CN106139239A - Full-service fluid dressing and preparation method thereof - Google Patents
Full-service fluid dressing and preparation method thereof Download PDFInfo
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- CN106139239A CN106139239A CN201610553348.2A CN201610553348A CN106139239A CN 106139239 A CN106139239 A CN 106139239A CN 201610553348 A CN201610553348 A CN 201610553348A CN 106139239 A CN106139239 A CN 106139239A
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- polyvinylpyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
Abstract
The present invention relates to field of medical accessory, it is specifically related to a kind of full-service fluid dressing and preparation method thereof, in parts by mass, component is polyvinyl butyral resin 28 parts, sodium alginate polyvinylpyrrolidone 0.5 0.8 parts, nano silver chitosan 0.2 0.6 parts, sodium carboxymethyl cellulose 0.1 0.4 parts, carrageenan 0.1 0.4 parts, Mentholum 0.1 0.4 parts and dehydrated alcohol 91 97 parts in full-service fluid dressing.Waterproof and breathable of the present invention, wound are visual, can prevent infection, be conducive to wound healing.
Description
Technical field
The present invention relates to field of medical accessory, particularly relate to a kind of full-service fluid dressing and preparation method thereof.
Background technology
When skin somewhere comes to harm, producing wound surface, need sterilization of stopping blooding timely, smearing ointment, simultaneously by medical
Germ contamination in adjuvant isolation environment.Existing medical dressing tack coat is typically coated with binding agent, typically at wound surface during use
After smearing ointment, then cover warp layer cloth, fix with dressing the most again.
On the one hand, owing to gauze is opaque, wound is not visible, it is impossible to check the healing state of wound surface in time, if do not covered
Lid gauze, can cause again extruding ointment, cause tack coat surrounding to lose cohesive force after being stained with ointment, it is impossible to firm, airtight is viscous
Skinning skin, affects wound healing.Second aspect, wound of adhering, can cause property mechanical injuries again during replacing.The third aspect,
Non-watertight, easily intake at wound wrapping, cause infection, easily affecting recovery effects even increases the weight of the state of an illness.Fourth aspect, impermeable
Gas, is unfavorable for wound healing.5th aspect, external environment microorganism easily by, the chance of cross infection is higher.6th side
Face, wraps up a gauze at wound, affect attractive in appearance.
Summary of the invention
For solving the problems referred to above, the present invention provides a kind of waterproof and breathable, wound is visual, can prevent infection, be conducive to wound
Full-service fluid dressing of healing and preparation method thereof.
The technical solution adopted in the present invention is: full-service fluid dressing, and in parts by mass, component is polyvinyl alcohol contracting fourth
Aldehyde 2-8 part, sodium alginate-polyvinylpyrrolidone 0.5-0.8 part, nanometer silver-chitosan 0.2-0.6 part, carboxymethyl cellulose
Sodium 0.1-0.4 part, carrageenan 0.1-0.4 part, Mentholum 0.1-0.4 part and dehydrated alcohol 91-97 part.
Being improved to further technique scheme, in described sodium alginate-polyvinylpyrrolidone sodium alginate with
The mass ratio of polyvinylpyrrolidone is 1:3.
Being improved to further technique scheme, the model of described polyvinyl butyral resin be viscosity 250CPS～
280CPS or 10s～15s；The specification of described polyvinylpyrrolidone is K20～K25.
Being improved to further technique scheme, in parts by mass, component is polyvinyl butyral resin 4 parts, Sargassum
Acid sodium-polyvinylpyrrolidone 0.5 part, nanometer silver-chitosan 0.4 part, sodium carboxymethyl cellulose 0.1 part, carrageenan 0.1 part,
Mentholum 0.1 part and dehydrated alcohol 94.8 parts.
Being improved to further technique scheme, in parts by mass, component is polyvinyl butyral resin 6 parts, Sargassum
Acid sodium-polyvinylpyrrolidone 0.6 part, nanometer silver-chitosan 0.5 part, sodium carboxymethyl cellulose 0.1 part, carrageenan 0.1 part,
Mentholum 0.1 part and dehydrated alcohol 92.6 parts.
Being improved to further technique scheme, in parts by mass, component is polyvinyl butyral resin 6 parts, Sargassum
Acid sodium-polyvinylpyrrolidone 0.6 part, nanometer silver-chitosan 0.5 part, sodium carboxymethyl cellulose 0.1 part, carrageenan 0.1 part,
Mentholum 0.1 part and dehydrated alcohol 92.6 parts.
The preparation method of full-service fluid dressing, comprises the following steps:
1. weigh the polyvinyl butyral resin of formula ratio, be dissolved in dehydrated alcohol, stir, prepare film forming solution；
2. weigh the sodium alginate-polyvinylpyrrolidone of formula ratio, be dissolved in dehydrated alcohol, stir, prepare pore
Solution；
3. weigh nanometer silver and the chitosan of formula ratio, be dissolved in dehydrated alcohol, stir, prepare germicidal solution；
4. take step 1. in film forming solution, step 2. in pore solution, step 3. in germicidal solution, stirring is all
Even, obtain mixed liquor；
5. take step 4. in mixed liquor, be added thereto to formula ratio sodium carboxymethyl cellulose, add formula ratio card
Draw the Mentholum of glue and formula ratio, add dehydrated alcohol constant volume, stir, sterilizing, coating-dividing sealing, obtain full-service fluid
Dressing.
The invention have the benefit that
1, on the one hand, by polyvinyl butyral resin-polyvidone as filmogen, owing to polyvinyl butyral resin is one
Plant preferable film former, wound surface can be made to form one layer of protection with the good transparency, elasticity, pliability, toughness
Film, the transparent shape of this protecting film, it is simple to observe wound healing situation, stop that external microbe invasion wound is to cause two to wound
Secondary pollution, protecting film creates hypoxia or micro-acid environment of relative anaerobic, wound bacterial reproduction can be made to be suppressed, be conducive to
Fibroblastic growth and blood vessel hyperplasia, be therefore more conducive to accelerate wound healing；Second aspect, the present invention contains alginic acid
Sodium-polyvinylpyrrolidone, the liquid dressing that sodium alginate obtains after being blended with polyvinylpyrrolidone, its water absorbing capacity exceedes
16 times of deadweight, and there is 287.24g/ (m2.h) moisture-vapor transmission so that the protecting film waterproof and breathable of the present invention, with
Time, with polyvinyl butyral resin synergism, polyvinylpyrrolidone can promote that polyvinyl butyral resin quickly forms protecting film,
Sodium alginate can carry out ion exchange with the body fluid of wound surface, and sodium alginate dissolves in body fluid so that the protection of wound surface
Film is easily removed, and does not results in-the COOH on patient's secondary damage, and its macromolecular chain of alginate anti-with the NaCl in blood
Should, the ionization equilibrium making blood is unbalance, have activated thrombin simultaneously, plays hemostatic function；The third aspect, the present invention contains carboxylic
Methyl cellulose sodium, carboxymethyl cellulose sodium has the strongest autolytic debridement ability, can understand the slough of wound surface, absorbs big
The transudate of amount and harmful substance, prevent traumatic infection, promotes wound healing, and carboxymethyl cellulose sodium coordinates polyvinyl alcohol contracting fourth
Aldehyde, can form low oxygen power, stimulating expression of macrophage and the release of interleukin at wound, promotes wound local blood circulation
Accelerate, with alleviating pain sense；Fourth aspect, the present invention contains nanometer silver-chitosan, has the function of anti-inflammation and sterilization, nanometer silver
Antibacterial have broad spectrum activity, high efficiency and persistency, no side effects, and chitosan has slow releasing function, can ease the pain, have
Bacteriostasis, nanometer silver is combined with chitosan, can be formed and a kind of have high, the good biocompatibility of physical property and antibacterial disappear
The mixture of inflammatory；5th aspect, the present invention contains a small amount of carrageenan, can play thickening efficiency, and carrageenan energy and alginic acid
Sodium is blended, and forms the alginate fiber of good biocompatibility under the effect of cross-linking agent, and this fibrous mechanical property is good so that this
Invention has promotion cell regeneration function, thus accelerates wound healing；6th aspect, the present invention contains Mentholum, has hemostasis
Function, prevents wound from bleeding, and has refrigerant antipruritic function, prevents the pruritus during wound healing；7th aspect, this
Dehydrated alcohol selected by bright solvent, and polyvinyl butyral resin film property in dehydrated alcohol is the most excellent so that film forming of the present invention
Effective, and other components of the present invention are all dissolved in dehydrated alcohol, therefore use dehydrated alcohol as solvent, can form one surely
Fixed uniform solution system so that stable in properties of the present invention, effective；Eighth aspect, the content of each component of the present invention, can promote
Each component preferably plays synergism to promote action effect, and owing to more expensive constituent content is less, reduces the present invention
Production cost.
2, the model of polyvinyl butyral resin is viscosity 250CPS～280CPS or 10s～15s, and polyvinyl butyral resin glues
Spending little, fragility is little, good film-forming property；The specification of described polyvinylpyrrolidone is K15～K25, and polyvinylpyrrolidone K value is relatively
Little, sterically hindered little, easily cross-link with polyvinyl butyral resin and form molecule hole, pore is effective.
3, the preparation method of full-service fluid dressing of the present invention, the method technique is simple, preparation cost is low, many merits of preparation
Can liquid dressing stable performance, effect notable.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated.
Embodiment 1:
Full-service fluid dressing, in parts by mass, component is polyvinyl butyral resin 2-8 part, sodium alginate-polyethylene pyrrole
Pyrrolidone 0.5-0.8 part, nanometer silver-chitosan 0.2-0.6 part, sodium carboxymethyl cellulose 0.1-0.4 part, carrageenan 0.1-0.4
Part, Mentholum 0.1-0.4 part and dehydrated alcohol 91-97 part.
In the present embodiment, sodium alginate and the matter of polyvinylpyrrolidone in described sodium alginate-polyvinylpyrrolidone
Amount ratio is 1:3.
In the present embodiment, the model of described polyvinyl butyral resin is viscosity 260CP, the rule of described polyvinylpyrrolidone
Lattice are K22.
In the present embodiment, in parts by mass, component is polyvinyl butyral resin 4 parts, sodium alginate-polyvinylpyrrolidone
0.5 part, nanometer silver-chitosan 0.4 part, sodium carboxymethyl cellulose 0.1 part, carrageenan 0.1 part, Mentholum 0.1 part and anhydrous second
Alcohol 94.8 parts.
The preparation method of full-service fluid dressing, comprises the following steps:
1. weigh the polyvinyl butyral resin of formula ratio, be dissolved in dehydrated alcohol, stir, prepare film forming solution；
2. weigh the sodium alginate-polyvinylpyrrolidone of formula ratio, be dissolved in dehydrated alcohol, stir, prepare pore
Solution；
3. weigh nanometer silver and the chitosan of formula ratio, be dissolved in dehydrated alcohol, stir, prepare germicidal solution；
4. take step 1. in film forming solution, step 2. in pore solution, step 3. in germicidal solution, stirring is all
Even, obtain mixed liquor；
5. take step 4. in mixed liquor, be added thereto to formula ratio sodium carboxymethyl cellulose, add formula ratio card
Draw the Mentholum of glue and formula ratio, add dehydrated alcohol constant volume, stir, sterilizing, coating-dividing sealing, obtain multifunctional solution
Body dressing.
Embodiment 2:
Full-service fluid dressing, in parts by mass, component is polyvinyl butyral resin 2-8 part, sodium alginate-polyethylene pyrrole
Pyrrolidone 0.5-0.8 part, nanometer silver-chitosan 0.2-0.6 part, sodium carboxymethyl cellulose 0.1-0.4 part, carrageenan 0.1-0.4
Part, Mentholum 0.1-0.4 part and dehydrated alcohol 91-97 part.
In the present embodiment, sodium alginate and the matter of polyvinylpyrrolidone in described sodium alginate-polyvinylpyrrolidone
Amount ratio is 1:3.
In the present embodiment, the model of described polyvinyl butyral resin is viscosity 270CP, the rule of described polyvinylpyrrolidone
Lattice are K24.
In the present embodiment, in parts by mass, component is polyvinyl butyral resin 6 parts, sodium alginate-polyvinylpyrrolidone
0.6 part, nanometer silver-chitosan 0.5 part, sodium carboxymethyl cellulose 0.1 part, carrageenan 0.1 part, Mentholum 0.1 part and anhydrous second
Alcohol 92.6 parts.
The preparation method of full-service fluid dressing, comprises the following steps:
1. weigh the polyvinyl butyral resin of formula ratio, be dissolved in dehydrated alcohol, stir, prepare film forming solution；
2. weigh the sodium alginate-polyvinylpyrrolidone of formula ratio, be dissolved in dehydrated alcohol, stir, prepare pore
Solution；
3. weigh nanometer silver and the chitosan of formula ratio, be dissolved in dehydrated alcohol, stir, prepare germicidal solution；
4. take step 1. in film forming solution, step 2. in pore solution, step 3. in germicidal solution, stirring is all
Even, obtain mixed liquor；
5. take step 4. in mixed liquor, be added thereto to formula ratio sodium carboxymethyl cellulose, add formula ratio card
Draw the Mentholum of glue and formula ratio, add dehydrated alcohol constant volume, stir, sterilizing, coating-dividing sealing, obtain full-service fluid
Dressing.
Embodiment 3
Full-service fluid dressing, in parts by mass, component is polyvinyl butyral resin 2-8 part, sodium alginate-polyethylene pyrrole
Pyrrolidone 0.5-0.8 part, nanometer silver-chitosan 0.2-0.6 part, sodium carboxymethyl cellulose 0.1-0.4 part, carrageenan 0.1-0.4
Part, Mentholum 0.1-0.4 part and dehydrated alcohol 91-97 part.
In the present embodiment, sodium alginate and the matter of polyvinylpyrrolidone in described sodium alginate-polyvinylpyrrolidone
Amount ratio is 1:3.
In the present embodiment, the model of described polyvinyl butyral resin is viscosity 280CP, the rule of described polyvinylpyrrolidone
Lattice are K25.
In the present embodiment, in parts by mass, component is polyvinyl butyral resin 6 parts, sodium alginate-polyvinylpyrrolidone
0.6 part, nanometer silver-chitosan 0.5 part, sodium carboxymethyl cellulose 0.1 part, carrageenan 0.1 part, Mentholum 0.1 part and anhydrous second
Alcohol 92.6 parts.
The preparation method of full-service fluid dressing, comprises the following steps:
1. weigh the polyvinyl butyral resin of formula ratio, be dissolved in dehydrated alcohol, stir, prepare film forming solution；
2. weigh the sodium alginate-polyvinylpyrrolidone of formula ratio, be dissolved in dehydrated alcohol, stir, prepare pore
Solution；
3. weigh nanometer silver and the chitosan of formula ratio, be dissolved in dehydrated alcohol, stir, prepare germicidal solution；
4. take step 1. in film forming solution, step 2. in pore solution, step 3. in germicidal solution, stirring is all
Even, obtain mixed liquor；
5. take step 4. in mixed liquor, be added thereto to formula ratio sodium carboxymethyl cellulose, add formula ratio card
Draw the Mentholum of glue and formula ratio, add dehydrated alcohol constant volume, stir, sterilizing, coating-dividing sealing, obtain full-service fluid
Dressing.
In above-mentioned 3 embodiments, the source of each component is: polyvinyl butyral resin derives from Tianjin Hua Changyuan Chemical trade
Company limited；Polyvinylpyrrolidone derives from Guangdong, Guangzhou and beautifies work；Nanometer silver derives from Changzhou limited public affairs of English-Chinese nanosecond science and technology
Department, chitosan derives from Sanland Chemical Co, LTD, USA；Sodium alginate derives from Lianyun Harbour global Sargassum auxiliary agent to be had
Limit company.
Matched group
The liquid adhesive bandage of the most a certain generic brand is as comparison.
Pharmaceutical properties is tested:
For verifying effect of above-mentioned full-service fluid dressing, now measuring every physical and chemical parameter, measurement result is as shown in table 1:
Interpretation of result:
Relative to matched group, the full-service fluid dressing of the present invention, film formation time is short, within a short period of time, can be at wound
Surface forms protective filmy layer；This protecting film water absorption rate is high, air penetrability is high so that protecting film has the performance of waterproof and breathable；Right
Gold-coloured staphylococci, gram positive bacteria, gram negative bacteria etc. have ability of preferably killing, and antiphlogistic antibacterial of the present invention is described
Effective, traumatic infection and suppuration can be prevented；The present invention has analgesia function, the misery of energy reduction of patient；The wound healing time
Short, illustrate that the present invention has the function promoting wound healing.
Effect of drugs is tested:
Subjects: 12 skin trauma reasons, wound degree, patient that wound area is the most identical, is divided into 4 groups, often organizes 3
People；Skin trauma reason is when cutting fruit that left index finger is by incised wound, and wound area is 1cm2～1.5cm2, wound has bleeds.
Test method: the full-service fluid dressing of Example 1, is sprayed on respectively by the consumption of every square centimeter of 0.3ml
3 patients's wound skin surface (patient age is similar) of one group, the full-service fluid dressing of Example 2, by every square li
The consumption of rice 0.3ml is sprayed on patient's wound skin surface (patient age is similar) of 3 of second group respectively, Example 3
Full-service fluid dressing, 3 the patient's wound skin surfaces being sprayed on the 3rd group by the consumption of every square centimeter of 0.3ml respectively (are suffered from
Person is of the similar age), the liquid bandage taking matched group is pasted on 3 patient's wound skin surface (patient age phases of the 4th group
Imitative)；To each group of wound Continuous Observation 5 days, observe wound film forming situation and skin repair situation.
Result of the test: in each embodiment and matched group, film formation time and wound are as shown in table 21 for repair time,
Table 2: film formation time and wound statistical table repair time
| Index | Embodiment 1 | Embodiment 2 | Embodiment 3 | Matched group |
| Film formation time (min) | About 1.5 | About 1.2 | About 1.1 | / |
| Film body form | Smooth | Smooth | Smooth | / |
| Wound healing time (d) | 3.2 | 2.5 | 2.8 | 5.5 |
| Wound is visual | Visually | Visually | Visually | Not visible |
| Change dressings frequency (d) | It is not required to change dressings | It is not required to change dressings | It is not required to change dressings | 2 |
| Cicatrix situation | Nothing | Nothing | Nothing | Have |
| Hemostasis | Stop blooding immediately | Stop blooding immediately | Stop blooding immediately | Effect is the most notable |
| Untoward reaction | Nothing | Nothing | Nothing | Pruritus |
Interpretation of result:
After the full-service fluid dressing of the present invention is sprayed on wound surface, can stop blooding immediately, within a short period of time is at wound table
Face forms layer protecting film, and the protecting film formed is smooth, and for the little wound in this test, without changing after spray once
Medicine, through getting final product wound healing after a few days, relative to the liquid bandage of matched group, present invention hemostasis, antiinflammatory, bactericidal effect
Get well, have no adverse reaction, wound visual, be not required to change dressings, wound healing is fast, preventing from scar.
The highest simultaneously for the full-service fluid dressing of variable concentrations, film former and porogen concentration, film formation time is more
Short, the wound healing time is the shortest, owing to film former can form layer protecting film at wound surface, plays isolation microorganism, waterproof
Effect, prevent cross infection, the addition of porogen, add the breathability of protecting film, promote wound healing.
Embodiment described above only have expressed the several embodiments of the present invention, and it describes more concrete and detailed, but also
Therefore the restriction to the scope of the claims of the present invention can not be interpreted as.It should be pointed out that, for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, it is also possible to make some deformation and improvement, these broadly fall into the guarantor of the present invention
Protect scope.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (7)
1. full-service fluid dressing, it is characterised in that: in parts by mass, component is polyvinyl butyral resin 2-8 part, alginic acid
Sodium-polyvinylpyrrolidone 0.5-0.8 part, nanometer silver-chitosan 0.2-0.6 part, sodium carboxymethyl cellulose 0.1-0.4 part, card
Draw glue 0.1-0.4 part, Mentholum 0.1-0.4 part and dehydrated alcohol 91-97 part.
Full-service fluid dressing the most according to claim 1, it is characterised in that: described sodium alginate-polyvinylpyrrolidine
In ketone, sodium alginate is 1:3 with the mass ratio of polyvinylpyrrolidone.
Full-service fluid dressing the most according to claim 2, it is characterised in that: the model of described polyvinyl butyral resin is
Viscosity 250CPS～280CPS or 10s～15s；The specification of described polyvinylpyrrolidone is K20～K25.
Full-service fluid dressing the most according to claim 3, it is characterised in that: in parts by mass, component is polyvinyl alcohol
Butyral 4 parts, sodium alginate-polyvinylpyrrolidone 0.5 part, nanometer silver-chitosan 0.4 part, sodium carboxymethyl cellulose 0.1
Part, carrageenan 0.1 part, Mentholum 0.1 part and dehydrated alcohol 94.8 parts.
Full-service fluid dressing the most according to claim 3, it is characterised in that: in parts by mass, component is polyvinyl alcohol
Butyral 6 parts, sodium alginate-polyvinylpyrrolidone 0.6 part, nanometer silver-chitosan 0.5 part, sodium carboxymethyl cellulose 0.1
Part, carrageenan 0.1 part, Mentholum 0.1 part and dehydrated alcohol 92.6 parts.
Full-service fluid dressing the most according to claim 3, it is characterised in that: in parts by mass, component is polyvinyl alcohol
Butyral 6 parts, sodium alginate-polyvinylpyrrolidone 0.6 part, nanometer silver-chitosan 0.5 part, sodium carboxymethyl cellulose 0.1
Part, carrageenan 0.1 part, Mentholum 0.1 part and dehydrated alcohol 92.6 parts.
7. the preparation method of full-service fluid dressing, it is characterised in that: comprise the following steps:
1. weigh the polyvinyl butyral resin of formula ratio, be dissolved in dehydrated alcohol, stir, prepare film forming solution；
2. weigh the sodium alginate-polyvinylpyrrolidone of formula ratio, be dissolved in dehydrated alcohol, stir, prepare pore solution；
3. weigh nanometer silver and the chitosan of formula ratio, be dissolved in dehydrated alcohol, stir, prepare germicidal solution；
4. take step 1. in film forming solution, step 2. in pore solution, step 3. in germicidal solution, stir,
To mixed liquor；
5. take step 4. in mixed liquor, be added thereto to formula ratio sodium carboxymethyl cellulose, add formula ratio carrageenan
With the Mentholum of formula ratio, add dehydrated alcohol constant volume, stir, sterilizing, coating-dividing sealing, obtain full-service fluid and apply
Material.
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| CN201610553348.2A CN106139239A (en) | 2016-07-12 | 2016-07-12 | Full-service fluid dressing and preparation method thereof |
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| CN106727446A (en) * | 2016-12-26 | 2017-05-31 | 广州立白企业集团有限公司 | Film-forming composition, diaphragm and application |
| CN107137380A (en) * | 2017-06-12 | 2017-09-08 | 盐城卫生职业技术学院 | Temperature adjustment bactericidal composition and preparation method thereof and bandage and preparation method thereof |
| CN107281542A (en) * | 2017-06-25 | 2017-10-24 | 长沙善道新材料科技有限公司 | A kind of liquid adhesive bandage of anti-pigment deposition and preparation method thereof |
| CN108641104A (en) * | 2018-04-11 | 2018-10-12 | 中国人民解放军第七医院 | A kind of water base cross-linked polymer and its preparation method and application |
| CN109821063A (en) * | 2019-04-09 | 2019-05-31 | 上海创宏生物科技有限公司 | A kind of liquid molding agent and its preparation method and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106727446A (en) * | 2016-12-26 | 2017-05-31 | 广州立白企业集团有限公司 | Film-forming composition, diaphragm and application |
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| CN107137380A (en) * | 2017-06-12 | 2017-09-08 | 盐城卫生职业技术学院 | Temperature adjustment bactericidal composition and preparation method thereof and bandage and preparation method thereof |
| CN107137380B (en) * | 2017-06-12 | 2020-08-07 | 盐城卫生职业技术学院 | Temperature-regulating and sterilizing composition and preparation method thereof, and adhesive bandage and preparation method thereof |
| CN107281542A (en) * | 2017-06-25 | 2017-10-24 | 长沙善道新材料科技有限公司 | A kind of liquid adhesive bandage of anti-pigment deposition and preparation method thereof |
| CN107281542B (en) * | 2017-06-25 | 2020-11-13 | 长沙善道新材料科技有限公司 | Liquid band-aid capable of preventing pigmentation and preparation method thereof |
| CN108641104A (en) * | 2018-04-11 | 2018-10-12 | 中国人民解放军第七医院 | A kind of water base cross-linked polymer and its preparation method and application |
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