CN109513035A - A kind of multi-functional bearing hydrocolloid dressing and preparation method thereof - Google Patents
A kind of multi-functional bearing hydrocolloid dressing and preparation method thereof Download PDFInfo
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- CN109513035A CN109513035A CN201811523114.9A CN201811523114A CN109513035A CN 109513035 A CN109513035 A CN 109513035A CN 201811523114 A CN201811523114 A CN 201811523114A CN 109513035 A CN109513035 A CN 109513035A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/30—Rubbers or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Abstract
The invention belongs to medical dressing technical fields, and in particular to a kind of multi-functional bearing hydrocolloid dressing and preparation method thereof.Multi-functional bearing hydrocolloid dressing provided by the invention, including fixing layer, peeling layer and the hydrocolloid layer between the fixing layer and the peeling layer, the hydrocolloid layer includes following components and its mass fraction: 25-35 parts of composite polymer material, 20-25 parts of natural rubber, 0.2-0.4 parts of antioxidant, 5-8 parts of multifunction additive.Multi-functional bearing hydrocolloid dressing provided by the invention is non-stimulated to human skin, and use is safe.Multi-functional bearing hydrocolloid dressing provided by the invention is vdiverse in function, has excellent performance, and water imbibition is strong, has significant imbibition ability, has stronger antibacterial action, accelerates wound healing.In addition, the stability of multi-functional bearing hydrocolloid dressing provided by the invention is high, effect stability.
Description
Technical field
The invention belongs to medical dressing technical fields, and in particular to a kind of multi-functional bearing hydrocolloid dressing and preparation method thereof.
Background technique
Human skin can maintain human internal environment to stablize, and prevent it by bigger damage and prevent microorganism invasion.When
Skin damage, under conditions of normal function is destroyed, medical dressing can protect human body, avoid injuring.It is extensive in skin
Before multiple, the good wound-surface cover of a performance can temporarily play the role of barrier function, and providing one for wound healing has
The microenvironment of benefit.In the healing of wound, dressing can be used to flap coverage.
The representative of traditional dressing is gauze.Gauze is inertia dressing, is process by cotton, linen and lint.This
Although kind of dressing have many advantages, such as to protect the surface of a wound, absorbability it is good, it is cheap, make simple, reusable, disadvantage is also very
It is prominent, such as to the healing of the surface of a wound without being obviously promoted effect；It can cause pain when dressing；When dressing is saturated, pathogen is easily logical
It crosses；Dressing heavy workload；When dressing, easy damaged cambium etc..The deficiency of traditional dressing promotes the exploitation of new pattern compress.
Oneself is gradually developed can not only to cover skin surface modern medical wound dressing, but also can promote wound group
The functionalization again knitted.The primary and foremost purpose of these dressing is to create moist environment in wound surface, promotes tissue repair.It is modern medical
Dressing is usually to be made by synthesizing class or natural class macromolecule, and this kind of dressing can be divided into film, foam, alginic acid according to material
Salt, hydrogel and bearing hydrocolloid dressing.Hydrocolloid functional dressing is that one kind has many advantages, such as adsorptivity, waterproof, prevents adhesion, moisturizing
Novel application.
Chinese patent application CN 105797201A discloses a kind of compound hydrocolloid, preparation method and bearing hydrocolloid dressing,
By weight, the composition of raw materials of compound hydrocolloid includes: 10~30 parts of epithelical cell growth factor；10~30 parts of microcapsules；
20~40 parts of sodium carboxymethylcellulose；0.5~5 part of pectin；40~100 parts of adhesive.Although EGF hydrocolloid described in the invention
Dressing is applied widely, is applicable to the nursing of a variety of skin wounds, and still, the microcapsules are that will be slow at 30 DEG C or more
The microcapsules of broken wall will affect the stability of the bearing hydrocolloid dressing, and then influence using effect when temperature is higher.
Currently, hydrocolloid functional dressings type available on the market is more, still, big multi-functional more single, performance is paid no attention to
Think.
Summary of the invention
In view of the deficiencies of the prior art, the purpose of the present invention is to provide a kind of multi-functional bearing hydrocolloid dressing and its preparation sides
Method.Multi-functional bearing hydrocolloid dressing provided by the invention is non-stimulated to human skin, and use is safe.Multifunctional water provided by the invention
Colloid dressing is vdiverse in function, has excellent performance, and water imbibition is strong, has significant imbibition ability, has stronger antibacterial action, accelerates
Wound healing.In addition, the stability of multi-functional bearing hydrocolloid dressing provided by the invention is high, effect stability.
The technical scheme is that
A kind of multifunctional water colloid, the multifunctional water colloid includes following components and its mass fraction:
25-35 parts of composite polymer material, 20-25 parts of natural rubber, 0.2-0.4 parts of antioxidant, multifunction additive
5-8 parts.
Further, the multifunctional water colloid includes following components and its mass fraction:
30 parts of composite polymer material, 23 parts of natural rubber, 0.3 part of antioxidant, 7 parts of multifunction additive.
Further, the multifunctional water colloid further includes 8-12 parts of atoleine.
Further, the multifunctional water colloid further includes 10 parts of atoleine.
Further, the composite polymer material is by polyvinyl alcohol, croscarmellose sodium and carboxymethyl cellulose
Plain sodium 12-15:5-7:1-3 in mass ratio composition.
Further, the composite polymer material is fine by polyvinyl alcohol, croscarmellose sodium and carboxymethyl
Tie up element sodium 13:6:2 in mass ratio composition.
Further, the average molecular weight of the polyvinyl alcohol is 16000.
Further, the antioxidant is made of dendrobium nobile polyphenol and chitosan oligosaccharide 1-3:6-8 in mass ratio.
Further, the antioxidant is made of dendrobium nobile polyphenol and chitosan oligosaccharide 2:7 in mass ratio.
Further, the multifunction additive is made of Sodium Caseinate and fibroin albumen 2-4:8-10 in mass ratio.
Further, the multifunction additive is made of Sodium Caseinate and fibroin albumen 3:10 in mass ratio.
Dendrobium nobile is the stem of orchid family Dendrobium Sw Dendrobidium huoshanness.Dendrobium nobile polyphenol the preparation method comprises the following steps: take dendrobium nobile, be ground into thin
Powder crosses 50 meshes, adds water, and twice, the additive amount of water is 8 times of dendrobium nobile quality to ultrasonic extraction, and ultrasonic power is 120W, surpasses
The sound time is 50min, merges extracting solution twice, is concentrated under reduced pressure into the medicinal extract that relative density is 1.15, dry, pulverize to get.
Another object of the present invention is to provide the multifunctional water colloids to prepare the application in bearing hydrocolloid dressing.
A kind of multi-functional bearing hydrocolloid dressing, including fixing layer, peeling layer and positioned at the fixing layer and the stripping
Hydrocolloid layer between absciss layer, the hydrocolloid layer are above-mentioned multifunctional water colloid.
In addition, steps are as follows the present invention also provides the preparation method of multi-functional bearing hydrocolloid dressing:
Natural rubber, antioxidant, multifunction additive are added in mixer S1, take out in 90-120 DEG C of following side of mediating
Composite polymer material is added in vacuum, mixes 10-15min, obtains hydrocolloid；
Hydrocolloid injection molding obtained by step S1 on the fixing layer, is then carried out aging by S2 at 30-50 DEG C
Processing 40-60h forms the hydrocolloid layer, and the peeling layer is covered on the hydrocolloid layer, is then pressed and molded, i.e.,
?.
Multi-functional bearing hydrocolloid dressing provided by the invention include fixing layer, peeling layer and positioned at the fixing layer and
Hydrocolloid layer between the peeling layer, the hydrocolloid layer include composite polymer material, natural rubber, antioxidant,
Multifunction additive, atoleine.In the present invention, by polyvinyl alcohol, croscarmellose sodium and sodium carboxymethylcellulose
Composite polymer material by certain mass than composition can control and absorb wound exudate, and imbibition ability is significant, can promote
Into wound healing.In the present invention, it can be significantly increased by certain mass than the antioxidant formed by dendrobium nobile polyphenol and chitosan oligosaccharide
The anti-microbial property of dressing, can prevent bacterium intrusion and it is antibacterial, regeneration can be promoted but also prevent bacterium infection.The present invention
In, the stability of dressing can be enhanced by the multifunction additive that Sodium Caseinate and fibroin albumen are formed by certain mass, enhanced
The stability of using effect.
Compared with prior art, present invention has the advantage that
(1) multifunctional water colloid dressing provided by the invention has good biocompatibility, non-stimulated to human skin,
Using safe.
(2) multi-functional bearing hydrocolloid dressing provided by the invention can control and absorb wound exudate, and imbibition ability is significant,
It can promote wound healing.
(3) multi-functional bearing hydrocolloid dressing provided by the invention can prevent bacterium intrusion and it is antibacterial, tissue can be promoted again
It is raw to prevent bacterium infection again.
(4) multi-functional bearing hydrocolloid dressing stability provided by the invention is high, effect stability.
(5) multi-functional bearing hydrocolloid dressing good permeability provided by the invention, soft and toughness is preferable, when more change dressings
It is not damaged.
Specific embodiment
The following describes the present invention further through the description of specific embodiments, but it is to limit of the invention that this, which is not,
System, those skilled in the art's basic thought according to the present invention can make various modifications or improvements, but without departing from this
The basic thought of invention, is all within the scope of the present invention.
In the present invention, sodium carboxymethylcellulose is purchased from Zhejiang Zhong Tuan Bioisystech Co., Ltd, article No.: 0018355；It hands over
Connection sodium carboxymethylcellulose is purchased from Foshan Sheng Yi Biotechnology Co., Ltd, article No.: 20180505；Natural rubber is purchased from
Hai Sanlian Industrial Co., Ltd., model: SCRWF；Sodium Caseinate is purchased from the beneficial Fine Chemical Co., Ltd in Guangzhou thousand, article No.:
180613；Chitosan oligosaccharide is purchased from Shaanxi Sen Fu natural product Co., Ltd, article No.: KGT180801；Fibroin albumen is purchased from Xi'an
Green such as spring Biotechnology Co., Ltd, model: 6845.
Embodiment 1, a kind of multi-functional bearing hydrocolloid dressing
The multi-functional bearing hydrocolloid dressing, including fixing layer, peeling layer and positioned at the fixing layer and the stripping
Hydrocolloid layer between absciss layer, the fixing layer are polyurethane film, and the peeling layer is polytetrafluoroethylene film；The hydrocolloid
Layer is multifunctional water colloid, and the multifunctional water colloid includes following components and its mass fraction:
25 parts of composite polymer material, 20 parts of natural rubber, 0.2 part of antioxidant, 5 parts of multifunction additive；It is described multiple
Close polyvinyl alcohol, croscarmellose sodium and sodium carboxymethylcellulose that high molecular material is 16000 by average molecular weight
The composition of 12:7:3 in mass ratio；The antioxidant is made of dendrobium nobile polyphenol and chitosan oligosaccharide 1:8 in mass ratio；It is described multi-functional to add
Agent is added to be made of Sodium Caseinate and fibroin albumen 2:10 in mass ratio.
Dendrobium nobile polyphenol the preparation method comprises the following steps: take dendrobium nobile, be ground into fine powder, cross 50 meshes, add water, ultrasonic extraction twice, water
Additive amount be 8 times of dendrobium nobile quality, ultrasonic power is 120W, and ultrasonic time is 50min, merge extracting solution twice,
Be concentrated under reduced pressure into relative density be 1.15 medicinal extract, dry, pulverize to get.
The preparation method of multi-functional bearing hydrocolloid dressing:
Natural rubber, antioxidant, multifunction additive are added in mixer S1, take out very in 90 DEG C of following sides of mediating
Composite polymer material is added in sky, mixes 10min, obtains hydrocolloid；
Hydrocolloid injection molding obtained by step S1 on the fixing layer, is then carried out aging process by S2 at 30 DEG C
40h forms the hydrocolloid layer, and the peeling layer is covered on the hydrocolloid layer, be then pressed and molded to get.
Embodiment 2, a kind of multi-functional bearing hydrocolloid dressing
The multi-functional bearing hydrocolloid dressing, including fixing layer, peeling layer and positioned at the fixing layer and the stripping
Hydrocolloid layer between absciss layer, the fixing layer are polyurethane film, and the peeling layer is polytetrafluoroethylene film；The hydrocolloid
Layer is multifunctional water colloid, and the multifunctional water colloid includes following components and its mass fraction:
35 parts of composite polymer material, 25 parts of natural rubber, 0.4 part of antioxidant, 8 parts of multifunction additive；It is described multiple
Close polyvinyl alcohol, croscarmellose sodium and sodium carboxymethylcellulose that high molecular material is 16000 by average molecular weight
The composition of 15:5:1 in mass ratio；The antioxidant is made of dendrobium nobile polyphenol and chitosan oligosaccharide 3:6 in mass ratio；It is described multi-functional to add
Agent is added to be made of Sodium Caseinate and fibroin albumen 4:8 in mass ratio.
The preparation method of dendrobium nobile polyphenol is similar to Example 1.
The preparation method of multi-functional bearing hydrocolloid dressing:
Natural rubber, antioxidant, multifunction additive are added in mixer S1, take out very in 120 DEG C of following sides of mediating
Composite polymer material is added in sky, mixes 15min, obtains hydrocolloid；
Hydrocolloid injection molding obtained by step S1 on the fixing layer, is then carried out aging process by S2 at 50 DEG C
60h forms the hydrocolloid layer, and the peeling layer is covered on the hydrocolloid layer, be then pressed and molded to get.
Embodiment 3, a kind of multi-functional bearing hydrocolloid dressing
The multi-functional bearing hydrocolloid dressing, including fixing layer, peeling layer and positioned at the fixing layer and the stripping
Hydrocolloid layer between absciss layer, the fixing layer are polyurethane film, and the peeling layer is polytetrafluoroethylene film；The hydrocolloid
Layer is multifunctional water colloid, and the multifunctional water colloid includes following components and its mass fraction:
25 parts of composite polymer material, 20 parts of natural rubber, 0.2 part of antioxidant, 5 parts of multifunction additive, liquid stone
8 parts of wax；Polyvinyl alcohol, croscarmellose sodium and the carboxylic that the composite polymer material is 16000 by average molecular weight
Sodium carboxymethylcellulose pyce 12:7:3 in mass ratio composition；The antioxidant is made of dendrobium nobile polyphenol and chitosan oligosaccharide 1:8 in mass ratio；
The multifunction additive is made of Sodium Caseinate and fibroin albumen 2:10 in mass ratio.
The preparation method of dendrobium nobile polyphenol is similar to Example 1.
The preparation method of multi-functional bearing hydrocolloid dressing:
Natural rubber, atoleine, antioxidant, multifunction additive are added in mixer S1, pinch below in 90 DEG C
It closes side to vacuumize, composite polymer material is added, mix 10min, obtain hydrocolloid；
Hydrocolloid injection molding obtained by step S1 on the fixing layer, is then carried out aging process by S2 at 30 DEG C
40h forms the hydrocolloid layer, and the peeling layer is covered on the hydrocolloid layer, be then pressed and molded to get.
Embodiment 4, a kind of multi-functional bearing hydrocolloid dressing
The multi-functional bearing hydrocolloid dressing, including fixing layer, peeling layer and positioned at the fixing layer and the stripping
Hydrocolloid layer between absciss layer, the fixing layer are polyurethane film, and the peeling layer is polytetrafluoroethylene film；The hydrocolloid
Layer is multifunctional water colloid, and the multifunctional water colloid includes following components and its mass fraction:
35 parts of composite polymer material, 25 parts of natural rubber, 0.4 part of antioxidant, 8 parts of multifunction additive, liquid stone
12 parts of wax；Polyvinyl alcohol, croscarmellose sodium and the carboxylic that the composite polymer material is 16000 by average molecular weight
Sodium carboxymethylcellulose pyce 15:5:1 in mass ratio composition；The antioxidant is made of dendrobium nobile polyphenol and chitosan oligosaccharide 3:6 in mass ratio；
The multifunction additive is made of Sodium Caseinate and fibroin albumen 4:8 in mass ratio.
The preparation method of dendrobium nobile polyphenol is similar to Example 1.
The preparation method of multi-functional bearing hydrocolloid dressing:
Natural rubber, atoleine, antioxidant, multifunction additive are added in mixer S1, pinch below in 120 DEG C
It closes side to vacuumize, composite polymer material is added, mix 15min, obtain hydrocolloid；
Hydrocolloid injection molding obtained by step S1 on the fixing layer, is then carried out aging process by S2 at 50 DEG C
60h forms the hydrocolloid layer, and the peeling layer is covered on the hydrocolloid layer, be then pressed and molded to get.
Embodiment 5, a kind of multi-functional bearing hydrocolloid dressing
The multi-functional bearing hydrocolloid dressing, including fixing layer, peeling layer and positioned at the fixing layer and the stripping
Hydrocolloid layer between absciss layer, the fixing layer are polyurethane film, and the peeling layer is polytetrafluoroethylene film；The hydrocolloid
Layer is multifunctional water colloid, and the multifunctional water colloid includes following components and its mass fraction:
30 parts of composite polymer material, 23 parts of natural rubber, 0.3 part of antioxidant, 7 parts of multifunction additive, liquid stone
10 parts of wax；Polyvinyl alcohol, croscarmellose sodium and the carboxylic that the composite polymer material is 16000 by average molecular weight
Sodium carboxymethylcellulose pyce 13:6:2 in mass ratio composition；The antioxidant is made of dendrobium nobile polyphenol and chitosan oligosaccharide 2:7 in mass ratio；
The multifunction additive is made of Sodium Caseinate and fibroin albumen 3:10 in mass ratio.
The preparation method of dendrobium nobile polyphenol is similar to Example 1.
The preparation method of multi-functional bearing hydrocolloid dressing:
Natural rubber, atoleine, antioxidant, multifunction additive are added in mixer S1, pinch below in 105 DEG C
It closes side to vacuumize, composite polymer material is added, mix 13min, obtain hydrocolloid；
Hydrocolloid injection molding obtained by step S1 on the fixing layer, is then carried out aging process by S2 at 40 DEG C
45h forms the hydrocolloid layer, and the peeling layer is covered on the hydrocolloid layer, be then pressed and molded to get.
Comparative example 1, a kind of multi-functional bearing hydrocolloid dressing
The multi-functional bearing hydrocolloid dressing, including fixing layer, peeling layer and positioned at the fixing layer and the stripping
Hydrocolloid layer between absciss layer, the fixing layer are polyurethane film, and the peeling layer is polytetrafluoroethylene film；The hydrocolloid
Layer is multifunctional water colloid, and the multifunctional water colloid includes following components and its mass fraction:
30 parts of composite polymer material, 23 parts of natural rubber, 0.3 part of antioxidant, 7 parts of multifunction additive, liquid stone
10 parts of wax；Polyvinyl alcohol, croscarmellose sodium and the carboxylic that the composite polymer material is 16000 by average molecular weight
Sodium carboxymethylcellulose pyce 1:1:1 in mass ratio composition；The antioxidant is made of dendrobium nobile polyphenol and chitosan oligosaccharide 2:7 in mass ratio；
The multifunction additive is made of Sodium Caseinate and fibroin albumen 3:10 in mass ratio.
The preparation method of dendrobium nobile polyphenol is similar to Example 1.
The preparation method of multi-functional bearing hydrocolloid dressing is similar to Example 5.
Difference with embodiment 5 is, polyvinyl alcohol that the composite polymer material is 16000 by average molecular weight,
Croscarmellose sodium and sodium carboxymethylcellulose 1:1:1 in mass ratio composition.
Comparative example 2, a kind of multi-functional bearing hydrocolloid dressing
The multi-functional bearing hydrocolloid dressing, including fixing layer, peeling layer and positioned at the fixing layer and the stripping
Hydrocolloid layer between absciss layer, the fixing layer are polyurethane film, and the peeling layer is polytetrafluoroethylene film；The hydrocolloid
Layer is multifunctional water colloid, and the multifunctional water colloid includes following components and its mass fraction:
30 parts of composite polymer material, 23 parts of natural rubber, 0.3 part of antioxidant, 7 parts of multifunction additive, liquid stone
10 parts of wax；Polyvinyl alcohol, croscarmellose sodium and the carboxylic that the composite polymer material is 16000 by average molecular weight
Methyl chitosan 13:6:2 in mass ratio composition；The antioxidant is made of dendrobium nobile polyphenol and chitosan oligosaccharide 2:7 in mass ratio；Institute
Multifunction additive is stated to be made of Sodium Caseinate and fibroin albumen 3:10 in mass ratio.
The preparation method of dendrobium nobile polyphenol is similar to Example 1.
The preparation method of multi-functional bearing hydrocolloid dressing is similar to Example 5.
Difference with embodiment 5 is, polyvinyl alcohol that the composite polymer material is 16000 by average molecular weight,
Croscarmellose sodium and carboxymethyl chitosan 13:6:2 in mass ratio composition.
Comparative example 3, a kind of multi-functional bearing hydrocolloid dressing
The multi-functional bearing hydrocolloid dressing, including fixing layer, peeling layer and positioned at the fixing layer and the stripping
Hydrocolloid layer between absciss layer, the fixing layer are polyurethane film, and the peeling layer is polytetrafluoroethylene film；The hydrocolloid
Layer is multifunctional water colloid, and the multifunctional water colloid includes following components and its mass fraction:
30 parts of composite polymer material, 23 parts of natural rubber, 0.3 part of antioxidant, 7 parts of multifunction additive, liquid stone
10 parts of wax；Polyvinyl alcohol, croscarmellose sodium and the carboxylic that the composite polymer material is 20000 by average molecular weight
Sodium carboxymethylcellulose pyce 13:6:2 in mass ratio composition；The antioxidant is made of dendrobium nobile polyphenol and chitosan oligosaccharide 2:7 in mass ratio；
The multifunction additive is made of Sodium Caseinate and fibroin albumen 3:10 in mass ratio.
The preparation method of dendrobium nobile polyphenol is similar to Example 1.
The preparation method of multi-functional bearing hydrocolloid dressing is similar to Example 3.
Difference with embodiment 3 is, polyvinyl alcohol that the composite polymer material is 20000 by average molecular weight,
Croscarmellose sodium and sodium carboxymethylcellulose 13:6:2 in mass ratio composition.
Comparative example 4, a kind of multi-functional bearing hydrocolloid dressing
The multi-functional bearing hydrocolloid dressing, including fixing layer, peeling layer and positioned at the fixing layer and the stripping
Hydrocolloid layer between absciss layer, the fixing layer are polyurethane film, and the peeling layer is polytetrafluoroethylene film；The hydrocolloid
Layer is multifunctional water colloid, and the multifunctional water colloid includes following components and its mass fraction:
30 parts of composite polymer material, 23 parts of natural rubber, 0.3 part of antioxidant, 7 parts of multifunction additive, liquid stone
10 parts of wax；The polyvinyl alcohol and croscarmellose sodium that the composite polymer material is 16000 by average molecular weight are pressed
Mass ratio 13:6 composition；The antioxidant is made of dendrobium nobile polyphenol and chitosan oligosaccharide 2:7 in mass ratio；The multifunction additive
It is made of Sodium Caseinate and fibroin albumen 3:10 in mass ratio.
The preparation method of dendrobium nobile polyphenol is similar to Example 1.
The preparation method of multi-functional bearing hydrocolloid dressing is similar to Example 5.
Difference with embodiment 5 is, the composite polymer material by average molecular weight be 16000 polyvinyl alcohol and
Croscarmellose sodium 13:6 in mass ratio composition.
Comparative example 5, a kind of multi-functional bearing hydrocolloid dressing
The multi-functional bearing hydrocolloid dressing, including fixing layer, peeling layer and positioned at the fixing layer and the stripping
Hydrocolloid layer between absciss layer, the fixing layer are polyurethane film, and the peeling layer is polytetrafluoroethylene film；The hydrocolloid
Layer is multifunctional water colloid, and the multifunctional water colloid includes following components and its mass fraction:
30 parts of composite polymer material, 23 parts of natural rubber, 0.3 part of antioxidant, 7 parts of multifunction additive, liquid stone
10 parts of wax；Polyvinyl alcohol, croscarmellose sodium and the carboxylic that the composite polymer material is 16000 by average molecular weight
Sodium carboxymethylcellulose pyce 13:6:2 in mass ratio composition；The antioxidant is made of dendrobium nobile polyphenol and chitosan oligosaccharide 1:1 in mass ratio；
The multifunction additive is made of Sodium Caseinate and fibroin albumen 3:10 in mass ratio.
The preparation method of dendrobium nobile polyphenol is similar to Example 1.
The preparation method of multi-functional bearing hydrocolloid dressing is similar to Example 5.
Difference with embodiment 5 is that the antioxidant is made of dendrobium nobile polyphenol and chitosan oligosaccharide 1:1 in mass ratio.
Comparative example 6, a kind of multi-functional bearing hydrocolloid dressing
The multi-functional bearing hydrocolloid dressing, including fixing layer, peeling layer and positioned at the fixing layer and the stripping
Hydrocolloid layer between absciss layer, the fixing layer are polyurethane film, and the peeling layer is polytetrafluoroethylene film；The hydrocolloid
Layer is multifunctional water colloid, and the multifunctional water colloid includes following components and its mass fraction:
30 parts of composite polymer material, 23 parts of natural rubber, 0.3 part of antioxidant, 7 parts of multifunction additive, liquid stone
10 parts of wax；Polyvinyl alcohol, croscarmellose sodium and the carboxylic that the composite polymer material is 16000 by average molecular weight
Sodium carboxymethylcellulose pyce 13:6:2 in mass ratio composition；The antioxidant is chitosan oligosaccharide；The multifunction additive is by caseinic acid
Sodium and fibroin albumen 3:10 in mass ratio composition.
The preparation method of multi-functional bearing hydrocolloid dressing is similar to Example 5.
Difference with embodiment 5 is that the antioxidant is chitosan oligosaccharide.
Comparative example 7, a kind of multi-functional bearing hydrocolloid dressing
The multi-functional bearing hydrocolloid dressing, including fixing layer, peeling layer and positioned at the fixing layer and the stripping
Hydrocolloid layer between absciss layer, the fixing layer are polyurethane film, and the peeling layer is polytetrafluoroethylene film；The hydrocolloid
Layer is multifunctional water colloid, and the multifunctional water colloid includes following components and its mass fraction:
30 parts of composite polymer material, 23 parts of natural rubber, 0.3 part of antioxidant, 7 parts of multifunction additive, liquid stone
10 parts of wax；Polyvinyl alcohol, croscarmellose sodium and the carboxylic that the composite polymer material is 16000 by average molecular weight
Sodium carboxymethylcellulose pyce 13:6:2 in mass ratio composition；The antioxidant is made of dendrobium nobile polyphenol and chitosan oligosaccharide 2:7 in mass ratio；
The multifunction additive is made of Sodium Caseinate and fibroin albumen 1:1 in mass ratio.
The preparation method of dendrobium nobile polyphenol is similar to Example 1.
The preparation method of multi-functional bearing hydrocolloid dressing is similar to Example 5.
Difference with embodiment 5 is that the multifunction additive is by Sodium Caseinate and fibroin albumen 1:1 group in mass ratio
At.
Comparative example 8, a kind of multi-functional bearing hydrocolloid dressing
The multi-functional bearing hydrocolloid dressing, including fixing layer, peeling layer and positioned at the fixing layer and the stripping
Hydrocolloid layer between absciss layer, the fixing layer are polyurethane film, and the peeling layer is polytetrafluoroethylene film；The hydrocolloid
Layer is multifunctional water colloid, and the multifunctional water colloid includes following components and its mass fraction:
30 parts of composite polymer material, 23 parts of natural rubber, 0.3 part of antioxidant, 7 parts of multifunction additive, liquid stone
10 parts of wax；Polyvinyl alcohol, croscarmellose sodium and the carboxylic that the composite polymer material is 16000 by average molecular weight
Sodium carboxymethylcellulose pyce 13:6:2 in mass ratio composition；The antioxidant is made of dendrobium nobile polyphenol and chitosan oligosaccharide 2:7 in mass ratio；
The multifunction additive is fibroin albumen.
The preparation method of dendrobium nobile polyphenol is similar to Example 1.
The preparation method of multi-functional bearing hydrocolloid dressing is similar to Example 5.
Difference with embodiment 5 is that the multifunction additive is fibroin albumen.
Test example one, performance study
1, test material: multifunctional water colloid prepared by embodiment 1, embodiment 2, embodiment 3, embodiment 4, embodiment 5
Dressing.
2, test method:
Cell toxicity test (GB/T14233.2- is carried out respectively to multi-functional bearing hydrocolloid dressing prepared by embodiment 1-5
2005 chapter 8), sensitization test (STT) (GB/T16886.10-2005 chapter 7), intradermal reaction test (GB/T16886.10-
2005), systemic acute toxi-city test (GB/T 16886.11-2011 chapter 5).
3, test result: testing result is as shown in table 1.
Table 1: performance test results
| Experimental project | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Cytotoxicity | Nothing | Nothing | Nothing | Nothing | Nothing |
| Sensitization | Nothing | Nothing | Nothing | Nothing | Nothing |
| Intradermal reaction | Nothing | Nothing | Nothing | Nothing | Nothing |
| Systemic acute toxi-city | Nothing | Nothing | Nothing | Nothing | Nothing |
As can be seen from Table 1, multi-functional bearing hydrocolloid dressing no cytotoxicity produced by the present invention, without sensitization, without intradermal
It reacts, without systemic acute toxi-city, this illustrates that products obtained therefrom of the present invention has good biological safety and biocompatibility.
Test example two, stability experiment
1, test material: multifunctional water colloid prepared by embodiment 3, embodiment 4, embodiment 5, comparative example 7, comparative example 8
Dressing.
2, test method:
2.1, heat resistant test
10 multi-functional bearing hydrocolloid dressings are taken, backing is removed, respectively at keeping the temperature 2h in 40 DEG C of baking ovens, after letting cool, observation is applied
Expect that whether there is or not permeability phenomenon, there is tarnish on surface, whether there is or not stickiness with finger touching examination.
2.2, low temperature resistant test
It takes 10 multi-functional bearing hydrocolloid dressings, removes backing, respectively at being stored for 24 hours in -15 DEG C of low temperature refrigerators, after taking-up,
Observing dressing, whether there is or not obvious laminations.
3, test result: testing result is as shown in table 2.
Table 2: stability experiment testing result
As can be seen from Table 2, multi-functional bearing hydrocolloid dressing made from 3-5 of the embodiment of the present invention keeps the temperature 2h in 40 DEG C of baking ovens
After letting cool, no permeability phenomenon is glossy, still has stickiness with finger touching examination, shows multi-functional bearing hydrocolloid dressing produced by the present invention
Heat resistance is good.After multi-functional bearing hydrocolloid dressing made from 3-5 of the embodiment of the present invention is stored for 24 hours in -15 DEG C of low temperature refrigerators, not
See lamination, shows that multi-functional bearing hydrocolloid dressing cold resistance produced by the present invention is good.And more function of comparative example 7, comparative example 8
Can bearing hydrocolloid dressing keep the temperature in 40 DEG C of baking ovens after 2h lets cool, have permeability phenomenon, it is glossy, with finger touching examination without stickiness, compare
There is slight lamination after storing for 24 hours in -15 DEG C of low temperature refrigerators in the multi-functional bearing hydrocolloid dressing of example 7, comparative example 8
There is obvious lamination after storing for 24 hours in -15 DEG C of low temperature refrigerators in multi-functional bearing hydrocolloid dressing, illustrates comparative example 7, right
Heat resistance, the cold resistance of the multi-functional bearing hydrocolloid dressing of ratio 8 are poor.Compared with comparative example 7, comparative example 8, the present invention is multi-functional
Bearing hydrocolloid dressing has good heat resistance and cold resistance.
Test example three, bactericidal property
1, test material: embodiment 3, embodiment 4, multi-functional bearing hydrocolloid dressing made from embodiment 5, comparative example 5, comparison
Multi-functional bearing hydrocolloid dressing made from example 6.
2, test method:
Multi-functional bearing hydrocolloid dressing effect prepared by embodiment 3, embodiment 4, embodiment 5, comparative example 5, comparative example 6
The bactericidal property (GB15979-2002 appendix C) of 10min, 20min, 30min, 60min are detected.
3, test result: testing result is as shown in table 3.
Table 3: bactericidal property testing result
As shown in Table 3, multi-functional bearing hydrocolloid dressing provided by the invention, to staphylococcus aureus, big when acting on 10min
The bactericidal property of enterobacteria is more significant, and acts on 10min, 20min, 30min, 60min, to staphylococcus aureus, greatly
The bactericidal property of enterobacteria gradually increases, this illustrates that the bactericidal property of the multi-functional bearing hydrocolloid dressing of the present invention is quickly and lasting.
Wherein, the bactericidal property of embodiment 5 is best, is highly preferred embodiment of the present invention.And it is multi-functional made from comparative example 5, comparative example 6
Bearing hydrocolloid dressing is substantially less than more function made from the embodiment of the present invention 5 to the bactericidal property of staphylococcus aureus, Escherichia coli
Energy bearing hydrocolloid dressing, this illustrates that dendrobium nobile polyphenol and chitosan oligosaccharide compounding generate synergistic effect in the present invention, greatly strengthen its sterilization
Effect.
Test example four, liquid-absorbent
1, test material: embodiment 3, embodiment 4, multi-functional bearing hydrocolloid dressing made from embodiment 5, comparative example 1, comparison
Multi-functional bearing hydrocolloid dressing made from example 2, comparative example 3 and comparative example 4.
2, test method:
To multi-functional bearing hydrocolloid dressing made from embodiment 3, embodiment 4, embodiment 5, comparative example 1, comparative example 2, comparison
The liquid absorption amount (YY/T0471.1-2004) of multi-functional bearing hydrocolloid dressing made from example 3 and comparative example 4 is detected.
3, test result: testing result is as shown in table 4.
Table 4: liquid-absorbent testing result
As shown in Table 4, the liquid absorption amount of the multi-functional bearing hydrocolloid dressing of 3-5 of embodiment of the present invention offer is respectively
14.6g/100cm2、14.2g/100cm2、15.5g/100cm2, wherein the effect of embodiment 5 is best, is best reality of the invention
Apply example；The liquid absorption amount of multi-functional bearing hydrocolloid dressing provided by the invention is significantly larger than comparative example 1, comparative example 2, comparative example 3
With the liquid absorption amount (7.9g/100cm of multi-functional bearing hydrocolloid dressing made from comparative example 42、8.8g/100cm2、10.7g/
100cm2、4.2g/100cm2), this illustrates, polyvinyl alcohol, croscarmellose sodium and sodium carboxymethylcellulose in the present invention
Compounding generates synergistic effect, significantly enhances its ability for absorbing sepage.
Claims (10)
1. a kind of multifunctional water colloid, which is characterized in that the multifunctional water colloid includes following components and its mass fraction:
25-35 parts of composite polymer material, 20-25 parts of natural rubber, 0.2-0.4 parts of antioxidant, multifunction additive 5-8
Part.
2. multifunctional water colloid as described in claim 1, which is characterized in that the multifunctional water colloid include following components and
Its mass fraction:
30 parts of composite polymer material, 23 parts of natural rubber, 0.3 part of antioxidant, 7 parts of multifunction additive.
3. multifunctional water colloid as claimed in claim 1 or 2, which is characterized in that the multifunctional water colloid further includes liquid
8-12 parts of paraffin.
4. multifunctional water colloid as claimed in claim 1 or 2, which is characterized in that the composite polymer material is by polyethylene
Alcohol, croscarmellose sodium and sodium carboxymethylcellulose 12-15:5-7:1-3 in mass ratio composition.
5. multifunctional water colloid as claimed in claim 4, which is characterized in that the composite polymer material by polyvinyl alcohol,
Croscarmellose sodium and sodium carboxymethylcellulose 13:6:2 in mass ratio composition.
6. multifunctional water colloid as claimed in claim 1 or 2, which is characterized in that the antioxidant is by dendrobium nobile polyphenol and shell
Oligosaccharides 1-3:6-8 in mass ratio composition.
7. multifunctional water colloid as claimed in claim 1 or 2, which is characterized in that the multifunction additive is by Sodium Caseinate
It is formed with fibroin albumen 2-4:8-10 in mass ratio.
8. the multifunctional water colloid as described in claim 1-7 any one is preparing the application in bearing hydrocolloid dressing.
9. a kind of multi-functional bearing hydrocolloid dressing, including fixing layer, peeling layer and positioned at the fixing layer and the removing
Hydrocolloid layer between layer, which is characterized in that the hydrocolloid layer is multi-functional glue described in claim 1-7 any one
Body.
10. the preparation method of multi-functional bearing hydrocolloid dressing as claimed in claim 9, which comprises the following steps:
Natural rubber, antioxidant, multifunction additive are added in mixer S1, take out very in 90-120 DEG C of following side of mediating
Composite polymer material is added in sky, mixes 10-15min, obtains hydrocolloid；
Hydrocolloid injection molding obtained by step S1 on the fixing layer, is then carried out aging process by S2 at 30-50 DEG C
40-60h forms the hydrocolloid layer, and the peeling layer is covered on the hydrocolloid layer, be then pressed and molded to get.
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