CN107126540A - A kind of hemostatic and antibacterial ointment, medicine and preparation method thereof - Google Patents
A kind of hemostatic and antibacterial ointment, medicine and preparation method thereof Download PDFInfo
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- CN107126540A CN107126540A CN201710307991.1A CN201710307991A CN107126540A CN 107126540 A CN107126540 A CN 107126540A CN 201710307991 A CN201710307991 A CN 201710307991A CN 107126540 A CN107126540 A CN 107126540A
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- ointment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
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- A61F13/00—Bandages or dressings; Absorbent pads
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- A61F13/00—Bandages or dressings; Absorbent pads
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
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Abstract
The present invention relates to a kind of hemostatic and antibacterial ointment, medicine and preparation method thereof, each traditional Chinese medicine ingredients compatibility is reasonable, traditional Chinese medicine powder is especially made public for the first time to mix with extract, and the combination based on nanoscale traditional Chinese medicine powder and extract, the problem of advantage for playing respective Chinese medicine also solves respective influence；Mixing traditional Chinese medicine powder and extract solution at low temperature, it is to avoid reaction from each other, it also avoid the loss of drug effect, the ointment of preparation is maintained at low temperature, take out when in use, with reference to the effect of through hole, graphene and body temperature, the quick backheat of ointment can be caused and played a role.The present invention can prepare medical ointment plaster due to each composition of reasonable compatibility using hemostatic and antibacterial ointment and mop, so as to effectively suppress because of ointment with contact human skin and exposed to the extraneous issuable bacterium of institute.
Description
Technical field
The present invention relates to a kind of hemostatic and antibacterial ointment, medicine and preparation method thereof.
Background technology
In modern society, because of daily severe traffic injury, wartime firearm injury, the attack of terrorism, rescue and relief work, tissue device
The wound caused by natural calamity such as official's damage and operation and landslide, typhoon, earthquake, mud-rock flow happens occasionally, and it is outer to stop blooding
Wound, the important step of war wound emergency treatment, Wound dressing are divided into traditional dressing, biological dressing and synthetic dressing according to its material composition
Deng.Traditional ointment patch generally includes ointment and Tobe in addition, and user is in use, it will usually paste 24 hours,
Within this 24 hours, if poor air permeability, Bacteria suppression ability, it will bring secondary injury to user.
The content of the invention
It is an object of the invention to provide a kind of hemostatic and antibacterial ointment, medicine and preparation method thereof.
To achieve these goals, the present invention uses following technical scheme：A kind of preparation method of hemostatic and antibacterial ointment, bag
Include following steps：
(1) added after being respectively washed pseudo-ginseng, the fruit of medicinal cornel, polygala, the capsule of weeping forsythia, aloe, turmeric, Sophora alopecuroide and 30 points are soaked in pure water
Clock, bath raio 1: 25；Then take out the pseudo-ginseng cleaned by microwave drying, the fruit of medicinal cornel, polygala, the capsule of weeping forsythia, aloe, turmeric, bitter beans
Son；Then using water as extract solution, respectively to pseudo-ginseng, the fruit of medicinal cornel, polygala, the capsule of weeping forsythia carry out water extraction process obtain pseudo-ginseng aqueous extract,
Fruit of medicinal cornel aqueous extract, polygala aqueous extract, capsule of weeping forsythia aqueous extract；Using ethanol as extract solution, second is carried out to turmeric, Sophora alopecuroide respectively
Alcohol extracting processing obtains turmeric ethanol extract, Sophora alopecuroide ethanol extract；With pseudo-ginseng aqueous extract and turmeric ethanol extract
Mixed liquor aloe is carried out to extract and obtain pseudo-ginseng/turmeric/extract solution from aloe；Then fruit of medicinal cornel aqueous extract, polygala water are extracted
Liquid, capsule of weeping forsythia aqueous extract, Sophora alopecuroide ethanol extract, pseudo-ginseng/turmeric/extract solution from aloe are in mixing, ultrasonically treated 6 points under normal temperature
Clock；The Chinese medical extract that solid content is 60% is concentrated to give for the first time；The pseudo-ginseng, the fruit of medicinal cornel, polygala, the capsule of weeping forsythia, aloe, turmeric,
The mass ratio of Sophora alopecuroide is 100: 78: 54: 19: 11: 16: 23；
(2) add in pure water and soak 30 minutes together after being respectively washed matrimony vine, mulberry leaf, clinopodium polycephalum, garden burnet, frankincense, bath
Than 1: 30；Then carry out broken wall treatment to handle with ultrasonically treated, press filtration, obtain mixed solution；Concentration after mixed solution concentration
Thing obtains traditional Chinese medicine powder by hypergravity processing, freeze-drying, irradiation sterilization；The matrimony vine, mulberry leaf, clinopodium polycephalum, garden burnet, frankincense
Mass ratio is 100: 78: 11: 24: 22；
Under (3) 5 degree, traditional Chinese medicine powder, hydroxyapatite are added in Chinese medical extract, ultrasonic disperse 3 hours is added bright
Glue；Concentrated by second, obtain hemostatic and antibacterial ointment；The traditional Chinese medicine powder, hydroxyapatite, gelatin, the matter of Chinese medical extract
Amount is than being 38: 6: 12: 100, being uniformly dispersed beneficial to each composition in mixing, so that when concentrating for second, Nano Chinese medicine powder
Be not in the defects such as local cluster, the performance for plaster curative effect provides good basis.
In above-mentioned technical proposal, in step (1), the technique of the water extraction process is, boiling water pan feeding, then in 0.3MPa
Handled under pressure 10 minutes, then atmospheric pressure reflux processing 15 minutes, natural cooling completes water extraction process；At the ethanol extraction
The technique of reason is that then normal temperature pan feeding adjusts temperature for reflux temperature, handle 20 minutes, natural cooling completes ethanol in 1 minute
Extraction process；The technique extracted to aloe is that then normal temperature batch mixing adjusts temperature for reflux temperature in 15 minutes,
Processing 10 minutes, natural cooling completes aloe extraction process.Extracted using HTHP, heating rate is fast, high insulating effect, and
Soaking time is greatly shortened, while steam and consumption are reduced, there is energy-saving and emission-reduction, environmental protection, rapidly handled when special
The drug effect of traditional Chinese medicine extraction component can be kept not to be destroyed.
In above-mentioned technical proposal, in step (2), the broken wall treatment carries out broken wall treatment under 38000rpm rotating speed,
Time is 25 minutes；The ultrasonically treated power is 1000W, and frequency 80KHz, the time is 25 minutes；The hypergravity processing
Rotating speed be 25000rpm, the flow of concentrate is 80mL/min；The temperature of the freeze-drying is -80 DEG C, and pressure is 2Pa,
Evaporate liquid layer thickness 0.5mm.The Chinese medicine nano powder obtained using the method for freeze-drying has higher antioxidation and anti-
Bacterium activity, it is to avoid temperature is too high and cause drug activity to reduce problem in existing drying means.
In above-mentioned technical proposal, in step (1), ultrasonically treated power is 200W, frequency 30KHz；In step (3), surpass
The power of sonication is 500W, frequency 60KHz.
Present invention broken wall treatment first, followed by ultrasonically treated, then prepares the concentrate for limiting solid content, last profit
Handled with hypergravity, so as to prepare nanoscale traditional Chinese medicine powder, achieve unexpected technique effect.The particle diameter of above-mentioned traditional Chinese medicine powder is
90~120 nanometers, effect of hemostatic and antibacterial can be played with Chinese medical extract, hydroxyapatite, gelatin compatibility.
The invention also discloses a kind of hemostatic and antibacterial ointment note, including above-mentioned hemostatic and antibacterial ointment and mop；It is described to drag
Cloth includes lining cloth layer, lining bar layer, graphene fiber layer, ointment absorption stratum reticulare and the laminating layer being sequentially connected；The laminating layer
Some air-vents are evenly distributed with the thickness direction thereof, and each air-vent runs through the laminating layer；The lining cloth is provided with
Some air-vents；The hemostatic and antibacterial ointment is located on ointment absorption stratum reticulare.
In above-mentioned technical proposal, the graphene fiber layer includes both ends and pars intermedia, the graphene fiber layer
Pars intermedia is arranged in juxtaposition in strip；The lining bar layer is two lining bars, on the basis of the center line of lining cloth layer along its length, institute
Two lining bars are stated to set up separately in lining cloth layer center line both sides；The ointment adsorption net is viscose rayon/alginate fibre/bafta；Institute
The air permeability for stating ointment adsorption net is 160s/100mL；The lining bar is in the arc of crescent shape；The pass of the air-vent is in
Triangle.The invention also discloses a kind of preparation method of hemostatic and antibacterial medicine, by above-mentioned hemostatic and antibacterial ointment and phosphorus that pH is 8
Sour disodium hydrogen-sodium hydrate buffer solution is mixed according to 2: 1 mass ratio, ultrasonic disperse 2 hours；Then ointment quality 5% is added
Sodium alginate, then ultrasonic disperse 10 minutes obtains hemostatic and antibacterial medicine.
A small amount of calcium ion formation gel is run into by sodium alginate after the medicament contact surface of a wound disclosed by the invention, beneficial to by medicine
Thing is fixed on the surface of a wound without flowing into other normal structures, can obtain haemostatic effect well；The present invention uses viscose rayon/sea
Algae fiber/bafta plays absorption wound exudate, the protection surface of a wound, and Chinese medical extract can make dressing soft, with reference to traditional Chinese medicine powder, hydroxyl
Base apatite, sodium alginate have good inhibitory action to skin frequent infectious bacteria, mainly play bacteriostasis, and hemostasis is extracted
Liquid；Gelatin, sodium alginate, mulberry leaf powder, hydroxyapatite have bioactivity simultaneously, can prevent formation, the knot of fibrin element
The synthesis of histiocytic hyperplasia and collagen is formed, and with good biocompatibility, wound exudate can be absorbed, promotes wound
The characteristic such as mouth healing and skin regeneration；As antibacterial, hemostatic material, its security and antibacterial, haemostatic effect are more notable.
The effect of the present invention is as follows：
1. the present invention is due to being rationally provided with graphene fiber layer, some air-vents are offered on laminating layer, so as to
It is enough effectively to suppress because of ointment and contact human skin and exposed to the issuable bacterium of extraneous institute；Air permeability represents 100 millis
Rise the time that gas passes through, on the one hand the air permeability that the present invention limits ointment adsorption net is beneficial to ointment in loading effect thereon,
More importantly it is beneficial to during medical ointment plaster use, the exchange of gas molecule and hydrone, it is to avoid moisture, is that property of medicine performance is beaten
Lower basis.
2. being set in mop for the invention serves as a contrast bar, there is crucial work to the mechanical property for lifting mop by limiting
With, it is to avoid the contraction of mop, the also load beneficial to mop to medicine；Graphene fiber layer can be obtained by fiber impregnation graphene
Arrive, with physical sterilization deodorization, natural absorbing sweat taste removal, spontaneous heating, far infrared microcirculation effect, after being combined with ointment, can have
The allergy rate of effect reduction plaster, solves the auxiliary effect such as fuel factor that plaster needs.
3. the present invention uses microwave drying Chinese medicine, rather than conventional electrical heating, it is ensured that effective component of chinese medicine is not destroyed,
And microwave treatment is extracted to subsequent high temperature and is conducive to, it is easier to so that traditional Chinese medicine ingredients are rapidly separated out；Avoided by extracting respectively
The interaction of each composition when high temperature is extracted and cause drug effect lose or produce side effect, while using simultaneously extract hand
Section when high temperature is extracted in the toxic component of pseudo-ginseng/turmeric/aloe, the plaster toxicity obtained from is low, good effect.
4. in ointment disclosed by the invention, each traditional Chinese medicine ingredients compatibility rationally, especially makes public for the first time traditional Chinese medicine powder and extraction
Thing is mixed, and the combination based on nanoscale traditional Chinese medicine powder and extract, and the advantage for playing respective Chinese medicine also solves what is each influenceed
Problem；Such as mulberry leaf powder can neutralize the hypotoxicity of frankincense powder, clinopodium polycephalum, the cooperation of garden burnet can improve oxidation resistance and
Subside a swelling effect, the fruit of medicinal cornel can then neutralize pseudo-ginseng, Sophora alopecuroide it is cold, the capsule of weeping forsythia and polygala compatibility can slow down pain, and combine aloe
Can promotion organization recovery；In a word, ointment of the invention has good efficacy to external broken wound.
5. the traditional Chinese medicine powder of mixing at low temperature and extract solution of the invention, it is to avoid reaction from each other, also keep away
The loss of drug effect is exempted from, the ointment of preparation is maintained at low temperature, taken out when in use, with reference to the work of through hole, graphene and body temperature
With can cause the quick backheat of ointment and play a role.
It is not traditional raising with reference to ultrasonically treated 6. the present invention can refine Chinese medicine using broken wall treatment from cell level
Dispersiveness, but further broken particles, improve the crushing effect of broken wall treatment, so as to improve removal of impurity and improve powder
Broken treatment effect.
7. the present invention under hypergravity effect so that Chinese medicine nucleation, forms nanoscale product using high-gravity rotating bed,
Solve that prior art Chinese medicine particle is excessive, be unfavorable for the problems such as effect is played.At prior art has no hypergravity to polymer
The report of reason, and due to polymer nucleation process be not present reactivity, and polymer toughness itself, viscosity, into nuclearity all
It is more special, it is considered that to be not suitable for obtaining nanometer product using hypergravity method processing polymer.
Brief description of the drawings
Accompanying drawing 1 is the structural representation of the traditional Chinese medicinal ointment Tobe of the embodiment of the present invention one；
Accompanying drawing 2 is the structural representation of lining bar in the embodiment of the present invention one；
Accompanying drawing 3 is the structural representation of graphene fiber layer in the embodiment of the present invention one；
Wherein, 1, lining cloth layer；2nd, two lining bars；3rd, graphene fiber layer；30th, both ends；31st, pars intermedia；4th, ointment is inhaled
Attached stratum reticulare；5th, laminating layer；6th, air-vent.
Embodiment
Embodiment one
A kind of preparation method of hemostatic and antibacterial ointment, comprises the following steps：
(1) it is 100: 78: 54: 19: 11: 16: 23 pseudo-ginseng, the fruit of medicinal cornel, polygala, the capsule of weeping forsythia, aloe, turmeric, hardship by mass ratio
Bean or pea are added in pure water after being respectively washed to be soaked 30 minutes, bath raio 1: 25；Then take out three cleaned by microwave drying
7th, the fruit of medicinal cornel, polygala, the capsule of weeping forsythia, aloe, turmeric, Sophora alopecuroide；Then using water as extract solution, respectively to pseudo-ginseng, the fruit of medicinal cornel, polygala, the capsule of weeping forsythia
Carry out water extraction process and obtain pseudo-ginseng aqueous extract, fruit of medicinal cornel aqueous extract, polygala aqueous extract, capsule of weeping forsythia aqueous extract；With ethanol
For extract solution, ethanol extraction process is carried out to turmeric, Sophora alopecuroide respectively and obtains turmeric ethanol extract, the extraction of Sophora alopecuroide ethanol
Liquid；Aloe extract with the mixed liquor of pseudo-ginseng aqueous extract and turmeric ethanol extract and obtains pseudo-ginseng/turmeric/aloe extraction
Liquid；Then by fruit of medicinal cornel aqueous extract, polygala aqueous extract, capsule of weeping forsythia aqueous extract, Sophora alopecuroide ethanol extract, pseudo-ginseng/turmeric/reed
Luxuriant growth extract solution is in mixing, ultrasonically treated 6 minutes under normal temperature；The Chinese medical extract that solid content is 60% is concentrated to give for the first time；On
The technique for stating water extraction process is, boiling water pan feeding, then in being handled under 0.3MPa pressure 10 minutes, then atmospheric pressure reflux processing 15
Minute, natural cooling completes water extraction process；The technique of the ethanol extraction process is that then normal temperature pan feeding is adjusted in 1 minute
Temperature is reflux temperature, is handled 20 minutes, and natural cooling completes ethanol extraction process；The technique extracted to aloe
For, normal temperature batch mixing, it is reflux temperature that temperature is then adjusted in 15 minutes, is handled 10 minutes, and natural cooling is completed at aloe extraction
Reason；Ultrasonically treated power is 200W, frequency 30KHz；
(2) mass ratio is respectively washed for 100: 78: 11: 24: 22 matrimony vine, mulberry leaf, clinopodium polycephalum, garden burnet, frankincense latter
Rise to add in pure water and soak 30 minutes, bath raio 1: 30；Then carry out broken wall treatment to handle with ultrasonically treated, press filtration, mixed
Solution；Concentrate after mixed solution concentration obtains traditional Chinese medicine powder by hypergravity processing, freeze-drying, irradiation sterilization；It is above-mentioned broken
Wall processing carries out broken wall treatment under 38000rpm rotating speed, and the time is 25 minutes；The ultrasonically treated power is 1000W,
Frequency 80KHz, the time is 25 minutes；The rotating speed of hypergravity processing is 25000rpm, and the flow of concentrate is 80mL/min；Freezing
Dry temperature is -80 DEG C, and pressure is 2Pa, evaporation liquid layer thickness 0.5mm；90~120 nanometers of particle diameter, mercury arsenic is not detected, a huge sum of money
Category is less than 2mg/Kg；
Under (3) 5 degree, traditional Chinese medicine powder, hydroxyapatite are added in Chinese medical extract, ultrasonic disperse 3 hours is added bright
Glue, concentrates by second, obtains hemostatic and antibacterial ointment；Traditional Chinese medicine powder, hydroxyapatite, gelatin, the mass ratio of Chinese medical extract
For 38: 6: 12: 100；Ultrasonically treated power is 500W, frequency 60KHz.
Embodiment two
A kind of hemostatic and antibacterial ointment note, includes the hemostatic and antibacterial ointment and mop of embodiment one；Referring to accompanying drawing 1-3, drag
Lining cloth layer 1, two lining bars 2, graphene fiber layer 3, the ointment that cloth includes being sequentially connected adsorb stratum reticulare 4 and laminating layer 5.It is described
The thickness of laminating layer is 0.3 micron, and some air-vents 6 are evenly distributed with the thickness direction thereof, and each air-vent 6 runs through institute
Laminating layer 5 is stated, so that ointment adsorbs stratum reticulare 4 and connected with the external world by some air-vents 6.Two described lining 2 water proofs of bar
Flat raft is listed between lining cloth layer 1 and graphene fiber layer 3, and the graphene fiber layer is obtained by fiber impregnation graphene, fixed
On the front of the lining bar 2, lining cloth layer 1 is fixed on the back side of lining bar 2, and the graphene fiber layer 3 includes both ends 30
With pars intermedia 31, the pars intermedia 31 of the graphene fiber layer 3 is in arranged in strips, and the two ends of pars intermedia 31 connect described respectively
The both ends 30 of black alkene fibrous layer 3.On the basis of lining cloth 1 center line along its length of layer, two described lining bars 2 set up separately
1 center line both sides of lining cloth layer.It is described to serve as a contrast the arc that bar 2 is in crescent shape, and two lining bar 2 pairings settings, constitute one not closed
Flabellum contour structure.The ointment absorption stratum reticulare 4 is arranged on the top of graphene fiber layer 3, and the laminating layer 5 is sticked in institute
State on ointment absorption stratum reticulare 4, ointment adsorption net is viscose rayon/alginate fibre/bafta, its air permeability is 160s/100mL,
The lining cloth 1 is provided with some air-vents 6；The pass of air-vent 6 is triangular in shape.Count and show that it is killed for 24 hours to Escherichia coli
Bacterium rate is 99.97%, is 99.97% to 24 hours sterilizing rates of staphylococcus aureus, to 24 hours sterilizing rates of Candida albicans
For 99.92%；It is 7% to L92924 hours kill rates；TAC 987U/g；For 1 centimetre of wound of people's forearm (aspiration
Person) bleeding stopping period be 20 to 30 seconds, 3 people.
Embodiment three
A kind of hemostatic and antibacterial medicine, is prepared by the following manner, by the phosphorus that the hemostatic and antibacterial ointment of embodiment one and pH are 8
Sour disodium hydrogen-sodium hydrate buffer solution is mixed according to 2: 1 mass ratio, ultrasonic disperse 2 hours；Then ointment quality 5% is added
Sodium alginate, then ultrasonic disperse 10 minutes obtains hemostatic and antibacterial medicine.
Count and show that it is 99.99% to 24 hours sterilizing rates of Escherichia coli, staphylococcus aureus is sterilized for 24 hours
Rate is 99.98%, is 99.98% to 24 hours sterilizing rates of Candida albicans；It is 7% to L92924 hours kill rates；Total antioxygen
Change ability 984U/g；Bleeding stopping period for 1 centimetre of wound (volunteer) of people's forearm is 20 to 30 seconds, 3 people.
New zealand rabbit, body weight 2.6kg or so, it is randomly divided into blank control group and treatment group, every group 2, amobarbital note
Auricular vein anesthesia is penetrated, belly sterilization, in making a stringer otch along ventrimeson under arcus costarum, in the exposure liver middle period, uses knife blade
Cut in the liver middle period, surface of a wound blood exosmoses rapidly, 0.20g haemostatic medicaments are sprayed into the surface of a wound immediately and start timing, sterile yarn is covered
Cloth, then observes surface of a wound bleeding every 5s, until stopped bleeding or bleeding are to remove gauze not bleeding more than 10min
Hemostasis.Zoopery treatment group bleeding stopping period is 40 seconds, 35 seconds, and control group bleeding stopping period was more than 600 seconds.
Comparative example one
A kind of hemostatic and antibacterial medicine, compared with embodiment two, ointment is free of hydroxyapatite, sodium alginate, as remaining.
Count and show that it is 99.79% to 24 hours sterilizing rates of Escherichia coli, be to 24 hours sterilizing rates of staphylococcus aureus
99.75%, it is 99.87% to 24 hours sterilizing rates of Candida albicans；It is 8% to L92924 hours kill rates；Total antioxidation energy
Power 871U/g；Zoopery treatment group bleeding stopping period is 360 seconds, 420 seconds.
Comparative example two
A kind of hemostatic and antibacterial ointment note, compared with embodiment two, when prepared by ointment, matrimony vine, mulberry leaf, clinopodium polycephalum, garden burnet, breast
Perfume is extracted with water respectively, prepares extract, the form of Nano Chinese medicine powder is not used, as remaining.Count and show it to large intestine bar
24 hours sterilizing rates of bacterium are 98.12%, are 97.12% to 24 hours sterilizing rates of staphylococcus aureus, to Candida albicans 24
Hour sterilizing rate is 98.14%；It is 28% to L92924 hours kill rates；TAC 851U/g；Due to there is low toxicity
Property, do not do and stop blooding.
Comparative example three
A kind of hemostatic and antibacterial ointment note, compared with embodiment two, boils extraction process, the time adds as 5 times using conventional, its
It is remaining the same.Count and show that it is 99.21% to 24 hours sterilizing rates of Escherichia coli, to 24 hours sterilizing rates of staphylococcus aureus
It is 99.18% to 24 hours sterilizing rates of Candida albicans for 99.17%；It is 14% to L92924 hours kill rates；Total antioxidation
Ability 849U/g；Bleeding stopping period for 1 centimetre of wound (volunteer) of people's forearm is 70 to 90 seconds, 3 people.
Claims (7)
1. a kind of preparation method of hemostatic and antibacterial ointment, it is characterised in that comprise the following steps：
(1) add in pure water and soak 30 minutes after being respectively washed pseudo-ginseng, the fruit of medicinal cornel, polygala, the capsule of weeping forsythia, aloe, turmeric, Sophora alopecuroide,
Bath raio 1: 25；Then take out the pseudo-ginseng cleaned by microwave drying, the fruit of medicinal cornel, polygala, the capsule of weeping forsythia, aloe, turmeric, Sophora alopecuroide；
Then using water as extract solution, water extraction process is carried out to pseudo-ginseng, the fruit of medicinal cornel, polygala, the capsule of weeping forsythia respectively and obtains pseudo-ginseng aqueous extract, the fruit of medicinal cornel
Aqueous extract, polygala aqueous extract, capsule of weeping forsythia aqueous extract；Using ethanol as extract solution, ethanol is carried out to turmeric, Sophora alopecuroide respectively and carried
Processing is taken to obtain turmeric ethanol extract, Sophora alopecuroide ethanol extract；With the mixed of pseudo-ginseng aqueous extract and turmeric ethanol extract
Liquid is closed aloe extract to obtain pseudo-ginseng/turmeric/extract solution from aloe；Then by fruit of medicinal cornel aqueous extract, polygala aqueous extract, company
Aqueous extract, Sophora alopecuroide ethanol extract, pseudo-ginseng/turmeric/extract solution from aloe are stuck up in mixing, ultrasonically treated 6 minutes under normal temperature；The
Once it is concentrated to give the Chinese medical extract that solid content is 60%；The pseudo-ginseng, the fruit of medicinal cornel, polygala, the capsule of weeping forsythia, aloe, turmeric, Sophora alopecuroide
Mass ratio be 100: 78: 54: 19: 11: 16: 23；
(2) add in pure water and soak 30 minutes together after being respectively washed matrimony vine, mulberry leaf, clinopodium polycephalum, garden burnet, frankincense, bath raio 1:
30；Then carry out broken wall treatment to handle with ultrasonically treated, press filtration, obtain mixed solution；Concentrate warp after mixed solution concentration
Cross hypergravity processing, freeze-drying, irradiation sterilization obtain traditional Chinese medicine powder；The matrimony vine, mulberry leaf, clinopodium polycephalum, garden burnet, the quality of frankincense
Than for 100: 78: 11: 24: 22；
Under (3) 5 degree, traditional Chinese medicine powder, hydroxyapatite are added in Chinese medical extract, ultrasonic disperse 3 hours adds gelatin；Through
Cross second to concentrate, obtain hemostatic and antibacterial ointment；The traditional Chinese medicine powder, hydroxyapatite, gelatin, the mass ratio of Chinese medical extract are
38∶6∶12∶100。
2. the preparation method of hemostatic and antibacterial ointment according to claim 1, it is characterised in that in step (1), the water is extracted
The technique of processing is, boiling water pan feeding, then in handling 10 minutes under 0.3MPa pressure, and then atmospheric pressure reflux is handled 15 minutes, from
So cooling completes water extraction process；The technique of the ethanol extraction process is, normal temperature pan feeding, and temperature is then adjusted in 1 minute is
Reflux temperature, is handled 20 minutes, and natural cooling completes ethanol extraction process；The technique extracted to aloe is, normal temperature
Batch mixing, it is reflux temperature that temperature is then adjusted in 15 minutes, is handled 10 minutes, and natural cooling completes aloe extraction process；Ultrasound
The power of processing is 200W, frequency 30KHz；In step (2), the broken wall treatment is carried out at broken wall under 38000rpm rotating speed
Reason, the time is 25 minutes；The ultrasonically treated power is 1000W, and frequency 80KHz, the time is 25 minutes；At the hypergravity
The rotating speed of reason is 25000rpm, and the flow of concentrate is 80mL/min；The temperature of the freeze-drying is -80 DEG C, and pressure is
2Pa, evaporation liquid layer thickness 0.5mm；In step (3), ultrasonically treated power is 500W, frequency 60KHz.
3. the hemostatic and antibacterial ointment that according to claim 1 prepared by the preparation method of hemostatic and antibacterial ointment.
4. a kind of hemostatic and antibacterial ointment note, it is characterised in that it is anti-that the hemostatic and antibacterial ointment note includes hemostasis described in claim 3
Bacterium ointment and mop；The mop includes lining cloth layer, lining bar layer, graphene fiber layer, the ointment absorption stratum reticulare being sequentially connected
And laminating layer；The laminating layer is evenly distributed with some air-vents in the thickness direction thereof, and each air-vent is through described
Laminating layer；The lining cloth is provided with some air-vents；The hemostatic and antibacterial ointment is located on ointment absorption stratum reticulare.
5. hemostatic and antibacterial ointment note according to claim 4, it is characterised in that the graphene fiber layer include both ends and
Pars intermedia, the pars intermedia of the graphene fiber layer is arranged in juxtaposition in strip；The lining bar layer is two lining bars, with lining cloth layer edge
On the basis of the center line of length direction, described two lining bars set up separately in lining cloth layer center line both sides；The ointment adsorption net is viscous
Glue fiber/alginate fibre/bafta；The air permeability of the ointment adsorption net is 160s/100mL；The lining bar is in crescent shape
Arc；The pass of the air-vent is triangular in shape.
6. a kind of preparation method of hemostatic and antibacterial medicine, it is characterised in that be with pH by hemostatic and antibacterial ointment described in claim 3
8 sodium hydrate buffer solution of disodium hydrogen phosphate one is mixed according to 2: 1 mass ratio, ultrasonic disperse 2 hours；Then ointment matter is added
The sodium alginate of amount 5%, then ultrasonic disperse 10 minutes, obtain hemostatic and antibacterial medicine.
7. a kind of hemostatic and antibacterial medicine, it is characterised in that the hemostatic and antibacterial medicine is prepared by the following manner, will by right
Ask hemostatic and antibacterial ointment described in 3 to be mixed with pH for 8 sodium hydrate buffer solution of disodium hydrogen phosphate one according to 2: 1 mass ratio, surpass
Sound is scattered 2 hours；Then the sodium alginate of ointment quality 5% is added, then ultrasonic disperse 10 minutes, obtain hemostatic and antibacterial medicine.
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