CN104491918A - Novel antibacterial hydrocolloid dressing and preparation method thereof - Google Patents
Novel antibacterial hydrocolloid dressing and preparation method thereof Download PDFInfo
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- CN104491918A CN104491918A CN201510014405.5A CN201510014405A CN104491918A CN 104491918 A CN104491918 A CN 104491918A CN 201510014405 A CN201510014405 A CN 201510014405A CN 104491918 A CN104491918 A CN 104491918A
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Abstract
The invention relates to a novel antibacterial hydrocolloid dressing. The hydrocolloid dressing is characterized by comprising a backing layer, a hydrocolloid layer, an ozonization plant ointment layer and an anti-sticking layer from a lower layer to an upper layer; the weight ratio of the ingredients the hydrocolloid layer is preferably: a styrene polymer: polyisobutene 65,000 to polyisobutene 95,000 to white oil to croscarmellose sodium to M-shaped sodium carboxymethylcellulose= 30: 5: 15: 10: 16: 32; the anti-sticking layer is made from a PVC (Polyvinyl Chloride) or a release paper; the backing back is preferably made from non-woven fabrics, PVC+PU (Poly Urethane), PVC+PU+ PSA (Pressure-Sensitive Adhesive), the release paper+ PU+ PSA.
Description
Technical field
The present invention relates to a kind of novel antibacterial bearing hydrocolloid dressing and preparation method thereof, belong to medical dressing field.
Background technology
Medical dressing is used to the material of covering protection wound, mainly plays and controls wound fluid, protects wound from the pollution of extraneous antibacterial etc.Traditional medical dressing is by keeping the drying of wound, protection wound, until wound healing, but proposes " wet union is theoretical " from Winter, and the novel moisturizing new dressing-bearing hydrocolloid dressing that absorbs water has embodied obvious advantage.
Bearing hydrocolloid dressing is a kind of Medical dressing based on moist wounds healing theory, and it is generally mixed and processed by hydrophilic macromolecule granule and rubber elastomer, is mainly used in clinical healing property of difficulty wound.Bearing hydrocolloid dressing can be created moist healing environment, has the character of semipermeable membrane, have many-sided feature, is therefore subject to everybody high praise.
The main feature of hydrocolloid: (1) has the ability absorbing wound exudate.After absorbing sepage, the hydrophilic particle in dressing can form the semi-solid material of similar gels, is attached to wound base portion, provides and maintains the wet environment being conducive to wound healing; (2) there is viscosity, can closed environment be formed, the formation of microvascular hypertrophy and granulation tissue can be promoted, thus accelerate wound healing; (3) certain debridement function can be played.The closed environment that bearing hydrocolloid dressing provides, is conducive to macrophage and removes slough; (4) when changing dressings, adhesion wound, is convenient to nurse operation, alleviates wound pain, reduces dressing change frequency.
Bletilla glucomannan is through the heteropolysaccharide comprising Pseudobulbus Bletillae polysaccharose, bletilla mannan etc. that water extract-alcohol precipitation obtains from bletilla, have and promote the effect such as blood coagulation, antiinflammatory, therefore, Bletilla glucomannan can be added in the hydrocolloid formula of former invention, on the basis with the original advantage of hydrocolloid, there is effect that is antibacterial, hemostasis, thus for there being prevention that is hemorrhage, that infect or infect, compensate for the deficiency that original formulation is only suitable for being applied to general wound.
The present invention adopts uniform Design, carry out preferably to multiple auxiliary materials, water insoluble but that water absorption is very strong crosslinked CMC-Na is selected to be raw material, be prepared into hydrocolloid medical dressing, the transudate of this dressing Absorbable rod wound, and make wound be in wet environment, simultaneously, there are the adjuvants such as PU and external environment to completely cut off, avoid the intrusion of extraneous antibacterial.This novel bearing hydrocolloid dressing is also containing ozonisation plant ointment.Ozonisation plant ointment is the product that vegetable oil obtains through peroxone oxidation.Due to can occlusion ozone containing double bond in vegetable oil, thus ozone ointment be made to be provided with antibacterial, antiinflammation.Ozone ointment has the bactericidal action of wide spectrum and does not stay the corpse of any bacterial virus, it has the same function of hormone, antibiotic, but there is no hormone, antibiotic side effect and drug resistance, this is its radical cure difficult and complicated illness and the main cause that is easily accepted, is that it is better than the basic reason place of other treatment dressing.Ozone ointment is mainly used in wound, scald, acne, ulcer, radiotherapy skin ulcer, abscess, decubital ulcer, chronic ulcer, diabetic foot, burn, infected wound, candidiasis, tinea unguium, therefore, the present invention is by the product being rich in the peony seed oil of unsaturated fatty acid, Oleum Perillae, Oleum Helianthi, Semen Sesami wet goods vegetable oil obtain after peroxone oxidation, be applied on bearing hydrocolloid dressing, thus expand the scope of application of this hydrocolloid.
Summary of the invention
The object of the invention be to provide a kind of novel antibacterial, easy to use, be suitable for common wound, infected wound, wide material sources, safe and reliable medical dressing and preparation method thereof.
The present invention has filtered out the medical dressing with good water absorbing properties from multiple medical dressing, and optimal screening has gone out the optimum proportioning of various composition, and meanwhile, on hydrocolloid layer, coating has the ozonisation plant ointment of anti-inflammation, thus completes the present invention.
Therefore, the application provides following invention:
A kind of novel antibacterial bearing hydrocolloid dressing, is characterized in that described bearing hydrocolloid dressing comprises backing layer, hydrocolloid layer, ozonisation vegetable oil layer of paste and adherent layer successively from lower floor to upper strata; Backing layer, preferred non-woven fabrics, PVC+PU, PVC+PU+ pressure sensitive adhesive, release paper+PU, release paper+PU+ pressure sensitive adhesive; The composition that hydrocolloid layer comprises and weight ratio are: styrene polymer: polyisobutylene 6.5 ten thousand: polyisobutylene 9.5 ten thousand: white oil: cross-linking sodium carboxymethyl cellulose: M type sodium carboxymethyl cellulose=10-40: 0-10: 5-20: 4-20: 8-32: 15-64; Adherent layer is PVC or release paper.
Described hydrocolloid, is characterized in that the weight ratio optimization styrene polymer of each component: polyisobutylene 6.5 ten thousand: polyisobutylene 9.5 ten thousand: white oil: cross-linking sodium carboxymethyl cellulose: M type sodium carboxymethyl cellulose=30: 5: 15: 10: 16: 32;
Described hydrocolloid layer, its preparation method is:
A. by taking the styrene polymer of constant weight, polyisobutylene 6.5 ten thousand, polyisobutylene 9.5 ten thousand and white oil described in claim 1 respectively, under being placed in 160-170 DEG C of temperature, constantly stirring, making substrate homogeneous.
B. be added in uniform substrate by the M type sodium carboxymethyl cellulose (crossing 200 mesh sieves) and cross-linking sodium carboxymethyl cellulose that take constant weight described in claim 1 respectively, constantly stir, until mix homogeneously.
C. at such a temperature vacuum defoamation is carried out to the hydrocolloid of mix homogeneously, take out, coat the back of the body and claim, on material, to make it reach certain thickness.
Described hydrocolloid layer is except comprising styrene polymer, polyisobutylene 6.5 ten thousand, polyisobutylene 9.5 ten thousand, white oil, cross-linking sodium carboxymethyl cellulose, M type sodium carboxymethyl cellulose, also Bletilla glucomannan can be comprised, its weight ratio is Bletilla glucomannan: styrene polymer: polyisobutylene 6.5 ten thousand: polyisobutylene 9.5 ten thousand: white oil: cross-linking sodium carboxymethyl cellulose: M type sodium carboxymethyl cellulose=0-20: 10-40: 0-10: 5-20: 4-20: 8-32: 15-64, wherein preferably 5: 30: 5: 15: 10: 16: 32.
Described bearing hydrocolloid dressing, the area of coating ozonisation vegetable oil layer of paste is less than the hydrocolloid described in area of hydrocolloid layer, the preferred Oleum Perillae of vegetable oil, peony seed oil, the Oleum Helianthi of ozonisation plant ointment wherein.
Described ozonisation plant ointment, its preparation method is as follows: the vegetable oil of 50ml-100ml is placed in container, at 18-25 DEG C, ozone is passed into the speed of 5-10L/h, the generation of ozone is after 1-3g/h, 2-8 hour, makes the peroxide value of ozonisation vegetable oil reach 1000-2000, stop passing into ozone, namely obtain ozonisation plant ointment.
Vegetable oil in described ozonisation plant ointment, preferred Oleum Perillae, peony seed oil, Oleum Helianthi, Eucommia Oil.
Described bearing hydrocolloid dressing, is characterized in that may be used for medically absorbing wound fluid, promotes the healing of wound, isolation external environment prevents the extraneous antibacterial of wound infection, reduce the generation of cicatrix.
Described bearing hydrocolloid dressing, is characterized in that may be used for antibacterial, the antiinflammatory of wound, hemostasis.
Described bearing hydrocolloid dressing, it is characterized in that may be used for antibacterial, antiinflammatory, accelerating wound, cure the wound of difficult healing, absorbing wound exudate, is mainly used in wound, scald, acne, ulcer, radiotherapy skin ulcer, abscess, decubital ulcer, chronic ulcer, diabetic foot, burn, infected wound, candidiasis, tinea unguium.
Below by embodiment, the present invention is further described, but the present invention is not limited to the scope described in embodiment.
Detailed description of the invention
Embodiment 1.
By 1.5g styrene polymer, 0.5g polyisobutylene 6.5 ten thousand, 0.75g polyisobutylene 9.5 ten thousand and 0.5g white oil, be placed in container and be heated to 170 DEG C in oil bath, constantly stir, and after stirring 30min, makes substrate become even.Then 1.6gCMC-Na powder (crossing 200 mesh sieves) and 0.5g are cross-linked CMC-Na to be added in uniform substrate, constantly stir, mix about 15min and make substrate even.Under the prerequisite of insulation, after vacuum defoamation process 30min is carried out to the hydrocolloid of mix homogeneously, take out, coat 100cm
2the back of the body claims, on material, to make its thickness be 0.5mm.
Embodiment 2.
1g styrene polymer, 0.5g polyisobutylene 6.5 ten thousand, 0.75g polyisobutylene 9.5 ten thousand and 0.4g white oil, be placed in container and be heated to 170 DEG C in oil bath, constantly stir, and after stirring 30min, makes substrate become even.Then 0.8gCMC-Na powder (crossing 200 mesh sieves) and 1.5g are cross-linked CMC-Na to be added in uniform substrate, constantly stir, mix about 15min and make substrate even.Under the prerequisite of insulation, after vacuum defoamation process 30min is carried out to the hydrocolloid of mix homogeneously, take out, coat 100cm
2the back of the body claims, on material, to make its thickness be 0.5mm.
Embodiment 3.
1.2g styrene polymer, 0.5g polyisobutylene 6.5 ten thousand, 0.8g polyisobutylene 9.5 ten thousand and 0.5g white oil, be placed in container and be heated to 170 DEG C in oil bath, constantly stir, and after stirring 30min, makes substrate become even.Then 0.8gCMC-Na powder (crossing 200 mesh sieves) and 1.6g are cross-linked CMC-Na to be added in uniform substrate, constantly stir, mix about 15min and make substrate even.Under the prerequisite of insulation, after vacuum defoamation process 30min is carried out to the hydrocolloid of mix homogeneously, take out, coat 100cm
2the back of the body claims, on material, to make its thickness be 0.5mm.
Embodiment 4.
1.2g styrene polymer, 0.5g polyisobutylene 6.5 ten thousand, 0.5g polyisobutylene 9.5 ten thousand and 0.4g white oil, be placed in container and be heated to 170 DEG C in oil bath, constantly stir, and after stirring 30min, makes substrate become even.Then 0.8gCMC-Na powder (crossing 200 mesh sieves) and 1.5g are cross-linked CMC-Na to be added in uniform substrate, constantly stir, mix about 15min and make substrate even.Under the prerequisite of insulation, after vacuum defoamation process 30min is carried out to the hydrocolloid of mix homogeneously, take out, coat 100cm
2the back of the body claims, on material, to make its thickness be 0.5mm.
Embodiment 5.
1g styrene polymer, 0.5g polyisobutylene 6.5 ten thousand, 0.5g polyisobutylene 9.5 ten thousand and 0.7g white oil, be placed in container and be heated to 170 DEG C in oil bath, constantly stir, and after stirring 30min, makes substrate become even.Then 0.8gCMC-Na powder (crossing 200 mesh sieves) and 1.5g are cross-linked CMC-Na to be added in uniform substrate, constantly stir, mix about 15min and make substrate even.Under the prerequisite of insulation, after vacuum defoamation process 30min is carried out to the hydrocolloid of mix homogeneously, take out, coat 100cm
2the back of the body claims, on material, to make its thickness be 0.5mm.
Embodiment 6.
1.5g styrene polymer, 0.7g polyisobutylene 6.5 ten thousand, 0.7g polyisobutylene 9.5 ten thousand and 0.6g white oil, be placed in container and be heated to 170 DEG C in oil bath, constantly stir, and after stirring 30min, makes substrate become even.Then 0.8gCMC-Na powder (crossing 200 mesh sieves) and 2g are cross-linked CMC-Na to be added in uniform substrate, constantly stir, mix about 15min and make substrate even.Under the prerequisite of insulation, after vacuum defoamation process 30min is carried out to the hydrocolloid of mix homogeneously, take out, coat 100cm
2the back of the body claims, on material, to make its thickness be 0.5mm.
The mensuration of embodiment 7. initial bonding strength
Prepare the slope board of 30 degree, clean hang plate and stainless steel ball surface.Upwards be fixed on hang plate between two graduation marks with double faced adhesive tape by bearing hydrocolloid dressing adhesive faces, the laminating that test sample should be smooth onboard.With tweezers, steel ball is placed in start line, before formal test, a test sample allows repeatedly to test, but should regulate the right position of steel ball, and the track making it roll does not overlap.Whether preliminary election is big steel ball comparatively, observe the steel ball that rolls down and can be sticked (stopping is moved beyond 5s) in test section, and from big to small, the steel ball getting different ball number carries out the test of suitable number of times, until find test section can by the maximum steel ball sticked.Get aforementioned by the steel ball of maximum number that sticks and two balls of its ball number adjacent size, same test sample respectively can being carried out a test, to confirm maximum steel ball ball number.Initial bonding strength the results are shown in Table 1.
Embodiment 8. water absorption rate measures
The preparation of experimental liquid: this solution is by the solution composition of sodium chloride and calcium chloride, and this solution is the calcium ion containing 142mmol sodium ion and 2.5mmol.The ion concentration of this solution is equivalent to human serum or wound fluid.100ml is diluted to deionized water dissolving 0.8298g sodium chloride and 0.0278g anhydrous calcium chloride in volumetric flask.
Water absorption rate measures: cut-off footpath is the sample cell of 2cm, adds the experimental liquid that certain volume prepares.According to the size of bore, the bearing hydrocolloid dressing of the certain area of clip, weighed weight (W
1), be affixed on sample cell Chi Kou, with seal cap sealing, be inverted, be placed in climatic chamber, temperature is 37 DEG C, takes out after 24h, is taken off by hydrocolloid, when it does not drip, and weighed weight, record data (W
2).The calculating of water absorption rate: water absorption rate=(W
2-W
1)/W
1(%), the results are shown in Table 1.
The bearing hydrocolloid dressing performance of the various different embodiment of table 1.
Embodiment 9.
The vegetable oil of 50ml is placed in 100ml container, at 25 DEG C, ozone is passed into the speed of 10L/h, the generation of ozone is 1g/h, after 4 hours, makes the peroxide value of ozonisation vegetable oil reach 1500, stop passing into ozone, namely obtain ozonisation plant ointment, coated above hydrocolloid layer, cover adherent layer and namely obtain bearing hydrocolloid dressing.
Embodiment 10.
The vegetable oil of 100ml is placed in 100ml container, at 18 DEG C, ozone is passed into the speed of 5L/h, the generation of ozone is 1g/h, after 8 hours, makes the peroxide value of ozonisation vegetable oil reach 2000, stop passing into ozone, namely obtain ozonisation plant ointment, coated above hydrocolloid layer, cover adherent layer and namely obtain bearing hydrocolloid dressing.
Claims (10)
1. a novel antibacterial bearing hydrocolloid dressing, is characterized in that described bearing hydrocolloid dressing comprises backing layer, hydrocolloid layer, ozonisation vegetable oil layer of paste and adherent layer successively from lower floor to upper strata; Backing layer, preferred non-woven fabrics, PVC+PU, PVC+PU+ pressure sensitive adhesive, release paper+PU, release paper+PU+ pressure sensitive adhesive; The composition that hydrocolloid layer comprises and weight ratio are: styrene polymer: polyisobutylene 6.5 ten thousand: polyisobutylene 9.5 ten thousand: white oil: cross-linking sodium carboxymethyl cellulose: M type sodium carboxymethyl cellulose=10-40: 0-10: 5-20: 4-20: 8-32: 15-64; Adherent layer is PVC or release paper.
2. the hydrocolloid layer described in claim 1, is characterized in that the weight ratio optimization styrene polymer of each component: polyisobutylene 6.5 ten thousand: polyisobutylene 9.5 ten thousand: white oil: cross-linking sodium carboxymethyl cellulose: M type sodium carboxymethyl cellulose=30: 5: 15: 10: 16: 32.
3. the hydrocolloid layer described in claim 1, its preparation method is:
A. by taking the styrene polymer of constant weight, polyisobutylene 6.5 ten thousand, polyisobutylene 9.5 ten thousand and white oil described in claim 1 respectively, at being placed in 160-170 DEG C, constantly mix homogeneously is stirred to.
B. be added in uniform substrate by the M type sodium carboxymethyl cellulose (crossing 200 mesh sieves) and cross-linking sodium carboxymethyl cellulose that take constant weight described in claim 1 respectively, be constantly stirred to mix homogeneously.
C. at 160-170 DEG C, vacuum defoamation is carried out to the mixture of mix homogeneously, coat the back of the body and claim, on layer, to make it reach certain thickness.
4. the hydrocolloid layer described in claim 1 is except comprising styrene polymer, polyisobutylene 6.5 ten thousand, polyisobutylene 9.5 ten thousand, white oil, cross-linking sodium carboxymethyl cellulose, M type sodium carboxymethyl cellulose, also Bletilla glucomannan can be comprised, its weight ratio is Bletilla glucomannan: styrene polymer: polyisobutylene 6.5 ten thousand: polyisobutylene 9.5 ten thousand: white oil: cross-linking sodium carboxymethyl cellulose: M type sodium carboxymethyl cellulose=0-20: 10-40: 0-10: 5-20: 4-20: 8-32: 15-64, wherein preferably 5: 30: 5: 15: 10: 16: 32.
5. bearing hydrocolloid dressing according to claim 1, the area of coating ozonisation vegetable oil layer of paste is less than the area of hydrocolloid layer.
6. ozonisation plant ointment according to claim 1, its preparation method is as follows:
The vegetable oil of 50ml-100ml is placed in container, at 18-25 DEG C, passes into ozone with the speed of 5-10L/h, the generation of ozone is after 1-3g/h, 2-8 hour, makes the peroxide value of ozonisation vegetable oil reach 1000-2000, stop passing into ozone, namely obtain ozonisation plant ointment.
7. the vegetable oil in the ozonisation plant ointment described in claim 6, preferred Oleum Perillae, peony seed oil, Oleum Helianthi, Eucommia Oil.
8. the bearing hydrocolloid dressing described in claim 1, is characterized in that may be used for medically absorbing wound fluid, promotes the healing of wound, isolation external environment prevents the extraneous antibacterial of wound infection, reduce the generation of cicatrix.
9. the bearing hydrocolloid dressing described in claim 4, is characterized in that may be used for antibacterial, the antiinflammatory of wound, hemostasis.
10. the bearing hydrocolloid dressing described in claim 1, it is characterized in that may be used for antibacterial, antiinflammatory, accelerating wound, cure the wound of difficult healing, absorbing wound exudate, is mainly used in wound, scald, acne, ulcer, radiotherapy skin peptide ulcer, abscess, decubital ulcer, chronic ulcer, diabetic foot, burn, infected wound, candidiasis, tinea unguium.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105031709A (en) * | 2015-08-28 | 2015-11-11 | 重庆医科大学附属永川医院 | Medical hydrocolloid dressing and preparation method |
| CN105688252A (en) * | 2016-03-18 | 2016-06-22 | 苏州健宇医疗科技有限公司 | Medical vaseline ointment gauze and manufacturing method thereof |
| ITUB20160291A1 (en) * | 2016-02-01 | 2017-08-01 | Oxidea Soc A Responsabilita Limitata Semplificata | PREPARATION FOR RESTRICTIVE USE FOR MEDICAL USE, AND SPECIAL USE OF SUCH PREPARATION |
| CN107802640A (en) * | 2017-11-01 | 2018-03-16 | 湖南源绿科技有限公司 | A kind of preparation method of nanoemulsions ozone oil |
| CN108030900A (en) * | 2017-11-01 | 2018-05-15 | 湖南源绿科技有限公司 | A kind of composite ozone carburetion for treating onychomycosis |
| CN108310444A (en) * | 2018-05-04 | 2018-07-24 | 中南大学湘雅三医院 | A kind of preparation method of medical ozone ointment dressing patch |
| CN108403713A (en) * | 2018-06-12 | 2018-08-17 | 南方医科大学南方医院 | A kind of ozone fluid composition, preparation method and gauze for promoting chronic wound care |
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- 2015-01-07 CN CN201510014405.5A patent/CN104491918A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105031709A (en) * | 2015-08-28 | 2015-11-11 | 重庆医科大学附属永川医院 | Medical hydrocolloid dressing and preparation method |
| CN105031709B (en) * | 2015-08-28 | 2017-12-15 | 重庆医科大学附属永川医院 | A kind of preparation method of medical use hydrocolloid dressing |
| ITUB20160291A1 (en) * | 2016-02-01 | 2017-08-01 | Oxidea Soc A Responsabilita Limitata Semplificata | PREPARATION FOR RESTRICTIVE USE FOR MEDICAL USE, AND SPECIAL USE OF SUCH PREPARATION |
| WO2017134573A1 (en) * | 2016-02-01 | 2017-08-10 | Oxidea Societa' A Responsabilita' Limitata Semplificata | Resorbable preparation for medical applications, and characteristic uses for said preparation |
| CN105688252A (en) * | 2016-03-18 | 2016-06-22 | 苏州健宇医疗科技有限公司 | Medical vaseline ointment gauze and manufacturing method thereof |
| CN107802640A (en) * | 2017-11-01 | 2018-03-16 | 湖南源绿科技有限公司 | A kind of preparation method of nanoemulsions ozone oil |
| CN108030900A (en) * | 2017-11-01 | 2018-05-15 | 湖南源绿科技有限公司 | A kind of composite ozone carburetion for treating onychomycosis |
| CN108310444A (en) * | 2018-05-04 | 2018-07-24 | 中南大学湘雅三医院 | A kind of preparation method of medical ozone ointment dressing patch |
| CN108403713A (en) * | 2018-06-12 | 2018-08-17 | 南方医科大学南方医院 | A kind of ozone fluid composition, preparation method and gauze for promoting chronic wound care |
| CN108403713B (en) * | 2018-06-12 | 2021-07-16 | 南方医科大学南方医院 | Ozone oil composition for promoting chronic wound healing, preparation method and gauze |
| CN112354006A (en) * | 2020-11-25 | 2021-02-12 | 周建大 | Preparation method of acellular amniotic membrane hydrogel dressing added with ozone oil |
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Application publication date: 20150408 |