CN102772801B - Wound spray for treating bruises and preparation method of wound spray - Google Patents
Wound spray for treating bruises and preparation method of wound spray Download PDFInfo
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- CN102772801B CN102772801B CN201210283814.1A CN201210283814A CN102772801B CN 102772801 B CN102772801 B CN 102772801B CN 201210283814 A CN201210283814 A CN 201210283814A CN 102772801 B CN102772801 B CN 102772801B
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Abstract
The invention provides a wound spray for treating bruises. The wound spray is composed of effect ingredients and a blank film formation stock solution, the effect ingredient are selected from one or more of external use disinfectants, external use antibiotics, local anesthetic and skin astringing ingredients, the blank film formation stock solution comprises polyvinyl butyral, a film formation auxiliary, a plastification viscosity-regulation agent, a surface active agent, a volatilization-assisted antisticking agent, a porogen, an aromatic and a solvent. The wound spray has the advantages that the film formation auxiliary is added so that formed films are more elastic; by means of the plastification viscosity-regulation agent, the regulated viscosity of the formed films is more suitable; by means of the volatilization-assisted antisticking agent, the volatilization of the stock solution is accelerated, and a spray valve is prevented from being blocked; and by means of combined actions of the ingredients, the wound spray is good in bactericidal effects and bioadhesive performances and capable of accelerating wound healing, ventilating wounds, preventing bacteria, inhibiting the bacteria and wetting the wounds.
Description
Technical field
The present invention relates to a kind of can be used for abrading treatment and at the wound spray of the rapid film forming of abrasion, belong to field of medical technology.
Background technology
Skin abrasion is the very common wound of one, be violence with skin be tangent line position contact due to damage, particularly palm, ancon, knee, shank, buccal etc. are located the most easily to cause injury, wound surface differs in size.Visible epidermis breakage after scratch, wound surface presents pale asphyxia, and has many little petechias and tissue fluid to ooze out, and some wounds can be dark and subcutaneous, causes the damage of skin holostrome.The wound surface forming after skin damage easily causes infection suppurates as malpractice, does not prolongedly heal, and forms cicatrix, or local pigmentation.Therefore how to handle wound well and promote wound and wound surface heals as early as possible, reduce to greatest extent or avoid the expansion of wound surface and infection to increase the weight of, and avoid the cicatrization after wound healing, to be engaged in the problem that treatment of wounds medical personnel pays close attention to and studies for many years always, the mode of conventional wrapping is treated at present, its advantage is that wound surface can normal healing under glitch-free environment, but occlusive dressing is used for juxta-articular wound, because joint part mobility is large, the chance being rubbed is many, makes wound be difficult to healing.
Adhesive bandage, " styptic plaster " is otherwise known as.Generally can only be used for neatly clean, hemorrhage few and don't minor cut or wound that needs are sewed up of comparatively shallow table, wound, play temporary transient hemostasis, protect the effect of wound surface.In life, we often can use adhesive bandage, particularly minor cut or wound, have gone out a blood, and often all think and paste an adhesive bandage with regard to everything is just fine, be not right in fact like this.Water absorption and the aeration of adhesive bandage itself are poor, are unfavorable for the drain of wound secretions, and the anti-growth and breeding that is beneficial to antibacterial makes wound and skin whitening around, deliquescing, causes supervention to infect.And adhesive bandage in tearing from wound because the effect of pressure sensitive adhesive above can make newborn epidermal laceration hold, cause patient to produce pain.In order to overcome the shortcoming of traditional adhesive bandage; there is now liquid adhesive bandage; and select the method for spraying to be injected in rapidly wound; form film body in wound surface fast; play protection wound and avoid the impact of extraneous factor, and film body is frivolous, non-stimulated; well do not come off with the adhesiveness of skin, the effect of absorptive tissue penetrating fluid.
Chinese patent CN201010200561.8 improves for existing film technique, has announced a kind and has prepared improving one's methods of liquid adhesive bandage.This patent exists following weak point: spray former fluid viscosity and surface tension are higher, are not suitable for press type sprayer unit; And after liquid adhesive bandage volatile solvent fully volatilizees, this liquid adhesive bandage film body is drier; Film body poor flexibility; After using sprayer unit, easily stop up shower nozzle; Film body is without ventilative pore effect.These unfavorable factors are very disadvantageous to the healing of wound, because wound healing rate in the situation that moistening is ventilative is the several times in dry and/or airtight situation.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art part, provide one to be used for the treatment of abrasive wound spray and preparation method thereof.
Of the present inventionly be used for the treatment of abrasive wound spray, formed by functional component and blank film forming stock solution, said functional component is selected from one or more in disinfectant for external use, topical antibiotic, local anesthetic and skin contraction composition, and said blank film forming stock solution comprises polyvinyl butyral, coalescents, plasticising adjusting adhesive, surfactant, helps volatilization antiplastering aid, porogen, aromatic and solvent;
Each composition shared mass percent in wound spray is as follows:
Said disinfectant for external use is selected from polymer, acrylic disulfide or the acrylic trithioether of benzalkonium chloride, benzalkonium bromide, iodine, iodine; Said topical antibiotic is selected from mupirocin, erythromycin or griseofulvin; Said local anesthetic is lignocaine, procaine, tetracaine, bupivacaine, ropivacaine or ibuprofen; Said skin contraction composition is selected from tannic acid, silver nitrate or zinc sulfate.
Said coalescents is ethyl cellulose; Said plasticising adjusting adhesive is selected from ethyl oleate, triethyl citrate, diethyl phthalate, dimethyl phthalate, dibutyl phthalate or silicone oil and derivant thereof; Said surfactant is sodium lauryl sulphate; Said help volatilization antiplastering aid be isobutyltrimethylmethane.; Said porogen is polyvinylpyrrolidone-vinyl acetate co-polymer or polyvinylpyrrolidone; Said aromatic is rose essence, Flos Jasmini Sambac Oleum sesami, wintergreen oil, Oleum menthae or Eucalyptus oil; Said solvent is one or several in ethanol, ethyl acetate, acetone, propylene glycol.
The preparation method that is used for the treatment of abrasive wound spray of the present invention, is characterized in that, comprises the steps:
1) functional component is pre-prepared: the functional component, aromatic, porogen, the surfactant that take recipe quantity are mixed
Close evenly, add appropriate solvent, for subsequent use after fully disperseing in high speed homogenization dispersion machine;
2) blank film forming stock solution preparation: take recipe quantity polyvinyl butyral, plasticising adjusting adhesive, coalescents,
Help volatilization antiplastering aid mix homogeneously, add the solvent of surplus, mix homogeneously, dissolves it completely;
3) by reserve liquid and the step 2 of step 1)) the abundant mix homogeneously of blank film forming stock solution, and pour into spraying
In device and get final product.
In the present invention,
Polyvinyl butyral resin is not the general designation of the condensation product of polyvinyl alcohol and various aldehydes, is a kind of ideal filmogen of alcohol dissolubility, has good elasticity, toughness, nonpoisonous and tasteless, contaminated, to outstanding character such as skin do not stimulate.
Ethyl cellulose is to be called for short EC, generally water insoluble, and be dissolved in different organic solvents, Heat stability is good, when burning, ash is extremely low, seldom there is adhesion sense or astringent, can generate tough and tensile thin film, in the time of low temperature, still can keep flexibility, this product is nontoxic, have extremely strong antibiont performance, metabolism inertia, in this product for helping the material of film forming.
Ethyl oleate (Ethyl Oleate), for the preparation of surfactant and other organic chemicals, also as spice, is mainly used in plasticization, the adjusting viscosity of this product.
Triethyl citrate, triethyl citrate, diethyl phthalate, dimethyl phthalate, dibutyl phthalate are all used as the plasticizer as adhesive and sealant, are mainly used in plasticization, the adjusting viscosity of this product.
Silicone oil and derivant thereof have many properties, coefficient as sticky in temperature is little, high-low temperature resistant, antioxidation, flash-point is high, volatility is little, good insulating, surface tension are little, corrosion-free, nontoxic etc. to metal.Due to these characteristics, silicone oil has remarkable effect in many aspects with application, is mainly used in plasticization, the adjusting viscosity of this product.
Sodium lauryl sulphate is a kind of white or faint yellow micro-sticky thing, is industrially usually used in detergent and textile industry.Belong to anion surfactant.Soluble in water, compatibility is good again with anion, nonionic, has good emulsifying, foaming, infiltration, decontamination and dispersive property, can effectively reduce surface tension.
Isobutyltrimethylmethane. is a kind of colourless transparent liquid.Be dissolved in benzene,toluene,xylene, chloroform, ether, Carbon bisulfide, carbon tetrachloride, dimethyl formamide and fall Oleum Ricini oils in addition, be slightly soluble in dehydrated alcohol, water-soluble hardly, help volatilization and assist the low viscous effect of falling.
Vinyl pyrrolidone/vinyl acetate co-polymer is also a kind of ideal filmogen of alcohol dissolubility, have well nonpoisonous and tasteless, to skin do not stimulate, not contaminated, with contact skin closely, the easy outstanding character such as natural degradation.
Polyvinylpyrrolidone (polyvinyl pyrrolidone) is called for short PVP, a kind of ideal filmogen of alcohol dissolubility, it is a kind of non-ionic macromolecule compound, most characteristic in N vinylamide polymer, and be studied the most deeply, fine chemicals kind widely.There is colloid protective effect, film property, caking property, hygroscopicity, solubilising or cohesion, but it is most characteristic, thus be subject to people pay attention to be its excellent solubility property and physiological compatibility.
Rose essence, jasmine Oleum sesami, Eucalyptus oil, wintergreen oil, Oleum menthae are mainly used in regulating the fragrance of this product.
Ethyl acetate, ethanol, acetone, propylene glycol are all good volatile solvents, and ethyl acetate has fruit aroma, are the aromatic of this spray.
Wound spray of the present invention has following technique effect:
1), by adding coalescents, make its more high resilience of film body becoming;
2) it is more applicable that plasticising adjusting adhesive makes the viscosity adjustment of its film body becoming;
3) help volatilization antiplastering aid can accelerate the volatilization of stock solution, prevent that spray valve from stopping up;
4) various composition combineds effect make the spray of the present invention can accelerating wound, have better bactericidal effect, more ventilative, fungi-proofing, antibacterial, bioadhesive is good, can moistening wound.
Brief description of the drawings
The injured situation map of scratch mark when Fig. 1 is the product of uncoated embodiment 1;
Fig. 2 is scratch mark incrustation situation map after product in use embodiment 1 after 1 day; As can be seen from Figure 2, healing rate is obviously accelerated, and infects without antibacterial;
Fig. 3 be after 5 days scratch mark use in embodiment 1 after product recovery from illness situation map; As can be seen from Figure 3, skin is completely recovered;
Fig. 4 is the wound wound face figure of the product of uncoated embodiment 1;
Fig. 5 is the design sketch being coated with on wound after the product of embodiment 1; As can be seen from Figure 5, coating is even, and the compatibility of skin is good, nonirritant;
After Fig. 6 is 1 day, the wound surface design sketch after the product film body of embodiment 1 is lifted; Skin does not infect as can be seen from Figure 6, there is no red and swollen phenomenon.Further illustrating this product has good hydrophobicity, and biocompatibility is non-stimulated to wound, without anaphylaxis, can well protect wound.
Detailed description of the invention
Listed embodiment is for being all weight percentage.Wherein PVB is that polyvinyl butyral, EC are that ethyl cellulose, VA64 are vinyl pyrrolidone-vinyl acetate co-polymer, and PVP is polyvinylpyrrolidone.
Embodiment 1
Component and the percentage by weight of the wound spray of the present embodiment are as follows:
Preparation technology is as follows:
(1) functional component is pre-prepared: take benzalkonium chloride, rose essence, VA64, the sodium lauryl sulphate mix homogeneously of recipe quantity, add appropriate ethanol, and for subsequent use after fully disperseing in high speed homogenization dispersion machine.
(2) blank film forming stock solution preparation: take PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously, dissolves it completely.
(3) step reserve liquid and the step abundant mix homogeneously of blank film forming stock solution (2) (1), and pour into the liquid adhesive bandage that obtains the benzalkonium chloride that contains 0.2% in sprayer unit.
Embodiment 2
Component and the percentage by weight of the wound spray of the present embodiment are as follows:
Preparation technology is as follows:
(1) functional component is pre-prepared: take benzalkonium bromide, Flos Jasmini Sambac Oleum sesami, VA64, the sodium lauryl sulphate mix homogeneously of recipe quantity, add appropriate ethyl acetate, and for subsequent use after fully disperseing in high speed homogenization dispersion machine.
(2) blank film forming stock solution preparation: take PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously, dissolves it completely.
(3) step reserve liquid and the step abundant mix homogeneously of blank film forming stock solution (2) (1), and pour into the liquid adhesive bandage that obtains the benzalkonium bromide that contains 0.2% in sprayer unit.
Embodiment 3
Component and the percentage by weight of the wound spray of the present embodiment are as follows:
Preparation technology is as follows:
(1) functional component is pre-prepared: take lecithin iodine, Eucalyptus oil, VA64, the sodium lauryl sulphate mix homogeneously of recipe quantity, add appropriate acetone, and for subsequent use after fully disperseing in high speed homogenization dispersion machine.
(2) blank film forming stock solution preparation: take PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously, dissolves it completely.
(3) step reserve liquid and the step abundant mix homogeneously of blank film forming stock solution (2) (1), and pour into the liquid adhesive bandage that obtains the lecithin iodine that contains 0.2% in sprayer unit.
Embodiment 4
Component and the percentage by weight of the wound spray of the present embodiment are as follows:
Preparation technology is as follows:
(1) functional component is pre-prepared: take acrylic acid disulfide, Oleum menthae, PVP, the sodium lauryl sulphate mix homogeneously of recipe quantity, add appropriate propylene glycol, and for subsequent use after fully disperseing in high speed homogenization dispersion machine.
(2) blank film forming stock solution preparation: take PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously, dissolves it completely.
(3) step reserve liquid and the step abundant mix homogeneously of blank film forming stock solution (2) (1), and pour into the liquid adhesive bandage that obtains the acrylic acid disulfide that contains 0.2% in sprayer unit.
Embodiment 5
Component and the percentage by weight of the wound spray of the present embodiment are as follows:
Preparation technology is as follows:
(1) functional component is pre-prepared: take acrylic acid trithioether, wintergreen oil, pvp, the sodium lauryl sulphate mix homogeneously of recipe quantity, add appropriate ethanol, and for subsequent use after fully disperseing in high speed homogenization dispersion machine.
(2) blank film forming stock solution preparation: take PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously, dissolves it completely.
(3) step reserve liquid and the step abundant mix homogeneously of blank film forming stock solution (2) (1), and pour into the liquid adhesive bandage that obtains the acrylic acid trithioether that contains 0.2% in sprayer unit.
Embodiment 6
Component and the percentage by weight of the wound spray of the present embodiment are as follows:
Preparation technology is as follows:
(1) functional component is pre-prepared: take mupirocin, Flos Jasmini Sambac Oleum sesami, pvp, the sodium lauryl sulphate mix homogeneously of recipe quantity, add appropriate ethanol, and for subsequent use after fully disperseing in high speed homogenization dispersion machine.
(2) blank film forming stock solution preparation: take PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously, dissolves it completely.
(3) step reserve liquid and the step abundant mix homogeneously of blank film forming stock solution (2) (1), and pour into the liquid adhesive bandage that obtains the mupirocin that contains 2% in sprayer unit.
Embodiment 7
Component and the percentage by weight of the wound spray of the present embodiment are as follows:
Preparation technology is as follows:
(1) functional component is pre-prepared: take erythromycin, Herba Menthae Oleum sesami, VA64, the sodium lauryl sulphate mix homogeneously of recipe quantity, add appropriate ethanol, and for subsequent use after fully disperseing in high speed homogenization dispersion machine.
(2) blank film forming stock solution preparation: take PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously, dissolves it completely.
(3) step reserve liquid and the step abundant mix homogeneously of blank film forming stock solution (2) (1), and pour into the liquid adhesive bandage that obtains the erythromycin that contains 5% in sprayer unit.
Embodiment 8
Component and the percentage by weight of the wound spray of the present embodiment are as follows:
Preparation technology is as follows:
(1) functional component is pre-prepared: take griseofulvin, rose essence, VA64, the sodium lauryl sulphate mix homogeneously of recipe quantity, add appropriate ethanol, and for subsequent use after fully disperseing in high speed homogenization dispersion machine.
(2) blank film forming stock solution preparation: take PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously, dissolves it completely.
(3) step reserve liquid and the step abundant mix homogeneously of blank film forming stock solution (2) (1), and pour into the liquid adhesive bandage that obtains the griseofulvin that contains 3% in sprayer unit.
Embodiment 9
Component and the percentage by weight of the wound spray of the present embodiment are as follows:
Preparation technology is as follows:
(1) functional component is pre-prepared: take lignocaine, rose essence, VA64, the sodium lauryl sulphate mix homogeneously of recipe quantity, add appropriate ethanol, and for subsequent use after fully disperseing in high speed homogenization dispersion machine.
(2) blank film forming stock solution preparation: take PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously, dissolves it completely.
(3) step reserve liquid and the step abundant mix homogeneously of blank film forming stock solution (2) (1), and pour into the liquid adhesive bandage that obtains the lignocaine that contains 3% in sprayer unit.
Embodiment 10
Component and the percentage by weight of the wound spray of the present embodiment are as follows:
Preparation technology is as follows:
(1) functional component is pre-prepared: take tannic acid, benzalkonium chloride, Herba Menthae Oleum sesami, VA64, the sodium lauryl sulphate mix homogeneously of recipe quantity, add appropriate ethanol, and for subsequent use after fully disperseing in high speed homogenization dispersion machine.
(2) blank film forming stock solution preparation: take PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously, dissolves it completely.
(3) step reserve liquid and the step abundant mix homogeneously of blank film forming stock solution (2) (1), and pour in sprayer unit and obtain and contain 0.5% tannic acid, the liquid adhesive bandage of 0.2% benzalkonium chloride.
Embodiment 11
Component and the percentage by weight of the wound spray of the present embodiment are as follows:
Preparation technology is as follows:
(1) functional component is pre-prepared: take silver nitrate, mupirocin, lignocaine, Herba Menthae Oleum sesami, VA64, the sodium lauryl sulphate mix homogeneously of recipe quantity, add appropriate ethanol, and for subsequent use after fully disperseing in high speed homogenization dispersion machine.
(2) blank film forming stock solution preparation: take PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously, dissolves it completely.
(3) step reserve liquid and the step abundant mix homogeneously of blank film forming stock solution (2) (1), and pour into the liquid adhesive bandage that obtains the silver nitrate, 2% mupirocin and 3% lignocaine that contain 0.5% in sprayer unit.
Embodiment 12
Component and the percentage by weight of the wound spray of the present embodiment are as follows:
Preparation technology is as follows:
(1) functional component is pre-prepared: take recipe quantity zinc sulfate, erythromycin, lignocaine, Herba Menthae Oleum sesami, VA64,
Sodium lauryl sulphate mix homogeneously, adds appropriate ethanol, for subsequent use after fully disperseing in high speed homogenization dispersion machine.
(2) blank film forming stock solution preparation: the PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate that take recipe quantity are mixed
Close evenly, add the solvent of surplus, mix homogeneously, dissolves it completely.
(3) step reserve liquid and the step abundant mix homogeneously of blank film forming stock solution (2) (1), and pour in sprayer unit
Must contain the liquid adhesive bandage of 0.5% zinc sulfate, 5% erythromycin and 3% lignocaine.
Embodiment 13
Component and the percentage by weight of the wound spray of the present embodiment are as follows:
Preparation technology is as follows:
(1) functional component is pre-prepared: take procaine, rose essence, VA64, the sodium lauryl sulphate mix homogeneously of recipe quantity, add appropriate ethanol, and for subsequent use after fully disperseing in high speed homogenization dispersion machine.
(2) blank film forming stock solution preparation: take PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously, dissolves it completely.
(3) step reserve liquid and the step abundant mix homogeneously of blank film forming stock solution (2) (1), and pour into the liquid adhesive bandage that obtains the procaine that contains 2% in sprayer unit.
Embodiment 14
Component and the percentage by weight of the wound spray of the present embodiment are as follows:
Preparation technology is as follows:
(1) functional component is pre-prepared: take tetracaine, jasmine Oleum sesami, VA64, the sodium lauryl sulphate mix homogeneously of recipe quantity, add appropriate ethanol, and for subsequent use after fully disperseing in high speed homogenization dispersion machine.
(2) blank film forming stock solution preparation: take PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously, dissolves it completely.
(3) step reserve liquid and the step abundant mix homogeneously of blank film forming stock solution (2) (1), and pour into the liquid adhesive bandage that obtains the tetracaine that contains 2.5% in sprayer unit.
Embodiment 15
Component and the percentage by weight of the wound spray of the present embodiment are as follows:
Preparation technology is as follows:
(1) functional component is pre-prepared: take bupivacaine, rose essence, VA64, the sodium lauryl sulphate mix homogeneously of recipe quantity, add appropriate ethanol, and for subsequent use after fully disperseing in high speed homogenization dispersion machine.
(2) blank film forming stock solution preparation: take PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously, dissolves it completely.
(3) step reserve liquid and the step abundant mix homogeneously of blank film forming stock solution (2) (1), and pour into the liquid adhesive bandage that obtains the bupivacaine that contains 4% in sprayer unit.
Embodiment 16
Component and the percentage by weight of the wound spray of the present embodiment are as follows:
Preparation technology is as follows:
(1) functional component is pre-prepared: take ropivacaine, ibuprofen, rose essence, VA64, the sodium lauryl sulphate mix homogeneously of recipe quantity, add appropriate ethanol, and for subsequent use after fully disperseing in high speed homogenization dispersion machine.
(2) blank film forming stock solution preparation: take PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously, dissolves it completely.
(3) step reserve liquid and the step abundant mix homogeneously of blank film forming stock solution (2) (1), and pour into and in sprayer unit, obtain the liquid adhesive bandage that contains 3% ropivacaine, 1% ibuprofen.
Embodiment 17
1, film body elasticity research
Formula is in table 1, and percentage ratio is mass percent (wherein PVB is polyvinyl butyral, and PVA is polyvinyl alcohol) described in following table
process for preparation is as follows:
1) preparation of ethyl cellulose: the ethyl cellulose of recipe quantity is fully swelling, for subsequent use in appropriate alcoholic solution.
2) preparation of polyvinyl alcohol: the polyvinyl alcohol of recipe quantity is fully swelling, for subsequent use in suitable quantity of water.
3) prescription 1 and contrast 1 preparation: the ethyl cellulose solution mix homogeneously that the polyvinyl butyral of recipe quantity, ethyl oleate, isobutyltrimethylmethane., step 1) are made, adds the ethanol of surplus, fully dissolving and get final product.
4) prescription 2 and contrast 2 preparation: the ethyl cellulose solution that the swelling solution of the polyvinyl alcohol of the ethyl oleate of recipe quantity, isobutyltrimethylmethane., step 1 0588 and step 1) are made, adds the second alcohol and water of surplus, fully dissolving and get final product.
5) prescription 3 and contrast 3 preparation: the ethyl cellulose solution that the swelling solution of the polyvinyl alcohol of the ethyl oleate of recipe quantity, isobutyltrimethylmethane., step 1 1788 and step 1) are made, adds the second alcohol and water of surplus, fully dissolving and get final product.
detection method is as follows:
By the film forming stock solution of prescription 1-3 and contrast 1-3, take out in 2 grams of rectangle glass boxes of pouring interior long 2cm inner width 0.8cm into, at room temperature place after 2 hours, make film forming complete.Take out film body, prune film body edge with blade and make its growth 1.8cm, the thin slice of wide 0.6cm, and be entirely placed on sheet glass, one is fixed on graduated sheet glass edge, and an effect of removing pulling force after stretching 1 minute with the pulling force of 20N, 40N, 60N respectively recovers after 5 minutes it, measures respectively the film body length before and after stretching, observe the deformation of film body, and measure the Flexible change rate of film.The results are shown in Table 2:
Can find out from the contrast of above-mentioned prescription 1-3 and contrast side 1-3,
1), by adding ethyl cellulose, make the more high resilience of its film body.Therefore add ethyl cellulose to contribute to increase the elasticity of film body.
2) from above-mentioned prescription 1-3, can find out, ethyl cellulose is more applicable to polyvinyl butyral.
2, viscosity adjustment research
Liquid adhesive bandage is using surface tension and the too high sprayer unit that causes using common press type of viscosity due to material in injection apparatus.Impact by the Liquid Properties On Drop Mean Diameter In Effervescent Atomization Spray on classical can be recognized, in high surface tension and full-bodied situation, expect the average droplet size of very little SMD() must increase impelling pressure and reduce nozzle diameter, this will increase substantially production cost, is unfavorable for the exploitation of product.Therefore in order to be designed to the sprayer unit of common press type, need to reduce viscosity and the surface tension to pleurodiaphragmatic in terspace liquid.
Selecting in viscosity adjustment, tentatively selecting polyoxyethylene hydrogenated Oleum Ricini, liquid paraffin, low viscosity dimethicone, ethyl oleate, triglyceride as plasticising adjusting adhesive.
The results are shown in Table 3, percentage ratio is mass percent (PVB is polyvinyl butyral, and EC is ethyl cellulose) described in following table
Ethyl oleate is more applicable to the adjusting of viscosity as can be seen from Table 3, and further preferred oil acetoacetic ester is as plasticising adjusting adhesive, and concentration is controlled at 0 ~ 8%, further optimizes concentration and is controlled at 3 ~ 6%.
3, anti-stick research
The requirement of liquid adhesive bandage is film forming in 1 minute, this will produce another unfavorable factor, after injection, understand residual stock solution in the above at spray valve, film forming causes spray valve to stop up at once, find that by studying us isobutyltrimethylmethane. can not only accelerate the volatilization of pleurodiaphragmatic in terspace liquid, and lubricated spray valve prevents from stopping up valve, concentration is controlled at 1 ~ 20%, further optimizes concentration and is controlled at 3 ~ 10%.And realize by the following method.Film forming stock solution in formula is packed in spray bottle, sprayed 3 times every 5 minutes, observe jet power and droplet spray pattern.Formula table, in table 4, the results are shown in Table 5.
Recipe is as follows:
1) preparation of ethyl cellulose: the ethyl cellulose of recipe quantity is fully swelling, for subsequent use in appropriate alcoholic solution;
2) prescription 1 preparation: by the polyvinyl butyral of recipe quantity, ethyl cellulose solution, ethyl oleate, isobutyltrimethylmethane. mix homogeneously, add the ethanol of surplus, fully dissolving and get final product;
3) contrast 1 preparation: by the polyvinyl butyral of recipe quantity, ethyl cellulose solution, ethyl oleate, mix homogeneously, add the ethanol of surplus, fully dissolving and get final product.
4, the pharmacological datum of wound healing ability
Generally speaking, scratch, in the case of the protection of traditional adhesive bandage, about 3 days and could form a scab, and within about 2 weeks, could heal completely.
The present invention has carried out significant improvement with respect to existing adhesive bandage technology, more understands the mode of accelerating wound, and making of designing in such a way it is more ventilative, fungi-proofing, antibacterial, bioadhesive is good, can moistening wound.
With the liquid adhesive bandage that contains 0.2% benzalkonium chloride of embodiment 1, carry out pharmacological research.
4.1 wound healing situations are observed
Abrasive situation as shown in Figure 1; Use the wound after 1 day to form a scab situation as shown in Figure 2; Use wound healing situation after 5 days as shown in Figure 3.
From accompanying drawing 1 ~ 3, we can find out, the healing rate of wound is obviously accelerated, and illustrates that this product has facilitation to the healing of wound.
From accompanying drawing 4 ~ 6, we can find out, this product has good hydrophobicity, and biocompatibility is non-stimulated to wound, without anaphylaxis, can well protect wound.
4.2 contrast the bactericidal effect of liquid adhesive bandage of the present invention, prior art liquid adhesive bandage, traditional adhesive plaster adhesive bandage and 0.2% Benza, the results are shown in Table 6
From table 6, can clearly find out, liquid adhesive bandage of the present invention has obvious bactericidal effect with respect to other adhesive bandages, and can obviously strengthen the sterilizing ability of benzalkonium chloride.
Claims (3)
1. one kind is used for the treatment of abrasive wound spray, it is characterized in that, formed by functional component and blank film forming stock solution, said functional component is selected from one or more in disinfectant for external use, topical antibiotic, local anesthetic and skin contraction composition, and said blank film forming stock solution comprises polyvinyl butyral, coalescents, plasticising adjusting adhesive, surfactant, helps volatilization antiplastering aid, porogen, aromatic and solvent;
Each composition shared mass percent in wound spray is as follows:
Wherein, said coalescents is ethyl cellulose; Said plasticising adjusting adhesive is selected from ethyl oleate, triethyl citrate, diethyl phthalate, dimethyl phthalate or dibutyl phthalate; Said surfactant is sodium lauryl sulphate; Said help volatilization antiplastering aid be isobutyltrimethylmethane.; Said porogen is polyvinylpyrrolidone-vinyl acetate co-polymer or polyvinylpyrrolidone; Said aromatic is rose essence, Flos Jasmini Sambac Oleum sesami, wintergreen oil, Oleum menthae or Eucalyptus oil; Said solvent is one or several in ethanol, ethyl acetate, acetone, propylene glycol.
2. be according to claim 1ly used for the treatment of abrasive wound spray, it is characterized in that, said disinfectant for external use is selected from polymer, acrylic disulfide or the acrylic trithioether of benzalkonium chloride, benzalkonium bromide, iodine, iodine; Said topical antibiotic is selected from mupirocin, erythromycin or griseofulvin; Said local anesthetic is lignocaine, procaine, tetracaine, bupivacaine or ropivacaine; Said skin contraction composition is selected from tannic acid, silver nitrate or zinc sulfate.
3. the preparation method that is used for the treatment of abrasive wound spray as claimed in claim 1 or 2, is characterized in that, comprises the steps:
1) functional component is pre-prepared: take functional component, aromatic, porogen, the surfactant mix homogeneously of recipe quantity, add appropriate solvent, and for subsequent use after fully disperseing in high speed homogenization dispersion machine;
2) blank film forming stock solution preparation: take recipe quantity polyvinyl butyral, plasticising adjusting adhesive, coalescents, help volatilization antiplastering aid mix homogeneously, add the solvent of surplus, mix homogeneously, dissolves it completely;
3) by reserve liquid and the step 2 of step 1)) the abundant mix homogeneously of blank film forming stock solution, and pour in sprayer unit and get final product.
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| CN104971377A (en) * | 2015-06-23 | 2015-10-14 | 潘秀娟 | Liquid wound glue and preparation method |
| CN105363066B (en) * | 2015-11-30 | 2018-07-06 | 江苏华能药业有限公司 | A kind of liquid adhesive bandage |
| CN106563129B (en) * | 2016-10-31 | 2019-10-22 | 江苏长泰药业有限公司 | It is a kind of for wound protection composition and its formation application |
| KR102208595B1 (en) * | 2017-04-19 | 2021-01-28 | 카오카부시키가이샤 | Film production method |
| CN107616971A (en) * | 2017-08-16 | 2018-01-23 | 稳健医疗用品股份有限公司 | A kind of liquid spray bandage, wound spray liquid and preparation method thereof |
| WO2022133629A1 (en) * | 2020-12-21 | 2022-06-30 | 江苏奇力康皮肤药业有限公司 | Spray type liquid bandage and preparation method therefor |
| WO2022133626A1 (en) * | 2020-12-21 | 2022-06-30 | 江苏奇力康皮肤药业有限公司 | Rapid film-forming liquid band-aid and preparation method therefor |
| CN113181420B (en) * | 2021-05-07 | 2022-03-11 | 多能干细胞再生医学科技（广州）有限公司 | Liquid wound dressing for quickly repairing skin superficial injury and preparation method thereof |
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