CN105078651A - Multifunctional wet medical wound dressing and preparation method thereof - Google Patents
Multifunctional wet medical wound dressing and preparation method thereof Download PDFInfo
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- CN105078651A CN105078651A CN201510500878.6A CN201510500878A CN105078651A CN 105078651 A CN105078651 A CN 105078651A CN 201510500878 A CN201510500878 A CN 201510500878A CN 105078651 A CN105078651 A CN 105078651A
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- Epidemiology (AREA)
- Materials Engineering (AREA)
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- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention relates to a multifunctional wet medical wound dressing and a preparation method thereof. The multifunctional wet medical wound dressing comprises a polyethylene release film layer, a polyurethane thin film layer, a medical pressure-sensitive adhesive layer, a multifunctional hydrogel layer, a release paper layer and a release paper tearing opening formed in the release paper layer, wherein the polyethylene release film layer, the polyurethane thin film layer, the medical pressure-sensitive adhesive layer, the multifunctional hydrogel layer and the release paper layer are sequentially laminated. The invention further provides the preparation method of the multifunctional wet medical wound dressing. By the adoption of the multifunctional wet medical wound dressing and the preparation method thereof, the effects of being water resistible and breathable, achieving hemostasis and bacteriostasis, diminishing inflammation and stopping pains are achieved; a closed moist environment can be kept around the surface of a wound and in a wound surface area, no toxic and side effects exist, the texture is soft and elastic, the mechanical property is good, and great practical value is achieved.
Description
Technical field
The present invention relates to medical applications, particularly medical dressing, specifically refer to a kind of Multifunctional Moisture medical wound dressing and preparation method thereof.
Background technology
Wound repair is the bioprocess that body response skin injury one of showing is complicated, mainly comprises the local inflammation stage of reaction, cell proliferation stage and tissue reconstruction stage.The change of local environment, comprising wound local various cell, extracellular matrix and growth factor etc. must interact, and has great impact to wound healing.Wet wound healing is the theory of scientists through 30 or 40 years Researching and practicing formation, and namely epithelial cell could must grow fast under moistening environment, and wound healing rate when moistening is accelerated.
Moistening healing is the main trend of following trauma care and Wound care, therefore creates moistening healing environment, promotes wound healing, reduces to infect probability, the generation of minimizing cicatrix and reduce and look after the primary condition that cost etc. is an advanced dressing.And the volume production technology of the inner face material of dynamical absorbing material, high bio-compatibility, water-proof antibiotic coating surfacing and advanced person determines the successful key of advanced dressing commercialization.
The development of present dressing is very fast, but does not still have a kind of dressing can reach the requirement of desirable dressing at present.Traditional dressing is as good in cystose dressing absorbability, water vapo(u)r transmission is good, but it can bring secondary damage to wound, and leaves over detritus in wound surface; Film dressing can stop bacteriological infection, provides gas exchange, have the advantages such as good mechanical performance, but the too little and easy hydrops of its moisture-vapor transmission.All have various deficiency, various new material dressing also emerges in an endless stream, and as dressing such as glue, hydrogel, polymeric membrane and artificial skin, it all belongs to the dressing of wet wound healing type.There is the interaction of multiple pattern between dressing and wound, as absorbed sepage and noxious substance, permission gas exchange, and is the desirable environment of healing creation one; Barrier layer structure, to prevent in environment microorganism invasion, and prevention wound cross infection etc. are multi-functional, wherein has more transparent, soft, moisture absorption with aerogel dressing again, breathes freely and to prevent in environment the characteristics such as microorganism invasion.Hydrogel medical dressing is a kind of novel wound dressing that development in recent years is got up, it is the novel biomaterial that a class performance is better than traditional dressing and biological dressing, can promote that wound heals better, alleviate the pain of patient, it can improve the microenvironment of wound surface, the growth of anti-bacteria, has investigation and application widely at biomedical engineering field.
Desirable medical dressing except to protect wound by secondary damage, provide benefit wound healing moist environment, prevent excessively scattering and disappearing of moisture and body fluid, also should possess and protect from infection and the performance such as acceleration of tissue repair process.But the level of present medical dressing does not also reach above-mentioned level far away.
Summary of the invention
The object of the invention is to overcome shortcoming of the prior art, Multifunctional Moisture wound dressing that a kind of waterproof and breathable, hemostatic bacteriostatic, anti-inflammatory analgetic are provided and preparation method thereof.
To achieve these goals, first aspect present invention provides the dressing of a kind of Multifunctional Moisture medical wound, it is characterized in that, comprise the polyethylene release film layer, thin polyurethane rete, medical pressure-sensing glue-line, multifunctional water gel layer, the off-style paper layer that stack gradually, and be located at the release paper tearing notch on described off-style paper layer.Wherein polyethylene release film layer and thin polyurethane rete are combined into PU layer.
Preferably, described multifunctional water gel layer comprises the composition of following mass percent:
Glycerol 15-25%;
Polyethylene Glycol 5-15%;
Polyvinylpyrrolidone 2-8%;
Hemostatic bacteriostatic agent 5-15%;
Deionized water 40-70%.
More preferably, described hemostatic bacteriostatic agent is water-soluble chitosan.
Preferably, the thickness of described multifunctional water gel layer is between 0.2-0.4mm.
Preferably, the preparation method of described multifunctional water gel layer comprises the following steps:
Step (1): be dissolved in by glycerol in distilled water and be configured to the first solution, is dissolved in polyvinylpyrrolidone in distilled water and is configured to the second solution, hemostatic bacteriostatic agent is dissolved in distilled water and is configured to the 3rd solution;
Step (2): by the first described solution, the second described solution, the 3rd described solution mixing, add Polyethylene Glycol, be placed in autoclave sterilizer heating and obtain the 4th solution;
Step (3): medical thermoplastic polyurethane (TPU) film is laid on the irradiation plate of covering one deck preservative film, the 4th described solution is painted on after in TPU membrane, adopt electron beam irradiation, obtain the rete after irradiation;
Step (4): freezingly under described rete being placed in-5 DEG C to 5 DEG C conditions be placed on 15-35 DEG C of environment, is cycled to repeat repeatedly, obtains described multifunctional water gel layer.
Preferably, described multifunctional water gel layer comprises the composition of following mass percent:
Glycerol 18-25%, is more preferably 20-23%;
Polyethylene Glycol 8-15%, is more preferably 10-12%;
Polyvinylpyrrolidone 5-8%;
Hemostatic bacteriostatic agent 5-10%, is more preferably 6-8%;
Deionized water 40-70%, is more preferably 50-60%.
Second aspect present invention provides a kind of preparation method according to the dressing of above-mentioned Multifunctional Moisture medical wound, it is characterized in that, comprises the following steps:
Step (1): polyethylene release film layer, thin polyurethane rete, medical pressure-sensing glue-line are stacked gradually the PU film of laminating formation with medical pressure-sensing glue-line;
Step (2): fitted by the medical pressure-sensing glue layer of the upper surface of multifunctional water gel layer and described PU film, fits described multifunctional water gel layer lower surface and the off-style paper layer be provided with from paper mold tearing notch, obtains semi-finished product of fitting;
Step (3): described laminating semi-finished product are cut into sheet-like hydrous gel according to setting specification, obtains Multifunctional Moisture wound dressing semi-finished product;
Step (4): by sterilizing after described semi finished package, obtains described Multifunctional Moisture wound dressing.
Adopt Multifunctional Moisture medical wound of the present invention dressing and preparation method thereof, its waterproof and breathable, hemostatic bacteriostatic, anti-inflammatory analgetic, extremely have use value, and it can make around wound surface and wound surface district keeps closed moist environment, without any side effects; Quality softness is flexible, good mechanical property; Have very strong liquid-absorbent, 2 times of transudates of Absorbable rod own vol, namely move back sticky after imbibition, effectively prevent the wound again of wound tissue; There is splendid ductility, good with tissue attaching property, be specially adapted to the crooked position of the activities such as joint, make wound tissue produce constant moisture and happy curative effect, significantly reduce pain; Hemostatic bacteriostatic, prevents bacterial micro-organism from invading, prevention infection, for wound surface structure provides a good reparation platform, can effectively promote wound tissue quickly-healing.Its preparation method, technique is simple, is easy to industrialization, is applicable to the quick procedure for producing of continuous industryization, can effectively reduces costs, and improves yield.
Accompanying drawing explanation
Fig. 1 and Fig. 2 is the structure of the Multifunctional Moisture medical wound dressing in the embodiment of the present invention.
Detailed description of the invention
In order to more clearly understand technology contents of the present invention, below specific embodiment of the invention method is described further.
As depicted in figs. 1 and 2; Multifunctional Moisture wound dressing of the present invention; the multifunctional water gel comprised as main body applies core 4; the upper surface that described multifunctional water gel applies core 4 is pasted with the transparent plastic protecting film (i.e. polyethylene 1/ polyurethane 2 composite membrane) that one deck scribbles medical pressure-sensitive adhesive 3, and the lower surface stickup that described multifunctional water gel applies core 4 is provided with the release paper protective layer 5 facilitating tearing notch 6.
Hydrogel applies core (multifunctional water gel layer), utilize the hydrophilic group in hydrogel structure to absorb wound exudate and evacuation of pus, form the semi-solid material of similar gels, be attached to wound base portion, prevent wound dehydrates, provide and maintain the moist environment of wound healing; Utilize its viscosity to form the healing environment of wound surface enclosed, prevent bacterial micro-organism from invading, prevention infection.Hydrogel layer is water white transparency, is convenient to the recovery situation observing wound surface like this.
Glycerol has hygroscopicity, and therefore obtained multifunctional water gel has very strong liquid-absorbent.Polyethylene Glycol has antibacterial, plasticization, has excellent moisture retention, dispersibility, lubricity, bonding agent and softening agent etc., and for U.S. FDA approval medical material.By changing the material proportion of glycerol and Polyethylene Glycol, solving mechanical property and the absorbent of hydrogel, maintaining the moist environment of wound surface, effectively prevent the damage again of wound tissue, be conducive to wound surface quickly-healing.Polyvinylpyrrolidone is a kind of synthesizing water-solubility macromolecular compound, has the general aspects of water-soluble high-molecular compound, colloid protective effect, film property, caking property, hygroscopicity, solubilising or cohesion.Polyvinylpyrrolidone is both water-soluble, is dissolved in majority of organic solvent again, has excellent physiological inertia and biocompatibility, and toxicity is very low, does not produce any stimulation to skin, mucosa, eye etc.By changing its content in multifunctional water gel, the film property of controlled controlling the water circulation gel and viscosity.Deionized water, for regulating concentration during each component cross-link, also can regulate the moist of hydrogel in addition.Hemostatic bacteriostatic agent as chitosan, then makes hydrogel layer have hemostasis, antiinflammatory, sterilizing, promotion wound healing, absorb the effect such as Wound exudate, not easily syneresis, can also figuration, and hydrogel layer can be made to form moist g., jelly-like material.
Embodiment 1
Step (1): glycerol is dissolved in appropriate distilled water, is made into solution A; Polyvinylpyrrolidone is dissolved in appropriate distilled water, joins to obtain B solution; Chitosan is dissolved in appropriate distilled water, joins to obtain C solution.
Step (2): above-mentioned three kinds of solution are pressed different proportion mixing, then add a certain amount of PEG400, shake up, is then placed in the solution D that autoclave sterilizer 125 DEG C heating 2h obtains mix homogeneously.
Step (3): TPU membrane be laid on the irradiation plate of covering one deck preservative film, uses brush a certain amount of solution D to be painted in TPU membrane.
Step (4): adopt electron beam irradiation, beam energy is 10MeV, and electric current is 8.5mA, and device transmission speed is 3m/min, and irradiation dose is 42kGy.
Step (5): put into-20 DEG C of refrigerator freezings after irradiation terminates 4 hours, to be then placed at room temperature 25 DEG C 2 hours, to be cycled to repeat 2 times, to obtain the hydrogel layer of thickness 0.4mm.The multifunctional water gel prepared is placed in 4 DEG C of Refrigerator stores.Hydrogel layer specification is 5cm × 5cm, and the percentage by weight composition of each component of hydrogel layer sees the following form 1.
Step (6): the transparent plastic protecting film (i.e. polyethylene/polyurethane composite membrane) scribbling medical pressure-sensitive adhesive on hydrogel layer upper surface is pasted; the release paper protective layer facilitating tearing notch is provided with on hydrogel layer lower surface is pasted; after gamma-ray irradiation sterilizing, obtain Multifunctional Moisture wound dressing.
Embodiment 2:
Step (1): glycerol is dissolved in appropriate distilled water, is made into solution A; Polyvinylpyrrolidone is dissolved in appropriate distilled water, joins to obtain B solution; Chitosan is dissolved in appropriate distilled water, joins to obtain C solution.
Step (2): above-mentioned three kinds of solution are pressed different proportion mixing, then add a certain amount of PEG400, shake up, is then placed in the solution D that autoclave sterilizer 120 DEG C heating 3h obtains mix homogeneously.
Step (3): TPU membrane be laid on the irradiation plate of covering one deck preservative film, uses brush a certain amount of solution D to be painted in TPU membrane.
Step (4): adopt electron beam irradiation, beam energy is 10MeV, and electric current is 8.5mA, and device transmission speed is 3m/min, and irradiation dose is 38kGy.
Step (5): put into-10 DEG C of refrigerator freezings after irradiation terminates 2 hours, to be then placed at room temperature 25 DEG C 2 hours, to be cycled to repeat 2 times, to obtain the hydrogel layer of thickness 0.3mm.The multifunctional water gel prepared is placed in 4 DEG C of Refrigerator stores.Hydrogel layer specification is 5cm × 14cm, and the percentage by weight composition of each component of hydrogel layer sees the following form 1.
Step (6): the transparent plastic protecting film (i.e. polyethylene/polyurethane composite membrane) scribbling medical pressure-sensitive adhesive on hydrogel layer upper surface is pasted; the release paper protective layer facilitating tearing notch is provided with on hydrogel layer lower surface is pasted; after gamma-ray irradiation sterilizing, obtain Multifunctional Moisture wound dressing.
Embodiment 3:
Step (1): glycerol is dissolved in appropriate distilled water, is made into solution A; Polyvinylpyrrolidone is dissolved in appropriate distilled water, joins to obtain B solution; Chitosan is dissolved in appropriate distilled water, joins to obtain C solution.
Step (2): above-mentioned three kinds of solution are pressed different proportion mixing, then add a certain amount of PEG400, shake up, is then placed in the solution D that autoclave sterilizer 130 DEG C heating 1.5h obtains mix homogeneously.
Step (3): TPU membrane be laid on the irradiation plate of covering one deck preservative film, uses brush a certain amount of solution D to be painted in TPU membrane.
Step (4): adopt electron beam irradiation, beam energy is 10MeV, and electric current is 8.5mA, and device transmission speed is 3m/min, and irradiation dose is 30kGy.
Step (5): put into-15 DEG C of refrigerator freezings after irradiation terminates 3 hours, to be then placed at room temperature 25 DEG C 2 hours, to be cycled to repeat 2 times, to obtain the hydrogel layer of thickness 0.35mm.The multifunctional water gel prepared is placed in 4 DEG C of Refrigerator stores.Hydrogel layer specification is 10cm × 10cm, and the percentage by weight composition of each component of hydrogel layer sees the following form 1.
Step (6): the transparent plastic protecting film (i.e. polyethylene/polyurethane composite membrane) scribbling medical pressure-sensitive adhesive on hydrogel layer upper surface is pasted; the release paper protective layer facilitating tearing notch is provided with on hydrogel layer lower surface is pasted; after gamma-ray irradiation sterilizing, obtain Multifunctional Moisture wound dressing.
Embodiment 4:
Step (1): glycerol is dissolved in appropriate distilled water, is made into solution A; Polyvinylpyrrolidone is dissolved in appropriate distilled water, joins to obtain B solution; Chitosan is dissolved in appropriate distilled water, joins to obtain C solution.
Step (2): above-mentioned three kinds of solution are pressed different proportion mixing, then add a certain amount of PEG400, shake up, is then placed in the solution D that autoclave sterilizer 125 DEG C heating 2h obtains mix homogeneously.
Step (3): TPU membrane be laid on the irradiation plate of covering one deck preservative film, uses brush a certain amount of solution D to be painted in TPU membrane.
Step (4): adopt electron beam irradiation, beam energy is 10MeV, and electric current is 8.5mA, and device transmission speed is 3m/min, and irradiation dose is 35kGy.
Step (5): put into-20 DEG C of refrigerator freezings after irradiation terminates 4 hours, to be then placed at room temperature 25 DEG C 2 hours, to be cycled to repeat 2 times, to obtain the hydrogel layer of thickness 0.4mm.The multifunctional water gel prepared is placed in 4 DEG C of Refrigerator stores.Hydrogel layer specification is 10cm × 20cm, and the percentage by weight composition of each component of hydrogel layer sees the following form 1.
Step (6): the transparent plastic protecting film (i.e. polyethylene/polyurethane composite membrane) scribbling medical pressure-sensitive adhesive on hydrogel layer upper surface is pasted; the release paper protective layer facilitating tearing notch is provided with on hydrogel layer lower surface is pasted; after gamma-ray irradiation sterilizing, obtain Multifunctional Moisture wound dressing.
The percentage by weight composition of each component of table 1 hydrogel layer:
The present invention is disposable sterile product, will notice that product list packaging is necessary for the unabroken state of sealing, if there is breakage not use before using.The Multifunctional Moisture wound dressing of dimension is selected according to wound surface size; tear along packaging bag opening and take out this product; release paper is opened along tearing notch; hydrogel face is affixed on cleaned wound location; guarantee that dressing covers wound completely; press gently, then remove outer transparent plastic protecting film.Can combinationally use with sterile gauze or binder, also can as required fixation adhesive tape be cut into corresponding size with the use of.Use in time behind Kaifeng, do not reuse.The present invention is applicable to otch or the wound surface such as skin trauma, skin ulcer (comprising decubital ulcer, tuberculosis, mycete, fungal infection etc.), I degree or shallow II degree burn wound, scald, incised wound, various surgical operation and plastic operation; also be applicable to indwelling artery and vein conduit and stick use, and infant umbilical cord protecting wound surface etc.
The change of dressing time is how many and determine according to wound fluid, when sepage is more, according to circumstances change in time or replacing in 1 ~ 2 hour once; When sepage is less or nothing is oozed out, within 2-3 days, change once, until healing.If patient is exposed to wound surface in the environment of especially dry or high temperature, the present invention includes the depletion rate of effective ingredient can than faster under room temperature.
Points for attention:
1. normal saline or iodine tincture Sterile surgery or traumatic surface and surrounding skin should be used if desired before use, in case infect.
2. the present invention is sterile product, can only single use, packages in damaged condition or exceed useful life, prohibits the use.3. use and appropriate to the occasionly exceed wound surface edge 0.5cm, to guarantee that multifunctional water gel can flap coverage completely.Sealing is singly packed and is just lost aseptic immediately once opening, therefore needs to use as soon as possible in time.
4. sticky by automatically moving back after dressing absorbs transudate, should change in time, to maintain the environment that wound effectively heals.
5. the present invention is hypoallergenic product, generally there will not be allergic phenomena.As there is allergic phenomena or uncomfortable reaction, should doctor be submitted in time to dispose.
6. the present invention is sterile product, should aseptically use.
Product standard and the method for inspection:
This standard specifies Multifunctional Moisture wound dressing of the present invention, forms, not pastille by scribbling the polyurethane/polyethylene composite film (be called for short PU film) of medical pressure-sensitive adhesive, multifunctional water gel and release paper.
1, outward appearance
With visual observations and touch inspection.Multifunctional Moisture wound dressing and single packaging bag surface should smooth, free from smutting during, without damaged, hydrogel layer should be coated with uniform ground, without starved phenomenon.Colloid part answers water white transparency, and PU film, hydrogel layer, release paper must not have break-off.
2, size
With general gage measuring.Size conforms design code of the present invention, given size ± the 2mm margin of tolerance in.
3, viscosity is held
According in Appendix B in YY/T0148-2006 the B.2 chapter test time, duration of test in baking oven, the top being affixed on adhesive film on corrosion resistant plate glides and should be no more than 2.5mm.
4, breathability
Test according to " water vapo(u)r transmission test method " regulation in appendix C in YY/T0148-2006, the vapor permeation of every 24h is no less than 500g/ (m224h).
5, water absorption
Test according to part 1 " water absorption test method " regulation of contact Wound dressing test method in YY/T0471.1-2004, the average magnitude being affixed on the dressing absorbing fluid in 30 minutes on wound surface is not less than 11.5g/100cm2.
Note: tested sample dressing is as the criterion with effective area, and its backed film need not be peeled off, removes thicker mould release membrance and edge adjuvant.
6, content of beary metal
Content of beary metal is tested according to 5.6.1 in GB/T14233.1-2008 " heavy metal total content method one " regulation, and content of beary metal is less than 10 μ g/g.
Test liquid preparation method in content of beary metal: sample thief is 1:30 by example weight (g) and water (ml) ratio, under 37 DEG C ± 1 DEG C condition, lixiviate 24h, by sample and fluid separation applications (filtration), be chilled to room temperature, as test liquid.Get consubstantiality hydrops and be placed in glass container, with legal system for blank liquid.
7, comfortableness
When testing according to YY/T0471.4-2004, extensibility is not more than 14Ncm-1, and permanent deformation is not more than 5%.
8, heat resistant test
Get product of the present invention, removing release paper and protecting film, be placed in 60 DEG C of calorstats and heat 0.5h, and take out and put to room temperature gel-free trickling phenomenon, hydrogel layer hands touches toughness.
9, low temperature resistant test
Get product of the present invention, removing release paper and protecting film, be placed in 0 DEG C of refrigerator and place 24h, takes out and observe hydrogel layer without icing phenomenon.
10, water preventing ability
Get product of the present invention, removing release paper and protecting film, according to YY/T0471.3-2004 contact Wound dressing test method the 3rd part: the regulation of water preventing ability is tested, and its water preventing ability meets the requirement of standard YY/T0471.3-2004 defined.
11, bacterium property is hindered
Get product of the present invention, removing release paper and protecting film, according to YY/T0471.5-2004 contact Wound dressing test method the 5th part: the regulation of resistance bacterium property is tested, under semi-humid state, there is resistance bacterium property.
12, the detection of biological property
12.1 sterility tests
Carry out according to 3 " sterility test " method regulation in GB/T14233.2-2005, product is aseptic.
12.2 cell toxicity tests
Carry out according to 8.2 " lixiviating solution test " method regulation in GB/T16886.5-2003, cytotoxicity is not more than I level.
12.3 Skin Irritation Test
Carry out according to 6.3 " animal skin irritant test " method regulation in GB/T16886.10-2005, it is 0 that test specimen and solvent control are on average scored, namely without skin wound repair.
12.4 Skin sensitization
Carry out according to 7.4 " test of delayed hypersensitivity maximal dose " method regulation in GB/T16886.10-2005, level of reaction is 0, namely without delayed hypersensitivity.
The embodiment of the present invention is compared with similar products and preparation method thereof at present from the foregoing, has the following advantages:
(1) glycerol, Polyethylene Glycol, hemostatic bacteriostatic agent, deionized water and polyvinylpyrrolidone are cross-linked, independent innovational design molecular structure, develops the Multifunctional Moisture wound dressing obtained and has excellent physical and chemical performance and good biocompatibility;
(2) the PU thin film of multifunctional water gel and waterproof and breathable is arranged in pairs or groups be made into medical wound dressing, easy-to-use, the moist environment that is closed is provided simultaneously, effectively forms the environment of antibacterial resistance bacterium, avoid wound infection;
(3) by adding hemostatic bacteriostatic agent etc., comparatively like product has better hemostatic bacteriostatic, anti-inflammatory analgesic effect;
(4) the Multifunctional Moisture wound dressing obtained by the present invention has stronger liquid-absorbent, and its Liquid Absorption rate can reach the gel-like of having gone on the market and to apply ointment or plaster more than 6 times of product, makes wound healing acceleration in moist environment, shortens wound healing time;
(5) the Multifunctional Moisture wound dressing obtained by the present invention has splendid elasticity, ductility and conformable, is specially adapted to the crooked position that joint etc. is movable, does not affect body movement;
(6) be easy to industrialization production rolling, can be applicable to the quick procedure for producing of wound dressing, substantially increase prouctiveness.
Adopt Multifunctional Moisture medical wound of the present invention dressing and preparation method thereof, its waterproof and breathable, hemostatic bacteriostatic, anti-inflammatory analgetic, extremely have use value, and it can make around wound surface and wound surface district keeps closed moist environment, without any side effects; Quality softness is flexible, good mechanical property; Have very strong liquid-absorbent, 2 times of transudates of Absorbable rod own vol, namely move back sticky after imbibition, effectively prevent the wound again of wound tissue; There is splendid ductility, good with tissue attaching property, be specially adapted to the crooked position of the activities such as joint, make wound tissue produce constant moisture and happy curative effect, significantly reduce pain; Hemostatic bacteriostatic, prevents bacterial micro-organism from invading, prevention infection, for wound surface structure provides a good reparation platform, can effectively promote wound tissue quickly-healing.Its preparation method, technique is simple, is easy to industrialization, is applicable to the quick procedure for producing of continuous industryization, can effectively reduces costs, and improves yield.
In this description, the present invention is described with reference to its specific embodiment.But, still can make various amendment and conversion obviously and not deviate from the spirit and scope of the present invention.Therefore, description is regarded in an illustrative, rather than a restrictive.
Claims (7)
1. Multifunctional Moisture medical wound dressing, it is characterized in that, comprise the polyethylene release film layer, thin polyurethane rete, medical pressure-sensing glue-line, multifunctional water gel layer, the off-style paper layer that stack gradually, and be located at the release paper tearing notch on described off-style paper layer.
2. Multifunctional Moisture medical wound according to claim 1 dressing, is characterized in that, described multifunctional water gel layer comprises the composition of following mass percent:
Glycerol 15-25%;
Polyethylene Glycol 5-15%;
Polyvinylpyrrolidone 2-8%;
Hemostatic bacteriostatic agent 5-15%;
Deionized water 40-70%.
3. Multifunctional Moisture medical wound according to claim 2 dressing, is characterized in that, described hemostatic bacteriostatic agent is water-soluble chitosan.
4. Multifunctional Moisture medical wound according to claim 1 and 2 dressing, is characterized in that, the thickness of described multifunctional water gel layer is between 0.2-0.4mm.
5. Multifunctional Moisture medical wound according to claim 2 dressing, is characterized in that, the preparation method of described multifunctional water gel layer comprises the following steps:
Step (1): be dissolved in by glycerol in distilled water and be configured to the first solution, is dissolved in polyvinylpyrrolidone in distilled water and is configured to the second solution, hemostatic bacteriostatic agent is dissolved in distilled water and is configured to the 3rd solution;
Step (2): by the first described solution, the second described solution, the 3rd described solution mixing, add Polyethylene Glycol, be placed in autoclave sterilizer heating and obtain the 4th solution;
Step (3): be painted on after in TPU membrane by the 4th described solution, adopts electron beam irradiation, obtains the rete after irradiation;
Step (4): freezingly under described rete being placed in-5 DEG C to 5 DEG C conditions be placed on 15-35 DEG C of environment, is cycled to repeat repeatedly, obtains described multifunctional water gel layer.
6. Multifunctional Moisture medical wound according to claim 2 dressing, is characterized in that, described multifunctional water gel layer comprises the composition of following mass percent:
Glycerol 18-25%;
Polyethylene Glycol 8-15%;
Polyvinylpyrrolidone 5-8%;
Hemostatic bacteriostatic agent 5-10%;
Deionized water 40-70%.
7. a preparation method for Multifunctional Moisture medical wound according to claim 1 dressing, is characterized in that, comprise the following steps:
Step (1): polyethylene release film layer, thin polyurethane rete, medical pressure-sensing glue-line are stacked gradually the PU film of laminating formation with medical pressure-sensing glue-line;
Step (2): fitted by the medical pressure-sensing glue layer of the upper surface of multifunctional water gel layer and described PU film, fits described multifunctional water gel layer lower surface and the off-style paper layer be provided with from paper mold tearing notch, obtains semi-finished product of fitting;
Step (3): described laminating semi-finished product are cut into sheet-like hydrous gel according to setting specification, obtains Multifunctional Moisture wound dressing semi-finished product;
Step (4): by sterilizing after described semi finished package, obtains described Multifunctional Moisture wound dressing.
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