antibiotic medicine of smearing, heavy debridement, coating, the lid gauze rubberized fabric wanted, even take medicine and have an injection.Practical for convenience, some products with comprehensive function arise at the historic moment, and " adhesive bandage ", " Bandaid " or the like are exactly wherein representational product.In addition " SHANGSHI ZHITONG GAO " to reach " dog skin plaster " or the like also be the product of using always.
This series products something in common must use exactly and mount backing material and binding material.Therefore it is not beautiful just to produce outward appearance, and skin is tauted, and causes shortcomings such as skin allergy, increase cost easily.
These product common drawback are coated on the skin is exactly rubbed easily, and the medicated clothing of making dirty lessens the curative effect.If the covering gauze then increases cost, be repugnant to the eye.
Suture for surgery all will cover the gauze rubberized fabric later on, perhaps wraps up with gauze.Could roll over gauze after two or three days and now examine the operation stitching situation, if wound dehiscence or suppuration are late.Very inconvenient.
Patent of the present invention " medical ointment, film " refers to a kind of like this material, and with " cream " or " ointment ", or the form of " gel " did not exist when it used.After it is coated on skin or the wound, just change into thin film, thereby we are referred to as " cream film " to the material that this " cream " can transform " film ".The effect that makes the cream film have medical treatment and prevent when our deisgn product is so be referred to as " medical ointment, film ".Because adopting ethanol is solvent, so called after " medical ointment, film and tincture ".
On the basis of hundreds of tests, this medical ointment, film and tincture has six distinctive features: it produces one deck microporous membrane at skin or wound surface (1), and air permeability and good and saturating warm nature are arranged.Life-time service does not have sultry sensation, can not cause skin allergy.(2) microporous membrane has suitable mechanical strength and elongation at break and skin is had suitable caking property, thereby can be with skin flexible and can not chap and be not easy " peeling ".Change dressings or can tear by slabbing once taking off gently no the time, very convenient.(3) microporous membrane externally stop antibacterial and dust invasion (the narrowest part of antibacterial surpasses 1 micron at least, and the aperture of microporous membrane has only the 0.1-0.9 micron, thus antibacterial can't be from micropore the front enter), internally slow releasing pharmaceutical plays therapeutical effect.Because microporous membrane is close to skin, can be so overcome antibacterial from the shortcoming of invasion wound in side, slit around the gauze.Overcome the shortcoming that the conventional process wound must use gauze, adhesive plaster or mount backing material and binding agent.(4) microporous membrane is close to skin surface, can not rubbed.Overcome the shortcoming that most skin medication (cream, ointment) is rubbed easily, improved enepidermic utilization rate.The medicated clothing of can not making dirty.(5) coat this product later at the surgical incision suture, not only anti-inflammation and sterilization prevention infection but also can see the wound healing situation at any time was convenient to timely processing.(6) area, shape and the thickness of medical ointment, film coating can free adjustment, do not have " dead angle ".(7) most of ointment, film and tincture adopts colourless or light material, has overcome to use to mount the shortcoming that backing material or gauze adhesive plaster are repugnant to the eye.(8) this layer film is more water-fast, is not easy to be washed by clear water.
The difference of patent of the present invention and other patent mainly contains three: (1) a lot of patents are filmogen with sodium polyacrylate, polyvinyl alcohol, sodium carboxymethyl cellulose etc., use gelatin as viscosifier and excipient.It is filmogen that patent of the present invention adopts polyvinyl butyral resin (PVB), so filmogen is different fully.(2) solvent difference: a lot of patents of invention all are solvent with water.Patent of the present invention is solvent with ethanol, plays pore-creating agent and disinfectant simultaneously.(3) in a lot of patents of invention, all to add the material that increases viscosity for the cohesive that improves material and skin.Not only do not add in the patent of the present invention, added the material that reduces viscosity on the contrary, reason is that the PVB and the skin that adopt in the patent of the present invention have too strong adhesive power, do not add " viscosity reductant " and is difficult to it is taken off from the skin slabbing.
Medical ointment, film and tincture mainly is made up of filmogen, solvent, auxiliary agent and medicine four parts.Reduce cost for simplifying prescription in patent of the present invention, adopt the principle of one-object-many-purposes, for example ethanol is solvent and pore-creating agent in this prescription, is again the anti-inflammation and sterilization agent.Glycerol is nutrient substance, plays reconciliation statement surface tension and moisture balance again.
Patent formulation branch of the present invention " basic recipe ", " special formulation " and " medical ointment, film " three part." basic recipe " and " special formulation " is meant the mastic that does not contain concrete medicine, adds certain medicine in " basic recipe " and " special formulation " lining and just becomes the medical ointment, film and tincture with given efficacy." basic recipe " is a prescription on a large scale that comprises " special formulation ", be mainly used in the addition medicine that difference is big greatly and in nature (particularly Chinese powder medicine and decoction liquor or extract), as long as suitably adjust at the ratio range that we provide, always can make a reasonable medical ointment, film and tincture of performance.For amount ratio less most of Western medicine or Chinese medicine purification thing, just can make mass ratio medical ointment, film and tincture preferably as long as adopt " special formulation " to add corresponding medicine again.
" basic recipe " is as follows: (weight ratio is applicable to Chinese powder medicine, the extractum of large usage quantity).
Polyvinyl butyral resin (PVB) 2-30 part
Glycerol 1-15 part
White oil 0.2-3 part
Ethanol (75%-100%) 80-120 part
Owing to may differ greatly on the pharmaceutical properties that is added and on the consumption, successfully prepare the consumption that corresponding ointment, film and tincture must suitably be regulated above-mentioned material,
" special formulation " following (being applicable to the most of Western medicine that consumption is less and the Chinese medicine of purification):
20 parts of polyvinyl butyral resins (PVB)
5 parts of glycerol
1 part of white oil
(80%) 100 part of ethanol
We adopt 80% ethanol in " special formulation ", and this is to make the dissolved least concentration of PVB, are again the upper limit concentration that makes ethanol performance sterilizing function, and this concentration helps adding various Chinese medicine ethanol extractions in the cream film, thus the expanded application scope.
Adding different medicines in " basic recipe " or " special formulation " just becomes and has the specific function medical ointment, film and tincture.
The medicine that uses in the medical ointment, film and tincture is divided into several classes of Western medicine and Chinese medicine and Chinese medicine extract.Below a few class medicines can be used as medicine and be added in the medical ointment, film and tincture: (1) anti-inflammation and sterilization medicine.(2) treat dermopathic medicine.(3) hemorrhage.(4) treatment muscular soreness, neuralgia, arthralgic medicine.(5) treat the medicine of spraining, dampening.The medicine of (6) treatment scald, burn.These medicines all have detailed introduction, no longer explanation here in pharmacopeia.
Below material can be used as auxiliary agent and be added to and go in the medical ointment, film and tincture to improve the performance of product: white oil, various edible oil, fatty glyceride, fatty acid, aliphatic alcohol, soap, sorbitol, Polyethylene Glycol, polyvinylpyrrolidone, methylcellulose, methylethylcellulose, hydroxypropyl cellulose, starch, modified starch, zinc oxide, Kaolin, silicon dioxide, xanthan gum, sodium alginate, sodium polyacrylate, polyacrylate and copolymer thereof.
The processing technology of medical ointment, film and tincture is as follows:
Polyvinyl butyral resin is added in the ethanol, standing over night, or stir until dissolving fully.Add glycerol and liquid paraffin, stir, so just obtained medical ointment, film and tincture by " basic recipe " or " special formulation " preparation.In the ointment, film and tincture of basic recipe or special formulation, add corresponding medicine (it is consistent that the concentration of adding and this medicine use in cream or ointment) medical ointment, film and tincture.
Medical ointment, film and tincture embodiment:
(1) anti-inflammation and sterilization ointment, film and tincture:
100 parts of ointment, film and tinctures by " special formulation " preparation
0.2 part of benzalkonium bromide
0.5 part of metronidazole (add or do not add)
(2) No. two anti-inflammation and sterilization ointment, film and tinctures:
Press 100 parts of the ointment, film and tinctures of embodiment 1 preparation
At least add following one or more medicine:
0.4 part in chloromycetin (add or do not add)
0.4 part in erythromycin (add or do not add)
0.5 part in sulfamethoxazole powder (add or do not add)
0.5 part of gentamycin (add or do not add)
(3) blood coagulation ointment, film and tincture:
100 parts of ointment, film and tinctures by " special formulation " preparation
15 parts of YUNNAN BAIYAO
(4) skin ointment film and tinctures (diclofenac paste film)
100 parts of ointment, film and tinctures by " special formulation " preparation
6 parts of diclofenac diethylammonium salt
1 part of azone (add or do not add)
(5) No. two skin ointment film and tinctures (inspiring confidence in fine jade cream film)
100 parts of ointment, film and tinctures by " special formulation " preparation
1 part of bifonazole
1 part of azone (add or do not add)
(6) No. three skin ointment film and tinctures (daktarin cream film)
100 parts of ointment, film and tinctures by " special formulation " preparation
2 parts of miconazole nitrates
1 part of azone (add or do not add)
(7) No. four skin ointment film and tinctures (encircling sharp cream film)
100 parts of ointment, film and tinctures by " special formulation " preparation
1 part of ciclopirox olamine
1 part of azone (add or do not add)
(8) No. five skin ointment film and tinctures (happy skin cream film)
100 parts of ointment, film and tinctures by " special formulation " preparation
0.1 part of halcinonide
1 part of azone (add or do not add)
(9) angina pectoris ointment, film and tincture
100 parts of ointment, film and tinctures by " special formulation " preparation
10 parts in nitroglycerine
1 part of azone (add or do not add)
(10) damp-affection and pain relieving ointment, film and tinctures
100 parts of ointment, film and tinctures by " special formulation " preparation
20 parts of methyl salicylate
2 parts of Borneolum Syntheticums
2 parts of Herba Menthaes
2 parts of Camphoras
1 part of azone (add or do not add)
5000 units of vitamin E (add or do not add)
1 part of vitamin B6 (add or do not add)
1 part of Semen daturae (add or do not add)
(11) No. two damp-affection and pain relieving ointment, film and tinctures
Press 100 parts of the ointment, film and tinctures of embodiment 10 preparation
10 parts of Chinese medicine (Olibanum, Myrrha, Cortex Cinnamomi, Flos Caryophylli, Rhizoma Kaempferiae) ethanol leaching things
(12) essential balm type ointment, film and tincture
100 parts of ointment, film and tinctures by " special formulation " preparation
6 parts of Mentholums
2 parts of Camphoras
2 parts of eucalyptus oils
1 part of eugenol
4 parts of Methyl Salicylates
1 part of white oil
1 part of azone (add or do not add)
(13) Flos Carthami oil type medical ointment, film and tincture:
100 parts of ointment, film and tinctures by " special formulation " preparation
15 parts of safflower oils (commercial goods)
1 part of azone (add or do not add)
We carry out hundreds of test to the relation of Mechanical Properties of Materials and structure and performance, comprehensive after, think that the actual effect of above-mentioned prescription is better.
We are at the application test that own and volunteer and animal (chicken and rabbit) last 2 years on one's body, and are respond well, do not have skin allergy and rejection phenomenon.For example, in when scratch, when mosquito bite staves skin, when on skin, pimple being arranged, when muscular soreness, when cutting rabbit skin and flesh a stream of blood, or the like, coat corresponding ointment, film and tincture, good result is all arranged.
Claims (7)
1. dermatologic ointment, film and tincture base material is characterized in that raw material weight percentage ratio is:
Polyvinyl butyral resin 2-30 part
Glycerol 1-15 part
Liquid paraffin 0.2-3 part
Ethanol (75%-100%) 80-120 part.
2. dermatologic tincture base material as claimed in claim 1, dermatologic ointment, film and tincture base material raw material weight is such as following:
Polyvinyl alcohol is compiled 20 parts of butyraldehyde
5 parts of glycerol
1 part of liquid paraffin
(80%) 100 part of ethanol.
3. dermatologic ointment, film and tincture base material as claimed in claim 2, the raw material weight of hemostasis ointment, film and tincture is such as following:
By 100 parts of the dermatologic ointment, film and tincture base materials of claim 2 preparation
15 parts of YUNNAN BAIYAO.
4. dermatologic ointment, film and tincture base material as claimed in claim 2, " diclofenac paste film and tincture " raw material weight is such as following:
By 100 parts of the dermatologic ointment, film and tincture base materials of claim 2 preparation
6 parts of diclofenac diethylammonium salt
1 part of azone (add or do not add)
Diclofenac diethylammonium salt is changed into 1 part of bifonazole, or 2 parts of miconazole nitrates, or 1 part of ciclopirox olamine, or 0.1 part of halcinonide, different dermatologic ointment, film and tinctures promptly become.
5. dermatologic ointment, film and tincture base material as claimed in claim 2, the raw material weight for the treatment of anginal dermatologic ointment, film and tincture is such as following:
By 100 parts of the dermatologic ointment, film and tincture base materials of claim 2 preparation
10 parts in nitroglycerine
1 part of azone (add or do not add)
6. as the dermatologic ointment, film and tincture base material of claim 2 preparation, the raw material weight of damp-affection and pain relieving ointment, film and tincture is such as following:
By 100 parts of the dermatologic ointment, film and tinctures of claim 2 preparation
20 parts of methyl salicylate
2 parts of Borneolum Syntheticums
2 parts of Herba Menthaes
2 parts of Camphoras
1 part of azone (add or do not add)
5000 units of vitamin E (add or do not add)
1 part of vitamin B6 (add or do not add)
1 part of Semen daturae (add or do not add)
7. dermatologic ointment, film and tincture base material as claimed in claim 2, the weight ratio of " Flos Carthami oil type ointment, film and tincture " raw material is as follows:
By 100 parts of the dermatologic ointment, film and tincture base materials of claim 2 preparation
15 parts of safflower oils
1 part of azone (add or do not add).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01134884 CN1254278C (en) | 2001-11-19 | 2001-11-19 | Medical ointment, film and tincture |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01134884 CN1254278C (en) | 2001-11-19 | 2001-11-19 | Medical ointment, film and tincture |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1419940A CN1419940A (en) | 2003-05-28 |
| CN1254278C true CN1254278C (en) | 2006-05-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01134884 Expired - Fee Related CN1254278C (en) | 2001-11-19 | 2001-11-19 | Medical ointment, film and tincture |
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| Country | Link |
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| CN (1) | CN1254278C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102274542A (en) * | 2011-08-30 | 2011-12-14 | 夏敬民 | Film-forming type waterproof breathable wound protecting liquid and preparation method thereof |
| CN103432159B (en) * | 2013-08-28 | 2015-07-22 | 武汉大正高科生物医药有限公司 | Nasal cavity air particle blocking agent, production method and application thereof |
| EP3253840B1 (en) * | 2015-02-06 | 2019-07-31 | Noven Pharmaceuticals, INC. | Pressure-sensitive adhesives for transdermal drug delivery |
| CN111700063B (en) * | 2020-06-29 | 2021-03-30 | 广州瑞铂茵健康科技有限公司 | Preservation method of umbilical cord specimen |
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2001
- 2001-11-19 CN CN 01134884 patent/CN1254278C/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| CN1419940A (en) | 2003-05-28 |
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