CN112494211A - Silica gel dressing, multifunctional silica gel negative pressure drainage device and preparation method thereof - Google Patents
Silica gel dressing, multifunctional silica gel negative pressure drainage device and preparation method thereof Download PDFInfo
- Publication number
- CN112494211A CN112494211A CN202011355931.5A CN202011355931A CN112494211A CN 112494211 A CN112494211 A CN 112494211A CN 202011355931 A CN202011355931 A CN 202011355931A CN 112494211 A CN112494211 A CN 112494211A
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- CN
- China
- Prior art keywords
- layer
- silica gel
- dressing
- adhesive layer
- sensitive adhesive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 title claims abstract description 56
- 239000000741 silica gel Substances 0.000 title claims abstract description 56
- 229910002027 silica gel Inorganic materials 0.000 title claims abstract description 56
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 239000010410 layer Substances 0.000 claims abstract description 112
- 239000012790 adhesive layer Substances 0.000 claims abstract description 52
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims abstract description 49
- 239000003292 glue Substances 0.000 claims abstract description 34
- 239000004814 polyurethane Substances 0.000 claims abstract description 18
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000003908 antipruritic agent Substances 0.000 claims abstract description 16
- 239000000419 plant extract Substances 0.000 claims abstract description 16
- 230000007246 mechanism Effects 0.000 claims abstract description 7
- 239000012528 membrane Substances 0.000 claims abstract description 5
- 229920006264 polyurethane film Polymers 0.000 claims description 45
- 238000010521 absorption reaction Methods 0.000 claims description 25
- 239000000499 gel Substances 0.000 claims description 25
- 229920001296 polysiloxane Polymers 0.000 claims description 25
- 241000723346 Cinnamomum camphora Species 0.000 claims description 20
- 239000011248 coating agent Substances 0.000 claims description 15
- 238000000576 coating method Methods 0.000 claims description 15
- 238000007650 screen-printing Methods 0.000 claims description 15
- 229920002313 fluoropolymer Polymers 0.000 claims description 14
- 239000011241 protective layer Substances 0.000 claims description 13
- 230000001954 sterilising effect Effects 0.000 claims description 13
- 238000004659 sterilization and disinfection Methods 0.000 claims description 13
- 238000013329 compounding Methods 0.000 claims description 12
- JVLBPIPGETUEET-WIXLDOGYSA-O (3r,4r,4as,7ar,12bs)-3-(cyclopropylmethyl)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-3-ium-7-one Chemical group C([N@+]1(C)[C@@H]2CC=3C4=C(C(=CC=3)O)O[C@@H]3[C@]4([C@@]2(O)CCC3=O)CC1)C1CC1 JVLBPIPGETUEET-WIXLDOGYSA-O 0.000 claims description 8
- 229960002921 methylnaltrexone Drugs 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 7
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- 238000005520 cutting process Methods 0.000 claims description 6
- 238000004806 packaging method and process Methods 0.000 claims description 6
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- 238000012372 quality testing Methods 0.000 claims description 6
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- 229910001220 stainless steel Inorganic materials 0.000 claims description 5
- 239000010935 stainless steel Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 4
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims description 4
- 102000009024 Epidermal Growth Factor Human genes 0.000 claims description 3
- 101800003838 Epidermal growth factor Proteins 0.000 claims description 3
- 229940116977 epidermal growth factor Drugs 0.000 claims description 3
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 3
- 230000001681 protective effect Effects 0.000 claims description 3
- 125000000539 amino acid group Chemical group 0.000 claims description 2
- 238000011068 loading method Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 abstract description 10
- 230000035876 healing Effects 0.000 abstract description 5
- 230000008595 infiltration Effects 0.000 abstract 1
- 238000001764 infiltration Methods 0.000 abstract 1
- 229920002635 polyurethane Polymers 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 description 14
- 208000027418 Wounds and injury Diseases 0.000 description 14
- 208000003251 Pruritus Diseases 0.000 description 7
- 239000000284 extract Substances 0.000 description 7
- 230000029663 wound healing Effects 0.000 description 6
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 5
- MFYSUUPKMDJYPF-UHFFFAOYSA-N 2-[(4-methyl-2-nitrophenyl)diazenyl]-3-oxo-n-phenylbutanamide Chemical compound C=1C=CC=CC=1NC(=O)C(C(=O)C)N=NC1=CC=C(C)C=C1[N+]([O-])=O MFYSUUPKMDJYPF-UHFFFAOYSA-N 0.000 description 5
- 235000006679 Mentha X verticillata Nutrition 0.000 description 5
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- 241000219784 Sophora Species 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000011550 stock solution Substances 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 229960000846 camphor Drugs 0.000 description 3
- 229930008380 camphor Natural products 0.000 description 3
- 210000000416 exudates and transudate Anatomy 0.000 description 3
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- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
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- 239000000243 solution Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- QNRATNLHPGXHMA-XZHTYLCXSA-N (r)-(6-ethoxyquinolin-4-yl)-[(2s,4s,5r)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]methanol;hydrochloride Chemical compound Cl.C([C@H]([C@H](C1)CC)C2)CN1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OCC)C=C21 QNRATNLHPGXHMA-XZHTYLCXSA-N 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
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- 101100118545 Holotrichia diomphalia EGF-like gene Proteins 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 238000012865 aseptic processing Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
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- 238000009581 negative-pressure wound therapy Methods 0.000 description 1
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- 230000000149 penetrating effect Effects 0.000 description 1
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- 230000001737 promoting effect Effects 0.000 description 1
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Images
Classifications
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- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00987—Apparatus or processes for manufacturing non-adhesive dressings or bandages
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- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/05—Bandages or dressings; Absorbent pads specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A61L15/42—Use of materials characterised by their function or physical properties
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Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Vascular Medicine (AREA)
- Botany (AREA)
- Anesthesiology (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Manufacturing & Machinery (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a silica gel dressing, a multifunctional silica gel negative pressure drainage device and a preparation method thereof, and relates to the technical field of medical instruments. Silica gel dressing includes the dressing body, the dressing body is including the polyurethane membrane that from top to bottom sets gradually, the absorbed layer, filter layer and glue film, the double-sided adhesive layer of glue film for having the air vent, double-sided adhesive layer includes medical pressure sensitive adhesive and silica gel, the both sides of glue film are equipped with handheld limit of first handheld limit and the handheld limit of second respectively, be provided with a plurality of edges of a knife on the glue film, a plurality of edges of a knife dislocation evenly distributed, when the handheld limit of first handheld limit and second was pulled open to both sides, the edge of a knife formed the infiltration zone that has the rhombus space. The multifunctional silica gel negative pressure drainage device comprises a silica gel dressing, a drainage mechanism and a negative pressure source. The dressing body adopts the double-sided adhesive layer with good adhesion and skin-friendly property, and the appropriate amount of nano silver, plant extract, growth factor and antipruritic agent are added into the silica gel, so that the healing of the wound is remarkably accelerated.
Description
The present application is a divisional application of the chinese patent application with the patent office of china, application number CN201610743422.7, entitled "a multifunctional negative pressure drainage device of silicone gel and method for making the same" filed on 29/08/2016, the entire contents of which are incorporated by reference in the present application.
Technical Field
The invention relates to the technical field of medical instruments, in particular to a silica gel dressing, a multifunctional silica gel negative pressure drainage device and a preparation method of the multifunctional silica gel negative pressure drainage device.
Background
Negative pressure wound therapy is the application of controlled negative pressure to the wound, generated by a negative pressure pump, which applies continuous or intermittent negative pressures of different pressures to the wound through a "filter" (foam or gauze) covering the wound. The drainage tube is connected with the transparent film auxiliary material for sealing the wound, and the drainage liquid is continuously sucked into the liquid storage tank. Negative pressure therapy can remove wound exudate, necrotic tissues and bacteria, effectively relieve edema, promote angiogenesis, improve local blood circulation, increase local oxygen supply, and thus promote wound healing. Because of its definite therapeutic effect, negative pressure therapy has been widely accepted and applied in clinical practice.
The patent: drainage dressing is sealed to silica gel negative pressure (application number 201510924870.2, publication number CN105434107A) discloses a drainage dressing is sealed to silica gel negative pressure, including applying the material, be connected with the drainage structure that can get rid of the exudate under the negative pressure effect on applying the material, the dressing body is including the silica gel layer that can adhere to the human body, and the equipartition has the through-hole on the silica gel layer, sets gradually the stock solution filter layer that has storage and filtering capability and has the absorbent structure who absorbs the exudate function on the silica gel layer. This patent can prevent that the wound from bleeding, accelerate wound healing, but the silica gel layer of adhesion effect plays in this patent, this silica gel layer is carried on the PU membrane for silica gel, PU membrane coating silica gel's one side and human skin bond, the another side bonds with the stock solution filter layer, silica gel layer is better with the adhesion of skin, but another side and stock solution filter layer do not have adhesion basically, can take place the dislocation between silica gel layer and the stock solution filter layer in the use, it is poor to lead to drainage device's leakproofness, influence the drainage effect, be unfavorable for the healing of wound. In addition, the silicone gel has only basic performances of moisture retention and adhesion, and can generate symptoms such as pruritus when a wound is healed, and the silicone gel is arranged close to the wound and cannot play a role in relieving the symptoms, so that the application of the patent is limited.
Disclosure of Invention
In order to solve the defects of the prior art, the invention provides a multifunctional silica gel negative pressure drainage device and a preparation method thereof.
The technical scheme of the invention is realized as follows:
a multifunctional silicone gel negative pressure drainage device comprises: the dressing body, the drainage mechanism connected with the dressing body and the negative pressure source;
the dressing body comprises a polyurethane film, an absorption layer, a filter layer and a glue layer which are sequentially arranged from top to bottom, the glue layer is a double-sided glue layer with vent holes, one side of the double-sided glue layer, which is connected with the filter layer, is a medical pressure-sensitive adhesive, and the other side is silica gel which can be connected with a human body; the lower surface of the polyurethane film is also provided with medical pressure-sensitive adhesive, the outer edge of the polyurethane film is adhered to the outer edge of the adhesive layer, so that the absorption layer and the filter layer are coated between the polyurethane film and the adhesive layer (in order to improve the filtering effect and prevent small-volume necrotic tissues from entering the absorption layer 2, a biological filter membrane is also arranged between the absorption layer 2 and the filter layer 3);
the two sides of the adhesive layer are respectively provided with a first handheld side and a second handheld side, the adhesive layer is provided with a plurality of knife edges, the knife edges are staggered and evenly distributed, and when the first handheld side and the second handheld side are pulled open to the two sides, the knife edges form a penetration area with a rhombic gap.
Preferably, the silicone gel of 100 parts by weight further comprises the following components in parts by weight: 0.01-0.05 parts of nano silver, 0.2-0.4 parts of plant extract, 0.5-4 parts of growth factor and 0.3-0.5 parts of antipruritic.
According to the invention, the double-sided adhesive layer with good adhesion and good skin-friendly performance is adopted, the first handheld edge 42 and the second handheld edge 43 are respectively arranged on the two sides of the adhesive layer 4, and under the action of external force, the knife edge on the adhesive layer 4 automatically cracks to form the penetrating area 44 with the diamond-shaped gap, so that the adaptability of the adhesive layer 4 and a human body is improved, the tight feeling is not generated, the drawing-out and the leading-out of seepage are facilitated, and the use is convenient. The side of the adhesive layer 4 provided with the silica gel is bonded with the human body, and the side provided with the medical pressure-sensitive adhesive is bonded with the filter layer 3, so that the tightness and the drainage efficiency of the silica gel negative pressure drainage device are improved, and the faster healing of the wound is facilitated. In addition, growth factors capable of promoting skin growth, plant extracts with the functions of sterilization, inflammation diminishing and itching relieving and special antipruritic are added, discomfort caused by wound healing is effectively relieved, and wound healing is remarkably accelerated.
Preferably, the nano silver has a particle size range of 25-50nm, and the plant extract is prepared from the following raw materials in a weight ratio of 1: 2: 3, the mixture extract of the lightyellow sophora root, the mint, the camphor tree trunk or the camphor tree root, the camphor tree is the camphor tree with the age of more than 50 years, and the antipruritic agent is methylnaltrexone.
Epidermal Growth Factor (EGF) is the earliest growth factor found and plays an important role in regulating cell growth, proliferation and differentiation. Epidermal growth factor is a small peptide consisting of 53 amino acid residues, a member of the EGF-like large family.
The nano silver has super-strong permeability and bactericidal property, and can promote wound healing, promote the repair and regeneration of damaged cells, remove the necrotic tissue and promote granulation, resist bacteria and diminish inflammation, improve the microcirculation of tissues around the wound, effectively activate and promote the growth of the tissue cells, accelerate the healing of the wound and reduce the generation of scars.
Radix Sophorae Flavescentis has antibacterial and anti-inflammatory effects; the mint extract contains menthol which can induce the cool feeling same as low temperature, cool the skin and relieve the induced skin itch; the camphor tree leaf extract contains camphor, the camphor has the functions of killing insects, relieving itching, reducing swelling, relieving pain and mild anesthesia, and can be used for treating skin itch, the camphor tree leaf extract mainly contains pure dextro camphor, and the trunks or roots of camphor trees with the age of more than 50 years contain more dextro camphor; the methylnaltrexone has the function of treating skin itch. The common action of the radix sophorae flavescentis, the menthol, the camphor and the methylnaltrexone can treat both symptoms and root causes of skin itch generated in wound healing, and the addition proportion has a very good treatment effect and does not damage wounds.
Preferably, the upper surface of the polyurethane film is provided with a PE protective film; the lower surface of the adhesive layer is provided with a PE or PET fluoroplastic release film, the PE or PET fluoroplastic release film comprises two PE or PET fluoroplastic release films covering the lower surface of the adhesive layer, and adjacent sides of the two PE or PET fluoroplastic release films are mutually overlapped; the adhesive layer also comprises a PU film for loading medical pressure-sensitive adhesive and silica gel; the area of the absorption layer is not less than that of the filter layer, and the absorption layer completely covers the filter layer.
The invention also provides a preparation method of the multifunctional silica gel negative pressure drainage device, and the production process of the dressing body comprises the following steps:
step one, preparing an adhesive layer:
arranging the medical pressure-sensitive adhesive on the PU film carrier in a screen printing or scraper coating mode, and covering a protective layer on the medical pressure-sensitive adhesive;
coating the mixed silica gel on the other side of the PU film carrier, curing to obtain a silica gel layer, and then covering the PE or PET fluoroplastic release film subjected to disinfection and sterilization on the silica gel layer;
performing transparent cutting on the product obtained in the last step in a staggered mode to form a plurality of rows and a plurality of columns of knife edges, wherein only part of the positions of the knife edges in the front column and the positions of the knife edges in the back column are positioned on the same level in the two adjacent columns;
secondly, preparing a polyurethane film provided with the medical pressure-sensitive adhesive:
arranging the medical pressure-sensitive adhesive on the polyurethane film in a screen printing or scraper coating mode;
thirdly, compounding:
tearing off the protective layer, and sequentially compounding the filter layer and the absorption layer between the side of the adhesive layer provided with the medical pressure-sensitive adhesive and the side of the polyurethane film provided with the medical pressure-sensitive adhesive;
step four, subsequent processing: comprises sterilizing, blanking, screening, quality testing, and packaging.
The production needs to be carried out in a clean environment of more than 10 ten thousand grades, and the PU film carrier, the protective layer and the PE or PET fluoroplastic release film can be used after being subjected to aseptic processing.
Preferably, a 100-150 mesh/inch stainless steel screen or a PET screen is used in the screen printing.
Preferably, the thickness of the layer of silicone gel is 0.08-0.25 mm.
More preferably, the thickness of the silicone gel layer is 0.15 to 0.2 mm.
Compared with the prior art, the double-sided adhesive layer with good adhesion and skin-friendly performance is adopted, and the appropriate amount of nano silver, plant extract, growth factor and antipruritic agent are added into the silica gel, so that the healing of the wound is accelerated under the combined action of the nano silver, the plant extract, the growth factor and the antipruritic agent.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
FIG. 1 is a schematic cross-sectional view of a dressing body;
fig. 2 is a top view of the adhesive layer of fig. 1.
In the figure: 1. a polyurethane film; 11. PE protective film; 2. an absorbing layer; 3. a filter layer; 4. a glue layer; 41. PE or PET fluoroplastic release film; 42. a first handheld edge; 43. a second handheld edge; 44. a permeable zone.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A multifunctional silicone gel negative pressure drainage device comprises: the dressing body, a drainage mechanism connected with the dressing body and a negative pressure source 9;
the dressing body comprises a polyurethane film 1, an absorption layer 2, a filter layer 3 and a glue layer 4 which are sequentially arranged from top to bottom, wherein the glue layer 4 is a double-sided glue layer with a vent hole, one side of the double-sided glue layer, which is connected with the filter layer 3, is medical pressure-sensitive glue, and the other side is silica gel which can be connected with a human body; the lower surface of the polyurethane film 1 is also provided with medical pressure-sensitive adhesive, and the outer edge of the polyurethane film 1 is adhered to the outer edge of the adhesive layer 4, so that the absorption layer 2 and the filter layer 3 are coated between the polyurethane film 1 and the adhesive layer 4;
a first handheld edge 42 and a second handheld edge 43 are respectively arranged on two sides of the adhesive layer 4, a plurality of knife edges are arranged on the adhesive layer 4 and are uniformly distributed in a staggered manner, and when the first handheld edge 42 and the second handheld edge 43 are pulled open towards the two sides, the knife edges form a penetration area 44 with a diamond-shaped gap;
the silicone gel of 100 weight portions also comprises the following components of: 0.05 part of nano silver, 0.3 part of plant extract, 0.5 part of growth factor and 0.5 part of antipruritic.
The particle size range of the nano silver is 30nm, and the weight ratio of the plant extracts is 1: 2: 3, the mixed extract of the lightyellow sophora root, the mint, the camphor tree trunk or the camphor tree root with the age of more than 50 years, and the antipruritic agent is methylnaltrexone.
The production process of the dressing body comprises the following steps:
step one, preparing a glue layer 4:
arranging a medical pressure-sensitive adhesive on the PU film carrier in a screen printing mode, and covering a protective layer on the medical pressure-sensitive adhesive;
coating the mixed silica gel on the other surface of the PU film carrier, curing to obtain a silica gel layer with the thickness of 0.08mm, and then covering the PET fluoroplastic release film 41 subjected to disinfection and sterilization on the silica gel layer;
performing transparent cutting on the product obtained in the last step in a staggered mode to form a plurality of rows and a plurality of columns of knife edges, wherein only part of the positions of the knife edges in the front column and the positions of the knife edges in the back column are positioned on the same level in the two adjacent columns;
step two, preparing a polyurethane film 1 provided with a medical pressure-sensitive adhesive:
arranging the medical pressure-sensitive adhesive on the polyurethane film 1 in a screen printing mode, wherein a 120-mesh/inch stainless steel screen plate or a PET screen plate is adopted in the screen printing in the first step and the second step;
thirdly, compounding:
tearing off the protective layer, and sequentially compounding the filter layer 3 and the absorption layer 2 between the surface provided with the medical pressure-sensitive adhesive in the adhesive layer 4 and the surface provided with the medical pressure-sensitive adhesive in the polyurethane film 1;
step four, subsequent processing: comprises sterilizing, blanking, screening, quality testing, and packaging.
Example 2
A multifunctional silicone gel negative pressure drainage device comprises: the dressing body, a drainage mechanism connected with the dressing body and a negative pressure source 9;
the dressing body comprises a polyurethane film 1, an absorption layer 2, a filter layer 3 and a glue layer 4 which are sequentially arranged from top to bottom, wherein the glue layer 4 is a double-sided glue layer with a vent hole, one side of the double-sided glue layer, which is connected with the filter layer 3, is medical pressure-sensitive glue, and the other side is silica gel which can be connected with a human body; the lower surface of the polyurethane film 1 is also provided with medical pressure-sensitive adhesive, and the outer edge of the polyurethane film 1 is adhered to the outer edge of the adhesive layer 4, so that the absorption layer 2 and the filter layer 3 are coated between the polyurethane film 1 and the adhesive layer 4;
a first handheld edge 42 and a second handheld edge 43 are respectively arranged on two sides of the adhesive layer 4, a plurality of knife edges are arranged on the adhesive layer 4 and are uniformly distributed in a staggered manner, and when the first handheld edge 42 and the second handheld edge 43 are pulled open towards the two sides, the knife edges form a penetration area 44 with a diamond-shaped gap;
the silicone gel of 100 weight portions also comprises the following components of: 0.03 part of nano-silver, 0.2 part of plant extract, 4 parts of growth factor and 0.4 part of antipruritic agent.
The particle size range of the nano silver is 25nm, and the weight ratio of the plant extracts is 1: 2: 3, the mixed extract of the lightyellow sophora root, the mint, the camphor tree trunk or the camphor tree root with the age of more than 50 years, and the antipruritic agent is methylnaltrexone.
The production process of the dressing body comprises the following steps:
step one, preparing a glue layer 4:
coating the medical pressure-sensitive adhesive on the PU film carrier in a manner of coating by a scraper, and covering a protective layer on the medical pressure-sensitive adhesive;
coating the mixed silica gel on the other side of the PU film carrier, curing to obtain a silica gel layer with the thickness of 0.15mm, and then covering the PE subjected to disinfection and sterilization on the silica gel layer;
performing transparent cutting on the product obtained in the last step in a staggered mode to form a plurality of rows and a plurality of columns of knife edges, wherein only part of the positions of the knife edges in the front column and the positions of the knife edges in the back column are positioned on the same level in the two adjacent columns;
step two, preparing a polyurethane film 1 provided with a medical pressure-sensitive adhesive:
coating the medical pressure-sensitive adhesive on the polyurethane film 1 in a manner of blade coating;
thirdly, compounding:
tearing off the protective layer, and sequentially compounding the filter layer 3 and the absorption layer 2 between the surface provided with the medical pressure-sensitive adhesive in the adhesive layer 4 and the surface provided with the medical pressure-sensitive adhesive in the polyurethane film 1;
step four, subsequent processing: comprises sterilizing, blanking, screening, quality testing, and packaging.
Example 3
A multifunctional silicone gel negative pressure drainage device comprises: the dressing body, a drainage mechanism connected with the dressing body and a negative pressure source 9;
the dressing body comprises a polyurethane film 1, an absorption layer 2, a filter layer 3 and a glue layer 4 which are sequentially arranged from top to bottom, wherein the glue layer 4 is a double-sided glue layer with a vent hole, one side of the double-sided glue layer, which is connected with the filter layer 3, is medical pressure-sensitive glue, and the other side is silica gel which can be connected with a human body; the lower surface of the polyurethane film 1 is also provided with medical pressure-sensitive adhesive, and the outer edge of the polyurethane film 1 is adhered to the outer edge of the adhesive layer 4, so that the absorption layer 2 and the filter layer 3 are coated between the polyurethane film 1 and the adhesive layer 4;
a first handheld edge 42 and a second handheld edge 43 are respectively arranged on two sides of the adhesive layer 4, a plurality of knife edges are arranged on the adhesive layer 4 and are uniformly distributed in a staggered manner, and when the first handheld edge 42 and the second handheld edge 43 are pulled open towards the two sides, the knife edges form a penetration area 44 with a diamond-shaped gap;
the silicone gel of 100 weight portions also comprises the following components of: 0.01 weight part of nano silver, 0.4 weight part of plant extract, 2 weight parts of growth factor and 0.3 weight part of antipruritic.
The particle size range of the nano silver is 50nm, and the weight ratio of the plant extracts is 1: 2: 3, the mixed extract of the lightyellow sophora root, the mint, the camphor tree trunk or the camphor tree root with the age of more than 50 years, and the antipruritic agent is methylnaltrexone.
The production process of the dressing body comprises the following steps:
step one, preparing a glue layer 4:
arranging a medical pressure-sensitive adhesive on the PU film carrier in a screen printing mode, and covering a protective layer on the medical pressure-sensitive adhesive;
coating the mixed silica gel on the other side of the PU film carrier, curing to obtain a silica gel layer with the thickness of 0.2mm, and then covering the PET fluoroplastic release film 41 subjected to disinfection and sterilization on the silica gel layer;
performing transparent cutting on the product obtained in the last step in a staggered mode to form a plurality of rows and a plurality of columns of knife edges, wherein only part of the positions of the knife edges in the front column and the positions of the knife edges in the back column are positioned on the same level in the two adjacent columns;
step two, preparing a polyurethane film 1 provided with a medical pressure-sensitive adhesive:
arranging the medical pressure-sensitive adhesive on the polyurethane film 1 in a screen printing mode, wherein a 150-mesh/inch stainless steel screen plate or a PET screen plate is adopted in the screen printing in the first step and the second step;
thirdly, compounding:
tearing off the protective layer, and sequentially compounding the filter layer 3 and the absorption layer 2 between the surface provided with the medical pressure-sensitive adhesive in the adhesive layer 4 and the surface provided with the medical pressure-sensitive adhesive in the polyurethane film 1;
step four, subsequent processing: comprises sterilizing, blanking, screening, quality testing, and packaging.
Example 4
A multifunctional silicone gel negative pressure drainage device comprises: the dressing body, a drainage mechanism connected with the dressing body and a negative pressure source 9;
the dressing body comprises a polyurethane film 1, an absorption layer 2, a filter layer 3 and a glue layer 4 which are sequentially arranged from top to bottom, wherein the glue layer 4 is a double-sided glue layer with a vent hole, one side of the double-sided glue layer, which is connected with the filter layer 3, is medical pressure-sensitive glue, and the other side is silica gel which can be connected with a human body; the lower surface of the polyurethane film 1 is also provided with medical pressure-sensitive adhesive, and the outer edge of the polyurethane film 1 is adhered to the outer edge of the adhesive layer 4, so that the absorption layer 2 and the filter layer 3 are coated between the polyurethane film 1 and the adhesive layer 4;
a first handheld edge 42 and a second handheld edge 43 are respectively arranged on two sides of the adhesive layer 4, a plurality of knife edges are arranged on the adhesive layer 4 and are uniformly distributed in a staggered manner, and when the first handheld edge 42 and the second handheld edge 43 are pulled open towards the two sides, the knife edges form a penetration area 44 with a diamond-shaped gap;
the silicone gel of 100 weight portions also comprises the following components of: 0.01 weight part of nano silver, 0.4 weight part of plant extract, 2 weight parts of growth factor and 0.3 weight part of antipruritic.
The particle size range of the nano silver is 50nm, and the weight ratio of the plant extracts is 1: 2: 3, the mixed extract of the lightyellow sophora root, the mint, the camphor tree trunk or the camphor tree root with the age of more than 50 years, and the antipruritic agent is methylnaltrexone.
The production process of the dressing body comprises the following steps:
step one, preparing a glue layer 4:
arranging a medical pressure-sensitive adhesive on the PU film carrier in a screen printing mode, and covering a protective layer on the medical pressure-sensitive adhesive;
coating the mixed silica gel on the other side of the PU film carrier, curing to obtain a silica gel layer with the thickness of 0.25mm, and then covering the PE subjected to disinfection and sterilization on the silica gel layer;
performing transparent cutting on the product obtained in the last step in a staggered mode to form a plurality of rows and a plurality of columns of knife edges, wherein only part of the positions of the knife edges in the front column and the positions of the knife edges in the back column are positioned on the same level in the two adjacent columns;
step two, preparing a polyurethane film 1 provided with a medical pressure-sensitive adhesive:
arranging the medical pressure-sensitive adhesive on the polyurethane film 1 in a screen printing mode, wherein 130-mesh/inch stainless steel screen plates or PET screen plates are adopted in the screen printing in the first step and the second step;
thirdly, compounding:
tearing off the protective layer, and sequentially compounding the filter layer 3 and the absorption layer 2 between the surface provided with the medical pressure-sensitive adhesive in the adhesive layer 4 and the surface provided with the medical pressure-sensitive adhesive in the polyurethane film 1;
step four, subsequent processing: comprises sterilizing, blanking, screening, quality testing, and packaging.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (8)
1. A silicone gel dressing characterized by: the medical pressure-sensitive adhesive dressing comprises a dressing body, wherein the dressing body comprises a polyurethane film (1), an absorption layer (2), a filter layer (3) and an adhesive layer (4) which are sequentially arranged from top to bottom, the adhesive layer (4) is a double-sided adhesive layer with vent holes, one side of the double-sided adhesive layer, which is connected with the filter layer (3), is medical pressure-sensitive adhesive, and the other side of the double-sided adhesive layer is silica gel which can be connected with a human body; the lower surface of the polyurethane film (1) is also provided with medical pressure-sensitive adhesive, and the outer edge of the polyurethane film (1) is adhered to the outer edge of the adhesive layer (4) so that the absorption layer (2) and the filter layer (3) are coated between the polyurethane film (1) and the adhesive layer (4); a biological filtering membrane is also arranged between the absorption layer (2) and the filtering layer (3);
a first handheld edge (42) and a second handheld edge (43) are respectively arranged on two sides of the adhesive layer (4), a plurality of knife edges are arranged on the adhesive layer (4) and are uniformly distributed in a staggered mode, and when the first handheld edge (42) and the second handheld edge (43) are pulled open towards the two sides, the knife edges form a penetration area (44) with a diamond-shaped gap;
the silicone gel of 100 parts by weight also comprises the following components in parts by weight: 0.01-0.05 parts of nano silver, 0.2-0.4 parts of plant extract, 0.5-4 parts of epidermal growth factor and 0.4-0.5 parts of antipruritic.
2. The silicone gel dressing of claim 1,
a PE protective film (11) is arranged on the upper surface of the polyurethane film (1);
the lower surface of the adhesive layer (4) is provided with a PE or PET fluoroplastic release film (41), the PE or PET fluoroplastic release film (41) comprises two PE or PET fluoroplastic release films covering the lower surface of the adhesive layer (4), and the adjacent sides of the two PE or PET fluoroplastic release films are mutually overlapped;
the adhesive layer (4) also comprises a PU film for loading the medical pressure-sensitive adhesive and the silica gel;
the area of the absorption layer (2) is not less than that of the filter layer (3), and the absorption layer (2) completely covers the filter layer (3).
3. The silicone gel dressing of claim 1, wherein the nanosilver has a particle size in the range of 25-50nm, and the plant extract is present in a weight ratio of 1: 2: 3, the camphor tree is a camphor tree with the age of more than 50 years, and the antipruritic agent is methylnaltrexone; the herba Menthae contains Mentholum.
4. The silicone gel dressing of claim 1, wherein the epidermal growth factor is a small peptide consisting of 53 amino acid residues.
5. A multifunctional negative pressure silicone gel drainage device, comprising the dressing body according to any one of claims 1 to 4, a drainage mechanism connected with the dressing body, and a negative pressure source (9).
6. The preparation method of the multifunctional silicone gel negative pressure drainage device according to claim 5, wherein the production process of the dressing body comprises the following steps:
first, a glue layer (4) is prepared:
arranging a medical pressure-sensitive adhesive on a PU film carrier in a screen printing or scraper coating mode, and covering a protective layer on the medical pressure-sensitive adhesive;
coating the mixed silica gel on the other surface of the PU film carrier and curing to obtain a silica gel layer, and then covering the PE or PET fluoroplastic release film (41) subjected to disinfection and sterilization treatment on the silica gel layer;
performing transparent cutting on the product obtained in the last step in a staggered mode to form a plurality of rows and a plurality of columns of knife edges, wherein only part of the positions of the knife edges in the front column and the positions of the knife edges in the back column are positioned on the same level in the two adjacent columns;
secondly, preparing a polyurethane film (1) provided with the medical pressure-sensitive adhesive:
arranging the medical pressure-sensitive adhesive on the polyurethane film (1) in a screen printing or scraper coating mode;
thirdly, compounding:
tearing off the protective layer, and sequentially compounding the filter layer (3) and the absorption layer (2) between the surface of the adhesive layer (4) provided with the medical pressure-sensitive adhesive and the surface of the polyurethane film (1) provided with the medical pressure-sensitive adhesive;
step four, subsequent processing: comprises sterilizing, blanking, screening, quality testing, and packaging.
7. The preparation method of the multifunctional negative pressure silicone gel drainage device as recited in claim 6, wherein a stainless steel screen plate or a PET screen plate with 100-150 meshes/inch is adopted in the screen printing.
8. The method for preparing the multifunctional negative pressure silicone gel drainage device according to claim 6, wherein the thickness of the silicone gel layer is 0.08-0.15 mm.
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| CN201610743422.7A CN106390213A (en) | 2016-08-29 | 2016-08-29 | Multifunctional silica gel negative-pressure drainage device and manufacturing method thereof |
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| US11690766B2 (en) | 2017-06-07 | 2023-07-04 | Kci Licensing, Inc. | Composite dressings for improved granulation and reduced maceration with negative-pressure treatment |
| WO2018226627A1 (en) | 2017-06-07 | 2018-12-13 | Kci Licensing, Inc. | Composite dressings for improved granulation and reduced maceration with negative-pressure treatment |
| WO2018226691A1 (en) | 2017-06-07 | 2018-12-13 | Kci Licensing, Inc. | Methods for manufacturing and assembling dual material tissue interface for negative-pressure therapy |
| AU2018281333A1 (en) * | 2017-06-07 | 2019-10-31 | 3M Innovative Properties Company | Peel and place dressing for negative-pressure therapy |
| BR112019025025A2 (en) * | 2017-06-07 | 2020-06-16 | Kci Licensing, Inc | I THINK TO TREAT A TISSUE SITE WITH NEGATIVE PRESSURE, SYSTEM TO TREAT TISSUE WITH NEGATIVE PRESSURE, METHOD FOR TREATING A WOUND WITH NEGATIVE PRESSURE, USE OF THE SAME, AND SYSTEMS, APPLIANCES AND METHODS |
| AU2018281102A1 (en) | 2017-06-07 | 2019-12-19 | 3M Innovative Properties Company | Systems, apparatuses, and methods for negative-pressure treatment with reduced tissue in-growth |
| BR112019025031A2 (en) | 2017-06-07 | 2020-08-18 | Kci Licensing, Inc | I think to treat a negative pressure tissue site and systems, devices and methods |
| WO2018226687A1 (en) | 2017-06-07 | 2018-12-13 | Kci Licensing, Inc. | Methods for manufacturing and assembling dual material tissue interface for negative-pressure therapy |
| CA3065521A1 (en) | 2017-06-07 | 2018-12-13 | Kci Licensing, Inc. | Multi-layer wound filler for extended wear time |
| WO2018226707A1 (en) | 2017-06-07 | 2018-12-13 | Kci Licensing, Inc. | Composite dressings for improved granulation reduced maceration with negative-pressure treatment |
| EP3735211B1 (en) * | 2018-01-04 | 2024-03-13 | Solventum Intellectual Properties Company | Peel and place dressing for thick exudate and instillation |
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| CN106390213A (en) | 2017-02-15 |
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