CN107929483A - One kind returns medical cream and its application - Google Patents

One kind returns medical cream and its application Download PDF

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Publication number
CN107929483A
CN107929483A CN201810012465.7A CN201810012465A CN107929483A CN 107929483 A CN107929483 A CN 107929483A CN 201810012465 A CN201810012465 A CN 201810012465A CN 107929483 A CN107929483 A CN 107929483A
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ointment
extract
medical
cream
minutes
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耿雪梅
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237—Notopterygium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/41—Crassulaceae (Stonecrop family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/69—Polygalaceae (Milkwort family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The invention discloses one kind to return medical cream, is to be used as Chinese medical extract using radix stellariae dichotomae, Chinese mahonia, polygala, radix glycyrrhizae, rhizoma dioscoreae nipponicae, milk thistle, the concentration of Sophora alopecuroide extracting solution；Traditional Chinese medicine powder is used as using the nanoscale extract of matrimony vine, mulberry leaf, notopterygium root, rhodiola root, stone-like omphalia；It is aided with the meglumine adenosine cycle phosphate with hemostasis effectiveness again as hemostat, concentration is obtained after mixing ultrasonic disperse；Wherein the mass fraction ratio of Chinese medical extract, traditional Chinese medicine powder and meglumine adenosine cycle phosphate is 100: 48: 0.1.The invention also discloses application of the above-mentioned ointment on containing graphite Fresh fats layer ointment patch.

Description

One kind returns medical cream and its application
Technical field
The present invention relates to one kind to return medical cream, and in particular to it is a kind of have effects that antibacterial anti hemorrhagic return medicine cream and its containing There is the application on the ointment patch of graphene.
Background technology
Bleeding insult, it is among the people to become red wound, have the characteristics that wound is open, amount of bleeding is big, cause and easily grow carefully Bacterium, lose blood and pain.Quick-acting haemostatic powder is not only needed during treatment, it is also necessary to carry out antibacterial, anti-inflammatory and the treatment of analgesic.General controls The method that treatment method is wrapped up again for smearing ointment, medicinal powder.There is the ointment patch such as adhesive bandage later, the Yunnan such as occurred at present Baiyao adhesive bandage, Bondi Band-Aid etc., can directly quick docile affected part, reach the effect quickly treated.But these are created The ointment used can be pasted it is generally pure Chinese medicinal preparation or pure Western medicine preparation, it is difficult to realizes antibacterial anti-inflammatory at the same time, relieves the pain Efficiency.
Return medicine be part important in motherland's traditional Chinese medicine process, its using Ningxia Chinese medicine as main component, with reference to Other regional medicinal materials, formation possess returning for characteristic and cure back medicine.Return cure back traditional Chinese medicine field of the medicine in China occupy it is important Position.Not only with the therapy for returning doctor's feature, also take full advantage of Ningxia and be located at uplift plateau, the characteristics of sunshine-duration is long, produces Chinese medicine there is the effect of special, the characteristics of foring back medicine.
The present invention is main component using Ningxia Chinese medicine, with reference to other traditional Chinese medicine ingredients and western medicine composition, is developed a kind of special Door is used for time medical cream of antibacterial anti-inflammatory hemostasis.
The content of the invention
It is an object of the invention to provide one kind to return medical cream, is based on Hui Nation In Ningxia doctor's Chinese medicine, matches somebody with somebody with other medicinal materials 5, the effect of antibacterial anti-inflammatory can be reached, relieved the pain.
The invention further relates to the application of above-mentioned time medical cream.
To achieve these goals, the present invention uses following technical scheme：
The present invention's returns medical cream, is carried with radix stellariae dichotomae, Chinese mahonia, polygala, radix glycyrrhizae, rhizoma dioscoreae nipponicae, milk thistle, Sophora alopecuroide Liquid concentration is taken to be used as Chinese medical extract；Traditional Chinese medicine powder is used as using the nanoscale extract of matrimony vine, mulberry leaf, notopterygium root, rhodiola root, stone-like omphalia； It is aided with the meglumine adenosine cycle phosphate with hemostasis effectiveness again as hemostat, concentration is obtained after mixing ultrasonic disperse；Wherein Chinese medicine carries The mass fraction ratio for taking thing, traditional Chinese medicine powder and meglumine adenosine cycle phosphate is 100: 48: 0.1.
Described above returns medical cream, and preferred solution is：
(1) the The Quality of Sliced Herbal Medicine portion rate of the Chinese medical extract is：Radix stellariae dichotomae, Chinese mahonia, polygala, radix glycyrrhizae, wear Mountain dragon, milk thistle, Sophora alopecuroide 100: 68: 54: 89: 41: 26: 10；
(2) the The Quality of Sliced Herbal Medicine portion rate of the nanoscale traditional Chinese medicine powder is：Matrimony vine, mulberry leaf, notopterygium root, rhodiola root, stone-like omphalia For 100: 28: 34: 15: 21.
Returned in described above in medical cream, further priority scheme is：
(1) radix stellariae dichotomae, Chinese mahonia, polygala, radix glycyrrhizae distinguish refluxing extraction by Extraction medium of water, respectively obtain and carry Liquid is taken, it is spare；
(2) milk thistle, Sophora alopecuroide distinguish refluxing extraction by Extraction medium of ethanol, respectively obtain extracting solution, spare；
(3) Extraction medium is used as using the mixed liquor of radix stellariae dichotomae aqueous extract and milk thistle ethanol extract when rhizoma dioscoreae nipponicae is extracted Refluxing extraction is carried out, obtains extracting solution；
(4) Chinese medical extract is that the whole extracting solutions for obtaining above-mentioned (1), (2), (3) mix under room temperature, room temperature It is ultrasonically treated 3~5 minutes, ultrasonic power 200W, frequency 30KHz under normal pressure；Room temperature, which is concentrated under reduced pressure into solid content, to be reached To 60%, it is Chinese medical extract to obtain concentrated medicament.
Returned in described above in medical cream, further priority scheme is：
(1) technique of the water extraction process is：Pure water soaks 30 minutes after the cleaning of raw material medicine materical crude slice, bath raio 1:25, microwave After drying, with boiling water pan feeding, water floods medicine materical crude slice, keeps the temperature reflow treatment 10 minutes under 0.3MPa pressure, then keeps the temperature normal pressure Reflow treatment 15 minutes, phegma natural cooling obtains aqueous extract；
(2) technique of the ethanol extraction process is：Pure water soaks 30 minutes after the cleaning of raw material medicine materical crude slice, bath raio 1:25, it is micro- After ripple drying, with 95% alcohol at normal temperature pan feeding, dosage floods medicine materical crude slice, and it is reflux temperature that temperature is then adjusted in 1 minute, processing 20 Minute, natural cooling obtains ethanol extract；
(3) technique extracted to rhizoma dioscoreae nipponicae is：By above-mentioned radix stellariae dichotomae extracting solution and milk thistle ethanol extract Whole room temperature mixing, room temperature pan feeding, it is reflux temperature that temperature is then adjusted in 15 minutes, is handled 10 minutes, natural cooling obtains Radix stellariae dichotomae/milk thistle/rhizoma dioscoreae nipponicae extracting solution.
Described above returns medical cream, and preferred solution is：
After the matrimony vine, mulberry leaf, notopterygium root, rhodiola root, stone-like omphalia medicine materical crude slice are respectively washed, it is mixed to add in pure water and soaks 30 Minute, bath raio 1: 30；Then broken wall treatment, supersound process, press filtration processing are carried out, obtains mixed solution；After mixed solution concentration Concentrate by hypergravity processing, freeze-drying, irradiation sterilization obtain nanoscale traditional Chinese medicine powder.
The granularity of nanoscale traditional Chinese medicine powder described above is between 90-120 nanometers.
Broken wall treatment described above is under the rotating speed of 38000rpm, and processing time is 10~15 minutes；The ultrasound Processing power selected as 1000W, frequency selection 80KHz, time are elected as 25 minutes；The hypergravity handles selection of speed 25000rpm, concentrate enter flow control in 80mL/min；- 80 DEG C of the freeze-drying temperature selected as, pressure selection For 2Pa, initial evaporation liquid layer thickness 0.5mm, freeze-dried powder state is evaporated to complete.
Time medical cream described above into cream is carried out under the conditions of ice-water bath, the nanoscale traditional Chinese medicine powder that extraction is obtained It is proportionally added into meglumine adenosine cycle phosphate in Chinese medical extract, when ultrasonic disperse 3 is small, ultrasonic power 500W, frequency 60KHz； It is concentrated under reduced pressure into the range of proportion 1.3-1.4, obtains back medical cream.
A kind of application for returning medical cream, is used to prepare antibacterial, the external preparation of hemostasis.
The application for returning medical cream described above, the antibacterial, hemostasis topical agent are ointment patch.
Above-mentioned time ointment patch described in medical patch agent includes back medical cream and mop.The mop includes connecting successively Lining cloth layer, lining bar layer, graphene fiber layer, ointment absorption stratum reticulare and the laminating layer connect.The laminating layer is in its thickness direction On be evenly distributed with some air holes, each air hole runs through the laminating layer.The lining cloth is equipped with some air holes.Institute Medical cream is stated back to be located on ointment absorption stratum reticulare.
Above-mentioned returns in medical patch agent, and the graphene fiber layer includes both ends and pars intermedia, and the graphene is fine The pars intermedia of dimension layer is arranged in juxtaposition in strip；The lining bar layer is two lining bars, using the center line of lining cloth layer along the longitudinal direction as Benchmark, described two lining bars set up separately in lining cloth layer center line both sides；The ointment adsorption net is cotton fabric, silk fabrics, staple are knitted Thing, polycarbonate fabric either one of dacron fabric or blended fabric；The lining bar is in the arc of crescent shape Shape；The pass of the air hole is triangular in shape, one or more combinations in circular and diamond shape.
The effect of the present invention is as follows：
1. in ointment disclosed by the invention, especially use nanoscale traditional Chinese medicine powder to be mixed with Chinese medical extract first, and Combination based on nanoscale traditional Chinese medicine powder and extract, the advantage for playing respective Chinese medicine also solve the problem of each influencing each other. For example mulberry leaf can neutralize the hypotoxicity of stone-like omphalia, the cooperation of notopterygium root, rhodiola root can improve oxidation resistance and detumescence effect, Chinese mahonia can then neutralize radix stellariae dichotomae, Sophora alopecuroide it is cold, radix glycyrrhizae and polygala compatibility can slow down pain, and combine rhizoma dioscoreae nipponicae can Detumescence.Western medicine composition meglumine adenosine cycle phosphate is equipped with to combine to form ointment to body as hemostat, various medicinal material active ingredients Outer broken wound has good efficacy.
2nd, the present invention uses microwave drying Chinese medicine, rather than conventional electrical heating, it is ensured that and effective component of chinese medicine is not destroyed, It is favourable for subsequent extracted, it is easier in so that and the microstructure after microwave treatment inside medicinal material can change a lot Medicine component rapidly separates out.By extract respectively avoid extraction when each active ingredient interaction and cause drug effect lose or Generation side effect, while using the means extracted at the same time when extracting the active ingredient of rhizoma dioscoreae nipponicae, neutralization radix stellariae dichotomae/milk thistle/ The toxic component of rhizoma dioscoreae nipponicae, the plaster toxicity obtained from is low, good effect.
3rd, the present invention mixes traditional Chinese medicine powder and extracting solution at low temperature, avoids the reaction of active ingredient from each other, also keeps away The loss of drug effect is exempted from, the ointment of preparation is maintained at low temperature, takes out when in use, can be with reference to the effect of through hole and body temperature So that the quick backheat of ointment and playing a role.
4th, the present invention can refine the precipitation of effective component of chinese medicine using broken wall treatment from cell level, with reference to supersound process, Purpose is not traditional raising dispersiveness, but further ultrasonication particle, the crushing effect of broken wall treatment is improved, so as to carry High removal of impurity simultaneously improves pulverization process effect.
5th, the present invention utilizes high-gravity rotating bed, under hypergravity effect, Traditional Chinese drug mixture is handled so that Chinese medicine Nucleation, forms nanoscale product, solves the problems such as prior art Chinese medicine particle is excessive, is unfavorable for effect plays.And existing skill Report of the hypergravity to polymer treatment is had no in art, and since polymer nucleation process is there is no reactivity, and polymerize It is thing toughness itself, viscosity, all more special into nuclearity, it is considered that to be not suitable for being received using hypergravity method processing polymer Rice product, in pharmaceutical field using less.The inventive method achieves the breakthrough to this field.
6th, the ointment patch for returning medical cream application of the invention, due to being rationally provided with graphene fiber layer, in laminating layer On offer some air holes, so as to effectively suppress because of ointment with contact human skin and may be produced exposed to the external world Raw bacterium；On the one hand the air permeability of ointment adsorption net of the present invention is beneficial to the loading effect of ointment on it, more important is profit During medical ointment plaster use, the exchange of gas molecule and hydrone, avoids moisture, plays and lays the first stone for pharmacological property.
7th, being set in mop for the invention serves as a contrast bar, has crucial work to the mechanical property for lifting mop by limiting With the contraction of mop being avoided, also beneficial to load of the mop to medicine；Graphene fiber layer can be obtained by fiber impregnation graphene Arrive, there is physical sterilization deodorization, natural absorbing sweat taste removal, spontaneous heating, far infrared microcirculation, after being combined with ointment, can have Effect reduces the allergy rate of plaster, solves the auxiliary effect such as fuel factor that plaster needs.
Brief description of the drawings
Fig. 1 is the cross-sectional view of the antibacterial ointment Tobe of patch embodiment one of the present invention；
Fig. 2 is the laminating layer planar structure schematic diagram of patch embodiment one of the present invention；
Fig. 3 is the graphene fiber layer plane structure diagram of patch embodiment one of the present invention；
Fig. 4 is the lining bar flat shape and arrangement schematic diagram of patch embodiment one of the present invention；
Wherein, 1 is lining cloth；2 be lining bar；3 be graphene fiber layer；4 adsorb stratum reticulare for ointment；5 be laminating layer；6 be patch Close layer air hole；7 be lining cloth air hole；30 be graphene fiber layer both ends；31 be graphene fiber layer pars intermedia；During 32 are Between portion's horizontal fibre bar；33 be gap；34 be both ends longitudinal fiber bar.
Embodiment
Technical scheme is further illustrated with reference to embodiment, these embodiments are merely to illustrate this hair It is bright, the scope of but do not limit the invention in any way.
(I) ointment prepares embodiment
The present invention's returns medical cream, is carried with radix stellariae dichotomae, Chinese mahonia, polygala, radix glycyrrhizae, rhizoma dioscoreae nipponicae, milk thistle, Sophora alopecuroide Liquid is taken to be used as Chinese medical extract after concentrating；With matrimony vine, mulberry leaf, notopterygium root, rhodiola root, stone-like omphalia extraction nanoscale traditional Chinese medicine powder；With ring phosphorus Adenosine Portugal amine as hemostat, be made after mixed processing.
First, first have to prepare extraction liquid, weigh respectively 100 grams of radix stellariae dichotomae, 68 grams of Chinese mahonias, 54 grams of polygalas, 89 grams Radix glycyrrhizae, 41 grams of rhizoma dioscoreae nipponicaes, 26 grams of milk thistles, 10 grams of Sophora alopecuroide prepared slices of Chinese crude drugs are spare.
(1) radix stellariae dichotomae, Chinese mahonia, polygala, radix glycyrrhizae, rhizoma dioscoreae nipponicae, milk thistle, the Sophora alopecuroide prepared slices of Chinese crude drugs are clear with clear water respectively Wash, then be separately added into pure water and soak, add water water temperature to be room temperature, bath raio 1:25, after respectively soaking 30 minutes, take out go forward side by side respectively Row microwave drying treatment, obtains the dry radix stellariae dichotomae of cleaning, Chinese mahonia, polygala, radix glycyrrhizae, rhizoma dioscoreae nipponicae, milk thistle, Sophora alopecuroide drink Piece.
(2) radix stellariae dichotomae aqueous extract is extracted：Using water as Extraction medium, the Yin Chai for the cleaning drying that above-mentioned steps are obtained Hu medicine materical crude slice is added in return channel, adds the water purification of boiling, and water floods medicine materical crude slice, and insulation is kept at the pressure reflux of 0.3MPa Reason 10 minutes, then keeps the temperature atmospheric pressure reflux and handles 15 minutes, obtain phegma, treat phegma natural cooling, obtain radix stellariae dichotomae water Reflux extracting liquid, it is spare.
(3) Chinese mahonia aqueous extract is extracted：Using water as Extraction medium, dry ten are cleaned by what above-mentioned steps obtained Big contribution medicine materical crude slice is added in return channel, adds the water purification of boiling, and water floods medicine materical crude slice, and insulation keeps the pressure of 0.3MPa to return Stream process 10 minutes, then keeps the temperature atmospheric pressure reflux and handles 15 minutes, obtain phegma, treat phegma natural cooling, it is big to obtain ten Contribution water reflux extracting liquid, it is spare.
(4) polygala aqueous extract is extracted：Using water as Extraction medium, the polygala for the cleaning drying that above-mentioned steps obtain is drunk Piece is added in return channel, adds the water purification of boiling, and water floods medicine materical crude slice, and insulation keeps the pressure reflow treatment 10 of 0.3MPa Minute, then keep the temperature atmospheric pressure reflux and handle 15 minutes, obtain phegma, treat phegma natural cooling, obtain the reflux of polygala water and carry Liquid is taken, it is spare.
(5) radix glycyrrhizae aqueous extract is extracted：Using water as Extraction medium, the radix glycyrrhizae for the cleaning drying that above-mentioned steps obtain is drunk Piece is added in return channel, adds the water purification of boiling, and water floods medicine materical crude slice, and insulation keeps the pressure reflow treatment 10 of 0.3MPa Minute, then keep the temperature atmospheric pressure reflux and handle 15 minutes, obtain phegma, treat phegma natural cooling, obtain liquorice beverage reflux and carry Liquid is taken, it is spare.
(6) milk thistle ethanol extract is extracted：Using 95% ethanol as Extraction medium, dry milk thistle will be cleaned and drunk Piece adds return channel, then adds room temperature ethanol, and for ethanol consumption to flood medicine materical crude slice, heating reaches atmospheric pressure reflux temperature in 1 minute, Keep the temperature and handle 20 minutes under normal pressure, obtain phegma, treat phegma natural cooling, obtain milk thistle refluxing extraction Liquid, it is spare.
(7) Sophora alopecuroide ethanol extract is extracted：Using 95% ethanol as Extraction medium, dry Sophora alopecuroide will be cleaned and drunk Piece adds return channel, then adds room temperature ethanol, and to flood medicine materical crude slice, heating makes to reach atmospheric pressure reflux temperature in one minute ethanol consumption Degree, keeps the temperature and handles 20 minutes under normal pressure, obtain phegma, treat phegma natural cooling, obtains Sophora alopecuroide reflux Extracting solution, it is spare.
(8) rhizoma dioscoreae nipponicae extracting solution is extracted：Obtained radix stellariae dichotomae aqueous extract and obtained milk thistle ethanol extract is complete Portion carries out room temperature mixing, as Extraction medium.Dry rhizoma dioscoreae nipponicae medicine materical crude slice will be cleaned to add in return channel, add above-mentioned mixing Medium.Atmospheric pressure reflux temperature was warming up in 15 minutes, insulation flows back 10 minutes, and radix stellariae dichotomae, milk thistle are contained in the extracting solution It is spare after natural cooling with the active ingredient of rhizoma dioscoreae nipponicae.
(9) mixed extract and concentrate：Three parts of aqueous extracts, a ethanol extract and mixed extract will be obtained in normal The lower mixing of temperature, is ultrasonically treated 3 minutes, the use of ultrasonic power is 200 watts, frequency is 30 kilo hertzs；The purpose of supersound process is normal The lower sufficiently mixing of temperature.Then be concentrated under reduced pressure, to be concentrated to give solid content be 60% Chinese medical extract；Quantities received is 150 grams.The extract is spare as Chinese medical extract.
2nd, Nano Chinese medicine powder is prepared
(1) 100 grams of prepared slices of Chinese crude drugs matrimony vine is weighed respectively；28 grams of mulberry leaf；34 grams of notopterygium root；15 grams of rhodiola root；21 grams of stone-like omphalia, clearly Water room temperature is respectively washed totally, then adds soak at room temperature 30 minutes in pure water together, and bath raio 1: 30, i.e. amount of water are 5940 millis Rise.
(2) water of the above-mentioned prepared slices of Chinese crude drugs and immersion is together put into wall-breaking machine and carries out broken wall treatment, the time of broken wall treatment For 10 minutes, rotating speed 38000rpm.
(3) then the mixture liquid through broken wall treatment is ultrasonically treated 25 minutes, power 1000W, frequency 80KHz again.
(4) and then again press filtration processing is carried out through filter press, obtains mixed liquor.
(5) mixed solution obtains the concentrate that density is 1.1-1.2 after concentration is depressurized.
(6) concentrate carries out hypergravity processing, and the rotating speed of hypergravity processing is 25000rpm, concentrate into flow quantity control System is in 80mL/min.
(7) it will be evaporated by the concentrate freezing vacuum of hypergravity processing, keep evaporation liquid layer thickness 0.5mm to be freezed Vacuum drying, the temperature of freeze-drying is -80 DEG C, vacuum 2Pa.Then radiation sterilizing is carried out again, obtains traditional Chinese medicine powder 60 Gram.Nanoscale traditional Chinese medicine powder is made between 90-120 nanometers in the particle diameter of the traditional Chinese medicine powder obtained at this time.
3rd, into cream：Under the conditions of ice-water bath, that is, the low temperature of zero degrees celsius is kept, by nanoscale traditional Chinese medicine powder obtained above 48 grams, 0.1 gram of meglumine adenosine cycle phosphate add in 100 grams of Chinese medical extract, be maintained under the low temperature environment, ultrasonic disperse 3 is small When, sonification power 500W, frequency 60KHz；Again by decompression room temperature concentration, 120 grams can be obtained, receives to obtain thing at this time For thick paste state, density is between 1.3-1.4, color sepia, is that the present invention returns medical cream.
Medical cream Application Example is returned, the ointment patch returned in medical cream application of the invention, is by the above-mentioned of the present invention Return medicine ointment and ointment patch is made, to realize the function of antibacterial anti hemorrhagic.
(II) ointment Application Example：
A kind of return is made medical cream and ointment mop are returned made from medical cream posts agent, including ointment preparation embodiment. Ointment swab construction is shown in attached drawing 1-4, and ointment mop includes being close to the lining cloth 1 of connection, lining bar 2, graphene fiber layer 3, medicine successively Cream adsorbs stratum reticulare 4 and laminating layer 5 is formed.Wherein it is close to connect between neighboring layers, connection mode can be bonding, pressing It is close to connection mode etc. various, can also be used as other connection modes.
Innermost layer of the laminating layer 5 as mop, that is, skin contacting adhesive layer, it is desirable to which there is certain gas permeability and cream Medicine penetrates permeability, is evenly distributed with some air holes 6 in the thickness direction thereof, and each air hole 6 runs through the fitting Layer 5, so that ointment adsorbs stratum reticulare 4 and connected with extraneous (patient skin) by some air holes 6.Laminating layer 5 is adsorbed with ointment Stratum reticulare 4 is close to connect by the adhesive bond of ointment in itself.
Ointment absorption stratum reticulare 4 is the ointment carrier of mop of the present invention, in the present embodiment, the ointment absorption stratum reticulare 4 Intersected by the silk fiber of warp and weft shape and be made.It is the validity part of ointment, there is stronger ointment suction-operated, make Used time ointment is by the viscosity absorption of itself on the layer.It is located at the outside of laminating layer 5.Certain ointment absorption stratum reticulare 4 also may be used To use cotton fabric, science fabric such as polycarbonate fabric or dacron fabric and mixed fiber fabric It is made.
The graphene fiber layer 3 be arranged on ointment absorption stratum reticulare 4 outside, can also by ointment in itself viscosity with Ointment absorption stratum reticulare 4 is close to connect.The graphene fiber layer 3 includes both ends 30 and pars intermedia 31, the graphene fiber The pars intermedia 31 of layer 3 is in strip arranged for interval arranged side by side, and graphene fiber bar 32 is arranged in horizontal interval, and forms gap in centre 33.The both ends of the ribbon 32 of pars intermedia 31 connect the both ends 30 of the black alkene fibrous layer 3 respectively, both ends 30 then by positioned at The longitudinal fiber bar 34 of both sides is formed, and a kind of strip grid structure is integrally formed.
Described two linings bars 2 are horizontally arranged between lining cloth 1 and graphene fiber layer 3, the graphene fiber layer 3 with Lining bar 2 fixed form be：Lining bar 2 by being close to be fixedly connected between binding material and the downside of graphene fiber layer 3, or Person is to be close to connect by jointing material bonding between the lining cloth 1 and graphene fiber layer 3, while lining bar 2 is fixed on lining Between cloth 1 and graphene fiber layer 3.By lining cloth 1 along the longitudinal centerline on the basis of, described two lining bars 2 set up separately in lining cloth 1 Heart line both sides.The lining bar 2 is in the arc of crescent shape, and two lining bars 2 are arranged oppositely, and form a not closed flabellum profile knot Structure.
The lining cloth 1 is equipped with some air holes 7, and the pass of air hole 7 is rounded, certainly, air hole 7 is set is in Single shape processing is more convenient, and still, it is also enforceable that air hole 7 is arranged to various shapes.
In above-mentioned mop, the ointment that ointment of the present invention preparation embodiment is obtained is with equally distributed absorption in ointment On adsorption layer.
(III) ointment comparative example one：Ointment is in addition to without meglumine adenosine cycle phosphate, remaining is as ointment embodiment of the present invention.
(IV) ointment comparative example two：When prepared by ointment, matrimony vine, mulberry leaf, notopterygium root, rhodiola root, stone-like omphalia are carried with water reflux respectively Take, prepare extract, do not use the form of Nano Chinese medicine powder, as remaining.
(V) ointment comparative example three：Whole Chinese medicines are used boils extraction process using conventional, and the time adds as 5 times, remaining one Sample.
Corresponding comparative example ointment is made according to the ointment dosage and Tobe of embodiment in the ointment of above three comparative example Patch, carries out contrast test.
(VI) ointment patch comparative example：Compared with ointment patch embodiment, mop is free of graphene fiber layer, remaining one Sample.Contrast test.
Ointment note contrasts sterilization test method：Reference《Disinfectant sterilization test specification》 (Q/KM-ZJ-2008).
1st, the equal suspension of standard of the corresponding strain of experiment is made；
2nd, multiple 1 cm square shape non-woven fabrics bacterium pieces are made；
3rd, each bacterium piece is coated with bacterium piece with 10 microlitres of standard bacteria suspensions, dries in the shade；
4th, the ointment note of above-mentioned each embodiment, comparative example is distinguished into docile and applies bacterium non-woven fabrics bacterium on piece to corresponding；Together When with non-woven fabrics replace the ointment note of embodiment and comparative example to do blank test.
5th, plaster and blank test non-woven fabrics are taken when 24 is small off；
6th, bacterium piece is put into quantitative aseptic water and cleaned；
7th, amount containing bacterium number in the sterile water of cleaning is measured；
8th, the ratio with experiment with the amount containing bacterium number in amount containing bacterium number in cleaning sterile water and blank experiment cleaning sterile water Value carries out percentage contrast, ratio A.24 it is small when sterilizing rate be 1-A.
Repeat above-mentioned experiment three times, be averaged.
The result of above-mentioned ointment patch contrast test：
(II) patch of ointment Application Example, antibacterial tests result：Counting shows and is sterilized when it is small to Escherichia coli 24 Rate is 99.99%, and sterilizing rate is 99.92% when small to staphylococcus aureus 24, and sterilizing rate is when small to Candida albicans 24 99.96%；Kill rate is 8% when small to L929 cells 24.For stopping for 1 centimetre or so of wound (20 people of volunteer) of adult The blood time, average out to 24.4 seconds, minimum 15 seconds, most 45 seconds.It is shown in Table one.
(III) the ointment patch of ointment comparative example one, antibacterial tests result：Counting shows and is killed when it is small to Escherichia coli 24 Bacterium rate is 99.88%, and sterilizing rate is 99.82% when small to staphylococcus aureus 24, sterilizing rate when small to Candida albicans 24 For 99.89%；Kill rate is 8% when small to L929 cells 24；For 1 centimetre or so of wound (20 people of volunteer) of adult Average bleeding stopping period is more than more than 2 minutes, wherein 4 people's bleeding stopping periods were more than 4 minutes.It is shown in Table two.
(IV) the ointment patch of ointment comparative example two, antibacterial tests result：Counting shows and is killed when it is small to Escherichia coli 24 Bacterium rate is 98.25%, and sterilizing rate is 98.34% when small to staphylococcus aureus 24, sterilizing rate when small to Candida albicans 24 For 98.14%；Kill rate is 26% when small to L929 cells 24；For 1 centimetre or so of wound (20 people of volunteer) of adult Average bleeding stopping period is 57 seconds, minimum 36 seconds, most 92 seconds.See mark three.
(V) the ointment patch of ointment comparative example three, antibacterial tests result：Counting shows and is killed when it is small to Escherichia coli 24 Bacterium rate is 99.19%, and sterilizing rate is 99.24% when small to staphylococcus aureus 24, sterilizing rate when small to Candida albicans 24 For 99.08%；Kill rate is 12% when small to L929 cells 24；For 1 centimetre or so of wound (20 people of volunteer) of adult Average bleeding stopping period is 88.7 seconds, minimum 55 seconds, most 122 seconds.It is shown in Table four.
(VI) ointment patch comparative example ointment patch, antibacterial tests result：Counting shows and is killed when it is small to Escherichia coli 24 Bacterium rate is 99.59%, and sterilizing rate is 99.47% when small to staphylococcus aureus 24, sterilizing rate when small to Candida albicans 24 For 99.52%；Kill rate is 9% when small to L929 cells 24；For being averaged for 1 centimetre or so of wound (volunteer) of adult Bleeding stopping period is 43 seconds, minimum 25 seconds, most 7 seconds.It is shown in Table five.
Being seen by above-mentioned contrast test to illustrate, the effective percentage of ointment of the invention is far above to be made using conventional method Ointment.Patch is made far above conventional method in the effect of the ointment patch of the present invention.
Table one (ointment patch bleeding stopping period statistics of the present invention)
Sequence number Position Wound size Time
1 Upper arm 0.8 17
2 Forearm 0.9 15
3 The back of the hand 0.9 15
4 Belly 0.8 25
5 Back 0.7 27
6 Upper arm 1.0 31
7 Shank 1.0 45
8 Thigh 1.1 17
9 Buttocks 1.0 22
10 Buttocks 1.2 20
11 Instep 0.9 31
12 The back of the hand 0.9 18
13 Forearm 0.8 18
14 Wrist 0.8 15
15 Shirtfront 0.9 27
16 Low back 1.2 29
17 Knee 1.0 44
18 The back of the hand 0.9 35
19 The back of the hand 0.9 21
20 Forearm 0.8 16
It is total/average 488/24.4
Table two (the ointment patch bleeding stopping period of comparative example one)
Sequence number Position Wound size Time
1 The back of the hand 1.0 125
2 Back 0.9 197
3 Belly 1.1 Disregard more than four minutes
4 Forearm 0.8 Disregard more than four minutes
5 The back of the hand 0.7 190
6 Upper arm 0.8 186
7 Shank 0.9 155
8 Buttocks 0.9 144
9 Upper arm 0.8 165
10 Buttocks 0.8 177
11 Shirtfront 0.9 235
12 Instep 1.1 189
13 Forearm 1.0 199
14 Low back 0.7 122
15 Knee 0.9 143
16 Forearm 0.9 156
17 The back of the hand 1.1 Disregard more than four minutes
18 Thigh 0.9 Disregard more than four minutes
19 The back of the hand 1.2 211
20 Wrist 0.8 216
It is total/average Do not calculate
Table three (the ointment patch bleeding stopping period of comparative example two)
Sequence number Position Wound size Time
1 Belly 1.0 92
2 Upper arm 0.9 37
3 The back of the hand 1.2 39
4 Forearm 0.8 88
5 Shank 0.7 65
6 Back 0.9 44
7 Buttocks 1.0 55
8 Buttocks 0.8 37
9 Upper arm 0.9 49
10 The back of the hand 0.8 65
11 Thigh 0.9 71
12 Instep 1.0 82
13 Knee 1.0 57
14 Forearm 0.8 62
15 Low back 0.9 36
16 Forearm 0.9 82
17 The back of the hand 1.2 44
18 Shirtfront 0.9 56
19 The back of the hand 1.0 42
20 Wrist 0.8 37
It is total/average 1140/57
Table four (the ointment patch bleeding stopping period of comparative example three)
Sequence number Position Wound size Time
1 Belly 1.0 120
2 Back 0.9 108
3 The back of the hand 1.1 55
4 Forearm 0.8 59
5 Shank 0.7 62
6 Upper arm 0.8 89
7 Buttocks 1.0 110
8 The back of the hand 0.9 67
9 Upper arm 0.9 65
10 Buttocks 0.8 93
11 Thigh 0.9 78
12 Instep 1.2 88
13 Forearm 1.0 99
14 Forearm 0.8 122
15 Knee 0.9 100
16 Low back 0.9 58
17 The back of the hand 1.2 62
18 Shirtfront 0.8 73
19 The back of the hand 1.0 77
20 Wrist 0.8 84
It is total/average 1669/83.45
Table five (ointment patch comparative example bleeding stopping period)
Sequence number Position Wound size Time
1 Shank 1.0 25
2 Buttocks 0.9 36
3 Back 1.1 45
4 Forearm 0.8 43
5 The back of the hand 0.7 37
6 Upper arm 0.8 29
7 The back of the hand 0.9 31
8 Belly 0.9 35
9 Upper arm 0.8 42
10 Buttocks 0.9 33
11 Shirtfront 0.9 44
12 Instep 1.2 32
13 Wrist 1.0 76
14 The back of the hand 0.7 56
15 Knee 0.8 63
16 Forearm 0.9 55
17 Thigh 1.1 47
18 Forearm 0.9 58
19 The back of the hand 1.1 39
20 Low back 0.8 34
It is total/average 860/43

Claims (12)

1. one kind returns medical cream, it is characterised in that：Containing with radix stellariae dichotomae, Chinese mahonia, polygala, radix glycyrrhizae, rhizoma dioscoreae nipponicae, milk thistle, The Chinese medical extract of Sophora alopecuroide water reflux extracting liquid concentration；With in matrimony vine, mulberry leaf, notopterygium root, rhodiola root, the extraction of stone-like omphalia nanoscale Medicinal powder；As hemostat meglumine adenosine cycle phosphate.
2. according to claim 1 time medical cream, it is characterised in that：The medical cream that returns is by above-mentioned traditional Chinese medicine extraction Thing, traditional Chinese medicine powder and meglumine adenosine cycle phosphate concentrate after mixing ultrasonic disperse to be made；Wherein Chinese medical extract, traditional Chinese medicine powder and ring phosphorus gland The mass fraction ratio of glycosides Portugal amine is 100: 48: 0.1.
3. according to claim 1 or 2 time medical cream, it is characterised in that：
（1）The The Quality of Sliced Herbal Medicine portion rate of the Chinese medical extract is：Radix stellariae dichotomae, Chinese mahonia, polygala, radix glycyrrhizae, rhizoma dioscoreae nipponicae, Milk thistle, Sophora alopecuroide 100: 68: 54: 89: 41: 26: 10；
（2）The The Quality of Sliced Herbal Medicine portion rate of the nanoscale traditional Chinese medicine powder is：Matrimony vine, mulberry leaf, notopterygium root, rhodiola root, stone-like omphalia 100 ∶28∶34∶15∶21。
4. medical cream is returned according to claim 1-3 any one of them, it is characterised in that：
（1）The radix stellariae dichotomae, Chinese mahonia, polygala, radix glycyrrhizae distinguish refluxing extraction by Extraction medium of water, respectively obtain extraction Liquid, it is spare；
（2）Milk thistle, Sophora alopecuroide distinguish refluxing extraction by Extraction medium of ethanol, respectively obtain extracting solution, spare；
（3）Carried out when rhizoma dioscoreae nipponicae is extracted using the mixed liquor of radix stellariae dichotomae aqueous extract and milk thistle ethanol extract as Extraction medium Refluxing extraction, obtains extracting solution, spare；
（4）The Chinese medical extract is will be above-mentioned（1）、（2）、（3）Obtained whole extracting solutions mix under room temperature, normal temperature and pressure It is ultrasonically treated 3~5 minutes, sonification power 200W, frequency 30KHz；Room temperature be concentrated under reduced pressure into solid content be to More than 60%, it is Chinese medical extract to obtain concentrated medicament.
5. according to claim 4 time medical cream, it is characterised in that：
（1）The technique of the water extraction process is：Pure water soaks 30 minutes after the cleaning of raw material medicine materical crude slice, bath raio 1:25, microwave drying Afterwards, medicine materical crude slice is flooded with boiling water pan feeding, water, keeps the temperature reflow treatment 10 minutes under 0.3MPa pressure, then normal pressure heat-insulating flows back Processing 15 minutes, collects phegma natural cooling and obtains aqueous extract；
（2）The technique of the ethanol extraction process is：Pure water soaks 30 minutes after the cleaning of raw material medicine materical crude slice, bath raio 1:25, microwave is done Dry, with 95% alcohol at normal temperature pan feeding, amount of alcohol floods medicine materical crude slice, and it is atmospheric pressure reflux temperature that temperature is then adjusted in 1 minute, processing 20 Minute, collect phegma natural cooling and obtain ethanol extract；
（3）The technique extracted to rhizoma dioscoreae nipponicae is：Take liquid and milk thistle ethanol extract complete above-mentioned radix stellariae dichotomae water lift Portion's room temperature mixing, room temperature pan feeding, then adjusts the temperature to atmospheric pressure reflux temperature in 15 minutes, handle 10 minutes, natural cooling obtains To radix stellariae dichotomae/milk thistle/rhizoma dioscoreae nipponicae extracting solution.
6. return medical cream according to claim 1-5 any one, it is characterised in that：It is the matrimony vine, mulberry leaf, notopterygium root, red Red-spotted stonecrop, stone-like omphalia medicine materical crude slice mix after being respectively washed, and add in pure water soak 30 minutes together, bath raio 1: 30；Then carry out at broken wall Reason, be ultrasonically treated, press filtration processing, obtains mixed solution；Again by hypergravity processing, freeze-drying, spoke after mixed solution concentration Nanoscale traditional Chinese medicine powder is obtained according to sterilizing；The granularity of the nanoscale traditional Chinese medicine powder is between 90-120 nanometers.
7. according to claim 6 time medical cream, it is characterised in that：The broken wall treatment is the rotating speed in 38000rpm Under, processing time is 10~15 minutes；The sonification power selected as 1000W, frequency selection 80KHz, time elect 25 as Minute；The hypergravity processing selection of speed is 25000rpm, and concentrate enters flow control in 80mL/min；The freezing - 80 DEG C of drying temperature selected as, pressure selected as 2Pa, initial evaporation liquid layer thickness 0.5mm.
8. return medical cream according to claim 1-7 any one, it is characterised in that：Under the conditions of ice-water bath, it will extract Obtained nanoscale traditional Chinese medicine powder and meglumine adenosine cycle phosphate is proportionally added into Chinese medical extract, when ultrasonic disperse 3 is small, ultrasonic power For 500W, frequency 60KHz；Room temperature is concentrated under reduced pressure to give back medical cream, and ointment density is between 1.3-1.4.
A kind of 9. application for returning medical cream as any one of claim 1-8, it is characterised in that：It is used to prepare anti- Bacterium, the external preparation of hemostasis.
10. the application of according to claim 9 time medical cream, it is characterised in that：The antibacterial, hemostasis topical agent are medicine Patch agent.
11. the application of according to claim 10 time medical cream, it is characterised in that：The ointment patch includes back medical cream And mop；The mop includes sequentially connected lining cloth layer, lining bar layer, graphene fiber layer, ointment absorption stratum reticulare and patch Close layer；The laminating layer is evenly distributed with some air holes in the thickness direction thereof, and each air hole runs through the laminating layer； The lining cloth is equipped with some air holes；Described time medical cream is located on ointment absorption stratum reticulare.
12. the application of according to claim 11 time medical cream, it is characterised in that：The graphene fiber layer includes both ends Portion and pars intermedia, the pars intermedia of the graphene fiber layer are arranged in juxtaposition in strip；The lining bar layer is two lining bars, with lining cloth On the basis of the center line of layer along the longitudinal direction, described two lining bars set up separately in lining cloth layer center line both sides；The ointment adsorption net Either one of dacron fabric or blended knitted for cotton fabric, silk fabrics, staple fabric, polycarbonate fabric Thing；The lining bar is in the arc of crescent shape；The pass of the air hole is triangular in shape, the one or more in circular and diamond shape Combination.
CN201810012465.7A 2017-03-16 2018-01-05 One kind returns medical cream and its application Pending CN107929483A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106265822A (en) * 2016-10-10 2017-01-04 广东省中医院 There are anti-inflammation raw myofunctional Mahonia bealei (Fort.) Carr. extract, preparation method and applications
CN107126540A (en) * 2017-04-26 2017-09-05 苏州益可泰电子材料有限公司 A kind of hemostatic and antibacterial ointment, medicine and preparation method thereof
CN107174602A (en) * 2017-03-26 2017-09-19 苏州益可泰电子材料有限公司 A kind of antibacterial surface of a wound ointment and patch, antibacterial Wound dressing
CN107412520A (en) * 2017-04-26 2017-12-01 苏州益可泰电子材料有限公司 A kind of antibacterial anti hemorrhagic ointment, medicine and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106265822A (en) * 2016-10-10 2017-01-04 广东省中医院 There are anti-inflammation raw myofunctional Mahonia bealei (Fort.) Carr. extract, preparation method and applications
CN107174602A (en) * 2017-03-26 2017-09-19 苏州益可泰电子材料有限公司 A kind of antibacterial surface of a wound ointment and patch, antibacterial Wound dressing
CN107126540A (en) * 2017-04-26 2017-09-05 苏州益可泰电子材料有限公司 A kind of hemostatic and antibacterial ointment, medicine and preparation method thereof
CN107412520A (en) * 2017-04-26 2017-12-01 苏州益可泰电子材料有限公司 A kind of antibacterial anti hemorrhagic ointment, medicine and preparation method thereof

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