CN106267316B - Anti- dehydration gecko hydrogel application of one kind and preparation method thereof - Google Patents
Anti- dehydration gecko hydrogel application of one kind and preparation method thereof Download PDFInfo
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- CN106267316B CN106267316B CN201610692571.5A CN201610692571A CN106267316B CN 106267316 B CN106267316 B CN 106267316B CN 201610692571 A CN201610692571 A CN 201610692571A CN 106267316 B CN106267316 B CN 106267316B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/58—Adhesives
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Abstract
The invention belongs to medical macromolecular materials fields, and the invention discloses a kind of anti-dehydration gecko hydrogel applications and preparation method thereof, and the raw material including following parts by weight is made: polyvinyl alcohol 0.25-1.55；Polyglutamic acid 0.04-0.27；Tannic acid 0.03-0.35；Mass concentration is the glutaraldehyde 0.05-0.12 of 2-10%；Water 10-23；It the rest is acid regulator; there is the application surface that the present invention is prepared the tissue of similar gecko sole nanometer sucker structure can adsorb abutting human skin surface; to effectively prevent falling off; hydrogel dehydration can be effectively prevented again simultaneously; hydrogel application produced by the present invention can play self-cleaning effects with skin good fit, and be suitable for cold compress physical therapy, burn, protecting wound surface and the treatment of scald and traumatic wounds.
Description
Technical field
The invention belongs to medical macromolecular materials field, in particular to a kind of anti-dehydration gecko hydrogel application and its preparation
Method.
Background technique
Dressing is essential medical supplies, and easily with skin wound tissue adhesion, dressing destroys newly traditional dressing often
Raw epithelium and granulation tissue, cause bleeding, are unfavorable for wound healing, and make Principle of Pain unbearably.Hydrogel is a kind of with three
The soft wet stock of reticular structure is tieed up, the bionical characteristic such as high-moisture, adhesion wound, good biocompatibility makes it in Medical coating
It is used widely in material field.
But current high-end aerogel dressing is primarily present following two technical barrier: one, tissue integration is poor, i.e., with tissue
Be bonded not close, cannot play the role of actively promoting wound repair, current solution predominantly by hydrogel application with
Medical adhesive tape is used cooperatively, and plays the fixed effect of physics, or be coated with medical glue in gel surface, but can not be from root
Solve the problems, such as that dressing is efficiently bonded with organization security in sheet；Two, hydrogel is easy dehydration in air and causes structure destruction, function
The problems such as effect reduces, main solution is that hydrogel is stored in low temperature and high relative humidity environment at present, effectively but without one
The method for solving aerogel dressing dehydration in clinic.
Summary of the invention
In order to make up the above deficiency, the object of the present invention is to provide a kind of anti-dehydration gecko hydrogel application and its preparation sides
Method, to solve the problem of that the not high clinical use of compactness is easily dehydrated in above-mentioned background technique.
The technical solution of the present invention is as follows:
A kind of anti-dehydration gecko hydrogel application, the raw material including following parts by weight are made:
Polyvinyl alcohol 0.25-1.55；
Polyglutamic acid 0.04-0.27；
Tannic acid 0.03-0.35；
Mass concentration is the glutaraldehyde 0.05-0.12 of 2-10%；
Water 10-23；
It the rest is acid regulator.
As a preferred option,
Polyvinyl alcohol 1.55；
Polyglutamic acid 0.15；
Tannic acid 0.22；
The glutaraldehyde 0.06 that mass concentration is 5%；
Water 20；
It the rest is acid regulator
As a preferred option, acid regulator is hydrochloric acid.
The invention also includes a kind of methods for preparing anti-dehydration gecko gel application, it is characterised in that:
1) each component is weighed by formula, the polyvinyl alcohol of 0.25-1.55 parts by weight is added to the water, carried out at 80-90 DEG C
Water-bath dissolution；
2) acid regulator is added in the above solution, adjusting pH value of solution is 2-4, and 0.04-0.27 parts by weight are then added
Polyglutamic acid and 0.03-0.35 parts by weight tannic acid, at 25-45 DEG C stirring to dissolve；
3) mass concentration that 0.05-0.12 parts by weight are added is the glutaraldehyde of 2-10%, and after mixing evenly, ultrasound goes degasification
Bubble, is applied in nano-silicon sheet mold, stands crosslinking 10-60min, obtains hydrogel；
4) hydrogel prepared is uniformly coated on non-woven fabrics, then covers polyethylene film above and is formed
Hydrogel application.
As a preferred option, the acid regulator is hydrochloric acid.
As a preferred option, water-bath dissolution is carried out at 88 DEG C of the step 1)；.
As a preferred option, it is 3. that the step 2), which adjusts pH value of solution,
As a preferred option, stirring is extremely dissolved at 35 DEG C in the step 2).
The present invention has the advantage that
1, there is gecko vola nano bionic structure using the medical hydrogel wound dressing surface of the method for the present invention preparation,
With high stemness condition matrix adhesive force, while tannic acid is the polyphenol hydroxyl material from plant, is had good
Hydrogen bond at keyness, there is excellent moist bonding effect, the two combines can guarantee that application is efficiently bonded with the surface of a wound simultaneously, but
Not glutinous viscous wound, has wound self-cleaning effect
2, the present invention used in polyvinyl alcohol be high resiliency, chemical stability, it is easy to form, have no toxic side effect to organism and
With the good compatibility of tissue, polyglutamic acid is native biopolymer material, has excellent moisture retention, can be effective
Prevent hydrogel to be dehydrated, while there is preferable bioactivity and cell adhesion, can effectively facilitate surface of a wound cell adherency,
Growth and proliferation promote the wet healing of the surface of a wound
3, the present invention prepares hydrogel application using glutaraldehyde cross-linking, and preparation process is simple, and biological safety is preferable, the later period
Purification process is convenient, is suitble to technique amplification production.
Specific embodiment
A kind of anti-dehydration gecko hydrogel application, the raw material including following parts by weight are made:
Polyvinyl alcohol 0.25-1.55；
Polyglutamic acid 0.04-0.27；
Tannic acid 0.03-0.35；
Mass concentration is the glutaraldehyde 0.05-0.12 of 2-10%；
Water 10-23；
It the rest is acid regulator.
Preferably, polyvinyl alcohol 1.55；
Polyglutamic acid 0.15；
Tannic acid 0.22；
The glutaraldehyde 0.06 that mass concentration is 5%；
Water 20；
It the rest is acid regulator
Preferably, acid regulator is hydrochloric acid.
A method of preparing anti-dehydration gecko gel application, it is characterised in that:
1) each component is weighed by formula, the polyvinyl alcohol of 0.25-1.55 parts by weight is added to the water, carried out at 80-90 DEG C
Water-bath dissolution；
2) acid regulator is added in the above solution, adjusting pH value of solution is 2-4, and 0.04-0.27 parts by weight are then added
Polyglutamic acid and 0.03-0.35 parts by weight tannic acid, at 25-45 DEG C stirring to dissolve；
3) mass concentration that 0.05-0.12 parts by weight are added is the glutaraldehyde of 2-10%, and after mixing evenly, ultrasound goes degasification
Bubble, is applied in nano-silicon sheet mold, stands crosslinking 10-60min, obtains hydrogel；
4) hydrogel prepared is uniformly coated on non-woven fabrics, then covers polyethylene film above and is formed
Hydrogel application.
In order to be easy to understand the technical means, the creative features, the aims and the efficiencies achieved by the present invention, tie below
Specific embodiment is closed, the present invention is further explained.
Embodiment 1
1) weigh each component by formula, the polyvinyl alcohol of 0.25 parts by weight be added in the water of 10 parts by weight, at 80 DEG C into
Row water-bath dissolution；
2) be added hydrochloric acid in the above solution, adjusting pH value of solution is 2, be then added 0.04 parts by weight polyglutamic acid and
The tannic acid of 0.03 parts by weight, stirring is extremely dissolved at 25 DEG C；
3) glutaraldehyde that the mass concentration of 0.05 parts by weight is 2% is added, after mixing evenly, ultrasound removes bubble removing, coating
Into nano-silicon sheet mold, crosslinking 10min is stood, hydrogel is obtained；
4) hydrogel prepared is uniformly coated on non-woven fabrics, then covers polyethylene film above and is formed
Hydrogel application.
Embodiment 2
1) weigh each component by formula, the polyvinyl alcohol of 1.55 parts by weight be added in the water of 23 parts by weight, at 90 DEG C into
Row water-bath dissolution；
2) be added hydrochloric acid in the above solution, adjusting pH value of solution is 4, be then added 0.27 parts by weight polyglutamic acid and
The tannic acid of 0.35 parts by weight, stirring is extremely dissolved at 45 DEG C；
3) glutaraldehyde that the mass concentration of 0.12 parts by weight is 10% is added, after mixing evenly, ultrasound removes bubble removing, coating
Into nano-silicon sheet mold, crosslinking 60min is stood, hydrogel is obtained；
4) hydrogel prepared is uniformly coated on non-woven fabrics, then covers polyethylene film above and is formed
Hydrogel application.
Embodiment 3
1) weigh each component by formula, the polyvinyl alcohol of 0.8 parts by weight be added in the water of 17 parts by weight, at 88 DEG C into
Row water-bath dissolution；
2) be added hydrochloric acid in the above solution, adjusting pH value of solution is 3, be then added 0.04 parts by weight polyglutamic acid and
The tannic acid of 0.03 parts by weight, stirring is extremely dissolved at 35 DEG C；
3) glutaraldehyde that the mass concentration of 0.12 parts by weight is 5% is added, after mixing evenly, ultrasound removes bubble removing, coating
Into nano-silicon sheet mold, crosslinking 20min is stood, hydrogel is obtained；
4) hydrogel prepared is uniformly coated on non-woven fabrics, then covers polyethylene film above and is formed
Hydrogel application.
Embodiment 4
1) weigh each component by formula, the polyvinyl alcohol of 0.25 parts by weight be added in the water of 10 parts by weight, at 88 DEG C into
Row water-bath dissolution；
2) be added hydrochloric acid in the above solution, adjusting pH value of solution is 3, be then added 0.15 parts by weight polyglutamic acid and
The tannic acid of 0.22 parts by weight, stirring is extremely dissolved at 35 DEG C；
3) glutaraldehyde that the mass concentration of 0.06 parts by weight is 5% is added, after mixing evenly, ultrasound removes bubble removing, coating
Into nano-silicon sheet mold, crosslinking 20min is stood, hydrogel is obtained；
4) hydrogel prepared is uniformly coated on non-woven fabrics, then covers polyethylene film above and is formed
Hydrogel application.
Embodiment 5
1) weigh each component by formula, the polyvinyl alcohol of 1.55 parts by weight be added in the water of 20 parts by weight, at 88 DEG C into
Row water-bath dissolution；
2) be added hydrochloric acid in the above solution, adjusting pH value of solution is 3, be then added 0.15 parts by weight polyglutamic acid and
The tannic acid of 0.22 parts by weight, stirring is extremely dissolved at 35 DEG C；
3) glutaraldehyde that the mass concentration of 0.06 parts by weight is 5% is added, after mixing evenly, ultrasound removes bubble removing, coating
Into nano-silicon sheet mold, crosslinking 20min is stood, hydrogel is obtained；
4) hydrogel prepared is uniformly coated on non-woven fabrics, then covers polyethylene film above and is formed
Hydrogel application.
Embodiment 6
1) each component is weighed by formula, the polyvinyl alcohol of 0.68g parts by weight is added to the water, it is molten that water-bath is carried out at 88 DEG C
Solution；
2) be added hydrochloric acid in the above solution, adjusting pH value of solution is 3, be then added 0.27 parts by weight polyglutamic acid and
The tannic acid of 0.35 parts by weight, stirring is extremely dissolved at 34 DEG C；
3) glutaraldehyde that the mass concentration of 0.05 parts by weight is 5% is added, after mixing evenly, ultrasound removes bubble removing, coating
Into nano-silicon sheet mold, crosslinking 20min is stood, hydrogel is obtained；
4) hydrogel prepared is uniformly coated on non-woven fabrics, then covers polyethylene film above and is formed
Hydrogel application.
The scheme of the invention is: in order to further prove that the present invention has substantive distinguishing features and conspicuousness progress, to implementation
Anti- dehydration gecko hydrogel application prepared by example 3 to 6, using orthogonal experiment to the initial bonding strength of gained hydrogel application, skin
Skin tracing ability, moisture retention measure, and result is to be respectively as follows:
Embodiment 3 is as follows:
Peel strength: 0.04/0.5kg
Skin tracing ability: it is affixed under getting rid of 10 on skin not fall
Water-retaining property: 91%
Embodiment 4 is as follows:
Peel strength: 0.02/0.5kg
Skin tracing ability: it is affixed under getting rid of 10 on skin not fall
Water-retaining property: 89%
Embodiment 5 is as follows:
Peel strength: 0.06/0.5kg
Skin tracing ability: it is affixed under getting rid of 10 on skin not fall
Water-retaining property: 96%
Embodiment 6 is as follows:
Peel strength: 0.05/0.5kg
Skin tracing ability: it is affixed under getting rid of 10 on skin not fall
Water-retaining property: 93%
Initial bonding strength by the orthogonal experiment of above-described embodiment 3 to 6 to gained hydrogel application, skin tracing ability, moisturizing
Property measure data from the point of view of, initial bonding strength, skin tracing ability can reach medical level requirement, and water-retaining property is even more super
88% or more is crossed, therefore the visible present invention is with substantive distinguishing features and conspicuousness progress.
The above only depicts basic principles and main features and advantages of the present invention of the invention.The skill of the industry
Art personnel it should be appreciated that the present invention is not limited to the above embodiments, the above embodiments and description only describe
The principle of the present invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these
Changes and improvements all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and
Its equivalent circle.
Claims (5)
1. a kind of preparation method of anti-dehydration gecko hydrogel application, which is characterized in that anti-dehydration gecko hydrogel application includes
The raw material of following parts by weight is made:
Polyvinyl alcohol 0.25-1.55；
Polyglutamic acid 0.04-0.27；
Tannic acid 0.03-0.35；
Mass concentration is the glutaraldehyde 0.05-0.12 of 2-10%；
Water 10-23；
It the rest is acid regulator, the acid regulator is hydrochloric acid；
Preparation method includes the following steps:
1) each component is weighed by formula, the polyvinyl alcohol of 0.25-1.55 parts by weight is added in the water of 10-23 parts by weight, 80-90
Water-bath dissolution is carried out at DEG C；
2) acid regulator is added in step 1) solution, adjusting pH value of solution is 2-4, and 0.04-0.27 parts by weight are then added
The tannic acid of polyglutamic acid and 0.03-0.35 parts by weight, stirring is extremely dissolved at 25-45 DEG C；
3) mass concentration that 0.05-0.12 parts by weight are added is the glutaraldehyde of 2-10%, and after mixing evenly, ultrasound removes bubble removing,
It is applied in nano-silicon sheet mold, stands crosslinking 10-60min, obtain hydrogel；
4) hydrogel prepared is uniformly coated on non-woven fabrics, then covers polyethylene film above and obtains molding water-setting
Glue application.
2. a kind of preparation method of anti-dehydration gecko hydrogel application as described in claim 1, which is characterized in that including following
The raw material of parts by weight is made:
Polyvinyl alcohol 1.55；
Polyglutamic acid 0.15；
Tannic acid 0.22；
The glutaraldehyde 0.06 that mass concentration is 5%；
Water 20；
It the rest is acid regulator, the acid regulator is hydrochloric acid.
3. a kind of preparation method of anti-dehydration gecko hydrogel application as described in claim 1, it is characterised in that: the step
1) water-bath dissolution is carried out at 88 DEG C.
4. a kind of preparation method of anti-dehydration gecko hydrogel application as described in claim 1, it is characterised in that: the step
2) adjusting pH value of solution is 3.
5. a kind of preparation method of anti-dehydration gecko hydrogel application as claimed in claim 2, it is characterised in that: the step
2) stirring is extremely dissolved at 35 DEG C in.
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| CN201610692571.5A CN106267316B (en) | 2016-08-18 | 2016-08-18 | Anti- dehydration gecko hydrogel application of one kind and preparation method thereof |
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| CN107469129A (en) * | 2017-08-17 | 2017-12-15 | 太原理工大学 | A kind of antiseptic dressing and preparation method thereof |
| CN111150875B (en) * | 2020-02-13 | 2022-03-11 | 华中科技大学同济医学院附属协和医院 | Hydrogel for indwelling needle application and preparation method thereof |
| CN112933284A (en) * | 2021-02-07 | 2021-06-11 | 南京鼓楼医院 | Bionic patch for tissue adhesion and preparation method thereof |
| WO2022174713A1 (en) * | 2021-02-22 | 2022-08-25 | 中国长江三峡集团有限公司 | Self-fitting high-air-tightness mask having bionic gecko skin, and method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0613692A1 (en) * | 1993-03-03 | 1994-09-07 | JOHNSON & JOHNSON MEDICAL, INC. | Water soluble wound dressing materials |
| WO2013096605A1 (en) * | 2011-12-20 | 2013-06-27 | Bionova Medical, Inc. | Systems and methods for delivering an agent to a wound under negative pressure |
| CN103623457A (en) * | 2013-12-09 | 2014-03-12 | 长春吉原生物科技有限公司 | Special-shaped hydrogel functional dressing and preparation method thereof |
| CN105727369A (en) * | 2016-03-21 | 2016-07-06 | 中国科学院化学研究所 | Preparation method of gelatin/carbonated hydroxyapatite bone scaffold |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9512279B2 (en) * | 2013-12-18 | 2016-12-06 | Universite Cegy-Pontoise | Interpenetrating polymer network |
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- 2016-08-18 CN CN201610692571.5A patent/CN106267316B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0613692A1 (en) * | 1993-03-03 | 1994-09-07 | JOHNSON & JOHNSON MEDICAL, INC. | Water soluble wound dressing materials |
| WO2013096605A1 (en) * | 2011-12-20 | 2013-06-27 | Bionova Medical, Inc. | Systems and methods for delivering an agent to a wound under negative pressure |
| CN103623457A (en) * | 2013-12-09 | 2014-03-12 | 长春吉原生物科技有限公司 | Special-shaped hydrogel functional dressing and preparation method thereof |
| CN105727369A (en) * | 2016-03-21 | 2016-07-06 | 中国科学院化学研究所 | Preparation method of gelatin/carbonated hydroxyapatite bone scaffold |
Non-Patent Citations (1)
| Title |
|---|
| "Praparation of Tannin Based Hydrogel for Biological Application";Raheam Jameel Mhessn et al.;《Iranian Journal of Pharmaceutical Sciences Autumn》;20101231;第6卷(第4期);摘要，第264页右栏第3段 * |
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