CN105853263A - Traditional Chinese medicinal mosquito repelling liquid and preparation method thereof - Google Patents
Traditional Chinese medicinal mosquito repelling liquid and preparation method thereof Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention provides a traditional Chinese medicinal mosquito repelling liquid. The traditional Chinese medicinal mosquito repelling liquid comprises, by weight, 10-20 parts of Artemisia argyi, 10-20 parts of Spina Gleditsiae, 10-20 parts of dahurian angelica root, 10-20 parts of Syzygium aromaticum, 10-20 parts of mint, 10-20 parts of perilla frutescens, 10-20 parts of Acorus calamus Linn, 10-20 parts of Hedyotis diffusa, 10-20 parts of Amur Corktree Bark, 10-20 parts of sophora flavescens, 10-20 parts of bletilla striata, 10-20 parts of Divaricate Saposhnikovia Root, 10-20 parts of Litsea cubeba, 10-20 parts of Lithospermum erythrorhizon, 10-20 parts of Herba Moslae and 10-20 parts of Herba Speranskiae Tuberculatae. The mosquito repelling liquid has the advantages of mosquito biting prevention, no toxic or side effects, no damages to skins, easy cleaning, no uncomfortable greasy feeling after beinig sprayed or smeared on skins, no influences on sweat and sebum secretion, long mosquito prevention validity period, and good market prospect.
Description
Technical field
The present invention relates to containing the pharmaceutical product deriving from plant, animal or mineral component, particularly to a kind of Chinese medicine mosquito-driving liquid and preparation method thereof.
Background technology
Summer, mosquito wreaked havoc, and estimation is the problem that everyone is worried.Along with electric mosquito-repellent incense, the application of mosquito-driving liquid, certain effect is striking.But electric mosquito repellent liquid has certain toxicity, everybody it should be appreciated that these invisible chemical gas that also can't smell that can not touch, is not distributing toxin, is accumulating over a long period and encroach on our health.Along with the Continued of temperature, mosquito starts to haunt the most gradually, and many health preserving intelligents start to shine the self-control anophelifuge equipment of oneself in online microblogging, wechat, invite many online friends to imitate.But, also someone queries these and equips equipped with the anophelifuge of Chinese medicine and really have repelling effect, even worries medical herbs therein whether toxic side effect.
Chinese herbal medicine Anti-mosquito disinsectization is not any strange thing, in the history of the existing more than one thousand years of China, mainly holds anophelifuge medical material with sachet, body-worn or be placed in room.The Chinese herbal medicine such as the Rhizoma Acori Graminei that often comprises in the sachet of general anophelifuge, Folium Artemisiae Argyi, the Radix Angelicae Dahuricae, Herba Eupatorii, Herba Menthae, Herba Pogostemonis, these broadly fall into fragrance medicine, containing volatile oil, can volatilize the taste that mosquito does not likes under natural environment, so repelling effect can be reached.
Effect that some Chinese medicines have " fragrance is warded off turbid " is also had in general authentic anophelifuge sachet.Such as Rhizoma Acori Graminei, the Radix Angelicae Dahuricae etc. can suppress fungus effectively, have suppression virus and bactericidal action, and Herba Moslae etc. helps relieves summer heat and warming the stomach, help the anorexia that prevention summer fever causes for child.Additionally some medical herbs also has calm soporific function.
The medicine of the pungent fragrant class in some anophelifuge sachets is more, and for anemia of pregnant woman, especially conceived first trimester is not suitable for long-term body-worn, otherwise may cause the adverse consequencess such as habitual abortion.Anophelifuge medical herbs is many containing aromatic substance with volatile oil, these are all that the people of allergic constitution should use with caution, body constitution difference according to individual, likely cause skin and mucous membrane hypersusceptibility reaction, so the crowd of allergic constitution is also not suitable for next to the skin wearing, hang over evening in the head of a bed or mosquito net, it is to avoid directly contact skin causes the situation of allergy as far as possible.It is pointed out that can be the most mosquito-proof by the physical isolation mode such as mosquito net screen window, only the most limited by sachet expelling mosquito effect.
Chinese medicine anophelifuge has certain effect, but the abnormal smells from the patient of Chinese medicine sachet the most just reduces, and often changes guarantee repelling effect.So the Chinese medicine mosquito-driving liquid of concentration extraction, have and prevent mosquito bite, and have no side effect, not injured skin, easy cleaning, spray or put on the skin the greasy feeling being put on skin without uncomfortable, the most do not hinder the secretion of perspiration and sebum, mosquito-proof effect duration is long.There is good market prospect.
Summary of the invention
The technical problem to be solved is, finds one and has and prevent mosquito bite, and has no side effect, not injured skin, easy cleaning, spray or put on the skin the greasy feeling being put on skin without uncomfortable, the most do not hinder the secretion of perspiration and sebum, the product of mosquito-proof effect duration length.But chemistry mosquito-driving liquid strong toxicity, big to human injury, Chinese medicine repelling effect can not be lasting.
For solving these technical barriers, the invention provides a kind of Chinese medicine mosquito-driving liquid, its described Chinese medicine mosquito-driving liquid can include the crude drug of following parts by weight: Folium Artemisiae Argyi 10～20 parts, Spina Gleditsiae 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, Flos Caryophylli 10～20 parts, Herba Menthae 10～20 parts, Folium Perillae 10～20 parts, Rhizoma Acori Graminei 10～20 parts, Herba Hedyotidis Diffusae 10～20 parts, Cortex Phellodendri 10～20 parts, Radix Sophorae Flavescentis 10～20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20 parts, Radix Saposhnikoviae 10～20 parts, Fructus Litseae pungentis 10～20 parts, Radix Arnebiae (Radix Lithospermi) 10～20 parts, Herba Moslae 10～20 parts, Herba speranskiae tuberculatae 10～20 parts.
Described Chinese medicine mosquito-driving liquid, its described Chinese medicine mosquito-driving liquid can also include the crude drug of following parts by weight: Folium Artemisiae Argyi 10～15 parts, Spina Gleditsiae 10～15 parts, the Radix Angelicae Dahuricae 10～15 parts, Flos Caryophylli 10～15 parts, Herba Menthae 10～15 parts, Folium Perillae 10～15 parts, Rhizoma Acori Graminei 10～15 parts, Herba Hedyotidis Diffusae 10～15 parts, Cortex Phellodendri 10～20 parts, Radix Sophorae Flavescentis 10～20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20 parts, Radix Saposhnikoviae 10～20 parts, Fructus Litseae pungentis 10～20 parts, Radix Arnebiae (Radix Lithospermi) 10～20 parts, Herba Moslae 10～20 parts, Herba speranskiae tuberculatae 10～20 parts.
Described Chinese medicine mosquito-driving liquid, its described Chinese medicine mosquito-driving liquid can also include the crude drug of following parts by weight: Folium Artemisiae Argyi 10～20 parts, Spina Gleditsiae 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, Flos Caryophylli 10～20 parts, Herba Menthae 10～20 parts, Folium Perillae 10～20 parts, Rhizoma Acori Graminei 10～20 parts, Herba Hedyotidis Diffusae 10～20 parts, Cortex Phellodendri 10～15 parts, Radix Sophorae Flavescentis 10～15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～15 parts, Radix Saposhnikoviae 10～15 parts, Fructus Litseae pungentis 10～15 parts, Radix Arnebiae (Radix Lithospermi) 10～15 parts, Herba Moslae 10～15 parts, Herba speranskiae tuberculatae 10～15 parts.
For solving above-mentioned technical problem, the present invention also provides for the preparation method of a kind of Chinese medicine mosquito-driving liquid, and the preparation method of its described Chinese medicine mosquito-driving liquid comprises the following steps:
A. take Flos Caryophylli, the Radix Angelicae Dahuricae, Herba Menthae, Rhizoma Acori Graminei, Herba Moslae and the Fructus Litseae pungentis way of distillation and be vaporized into crystallization, pulverize dusting cover stand-by, as component 1.
B. the extraction of surplus stock medicinal alcohol is taken, as component 2；
C. by stripped for ethanol medicinal residues soak by water 2 times, concentrated extracting solution is merged, as component 3；
D. by 2-in-1 for component 1 component and be condensed into concentrated solution, it is divided into bottle packaging.
In described step a, first crude drug Flos Caryophylli, the Radix Angelicae Dahuricae, Herba Menthae, Rhizoma Acori Graminei, Herba Moslae and Fructus Litseae pungentis steam method can be distilled, obtain crystal, then pulverize, cross 100-120 mesh sieve, standby as component 1.
In described step b, can be shredded by remaining crude drug, be soaked and be placed in lid stainless steel cask, add 70% ethanol, quality is coarse grained 0.8-1 times, stirs, moistening airtight placement more than 1 hour, makes fully to expand；By bottom percolator filter plate gauze bag parcel pave after again the drug sample after moistening expansion is mixed pine do dissipate, then powder is contained with rustless steel spoon, load percolator uniformly, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitably pressurization, medicated powder loads 2/3 eminence that must not exceed percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, is then slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, controlling percolation speed and be generally 1000g medical material outflow per minute 2～3ml, filtrate puts into liquid container, and pours ethanol during emptying into liquid container；Being merged by percolate and stand, stand for standby use, as component 2.
In described step c, can above-mentioned stripped raw material residue be put in 10 times amount water, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, united extraction liquid, 100-120 mesh filters, then the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming, the filtrate of 1.05 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, as component 3.
In described step d, component 2 can be merged with component 3, put in economic benefits and social benefits vacuum concentrator and mix, first concentrating the filtrate to relative density when 80 DEG C is the concentrated solution of 1.32, sets to 0～5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr that cold preservation liquid is added 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml concentrated solution Han 0.1g, add component 1 stir sub-bottle load, the present invention do not contain chemical composition, be difficult to preserve, palpus cold preservation.
For solving above-mentioned technical problem, the present invention also provides for the preparation method of a kind of Chinese medicine mosquito-driving liquid, and the preparation method of its described Chinese medicine mosquito-driving liquid can also be:
A. take Flos Caryophylli, the Radix Angelicae Dahuricae, Herba Menthae, Rhizoma Acori Graminei, Herba Moslae and the Fructus Litseae pungentis way of distillation and be vaporized into crystallization, pulverize dusting cover stand-by, as component 1；
B. by remaining raw material ethanol extraction 2 times, concentrate, as component 2；
C. after component 1, component 2 uniformly being mixed, subpackage.
In described step a, first crude drug Flos Caryophylli, the Radix Angelicae Dahuricae, Herba Menthae, Rhizoma Acori Graminei, Herba Moslae and Fructus Litseae pungentis steam method can be distilled, obtain crystal, then pulverize, cross 100-120 mesh sieve, standby as component 1；In described step b, remaining crude drug can be steeped in 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, united extraction liquid, 100-120 mesh filters, then the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming, the filtrate of 1.25 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, as component 2；In described step c, component 1 can be put in component 2, stir, subpackage, the present invention does not contains chemical composition, is difficult to preserve, must cold preservation..
The anophelifuge of the present invention has and prevents mosquito bite, and has no side effect, not injured skin, easy cleaning, sprays or puts on the skin the greasy feeling being put on skin without uncomfortable, the most do not hinder the secretion of perspiration and sebum, and mosquito-proof effect duration is long.
Detailed description of the invention
Chinese medicine includes mineral drug, animal drugs and plant amedica (Chinese herbal medicine), and wherein plant amedica is then to use most class Chinese medicine.About the research of plant amedica disinsectization performance, domestic main employing extracts deworm, the most also has the substantial amounts of research about plant amedica extract anthelmintic.And relate generally to extract kill parasite of human particularly with regard to Chinese medicine Pericarpium Zanthoxyli, Folium Artemisiae Argyi, Nicotiana tabacum L. Tapeworm canine, and Research Literature is less.Consult part Research Literature and find that Pericarpium Zanthoxyli decoct can resist the insecticides such as trichomonal vaginitis, lethal confused flour beetle adult, honeycomb worm, beet armyworm female adult worm, and Coptotermes formosanus Shtrari., Blatta seu periplaneta, housefly.There is scholar, with Folium Artemisiae Argyi extract, beet armyworm female adult worm has been carried out deterrent effect research, find that the repellent rate effect of beet armyworm be there are differences by extract and different fractions.Folium Artemisiae Argyi extract also has repellent effect to mosquito midge, and the use of Nicotiana tabacum L. anthelmintic is primarily present among folks of china, the most detailed research.Can be seen that from these results of study and thinking, Most scholars uses the method for effective component extracting that Chinese herbal medicine is carried out insect-expelling function research, although gained Effective Component of Chinese Medicine can quickly kill or mosquito repellent, but, the pollutant that a large amount of chemical drugss consumed during extraction and Chinese herbal medicine stay, but bring huge injury to environment for human survival.And, Chinese herbal medicine internal some can the component of comprehensive function anthelmintic can lose during extracting, cause insecticide that single medicine is produced drug resistance effect, and then ineffective.Present invention preparation has antibacterial and synthesis, is similar to the elementary material that " gene chip " combines, compound anthelmintic, and combines as a functional part and play its antibacterial, function for expelling pests in building materials.Compared with existing anthelmintic building materials, cost and carrying capacity of environment will greatly reduce, and lasting effect increases, and insecticide is difficult to develop immunity to drugs.
Radix Angelicae Dahuricae meridian distribution of property and flavor: pungent, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, sensible pain relieving, detumescence and apocenosis, dampness leukorrhagia stopping." Japan hanako materia medica ": control conjunctival congestion bulbar conjunctiva polyp, and tire patching leakage landing, broken stagnated blood, mend fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, evacuation of pus, desolation, scabies, pain relieving granulation promoting, go face defect scar.
Herba Moslae, Latin literary fame；Elsholtzia ciliata(Thunb.) Hyland. Herba Moslae energy relieving the exterior syndrome by diaphoresis, removing dampness for regulating stomach, inducing diuresis to remove edema.Cure mainly: Xia Yue sense cold fluid-retention is cold, has a headache and fever, and aversion to cold is lossless, and the feeling of stuffiness in chest is suffered from abdominal pain, vomiting and diarrhoea, edema, tinea pedis." Amplification on Materia Medica addendum ": cure the wound summer-heat, diuresis." the southern regions of the Yunnan Province book on Chinese herbal medicine ": evil removing of inducing sweat, controls heatstroke headache, diarrhea due to summer-heat intestines and stomach pain, and summer-heat is coughed, diaphoresis, stomach warming, and in.
Pseudobulbus Bletillae (Rhizoma Bletillae) meridian distribution of property and flavor: bitter in the mouth, sweet, puckery, cold in nature, return lung, liver, stomach warp.Having astringing to arrest bleeding, the merit of detumescence and promoting granulation, for all cards of interior external haemorrhage and carbuncle, scald, rhagadia manus et pedis, anal fissure etc..The Pseudobulbus Bletillae (Rhizoma Bletillae) has medical value and Ornamental value widely.It is mainly used in astringing to arrest bleeding, detumescence and promoting granulation.Shennong's Herbal: " main carbuncle, malignant boil, lose cellulitis, the dead flesh of impairment of YIN, pathogen in stomach ".
The leaf of Flos Caryophylli can be used as medicine, bitter in the mouth, cold in nature, have an effect of heat clearing and damp drying, among the people be used for antidiarrheal.The solution that the fresh leaf of Syringa oblata Lindl. is made, carries out extracorporeal bacteria inhibitor test to bacterium flexneri, and effect is stronger；For preventing and treating bacillary dysentery, both economical, it is easy to again promote.Treating acute icterohepatitis with leaf of Syringa oblata Lindl., its short treating period, jaundice is notable.The tablet made with the extractum of leaf of Syringa oblata Lindl.--liver Trane sheet, treats acute icterohepatitis, clinical practice, truly has certain curative effect, and safety, again non-toxic reaction.Bark: heat clearing and damp drying, relieving cough and relieving asthma.Leaf: bitter, cold.Heat clearing away, removing toxic substances, cough-relieving, dysentery relieving.For productive cough of coughing, dysentery, mumps, hepatitis
Herba Hedyotidis Diffusae: sweet, light is cool.Heat-clearing and toxic substances removing, dampness removing eliminating carbuncle, anticancer.For malignant tumor, acute appendicitis, laryngopharynx swelling and pain, jaundice due to damp-heat, dysuria, furuncle toxic swelling, its patent medicine bitter in the mouth of venom, light, cold in nature.Primary efficacy is heat-clearing and toxic substances removing, medicinal powder for relieving pain knot, promoting urination to remove dampness.Outstanding kind treatment all kinds inflammation.In clinical practice, if finding, Herba Hedyotidis Diffusae compatibility is proper, can treat multiple disease.
Herba Menthae is one of China's conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls influenza, the disease such as headache, conjunctival congestion, fever of the body, throat, dental bed swell and ache.External can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc..Usually with Herba Menthae for tea, clear away heart-fire improving eyesight.
Fructus Litseae pungentis, English name: FruitofPungentLitse, FruitofFourflowerLitse, PungentLitse, another name: Fructus Linderae Glaucae, Litsea chenii, Litsea cubeba.Pungent；Bitter；Warm in nature.Gui Jing: spleen；Stomach cures mainly through function: warming middle-JIAO to promote flow of QI pain relieving；Drying damp and strengthening spleen help digestion；Removing toxic substances and promoting subsidence of swelling.Main cold syndrome of the stomach is suffered from abdominal pain；Heat-damp in summer is vomited and diarrhoea；Dyspepsia is glutted；Dysmenorrhea；Colic；Malaria；Skin infection swells and ache." Chongqing medical herbs ": by cold, analgesia, stomach invigorating, disappear glutted.Control heart stomach cold air pain, cold GUFENG, cold food malaria, dysmenorrhea.The intestines and stomach has hot person to avoid use." Hunan medicine will ": dispel the wind, cold expelling.Control the cold stomachache of sense；Fructus Litseae pungentis four to five money.It is decocted in water for oral dose.Control arthralgia: Fructus Litseae pungentis one or two, Realgar five money, chicken droppings two liang.Mash, make popular, cloth bag, rub sore spot.
Folium Artemisiae Argyi returns liver,spleen,kidney warp.Effect warming the meridian for stopping bleeding, dispersing cold for relieving pain；External removing dampness to relieve itching.Curing mainly for spitting blood, epistaxis, metrorrhagia, menorrhagia, vaginal bleeding during pregnancy hematochezia, few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile；External treatment skin pruritus.Vinegar Chinese mugwort charcoal warming the meridian for stopping bleeding is hemorrhage for deficient cold type.
Folium Perillae: Folium Perillae can dissipate exterior cold, diaphoresis power is relatively strong, for wind and cold table disease, sees aversion to cold, heating, the disease such as lossless, often joins Rhizoma Zingiberis Recens with using；As table disease has the stagnation of QI concurrently, have and can be equal to use with Rhizoma Cyperi, Pericarpium Citri Reticulatae.Promoting the circulation of QI to alleviate the stagnation in middle-JIAO Folium Perillae is used for stagnation of QI in spleen and stomach, uncomfortable in chest, vomiting and nausea.Folium Perillae can diaphoresis cold expelling to solve pathogenic factor in the exterior, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, resolving depression preventing or arresting vomiting, therefore double that see symptoms of emesis uncomfortable in chest to wind and cold table disease, use this product, be very suitable；Or have without table disease the smooth symptom of the stagnation of QI it can also be used to a surname is logical.As join Herba Pogostemonis, Pericarpium Citri Reticulatae then induce sweat and in, join the Rhizoma Pinelliae, Cortex Magnoliae Officinalis then resolving depression the chest stuffiness relieving.
Cortex Phellodendri bitter in the mouth, cold in nature.Return through kidney, bladder warp.Function has heat clearing and damp drying, and pathogenic fire purging is except steaming, effect of detoxification sore treatment.Curing mainly for damp-heat dysentery, jaundice dark coloured urine, leukorrhagia pudendal pruritus, the puckery pain of pyretic stranguria, tinea pedis flaccidity is preesed, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema eczema.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.
Radix Sophorae Flavescentis, Chinese medicine name.For the dry root of leguminous plant Radix Sophorae Flavescentis, excavate in spring, season in autumn two, remove root head and little supporting root, cleaning, drying, or take advantage of fresh slices, be dried.It is bitter, cold.There are heat clearing and damp drying, parasite killing, the merit of diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy, external treatment trichomonal vaginitis.
Radix Arnebiae (Radix Lithospermi) function cures mainly: removing heat from blood, invigorates blood circulation, heat clearing away, removing toxic substances.Control warm macule, jaundice due to damp-heat, purpura, tell, be defeated in battle, hematuria, stranguria with turbid discharge, constipation with heat retention, burn, eczema, erysipelas, carbuncle and ulcer." herbal classic ": " main trusted subordinate's pathogen, five types of jaundice, invigorating the spleen and replenishing QI, profit nine orifices, waterway." " not Lu ": " treats abdomen swelling completely pain.To close cream, treat children's's skin ulcer and face acne." " property of medicine opinion ": " controls malignant boil, tinea."
Herba speranskiae tuberculatae, (formal name used at school: Phryma
Leptostachya L. subsp. asiatica (Hara) Kitamura) it is used as medicine partly for plant herb.Green, dry with herb color, matter is tender, free from admixture person is preferred.It is distributed in all parts of the country.It mostly is artificial plantation.Reddish brown with stem color, without leaf, be dried, free from admixture person is preferred.Annual herb flowers, produce the nations of China and India.Property happiness sunlight, be afraid of wet, heat-resisting can not resist cold, suitable be born in loose fertile micro-sour soil earth, but the most barren-resistant.Adaptability is relatively strong, transplants and easily survives, and growth is rapidly.Seed also name Semen Impatientis, stem also name Herba speranskiae tuberculatae, all can be used as medicine, have blood circulation promoting and blood stasis dispelling, diuresis removing toxic substances, deep effect of stimulating the menstrual flow.External application mashed by fresh grass, can control the swollen pain of furuncle, insect-bite.
Radix Saposhnikoviae, Chinese medicine name.Another name copper rue, Hui Yun, return grass, Rhizoma Cibotii, hundred kinds.The name of a kind of medicinal herbs, herbaceos perennial, its nice and cool weather of happiness, cold-resistant, drought-resistant, main product in Hebei, Heilungkiang, Sichuan, the ground such as Inner Mongol.The Gen Kesheng of Radix Saposhnikoviae uses.Acrid in the mouth, sweet, slightly warm in nature.There are expelling pathogenic wind from the body surface, removing dampness to relieve pain, effect of relieving convulsion.
Spina Gleditsiae, Chinese medicine name.Dry Spina jujubae for leguminous plant Fructus Gleditsia Gleditsia sinensis Lam..There is detumescence poison holding, evacuation of pus, effect of parasite killing.Be usually used in carbuncle from the beginning of or difficulty in discharging of pus；External treatment scabies leprosy.Elementary Medicine ": " Spina Gleditsiae, all carbuncle persons of not breaking can have one's ideas straightened out；Do not break person and can reach skin ulcer institute by priming, be all malignant boil tinea and leprosy key medicine also." Compendium of Material Medica: " Fructus Gleditsia acupuncture controls wind parasite killing, and merit is same with pod, the different ear but its sharp keen through disease is done.”
Rhizoma Acori Graminei Herb fragrance, can make spice or mosquito dispersing；Stem, leaf can be used as medicine.Root stock (calamus): bitter, pungent, temperature.Reduce phlegm, have one's ideas straightened out, spleen invigorating, dampness removing.For epilepsy, palpitating with fear forgetful, obnubilation, humidity hysteresis painful abdominal mass is swollen, dysentery, rheumatalgia, carbuncle scabies.Rhizoma Acori Graminei its flower, stem aromatic flavor, have the effect had one's ideas straightened out, eliminate the phlegm, dissipate wind, epidemic disease of can dispelling Fructus Alpiniae Oxyphyllae, building body.The successive dynasties classic of TCM all using Rhizoma Acori Graminei rhizome as Fructus Alpiniae Oxyphyllae the chest stuffiness relieving, hearing-improing and eyesight improving, the medicine of damp eliminating removing toxic substances.
Specific embodiment 1
Flos Caryophylli 1000g, Radix Angelicae Dahuricae 1000g, Herba Menthae 1000g, Rhizoma Acori Graminei 1000g, Herba Moslae 1000g and the Fructus Litseae pungentis 1000g way of distillation are vaporized into crystallization, pulverize stand-by, for component 1；Other raw materials Folium Artemisiae Argyi 1000g, Spina Gleditsiae 1000g, Folium Perillae 1000g, Herba Hedyotidis Diffusae 1000g, Cortex Phellodendri 1000g, Radix Sophorae Flavescentis 1000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1000g, Radix Saposhnikoviae 1000g, Radix Arnebiae (Radix Lithospermi) 1000g, Herba speranskiae tuberculatae 1000g, by soak with ethanol, heated and boiled 3 times, each 1-2 hour, filtering, filtrate is standby；By in the filtrate suction concentrating under reduced pressure tank merging latter 3 times, being evaporated to relative density is 1.20, the concentrated solution of temperature to 60 DEG C-70 DEG C；Become component 2, blending ingredients 1 and component 2, load bottle.The present invention does not contains chemical composition, is difficult to preserve, must cold preservation.
Specific embodiment 2
Just Flos Caryophylli 1200g, Radix Angelicae Dahuricae 1100g, Herba Menthae 1100g, Rhizoma Acori Graminei 1200g, Herba Moslae 1100g and the Fructus Litseae pungentis 1200g way of distillation are vaporized into crystallization, pulverize stand-by, for component 1；Other raw materials Folium Artemisiae Argyi 1100g, Spina Gleditsiae 1200g, Folium Perillae 1200g, Herba Hedyotidis Diffusae 1200g, Cortex Phellodendri 1200g, Radix Sophorae Flavescentis 1100g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1100g, Radix Saposhnikoviae 1200g, Radix Arnebiae (Radix Lithospermi) 1100g, Herba speranskiae tuberculatae 1200g, is soaked and has been placed in lid stainless steel cask, adds 70% ethanol, quality is coarse grained 0.8-1 times, stir, moistening airtight placement more than 1 hour, make fully to expand；By bottom percolator filter plate gauze bag parcel pave after again the drug sample after moistening expansion is mixed pine do dissipate, then powder is contained with rustless steel spoon, load percolator uniformly, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitably pressurization, medicated powder loads 2/3 eminence that must not exceed percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, is then slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, controlling percolation speed and be generally 1000g medical material outflow per minute 2～3ml, filtrate puts into liquid container, and pours ethanol during emptying into liquid container；Percolate is merged and stands, stand for standby use；The filtrate of filtration being inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0～5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml crude drug amount Han 0.1g, for component 2.By component 1 and the merging of component 2, load bottle.The present invention does not contains chemical composition, is difficult to preserve, must cold preservation.
Specifically embodiment 3
First crude drug Flos Caryophylli 1200g, Radix Angelicae Dahuricae 1100g, Herba Menthae 1200g, Rhizoma Acori Graminei 1200g, Herba Moslae 1100g and Fructus Litseae pungentis 1200g steam method is distilled, obtain crystal, then pulverize, cross 100-120 mesh sieve, standby as component 1；Again by remaining crude drug Folium Artemisiae Argyi 1100g, Spina Gleditsiae 1200g, Folium Perillae 1200g, Herba Hedyotidis Diffusae 1200g, Cortex Phellodendri 1200g, Radix Sophorae Flavescentis 1100g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1100g, Radix Saposhnikoviae 1200g, Radix Arnebiae (Radix Lithospermi) 1100g, Herba speranskiae tuberculatae 1200g steeps in 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, united extraction liquid, 100-120 mesh filters, then the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming, the filtrate of 1.25 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, as component 2；Then component 1 being put in component 2, stir, subpackage, the present invention does not contains chemical composition, is difficult to preserve, must cold preservation
External used medicine of the present invention repeatedly Skin Irritation Test result
According to the requirement of DB61-267-1998 " health product Toxicological evaluation program and the method for inspection ", medicine of the present invention is carried out repeatedly Skin Irritation Test.
Tested material: the preparation of the present invention.Weigh tested material 50g to add distilled water to make 50% pastel standby.
Laboratory animal: being provided Japan's white big ear rabbit 4, male and female half and half, body weight 2.5-3.0kg by Shandong University's medical college Experimental Animal Center, primary animal (the dynamic word the 08-018th of doctor), feed resource is ibid.Animal housing's environment: temperature: 22-25 DEG C, relative humidity: 45-55%.The Animal House quality certification number: the dynamic word the 08-37th of doctor.Test method: test first 24 hours, in every rabbit back spinal column both sides cropping preserved skin, each 3cm × 6cm of unhairing scope.Only taking tested material 0.5g/, be coated on the skin of every rabbit side, smear every day once after preparation, offside all makees solvent control.Smear 14d continuously.Cropping before being coated with every day, must not injured skin, it is ensured that tested material is fully contacted with skin.Observe dermoreaction and marking every day.Off-test, takes and smears area skin and carry out histopathologic examination.
Experimental result: repeatedly Skin Irritation Test shows that the present invention the highest stimulation index of repeatedly skin irritation and pathological tissue integration are 0, according to skin irritation strength grading standard in DB61-267-1998 " health product Toxicological evaluation program and the method for inspection ", the present invention repeatedly skin irritation intensity belongs to nonirritant.
Skin anaphylactic test
According to the requirement of DB61-267-1998 " health product Toxicological evaluation program and the method for inspection ", medicine of the present invention is carried out skin anaphylactic test.
Tested material: external preparation of the present invention.Weigh tested material 10g to add distilled water to make 50% pastel standby.Positive control: 2,4-dinitro-chloro-benzenes, Xing Jin chemical plant, Beijing product, lot number 20020522.Laboratory animal: being provided Cavia porcellus 30 by Shandong University's medical college Experimental Animal Center, male and female half and half, body weight 250-300g, primary animal, feed resource is ibid.Animal housing's environment: temperature: 22-25 DEG C, relative humidity: 45-55%.The Animal House quality certification number: the dynamic word the 08-37th of doctor.Test method: test Cavia porcellus is randomly divided into three groups, often group 10, male and female half and half, respectively tested material group, negative control group and positive controls.
Sensitization contact: guinea pig back left of spine hair was removed in first 24 hours to tested material, unhairing scope about 3cm × 3cm.Only take tested material 0.2g/, be coated in depilation district on the left of back part of animal after preparation, continue 6 hours.7th day and fortnight, be repeated once with same method, and positive controls is coated with 1%DNCB, and negative control group does not deals with.Excite contact: fortnight after last is to tested material, by tested material 0.2g/ only, be coated on depilation district on the right side of guinea pig back after preparation, after 6 hours, remove tested material, at once observe anaphylaxis situation, then again observed in 1,24,48,72 hours.Positive controls is coated with 1%DNCB, and negative control group does not deals with.Observational technique is with tested material group.
Result of the test: skin anaphylactic test shows external preparation of the present invention, according to according to sensitization of skin intensity evaluation standard relevant in DB61-267-1998 " health product Toxicological evaluation program and the method for inspection ", the invention belongs to without sensitization.
Pharmacological experiment
1 object and method
1.1 objects 1. material: botanical herbs of the present invention.Prepare as described in Example 2.2. object: white mice, experiment culex are provided by Shandong Prov. Sanitation and Antiepidemic Station.White mice body weight 19～25 g；Test culex is the culex pipiens fatigans of laboratory rearing.Test strain is escherichia coli (bacterial strains number: 8099), Microbiological Lab of Shandong University provide.
1.1.1 white mice repellency test
Test insecticide: culex pipiens fatigans, the female adult culex that after emergence, the 2nd day to the 3rd day does not sucks blood is tested.Condition determination: test chamber temperature 26 27 DEG C, relative humidity 60%.70%, during test, laboratory is airtight light tight.Time: 17:00～23:00.With reference to GB/17322.10 1998 ((indoor harmacological effect of agriculture chemical registration hygienic insecticide evaluates repellant " on the basis of carried out following amendment.Each 100 of people female adult culex is put respectively in 3 mosquito cages of 30 cm × 30, cm × 30 cm.3 white mice planks are fixed, cuts off dorsal body setae, expose the skin of 2 cmX3cm.In the composite granule that 10 g prepare, take out 0.5 g sample be diluted to thick liquid with 2 ml glycerol, 1.5 h before the test, the thick liquid taking 2 part of 0.1 g in the thick liquid prepared uniformly is applied to two white mice shaving positions, and other one is matched group.White mice health remainder coarse cloth wraps up, and 17:00 is respectively put in 3 cages simultaneously, and every 2 h observe once, and each observing time is 5min, persistent period 6 h.As long as test group has 1 mosquito to suck blood i.e. sentences repellent failure.Repellent effect replaces staff to infer this sample effective protecting time to people with white mice.Often before group test, white mice is put into 5min in cage, if mosquito challenge quantity is that mosquito attack is qualified more than 10.Each sample is repeated 2 times, if many group tests are carried out simultaneously, then has only to l group matched group and synchronizes to test.After experiment above is tested, it is subjects further experiment to reaching formula volunteer's the back of the hand of repellent effect in 6 h, so that it is determined that the Effective Vate of Protection to human body.
1.2. human body repellency test
The test of pesticide effectiveness is carried out with reference to GB/T 17322.10 1998 " indoor harmacological effect of agriculture chemical registration hygienic insecticide evaluates repellant " method.Test insecticide, test condition, testing time are the same.By qualified (if the mosquito of test is 300 for 3 attacks, have more than 30 the back of the hand attacking volunteer then to show that the back of the hand attack of this volunteer is qualified in 2 min) volunteer's left hand the back of the hand (3 volunteers) expose the skin of 4 cm × 4 cm, remainder coarse cloth wraps up.0.5 g sample is taken out in the present invention that 10 g prepare, it is diluted to thick liquid with 2 m1 glycerol, 2 h before the test, taking 2 parts in 0.5 thick liquid is respectively that the thick liquid of 0.1 g is coated in 2 volunteer's left hand the back of the hand exposure portion respectively, and left hand the back of the hand of other 1 volunteer is matched group.The back of the hand of volunteer is put in 2 cages being respectively arranged with 300 female adult culexs by 17:00 simultaneously, and every l h observes once, and each observation time is 2min, persistent period 6 h.As long as the test group scribbling thick liquid has 1 mosquito to suck blood i.e. sentences repellent failure.Often before group test, left hand the back of the hand of remaining 1 volunteer as comparison hands and stretches into 2min in cage, if mosquito challenge quantity is that mosquito attack is qualified more than 30 every time.Retest 2 times.If many group tests are carried out simultaneously, the most only need 1 group of matched group.
2 results
2.1 white mice repellency test results
2.1.1 the present invention minimum anophelifuge concentration test result
2.1.1.1 variable concentrations repelling effect of the present invention
The present invention taking 5 concentration respectively carries out repellent test.Going out from the test result analysis of table 1, the content of the present invention just has repellent effect more than 28%, and therefore this content is that the minimum of white mice is protected concentration in 6 h by the present invention completely.
Table 1 present invention is to white mouse variable concentrations repelling effect
2.2 human body repellency test results selections are that the said herbal medicine of 100% (white mice is i.e. attacked the formula that mosquito number is zero) carries out human body repellency test in 6h to white mice protective rate, and the most qualified for the test culex attack of human body repellency test.Test shows, after these formula powder body are made into thick liquid, in 6 h, the number of times of biting testing culex in addition to the present invention of 28% in table 1 is 0.In table 1, the present invention of 28% has 1 mosquito bite at the 5th h, has 2 mosquito bite at the 6th h, then the content of the present invention of 28% in table 1 is risen to 33%, then carry out human body repellent test, without mosquito bite in 6 h.
2.3 Chinese medicines of the present invention press down mattress effect test as can be known from the results of Table 1, even if the content of the present invention is only 2%, it may have certain fungistatic effect, ensure that the present invention has certain bacteria resistance function in theory.Select the Chinese medicine formula powder body in human body repellency test with human body repellent effect to carry out fungistatic effect test, the results are shown in Table 2.
Table 2 fungistatic effect of the present invention
Conclusion: due to this test first with natural Chinese medicine preparation building room health type elementary material, whole process is without any chemical process, thus greatly reduces the load of environment.But, elementary material consumption is excessive, limits its range of application, is only suitable for the simple construction materials such as ceiling.Thus find some effect more preferable medium-height grass and human body can be had certain genetoxic, merit attention.Chinese medicine anophelifuge has certain effect, but the abnormal smells from the patient of Chinese medicine sachet the most just reduces, and often changes guarantee repelling effect.So the Chinese medicine mosquito-driving liquid of concentration extraction, have and prevent mosquito bite, and have no side effect, not injured skin, easy cleaning, spray or put on the skin the greasy feeling being put on skin without uncomfortable, the most do not hinder the secretion of perspiration and sebum, mosquito-proof effect duration is long.There is good market prospect.
Claims (10)
1. a Chinese medicine mosquito-driving liquid, it is characterised in that described Chinese medicine mosquito-driving liquid includes the crude drug of following parts by weight: Folium Artemisiae Argyi 10～20 parts, Spina Gleditsiae 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, Flos Caryophylli 10～20 parts, Herba Menthae 10～20 parts, Folium Perillae 10～20 parts, Rhizoma Acori Graminei 10～20 parts, Herba Hedyotidis Diffusae 10～20 parts, Cortex Phellodendri 10～20 parts, Radix Sophorae Flavescentis 10～20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20 parts, Radix Saposhnikoviae 10～20 parts, Fructus Litseae pungentis 10～20 parts, Radix Arnebiae (Radix Lithospermi) 10～20 parts, Herba Moslae 10～20 parts, Herba speranskiae tuberculatae 10～20 parts.
Chinese medicine mosquito-driving liquid the most according to claim 1, it is characterized in that, described Chinese medicine mosquito-driving liquid also includes the crude drug of following parts by weight: Folium Artemisiae Argyi 10～15 parts, Spina Gleditsiae 10～15 parts, the Radix Angelicae Dahuricae 10～15 parts, Flos Caryophylli 10～15 parts, Herba Menthae 10～15 parts, Folium Perillae 10～15 parts, Rhizoma Acori Graminei 10～15 parts, Herba Hedyotidis Diffusae 10～15 parts, Cortex Phellodendri 10～20 parts, Radix Sophorae Flavescentis 10～20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20 parts, Radix Saposhnikoviae 10～20 parts, Fructus Litseae pungentis 10～20 parts, Radix Arnebiae (Radix Lithospermi) 10～20 parts, Herba Moslae 10～20 parts, Herba speranskiae tuberculatae 10～20 parts.
3. according to Chinese medicine mosquito-driving liquid described in claim 1, it is characterized in that, described Chinese medicine mosquito-driving liquid also includes the crude drug of following parts by weight: Folium Artemisiae Argyi 10～20 parts, Spina Gleditsiae 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, Flos Caryophylli 10～20 parts, Herba Menthae 10～20 parts, Folium Perillae 10～20 parts, Rhizoma Acori Graminei 10～20 parts, Herba Hedyotidis Diffusae 10～20 parts, Cortex Phellodendri 10～15 parts, Radix Sophorae Flavescentis 10～15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～15 parts, Radix Saposhnikoviae 10～15 parts, Fructus Litseae pungentis 10～15 parts, Radix Arnebiae (Radix Lithospermi) 10～15 parts, Herba Moslae 10～15 parts, Herba speranskiae tuberculatae 10～15 parts.
4. the preparation method of Chinese medicine mosquito-driving liquid as according to any one of claims 1 to 3, it is characterised in that the preparation method of described Chinese medicine mosquito-driving liquid comprises the following steps:
A. take Flos Caryophylli, the Radix Angelicae Dahuricae, Herba Menthae, Rhizoma Acori Graminei, Herba Moslae and the Fructus Litseae pungentis way of distillation and be vaporized into crystallization, pulverize dusting cover stand-by, as component 1；
B. the extraction of surplus stock medicinal alcohol is taken, as component 2；
C. by stripped for ethanol medicinal residues soak by water 2 times, concentrated extracting solution is merged, as component 3；
D. by 2-in-1 for component 1 component and be condensed into concentrated solution, it is divided into bottle packaging.
The preparation method of Chinese medicine mosquito-driving liquid the most according to claim 4, it is characterised in that in described step a, first crude drug Flos Caryophylli, the Radix Angelicae Dahuricae, Herba Menthae, Rhizoma Acori Graminei, Herba Moslae and Fructus Litseae pungentis steam method is distilled, obtain crystal, then pulverize, cross 100-120 mesh sieve, standby as component 1.
The preparation method of Chinese medicine mosquito-driving liquid the most according to claim 4, it is characterized in that, in described step b, remaining crude drug is shredded, is soaked and be placed in lid stainless steel cask, add 70% ethanol, quality is coarse grained 0.8-1 times, stir, moistening airtight placement more than 1 hour, make fully to expand；By bottom percolator filter plate gauze bag parcel pave after again the drug sample after moistening expansion is mixed pine do dissipate, then powder is contained with rustless steel spoon, load percolator uniformly, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitably pressurization, medicated powder loads 2/3 eminence that must not exceed percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, is then slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, controlling percolation speed and be generally 1000g medical material outflow per minute 2～3ml, filtrate puts into liquid container, and pours ethanol during emptying into liquid container；Being merged by percolate and stand, stand for standby use, as component 2.
The preparation method of Chinese medicine mosquito-driving liquid the most according to claim 4, it is characterised in that in described step c, above-mentioned stripped raw material residue is put in 10 times amount water, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, united extraction liquid, 100-120 mesh filters, then the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming, the filtrate of 1.05 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, as component 3.
The preparation method of Chinese medicine mosquito-driving liquid the most according to claim 4, in described step d, component 2 is merged with component 3, put in economic benefits and social benefits vacuum concentrator and mix, first concentrating the filtrate to relative density when 80 DEG C is the concentrated solution of 1.32, sets to 0～5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr that cold preservation liquid is added 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml concentrated solution Han 0.1g, add component 1 stir sub-bottle load, the present invention do not contain chemical composition, be difficult to preserve, palpus cold preservation.
9. the preparation method of Chinese medicine mosquito-driving liquid as according to any one of claims 1 to 3, it is characterised in that the preparation process of described Chinese medicine mosquito-driving liquid can also be:
A. take Flos Caryophylli, the Radix Angelicae Dahuricae, Herba Menthae, Rhizoma Acori Graminei, Herba Moslae and the Fructus Litseae pungentis way of distillation and be vaporized into crystallization, pulverize dusting cover stand-by, as component 1；
B. by remaining raw material ethanol extraction 2 times, concentrate, as component 2；
C. after component 1, component 2 uniformly being mixed, subpackage.
The preparation method of Chinese medicine mosquito-driving liquid the most according to claim 9, it is characterised in that in described step a, first crude drug Flos Caryophylli, the Radix Angelicae Dahuricae, Herba Menthae, Rhizoma Acori Graminei, Herba Moslae and Fructus Litseae pungentis steam method is distilled, obtain crystal, then pulverize, cross 100-120 mesh sieve, standby as component 1；In described step b, remaining crude drug is steeped in 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, united extraction liquid, 100-120 mesh filters, then the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming, the filtrate of 1.25 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, as component 2；In described step c, component 1 being put in component 2, stir, subpackage, the present invention does not contains chemical composition, is difficult to preserve, must cold preservation.
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