CN107174602A - A kind of antibacterial surface of a wound ointment and patch, antibacterial Wound dressing - Google Patents
A kind of antibacterial surface of a wound ointment and patch, antibacterial Wound dressing Download PDFInfo
- Publication number
- CN107174602A CN107174602A CN201710206703.3A CN201710206703A CN107174602A CN 107174602 A CN107174602 A CN 107174602A CN 201710206703 A CN201710206703 A CN 201710206703A CN 107174602 A CN107174602 A CN 107174602A
- Authority
- CN
- China
- Prior art keywords
- ointment
- minutes
- traditional chinese
- wound
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Abstract
The present invention relates to a kind of antibacterial surface of a wound ointment and patch, antibacterial Wound dressing, antibacterial surface of a wound ointment includes traditional Chinese medicinal ointment, traditional Chinese medicine powder, sea-mussel mucin；Antibacterial surface of a wound patch includes mop, ointment, diaphragm；Diaphragm wraps up mop；Mop includes the lining cloth layer, graphene fiber layer, ointment absorption stratum reticulare being sequentially connected；Ointment is located on ointment absorption stratum reticulare；Antibacterial Wound dressing includes antibacterial surface of a wound ointment and buffer solution.The product bacteriostasis rate of the present invention is high, wound repair effect is good.
Description
Technical field
The present invention relates to drug material, and in particular to a kind of antibacterial surface of a wound ointment and patch, antibacterial Wound dressing.
Background technology
Medical dressing major function is covering, protection damaged skin, while providing contributes to the environment of wound healing, is tackled
Human body is non-stimulated, will not cause poisoning, lesion etc..Traditional ointment patch generally includes ointment and Tobe, and user is using
During, if poor air permeability, Bacteria suppression ability, it will bring secondary injury to user.In order to increase ointment patch
The medicinal ability such as Bacteria suppression, ointment composition is crucial, simultaneously because ointment can be absorbed by user, composition can influence ointment
The property of medicine, and mop can offset the property of medicine of ointment.Current drug dressing species is various, but there is no a kind of dressing while having concurrently anti-
Bacterium, wound healing promoting, the function that trace element and nutrition are provided.
The content of the invention
In view of the above-mentioned problems, it is an object of the invention to provide a kind of antibacterial surface of a wound ointment and patch, it is intended to solve existing
The ointment biocidal property of technology is poor, so that the problems such as influenceing or even offset ointment drug effect, disclosed ointment composition has good
The effect of antibacterial wound repairing.
To achieve these goals, the present invention uses following technical scheme：A kind of antibacterial surface of a wound ointment, including traditional Chinese medicinal ointment,
Traditional Chinese medicine powder, sea-mussel mucin；Being prepared as the traditional Chinese medicinal ointment, caulis lonicerae, rhodiola root, polygala, Radix Angelicae Sinensis, the fleece-flower root are respectively washed
Add in pure water and soak 30 minutes afterwards, bath raio 1: 15；Then take out the caulis lonicerae cleaned by microwave drying, rhodiola root,
Polygala, Radix Angelicae Sinensis, the fleece-flower root；Then using water as extract solution, extraction process is carried out to caulis lonicerae, Radix Angelicae Sinensis respectively and obtains caulis lonicerae water extraction
Take liquid, Radix Angelicae Sinensis aqueous extract；Using ethanol as extract solution, extraction process is carried out to rhodiola root, polygala respectively and obtains rhodiola root ethanol
Extract solution, polygala ethanol extract；The fleece-flower root is carried with the mixed liquor of caulis lonicerae aqueous extract and polygala ethanol extract
Obtain caulis lonicerae/polygala/multiflorum extracting solution；Then by Radix Angelicae Sinensis aqueous extract, rhodiola root ethanol extract, caulis lonicerae/remote
Will/multiflorum extracting solution under normal temperature in mixing, ultrasonically treated 3~5 minutes, then detains pot stewing 2 minutes；Then it is concentrated to give for the first time
Traditional Chinese medicinal ointment concentrate；Being prepared as the traditional Chinese medicine powder, is added pure together after acorus graminens soland, mulberry leaf, cassia twig, stone-like omphalia are respectively washed
Soaked 30 minutes in water, bath raio 1: 50；Then carry out broken wall treatment to handle with ultrasonically treated, press filtration, obtain mixed solution；Mixing
Handle, be freeze-dried by hypergravity after solution concentration, irradiation sterilization obtains traditional Chinese medicine powder；Under the conditions of ice-water bath, by traditional Chinese medicine powder, make a gift of
The shellfish mucoprotein aqueous solution is added in traditional Chinese medicinal ointment concentrate, ultrasonic disperse 3 hours, is concentrated by second, is obtained antibacterial surface of a wound medicine
Cream.
The invention also discloses a kind of preparation method of antibacterial surface of a wound ointment, comprise the following steps, by caulis lonicerae, red scape
My god, polygala, Radix Angelicae Sinensis, the fleece-flower root be respectively washed after add pure water in soak 30 minutes, bath raio 1: 15；Then take out dry by microwave
The dry caulis lonicerae cleaned, rhodiola root, polygala, Radix Angelicae Sinensis, the fleece-flower root；Then using water as extract solution, respectively to caulis lonicerae, Radix Angelicae Sinensis
Carry out extraction process and obtain caulis lonicerae aqueous extract, Radix Angelicae Sinensis aqueous extract；Using ethanol as extract solution, respectively to rhodiola root, polygala
Carry out extraction process and obtain rhodiola root ethanol extract, polygala ethanol extract；Carried with caulis lonicerae aqueous extract with polygala ethanol
The mixed liquor of liquid is taken to the fleece-flower root extract obtaining caulis lonicerae/polygala/multiflorum extracting solution；Then by Radix Angelicae Sinensis aqueous extract,
Rhodiola root ethanol extract, caulis lonicerae/polygala/multiflorum extracting solution under normal temperature mix, ultrasonically treated 5 minutes, then detain pot boil in a covered pot over a slow fire
Forging 2 minutes；Then traditional Chinese medicinal ointment concentrate is concentrated to give for the first time；The traditional Chinese medicine powder is prepared as, by acorus graminens soland, mulberry leaf, osmanthus
Branch, stone-like omphalia are added in pure water together after being respectively washed to be soaked 30 minutes, bath raio 1: 50；Then carry out at broken wall treatment and ultrasound
Reason, press filtration processing, obtain mixed solution；Handle, be freeze-dried by hypergravity after mixed solution concentration, during irradiation sterilization obtains
Medicinal powder；Under the conditions of ice-water bath, traditional Chinese medicine powder, the sea-mussel mucin aqueous solution are added in traditional Chinese medicinal ointment concentrate, ultrasonic disperse 3 hours,
Concentrated by second, obtain antibacterial surface of a wound ointment.
The invention also discloses a kind of antibacterial surface of a wound patch, including mop, ointment, diaphragm；The diaphragm parcel is dragged
Cloth；The mop includes the lining cloth layer, graphene fiber layer, ointment absorption stratum reticulare being sequentially connected；The ointment is inhaled positioned at ointment
On attached stratum reticulare；The ointment adsorption net is bafta, silk fabrics, staple fabric, polycarbonate fabric or polyester fiber
Fabric；The air permeability of the ointment adsorption net is 200s/100mL；The ointment is above-mentioned antibacterial surface of a wound ointment.
The invention also discloses a kind of antibacterial Wound dressing, it is characterised in that：The antibacterial Wound dressing includes above-mentioned suppression
Bacterium surface of a wound ointment and buffer solution；The mass ratio of the antibacterial surface of a wound ointment and buffer solution is 1: 0.2；The buffer solution is phosphoric acid
Salt buffer.
The invention also discloses a kind of preparation method of antibacterial Wound dressing, comprise the following steps, by caulis lonicerae, red scape
My god, polygala, Radix Angelicae Sinensis, the fleece-flower root be respectively washed after add pure water in soak 30 minutes, bath raio 1: 15；Then take out dry by microwave
The dry caulis lonicerae cleaned, rhodiola root, polygala, Radix Angelicae Sinensis, the fleece-flower root；Then using water as extract solution, respectively to caulis lonicerae, Radix Angelicae Sinensis
Carry out extraction process and obtain caulis lonicerae aqueous extract, Radix Angelicae Sinensis aqueous extract；Using ethanol as extract solution, respectively to rhodiola root, polygala
Carry out extraction process and obtain rhodiola root ethanol extract, polygala ethanol extract；Carried with caulis lonicerae aqueous extract with polygala ethanol
The mixed liquor of liquid is taken to the fleece-flower root extract obtaining caulis lonicerae/polygala/multiflorum extracting solution；Then by Radix Angelicae Sinensis aqueous extract,
Rhodiola root ethanol extract, caulis lonicerae/polygala/multiflorum extracting solution under normal temperature in mixing, ultrasonically treated 5 minutes, then detains pot stewing 2
Minute；Then traditional Chinese medicinal ointment concentrate is concentrated to give for the first time；The traditional Chinese medicine powder is prepared as, by acorus graminens soland, mulberry leaf, cassia twig,
Stone-like omphalia is added in pure water together after being respectively washed to be soaked 30 minutes, bath raio 1: 50；Then broken wall treatment and ultrasonically treated, pressure are carried out
Filter is handled, and obtains mixed solution；Handle, be freeze-dried by hypergravity after mixed solution concentration, irradiation sterilization obtains traditional Chinese medicine powder；
Under the conditions of ice-water bath, traditional Chinese medicine powder, the sea-mussel mucin aqueous solution are added in traditional Chinese medicinal ointment concentrate, ultrasonic disperse 3 hours, by the
Secondary concentration, obtains antibacterial surface of a wound ointment；Antibacterial surface of a wound ointment is mixed with phosphate buffer, antibacterial Wound dressing is obtained.
In the present invention, the technique of the water extraction process is, boiling water pan feeding, then in handling 30 points under 0.2MPa pressure
Clock, then atmospheric pressure reflux processing 40 minutes, natural cooling completes water extraction process；The technique of the ethanol extraction process is, often
Warm pan feeding, it is reflux temperature that temperature is then adjusted in 10 minutes, is handled 5 minutes, and natural cooling completes ethanol extraction process；It is described
The technique extracted to the fleece-flower root is that then normal temperature batch mixing adjusts temperature for reflux temperature, handle 10 minutes in 5 minutes, from
So cooling completes fleece-flower root extraction process；The ultrasonically treated power is 200W, frequency 30KHz；The broken wall treatment be
Broken wall treatment is carried out under 45000rpm rotating speed, the time is 6~7 minutes；The ultrasonically treated power is 1000W, frequency
80KHz, the time is 35~36 minutes；The rotating speed of the hypergravity processing is 28000rpm, and the flow of concentrate is 120mL/
min；The temperature of freeze-drying is -80 DEG C, and pressure is 5Pa, evaporation liquid layer thickness 0.5mm；The power of ultrasonic disperse is 800W, frequency
Rate 40KHz.
In the present invention, the caulis lonicerae, rhodiola root, polygala, Radix Angelicae Sinensis, the mass ratio of the fleece-flower root are 28: 19: 11: 87: 100；
Acorus graminens soland, mulberry leaf, cassia twig, the mass ratio of stone-like omphalia are 5: 100: 47: 7；The solid content of the traditional Chinese medicinal ointment concentrate be 55~
58%；The traditional Chinese medicine powder, the sea-mussel mucin aqueous solution, the mass ratio of traditional Chinese medicinal ointment concentrate are 26: 18: 100；The mussel glues egg
The mass concentration of white water solution is 18%.
The invention also discloses application of the above-mentioned antibacterial surface of a wound ointment in antimicrobial form wound repair medicine is prepared.
Air permeability represents the time that 100 milliliters of gases pass through, and the air permeability that the present invention limits ointment adsorption net is on the one hand sharp
In ointment in loading effect thereon, more importantly it is beneficial to during medical ointment plaster use, the friendship of gas molecule and hydrone
Change, be that property of medicine performance lays the first stone.The particle diameter of traditional Chinese medicine powder prepared by the present invention is 88~96 nanometers, first broken wall treatment, then
Using ultrasonically treated, the concentrate for limiting solid content is then prepared, is finally handled using hypergravity, so as to prepare nanoscale Chinese medicine
Powder, achieves unexpected technique effect.
The effect of the present invention is as follows：
1. antibacterial surface of a wound patch disclosed by the invention, including graphene fiber layer, can be molten by conventional fibre impregnated graphite alkene
Liquid is thermally treated resulting in again；Due to being rationally provided with graphene fiber layer, with physical sterilization deodorization, natural absorbing sweat taste removal, spontaneous
Heat, the effect of far infrared microcirculation, after being combined with ointment, can effectively reduce the allergy rate of plaster, solve the thermal effect that plaster needs
Auxiliary effect should be waited；So as to effectively suppress with contact human skin and issuable thin exposed to extraneous institute because of ointment
Bacterium.
2. the invention adds sea-mussel mucin in ointment, on the one hand with good biocompatibility,
During use, sea-mussel mucin can absorb moisture so that traditional Chinese medicine ingredients play drug effect；In addition, sea-mussel mucin is in cream
Medicine can pin moisture in preserving, and both avoid Chinese medicine damp failure, can play effect at once when in use again, accelerate slight illness and go
Remove；3rd is, with good cementability, beneficial to the mixing of other compositions, and together with important, to play bacteriostasis.
3. in ointment disclosed by the invention, each traditional Chinese medicine ingredients compatibility rationally, especially makes public for the first time traditional Chinese medicine powder and extraction
Thing is mixed, and the combination based on nanoscale traditional Chinese medicine powder and extract, and the advantage for playing respective Chinese medicine also solves what is each influenceed
Problem；Such as mulberry leaf powder can neutralize the hypotoxicity of stone-like omphalia powder, and the cooperation of caulis lonicerae/polygala/fleece-flower root can improve the surface of a wound and repair
Multiple effect, acorus graminens soland can slow down pain with cassia twig compatibility, and rhodiola root, mulberry leaf can increase cell proliferation ability at the surface of a wound,
Accelerate to recover；In a word, ointment of the invention has good efficacy to external bruise.
4. in the preparation of ointment disclosed by the invention, the present invention uses microwave drying Chinese medicine, rather than conventional electrical heating, can
Ensure that effective component of chinese medicine is not destroyed, and microwave treatment is extracted to subsequent high temperature and is conducive to, it is easier to so that traditional Chinese medicine ingredients
Rapidly separate out；By extract respectively avoid the interaction of each composition when high temperature is extracted and cause drug effect lose or produce it is secondary
Effect, while recycling the stewing forging of button pot, the plaster toxicity obtained from is low, good effect.
5. the traditional Chinese medicine powder of mixing at low temperature of the invention, the sea-mussel mucin aqueous solution add traditional Chinese medicinal ointment concentrate,
Reaction from each other is avoided, the loss of drug effect is it also avoid, the ointment of preparation is maintained at low temperature, and close by diaphragm
Envelope, takes out, with reference to the effect of sea-mussel mucin and body temperature, can cause the quick backheat of ointment and play a role when in use.
It is not traditional raising with reference to ultrasonically treated 6. the present invention can refine Chinese medicine using broken wall treatment from cell level
Dispersiveness, but further broken particles, improve the crushing effect of broken wall treatment, so as to improve removal of impurity and improve powder
Broken treatment effect；The present invention under hypergravity effect so that Chinese medicine nucleation, forms nanoscale product using high-gravity rotating bed,
Solve that prior art Chinese medicine particle is excessive, be unfavorable for the problems such as effect is played.At prior art has no hypergravity to polymer
The report of reason, and due to polymer nucleation process be not present reactivity, and polymer toughness itself, viscosity, into nuclearity all
It is more special, it is considered that to be not suitable for obtaining nanometer product using hypergravity method processing polymer.
Embodiment
Embodiment one
A kind of preparation method of antibacterial surface of a wound ointment, comprises the following steps：By caulis lonicerae, rhodiola root, polygala, Radix Angelicae Sinensis, what
The tuber of multiflower knotweed is added in pure water after being respectively washed to be soaked 30 minutes, bath raio 1: 15；Then take out by bearing that microwave drying is cleaned
Winter rattan, rhodiola root, polygala, Radix Angelicae Sinensis, the fleece-flower root；Then using water as extract solution, extraction process is carried out to caulis lonicerae, Radix Angelicae Sinensis respectively and obtained
To caulis lonicerae aqueous extract, Radix Angelicae Sinensis aqueous extract；Using ethanol as extract solution, extraction process is carried out to rhodiola root, polygala respectively and obtained
To rhodiola root ethanol extract, polygala ethanol extract；With caulis lonicerae aqueous extract and the mixed liquor pair of polygala ethanol extract
The fleece-flower root extract obtaining caulis lonicerae/polygala/multiflorum extracting solution；Then Radix Angelicae Sinensis aqueous extract, rhodiola root ethanol are extracted
Liquid, caulis lonicerae/polygala/multiflorum extracting solution under normal temperature in mixing, ultrasonically treated 5 minutes, then detains the stewing forging of pot 2 minutes；Then
Once it is concentrated to give traditional Chinese medicinal ointment concentrate；Being prepared as the traditional Chinese medicine powder, acorus graminens soland, mulberry leaf, cassia twig, stone-like omphalia are respectively washed
Add in pure water and soak 30 minutes together afterwards, bath raio 1: 50；Then carry out broken wall treatment to handle with ultrasonically treated, press filtration, obtain
Mixed solution；Handle, be freeze-dried by hypergravity after mixed solution concentration, irradiation sterilization obtains traditional Chinese medicine powder；Ice-water bath condition
Under, traditional Chinese medicine powder, the sea-mussel mucin aqueous solution are added in traditional Chinese medicinal ointment concentrate, ultrasonic disperse 3 hours is concentrated by second,
Obtain antibacterial surface of a wound ointment.
Above-mentioned caulis lonicerae, rhodiola root, polygala, Radix Angelicae Sinensis, the mass ratio of the fleece-flower root are 28: 19: 11: 87: 100；Acorus graminens soland,
Mulberry leaf, cassia twig, the mass ratio of stone-like omphalia are 5: 100: 47: 7；The traditional Chinese medicine powder, the sea-mussel mucin aqueous solution, traditional Chinese medicinal ointment concentrate
Mass ratio is 26: 18: 100；The mass concentration of the sea-mussel mucin aqueous solution is 18%.
Above-mentioned first time is concentrated to give the traditional Chinese medicinal ointment concentrate that solid content is 55%, in mixing beneficial to the scattered of each composition
Uniformly, so that when concentrating for second, Nano Chinese medicine powder is not in the defects such as local cluster, and the performance for plaster curative effect is provided
Good basis；Using microwave drying Chinese medicine, rather than conventional electrical heating, it is ensured that effective component of chinese medicine is not destroyed, Er Qiewei
Ripple processing is extracted to subsequent high temperature to be conducive to, it is easier to so that traditional Chinese medicine ingredients are rapidly separated out；The technique of the water extraction process is,
Boiling water pan feeding, then in processing 30 minutes under 0.2MPa pressure, then atmospheric pressure reflux is handled 40 minutes, and natural cooling completes water extraction
Take processing；The technique of the ethanol extraction process is that then normal temperature pan feeding adjusts temperature for reflux temperature, processing 5 in 10 minutes
Minute, natural cooling completes ethanol extraction process；The technique extracted to the fleece-flower root is, normal temperature batch mixing, then 5 minutes
Interior regulation temperature is reflux temperature, is handled 10 minutes, natural cooling completes fleece-flower root extraction process；The ultrasonically treated power
For 200W, frequency 30KHz；The broken wall treatment is carries out broken wall treatment under 45000rpm rotating speed, and the time is 7 minutes；Institute
Ultrasonically treated power is stated for 1000W, frequency 80KHz, the time is 36 minutes；The rotating speed of hypergravity processing is
28000rpm, the flow of concentrate is 120mL/min；The temperature of freeze-drying is -80 DEG C, and pressure is 5Pa, evaporates liquid layer thickness
0.5mm.Extracted using HTHP, heating rate is fast, high insulating effect, and greatly shortens soaking time, at the same steam and
Consumption is reduced, and has the advantages that energy-saving and emission-reduction, environmental protection, rapidly handled when special can keep the drug effect of traditional Chinese medicine extraction component not by
Destruction；95 nanometers of traditional Chinese medicine powder particle diameter, mercury arsenic is not detected, and heavy metal is less than 2mg/Kg；The power of ultrasonic disperse is 500W, frequency
60KHz。
Embodiment two
A kind of preparation method of antibacterial surface of a wound ointment, compared with embodiment one, it is 58% that solid content is concentrated to give for the first time
Traditional Chinese medicinal ointment concentrate；Broken wall treatment, the time is 6 minutes；Sonication treatment time is 35 minutes；As remaining, antibacterial wound is obtained
Face ointment.
Embodiment three
A kind of antibacterial surface of a wound patch, including mop, the ointment of embodiment one, diaphragm；The diaphragm wraps up mop；Institute
State lining cloth layer, graphene fiber layer, ointment absorption stratum reticulare that mop includes being sequentially connected；The ointment is located at ointment and adsorbs stratum reticulare
On；The ointment adsorption net is the bafta that air permeability is 200s/100mL.Count and show that it is sterilized for 24 hours to Escherichia coli
Rate is 99.95%, is 99.97% to 24 hours sterilizing rates of staphylococcus aureus, is to 24 hours sterilizing rates of Candida albicans
99.98%；It is 4% to L92924 hours kill rates；TAC 978U/g；Slightly scratch for people's forearm (volunteer,
1.8-2 centimetres, slightly bleeding) paste twice, fully recover within 12 hours every time, 3 people experiment.
Example IV
A kind of antibacterial Wound dressing, by antibacterial surface of a wound ointment and the phosphate buffer in mass ratio 1: 0.2 of embodiment two
Mixing.
Count and show that it is 99.99% to 24 hours sterilizing rates of Escherichia coli, staphylococcus aureus is sterilized for 24 hours
Rate is 99.94%, is 99.95% to 24 hours sterilizing rates of Candida albicans；It is 6% to L92924 hours kill rates；Total antioxygen
Change ability 997U/g；(volunteer, 2-2.4 centimetres, slightly bleeding), sprayed coating, 8 hours every time, three times are slightly scratched for people's forearm
Fully recover, 3 people experiment.
Comparative example one
A kind of ointment note, compared with embodiment three, ointment is free of sea-mussel mucin, and mop needs tack coat, as remaining.
Count and show that it is 88.81% to 24 hours sterilizing rates of Escherichia coli, be to 24 hours sterilizing rates of staphylococcus aureus
88.71%, it is 89.61% to 24 hours sterilizing rates of Candida albicans；It is 8% to L92924 hours kill rates；Total antioxidation energy
Power 768U/g；(volunteer, 1.8-2 centimetres, slightly bleeding) patch is slightly scratched for people's forearm five times, is fully recovered within 12 hours every time, 3
People tests, and pastes three times and does not fully recover.
Comparative example two
A kind of Wound dressing, compared with example IV, when prepared by ointment, the form of Nano Chinese medicine powder is not used, and is used
Water extracting mode, as remaining.Count and show that it is 95.21% to 24 hours sterilizing rates of Escherichia coli, to Staphylococcus aureus
24 hours sterilizing rates of bacterium are 96.01%, are 93.02% to 24 hours sterilizing rates of Candida albicans；To L92924 hours kill rates
For 29%；TAC 899U/g；Due to there is hypotoxicity, human experimentation is not done.
Claims (10)
1. a kind of antibacterial surface of a wound ointment, it is characterised in that：The antibacterial surface of a wound ointment includes traditional Chinese medicinal ointment, traditional Chinese medicine powder, mussel and glues egg
In vain；Being prepared as the traditional Chinese medicinal ointment, adds in pure water after caulis lonicerae, rhodiola root, polygala, Radix Angelicae Sinensis, the fleece-flower root are respectively washed and soaks
Bubble 30 minutes, bath raio 1: 15；Then take out the caulis lonicerae cleaned by microwave drying, rhodiola root, polygala, Radix Angelicae Sinensis, He Shou
Crow；Then using water as extract solution, extraction process is carried out to caulis lonicerae, Radix Angelicae Sinensis respectively and obtains caulis lonicerae aqueous extract, Radix Angelicae Sinensis water extraction
Take liquid；Using ethanol as extract solution, extraction process is carried out to rhodiola root, polygala respectively and obtains rhodiola root ethanol extract, polygala second
Alcohol extract；The fleece-flower root extract with the mixed liquor of caulis lonicerae aqueous extract and polygala ethanol extract obtain caulis lonicerae/
Polygala/multiflorum extracting solution；Then Radix Angelicae Sinensis aqueous extract, rhodiola root ethanol extract, caulis lonicerae/polygala/fleece-flower root are extracted
Liquid under normal temperature in mixing, ultrasonically treated 5 minutes, then detains the stewing forging of pot 2 minutes；Then traditional Chinese medicinal ointment concentrate is concentrated to give for the first time；
Being prepared as the traditional Chinese medicine powder, adds and 30 points is soaked in pure water together after acorus graminens soland, mulberry leaf, cassia twig, stone-like omphalia are respectively washed
Clock, bath raio 1: 50；Then carry out broken wall treatment to handle with ultrasonically treated, press filtration, obtain mixed solution；Passed through after mixed solution concentration
Cross hypergravity processing, freeze-drying, irradiation sterilization obtain traditional Chinese medicine powder；It is under the conditions of ice-water bath, traditional Chinese medicine powder, sea-mussel mucin is water-soluble
Liquid is added in traditional Chinese medicinal ointment concentrate, ultrasonic disperse 3 hours, is concentrated by second, is obtained antibacterial surface of a wound ointment.
2. antibacterial surface of a wound ointment according to claim 1, it is characterised in that：The technique of the water extraction process is that boiling water enters
Material, then in processing 30 minutes under 0.2MPa pressure, then atmospheric pressure reflux is handled 40 minutes, and natural cooling is completed at water extraction
Reason；The technique of the ethanol extraction process is that then normal temperature pan feeding adjusts temperature for reflux temperature, handle 5 points in 10 minutes
Clock, natural cooling completes ethanol extraction process；The technique extracted to the fleece-flower root is, normal temperature batch mixing, then in 5 minutes
Regulation temperature is reflux temperature, is handled 10 minutes, and natural cooling completes fleece-flower root extraction process；The ultrasonically treated power is
200W, frequency 30KHz；The broken wall treatment is carries out broken wall treatment under 45000rpm rotating speed, and the time is 6~7 minutes；Institute
Ultrasonically treated power is stated for 1000W, frequency 80KHz, the time is 35~36 minutes；The rotating speed of hypergravity processing is
28000rpm, the flow of concentrate is 120mL/min；The temperature of freeze-drying is -80 DEG C, and pressure is 5Pa, evaporates liquid layer thickness
0.5mm；The power of ultrasonic disperse is 800W, frequency 40KHz.
3. antibacterial surface of a wound ointment according to claim 1, it is characterised in that：The caulis lonicerae, rhodiola root, polygala, Radix Angelicae Sinensis, what
The mass ratio of the tuber of multiflower knotweed is 28: 19: 11: 87: 100；Acorus graminens soland, mulberry leaf, cassia twig, the mass ratio of stone-like omphalia are 5: 100: 47: 7；Institute
The solid content for stating traditional Chinese medicinal ointment concentrate is 55~58%；The traditional Chinese medicine powder, the sea-mussel mucin aqueous solution, the matter of traditional Chinese medicinal ointment concentrate
Amount is than being 26: 18: 100；The mass concentration of the sea-mussel mucin aqueous solution is 18%.
4. application of the antibacterial surface of a wound ointment in antimicrobial form wound repair medicine is prepared described in claim 1.
5. a kind of preparation method of antibacterial surface of a wound ointment, it is characterised in that comprise the following steps, by caulis lonicerae, rhodiola root, remote
Will, Radix Angelicae Sinensis, the fleece-flower root are added in pure water after being respectively washed to be soaked 30 minutes, bath raio 1: 15；Then take out and obtained by microwave drying
To the caulis lonicerae of cleaning, rhodiola root, polygala, Radix Angelicae Sinensis, the fleece-flower root；Then using water as extract solution, caulis lonicerae, Radix Angelicae Sinensis are carried out respectively
Extraction process obtains caulis lonicerae aqueous extract, Radix Angelicae Sinensis aqueous extract；Using ethanol as extract solution, rhodiola root, polygala are carried out respectively
Extraction process obtains rhodiola root ethanol extract, polygala ethanol extract；With caulis lonicerae aqueous extract and polygala ethanol extract
Mixed liquor the fleece-flower root is carried out to extract and obtain caulis lonicerae/polygala/multiflorum extracting solution；Then by Radix Angelicae Sinensis aqueous extract, red scape
Its ethanol extract, caulis lonicerae/polygala/multiflorum extracting solution under normal temperature in mixing, ultrasonically treated 5 minutes, then detains stewing 2 points of the forging of pot
Clock；Then traditional Chinese medicinal ointment concentrate is concentrated to give for the first time；The traditional Chinese medicine powder is prepared as, by acorus graminens soland, mulberry leaf, cassia twig, thunder
Ball is added in pure water together after being respectively washed to be soaked 30 minutes, bath raio 1: 50；Then broken wall treatment and ultrasonically treated, press filtration are carried out
Processing, obtains mixed solution；Handle, be freeze-dried by hypergravity after mixed solution concentration, irradiation sterilization obtains traditional Chinese medicine powder；Ice
Under water bath condition, traditional Chinese medicine powder, the sea-mussel mucin aqueous solution are added in traditional Chinese medicinal ointment concentrate, ultrasonic disperse 3 hours, by second
Secondary concentration, obtains antibacterial surface of a wound ointment.
6. the preparation method of antibacterial surface of a wound ointment according to claim 5, it is characterised in that：The technique of the water extraction process
For, boiling water pan feeding, then in processing 30 minutes under 0.2MPa pressure, then atmospheric pressure reflux is handled 40 minutes, and natural cooling is completed
Water extraction process；The technique of the ethanol extraction process is that then normal temperature pan feeding adjusts temperature for reflux temperature in 10 minutes,
Processing 5 minutes, natural cooling completes ethanol extraction process；The technique extracted to the fleece-flower root is, normal temperature batch mixing, then
It is reflux temperature that temperature is adjusted in 5 minutes, is handled 10 minutes, and natural cooling completes fleece-flower root extraction process；It is described ultrasonically treated
Power be 200W, frequency 30KHz；The broken wall treatment to carry out broken wall treatment under 45000rpm rotating speed, the time is 6~
7 minutes；The ultrasonically treated power is 1000W, and frequency 80KHz, the time is 35~36 minutes；Turn of the hypergravity processing
Speed is 28000rpm, and the flow of concentrate is 120mL/min；The temperature of freeze-drying is -80 DEG C, and pressure is 5Pa, evaporates liquid layer
Thickness 0.5mm；The power of ultrasonic disperse is 800W, frequency 40KHz.
7. the preparation method of antibacterial surface of a wound ointment according to claim 5, it is characterised in that：It is the caulis lonicerae, rhodiola root, remote
Will, Radix Angelicae Sinensis, the mass ratio of the fleece-flower root are 28: 19: 11: 87: 100；Acorus graminens soland, mulberry leaf, cassia twig, the mass ratio of stone-like omphalia are 5:
100∶47∶7；The solid content of the traditional Chinese medicinal ointment concentrate is 55~58%；The traditional Chinese medicine powder, the sea-mussel mucin aqueous solution, Chinese medicine
The mass ratio of cream concentrate is 26: 18: 100；The mass concentration of the sea-mussel mucin aqueous solution is 18%.
8. a kind of antibacterial surface of a wound patch, it is characterised in that：The antibacterial surface of a wound patch includes mop, ointment, diaphragm；It is described to protect
Cuticula wraps up mop；The mop includes the lining cloth layer, graphene fiber layer, ointment absorption stratum reticulare being sequentially connected；The ointment
On ointment absorption stratum reticulare；The ointment adsorption net be bafta, silk fabrics, staple fabric, polycarbonate fabric or
Person's dacron fabric；The air permeability of the ointment adsorption net is 200s/100mL；The ointment is antibacterial described in claim 1
Surface of a wound ointment.
9. a kind of antibacterial Wound dressing, it is characterised in that：The antibacterial Wound dressing includes antibacterial surface of a wound medicine described in claim 1
Cream and buffer solution；The mass ratio of the antibacterial surface of a wound ointment and buffer solution is 1: 0.2；The buffer solution is phosphate-buffered
Liquid.
10. a kind of preparation method of antibacterial Wound dressing, it is characterised in that comprise the following steps, by caulis lonicerae, rhodiola root, remote
Will, Radix Angelicae Sinensis, the fleece-flower root are added in pure water after being respectively washed to be soaked 30 minutes, bath raio 1: 15；Then take out and obtained by microwave drying
To the caulis lonicerae of cleaning, rhodiola root, polygala, Radix Angelicae Sinensis, the fleece-flower root；Then using water as extract solution, caulis lonicerae, Radix Angelicae Sinensis are carried out respectively
Extraction process obtains caulis lonicerae aqueous extract, Radix Angelicae Sinensis aqueous extract；Using ethanol as extract solution, rhodiola root, polygala are carried out respectively
Extraction process obtains rhodiola root ethanol extract, polygala ethanol extract；With caulis lonicerae aqueous extract and polygala ethanol extract
Mixed liquor the fleece-flower root is carried out to extract and obtain caulis lonicerae/polygala/multiflorum extracting solution；Then by Radix Angelicae Sinensis aqueous extract, red scape
Its ethanol extract, caulis lonicerae/polygala/multiflorum extracting solution under normal temperature in mixing, ultrasonically treated 3~5 minutes, then detains the stewing forging of pot
2 minutes；Then traditional Chinese medicinal ointment concentrate is concentrated to give for the first time；The traditional Chinese medicine powder is prepared as, by acorus graminens soland, mulberry leaf, cassia twig,
Stone-like omphalia is added in pure water together after being respectively washed to be soaked 30 minutes, bath raio 1: 50；Then broken wall treatment and ultrasonically treated, pressure are carried out
Filter is handled, and obtains mixed solution；Handle, be freeze-dried by hypergravity after mixed solution concentration, irradiation sterilization obtains traditional Chinese medicine powder；
Under the conditions of ice-water bath, traditional Chinese medicine powder, the sea-mussel mucin aqueous solution are added in traditional Chinese medicinal ointment concentrate, ultrasonic disperse 3 hours, by the
Secondary concentration, obtains antibacterial surface of a wound ointment；Antibacterial surface of a wound ointment is mixed with phosphate buffer, antibacterial Wound dressing is obtained.
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| CN107929483A (en) * | 2017-03-16 | 2018-04-20 | 耿雪梅 | One kind returns medical cream and its application |
| CN108339144A (en) * | 2018-03-28 | 2018-07-31 | 广西中医药大学 | Adhesive bandage and its preparation method and application |
| CN110841104A (en) * | 2019-10-24 | 2020-02-28 | 广东医科大学 | Preparation method of salidroside-collagen sponge scaffold and application of salidroside-collagen sponge scaffold in skin wound repair |
| EP4117698A4 (en) * | 2020-03-13 | 2024-01-24 | Medihelpline Co., Ltd. | A topical composition comprising an extract of combined herbs comprising longanae arillus for the skin regeneration and the treatment or alleviation of skin wound and the use thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107929483A (en) * | 2017-03-16 | 2018-04-20 | 耿雪梅 | One kind returns medical cream and its application |
| CN108339144A (en) * | 2018-03-28 | 2018-07-31 | 广西中医药大学 | Adhesive bandage and its preparation method and application |
| CN110841104A (en) * | 2019-10-24 | 2020-02-28 | 广东医科大学 | Preparation method of salidroside-collagen sponge scaffold and application of salidroside-collagen sponge scaffold in skin wound repair |
| CN110841104B (en) * | 2019-10-24 | 2021-10-08 | 广东医科大学 | Preparation method of salidroside-collagen sponge scaffold and application of salidroside-collagen sponge scaffold in skin wound repair |
| EP4117698A4 (en) * | 2020-03-13 | 2024-01-24 | Medihelpline Co., Ltd. | A topical composition comprising an extract of combined herbs comprising longanae arillus for the skin regeneration and the treatment or alleviation of skin wound and the use thereof |
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Application publication date: 20170919 |