CN105079860A - Air-permeable moisturizing dressing with bacteriostasis and drug percutaneous absorption promotion functions and preparation method of air-permeable moisturizing dressing - Google Patents
Air-permeable moisturizing dressing with bacteriostasis and drug percutaneous absorption promotion functions and preparation method of air-permeable moisturizing dressing Download PDFInfo
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Abstract
The invention discloses an air-permeable moisturizing dressing with bacteriostasis and drug percutaneous absorption promotion functions and a preparation method of the air-permeable moisturizing dressing. The air-permeable moisturizing dressing comprises the following raw materials in parts by weight: 12-14 parts of N-trimethyl chitosan, 8-12 parts of menthanol, 5-7 parts of isopropyl myristate, 20-30 parts of chitosan, 25-35 parts of loofah sponge fibers, 8-14 parts of isomalto-oligosaccharide, 5-9 parts of polyvinyl alcohol, 6-10 parts of carboxymethyl cellulose sodium, 10-12 parts of glycerol, 8-10 parts of mannitol, 12-20 parts of medicinal powder, 3-7 parts of weak-acid calcium chloride and a proper amount of deionized water. As chitosan and loofah sponge fibers are combined together, the moisturizing property of the dressing is guaranteed by adsorbability of chitosan, and the air permeability of the dressing is guaranteed by the hollow tube bundle structures of the loofah sponge fibers; meanwhile, chitosan derivatives are used together to effectively promote percutaneous absorption and wound healing, so that a favorable effect is achieved.
Description
Technical field
The invention belongs to biological medicine Material Field, specifically relate to a kind of air permeable humidity retaining dressing and the preparation method with antibacterial promotion Drug Percutaneous Absorption.
Background technology
Chitosan-phospholipid complex can promote the healing of epithelial growth and wound.Chitosan can be absorbed by normal skin histology, but injured skin histology reduces greatly to its absorbability.Research shows, liposoluble substance and the little material of molecular mass are easily absorbed by the body.Therefore for wounded tissue, select low-molecular-weight chitosan to prepare medical dressing and be necessary.Chitosan is prepared into dressing and is used for the treatment of wound surface, the research of this respect is many, but chitosan dressing in the market also exists and easily occurs and wound surface adhesion, moisture-penetrable ventilated property is little, healing cycle is long, the unfavorable conditions such as hamartoplasia, haemostatic effect are undesirable, cause postoperative care cycle of a specified duration, the defects such as nursing procedure is many.
The cancellated natural vascular tissue of the cellulosic that loofah fiber obtains after being to provide crust and seed, there is good breathability and degradability, there is the effect of removing obstruction in the collateral to relieve pain, expelling wind and activating blood circulation, blood fat reducing, prevention ischemia myocardial damage and antalgic and inflammation relieving simultaneously.
Summary of the invention
For the growth requirement of biological medicine material, the invention provides a kind of air permeable humidity retaining dressing and the preparation method with antibacterial promotion Drug Percutaneous Absorption.
For achieving the above object, the technical solution used in the present invention is:
Have an air permeable humidity retaining dressing for antibacterial promotion Drug Percutaneous Absorption, said composition comprises the raw material by following weight portion: N-N-trimethyl chitosan TMC 12-14, menthol 8-12, isopropyl myristate 5-7, chitosan 20-30, loofah fiber 25-35, oligomeric isomaltose 8-14, polyvinyl alcohol 5-9, Carboxymethyl cellulose sodium 6-10, glycerol 10-12, mannitol 8-10, medicated powder 12-20, faintly acid calcium chloride 3-7, appropriate deionized water.
There is a preparation method for the air permeable humidity retaining dressing of antibacterial promotion Drug Percutaneous Absorption, comprise the following steps:
(1) get loofah fiber and 9-11 deionized water mixing doubly, and stir 10h with the speed of 250r/min in 75 DEG C of waters bath with thermostatic control, use 16 layers of filtered through gauze afterwards, obtain loofah fiber lixiviating solution for subsequent use;
(2) chitosan, the mixing of acid chlorization calcium is got, and add gross weight 3-5 deionized water doubly, 3-5h is stirred with 150r/min at 60 DEG C, in the process stirred, slowly add N-N-trimethyl chitosan TMC, menthol, isopropyl myristate, oligomeric isomaltose successively, and continue stirring until and be uniformly dissolved, it is for subsequent use that 16 layers of filtered through gauze obtains evenly short Transdermal absorption liquid;
(3) medicated powder is added evenly urging in Transdermal absorption liquid, with 100r/min mixing and stirring, adding polyvinyl alcohol, Carboxymethyl cellulose sodium, mannitol, loofah fiber lixiviating solution afterwards, put into high pressure homogenizer homogenizing 30-50min, it is for subsequent use that standing and defoaming 1-2h obtains complex liquid;
(4) complex liquid is adopted traditional vacuum evaporation, deviating from moisture to content at 15 DEG C is gross weight 20-30%, add glycerol, stir 2-3h to even, continue to adopt traditional vacuum evaporation to remove moisture ad pond om 10-12% at 15 DEG C, naturally dry 12-24h, be pressed into the cream of 1-2mm and get final product.
Beneficial effect of the present invention:
The present invention adopts chitosan to be combined with each other in conjunction with loofah fiber, the adsorptivity of chitosan is utilized to ensure that the humidity-preserving type of dressing, the hollow Pipe bundle structure of loofah fiber is utilized to ensure that the breathability of dressing, simultaneously in conjunction with chitosan derivatives, effective promotion Transdermal absorption, promote wound healing, play good effect.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
Embodiment 1:
Have an air permeable humidity retaining dressing for antibacterial promotion Drug Percutaneous Absorption, said composition comprises the raw material by following weight portion: N-N-trimethyl chitosan TMC 12, menthol 8, isopropyl myristate 5, chitosan 20, loofah fiber 35, oligomeric isomaltose 8, polyvinyl alcohol 5, Carboxymethyl cellulose sodium 6, glycerol 10, mannitol 8, medicated powder 12, faintly acid calcium chloride 3, appropriate deionized water.
There is a preparation method for the air permeable humidity retaining dressing of antibacterial promotion Drug Percutaneous Absorption, comprise the following steps:
(1) get the deionized water mixing of loofah fiber and 10 times, and stir 10h with the speed of 250r/min in 75 DEG C of waters bath with thermostatic control, use 16 layers of filtered through gauze afterwards, obtain loofah fiber lixiviating solution for subsequent use;
(2) chitosan, the mixing of acid chlorization calcium is got, and add the deionized water of gross weight 4 times, 4h is stirred with 150r/min at 60 DEG C, in the process stirred, slowly add N-N-trimethyl chitosan TMC, menthol, isopropyl myristate, oligomeric isomaltose successively, and continue stirring until and be uniformly dissolved, it is for subsequent use that 16 layers of filtered through gauze obtains evenly short Transdermal absorption liquid;
(3) medicated powder is added evenly urging in Transdermal absorption liquid, with 100r/min mixing and stirring, adding polyvinyl alcohol, Carboxymethyl cellulose sodium, mannitol, loofah fiber lixiviating solution afterwards, put into high pressure homogenizer homogenizing 40min, it is for subsequent use that standing and defoaming 1.5h obtains complex liquid;
(4) complex liquid is adopted traditional vacuum evaporation, deviating from moisture to content at 15 DEG C is gross weight 20, %, add glycerol, stir 3h to evenly, continue to adopt traditional vacuum evaporation to remove moisture ad pond om 10% at 15 DEG C, naturally dry 12h, be pressed into the cream of 1mm and get final product.
Embodiment 2:
Have an air permeable humidity retaining dressing for antibacterial promotion Drug Percutaneous Absorption, said composition comprises the raw material by following weight portion: N-N-trimethyl chitosan TMC 13, menthol 10, isopropyl myristate 6, chitosan 25, loofah fiber 30, oligomeric isomaltose 11, polyvinyl alcohol 7, Carboxymethyl cellulose sodium 8, glycerol 11, mannitol 9, medicated powder 16, faintly acid calcium chloride 5, appropriate deionized water.
There is a preparation method for the air permeable humidity retaining dressing of antibacterial promotion Drug Percutaneous Absorption, comprise the following steps:
(1) get the deionized water mixing of loofah fiber and 10 times, and stir 10h with the speed of 250r/min in 75 DEG C of waters bath with thermostatic control, use 16 layers of filtered through gauze afterwards, obtain loofah fiber lixiviating solution for subsequent use;
(2) chitosan, the mixing of acid chlorization calcium is got, and add the deionized water of gross weight 4 times, 4h is stirred with 150r/min at 60 DEG C, in the process stirred, slowly add N-N-trimethyl chitosan TMC, menthol, isopropyl myristate, oligomeric isomaltose successively, and continue stirring until and be uniformly dissolved, it is for subsequent use that 16 layers of filtered through gauze obtains evenly short Transdermal absorption liquid;
(3) medicated powder is added evenly urging in Transdermal absorption liquid, with 100r/min mixing and stirring, adding polyvinyl alcohol, Carboxymethyl cellulose sodium, mannitol, loofah fiber lixiviating solution afterwards, put into high pressure homogenizer homogenizing 40min, it is for subsequent use that standing and defoaming 1.5h obtains complex liquid;
(4) complex liquid is adopted traditional vacuum evaporation, deviating from moisture to content at 15 DEG C is gross weight 25%, adds glycerol, stir 2.5h to even, continue to adopt traditional vacuum evaporation to remove moisture ad pond om 11% at 15 DEG C, naturally dry 18h, be pressed into the cream of 1.5mm and get final product.
Embodiment 3:
Have an air permeable humidity retaining dressing for antibacterial promotion Drug Percutaneous Absorption, said composition comprises the raw material by following weight portion: N-N-trimethyl chitosan TMC 14, menthol 12, isopropyl myristate 7, chitosan 30, loofah fiber 25, oligomeric isomaltose 14, polyvinyl alcohol 9, Carboxymethyl cellulose sodium 10, glycerol 12, mannitol 10, medicated powder 20, faintly acid calcium chloride 7, appropriate deionized water.
There is a preparation method for the air permeable humidity retaining dressing of antibacterial promotion Drug Percutaneous Absorption, comprise the following steps:
(1) get the deionized water mixing of loofah fiber and 10 times, and stir 10h with the speed of 250r/min in 75 DEG C of waters bath with thermostatic control, use 16 layers of filtered through gauze afterwards, obtain loofah fiber lixiviating solution for subsequent use;
(2) chitosan, the mixing of acid chlorization calcium is got, and add the deionized water of gross weight 4 times, 4h is stirred with 150r/min at 60 DEG C, in the process stirred, slowly add N-N-trimethyl chitosan TMC, menthol, isopropyl myristate, oligomeric isomaltose successively, and continue stirring until and be uniformly dissolved, it is for subsequent use that 16 layers of filtered through gauze obtains evenly short Transdermal absorption liquid;
(3) medicated powder is added evenly urging in Transdermal absorption liquid, with 100r/min mixing and stirring, adding polyvinyl alcohol, Carboxymethyl cellulose sodium, mannitol, loofah fiber lixiviating solution afterwards, put into high pressure homogenizer homogenizing 40min, it is for subsequent use that standing and defoaming 1.5h obtains complex liquid;
(4) complex liquid is adopted traditional vacuum evaporation, deviating from moisture to content at 15 DEG C is gross weight 30%, adds glycerol, stir 2h to even, continue to adopt traditional vacuum evaporation to remove moisture ad pond om 12% at 15 DEG C, naturally dry 24h, be pressed into the cream of 2mm and get final product.
For the identical mouselet of four leg injury, adopt the existing dressing of dressing and market that above-described embodiment 1-3 is obtained respectively, observed result is as shown in table 1:
The experimental result of the mouselet of the dressing that table 1 embodiment 1-3 obtains and existing dressing treatment leg injury
As seen from the above table, dressing of the present invention is compared to existing dressing on market can promote Transdermal absorption, promotes the healing of wound, reduce the sticky of dressing and wound surface, reduce counter productive, better retain in order to drug effect and promote wound healing, thickness is empress dowager not easily, also not easily too thin.
Claims (2)
1. one kind has the air permeable humidity retaining dressing of antibacterial promotion Drug Percutaneous Absorption, it is characterized in that, said composition comprises the raw material by following weight portion: N-N-trimethyl chitosan TMC 12-14, menthol 8-12, isopropyl myristate 5-7, chitosan 20-30, loofah fiber 25-35, oligomeric isomaltose 8-14, polyvinyl alcohol 5-9, Carboxymethyl cellulose sodium 6-10, glycerol 10-12, mannitol 8-10, medicated powder 12-20, faintly acid calcium chloride 3-7, appropriate deionized water.
2. there is a preparation method for the air permeable humidity retaining dressing of antibacterial promotion Drug Percutaneous Absorption as claimed in claim 1, it is characterized in that, comprise the following steps:
(1) get loofah fiber and 9-11 deionized water mixing doubly, and stir 10h with the speed of 250r/min in 75 DEG C of waters bath with thermostatic control, use 16 layers of filtered through gauze afterwards, obtain loofah fiber lixiviating solution for subsequent use;
(2) chitosan, the mixing of acid chlorization calcium is got, and add gross weight 3-5 deionized water doubly, 3-5h is stirred with 150r/min at 60 DEG C, in the process stirred, slowly add N-N-trimethyl chitosan TMC, menthol, isopropyl myristate, oligomeric isomaltose successively, and continue stirring until and be uniformly dissolved, it is for subsequent use that 16 layers of filtered through gauze obtains evenly short Transdermal absorption liquid;
(3) medicated powder is added evenly urging in Transdermal absorption liquid, with 100r/min mixing and stirring, adding polyvinyl alcohol, Carboxymethyl cellulose sodium, mannitol, loofah fiber lixiviating solution afterwards, put into high pressure homogenizer homogenizing 30-50min, it is for subsequent use that standing and defoaming 1-2h obtains complex liquid;
(4) complex liquid is adopted traditional vacuum evaporation, deviating from moisture to content at 15 DEG C is gross weight 20-30%, add glycerol, stir 2-3h to even, continue to adopt traditional vacuum evaporation to remove moisture ad pond om 10-12% at 15 DEG C, naturally dry 12-24h, be pressed into the cream of 1-2mm and get final product.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107137752A (en) * | 2016-03-01 | 2017-09-08 | 南京理工大学 | A kind of preparation method of luffa resist blocking and that Wound dressing |
| CN108187120A (en) * | 2018-02-06 | 2018-06-22 | 重庆医科大学附属永川医院 | A kind of medical analgesic hemostatic dressing of department of anesthesia and preparation method thereof |
| CN108339184A (en) * | 2018-02-12 | 2018-07-31 | 重庆医科大学附属永川医院 | A kind of anesthesia dressing packet and preparation method thereof for skin surface |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101342382A (en) * | 2008-04-17 | 2009-01-14 | 王海霞 | Pure natural medical dressings |
| CN103083713A (en) * | 2012-12-10 | 2013-05-08 | 江苏华亿细胞组织工程有限公司 | Sterile polymerized covering dressing for wound surface |
| WO2013167098A2 (en) * | 2012-05-11 | 2013-11-14 | Contipro Biotech S.R.O. | Method of preparation of polysaccharide fibers, wound covers that contain them, method of manufacturing of wound covers, and apparatus for preparation of polysaccharide fibers |
| CN104623719A (en) * | 2015-02-03 | 2015-05-20 | 广东泰宝医疗科技股份有限公司 | Chitosan hydrogel dressing and preparation method of chitosan hydrogel dressing |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101342382A (en) * | 2008-04-17 | 2009-01-14 | 王海霞 | Pure natural medical dressings |
| WO2013167098A2 (en) * | 2012-05-11 | 2013-11-14 | Contipro Biotech S.R.O. | Method of preparation of polysaccharide fibers, wound covers that contain them, method of manufacturing of wound covers, and apparatus for preparation of polysaccharide fibers |
| CN103083713A (en) * | 2012-12-10 | 2013-05-08 | 江苏华亿细胞组织工程有限公司 | Sterile polymerized covering dressing for wound surface |
| CN104623719A (en) * | 2015-02-03 | 2015-05-20 | 广东泰宝医疗科技股份有限公司 | Chitosan hydrogel dressing and preparation method of chitosan hydrogel dressing |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107137752A (en) * | 2016-03-01 | 2017-09-08 | 南京理工大学 | A kind of preparation method of luffa resist blocking and that Wound dressing |
| CN107137752B (en) * | 2016-03-01 | 2020-06-19 | 南京理工大学 | Preparation method of loofah sponge anti-adhesion wound dressing |
| CN108187120A (en) * | 2018-02-06 | 2018-06-22 | 重庆医科大学附属永川医院 | A kind of medical analgesic hemostatic dressing of department of anesthesia and preparation method thereof |
| CN108187120B (en) * | 2018-02-06 | 2021-04-09 | 重庆医科大学附属永川医院 | Anesthesia department medical pain-relieving and bleeding-stopping dressing and preparation method thereof |
| CN108339184A (en) * | 2018-02-12 | 2018-07-31 | 重庆医科大学附属永川医院 | A kind of anesthesia dressing packet and preparation method thereof for skin surface |
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Effective date of registration: 20180817 Address after: 225000 Hangzhou City, Jiangsu, Yangzhou Applicant after: Yangzhou tourist daily necessities manufacturing General Factory Address before: 528000 two, 920, two, 1, five, Ji Hua six road, Chancheng District, Foshan, Guangdong Province, two, two Applicant before: Foshan Lan Tu Science and Technology Ltd. |
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