CN102274542A - Film-forming type waterproof breathable wound protecting liquid and preparation method thereof - Google Patents
Film-forming type waterproof breathable wound protecting liquid and preparation method thereof Download PDFInfo
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- CN102274542A CN102274542A CN2011102515028A CN201110251502A CN102274542A CN 102274542 A CN102274542 A CN 102274542A CN 2011102515028 A CN2011102515028 A CN 2011102515028A CN 201110251502 A CN201110251502 A CN 201110251502A CN 102274542 A CN102274542 A CN 102274542A
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Abstract
The invention relates to film-forming type waterproof breathable wound protecting liquid and a preparation method thereof. The wound protecting liquid may be of a coating type or an atomization film forming type and mainly consists of 50 to 140 grams of film-forming material, 530 to 850 grams of solvent, 10 to 30 grams of mixed pore forming agent and a preservative, wherein for the atomization film forming type, propellant is added. The preparation method comprises: adding the mixed pore forming agent into ethanol, and dissolving to obtain solution A; adding polyvinyl butyral into ethanol, expanding to obtain solution of polyvinyl butyral; adding the solution A into the expanded solution of polyvinyl butyral, and dissolving to obtain solution B; and filling and packing to obtain finished film-forming type wound protecting liquid, or pressing the solution B into the propellant which is a mixture of propane and butane to obtain the atomization film forming type wound protecting liquid. The wound protecting liquid is convenient for use and easy for observation, and can protect a wound face, promote crusta to form, isolate microorganisms, inhibit bacterial, and be waterproof and breathable; and after a transparent film is formed, the healing condition of the wound face can be observed at any time without changing medicine frequently.
Description
Technical field
The present invention relates to a kind of Wound-protection liquid and preparation method thereof, particularly relate to a kind of waterproof ventilating type that is coated with the gentle mist film-forming type of membranous type preparation form and protect the wound product, mainly belong to the surgical medical equipment technical field.
Background technology
Open wound comprises operative incision and burn; the processing of wound surface is behind debridement and suturing at present; adopt the antimicrobial antiphlogistic medicine to add dressing, wound medicine patch, medicine ointment, wound binding agent; this all has antimicrobial antiphlogistic and protecting wound surface effect preferably to wound, and some also has certain hemostasis, analgesic effect concurrently.But these products all come with some shortcomings, as the antibacterials drug resistance; Can not observe the wound healing situation at any time under the drug of topical application situation and need frequently change dressings, and when changing dressings, may cause the wound surface secondary damage; Drug of topical application position and easily come off by water-wet on every side and avoid washing is unfavorable for patient's body surface cleaning and is easy to infect; Toughness relatively poor and the restriction joint activity; Lack breathability and be unfavorable for oozing out more wound healing etc., these consequently influence wound healing and increase medical treatment cost.
During contracting, polyvinyl butyral contains long side chain, therefore it has toughness, flexibility and flexibility preferably, also has hydrophobicity thereby has waterproof action, pharmaceutically can serve as membrane material, but breathability is poor after its film forming, is unfavorable for the diffusion of medicine and oozes out the drying of more wound surface; Glycerol and polyvinylpyrrolidone are the hydrophilic macromolecule materials, in membrane material, can play water solublity pore effect, can play moisture-keeping function when wound surface is dry, glycerol also has antifreeze effect, polyvinylpyrrolidone film forming and prevent water evaporates and to cause wound surface over-drying when drying; Ethanol not only can be made solvent but also has disinfective action.But the compound formulation by these compositions is effectively used in protecting wound surface as yet.
Summary of the invention
The purpose of this invention is to provide a kind of liquid preparation of protecting the open wound surface of body surface; promptly be coated with the waterproof and breathable Wound-protection liquid of two kinds of dosage forms of the gentle mist type of membranous type; easy to use, the exact efficacy of this Wound-protection liquid; can promote crust to form, isolate microorganism, antibacterial, waterproof and ventilative. because of transparent after its film forming and have preferably toughness, stick and the avulsion performance; can observe the wound healing situation at any time and not need frequently to change dressings abarticular activity.
In order to address the above problem, the technical solution adopted in the present invention is:
A kind of film-forming type waterproof and breathable Wound-protection liquid mainly is made up of filmogen, solvent, mixing porogen and antiseptic, and each components contents is filmogen 50 grams ~ 140 grams, solvent 530 grams ~ 850 grams, porogen 10 grams ~ 30 grams; Described filmogen is a polyvinyl butyral, and its model is that viscosity is less than 350 CPS or less than 20 s; Described solvent is an ethanol, and its concentration is more than or equal to 95%; Described mixing porogen is polyvinylpyrrolidone and glycerol, and its part by weight is 1:1.26, and the specification of its polyvinylpyrrolidone is K15 ~ K30.
1. protect the liquid preparation that is coated with two kinds of dosage forms of the gentle mist film-forming type of membranous type of wound surface; Be coated with membranous type and comprise filmogen, solvent, mixing porogen and antiseptic, the aerosol film-forming type also comprises propellant being coated with on the basis of membranous type, the preparation 1000 the gram liniment raw materials consist of: polyvinyl butyral contract 70 the gram ~ 140 the gram, ethanol 760 grams ~ 850 grams, glycerol 8 grams ~ 16 grams, polyvinylpyrrolidone 7 grams ~ 14 grams, antiseptic is an amount of; The raw materials of preparation 1000 gram aerosol film-forming type preparations consist of: polyvinyl butyral 50 grams ~ 100 grams that contract, ethanol 530 grams ~ 600 grams, glycerol 5.6 grams ~ 11.2 grams, polyvinylpyrrolidone, 4.4 grams ~ 8.8 grams, third butane, 200 ~ 300 grams of 9:1.
2. protect the preparation method of the liquid preparation that is coated with two kinds of dosage forms of the gentle mist film-forming type of membranous type of wound surface, may further comprise the steps:
(1) take by weighing an amount of antiseptic, polyvinylpyrrolidone 7 grams ~ 14 grams, glycerol 8 grams ~ 16 grams, be taken up in order of priority to be added in 130 ~ 200 milliliters of ethanol, the limit edged stirs it is fully dissolved, and makes A liquid;
(2) take by weighing polyvinyl butyral 70 grams ~ 140 grams that contract, be added in 400 ~ 650 milliliters of ethanol, the limit edged stirs and to make its abundant swelling;
(3) A liquid is added to swollen polyvinyl butyral, add ethanol again to capacity, the limit edged stirs it is fully dissolved, and makes B liquid;
(4) with the B liquid fill that makes, packing promptly gets and is coated with membranous type Wound-protection liquid finished product;
(5) with the B liquid fill that makes, third butane, 200 ~ 300 grams that per 700 grams ~ 800 grams are pressed into 9:1 promptly get aerosol film-forming type Wound-protection liquid finished product.
3. usage and dosage
The cleaning wound surface is opened Packaging Bottle, Wound-protection liquid evenly is applied to (being coated with membranous type) or is sprayed on (aerial fog type) wound surface by the consumption of 0.2 milliliter ~ 0.5 milliliter of every sq, until 0.5 ~ 1 centimetre of wound surface edge normal skin, treats that its solvent evaporates film forming gets final product.
4. storage: put the shady and cool airtight preservation in place.
The present invention with respect to the beneficial effect of prior art is:
With existing general protecting wound surface dressing and external is more created plaster, ointment is compared, the present invention has following special performance:
(1) can promote crust to form, isolate microorganism, antibacterial and play effective protective effect to wound surface;
(2) waterproof and breathable both had been beneficial to the evaporation of oozing out more wound surface moisture, was beneficial to preserving moisture of dry wound surface again and promoted wound healing, did not also influence the bathing of cleaning around the wound surface;
(3) has preferably toughness and an abarticular activity;
(4) carry and easy to use, do not need other any dressing of external, be particularly suited for the emergent use of accident;
(5) transparent after the film forming, direct observation wound healing situation and do not need frequently to change dressings at any time;
(6) the plant tissue culture container closure has and isolates and suppress pathogenic bacteria, and is transparent and do not influence photosynthesis of plants, waterproof and breathable and be beneficial to the stable of culture environment; The grafting callus is not only shielded, and it has and prevents the influence of rainwater to callus.And easy to use, be easy to observe.
The specific embodiment
Below by embodiment the present invention is described in further details, these embodiment only are used for illustrating the present invention, do not limit the scope of the invention.
Embodiment 1
(1) a kind of coating film type waterproof and breathable Wound-protection liquid mainly is made up of filmogen, solvent, mixing porogen and antiseptic, and the weight of raw material of preparation liniment consists of: polyvinyl butyral 120 grams that contract, ethanol 830 grams, glycerol 12 grams, polyvinylpyrrolidone 10 grams, antiseptic is an amount of;
(2) preparation method of the coating film type waterproof and breathable Wound-protection liquid of protection wound surface may further comprise the steps:
1. take by weighing that antiseptic is an amount of, polyvinylpyrrolidone 10 grams, glycerol 12 grams, be taken up in order of priority to be added in 200 milliliters of ethanol, the limit edged stirs it is fully dissolved, and makes A liquid;
2. take by weighing polyvinyl butyral 120 grams that contract, be added in 600 milliliters of ethanol, the limit edged stirs and to make its abundant swelling;
3. A liquid is added to swollen polyvinyl butyral, add ethanol again to capacity, the limit edged stirs it is fully dissolved, and makes B liquid;
4. with the B liquid fill that makes, packing promptly gets and is coated with membranous type Wound-protection liquid finished product.
(3) usage and dosage
The cleaning wound surface is opened Packaging Bottle, by the consumption of 0.2 milliliter ~ 0.5 milliliter of every sq Wound-protection liquid evenly is applied to wound surface, until 0.5 ~ 1 centimetre of wound surface edge normal skin, treats that its solvent evaporates film forming gets final product.
(4) storage: put the shady and cool airtight preservation in place.
Embodiment 2
(1) a kind of aerosol film-forming type waterproof and breathable Wound-protection liquid, mainly form by filmogen, solvent, mixing porogen and antiseptic and propellant, the raw materials of preparation 1000 gram aerosol film-forming type preparations consist of: polyvinyl butyral 100 grams that contract, ethanol 600 grams, glycerol 11 grams, polyvinylpyrrolidone 8 grams, antiseptic is an amount of, the third butane propellant, 281 grams of 9:1.
(2) preparation method of the aerosol film forming waterproof and breathable Wound-protection liquid of protection wound surface may further comprise the steps:
1. take by weighing that antiseptic is an amount of, polyvinylpyrrolidone 9 grams, glycerol 11 grams, be taken up in order of priority to be added in 150 milliliters of ethanol, the limit edged stirs it is fully dissolved, and makes A liquid;
2. take by weighing polyvinyl butyral 100 grams, be added in 500 milliliters of ethanol, the limit edged stirs and makes its abundant swelling;
3. A liquid is added to swollen polyvinyl butyral, add ethanol again to capacity, the limit edged stirs it is fully dissolved, and makes B liquid;
4. with the B liquid fill that makes, packing promptly gets and is coated with membranous type Wound-protection liquid finished product;
5. with the B liquid fill that makes, third butane, 300 grams that per 700 grams are pressed into 9:1 promptly get aerosol film-forming type Wound-protection liquid finished product.
(3) usage and dosage
The cleaning wound surface is opened Packaging Bottle, by the consumption of 0.2 milliliter ~ 0.5 milliliter of every sq Wound-protection liquid evenly is sprayed on wound surface, until 0.5 ~ 1 centimetre of wound surface edge normal skin, treats that its solvent evaporates film forming gets final product.
(4) storage: put the shady and cool airtight preservation in place.
Claims (7)
1. film-forming type waterproof and breathable Wound-protection liquid, it is characterized in that: mainly be made up of filmogen, solvent, mixing porogen and antiseptic, each components contents is filmogen 50 grams ~ 140 grams, solvent 530 grams ~ 850 grams, mix porogen 10 grams ~ 30 grams, antiseptic is an amount of.
2. a kind of film-forming type waterproof and breathable Wound-protection liquid according to claim 1, it is characterized in that: described filmogen is a polyvinyl butyral, its model is that viscosity is less than 350 CPS or less than 20 s; Described solvent is an ethanol, and described mixing porogen is polyvinylpyrrolidone and glycerol, and its part by weight is 1:1.26, and the specification of its polyvinylpyrrolidone is K15 ~ K30.
3. a kind of film-forming type waterproof and breathable Wound-protection liquid according to claim 1 is characterized in that: described Wound-protection liquid is coated with two kinds of dosage forms of the gentle mist film-forming type of membranous type.
4. a kind of film-forming type waterproof and breathable Wound-protection liquid according to claim 3, it is characterized in that: the described membranous type that is coated with is made up of filmogen, solvent, mixing porogen and antiseptic, the raw material of preparation 1000 gram liniment consists of: filmogen 70 grams ~ 140 grams, solvent 760 grams ~ 850 grams, mix porogen 15 grams ~ 30 grams, antiseptic is an amount of.
5. a kind of film-forming type waterproof and breathable Wound-protection liquid according to claim 3, it is characterized in that: described aerosol film-forming type raw material consists of: the raw material of preparation 1000 gram aerosol film former consists of: filmogen 50 grams ~ 100 grams, solvent 530 grams ~ 600 grams, mix porogen 10 grams ~ 20 grams, antiseptic is an amount of, mixes propellant 200 ~ 300 grams; Mixing propellant is propane and butane, and its part by weight is 9:1.
6. a kind of film-forming type waterproof and breathable Wound-protection liquid according to claim 1 is characterized in that: this Wound-protection liquid is used for the sealing and the protection of grafting wound healing of protection, plant tissue culture container of people and animal body surface open wound except that eye.
7. the preparation method of the described film-forming type waterproof and breathable of claim 1 Wound-protection liquid is characterized in that: may further comprise the steps:
(1) taking by weighing an amount of antiseptic, 10 ~ 30 grams mixes and to cause the sky agent: polyvinylpyrrolidone and glycerol, to be taken up in order of priority to be added in 120 ~ 200 milliliters of ethanol, and the limit edged stirs and makes it abundant dissolving, makes A liquid;
(2) take by weighing 50 ~ 140 gram polyvinyl butyrals, be added in 400 ~ 640 milliliters of ethanol, the limit edged stirs and makes its abundant swelling, gets swollen polyvinyl butyral liquid;
(3) A liquid is added in the swollen polyvinyl butyral liquid, add ethanol again to capacity, the limit edged stirs it is fully dissolved, and makes B liquid;
(4) with the B liquid fill that makes, packing promptly gets and is coated with membranous type Wound-protection liquid finished product;
(5) with the B liquid fill that makes, per 700 grams are gone into third butane, 200 ~ 300 grams to 800 gram B hydraulic pressure, and packing promptly gets aerosol film-forming type Wound-protection liquid finished product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011102515028A CN102274542A (en) | 2011-08-30 | 2011-08-30 | Film-forming type waterproof breathable wound protecting liquid and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011102515028A CN102274542A (en) | 2011-08-30 | 2011-08-30 | Film-forming type waterproof breathable wound protecting liquid and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102772801A (en) * | 2012-08-10 | 2012-11-14 | 江苏长泰药业有限公司 | Wound spray for treating bruises and preparation method of wound spray |
| CN103157126A (en) * | 2012-03-26 | 2013-06-19 | 何星剑 | Woundplast glue and preparing method thereof |
| CN105288722A (en) * | 2015-11-13 | 2016-02-03 | 任宏 | Waterproof ventilating liquid adhesive bandage and preparation method thereof |
| CN105920649A (en) * | 2016-06-07 | 2016-09-07 | 东莞市万佳医疗科技有限公司 | Water-proof and breathable wound protecting material and preparation method thereof |
| CN106139240A (en) * | 2016-07-29 | 2016-11-23 | 江苏蓝湾生物科技有限公司 | A kind of preparation method of the Wound-protection liquid for treating skin ulcer |
| CN106139239A (en) * | 2016-07-12 | 2016-11-23 | 东莞市万佳医疗科技有限公司 | Full-service fluid dressing and preparation method thereof |
| CN106178096A (en) * | 2016-08-30 | 2016-12-07 | 张阳 | A kind of wound fluid film and preparation method thereof |
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| CN1419940A (en) * | 2001-11-19 | 2003-05-28 | 吴天祥 | Medical ointment, film and tincture |
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Patent Citations (2)
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| CN1419940A (en) * | 2001-11-19 | 2003-05-28 | 吴天祥 | Medical ointment, film and tincture |
| CN101337074A (en) * | 2008-08-05 | 2009-01-07 | 沈阳药科大学 | New use of polyvinylpyrrolidone in pharmacy |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103157126A (en) * | 2012-03-26 | 2013-06-19 | 何星剑 | Woundplast glue and preparing method thereof |
| CN102772801A (en) * | 2012-08-10 | 2012-11-14 | 江苏长泰药业有限公司 | Wound spray for treating bruises and preparation method of wound spray |
| CN102772801B (en) * | 2012-08-10 | 2014-10-15 | 江苏长泰药业有限公司 | Wound spray for treating bruises and preparation method of wound spray |
| CN105288722A (en) * | 2015-11-13 | 2016-02-03 | 任宏 | Waterproof ventilating liquid adhesive bandage and preparation method thereof |
| CN105920649A (en) * | 2016-06-07 | 2016-09-07 | 东莞市万佳医疗科技有限公司 | Water-proof and breathable wound protecting material and preparation method thereof |
| CN106139239A (en) * | 2016-07-12 | 2016-11-23 | 东莞市万佳医疗科技有限公司 | Full-service fluid dressing and preparation method thereof |
| CN106139240A (en) * | 2016-07-29 | 2016-11-23 | 江苏蓝湾生物科技有限公司 | A kind of preparation method of the Wound-protection liquid for treating skin ulcer |
| CN106178096A (en) * | 2016-08-30 | 2016-12-07 | 张阳 | A kind of wound fluid film and preparation method thereof |
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Application publication date: 20111214 |