CN106963973B - A kind of chitosan combine dressing and preparation method thereof - Google Patents
A kind of chitosan combine dressing and preparation method thereof Download PDFInfo
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- CN106963973B CN106963973B CN201710161013.0A CN201710161013A CN106963973B CN 106963973 B CN106963973 B CN 106963973B CN 201710161013 A CN201710161013 A CN 201710161013A CN 106963973 B CN106963973 B CN 106963973B
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- 229920001661 Chitosan Polymers 0.000 title claims abstract description 79
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000002390 adhesive tape Substances 0.000 claims abstract description 30
- 239000002250 absorbent Substances 0.000 claims abstract description 29
- 230000002745 absorbent Effects 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 238000010521 absorption reaction Methods 0.000 claims abstract description 7
- 238000009987 spinning Methods 0.000 claims description 23
- 239000000243 solution Substances 0.000 claims description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 239000000853 adhesive Substances 0.000 claims description 8
- 230000001070 adhesive effect Effects 0.000 claims description 8
- 239000000835 fiber Substances 0.000 claims description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 238000010041 electrostatic spinning Methods 0.000 claims description 6
- 239000004745 nonwoven fabric Substances 0.000 claims description 6
- 229920000728 polyester Polymers 0.000 claims description 6
- 239000008213 purified water Substances 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 239000011259 mixed solution Substances 0.000 claims description 5
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 4
- 238000000520 microinjection Methods 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 229920000742 Cotton Polymers 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 239000011159 matrix material Substances 0.000 claims description 3
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims description 3
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000004080 punching Methods 0.000 claims 2
- 210000001124 body fluid Anatomy 0.000 abstract description 4
- 239000010839 body fluid Substances 0.000 abstract description 4
- 210000000416 exudates and transudate Anatomy 0.000 abstract description 4
- 230000008961 swelling Effects 0.000 abstract description 3
- 230000002087 whitening effect Effects 0.000 abstract description 3
- 206010052428 Wound Diseases 0.000 description 17
- 208000027418 Wounds and injury Diseases 0.000 description 17
- 230000033228 biological regulation Effects 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- 230000023597 hemostasis Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 230000035699 permeability Effects 0.000 description 3
- 102000009123 Fibrin Human genes 0.000 description 2
- 108010073385 Fibrin Proteins 0.000 description 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 229950003499 fibrin Drugs 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- 229920002101 Chitin Polymers 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 239000003519 biomedical and dental material Substances 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 230000007541 cellular toxicity Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 231100000263 cytotoxicity test Toxicity 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 238000005213 imbibition Methods 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
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- 230000004048 modification Effects 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000036560 skin regeneration Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
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- 238000003786 synthesis reaction Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
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Classifications
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
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- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0203—Adhesive bandages or dressings with fluid retention members
- A61F13/0206—Adhesive bandages or dressings with fluid retention members with absorbent fibrous layers, e.g. woven or non-woven absorbent pads or island dressings
- A61F13/0209—Adhesive bandages or dressings with fluid retention members with absorbent fibrous layers, e.g. woven or non-woven absorbent pads or island dressings comprising superabsorbent material
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- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer
- A61F13/0253—Adhesive bandages or dressings characterised by the skin-adhering layer characterized by the adhesive material
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- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
- A61F13/0289—Apparatus or processes for manufacturing adhesive dressings or bandages manufacturing of adhesive dressings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/05—Bandages or dressings; Absorbent pads specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
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- A—HUMAN NECESSITIES
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
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- A61L2400/00—Materials characterised by their function or physical properties
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Abstract
The present invention discloses a kind of chitosan combine dressing and preparation method thereof.The combine dressing, bed course, medical absorbent bed course, waterproof layer, medical adhesive tape adhered layer are applied including chitosan, waterproof layer is covered on medical adhesive tape adhered layer, and medical absorbent bed course is located at chitosan and applies between bed course and waterproof layer, and chitosan applies bed course and is equipped with air hole.It is identical with waterproof layer shape area that chitosan applies bed course, medical absorbent bed course, applies on bed course in chitosan and is covered with one layer of separate paper, area is consistent with medical adhesive tape adhered layer.Air hole and medical absorbent bed course on chitosan dressing layer can guarantee the high-permeability of moisture and air, and wound is avoided to occur whitening and swelling phenomenon.The medical absorbent bed course water suction mat structure strong using water absorbing properties makes tissue exudates pass through air hole and is absorbed by water absorption pad, reach efficient absorbency.Waterproof layer can prevent from making the position of dressing mulching fixed and not easily to fall off well on excessive body fluid pervious to medical adhesive tape.
Description
Technical field
The invention patent relates to a kind of medical wound dressings, and in particular to a kind of chitosan combine dressing and its preparation side
Method.
Background technique
With the development of society, clinical and requirement of the treatment of war wound to local trauma hemostasis is higher and higher, biological dressing with
Traditional dressing is compared with the dressing that compatibility is good, toxic side effect is small, antigenicity is low, has certain water penetration, can reduce the surface of a wound
Number improves the advantages that wound healing quality.Bio-medical material is considered one of most effective material of partial trauma hemostasis.Shell
Glycan is the natural polymer of de-acetyl chitin from a wealth of sources, itself there is good biocompatibility and hemostasis to make
With, the synthesis of the formation of fibrin element, the hyperplasia of phoirocyte and collagen can be prevented, and have it is anti-inflammatory, antibacterial,
Promote wound repair, reduction scar proliferation etc. biological, and anastalsis can be played through a variety of ways, for large area
Burn and scald also has the protection surface of a wound, absorbs wound exudate, and anti-inflammation and sterilization, analgesia, promotes wound healing and skin regeneration to make at hemostasis
With.The existing most structure of chitosan dressing is single, is generally made of chitosan layer, medical adhesive tape, after chitosan dressing imbibition
It needs to be fixed or penetrated on medical adhesive tape again with bandage, and easily sticks together with the surface of a wound, cause surface of a wound secondary damage.
Summary of the invention
In order to overcome the disadvantages and deficiencies of the prior art, the primary purpose of the present invention is that provide a kind of chitosan it is compound apply
Material.The combine dressing prepares chitosan using method of electrostatic spinning and applies bed course, and applies in chitosan and air hole is arranged on bed course, shell
Glycan, which applies, increases by one layer of medical absorbent bed course and waterproof layer between bed course and medical adhesive tape, medical absorbent bed course can increase liquid suction
Receipts amount, waterproof layer prevent on excessive body fluid pervious to medical adhesive tape, solve existing chitosan dressing gas permeability, absorbency is not
The problems such as sufficient.
Another object of the present invention is to provide the preparation methods of above-mentioned chitosan combine dressing.
The purpose of the invention is achieved by the following technical solution:
A kind of chitosan combine dressing, including chitosan apply bed course, medical absorbent bed course, waterproof layer, medical adhesive tape and paste
Layer, waterproof layer are covered on medical adhesive tape adhered layer, and medical absorbent bed course is located at chitosan and applies between bed course and waterproof layer, and shell is poly-
The deposited bed course of sugar, medical absorbent bed course are identical with waterproof layer shape area, apply on bed course in chitosan and are covered with one layer of separate paper, face
Product is consistent with medical adhesive tape adhered layer.
The area that the chitosan applies bed course is less than medical adhesive tape adhered layer.
The chitosan applies bed course and is prepared by method of electrostatic spinning, and chitosan applies bed course and is equipped with air hole, can increase
Add the permeability of dressing, shape is ellipse, and unique elliptic design can be relieved skin irritatin；
The size of the air hole is 0.01mm2~1000mm2；
The medical absorbent bed course is cotton water absorption layer, increases the absorbent of dressing；
The waterproof layer is polyester non-woven fabric, prevents Liquid Penetrant to the adhesive tape back side；
The matrix of the medical adhesive tape adhered layer is polyester non-woven fabric, and adhesive is lower to human skin irritation
Propylene adhesive；
The separate paper is release paper.
A kind of preparation method of chitosan combine dressing, comprising the following steps:
Step A: being in the solution of solvent, as chitosan by the mixed solution that chitosan is dissolved in purified water and polyhydroxy-alcohol
Spinning solution stands 20~28h, obtains spinning solution, spare；
Step B: in room temperature, humidity is that spinning solution is carried out electrostatic spinning, adjusts micro-injection under 40~45% environment
The rate of pump is 0.1~0.15mL/h, and the voltage for adjusting high pressure generator is 12~18KV, adjusts the reception distance for receiving roller
For 12~16cm, by controlling and receiving moving horizontally and rotating for roller with power device, the horizontal movement velocity of roller is received
For 0.001~0.003mm/s, when spinning, receives drum rotation speed and is set as 1000~5000r/s, and shell is collected on roller
Glycan spinning fibre；
Step C: it is 1.0~5.0%CaCl that chitosan spinning fibre, which is dipped in concentration,2Ethanol solution in be crosslinked,
It after crosslinking 0.5~3 hour, is rinsed 2~3 times with dehydrated alcohol, is dried to obtain chitosan at room temperature and applies bed course；
Step D: chitosan applies bed course punching；
Step E: chitosan applies bed course and medical absorbent bed course, waterproof layer are compound；
Step F: material of the step E after compound is placed in dressing manufacturing machine with medical adhesive tape adhered layer, separate paper, speed
Degree is 5~20/min；
Step G: the pack of chitosan combine dressing, mounted box, vanning, irradiation sterilization.
In step A, the mass percentage of the chitosan is 3~8%, polyhydroxy-alcohol be glycerine, propylene glycol or
One of ethylene glycol is a variety of, and the mass percent of purified water and polyhydroxy-alcohol is (1~3): 1, further preferred purified water
Mass percent with glycerine is 2:1.
In step B, the temperature of the room temperature is 25 DEG C.Jet diameters in the micro-injection pump are 0.1~1 μ
m。
In step C, the CaCl2The concentration of ethanol solution be preferably 3.0%；The time of the crosslinking is preferably
1 hour.
The present invention compared with the existing technology, have following advantages and effects
(1) component of combine dressing is using harmless to the human body, the biological material with excellent compatibility and safety
Material.
(2) chitosan combine dressing of the invention has good easily at gel-type and biocompatibility, can cover wound
Face prevents particulates emission or other harmful substances matter contaminated wound.
(3) combine dressing can make platelet adhesion reaction, form scab, and can promote the generation of fibrin ferment, promote wound certainly
Body blood coagulation；Combine dressing also has high-absorbable, can quickly and effectively absorb blood, to wound generate certain pressure, play by
Anastalsis is pressed, while keeping the moist environment of wound.
(4) air hole on chitosan dressing layer and medical absorbent bed course can guarantee the high-permeability of moisture and air, keep away
Exempt from wound to occur whitening and swelling phenomenon.The medical absorbent bed course water suction mat structure strong using water absorbing properties, makes tissue exudates
It is absorbed across air hole by water absorption pad, reaches efficient absorbency.Waterproof layer can prevent excessive body fluid pervious to medical adhesive
It takes, keeps the position of dressing mulching fixed and not easily to fall off well.
Detailed description of the invention
Fig. 1 is the structure chart of chitosan combine dressing described in the embodiment of the present invention；Wherein, 1: separate paper；2: chitosan
Apply bed course；3: medical absorbent bed course；4: waterproof layer；5: medical adhesive tape adhered layer；A: air hole.
Specific embodiment
Present invention will now be described in further detail with reference to the embodiments and the accompanying drawings, but embodiments of the present invention are unlimited
In this.
Embodiment 1
As shown in Figure 1, a kind of chitosan combine dressing, including chitosan apply bed course 2, medical absorbent bed course 3, waterproof layer 4,
Medical adhesive tape adhered layer 5, waterproof layer 4 are covered on medical adhesive tape adhered layer 5, and medical absorbent bed course 3 is located at chitosan and applies bed course 2
Between waterproof layer 4, it is identical with 4 shape area of waterproof layer that chitosan applies bed course 2, medical absorbent bed course 3, applies bed course in chitosan
One layer of separate paper 1 is covered on 2, area is consistent with medical adhesive tape adhered layer 5.
The area that the chitosan applies bed course 2 is less than medical adhesive tape adhered layer 5.
The chitosan applies bed course 2 and is equipped with air hole a, can increase the permeability of dressing, and shape is ellipse, solely
Special elliptic design, can be relieved skin irritatin；
The size of the air hole a is 0.01mm2~1000mm2；
The medical absorbent bed course 3 is cotton water absorption layer, increases the absorbent of dressing；
The waterproof layer 4 is polyester non-woven fabric, prevents Liquid Penetrant to the adhesive tape back side；
The matrix of the medical adhesive tape adhered layer is polyester non-woven fabric, and adhesive is lower to human skin irritation
Propylene adhesive；
The separate paper 1 is release paper.
Air hole a and medical absorbent bed course 3 on chitosan dressing layer 2 can guarantee the high-permeability of moisture and air, keep away
Exempt from wound to occur whitening and swelling phenomenon.The water suction mat structure strong using water absorbing properties of medical absorbent bed course 3, makes tissue exudates
It is absorbed across air hole by water absorption pad, reaches efficient absorbency.Waterproof layer 4 can prevent excessive body fluid pervious to medical adhesive
It takes, keeps the position of dressing mulching fixed and not easily to fall off well.
In use, need to only tear separate paper 1, chitosan combine dressing is then attached to wound surface.
Embodiment 2
Step A: chitosan is configured to the mixed solution that mass percentage is 3%, solvent is purified water and glycerine
Mass percent be 1:1 mixed solution, stir evenly, stand 28h, obtain spinning solution, it is spare；
Step B: being 25 DEG C in temperature, and humidity is that spinning solution is carried out electrostatic spinning, adjusts micro note under 45% environment
The rate for penetrating pump is 0.1mL/h, and the voltage for adjusting high pressure generator is 18KV, and adjusting and receiving the reception distance of roller is 12cm,
By controlling and receiving moving horizontally and rotating for roller with power device, the horizontal movement velocity for receiving roller is 0.001mm/s,
Drum rotation speed is received when spinning and is set as 1000r/s, and chitosan spinning fibre is collected on roller；
Step C: it is 1.0%CaCl that chitosan spinning fibre, which is dipped in concentration,2Ethanol solution in be crosslinked, be crosslinked
It after 0.5 hour, is rinsed 3 times with dehydrated alcohol, is dried to obtain chitosan at room temperature and applies bed course；
Step D: chitosan applies bed course punching；
Step E: chitosan applies bed course and medical absorbent cotton layer, waterproof layer are compound；
Step F: material of the step E after compound is placed in dressing manufacturing machine with medical adhesive tape adhered layer, separate paper, speed
Degree is 5~20/min；
Step G: the pack of chitosan combine dressing, mounted box, vanning, irradiation sterilization.
Embodiment 3
Step A: chitosan is configured to the mixed solution that mass percentage is 6%, solvent is purified water and glycerine
Mass percent be 2:1 mixed solution, stir evenly, stand 28h, obtain spinning solution, it is spare；
Step B: being 25 DEG C in temperature, and humidity is that spinning solution is carried out electrostatic spinning, adjusts micro note under 45% environment
The rate for penetrating pump is 0.1mL/h, and the voltage for adjusting high pressure generator is 15KV, and adjusting and receiving the reception distance of roller is 15cm,
By controlling and receiving moving horizontally and rotating for roller with power device, the horizontal movement velocity for receiving roller is 0.002mm/s,
Drum rotation speed is received when spinning and is set as 2500r/s, and chitosan spinning fibre is collected on roller；
Step C: it is 3.0%CaCl that chitosan spinning fibre, which is dipped in concentration,2Ethanol solution in be crosslinked, crosslinking 1
It after hour, is rinsed 3 times with dehydrated alcohol, is dried to obtain chitosan at room temperature and applies bed course；
Step D: chitosan applies bed course punching；
Step E: chitosan applies bed course and medical absorbent cotton layer, waterproof layer are compound；
Step F: material of the step E after compound is placed in dressing manufacturing machine with medical adhesive tape adhered layer, separate paper, speed
Degree is 5~20/min；
Step G: the pack of chitosan combine dressing, mounted box, vanning, irradiation sterilization.
Embodiment 4
Step A: chitosan is configured to the solution that mass percentage is 8%, solvent is the matter of purified water and glycerine
The mixed solution that percentage is 3:1 is measured, is stirred evenly, 28h is stood, obtains spinning solution, it is spare；
Step B: being 25 DEG C in temperature, and humidity is that spinning solution is carried out electrostatic spinning, adjusts micro note under 45% environment
The rate for penetrating pump is 0.15mL/h, and the voltage for adjusting high pressure generator is 12KV, and adjusting and receiving the reception distance of roller is 16cm,
By controlling and receiving moving horizontally and rotating for roller with power device, the horizontal movement velocity for receiving roller is 0.003mm/s,
Drum rotation speed is received when spinning and is set as 5000r/s, and chitosan spinning fibre is collected on roller；
Step C: it is 5.0%CaCl that chitosan spinning fibre, which is dipped in concentration,2Ethanol solution in be crosslinked, crosslinking 3
It after hour, is rinsed 3 times with dehydrated alcohol, is dried to obtain chitosan at room temperature and applies bed course；
Step D: chitosan applies bed course punching；
Step E: chitosan applies bed course and medical absorbent cotton layer, waterproof layer are compound；
Step F: material of the step E after compound is placed in dressing manufacturing machine with medical adhesive tape adhered layer, separate paper, speed
Degree is 5~20/min；
Step G: the pack of chitosan combine dressing, mounted box, vanning, irradiation sterilization.
Effect example
The product of above-described embodiment 2 meets fiber-like chitosan dressing properties of product in provincial standard and provides:
It takes dressing sample to be cut into the bar samples of 1cm × 5cm, adds and remove other than water absorption by surface area of sample (cm2) with
The ratio of water (mL) is the volume of water of 1:2, after capping, extracts for 24 hours at 37 DEG C ± 1 DEG C, sample is separated with liquid, is cooled to room
Temperature, as test liquid.
1, pH value
According to carrying out under the regulation of the 5.4.1 in GB/T 14233.1-2008,1 the results are shown in Table.
2, content of beary metal
The total metals of dressing are measured according to the regulation of the 5.6.1 in GB/T 14233.1-2008, the results are shown in Table
1。
3, liquid absorption amount
It is carried out according to method as defined in 3.2 in YY/T 0471.1-2004, the results are shown in Table 1.
4, moisture-vapor transmission
It is carried out according to 3.2 regulation in YY/T 0471.2-2004, the results are shown in Table 1.
5, the peel strength of medical adhesive tape adhered layer
It is carried out according to the regulation B.3 in YY/T 0148-2006 Appendix B, the results are shown in Table 1.
6, medical adhesive tape adhered layer holds viscosity
It is carried out according to the regulation B.2 in YY/T 0148-2006 Appendix B, the results are shown in Table 1.
7, biocompatibility test
7.1 cell toxicity test
It is carried out according to 8.2 regulation in GB/T 16886.5-2003, the results are shown in Table 1.
The test of 7.2 delayed allergies
It is carried out according to the regulation of the 7th chapter in GB/T 16886.10-2005, the results are shown in Table 1.
The test of 7.3 intradermal reactions
It is carried out according to the regulation of GB/T 16886.10-2005 Appendix B .2, the results are shown in Table 1.
8, sterile
Sterility test is carried out according to the regulation of the 3rd chapter in GB/T 14233.2-2005, the results are shown in Table 1.
1 properties of product test result of table
Bibliography
GB/T 14233.1-2008 medical infusion, blood transfusion, instrument used for injection method of inspection part 1: chemical analysis；
YY/T 0471.1-2004 contact surface Wound dressing test method part 1: liquid-absorbent；
YY/T 0471.2-2004 contact Wound dressing test method part 2: ventilative film dressing moisture-vapor transmission；
YY/T 0148-2006 medical adhesive tape General Requirement；
The 5th part of GB/T 16886.5-2003 BiologicalEvaluationofMedicalDevice: vitro cytotoxicity test；
The 10th part of GB/T 16886.10-2005 BiologicalEvaluationofMedicalDevice: stimulation is tried with delayed allergy
It tests；
GB/T 14233.2-2005 medical infusion, blood transfusion, instrument used for injection method of inspection part 2: biological test side
Method.
Above-described embodiment 3,4 resulting products do being compared for identical test process with embodiment 2, can get with
The approximate properties of product test result of embodiment 2, will not repeat them here.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (10)
1. a kind of chitosan combine dressing, it is characterised in that: apply bed course, medical absorbent bed course, waterproof layer, medical including chitosan
Tape-stripping layer, waterproof layer are covered on medical adhesive tape adhered layer, and medical absorbent bed course is located at chitosan and applies bed course and waterproof layer
Between；Chitosan applies bed course and is equipped with air hole；The chitosan applies bed course, medical absorbent bed course and waterproof layer shape area
It is identical；
The preparation method of the chitosan combine dressing, comprising the following steps:
Step A: being in the solution of solvent, as chitosan spinning by the mixed solution that chitosan is dissolved in purified water and polyhydroxy-alcohol
Stoste stands 20~28h, obtains spinning solution, spare；
Step B: in room temperature, humidity is that spinning solution is carried out electrostatic spinning, adjusts micro-injection pump under 40~45% environment
Rate is 0.1~0.15mL/h, and the voltage for adjusting high pressure generator is 12~18KV, and adjusting and receiving the reception distance of roller is 12
~16cm, by controlling and receiving moving horizontally and rotating for roller with power device, the horizontal movement velocity for receiving roller is
0.001~0.003mm/s receives drum rotation speed when spinning and is set as 1000~5000r/s, it is poly- that shell is collected on roller
Sugared spinning fibre；
Step C: it is 1.0~5.0%CaCl that chitosan spinning fibre, which is dipped in concentration,2Ethanol solution in be crosslinked, be crosslinked
It after 0.5~3 hour, is rinsed 2~3 times with dehydrated alcohol, is dried to obtain chitosan at room temperature and applies bed course；
Step D: chitosan applies bed course punching；
Step E: chitosan applies bed course and medical absorbent bed course, waterproof layer are compound；
Step F: material of the step E after compound is placed in dressing manufacturing machine with medical adhesive tape adhered layer, separate paper, speed is
5~20/min；
Step G: the pack of chitosan combine dressing, mounted box, vanning, irradiation sterilization；
In step A, the polyhydroxy-alcohol is one of glycerine, propylene glycol or ethylene glycol or a variety of；Purified water and polyhydroxy
The mass percent of base alcohol is (1~3): 1.
2. chitosan combine dressing according to claim 1, it is characterised in that:
It is applied on bed course in chitosan and is covered with one layer of separate paper, area is consistent with medical adhesive tape adhered layer.
3. chitosan combine dressing according to claim 1 or 2, it is characterised in that:
The area that the chitosan applies bed course is less than medical adhesive tape adhered layer.
4. chitosan combine dressing according to claim 1, it is characterised in that:
The size of the air hole is 0.01mm2~1000mm2。
5. chitosan combine dressing according to claim 1 or 2, it is characterised in that:
The medical absorbent bed course is cotton water absorption layer；
The waterproof layer is polyester non-woven fabric；
The matrix of the medical adhesive tape adhered layer is polyester non-woven fabric, and adhesive is propylene adhesive.
6. chitosan combine dressing according to claim 2, it is characterised in that:
The separate paper is release paper.
7. the preparation method of the described in any item chitosan combine dressings of claim 1~6, it is characterised in that including following step
It is rapid:
Step A: being in the solution of solvent, as chitosan spinning by the mixed solution that chitosan is dissolved in purified water and polyhydroxy-alcohol
Stoste stands 20~28h, obtains spinning solution, spare；
Step B: in room temperature, humidity is that spinning solution is carried out electrostatic spinning, adjusts micro-injection pump under 40~45% environment
Rate is 0.1~0.15mL/h, and the voltage for adjusting high pressure generator is 12~18KV, and adjusting and receiving the reception distance of roller is 12
~16cm, by controlling and receiving moving horizontally and rotating for roller with power device, the horizontal movement velocity for receiving roller is
0.001~0.003mm/s receives drum rotation speed when spinning and is set as 1000~5000r/s, it is poly- that shell is collected on roller
Sugared spinning fibre；
Step C: it is 1.0~5.0%CaCl that chitosan spinning fibre, which is dipped in concentration,2Ethanol solution in be crosslinked, be crosslinked
It after 0.5~3 hour, is rinsed 2~3 times with dehydrated alcohol, is dried to obtain chitosan at room temperature and applies bed course；
Step D: chitosan applies bed course punching；
Step E: chitosan applies bed course and medical absorbent bed course, waterproof layer are compound；
Step F: material of the step E after compound is placed in dressing manufacturing machine with medical adhesive tape adhered layer, separate paper, speed is
5~20/min；
Step G: the pack of chitosan combine dressing, mounted box, vanning, irradiation sterilization.
8. the preparation method of chitosan combine dressing according to claim 7, it is characterised in that:
In step A, the mass percentage of the chitosan is 3~8%.
9. the preparation method of chitosan combine dressing according to claim 7, it is characterised in that:
In step A, the polyhydroxy-alcohol is one of glycerine, propylene glycol or ethylene glycol or a variety of；Purified water and polyhydroxy
The mass percent of base alcohol is (1~3): 1.
10. the preparation method of chitosan combine dressing according to claim 7, it is characterised in that:
In step B, the jet diameters in the micro-injection pump are 0.1~1 μm.
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| CN108403296B (en) * | 2018-02-11 | 2020-12-18 | 郑州大学 | Double-sided opposite-nature adhesive bandage based on electrostatic spinning process and manufacturing method thereof |
| CN112891197A (en) * | 2019-12-04 | 2021-06-04 | 亳州市艾可舒医疗科技有限公司 | Moxibustion device with chitosan fiber cotton filter layer |
| CN113616421A (en) * | 2021-09-09 | 2021-11-09 | 陈国军 | Application for preventing incontinent dermatitis |
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| CN201414876Y (en) * | 2009-05-14 | 2010-03-03 | 武汉华纳联合药业有限公司 | Compound chitosan dressing |
| RU135921U1 (en) * | 2013-04-29 | 2013-12-27 | Общество с ограниченной ответственностью "Инмед" | HEMOSTATIC MEDICAL PRODUCT |
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| CN2894708Y (en) * | 2006-03-31 | 2007-05-02 | 刘维峰 | Medical bioactive dressing |
| CN102425039A (en) * | 2011-09-26 | 2012-04-25 | 常州绿之源高分子材料有限公司 | Method for preparing water-soluble chitosan fibrous membrane |
| US9101508B2 (en) * | 2011-12-07 | 2015-08-11 | Esmaeil Mirzaei | Electro spun nanofibrous wound dressing and a method of synthesizing the same |
| CN106176045B (en) * | 2016-08-31 | 2017-07-14 | 广州润虹医药科技有限公司 | A kind of alginate dressing prevented adhesion and preparation method thereof |
| CN106361498A (en) * | 2016-10-24 | 2017-02-01 | 苏州维度丝绸有限公司 | Adjustable silk band-aid |
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| CN201414876Y (en) * | 2009-05-14 | 2010-03-03 | 武汉华纳联合药业有限公司 | Compound chitosan dressing |
| RU135921U1 (en) * | 2013-04-29 | 2013-12-27 | Общество с ограниченной ответственностью "Инмед" | HEMOSTATIC MEDICAL PRODUCT |
| CN104225668A (en) * | 2014-08-26 | 2014-12-24 | 南通大学 | Staged acting antibacterial hydrogel dressing and preparation method thereof |
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Denomination of invention: A chitosan composite dressing and its preparation method Granted publication date: 20190129 Pledgee: Bank of China Limited Guangzhou Development Zone Branch Pledgor: GUANGZHOU RAINHOME PHARM&TECH Co.,Ltd. Registration number: Y2024980007361 |
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