CN106172547A - A kind of operating room disinfection sanitizer and preparation method - Google Patents
A kind of operating room disinfection sanitizer and preparation method Download PDFInfo
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Abstract
The invention discloses a kind of operating room disinfection sanitizer and preparation method, belong to the field of Chinese medicines；The raw material of disinfection sanitizer effective ingredient of the present invention forms and parts by weight are: Fructus nephelii topengii 26～50 parts, Herba tiarellae polyphyllae 26～50 parts, Herba Ajugae Lupulinae 25～49 parts, Herba Boenninghauseniae Albiflorae 24～48 parts, poinsettia 24～48 parts, Folium Phyllanthi 24～48 parts, Bulbus Allii 23～47 parts, Radix Lespedezae Chinensis 22～46 parts, Flos Caryophylli 22～46 parts, Xian 21～45 parts, Bulbus Cardiocrini Cathayani 20～44 parts, Radix embeliae laetae 20～44 parts, thunderclap pasture and water 20～44 parts and Radix panici repentics 19～42 parts；Disinfection sanitizer effect of the present invention is notable, use safety, nonirritant, with low cost, can effectively kill virus, antibacterial, fungus and pathogen, it is to avoid pathogenic bacteria aerial propagation, also reduce the generation of postoperative infection simultaneously, improve the safety of operation, be highly suitable for large-scale promotion in the operating room of hospital and use.
Description
Art
The present invention relates to the field of Chinese medicines, particularly relate to a kind of operating room disinfection sanitizer and preparation method.
Background technology
Operating room is the place rescued patient and treat, owing under surgical environments, the organ of patient, tissue are understood sudden and violent
Being exposed in environment, therefore the cleanliness levels of operating room directly affects operation safety and therapeutic effect, therefore operating room environment pair
Sterilizing operation and aseptic level have the highest requirement, and the sterilizing medicine that operating room uses is made up of chemicals mostly,
The chemicals of this kind has serious zest to human body skin, is unfavorable for the carrying out of operation, and even causing of having is serious
Anaphylaxis, if sterilizing is the most thorough, it is easy to make patient wound suppurate, the state of an illness of patient can be had a strong impact on, disappear at present
Venom is varied, but great majority are both for human body antibacterial aspect and configure, it is impossible to medical personnel itself and operation
Room carries out omnibearing thorough disinfection；Room sterilization sterilization mainly eliminates a series of antibacterial and pathogen is the most golden yellow
Color staphylococcus, escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, proteus vulgaris etc., provide good for operating room
Environment.Therefore, finding a kind of efficient sterilization disinfectant is all very important to operating room technician and patient.
Summary of the invention
The invention provides a kind of operating room disinfection sanitizer and preparation method；Disinfection sanitizer effect of the present invention shows
Write, use safety, nonirritant, with low cost, can effectively kill virus, antibacterial, fungus and pathogen, it is to avoid pathogenic bacteria is at sky
Propagation in gas, also reduces the generation of postoperative infection simultaneously, improves the safety of operation, is highly suitable for the operation of hospital
In room, large-scale promotion uses.
For achieving the above object, technical scheme is implemented as follows:
A kind of operating room disinfection sanitizer, makes raw material composition and the parts by weight of described disinfection sanitizer effective ingredient
For:
Fructus nephelii topengii 26～50 parts, Herba tiarellae polyphyllae 26～50 parts, Herba Ajugae Lupulinae 25～49 parts, Herba Boenninghauseniae Albiflorae 24～48 parts, poinsettia
24～48 parts, Folium Phyllanthi 24～48 parts, Bulbus Allii 23～47 parts, Radix Lespedezae Chinensis 22～46 parts, Flos Caryophylli 22～46 parts, Xian 21～
45 parts, Bulbus Cardiocrini Cathayani 20～44 parts, Radix embeliae laetae 20～44 parts, thunderclap pasture and water 20～44 parts and Radix panici repentics 19～42 parts.
Make described disinfection sanitizer effective ingredient raw material composition and parts by weight be:
Fructus nephelii topengii 30～46 parts, Herba tiarellae polyphyllae 30～46 parts, Herba Ajugae Lupulinae 29～45 parts, Herba Boenninghauseniae Albiflorae 28～44 parts, poinsettia
28～44 parts, Folium Phyllanthi 28～44 parts, Bulbus Allii 27～43 parts, Radix Lespedezae Chinensis 26～42 parts, Flos Caryophylli 26～42 parts, Xian 25～
41 parts, Bulbus Cardiocrini Cathayani 24～40 parts, Radix embeliae laetae 24～40 parts, thunderclap pasture and water 24～40 parts and Radix panici repentics 22～38 parts.
Make described disinfection sanitizer effective ingredient raw material composition and parts by weight be:
Fructus nephelii topengii 34～42 parts, Herba tiarellae polyphyllae 34～42 parts, Herba Ajugae Lupulinae 33～41 parts, Herba Boenninghauseniae Albiflorae 32～40 parts, poinsettia
32～40 parts, Folium Phyllanthi 32～40 parts, Bulbus Allii 31～39 parts, Radix Lespedezae Chinensis 30～38 parts, Flos Caryophylli 30～38 parts, Xian 29～
37 parts, Bulbus Cardiocrini Cathayani 28～36 parts, Radix embeliae laetae 28～36 parts, thunderclap pasture and water 28～36 parts and Radix panici repentics 26～34 parts.
Make described disinfection sanitizer effective ingredient raw material composition and parts by weight be:
Fructus nephelii topengii 38 parts, Herba tiarellae polyphyllae 38 parts, Herba Ajugae Lupulinae 37 parts, Herba Boenninghauseniae Albiflorae 36 parts, poinsettia 36 parts, Folium Phyllanthi 36 parts,
35 parts of Bulbus Allii, Radix Lespedezae Chinensis 34 parts, Flos Caryophylli 34 parts, Xian 33 parts, Bulbus Cardiocrini Cathayani 32 parts, Radix embeliae laetae 32 parts, 32 parts of thunderclap pasture and water and
Radix panici repentics 30 parts.
A kind of preparation method of operating room disinfection sanitizer, it is characterised in that: comprise the following steps that:
(1) Fructus nephelii topengii, Herba Ajugae Lupulinae, Folium Phyllanthi, Bulbus Allii, Flos Caryophylli and Radix panici repentics are cleaned, put into container, add 8
～10 distilled water of times amount, after soaking 5～6 hours, boil 3～4 hours, extract；Again add 6～8 times amount distilled water, boil
2～3 hours, extract；Finally, add 4～6 times amount distilled water, heated and boiled 1～2 hours, extract；Merge three extracting solution, mistake
Filter, obtains filtrate, and heating is concentrated into pasty state, puts into after 70 DEG C of baking oven is dried and cools down, grinds to form fine powder, standby；
(2) Herba tiarellae polyphyllae and thunderclap pasture and water are cleaned, immerse the alcohol solution dipping 1～2 that 3 times amount volumetric concentrations are 60% little
Time, heating extraction 3 hours, to reclaim ethanol, filter, obtain filtrate, concentration is that at 65 DEG C, relative density is the thick paste of 1.12～1.16,
Put into after 70 DEG C of baking oven is dried and cool down, grind to form fine powder, standby；
(3) Herba Boenninghauseniae Albiflorae is put into container, carry out pulverization process, grind into powder, obtain the fine powder of 180 mesh, standby；
(4) poinsettia is dried in the sun, put in pot, slow fire parch 15 minutes, dry in the air cool, grind into powder, obtained 160 mesh
Fine powder, standby；
(5) Radix Lespedezae Chinensis, Xian, Bulbus Cardiocrini Cathayani and Radix embeliae laetae are cleaned, chopping, put into container, twist juice, filter impurity,
Stay juice, standby；
(6) fine powder obtained by above-mentioned steps (1)～(4) is mixed, put into and super micron mill is ground into 0.1～10 μm
The mixed powder that the micron particles of volume average particle size and particle diameter form less than the nano-scale particle of 0.1 μm volume average particle size
Material, the powder rate that obtains of described mixed powder is at least 96%；
(7) mixed powder obtained by above-mentioned steps (6) will add the quality 4 relative to described mixed powder～6 times
The ethanol that determining alcohol is 70%～80%, stirring and dissolving obtain ethanol solution, by ethanol solution 10 DEG C～the condition of 15 DEG C
Lower standing 12～24 hours, use percolation with the speed slowly percolation of per minute 1～2ml, collect percolate, concentrate and do
Dry, and pulverizing 30～60 minutes in super micron mill are put at this, it is thus achieved that the micron particles of 0.1～10 μm volume average particle size
With particle diameter less than 0.1 μm volume average particle size nano-scale particle composition mixed powder, described mixed powder powder rate extremely
It is 96% less；
(8) mixed powder obtained by above-mentioned steps (7) will add the juice obtained by step (5), and add relatively
In mixed powder quality 8～the deionized water of 10 times, after stirring and dissolving is uniform, heated and boiled 2 hours, stand 1 hour, extracted
Filter, obtains filtrate, filtrate fill is sealed up for safekeeping, obtain described operating room disinfection sanitizer.
The property of medicine of Chinese medicine used by the present invention is as follows:
Fructus nephelii topengii: sweet in the mouth, acid, warm in nature；Return spleen, stomach warp.Cold expelling dysentery relieving, heat-clearing and toxic substances removing.Cure mainly dysentery, trusted subordinate's cold type of pain, skin infection.
" Luchuan book on Chinese herbal medicine " carries: " anti-inflammation and sterilization.Control stomatitis, dysentery, wash ulcer.”
Herba tiarellae polyphyllae: bitter in the mouth, cold in nature, nontoxic；Return lung meridian.Heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain.Cure mainly furuncle, unknown
Swell and ache, cough, asthma, hepatitis, traumatic injury." figure will planted by Sichuan WuLong's medicine " carries: " control deafness, asthma.”
Herba Ajugae Lupulinae: bitter in the mouth, pungent, cold in nature；Return lung, stomach, Liver Channel.Heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.Cure mainly affection due to external wind and heat,
Unconsciousness due to high fever, tells nosebleed, and face is completed mouth and drunk, hypertension, lung-heat cough with asthma, lung abscess, and dysentery is suffered from abdominal pain, hepatitis, lithangiuria, acute appendicitis, conjunctival congestion
Swell and ache, laryngopharynx swelling and pain, syphilis, furuncle toxic swelling, traumatic injury congestive edema, traumatic hemorrhage, venom." Chinese herbal medicine is commonly used in Tibet " carries: " clear
Thermal detoxification, relieving stranguria by diuresis, removing heat from blood blood pressure lowering.Controlling affection due to external wind and heat, hypertension, pharyngolaryngitis, bronchitis, lithangiuria, carbuncle sore swells
Poison.”
Herba Boenninghauseniae Albiflorae: acrid in the mouth, hardship, cool in nature；Return lung, liver, spleen channel.Induce sweat preventing the attack (or recurrence) of malaria, promoting blood circulation and detoxication.Cure mainly flu, pharyngolaryngitis, liver
Scorching, spitting of blood, epistaxis, lumbago, traumatic injury, ecchymoma." choosing of Yunnan Chinese herbal medicine " carries: " clearing away heat and cooling blood, relaxing muscles and tendons to promote blood circulation, antiinflammatory.
Cure cold, pharyngolaryngitis, hepatitis, spitting of blood, epistaxis, lumbago, traumatic injury, ecchymoma.”
Poinsettia: bitter in the mouth, cool in nature.Heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Cure mainly upper respiratory tract infection, oral ulcer, pneumonia, breast
Adenitis, enteritis, bacillary dysentery, urinary tract infection, furuncle carbuncle, eczema, traumatic injury, heat clearing away." Guangxi practicality Chinese herbal medicine newly selects " carries:
" anti-inflammation.Control acute upper respiratory tract scorching, pneumonia, tonsillitis, oral ulcer, mastitis, chronic pelvic inflammatory disease, dysentery, abdomen
Rush down, venom.”
Folium Phyllanthi: sweet in the mouth, micro-hardship, cool in nature；GUIXIN, liver, large intestine channel.Heat-clearing and toxic substances removing, inducing diuresis and reducing edema.Cure mainly aphtha, furuncle,
Eczema, dermatitis, edema, hypertension, venom, traumatic injury." Luchuan book on Chinese herbal medicine " carries: " sterilization removing the necrotic tissue.Control erosion of mucous membrane of the oral cavity, eczema of scrotum
And infantile malnutrition, furuncle, leakage, hemorrhoid.”
Bulbus Allii: acrid in the mouth, sweet, warm in nature；Enter spleen, stomach, lung meridian.Removing toxic substances parasite killing, reducing swelling and alleviating pain, antidiarrheal dysentery relieving, control lung, anthelmintic,
Warming the spleen warming the stomach.Cure mainly swollen ulcer drug, white bald tinea skin ulcer, dysentery, have loose bowels, pulmonary tuberculosis pertussis, ascarid pinworm, eating accumulation, coldness and pain in the epigastrium,
Edema distension." occupying diet spectrum with breath " carries: " survivor is hot, the sweet temperature of ripe person, eliminating cold-damp, wards off YIN pathogen, in lower hot air heating, and grain-meat digesting,
Broken stagnant blood, attacks cold long-pending.Control sudden attack of spouting diarrhea stomachache, clearance lattice constipation, ward off dirty removing toxic substances, the painful abdominal mass that disappears parasite killing.Outer moxibustion carbuncle, row water only nosebleed.”
Radix Lespedezae Chinensis: bitter in the mouth, cool in nature；Return liver, gallbladder, large intestine channel.Heat-clearing and toxic substances removing, depressed lung-energy dispersing, preventing the attack (or recurrence) of malaria, expelling wind and removing dampness.
Cure mainly infantile hyperpyrexia, heatstroke sun stroke, asthma, dysentery, acute mastitis, swollen ulcer drug, malaria, pyretic stranguria, tinea pedis, rheumatic arthralgia." the Zhejiang people
Between conventional medical herbs " carry: " clearing away heat to cure dysentery, wind-expelling pain-stopping, preventing the attack (or recurrence) of malaria.”
Flos Caryophylli: sweet in the mouth, pungent, the hottest；Enter stomach, kidney two warp.Warming the stomach, the kidney warming.Cure mainly cold syndrome of the stomach pain with distension, singultus, vomit and diarrhoea, arthralgia pain,
Colic, halitosis, toothache." Japan hanako materia medica " carries: " controls implication, regurgitation, treats kidney qi, sensation of gas rushing, pain over the perineum, tonifying YANG, warm waist knee joint, kill
Wine Chinese medicine " Flos Caryophylli " actually Myrtaceae Flos Caryophylli poison, disappear mass beside the umbilicus, except consumptive disease with cold nature.”
Xian: bitter in the mouth, cold in nature；Enter liver,spleen,kidney warp.Wind-damp dispelling, relieving rigidity of muscles and joints, blood pressure lowering.Curing mainly quadriplegia, muscles and bones is ached
Bitterly, weakness of the waist and knees, malaria, acute hepatitis, hypertension, furuncle swelling toxin, traumatic hemorrhage.Guangzhou army " conventional Chinese herbal medicine handbook "
Carry: " blood pressure lowering of calming the nerves, wind-expelling pain-stopping.Control neurasthenia, insomnia, hypertension, rheumatic arthralgia, snake bite and insect sting.”
Bulbus Cardiocrini Cathayani: bitter in the mouth, micro-sweet, cool in nature.Clearing away lung-heat to relieve cough, removing toxic substances and promoting subsidence of swelling.Cure mainly flu, cough due to lung-heat, spit blood, nasal sinusitis,
Ceruminal impaction, acute mastitis, innominate toxic swelling." Guizhou folk medicine " carries: " detumescence, detoxification.”
Radix embeliae laetae: sour in the mouth, puckery, cool in nature.Heat-clearing and toxic substances removing, dissipating blood stasis stops blooding.Cure mainly laryngopharynx swelling and pain, gingiva bleeding gingival hemorrhage, diarrhea due to hypofunction of the spleen,
Traumatic injury stasis of blood pain, hemorrhoid." Luchuan book on Chinese herbal medicine " carries: " antiinflammatory, sterilization.Control stomatitis, laryngitis, gingivitis, furuncle ulcer etc..And solve big
Tea poison of drug, wood eat poison, Fructus Crotonis poison.”
Thunderclap pasture and water: sweet in the mouth, hardship, cold in nature.Qi-restoratives dehumidifies, relaxing muscles and tendons and activating QI and blood in the collateral.Curing mainly deficiency-heat not move back, oedema due to nephritis, rheumatic is closed
Joint pain, eczema." choosing of Simao, Yunnan Chinese herbal medicine " carries: " relaxing muscles and tendons and activating QI and blood in the collateral, wind-damp dispelling, diuresis, treating rheumatic arthritis, waist knee joint is wet
Numbness, oedema due to nephritis.”
Radix panici repentics: sweet in the mouth, hardship, property is put down.Heat clearing away suppressing the hyperactive liver, eliminating damp, detoxifying, blood circulation promoting and blood stasis dispelling.Cure mainly hypertension, epistaxis is wet
Under the torrid zone, stranguria with turbid discharge, sinusitis, parotitis, icterohepatitis, venom, traumatic injury.
The present invention compared with prior art, has the advantages that
1, disinfection sanitizer of the present invention has wind-expelling pain-stopping, heat-clearing and toxic substances removing, effect of antiphlogistic antibacterial, and effect significantly, makes
By safety, nonirritant, with low cost, can effectively kill virus, antibacterial, fungus and pathogen, it is to avoid pathogenic bacteria is in atmosphere
Propagation.
2, disinfection sanitizer stability of the present invention is strong, non-corrosiveness, soluble in water, without any toxicity, reducing performs the operation feels
The generation of dye, improves the safety of operation, is highly suitable for large-scale promotion in the operating room of hospital and uses.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material of disinfection sanitizer effective ingredient of the present invention forms and weight is:
Fructus nephelii topengii 46g, Herba tiarellae polyphyllae 46g, Herba Ajugae Lupulinae 45g, Herba Boenninghauseniae Albiflorae 44g, poinsettia 44g, Folium Phyllanthi 44g, Bulbus Allii
43g, Radix Lespedezae Chinensis 42g, Flos Caryophylli 42g, Xian 41g, Bulbus Cardiocrini Cathayani 40g, Radix embeliae laetae 40g, thunderclap pasture and water 40g and Radix panici repentics 38g.
The preparation method of a kind of operating room disinfection sanitizer, comprises the following steps that:
(1) Fructus nephelii topengii, Herba Ajugae Lupulinae, Folium Phyllanthi, Bulbus Allii, Flos Caryophylli and Radix panici repentics are cleaned, put into container, add 8
～10 distilled water of times amount, after soaking 5～6 hours, boil 3～4 hours, extract；Again add 6～8 times amount distilled water, boil
2～3 hours, extract；Finally, add 4～6 times amount distilled water, heated and boiled 1～2 hours, extract；Merge three extracting solution, mistake
Filter, obtains filtrate, and heating is concentrated into pasty state, puts into after 70 DEG C of baking oven is dried and cools down, grinds to form fine powder, standby；
(2) Herba tiarellae polyphyllae and thunderclap pasture and water are cleaned, immerse the alcohol solution dipping 1～2 that 3 times amount volumetric concentrations are 60% little
Time, heating extraction 3 hours, to reclaim ethanol, filter, obtain filtrate, concentration is that at 65 DEG C, relative density is the thick paste of 1.12～1.16,
Put into after 70 DEG C of baking oven is dried and cool down, grind to form fine powder, standby；
(3) Herba Boenninghauseniae Albiflorae is put into container, carry out pulverization process, grind into powder, obtain the fine powder of 180 mesh, standby；
(4) poinsettia is dried in the sun, put in pot, slow fire parch 15 minutes, dry in the air cool, grind into powder, obtained 160 mesh
Fine powder, standby；
(5) Radix Lespedezae Chinensis, Xian, Bulbus Cardiocrini Cathayani and Radix embeliae laetae are cleaned, chopping, put into container, twist juice, filter impurity,
Stay juice, standby；
(6) fine powder obtained by above-mentioned steps (1)～(4) is mixed, put into and super micron mill is ground into 0.1～10 μm
The mixed powder that the micron particles of volume average particle size and particle diameter form less than the nano-scale particle of 0.1 μm volume average particle size
Material, the powder rate that obtains of described mixed powder is at least 96%；
(7) mixed powder obtained by above-mentioned steps (6) will add the quality 4 relative to described mixed powder～6 times
The ethanol that determining alcohol is 70%～80%, stirring and dissolving obtain ethanol solution, by ethanol solution 10 DEG C～the condition of 15 DEG C
Lower standing 12～24 hours, use percolation with the speed slowly percolation of per minute 1～2ml, collect percolate, concentrate and do
Dry, and pulverizing 30～60 minutes in super micron mill are put at this, it is thus achieved that the micron particles of 0.1～10 μm volume average particle size
With particle diameter less than 0.1 μm volume average particle size receive Six-Meter Class granule composition mixed powder, described mixed powder powder rate extremely
It is 96% less；
(8) mixed powder obtained by above-mentioned steps (7) will add the juice obtained by step (5), and add relatively
In mixed powder quality 8～the deionized water of 10 times, after stirring and dissolving is uniform, heated and boiled 2 hours, stand 1 hour, extracted
Filter, obtains filtrate, filtrate fill is sealed up for safekeeping, obtain described operating room disinfection sanitizer.
Embodiment 2
The raw material of disinfection sanitizer effective ingredient of the present invention forms and weight is:
Fructus nephelii topengii 42g, Herba tiarellae polyphyllae 42g, Herba Ajugae Lupulinae 41g, Herba Boenninghauseniae Albiflorae 40g, poinsettia 40g, Folium Phyllanthi 40g, Bulbus Allii
39g, Radix Lespedezae Chinensis 38g, Flos Caryophylli 38g, Xian 37g, Bulbus Cardiocrini Cathayani 36g, Radix embeliae laetae 36g, thunderclap pasture and water 36g and Radix panici repentics 34g.
The disinfection sanitizer preparation method processing step of the present embodiment is same as in Example 1.
Embodiment 3
The raw material of disinfection sanitizer effective ingredient of the present invention forms and weight is:
Fructus nephelii topengii 38g, Herba tiarellae polyphyllae 38g, Herba Ajugae Lupulinae 37g, Herba Boenninghauseniae Albiflorae 36g, poinsettia 36g, Folium Phyllanthi 36g, Bulbus Allii
35g, Radix Lespedezae Chinensis 34g, Flos Caryophylli 34g, Xian 33g, Bulbus Cardiocrini Cathayani 32g, Radix embeliae laetae 32g, thunderclap pasture and water 32g and Radix panici repentics 30g.
The disinfection sanitizer preparation method processing step of the present embodiment is same as in Example 1.
Embodiment 4
The raw material of disinfection sanitizer effective ingredient of the present invention forms and weight is:
Fructus nephelii topengii 34g, Herba tiarellae polyphyllae 34g, Herba Ajugae Lupulinae 33g, Herba Boenninghauseniae Albiflorae 32g, poinsettia 32g, Folium Phyllanthi 32g, Bulbus Allii
31g, Radix Lespedezae Chinensis 30g, Flos Caryophylli 30g, Xian 29g, Bulbus Cardiocrini Cathayani 28g, Radix embeliae laetae 28g, thunderclap pasture and water 28g and Radix panici repentics 26g.
The disinfection sanitizer preparation method processing step of the present embodiment is same as in Example 1.
Embodiment 5
The raw material of disinfection sanitizer effective ingredient of the present invention forms and weight is:
Fructus nephelii topengii 30g, Herba tiarellae polyphyllae 30g, Herba Ajugae Lupulinae 29g, Herba Boenninghauseniae Albiflorae 28g, poinsettia 28g, Folium Phyllanthi 28g, Bulbus Allii
27g, Radix Lespedezae Chinensis 26g, Flos Caryophylli 26g, Xian 25g, Bulbus Cardiocrini Cathayani 24g, Radix embeliae laetae 24g, thunderclap pasture and water 24g and Radix panici repentics 22g.
The disinfection sanitizer preparation method processing step of the present embodiment is same as in Example 1.
Experimental section
Below the selection present invention is tested accordingly, prove effect of the present invention further.
One, soluble test
1, take disinfection sanitizer 10ml of the present invention and put in container, be subsequently adding distilled water, after stirring, filter.
2, after having filtered, filter paper is observed, without obvious residue on filter paper.
3, conclusion: disinfection sanitizer of the present invention is highly soluble in water, uses rear noresidue impurity to occur.
Two, toxicity test
1, acute oral test: choose the healthy Kunming kind one-level mice 30 of body weight 18～20g, male and female half and half, incite somebody to action
Disinfection sanitizer per os gastric infusion of the present invention, is administered and observes 10 days, record the various performance of mice and death condition every day, calculates
LD. it is worth.
2, cumulative toxicity test: choose the healthy Kunming kind one-level rat 30 of body weight 160～180g, male and female half and half, incite somebody to action
Disinfection sanitizer per os gastric infusion of the present invention, the LD. value that dosage draws according to acute oral test, the 1st～4 day, often
Secondary administration 0.1LD., is incremented by 1.5 multiple doses, is administered 20 days, and every four hours weigh once for later every four hours, calculates accumulation system
Number.
3, there is not death, solves it accordingly in result: no abnormality seen reaction after acute oral test mice perfusion
After cuing open, tissue or internal organs show no obvious abnormalities change；After cumulative toxicity test is administered 15 days, mice all sends out male and female without death condition
Raw, mice cumulative coefficient 5, for weak cumulative toxicity.
Three, stability test
Take disinfection sanitizer 50ml of the present invention, after placing 90 days under the conditions of 37 DEG C, for staphylococcus aureus is entered
No significant difference is compared before row sterilization, its killing effect and storage.
Four, bacteriostatic test
Below disinfection sanitizer of the present invention is carried out bacteriostatic experiment:
1, lab space selects: select the operating room that three spatial volume are equal as experimental subject.Operating room door and window is equal
Sealing tight, ventilation condition is good, indoor temperature 21～27 DEG C, humidity 60%～80%；Operating room size, surgical staff quantity
And the aspect no significant difference such as surgery duration, there is comparability (P ＞ 0.05).
2, experimental implementation: spray disinfection sanitizer of the present invention 100 milliliters the most equably.12 after spraying are little
Time, within 24 hours, 48 hours, sample by plate sedimentation, if 3 sampled points, 1 diagonal takes 3 points, i.e. in the middle of 1 point, two
End respectively takes 1 point at wall 1m, and is repeated 10 times.After sampling, culture medium is put cultivation 48h in 35 DEG C of incubators, in highlight
Observe bacterial clump quantity in culture medium.
Calculate bacterial number, microbe contents in air (cfu/m3)=every ware average colony number × 50000/ plate as follows
Open-assembly time × plate area.All antibacterials are all identified by " whole nation Clinical Laboratory rule of operation ".
3, experimental technique: bacteriostatic test takes bacterium suspension 1 milliliter and adds in 90mm sterile petri dish, pours 45 DEG C of culture medium into
20ml, rotates culture dish and makes culture medium fully mix with cell, stand condensation.Take aseptic filter paper sheet 4 and be stacked in the suitable of flat board
Preferably position, takes 50 μ l sterilizing agent solutions immediately and drips on filter paper, and every flat board is put at 4 with one-tenth square.Flat board is put
Cultivate in 35 DEG C of incubators, measure an antibacterial circle diameter every 24h.
4, experimental result: disinfection sanitizer of the present invention after spraying 12 hours, 24 hours, 48 hours, bacterial number
(cfu/m3) it is respectively 98,132,168, meets the requirement (≤200) for bacterial number in Clinical Laboratory.
5, effect standard: according to " hospital disinfection sanitary standard " and the regulation of " GB15982-1995 ", in operating room air
Bacterial population≤200cfu/m3, and do not detect staphylococcus aureus.
6, laboratory report: collection result inputs PC, and application SPSS10.0 software kit is added up, before result is for sterilization
10min bacterial population (cfu/m3) is 817, and it is 75 that sterilization terminates bacterial population (cfu/m3) when rear 30min there is no people's activity, after activity
Bacterial population (cfu/m3) is 165.And all do not detect staphylococcus aureus with after activity after sterilization, meet relevant rule
Fixed.
7, experiment conclusion: the average bacteriostasis rate of staphylococcus aureus is all met or exceeded and deposits by disinfection sanitizer of the present invention
Put the average bacteriostasis rate of front respective action time.Conclusion disinfection sanitizer of the present invention has stronger bacteriostasis, stable performance.
The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention makees other form, appoints
What those skilled in the art changed possibly also with the technology contents of the disclosure above or be modified as equivalent variations etc.
Effect embodiment.But every without departing from technical solution of the present invention content, any repaiied according to do in the application range of the present invention
Change, equivalent and improvement etc., should be included within the scope of the present invention.
Claims (5)
1. an operating room disinfection sanitizer, it is characterised in that: make the raw material composition of described disinfection sanitizer effective ingredient
And parts by weight are:
Fructus nephelii topengii 26～50 parts, Herba tiarellae polyphyllae 26～50 parts, Herba Ajugae Lupulinae 25～49 parts, Herba Boenninghauseniae Albiflorae 24～48 parts, poinsettia 24～
48 parts, Folium Phyllanthi 24～48 parts, Bulbus Allii 23～47 parts, Radix Lespedezae Chinensis 22～46 parts, Flos Caryophylli 22～46 parts, Xian 21～45
Part, Bulbus Cardiocrini Cathayani 20～44 parts, Radix embeliae laetae 20～44 parts, thunderclap pasture and water 20～44 parts and Radix panici repentics 19～42 parts.
A kind of operating room disinfection sanitizer the most according to claim 1, it is characterised in that: make described disinfection sanitizer
The raw material of effective ingredient forms and parts by weight are:
Fructus nephelii topengii 30～46 parts, Herba tiarellae polyphyllae 30～46 parts, Herba Ajugae Lupulinae 29～45 parts, Herba Boenninghauseniae Albiflorae 28～44 parts, poinsettia 28～
44 parts, Folium Phyllanthi 28～44 parts, Bulbus Allii 27～43 parts, Radix Lespedezae Chinensis 26～42 parts, Flos Caryophylli 26～42 parts, Xian 25～41
Part, Bulbus Cardiocrini Cathayani 24～40 parts, Radix embeliae laetae 24～40 parts, thunderclap pasture and water 24～40 parts and Radix panici repentics 22～38 parts.
A kind of operating room disinfection sanitizer the most according to claim 1, it is characterised in that: make described disinfection sanitizer
The raw material of effective ingredient forms and parts by weight are:
Fructus nephelii topengii 34～42 parts, Herba tiarellae polyphyllae 34～42 parts, Herba Ajugae Lupulinae 33～41 parts, Herba Boenninghauseniae Albiflorae 32～40 parts, poinsettia 32～
40 parts, Folium Phyllanthi 32～40 parts, Bulbus Allii 31～39 parts, Radix Lespedezae Chinensis 30～38 parts, Flos Caryophylli 30～38 parts, Xian 29～37
Part, Bulbus Cardiocrini Cathayani 28～36 parts, Radix embeliae laetae 28～36 parts, thunderclap pasture and water 28～36 parts and Radix panici repentics 26～34 parts.
A kind of operating room disinfection sanitizer the most according to claim 1, it is characterised in that: make described disinfection sanitizer
The raw material of effective ingredient forms and parts by weight are:
Fructus nephelii topengii 38 parts, Herba tiarellae polyphyllae 38 parts, Herba Ajugae Lupulinae 37 parts, Herba Boenninghauseniae Albiflorae 36 parts, poinsettia 36 parts, Folium Phyllanthi 36 parts, Bulbus Allii
35 parts, Radix Lespedezae Chinensis 34 parts, Flos Caryophylli 34 parts, Xian 33 parts, Bulbus Cardiocrini Cathayani 32 parts, Radix embeliae laetae 32 parts, 32 parts of thunderclap pasture and water and floor file
Radix Panici miliacei 30 parts.
5. a preparation method for operating room disinfection sanitizer as described in any one of Claims 1 to 4, it is special
Levy and be: comprise the following steps that:
(1) Fructus nephelii topengii, Herba Ajugae Lupulinae, Folium Phyllanthi, Bulbus Allii, Flos Caryophylli and Radix panici repentics are cleaned, put into container, add 8～10
The distilled water of times amount, after soaking 5～6 hours, boils 3～4 hours, extracts；Again add 6～8 times amount distilled water, boil 2～3
Hour, extract；Finally, add 4～6 times amount distilled water, heated and boiled 1～2 hours, extract；Merge three extracting solution, filter,
Obtaining filtrate, heating is concentrated into pasty state, puts into after 70 DEG C of baking oven is dried and cools down, grinds to form fine powder, standby；
(2) Herba tiarellae polyphyllae and thunderclap pasture and water are cleaned, immerse alcohol solution dipping 1～2 hours that 3 times amount volumetric concentrations are 60%, heating
Extracting 3 hours, reclaim ethanol, filter, obtain filtrate, concentration is that at 65 DEG C, relative density is the thick paste of 1.12～1.16, puts into baking
70 DEG C of case cools down after drying, and grinds to form fine powder, standby；
(3) Herba Boenninghauseniae Albiflorae is put into container, carry out pulverization process, grind into powder, obtain the fine powder of 180 mesh, standby；
(4) poinsettia is dried in the sun, put in pot, slow fire parch 15 minutes, dry in the air cool, grind into powder, obtained 160 purposes thin
Powder, standby；
(5) Radix Lespedezae Chinensis, Xian, Bulbus Cardiocrini Cathayani and Radix embeliae laetae are cleaned, chopping, put into container, twist juice, filter impurity, stay juice
Liquid, standby；
(6) fine powder obtained by above-mentioned steps (1)～(4) is mixed, put into and super micron mill is ground into 0.1～10 μm volumes
The mixed powder that the micron particles of mean diameter and particle diameter form less than the nano-scale particle of 0.1 μm volume average particle size, institute
The powder rate that obtains stating mixed powder is at least 96%；
(7) mixed powder obtained by above-mentioned steps (6) will add the quality 4 relative to described mixed powder～the alcohol of 6 times
Concentration is the ethanol of 70%～80%, and stirring and dissolving obtains ethanol solution, is stood by ethanol solution under conditions of 10 DEG C～15 DEG C
12～24 hours, use percolation with the speed slowly percolation of per minute 1～2ml, collect percolate, be concentrated and dried, and
This puts in super micron mill and pulverizes 30～60 minutes, it is thus achieved that the micron particles of 0.1～10 μm volume average particle size and particle diameter
The mixed powder formed less than the nano-scale particle of 0.1 μm volume average particle size, the powder rate that obtains of described mixed powder is at least
96%；
(8) mixed powder obtained by above-mentioned steps (7) will add the juice obtained by step (5), and add relative to mixed
Close powder quality 8～the deionized water of 10 times, after stirring and dissolving is uniform, heated and boiled 2
Hour, stand 1 hour, extract and filter, obtain filtrate, filtrate fill is sealed up for safekeeping, obtain described operating room sterilizing
Agent.
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| CN106234472A (en) * | 2016-07-29 | 2016-12-21 | 王雪雪 | A kind of operating room disinfection sanitizer and preparation method |
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Application publication date: 20161207 |