CN109731124A - A kind of nano silver composite hydrogel dressing patch and preparation method thereof - Google Patents
A kind of nano silver composite hydrogel dressing patch and preparation method thereof Download PDFInfo
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- CN109731124A CN109731124A CN201811580258.8A CN201811580258A CN109731124A CN 109731124 A CN109731124 A CN 109731124A CN 201811580258 A CN201811580258 A CN 201811580258A CN 109731124 A CN109731124 A CN 109731124A
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Abstract
The present invention relates to dressing to manufacture field, especially a kind of nano silver composite hydrogel dressing patch and preparation method thereof, including an aerogel dressing layer, in fixed one protective layer of adhesion in the top of aerogel dressing layer, the bottom edge of the aerogel dressing layer is bent downwardly, a splicing tape is respectively fixedly connected in the two opposed ends of protective layer, adhesion has a dustproof membrane respectively in aerogel dressing layer bottom, each splicing tape bottom.The structure design of the corner of its present apparatus can effectively enhance the trend that aerogel dressing layer edge is drawn close to skin, while can effectively act as the problem of preventing corner from tilting, and be effectively guaranteed safety in use.The present apparatus can bring following effect on group is grouped as: providing the aldehyde radical of schiff base reaction using oxidized sodium alginate, avoid the introducing of toxic chemical crosslinking agent；Using chitosan and sodium alginate as main material, a variety of advantages such as two kinds of material moisturizings, antibacterial, blood coagulation, degradation, water suctions are had both.
Description
Technical field
The present invention relates to dressing to manufacture field, especially a kind of nano silver composite hydrogel dressing patch and its preparation side
Method.
Background technique
With the development of medical technology, from the fifties in last century, wound wet union environmental theory is medical treatment and nursing circle
It is widely recognized as and uses.Traditional bearing hydrocolloid dressing patch has been obtained as the major product of wound wet union widely answers
With the dressing being mainly mixed and processed by the polymeric hydrogel and synthetic rubber and goo of elasticity.
Film dressing, foam dressing, bearing hydrocolloid dressing and aerogel dressing and alginate dressing at present on the market is
Gradually develop, occupies middle and high-end market, and become the inexorable trend of dressing development.Foam dressing be primarily adapted for use in it is some have it is a large amount of
The affected part of the wound of sepage, chronic wounds has the disadvantage in that diffusate will not be stablized by foam when in use and adsorbs；Without viscous
Property, need outer layer dressing to fix；It is opaque, it is unfavorable for observing wound situation；Bearing hydrocolloid dressing be primarily adapted for use in chronic ulcer,
A small amount of sepage surface of a wound such as bedsore, phlebitis, has the disadvantage in that water imbibition is poor when in use, has certain peculiar smell after absorbing sepage,
It is not suitable for the surface of a wound more than diffusate；It needs to clean when replacement；Bearing hydrocolloid dressing be primarily adapted for use in scratch, chemical lesion, burn,
The surface layers wounds such as laser therapy, pressure sore initial stage have the disadvantage in that water imbibition is poor when in use；Dressing is inviscid, needs two
Grade dressing is fixed；Alginate dressing is primarily adapted for use in the wound of a large amount of sepages, chronic wounds, there is following lack when in use
Point: forming soft gel after water suction, can remain on wound, and when replacement needs to clean.In addition, existing dressing processing when by
In the limitation of its processing technology and making material, it is caused usually to there is toxic chemical crosslinking agent during processing
It introduces, and moisturizing is breathed freely poor when use, there is also many deficiencies in terms of mechanical performance, swelling ratio, so that nursing efficacy is poor.
Summary of the invention
The present invention one of to solve above-mentioned technical problem used by technical solution be: a kind of nano silver composite hydrogel is applied
Material patch, including an aerogel dressing layer, in fixed one protective layer of adhesion in the top of aerogel dressing layer, the aerogel dressing layer
Bottom edge be bent downwardly, a splicing tape is respectively fixedly connected in the two opposed ends of protective layer, aerogel dressing layer bottom,
Adhesion has a dustproof membrane respectively for each splicing tape bottom.
Preferably, the reclinate angle of bottom edge of the aerogel dressing layer is 30 degree of -90 degree.
Preferably, the surface of the aerogel dressing layer is equipped with several spaced air-permeable pin-holes.It can be effectively
Guarantee gas permeability, at the same in setting by air-permeable pin-holes setting it is relatively thin a bit, so as to be effectively prevented its dust of magazine
Entrance.
Preferably, the protective layer is the anti-bacteria cloth bed of material of vapor-permeable type.
Preferably, the splicing tape is elastic cloth.
Preferably, the aerogel dressing layer includes the component of following mass fraction: 100-500 parts of hydroxypropyl, hydroxyl butyl
100-500 parts of chitosan, 200-400 parts of sodium alginate, 20-50 parts of low-fat pectin, 30-80 parts of antimicrobial nano silver powder, medium-height grass
100-200 parts of medicine medicament.
It preferably, further include 50-100 parts of collagen, 3-5 parts of ZnO powder.ZnO powder can effectively promote
Into the healing of wound, Chinese medicinal herb medicament is cooperated to realize preferably effect.
Preferably, the Chinese medicinal herb medicament includes the mushroom extract of identical mass fraction and same concentrations, Radix Notoginseng extraction
Liquid, Caulis Spatholobi extracting solution, calcined Dragon's bone extracting solution；It further include the low-concentration ethanol solution of identical mass fraction；With obtained Chinese herbal medicine
Medicament can well effectively treat realization at injury, the healing of deceleration wound.
A kind of preparation method of nano silver composite hydrogel dressing patch, specific steps include:
S1: plural gel is prepared:
It will enter sodium hydroxide solution is added after mixing hydroxypropyl, hydroxyl butyl chitosan, sodium alginate according to above-mentioned mass fraction,
The aldehyde radical of schiff base reaction is provided using oxidized sodium alginate, forms the covalent dual network of crystallization-of chemical crosslinking after reaction, is obtained just
Grade plural gel solution；
S2: mixing stirring:
Low-fat pectin, Chinese medicinal herb medicament, collagen are added into plural gel solution obtained in S1 to be stirred；
S3: being added sodium chloride solution, be kept stirring, the covalent double nets of the chain entanglement-that sodium chloride solution is physical crosslinking after being added
Network obtains second level plural gel solution；
S4: products therefrom in S3 is radiated by high-energy ray, primary hydrogel material is made；
S5: product obtained in S4 is dipped in the silver salt solution dissolved with antimicrobial nano silver powder, hydrogel material is absorbed
Load silver ion and adsorption antibacterial nano silver, obtain silver ionized water gel dressing in silver salt solution；
S6: will be stand-by after the progress vacuum defoamation of second level plural gel solution obtained in S5；
S7: mold inner-cavity bottom sprays appropriate ZnO powder after placing dustproof membrane, and the product injection in S6 is then met water
In the mold of gel rubber material design size, the anti-bacteria cloth bed of material of bonding splicing tape is applied to the product table in the S6 in mold
Hydrogel material semi-finished product are made in face, covering backing material；
S8: being pressed by the press head with several fine steel needles on press machine, discharge by pressing air-permeable pin-holes, stand 1-2h,
After demoulding, final nano silver composite hydrogel dressing patch is obtained.
The present invention has the beneficial effects that
The structure design of the corner of the present apparatus can effectively enhance the trend that aerogel dressing layer edge is drawn close to skin, together
When can effectively act as the problem of preventing corner from tilting, be effectively guaranteed safety in use.The present apparatus exists
Group, which is grouped as, can bring following effect: it is highly-safe when use, the aldehyde of schiff base reaction is provided using oxidized sodium alginate
Base avoids the introducing of toxic chemical crosslinking agent；Using chitosan and sodium alginate as main material, have both two kinds of material moisturizings,
A variety of advantages such as antibacterial, blood coagulation, degradation, water suction；In preparation process, chemical crosslinking+physical crosslinking dual network structure is generated, is changed
It has been apt to the physical mechanical property of gel；Have the characteristics that moisturizing is ventilative when in use, the condition of wound wet union can be met,
Improve the power of regeneration of epidermal cell；Chitosan, which is added, makes it have a variety of antibacterials, anti-inflammatory, hemoglutination；Have good molten
Swollen rate is good to diffusate absorbability.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of this nano silver composite hydrogel dressing patch.
In figure, 1, aerogel dressing layer；2, protective layer；3, splicing tape；4, dustproof membrane；5, air-permeable pin-holes.
Specific embodiment
In order to clarify the technical characteristics of the invention, below by specific embodiment, and its attached drawing is combined, to this hair
It is bright to be described in detail.
As shown in fig. 1, a kind of nano silver composite hydrogel dressing patch, including an aerogel dressing layer 1 are applied in hydrogel
Fixed one protective layer 2 of adhesion in the top of the bed of material 1, the bottom edge of the aerogel dressing layer 1 is bent downwardly, in protective layer 2
Two opposed ends a splicing tape 3 is respectively fixedly connected, 1 bottom of aerogel dressing layer, 3 bottom of each splicing tape respectively adhesion have it is one anti-
Dirt film 4 effectively acts as the effect of dust-proof protection when not in use.By the way that splicing tape 3 is arranged, the energy when carrying out using bonding
It is enough that entire dressing patch is effectively adhered to the surface at injury, it is bonded stronger.
Preferably, the reclinate angle [alpha] of bottom edge of the aerogel dressing layer 1 is 30 degree of -90 degree, by hydrogel
The periphery of dressing layer 1 is arranged to reclinate structure, since aerogel dressing layer 1 itself has certain elasticity, works as use
When this aerogel dressing layer 1 is bonded on the skin of human body, the middle part of aerogel dressing layer 1 can be protected at injury well,
If patient is the phenomenon that movable existing aerogel dressing layer 1 in the process is tilted it is easy to appear corner, in this way after bonding
External dust, bacterium is just easily caused to enter at skin injury；The structure design of the corner of the present apparatus can effectively enhance
The trend that 1 edge of aerogel dressing layer is drawn close to skin, while the problem of preventing corner from tilting can be effectively acted as, effectively
Ground ensure that safety in use.
Preferably, the surface of the aerogel dressing layer 1 is equipped with several spaced air-permeable pin-holes 5.It can be effective
Ground guarantees gas permeability, at the same in setting by air-permeable pin-holes 5 be arranged it is relatively thin a bit, so as to be effectively prevented its ash of magazine
The entrance of dirt.
Preferably, the protective layer 2 is the anti-bacteria cloth bed of material of vapor-permeable type.
Preferably, the splicing tape 3 is elastic cloth.
Preferably, the aerogel dressing layer 1 includes the component of following mass fraction: 100-500 parts of hydroxypropyl, hydroxyl butyl
100-500 parts of chitosan, 200-400 parts of sodium alginate, 20-50 parts of low-fat pectin, 30-80 parts of antimicrobial nano silver powder, medium-height grass
100-200 parts of medicine medicament.Using chitosan and sodium alginate as main material, have both two kinds of material moisturizings, antibacterial, blood coagulation, degradation,
A variety of advantages such as water suction.
It preferably, further include 50-100 parts of collagen, 3-5 parts of ZnO powder.
Preferably, the Chinese medicinal herb medicament includes the mushroom extract of identical mass fraction and same concentrations, Radix Notoginseng extraction
Liquid, Caulis Spatholobi extracting solution, calcined Dragon's bone extracting solution；It further include the low-concentration ethanol solution of identical mass fraction.
A kind of preparation method of nano silver composite hydrogel dressing patch, specific steps include:
S1: plural gel is prepared:
It will enter sodium hydroxide solution is added after mixing hydroxypropyl, hydroxyl butyl chitosan, sodium alginate according to above-mentioned mass fraction,
The aldehyde radical of schiff base reaction is provided using oxidized sodium alginate, forms the covalent dual network of crystallization-of chemical crosslinking after reaction, is obtained just
Grade plural gel solution；
S2: mixing stirring:
Low-fat pectin, Chinese medicinal herb medicament, collagen are added into plural gel solution obtained in S1 to be stirred；
S3: being added sodium chloride solution, be kept stirring, the covalent double nets of the chain entanglement-that sodium chloride solution is physical crosslinking after being added
Network obtains second level plural gel solution；In preparation process, chemical crosslinking+physical crosslinking dual network structure is generated, gel is improved
Physical mechanical property；
S4: products therefrom in S3 is radiated by high-energy ray, primary hydrogel material is made；
S5: product obtained in S4 is dipped in the silver salt solution dissolved with antimicrobial nano silver powder, hydrogel material is absorbed
Load silver ion and adsorption antibacterial nano silver, obtain silver ionized water gel dressing in silver salt solution；
S6: will be stand-by after the progress vacuum defoamation of second level plural gel solution obtained in S5；
S7: mold inner-cavity bottom sprays appropriate ZnO powder after placing dustproof membrane 4, and the product in S6 is then injected symbol
In the mold of Heshui gel rubber material design size, the anti-bacteria cloth bed of material of bonding splicing tape 3 is applied to the production in the S6 in mold
Hydrogel material semi-finished product are made in object surface, covering backing material；The surface contacted at finally formed dressing patch and injury is
It is bonded with certain ZnO powder, the quick healing of wound can be effectively facilitated, improves therapeutic effect.
S8: being pressed by the press head with several fine steel needles on press machine, and discharge by pressing air-permeable pin-holes 5 are stood
After 1-2h, demoulding, final nano silver composite hydrogel dressing patch is obtained.
Embodiment 1:
A kind of preparation method of nano silver composite hydrogel dressing patch, specific steps include:
S1: plural gel is prepared:
It will will enter to add after 100 parts of hydroxypropyl, 500 parts of hydroxyl butyl chitosan, 200 parts of sodium alginate mixing according to above-mentioned mass fraction
Enter 1000 parts of mass fraction of sodium hydroxide solution, the concentration of sodium hydroxide solution have in selection staff as needed into
Row selection, each component of being subject to can be realized sufficiently reaction and do not waste raw material, specifically repeat no more and voluntarily set by technical staff
Calmly, the aldehyde radical of schiff base reaction is provided using the sodium alginate of oxidation when reaction, the crystallization-that chemical crosslinking is formed after reaction is covalent
Dual network obtains primary plural gel solution；
S2: mixing stirring:
Be added into plural gel solution obtained in S1 20 parts of low-fat pectin, 100 parts of Chinese medicinal herb medicament, 50 parts of collagen into
Row stirring；
S3: being added suitable sodium chloride solution, be kept stirring, and the chain entanglement-that sodium chloride solution is physical crosslinking after being added is altogether
Valence dual network obtains second level plural gel solution；
S4: products therefrom in S3 is radiated by high-energy ray, primary hydrogel material is made；
S5: product obtained in S4 is dipped in the silver salt solution dissolved with 30 parts of antimicrobial nano silver powder, hydrogel material is made
Load silver ion and adsorption antibacterial nano silver in silver salt solution are absorbed, silver ionized water gel dressing is obtained；
S6: will be stand-by after the progress vacuum defoamation of second level plural gel solution obtained in S5；
S7: mold inner-cavity bottom sprays appropriate ZnO powder after placing dustproof membrane 4, and the product injection in S6 is then met water
In the mold of gel rubber material design size, the anti-bacteria cloth bed of material of bonding splicing tape 3 is applied to the product table in the S6 in mold
Hydrogel material semi-finished product are made in face, covering backing material；
S8: being pressed by the press head with several fine steel needles on press machine, discharge by pressing air-permeable pin-holes 5, stand 1-2h,
After demoulding, final nano silver composite hydrogel dressing patch is obtained.
Embodiment 2:
A kind of preparation method of nano silver composite hydrogel dressing patch, specific steps include:
S1: plural gel is prepared:
It will will enter to add after 200 parts of hydroxypropyl, 400 parts of hydroxyl butyl chitosan, 200 parts of sodium alginate mixing according to above-mentioned mass fraction
Enter 1000 parts of mass fraction of sodium hydroxide solution, the concentration of sodium hydroxide solution have in selection staff as needed into
Row selection, each component of being subject to can be realized sufficiently reaction and do not waste raw material, specifically repeat no more and voluntarily set by technical staff
Calmly, the aldehyde radical of schiff base reaction is provided using the sodium alginate of oxidation when reaction, the crystallization-that chemical crosslinking is formed after reaction is covalent
Dual network obtains primary plural gel solution；
S2: mixing stirring:
Be added into plural gel solution obtained in S1 30 parts of low-fat pectin, 120 parts of Chinese medicinal herb medicament, 70 parts of collagen into
Row stirring；
S3: being added suitable sodium chloride solution, be kept stirring, and the chain entanglement-that sodium chloride solution is physical crosslinking after being added is altogether
Valence dual network obtains second level plural gel solution；
S4: products therefrom in S3 is radiated by high-energy ray, primary hydrogel material is made；
S5: product obtained in S4 is dipped in the silver salt solution dissolved with 40 parts of antimicrobial nano silver powder, hydrogel material is made
Load silver ion and adsorption antibacterial nano silver in silver salt solution are absorbed, silver ionized water gel dressing is obtained；
S6: will be stand-by after the progress vacuum defoamation of second level plural gel solution obtained in S5；
S7: mold inner-cavity bottom sprays appropriate ZnO powder after placing dustproof membrane 4, and the product injection in S6 is then met water
In the mold of gel rubber material design size, the anti-bacteria cloth bed of material of bonding splicing tape 3 is applied to the product table in the S6 in mold
Hydrogel material semi-finished product are made in face, covering backing material；
Embodiment 3:
A kind of preparation method of nano silver composite hydrogel dressing patch, specific steps include:
S1: plural gel is prepared:
It will will enter to add after 300 parts of hydroxypropyl, 300 parts of hydroxyl butyl chitosan, 300 parts of sodium alginate mixing according to above-mentioned mass fraction
Enter 1000 parts of mass fraction of sodium hydroxide solution, the concentration of sodium hydroxide solution have in selection staff as needed into
Row selection, each component of being subject to can be realized sufficiently reaction and do not waste raw material, specifically repeat no more and voluntarily set by technical staff
Calmly, the aldehyde radical of schiff base reaction is provided using the sodium alginate of oxidation when reaction, the crystallization-that chemical crosslinking is formed after reaction is covalent
Dual network obtains primary plural gel solution；
S2: mixing stirring:
Be added into plural gel solution obtained in S1 35 parts of low-fat pectin, 160 parts of Chinese medicinal herb medicament, 80 parts of collagen into
Row stirring；
S3: being added suitable sodium chloride solution, be kept stirring, and the chain entanglement-that sodium chloride solution is physical crosslinking after being added is altogether
Valence dual network obtains second level plural gel solution；
S4: products therefrom in S3 is radiated by high-energy ray, primary hydrogel material is made；
S5: product obtained in S4 is dipped in the silver salt solution dissolved with 50 parts of antimicrobial nano silver powder, hydrogel material is made
Load silver ion and adsorption antibacterial nano silver in silver salt solution are absorbed, silver ionized water gel dressing is obtained；
S6: will be stand-by after the progress vacuum defoamation of second level plural gel solution obtained in S5；
S7: mold inner-cavity bottom sprays appropriate ZnO powder after placing dustproof membrane 4, and the product injection in S6 is then met water
In the mold of gel rubber material design size, the anti-bacteria cloth bed of material of bonding splicing tape 3 is applied to the product table in the S6 in mold
Hydrogel material semi-finished product are made in face, covering backing material；
S8: being pressed by the press head with several fine steel needles on press machine, discharge by pressing air-permeable pin-holes 5, stand 1-2h,
After demoulding, final nano silver composite hydrogel dressing patch is obtained.
Embodiment 4:
A kind of preparation method of nano silver composite hydrogel dressing patch, specific steps include:
S1: plural gel is prepared:
It will will enter to add after 400 parts of hydroxypropyl, 200 parts of hydroxyl butyl chitosan, 400 parts of sodium alginate mixing according to above-mentioned mass fraction
Enter 1000 parts of mass fraction of sodium hydroxide solution, the concentration of sodium hydroxide solution have in selection staff as needed into
Row selection, each component of being subject to can be realized sufficiently reaction and do not waste raw material, specifically repeat no more and voluntarily set by technical staff
Calmly, the aldehyde radical of schiff base reaction is provided using the sodium alginate of oxidation when reaction, the crystallization-that chemical crosslinking is formed after reaction is covalent
Dual network obtains primary plural gel solution；
S2: mixing stirring:
Be added into plural gel solution obtained in S1 40 parts of low-fat pectin, 180 parts of Chinese medicinal herb medicament, 80 parts of collagen into
Row stirring；
S3: being added suitable sodium chloride solution, be kept stirring, and the chain entanglement-that sodium chloride solution is physical crosslinking after being added is altogether
Valence dual network obtains second level plural gel solution；
S4: products therefrom in S3 is radiated by high-energy ray, primary hydrogel material is made；
S5: product obtained in S4 is dipped in the silver salt solution dissolved with 60 parts of antimicrobial nano silver powder, hydrogel material is made
Load silver ion and adsorption antibacterial nano silver in silver salt solution are absorbed, silver ionized water gel dressing is obtained；
S6: will be stand-by after the progress vacuum defoamation of second level plural gel solution obtained in S5；
S7: mold inner-cavity bottom sprays appropriate ZnO powder after placing dustproof membrane 4, and the product injection in S6 is then met water
In the mold of gel rubber material design size, the anti-bacteria cloth bed of material of bonding splicing tape 3 is applied to the product table in the S6 in mold
Hydrogel material semi-finished product are made in face, covering backing material；
S8: being pressed by the press head with several fine steel needles on press machine, discharge by pressing air-permeable pin-holes 5, stand 1-2h,
After demoulding, final nano silver composite hydrogel dressing patch is obtained.
Embodiment 5:
A kind of preparation method of nano silver composite hydrogel dressing patch, specific steps include:
S1: plural gel is prepared:
It will will enter to add after 500 parts of hydroxypropyl, 100 parts of hydroxyl butyl chitosan, 400 parts of sodium alginate mixing according to above-mentioned mass fraction
Enter 1000 parts of mass fraction of sodium hydroxide solution, the concentration of sodium hydroxide solution have in selection staff as needed into
Row selection, each component of being subject to can be realized sufficiently reaction and do not waste raw material, specifically repeat no more and voluntarily set by technical staff
Calmly, the aldehyde radical of schiff base reaction is provided using the sodium alginate of oxidation when reaction, the crystallization-that chemical crosslinking is formed after reaction is covalent
Dual network obtains primary plural gel solution；
S2: mixing stirring:
50 parts of low-fat pectin, 200 parts of Chinese medicinal herb medicament, 100 parts of collagen are added into plural gel solution obtained in S1
It is stirred；
S3: being added suitable sodium chloride solution, be kept stirring, and the chain entanglement-that sodium chloride solution is physical crosslinking after being added is altogether
Valence dual network obtains second level plural gel solution；
S4: products therefrom in S3 is radiated by high-energy ray, primary hydrogel material is made；
S5: product obtained in S4 is dipped in the silver salt solution dissolved with 80 parts of antimicrobial nano silver powder, hydrogel material is made
Load silver ion and adsorption antibacterial nano silver in silver salt solution are absorbed, silver ionized water gel dressing is obtained；
S6: will be stand-by after the progress vacuum defoamation of second level plural gel solution obtained in S5；
S7: mold inner-cavity bottom sprays appropriate ZnO powder after placing dustproof membrane 4, and the product injection in S6 is then met water
In the mold of gel rubber material design size, the anti-bacteria cloth bed of material of bonding splicing tape 3 is applied to the product table in the S6 in mold
Hydrogel material semi-finished product are made in face, covering backing material；
S8: being pressed by the press head with several fine steel needles on press machine, discharge by pressing air-permeable pin-holes 5, stand 1-2h,
After demoulding, final nano silver composite hydrogel dressing patch is obtained.
What the structure design of the corner of the present apparatus can effectively enhance that 1 edge of aerogel dressing layer draw close to skin becomes
Gesture, while the problem of preventing corner from tilting can be effectively acted as, it is effectively guaranteed safety in use.This dress
Following effect can be brought on group is grouped as by setting: it is highly-safe when use, schiff base reaction is provided using oxidized sodium alginate
Aldehyde radical, avoid the introducing of toxic chemical crosslinking agent；Using chitosan and sodium alginate as main material, has both two kinds of materials and protect
A variety of advantages such as wet, antibacterial, blood coagulation, degradation, water suction；In preparation process, chemical crosslinking+physical crosslinking dual network knot is generated
Structure improves the physical mechanical property of gel；Have the characteristics that moisturizing is ventilative when in use, wound wet union can be met
Condition improves the power of regeneration of epidermal cell；Chitosan, which is added, makes it have a variety of antibacterials, anti-inflammatory, hemoglutination；Have good
Swelling ratio it is good to diffusate absorbability.
Above-mentioned specific embodiment cannot function as limiting the scope of the invention, for the technology people of the art
For member, any alternate modification or transformation made to embodiment of the present invention are fallen within the scope of protection of the present invention.
Place is not described in detail by the present invention, is the well-known technique of those skilled in the art of the present technique.
Claims (9)
1. a kind of nano silver composite hydrogel dressing patch, it is characterised in that: including an aerogel dressing layer, in aerogel dressing layer
Fixed one protective layer of adhesion in top, the bottom edge of the aerogel dressing layer is bent downwardly, and two in protective layer are opposite
A splicing tape is respectively fixedly connected in end, and in aerogel dressing layer bottom, each splicing tape bottom, adhesion has a dustproof membrane respectively.
2. a kind of nano silver composite hydrogel dressing patch according to claim 1, it is characterised in that: the aerogel dressing
The reclinate angle of bottom edge of layer is 30 degree of -90 degree.
3. a kind of nano silver composite hydrogel dressing patch according to claim 2, it is characterised in that: the aerogel dressing
The surface of layer is equipped with several spaced air-permeable pin-holes.
4. a kind of nano silver composite hydrogel dressing patch according to claim 3, it is characterised in that: the protective layer is
The anti-bacteria cloth bed of material of gas type.
5. a kind of nano silver composite hydrogel dressing patch according to claim 4, it is characterised in that: the splicing tape is bullet
Power cloth.
6. a kind of nano silver composite hydrogel dressing patch according to claim 5, it is characterised in that: the aerogel dressing
Layer includes the component of following mass fraction: 100-500 parts of hydroxypropyl, 100-500 parts of hydroxyl butyl chitosan, sodium alginate 200-
400 parts, 20-50 parts of low-fat pectin, 30-80 parts of antimicrobial nano silver powder, 100-200 parts of Chinese medicinal herb medicament.
7. a kind of nano silver composite hydrogel dressing patch according to claim 6, it is characterised in that: further include collagen
50-100 parts, 3-5 parts of ZnO powder.
8. a kind of nano silver composite hydrogel dressing patch according to claim 5, it is characterised in that: the Chinese medicinal herb medicament
Mushroom extract, Radix Notoginseng extracting solution, Caulis Spatholobi extracting solution, calcined Dragon's bone extracting solution including identical mass fraction and same concentrations；
It further include the low-concentration ethanol solution of identical mass fraction.
9. a kind of preparation method of nano silver composite hydrogel dressing patch, it is characterised in that: its specific steps includes:
S1: plural gel is prepared:
It will enter sodium hydroxide solution is added after mixing hydroxypropyl, hydroxyl butyl chitosan, sodium alginate according to above-mentioned mass fraction,
The aldehyde radical of schiff base reaction is provided using oxidized sodium alginate, forms the covalent dual network of crystallization-of chemical crosslinking after reaction, is obtained just
Grade plural gel solution；
S2: mixing stirring:
Low-fat pectin, Chinese medicinal herb medicament, collagen are added into plural gel solution obtained in S1 to be stirred；
S3: being added sodium chloride solution, be kept stirring, the covalent double nets of the chain entanglement-that sodium chloride solution is physical crosslinking after being added
Network obtains second level plural gel solution；
S4: products therefrom in S3 is radiated by high-energy ray, primary hydrogel material is made；
S5: product obtained in S4 is dipped in the silver salt solution dissolved with antimicrobial nano silver powder, hydrogel material is absorbed
Load silver ion and adsorption antibacterial nano silver, obtain silver ionized water gel dressing in silver salt solution；
S6: will be stand-by after the progress vacuum defoamation of second level plural gel solution obtained in S5；
S7: mold inner-cavity bottom sprays appropriate ZnO powder after placing dustproof membrane, and then dustproof membrane is placed in mold inner-cavity bottom
After spray appropriate ZnO powder, then the product injection in S6 is met in the mold of hydrogel material design size, will be glued
The anti-bacteria cloth bed of material for connecting splicing tape applies surface in the S6 in mold, and hydrogel material half is made in covering backing material
Finished product；
S8: being pressed by the press head with several fine steel needles on press machine, discharge by pressing air-permeable pin-holes, stand 1-2h,
After demoulding, final nano silver composite hydrogel dressing patch is obtained.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111234265A (en) * | 2020-03-03 | 2020-06-05 | 中国科学院化学研究所 | Preparation method of medical multifunctional hydrogel dressing |
| CN115429931A (en) * | 2022-10-24 | 2022-12-06 | 山东爱基康健康科技有限公司 | Chitosan hydrogel dressing containing exosome and preparation method thereof |
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| CN115429931B (en) * | 2022-10-24 | 2023-08-15 | 山东爱基康健康科技有限公司 | Chitosan hydrogel dressing containing exosomes and preparation method thereof |
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