CN105831181A - Safe environment-friendly mosquito-repellent incense solution and preparation method thereof - Google Patents
Safe environment-friendly mosquito-repellent incense solution and preparation method thereof Download PDFInfo
- Publication number
- CN105831181A CN105831181A CN201610191748.3A CN201610191748A CN105831181A CN 105831181 A CN105831181 A CN 105831181A CN 201610191748 A CN201610191748 A CN 201610191748A CN 105831181 A CN105831181 A CN 105831181A
- Authority
- CN
- China
- Prior art keywords
- parts
- herba
- environmental protection
- component
- safety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/18—Vapour or smoke emitting compositions with delayed or sustained release
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/40—Liliopsida [monocotyledons]
- A01N65/44—Poaceae or Gramineae [Grass family], e.g. bamboo, lemon grass or citronella grass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/09—Lichens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/748—Oldenlandia or Hedyotis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Dermatology (AREA)
- Pest Control & Pesticides (AREA)
- Toxicology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a safe environment-friendly mosquito-repellent incense solution and a preparation method thereof. The mosquito-repellent incense solution comprises the following raw materials by weight: 5 to 12 parts of Artemisia argyi, 6 to 16 parts of Bauhinia variegata, 10 to 20 parts of mint, 5 to 15 parts of Cymbopogon distans, 5 to 18 parts of Cladonia alpestris, 9 to 16 parts of Eupatorium fortunei, 5 to 18 parts of perilla, 6 to 15 parts of calamus, 2 to 8 parts of heydyotis, 2 to 10 parts of phellodendron bark, 10 to 20 parts of divaricate saposhnikovia root, 3 to 9 parts of common perilla leaf, 10 to 16 parts of muskroot-like semiaquilegia herb, 5 to 18 parts of Spilanthes acmella, 10 to 20 parts of pungent litse fruit, 10 to 20 parts of lithospermum, 10 to 20 parts of aromatic madder, 10 to 20 parts of herb of tuberculate speranskia, 2 to 15 parts of Chinese febervine herb and 5 to 15 parts of Indian azalea leaf. The mosquito-repellent incense solution can prevent mosquito bites, is free of toxic and side effect and easy to clean, does not damage skin or lead to uncomfortable greasy feeling when sprayed or smeared on skin, exerts no influence on secretion of sweat and sebum and has a long action period in repelling mosquitoes.
Description
Technical field
The present invention relates to a kind of safety and environmental protection mosquito incense liquid and preparation method.
Background technology
Summer, mosquito wreaked havoc, and estimation is the problem that everyone is worried.Along with electric mosquito-repellent incense, the application of mosquito-driving liquid, certain effect is striking.But electric mosquito repellent liquid has certain toxicity, everybody it should be appreciated that these invisible chemical gas that also can't smell that can not touch, is not distributing toxin, is accumulating over a long period and encroach on our health.Along with the Continued of temperature, mosquito starts to haunt the most gradually, and many health preserving intelligents start to shine the self-control anophelifuge equipment of oneself in online microblogging, wechat, invite many online friends to imitate.But, also someone queries these and equips equipped with the anophelifuge of Chinese medicine and really have repelling effect, even worries medical herbs therein whether toxic side effect.
Chinese herbal medicine Anti-mosquito disinsectization is not any strange thing, in the history of the existing more than one thousand years of China, mainly holds anophelifuge medical material with sachet, body-worn or be placed in room.The Chinese herbal medicine such as the Rhizoma Acori Graminei that often comprises in the sachet of general anophelifuge, Folium Artemisiae Argyi, the Radix Angelicae Dahuricae, Herba Eupatorii, Herba Menthae, Herba Pogostemonis, these broadly fall into fragrance medicine, containing volatile oil, can volatilize the taste that mosquito does not likes under natural environment, so repelling effect can be reached.
Effect that some Chinese medicines have " fragrance is warded off turbid " is also had in general authentic anophelifuge sachet.Such as Rhizoma Acori Graminei, the Radix Angelicae Dahuricae etc. can suppress fungus effectively, have suppression virus and bactericidal action, and Herba Moslae etc. helps relieves summer heat and warming the stomach, help the anorexia that prevention summer fever causes for child.Additionally some medical herbs also has calm soporific function.
The medicine of the pungent fragrant class in some anophelifuge sachets is more, and for anemia of pregnant woman, especially conceived first trimester is not suitable for long-term body-worn, otherwise may cause the adverse consequencess such as habitual abortion.Anophelifuge medical herbs is many containing aromatic substance with volatile oil, these are all that the people of allergic constitution should use with caution, body constitution difference according to individual, likely cause skin and mucous membrane hypersusceptibility reaction, so the crowd of allergic constitution is also not suitable for next to the skin wearing, hang over evening in the head of a bed or mosquito net, it is to avoid directly contact skin causes the situation of allergy as far as possible.It is pointed out that can be the most mosquito-proof by the physical isolation mode such as mosquito net screen window, only the most limited by sachet expelling mosquito effect.
Chinese medicine anophelifuge has certain effect, but the abnormal smells from the patient of Chinese medicine sachet the most just reduces, and often changes guarantee repelling effect.So the Chinese medicine mosquito-driving liquid of concentration extraction, have and prevent mosquito bite, and have no side effect, not injured skin, easy cleaning, spray or put on the skin the greasy feeling being put on skin without uncomfortable, the most do not hinder the secretion of perspiration and sebum, mosquito-proof effect duration is long.There is good market prospect.
Summary of the invention
The technical problem to be solved is, it is provided that the mosquito incense liquid of a kind of safety and environmental protection and preparation method, relative chemical mosquito-driving liquid strong toxicity, and big to human injury, Chinese medicine repelling effect can not be lasting.Find one to have and prevent mosquito bite, and have no side effect, not injured skin, easy cleaning, spray or put on the skin the greasy feeling being put on skin without uncomfortable, the most do not hinder the secretion of perspiration and sebum, the product of mosquito-proof effect duration length.
The solution of the present invention is as follows: a kind of safety and environmental protection mosquito incense liquid, described safety and environmental protection mosquito incense liquid includes the crude drug of following parts by weight: Folium Artemisiae Argyi 5～12 parts, Flos Bauhiniae Variegatae 6-16 part, Herba Menthae 10～20 parts, Herba Cymbopogonis 5～15 parts, Cladonia alpestris (L.) Rabenh. 8～22 points, Herba Eupatorii 9～16 parts, Folium Perillae 5～18 parts, Rhizoma Acori Graminei 6～15 parts, Herba Hedyotidis Diffusae 2～8 parts, Cortex Phellodendri 2～10 parts, Radix Saposhnikoviae 10～20 parts, Folium Perillae Frutescentis 3～9 parts, Radix Semiaquilegiae 10～16 parts, Herba Spilanthis Acmellae 5～18 parts, Fructus Litseae pungentis 10～20 parts, Radix Arnebiae (Radix Lithospermi) 10～20 parts, Herba Moslae 10～20 parts, Herba speranskiae tuberculatae 10～20 parts, fevervine 2～15 parts, Flos Rhododendri Arborei 5～15 parts.
Further, described safety and environmental protection mosquito incense liquid also includes the crude drug of following parts by weight: Folium Artemisiae Argyi 8～12 parts, Flos Bauhiniae Variegatae 8～12 parts, Herba Menthae 10～15 parts, Herba Cymbopogonis 8～15 parts, Cladonia alpestris (L.) Rabenh. 10～16 points, Herba Eupatorii 10～15 parts, Folium Perillae 8～12 parts, Rhizoma Acori Graminei 8～15 parts, Herba Hedyotidis Diffusae 2～8 parts, Cortex Phellodendri 4～9 parts, Radix Saposhnikoviae 12～20 parts, Folium Perillae Frutescentis 5～9 parts, Radix Semiaquilegiae 12～16 parts, Herba Spilanthis Acmellae 5～18 parts, Fructus Litseae pungentis 10～20 parts, Radix Arnebiae (Radix Lithospermi) 15～20 parts, Herba Moslae 12～20 parts, Herba speranskiae tuberculatae 12～16 parts, fevervine 5～10 parts, Flos Rhododendri Arborei 5～15 parts.
Further, described safety and environmental protection mosquito incense liquid also includes the crude drug of following parts by weight: Folium Artemisiae Argyi 10 parts, Flos Bauhiniae Variegatae 9 parts, Herba Menthae 12 parts, Herba Cymbopogonis 9 parts, Cladonia alpestris (L.) Rabenh. 15 points, Herba Eupatorii 12 parts, Folium Perillae 10 parts, Rhizoma Acori Graminei 9 parts, Herba Hedyotidis Diffusae 5 parts, Cortex Phellodendri 8 parts, Radix Saposhnikoviae 16 parts, Folium Perillae Frutescentis 8 parts, Radix Semiaquilegiae 15 parts, Herba Spilanthis Acmellae 6 parts, Fructus Litseae pungentis 16 parts, Radix Arnebiae (Radix Lithospermi) 18 parts, Herba Moslae 13 parts, Herba speranskiae tuberculatae 15 parts, fevervine 6 parts, Flos Rhododendri Arborei 10 parts.
A kind of preparation method of safety and environmental protection mosquito incense liquid, the preparation method of described safety and environmental protection mosquito incense liquid comprises the following steps:
A. take Flos Bauhiniae Variegatae, Herba Cymbopogonis, Herba Menthae, Rhizoma Acori Graminei, Herba Moslae and the fevervine way of distillation and be vaporized into crystallization, pulverize dusting cover stand-by, as component one.
B. the extraction of surplus stock medicinal alcohol is taken, as component two；
C. by stripped for ethanol medicinal residues soak by water 2 times, concentrated extracting solution is merged, as component three；
D. component one, component two and component three are merged and be condensed into concentrated solution, be divided into bottle packaging.
Further, in described step a, first crude drug Flos Bauhiniae Variegatae, Herba Cymbopogonis, Herba Menthae, Rhizoma Acori Graminei, Herba Moslae and fevervine steam method is distilled, obtain crystal, then pulverize, cross 100-120 mesh sieve, standby as component one.
Further, in described step b, being shredded by remaining crude drug, soaked and be placed in lid stainless steel cask, add 70% ethanol, quality is coarse grained 0.8-1 times, stirs, moistening airtight placement more than 1 hour, makes fully to expand；By bottom percolator filter plate gauze bag parcel pave after again the drug sample after moistening expansion is mixed pine do dissipate, then powder is contained with rustless steel spoon, load percolator uniformly, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitably pressurization, medicated powder loads 2/3 eminence that must not exceed percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, is then slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, controlling percolation speed and be generally 1000g medical material outflow per minute 2～3ml, filtrate puts into liquid container, and pours ethanol during emptying into liquid container；Being merged by percolate and stand, stand for standby use, as component two.
Further, in described step c, above-mentioned stripped raw material residue is put in 10 times amount water, soaks 1-2 hour, heating extraction 2 times, 1-2 hour every time, remove supernatant, united extraction liquid, 100-120 mesh filters, the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming again, the filtrate of 1.05 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, as component three.
Further, first component two being merged with component three, put in economic benefits and social benefits vacuum concentrator and mix, first concentrating the filtrate to relative density when 80 DEG C is the concentrated solution of 1.32, sets to 0～5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr that cold preservation liquid is added 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml concentrated solution Han 0.1g, add component one stir sub-bottle loading.
Chinese medicine includes mineral drug, animal drugs and plant amedica (Chinese herbal medicine), and wherein plant amedica is then to use most class Chinese medicine.About the research of plant amedica disinsectization performance, domestic main employing extracts deworm, the most also has the substantial amounts of research about plant amedica extract anthelmintic.And relate generally to extract kill parasite of human particularly with regard to Chinese medicine Pericarpium Zanthoxyli, Folium Artemisiae Argyi, Nicotiana tabacum L. Tapeworm canine, and Research Literature is less.Consult part Research Literature and find that Pericarpium Zanthoxyli decoct can resist the insecticides such as trichomonal vaginitis, lethal confused flour beetle adult, honeycomb worm, beet armyworm female adult worm, and Coptotermes formosanus Shtrari., Blatta seu periplaneta, housefly.There is scholar, with Folium Artemisiae Argyi extract, beet armyworm female adult worm has been carried out deterrent effect research, find that the repellent rate effect of beet armyworm be there are differences by extract and different fractions.Folium Artemisiae Argyi extract also has repellent effect to mosquito midge, and the use of Nicotiana tabacum L. anthelmintic is primarily present among folks of china, the most detailed research.Can be seen that from these results of study and thinking, Most scholars uses the method for effective component extracting that Chinese herbal medicine is carried out insect-expelling function research, although gained Effective Component of Chinese Medicine can quickly kill or mosquito repellent, but, the pollutant that a large amount of chemical drugss consumed during extraction and Chinese herbal medicine stay, but bring huge injury to environment for human survival.And, Chinese herbal medicine internal some can the component of comprehensive function anthelmintic can lose during extracting, cause insecticide that single medicine is produced drug resistance effect, and then ineffective.Present invention preparation has antibacterial and synthesis, is similar to the elementary material that " gene chip " combines, compound anthelmintic, and combines as a functional part and play its antibacterial, function for expelling pests in building materials.Compared with existing anthelmintic building materials, cost and carrying capacity of environment will greatly reduce, and lasting effect increases, and insecticide is difficult to develop immunity to drugs.
Folium Artemisiae Argyi: return liver,spleen,kidney warp.Effect warming the meridian for stopping bleeding, dispersing cold for relieving pain；External removing dampness to relieve itching.Curing mainly for spitting blood, epistaxis, metrorrhagia, menorrhagia, vaginal bleeding during pregnancy hematochezia, few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile；External treatment skin pruritus.Vinegar Chinese mugwort charcoal warming the meridian for stopping bleeding is hemorrhage for deficient cold type.
Flos Bauhiniae Variegatae: pained is flat." choosing of Simao, Yunnan Chinese herbal medicine ": eliminating inflammation and expelling toxin.Treating the liver is scorching, pneumonia, tracheobronchitis, cough due to lung-heat.
Herba Menthae: Herba Menthae is one of China's conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls influenza, the disease such as headache, conjunctival congestion, fever of the body, throat, dental bed swell and ache.External can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc..Usually with Herba Menthae for tea, clear away heart-fire improving eyesight.
Herba Cymbopogonis: temperature, acrid in the mouth is nontoxic.Induce sweat, dampness removing, relieving asthma, cough-relieving.The summer-heat that cures the wound is caught a cold, gonorrhea, and rheumatism muscles and bones is ached, chronic tracheitis.
Cladonia alpestris (L.) Rabenh.: property is put down, lightly seasoned.Suppressing the hyperactive liver, stomach invigorating, regulating menstruation, hemostasis.Control vascular hypertension, have a dizzy spell, migraine, mesh disease, asthenia, epistaxis, leucorrhea, menoxenia.
Herba Eupatorii: pungent, flat.Enter spleen, stomach warp.Clearing away summer-heat, wards off dirty, removing dampness, regulating menstruation.Controlling and experience heat-damp in summer, cold and heat are had a headache, and accumulate in damp, and gastral cavity painful abdominal mass is the most hungry, sweet taste in the mouth greasy fur, menoxenia.
Folium Perillae: purple Folium Perillae Frutescentis can dissipate exterior cold, diaphoresis power is relatively strong, for wind and cold table disease, sees aversion to cold, heating, the disease such as lossless, often joins Rhizoma Zingiberis Recens use together；As table disease has the stagnation of QI concurrently, have and can be equal to use with Rhizoma Cyperi, Pericarpium Citri Reticulatae.Promoting the circulation of QI to alleviate the stagnation in middle-JIAO purple Folium Perillae Frutescentis is used for stagnation of QI in spleen and stomach, uncomfortable in chest, vomiting and nausea.Folium Perillae can diaphoresis cold expelling to solve pathogenic factor in the exterior, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, resolving depression preventing or arresting vomiting, therefore double that see symptoms of emesis uncomfortable in chest to wind and cold table disease, use this product, be very suitable；Or have without table disease the smooth symptom of the stagnation of QI it can also be used to a surname is logical.
Rhizoma Acori Graminei: Herb fragrance, can make spice or mosquito dispersing；Stem, leaf can be used as medicine.Root stock (calamus): bitter, pungent, temperature.Reduce phlegm, have one's ideas straightened out, spleen invigorating, dampness removing.For epilepsy, palpitating with fear forgetful, obnubilation, humidity hysteresis painful abdominal mass is swollen, dysentery, rheumatalgia, carbuncle scabies.Rhizoma Acori Graminei its flower, stem aromatic flavor, have the effect had one's ideas straightened out, eliminate the phlegm, dissipate wind, epidemic disease of can dispelling Fructus Alpiniae Oxyphyllae, building body.The successive dynasties classic of TCM all using Rhizoma Acori Graminei rhizome as Fructus Alpiniae Oxyphyllae the chest stuffiness relieving, hearing-improing and eyesight improving, the medicine of damp eliminating removing toxic substances.
Herba Hedyotidis Diffusae: sweet, light is cool.Heat-clearing and toxic substances removing, dampness removing eliminating carbuncle, anticancer.For malignant tumor, acute appendicitis, laryngopharynx swelling and pain, jaundice due to damp-heat, dysuria, furuncle toxic swelling, its patent medicine bitter in the mouth of venom, light, cold in nature.Primary efficacy is heat-clearing and toxic substances removing, medicinal powder for relieving pain knot, promoting urination to remove dampness.Outstanding kind treatment all kinds inflammation.In clinical practice, if finding, Herba Hedyotidis Diffusae compatibility is proper, can treat multiple disease.
Cortex Phellodendri: bitter in the mouth, cold in nature.Return through kidney, bladder warp.Function has heat clearing and damp drying, and pathogenic fire purging is except steaming, effect of detoxification sore treatment.Curing mainly for damp-heat dysentery, jaundice dark coloured urine, leukorrhagia pudendal pruritus, the puckery pain of pyretic stranguria, tinea pedis flaccidity is preesed, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema eczema.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.
Radix Saposhnikoviae: Chinese medicine name.Another name copper rue, Hui Yun, return grass, Rhizoma Cibotii, hundred kinds.The name of a kind of medicinal herbs, herbaceos perennial, its nice and cool weather of happiness, cold-resistant, drought-resistant, main product in Hebei, Heilungkiang, Sichuan, the ground such as Inner Mongol.The Gen Kesheng of Radix Saposhnikoviae uses.Acrid in the mouth, sweet, slightly warm in nature.There are expelling pathogenic wind from the body surface, removing dampness to relieve pain, effect of relieving convulsion.
Folium Perillae Frutescentis: acrid in the mouth, warm in nature, nontoxic.Start with, meridian of Foot-TAI YIN.Induce sweat, cold expelling, regulate the flow of vital energy, help digestion.Cure cold wind and cold, fever with aversion to cold, cough, asthma, and food stagnation is vomited and diarrhoea, cold-dysentery.
Radix Semiaquilegiae: " sweet, cold.Detumescence；Removing toxic substances, diuretic.Control scrofula, hernia, dysuria." Chinese herbal medicine is commonly used in Shanghai ": " heat-clearing and toxic substances removing, diuresis.Control scrofula to steal, toxic swelling, venom, lithangiuria.
Herba Spilanthis Acmellae: arduous, tepor, slightly poisonous.Relieving cough and relieving asthma, reducing swelling and alleviating pain.Cure cold cough, chronic bronchitis, asthma, pertussis, pulmonary tuberculosis, venom, sore swollen toxin, toothache.
Fructus Litseae pungentis: English name: FruitofPungentLitse, FruitofFourflowerLitse, PungentLitse, another name: Fructus Linderae Glaucae, Litsea chenii, Litsea cubeba.Pungent；Bitter；Warm in nature.Gui Jing: spleen；Stomach cures mainly through function: warming middle-JIAO to promote flow of QI pain relieving；Drying damp and strengthening spleen help digestion；Removing toxic substances and promoting subsidence of swelling.Main cold syndrome of the stomach is suffered from abdominal pain；Heat-damp in summer is vomited and diarrhoea；Dyspepsia is glutted；Dysmenorrhea；Colic；Malaria；Skin infection swells and ache." Chongqing medical herbs ": by cold, analgesia, stomach invigorating, disappear glutted.Control heart stomach cold air pain, cold GUFENG, cold food malaria, dysmenorrhea.The intestines and stomach has hot person to avoid use." Hunan medicine will ": dispel the wind, cold expelling.Control the cold stomachache of sense；Fructus Litseae pungentis four to five money.It is decocted in water for oral dose.Control arthralgia: Fructus Litseae pungentis one or two, Realgar five money, chicken droppings two liang.Mash, make popular, cloth bag, rub sore spot.
Radix Arnebiae (Radix Lithospermi): bitter, cold.Enter percardium, Liver Channel.Removing heat from blood, invigorates blood circulation, heat clearing away, removing toxic substances.Control warm macule, jaundice due to damp-heat, purpura, tell, be defeated in battle, hematuria, stranguria with turbid discharge, constipation with heat retention, burn, eczema, erysipelas, carbuncle and ulcer.
Herba Moslae: pungent, tepor.Enter lung, stomach warp.Diaphoresis expelling summer-heat, row water wet dissipation, during stomach warming is adjusted.Controlling Xia Yue sense cold fluid-retention cold, have a headache and fever, aversion to cold is lossless, and the feeling of stuffiness in chest is suffered from abdominal pain, vomiting and diarrhoea, edema, tinea pedis.
Herba speranskiae tuberculatae: (formal name used at school: Phryma leptostachya L. subsp. asiatica (Hara)
Kitamura) part of being used as medicine is plant herb.Green, dry with herb color, matter is tender, free from admixture person is preferred.It is distributed in all parts of the country.It mostly is artificial plantation.Reddish brown with stem color, without leaf, be dried, free from admixture person is preferred.Annual herb flowers, produce the nations of China and India.Property happiness sunlight, be afraid of wet, heat-resisting can not resist cold, suitable be born in loose fertile micro-sour soil earth, but the most barren-resistant.Adaptability is relatively strong, transplants and easily survives, and growth is rapidly.Seed also name Semen Impatientis, stem also name Herba speranskiae tuberculatae, all can be used as medicine, have blood circulation promoting and blood stasis dispelling, diuresis removing toxic substances, deep effect of stimulating the menstrual flow.External application mashed by fresh grass, can control the swollen pain of furuncle, insect-bite.
Fevervine: property is put down, sweet in the mouth, micro-hardship.Expelling wind and removing dampness, analgesic antidotal, promoting digestion and removing stagnation, promoting blood circulation and detumescence.The leukopenia caused for bones and muscles pain due to rheumatism, traumatic injury, traumatic pain, liver and gall and gastrointestinal angor, dyspepsia, infantile malnutrition, bronchus fire, radiation reaction；External dermatitis, eczema and sore swollen toxin.
Flos Rhododendri Arborei: cool in nature, bitter in the mouth, slightly poisonous.Relieving asthma, heat clearing away, draw out pus by applying a plaster to the affected part, hemostasis, regulating menstruation.Control chronic bronchitis, osteomyelitis, digestive tract hemorrhage, epistaxis, spitting of blood, menoxenia.
The present invention has and prevents mosquito bite, and has no side effect, not injured skin, easy cleaning, sprays or puts on the skin the greasy feeling being put on skin without uncomfortable, the most do not hinder the secretion of perspiration and sebum, and mosquito-proof effect duration is long.Coordinating Flos Rhododendri Arborei, Herba Cymbopogonis, the present invention also has certain therapeutic effect to cough with asthma patient.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
Embodiment 1
Folium Artemisiae Argyi 10 parts, Flos Bauhiniae Variegatae 9 parts, Herba Menthae 12 parts, Herba Cymbopogonis 9 parts, Cladonia alpestris (L.) Rabenh. 15 points, Herba Eupatorii 12 parts, Folium Perillae 10 parts, Rhizoma Acori Graminei 9 parts, Herba Hedyotidis Diffusae 5 parts, Cortex Phellodendri 8 parts, Radix Saposhnikoviae 16 parts, Folium Perillae Frutescentis 8 parts, Radix Semiaquilegiae 15 parts, Herba Spilanthis Acmellae 6 parts, Fructus Litseae pungentis 16 parts, Radix Arnebiae (Radix Lithospermi) 18 parts, Herba Moslae 13 parts, Herba speranskiae tuberculatae 15 parts, fevervine 6 parts, Flos Rhododendri Arborei 10 parts.
Preparation method:
The most first crude drug Flos Bauhiniae Variegatae, Herba Cymbopogonis, Herba Menthae, Rhizoma Acori Graminei, Herba Moslae and fevervine steam method is distilled, obtain crystal, then pulverize, cross 100-120 mesh sieve, standby as component one.
B. being shredded by remaining crude drug, soaked and be placed in lid stainless steel cask, add 70% ethanol, quality is coarse grained 0.8-1 times, stirs, moistening airtight placement more than 1 hour, makes fully to expand；By bottom percolator filter plate gauze bag parcel pave after again the drug sample after moistening expansion is mixed pine do dissipate, then powder is contained with rustless steel spoon, load percolator uniformly, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitably pressurization, medicated powder loads 2/3 eminence that must not exceed percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, is then slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, controlling percolation speed and be generally 1000g medical material outflow per minute 2～3ml, filtrate puts into liquid container, and pours ethanol during emptying into liquid container；Being merged by percolate and stand, stand for standby use, as component two.
C. above-mentioned stripped raw material residue is put in 10 times amount water, soak 1-2 hour, heating extraction 2 times, 1-2 hour every time, remove supernatant, united extraction liquid, 100-120 mesh filters, the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming again, the filtrate of 1.05 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, as component three.
The most first component two being merged with component three, put in economic benefits and social benefits vacuum concentrator and mix, first concentrating the filtrate to relative density when 80 DEG C is the concentrated solution of 1.32, sets to 0～5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr that cold preservation liquid is added 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml concentrated solution Han 0.1g, add component one stir sub-bottle loading.
Embodiment 2
Folium Artemisiae Argyi 8 parts, Flos Bauhiniae Variegatae 8 parts, Herba Menthae 10 parts, Herba Cymbopogonis 6 parts, Cladonia alpestris (L.) Rabenh. 20 points, Herba Eupatorii 12 parts, Folium Perillae 6 parts, Rhizoma Acori Graminei 8 parts, Herba Hedyotidis Diffusae 5 parts, Cortex Phellodendri 9 parts, Radix Saposhnikoviae 10 parts, Folium Perillae Frutescentis 4 parts, Radix Semiaquilegiae 12 parts, Herba Spilanthis Acmellae 9 parts, Fructus Litseae pungentis 15 parts, Radix Arnebiae (Radix Lithospermi) 12 parts, Herba Moslae 15 parts, Herba speranskiae tuberculatae 16 parts, fevervine 10 parts, Flos Rhododendri Arborei 8 parts.
Preparation method is with embodiment 1.
Embodiment 3
Folium Artemisiae Argyi 10 parts, Flos Bauhiniae Variegatae 8 parts, Herba Menthae 16 parts, Herba Cymbopogonis 12 parts, Cladonia alpestris (L.) Rabenh. 10 points, Herba Eupatorii 9 parts, Folium Perillae 6 parts, Rhizoma Acori Graminei 12 parts, Herba Hedyotidis Diffusae 7 parts, Cortex Phellodendri 3 parts, Radix Saposhnikoviae 15 parts, Folium Perillae Frutescentis 6 parts, Radix Semiaquilegiae 12 parts, Herba Spilanthis Acmellae 12 parts, Fructus Litseae pungentis 13 parts, Radix Arnebiae (Radix Lithospermi) 15 parts, Herba Moslae 16 parts, Herba speranskiae tuberculatae 14 parts, fevervine 7 parts, Flos Rhododendri Arborei 9 parts.
Preparation method is with embodiment 1.
External used medicine of the present invention repeatedly Skin Irritation Test result
According to the requirement of DB61-267-1998 " health product Toxicological evaluation program and the method for inspection ", medicine of the present invention is carried out repeatedly Skin Irritation Test.
Tested material: the preparation of the present invention.Weigh tested material 50g to add distilled water to make 50% pastel standby.
Laboratory animal: being provided Japan's white big ear rabbit 4, male and female half and half, body weight 2.5-3.0kg by Shandong University's medical college Experimental Animal Center, primary animal (the dynamic word the 08-018th of doctor), feed resource is ibid.Animal housing's environment: temperature: 22-25 DEG C, relative humidity: 45-55%.The Animal House quality certification number: the dynamic word the 08-37th of doctor.Test method: test first 24 hours, in every rabbit back spinal column both sides cropping preserved skin, each 3cm × 6cm of unhairing scope.Only taking tested material 0.5g/, be coated on the skin of every rabbit side, smear every day once after preparation, offside all makees solvent control.Smear 14d continuously.Cropping before being coated with every day, must not injured skin, it is ensured that tested material is fully contacted with skin.Observe dermoreaction and marking every day.Off-test, takes and smears area skin and carry out histopathologic examination.
Experimental result: repeatedly Skin Irritation Test shows that the present invention the highest stimulation index of repeatedly skin irritation and pathological tissue integration are 0, according to skin irritation strength grading standard in DB61-267-1998 " health product Toxicological evaluation program and the method for inspection ", the present invention repeatedly skin irritation intensity belongs to nonirritant.
Skin anaphylactic test
According to the requirement of DB61-267-1998 " health product Toxicological evaluation program and the method for inspection ", medicine of the present invention is carried out skin anaphylactic test.
Tested material: external preparation of the present invention.Weigh tested material 10g to add distilled water to make 50% pastel standby.Positive control: 2,4-dinitro-chloro-benzenes, Xing Jin chemical plant, Beijing product, lot number 20020522.Laboratory animal: being provided Cavia porcellus 30 by Shandong University's medical college Experimental Animal Center, male and female half and half, body weight 250-300g, primary animal, feed resource is ibid.Animal housing's environment: temperature: 22-25 DEG C, relative humidity: 45-55%.The Animal House quality certification number: the dynamic word the 08-37th of doctor.Test method: test Cavia porcellus is randomly divided into three groups, often group 10, male and female half and half, respectively tested material group, negative control group and positive controls.
Sensitization contact: guinea pig back left of spine hair was removed in first 24 hours to tested material, unhairing scope about 3cm × 3cm.Only take tested material 0.2g/, be coated in depilation district on the left of back part of animal after preparation, continue 6 hours.7th day and fortnight, be repeated once with same method, and positive controls is coated with 1%DNCB, and negative control group does not deals with.Excite contact: fortnight after last is to tested material, by tested material 0.2g/ only, be coated on depilation district on the right side of guinea pig back after preparation, after 6 hours, remove tested material, at once observe anaphylaxis situation, then again observed in 1,24,48,72 hours.Positive controls is coated with 1%DNCB, and negative control group does not deals with.Observational technique is with tested material group.
Result of the test: skin anaphylactic test shows external preparation of the present invention, according to according to sensitization of skin intensity evaluation standard relevant in DB61-267-1998 " health product Toxicological evaluation program and the method for inspection ", the invention belongs to without sensitization.
Pharmacological experiment
1 object and method
1.1 objects 1. material: botanical herbs of the present invention.Prepare as described in Example 1.2. object: white mice, experiment culex are provided by Shandong Prov. Sanitation and Antiepidemic Station.White mice body weight 19～25 g；Test culex is the culex pipiens fatigans of laboratory rearing.Test strain is escherichia coli (bacterial strains number: 8099), Microbiological Lab of Shandong University provide.
1.1.1 white mice repellency test
Test insecticide: culex pipiens fatigans, the female adult culex that after emergence, the 2nd day to the 3rd day does not sucks blood is tested.Condition determination: test chamber temperature 26 27 DEG C, relative humidity 60%.70%, during test, laboratory is airtight light tight.Time: 17:00～23:00.With reference to GB/17322.10 1998 ((indoor harmacological effect of agriculture chemical registration hygienic insecticide evaluates repellant " on the basis of carried out following amendment.Each 100 of people female adult culex is put respectively in 3 mosquito cages of 30cm × 30cm × 30cm.3 white mice planks are fixed, cuts off dorsal body setae, expose the skin of 2cmX3cm.Taking out 0.5g sample 2ml glycerol in the composite granule that 10 g prepare and be diluted to thick liquid, 1.5 h before the test, the thick liquid taking 2 part of 0.1 g in the thick liquid prepared uniformly is applied to two white mice shaving positions, and other one is matched group.White mice health remainder coarse cloth wraps up, and 17:00 is respectively put in 3 cages simultaneously, and every 2 h observe once, and each observing time is 5min, persistent period 6h.As long as test group has 1 mosquito to suck blood i.e. sentences repellent failure.Repellent effect replaces staff to infer this sample effective protecting time to people with white mice.Often before group test, white mice is put into 5min in cage, if mosquito challenge quantity is that mosquito attack is qualified more than 10.Each sample is repeated 2 times, if many group tests are carried out simultaneously, then has only to l group matched group and synchronizes to test.After experiment above is tested, it is subjects further experiment to reaching formula volunteer's the back of the hand of repellent effect in 6 h, so that it is determined that the Effective Vate of Protection to human body.
1.2. human body repellency test
With reference to GB/T
17322.10 1998 " indoor harmacological effect of agriculture chemical registration hygienic insecticide evaluates repellant " method carries out the test of pesticide effectiveness.Test insecticide, test condition, testing time are the same.By qualified (if the mosquito of test is 300 for 3 attacks, have more than 30 the back of the hand attacking volunteer then to show that the back of the hand attack of this volunteer is qualified in 2 min) volunteer's left hand the back of the hand (3 volunteers) expose the skin of 4 cm × 4 cm, remainder coarse cloth wraps up.0.5g sample is taken out in the present invention that 10 g prepare, it is diluted to thick liquid with 2 m1 glycerol, 2 h before the test, takes 2 parts in 0.5 thick liquid and is respectively coated in 2 volunteer's left hand the back of the hand exposure portion respectively for the thick liquid of 0.1g, and left hand the back of the hand of other 1 volunteer is matched group.The back of the hand of volunteer is put in 2 cages being respectively arranged with 300 female adult culexs by 17:00 simultaneously, and every l h observes once, and each observation time is 2min, persistent period 6 h.As long as the test group scribbling thick liquid has 1 mosquito to suck blood i.e. sentences repellent failure.Often before group test, left hand the back of the hand of remaining 1 volunteer as comparison hands and stretches into 2min in cage, if mosquito challenge quantity is that mosquito attack is qualified more than 30 every time.Retest 2 times.If many group tests are carried out simultaneously, the most only need 1 group of matched group.
2 results
2.1 white mice repellency test results
2.1.1 the present invention minimum anophelifuge concentration test result
2.1.1.1 variable concentrations repelling effect of the present invention
The present invention taking 5 concentration respectively carries out repellent test.Going out from the test result analysis of table 1, the content of the present invention just has repellent effect more than 28%, and therefore this content is that the minimum of white mice is protected concentration in 6 h by the present invention completely.
Table 1 present invention is to white mouse variable concentrations repelling effect
2.2 human body repellency test results selections are that the said herbal medicine of 100% (white mice is i.e. attacked the formula that mosquito number is zero) carries out human body repellency test in 6h to white mice protective rate, and the most qualified for the test culex attack of human body repellency test.Test shows, after these formula powder body are made into thick liquid, in 6 h, the number of times of biting testing culex in addition to the present invention of 28% in table 1 is 0.In table 1, the present invention of 28% has 1 mosquito bite at the 5th h, has 2 mosquito bite at the 6th h, then the content of the present invention of 28% in table 1 is risen to 33%, then carry out human body repellent test, without mosquito bite in 6 h.
2.3 Chinese medicines of the present invention press down mattress effect test as can be known from the results of Table 1, even if the content of the present invention is only 2%, it may have certain fungistatic effect, ensure that the present invention has certain bacteria resistance function in theory.Select the Chinese medicine formula powder body in human body repellency test with human body repellent effect to carry out fungistatic effect test, the results are shown in Table 2.
Table 2 fungistatic effect of the present invention
| Concentration of the present invention | Inhibition zone I (mm) | Inhibition zone II (mm) |
| Containing the present invention 33% | 23-24 | 25-27 |
| Containing the present invention 28% | 25-26 | 24-26 |
| Containing the present invention 23% | 26-27 | 25-26 |
| Containing the present invention 18% | 24-25 | 27-29 |
| Containing the present invention 13% | 22-24 | 25-26 |
| Containing the present invention 8% | 24-25 | 25-27 |
Although the detailed description of the invention to the present invention gives detailed description and explanation above; but it should be noted that; we can carry out various equivalence according to the conception of the present invention to above-mentioned embodiment and change and amendment; function produced by it still without departing from description contained spiritual time, all should be within protection scope of the present invention.
Claims (8)
1. a safety and environmental protection mosquito incense liquid, it is characterized in that, described safety and environmental protection mosquito incense liquid includes the crude drug of following parts by weight: Folium Artemisiae Argyi 5～12 parts, Flos Bauhiniae Variegatae 6-16 part, Herba Menthae 10～20 parts, Herba Cymbopogonis 5～15 parts, Cladonia alpestris (L.) Rabenh. 8～22 points, Herba Eupatorii 9～16 parts, Folium Perillae 5～18 parts, Rhizoma Acori Graminei 6～15 parts, Herba Hedyotidis Diffusae 2～8 parts, Cortex Phellodendri 2～10 parts, Radix Saposhnikoviae 10～20 parts, Folium Perillae Frutescentis 3～9 parts, Radix Semiaquilegiae 10～16 parts, Herba Spilanthis Acmellae 5～18 parts, Fructus Litseae pungentis 10～20 parts, Radix Arnebiae (Radix Lithospermi) 10～20 parts, Herba Moslae 10～20 parts, Herba speranskiae tuberculatae 10～20 parts, fevervine 2～15 parts, Flos Rhododendri Arborei 5～15 parts.
Safety and environmental protection mosquito incense liquid the most according to claim 1, it is characterized in that, described safety and environmental protection mosquito incense liquid also includes the crude drug of following parts by weight: Folium Artemisiae Argyi 8～12 parts, Flos Bauhiniae Variegatae 8～12 parts, Herba Menthae 10～15 parts, Herba Cymbopogonis 8～15 parts, Cladonia alpestris (L.) Rabenh. 10～16 points, Herba Eupatorii 10～15 parts, Folium Perillae 8～12 parts, Rhizoma Acori Graminei 8～15 parts, Herba Hedyotidis Diffusae 2～8 parts, Cortex Phellodendri 4～9 parts, Radix Saposhnikoviae 12～20 parts, Folium Perillae Frutescentis 5～9 parts, Radix Semiaquilegiae 12～16 parts, Herba Spilanthis Acmellae 5～18 parts, Fructus Litseae pungentis 10～20 parts, Radix Arnebiae (Radix Lithospermi) 15～20 parts, Herba Moslae 12～20 parts, Herba speranskiae tuberculatae 12～16 parts, fevervine 5～10 parts, Flos Rhododendri Arborei 5～15 parts.
3. according to safety and environmental protection mosquito incense liquid described in claim 1, it is characterized in that, described safety and environmental protection mosquito incense liquid also includes the crude drug of following parts by weight: Folium Artemisiae Argyi 10 parts, Flos Bauhiniae Variegatae 9 parts, Herba Menthae 12 parts, Herba Cymbopogonis 9 parts, Cladonia alpestris (L.) Rabenh. 15 points, Herba Eupatorii 12 parts, Folium Perillae 10 parts, Rhizoma Acori Graminei 9 parts, Herba Hedyotidis Diffusae 5 parts, Cortex Phellodendri 8 parts, Radix Saposhnikoviae 16 parts, Folium Perillae Frutescentis 8 parts, Radix Semiaquilegiae 15 parts, Herba Spilanthis Acmellae 6 parts, Fructus Litseae pungentis 16 parts, Radix Arnebiae (Radix Lithospermi) 18 parts, Herba Moslae 13 parts, Herba speranskiae tuberculatae 15 parts, fevervine 6 parts, Flos Rhododendri Arborei 10 parts.
4. the preparation method of safety and environmental protection mosquito incense liquid as according to any one of claims 1 to 3, it is characterised in that the preparation method of described safety and environmental protection mosquito incense liquid comprises the following steps:
A. take Flos Bauhiniae Variegatae, Herba Cymbopogonis, Herba Menthae, Rhizoma Acori Graminei, Herba Moslae and the fevervine way of distillation and be vaporized into crystallization, pulverize dusting cover stand-by, as component one；
B. the extraction of surplus stock medicinal alcohol is taken, as component two；
C. by stripped for ethanol medicinal residues soak by water 2 times, concentrated extracting solution is merged, as component three；
D. component one, component two and component three are merged and be condensed into concentrated solution, be divided into bottle packaging.
The preparation method of safety and environmental protection mosquito incense liquid the most according to claim 4, it is characterized in that, in described step a, first crude drug Flos Bauhiniae Variegatae, Herba Cymbopogonis, Herba Menthae, Rhizoma Acori Graminei, Herba Moslae and fevervine steam method are distilled, obtain crystal, then pulverize, cross 100-120 mesh sieve, standby as component one.
The preparation method of safety and environmental protection mosquito incense liquid the most according to claim 4, it is characterized in that, in described step b, remaining crude drug is shredded, is soaked and be placed in lid stainless steel cask, add 70% ethanol, quality is coarse grained 0.8-1 times, stir, moistening airtight placement more than 1 hour, make fully to expand；By bottom percolator filter plate gauze bag parcel pave after again the drug sample after moistening expansion is mixed pine do dissipate, then powder is contained with rustless steel spoon, load percolator uniformly, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitably pressurization, medicated powder loads 2/3 eminence that must not exceed percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, is then slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, controlling percolation speed and be generally 1000g medical material outflow per minute 2～3ml, filtrate puts into liquid container, and pours ethanol during emptying into liquid container；Being merged by percolate and stand, stand for standby use, as component two.
The preparation method of safety and environmental protection mosquito incense liquid the most according to claim 4, it is characterised in that in described step c, above-mentioned stripped raw material residue is put in 10 times amount water, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, united extraction liquid, 100-120 mesh filters, then the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming, the filtrate of 1.05 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, as component three.
The preparation method of safety and environmental protection mosquito incense liquid the most according to claim 4, in described step d, first component two is merged with component three, put in economic benefits and social benefits vacuum concentrator and mix, first concentrating the filtrate to relative density when 80 DEG C is the concentrated solution of 1.32, sets to 0～5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr that cold preservation liquid is added 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml concentrated solution Han 0.1g, add component one stir sub-bottle loading.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610191748.3A CN105831181A (en) | 2016-03-30 | 2016-03-30 | Safe environment-friendly mosquito-repellent incense solution and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610191748.3A CN105831181A (en) | 2016-03-30 | 2016-03-30 | Safe environment-friendly mosquito-repellent incense solution and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105831181A true CN105831181A (en) | 2016-08-10 |
Family
ID=56584741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610191748.3A Pending CN105831181A (en) | 2016-03-30 | 2016-03-30 | Safe environment-friendly mosquito-repellent incense solution and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105831181A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102939998A (en) * | 2012-11-28 | 2013-02-27 | 滨州职业学院 | Mosquito repellent liquid and preparation method thereof |
| CN103070817A (en) * | 2012-12-19 | 2013-05-01 | 青岛蔚蓝生物集团有限公司 | Mosquito repellent liquid |
-
2016
- 2016-03-30 CN CN201610191748.3A patent/CN105831181A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102939998A (en) * | 2012-11-28 | 2013-02-27 | 滨州职业学院 | Mosquito repellent liquid and preparation method thereof |
| CN103070817A (en) * | 2012-12-19 | 2013-05-01 | 青岛蔚蓝生物集团有限公司 | Mosquito repellent liquid |
Non-Patent Citations (1)
| Title |
|---|
| 付臣臣等: "41种植物精油对淡色库蚊的熏蒸活性", 《昆虫学报》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101804166B (en) | Traditional Chinese medicine composition for treating dermatitis and eczema of infants | |
| CN103041173B (en) | Traditional Chinese medicine external preparation for curing dermatitis and eczema and preparing method thereof | |
| CN104286486B (en) | For functional feed treating duck viral hepatitis and preparation method thereof | |
| CN105724462A (en) | Electric mosquito-repellent incense liquid and preparation method | |
| CN106818922A (en) | A kind of mosquito repellent composition and preparation method thereof, sachet and application | |
| CN102755446A (en) | Tea oil burn cream and preparation method thereof | |
| CN105853263A (en) | Traditional Chinese medicinal mosquito repelling liquid and preparation method thereof | |
| CN104398934A (en) | Traditional Chinese medicine combination for treating cutaneous pruritus and preparation method thereof | |
| CN102370910A (en) | Wart treating medicament and preparation method thereof | |
| CN105395948A (en) | traditional Chinese medicine additive for eel and preparation method thereof | |
| CN104857290A (en) | Traditional Chinese medicine disinfection ointment for treating scalds and burns and preparation method thereof | |
| CN105056159A (en) | Medicine for treating parasitic diseases of pigs and preparation method thereof | |
| CN103720841A (en) | Chinese medicinal preparation for treating chronic suppurative otitis media and preparation method thereof | |
| CN105148308A (en) | Novel bacteria-disinfecting, residue-removing and environment-friendly material | |
| CN103721138A (en) | External traditional Chinese medicinal preparation for treating acne rosacea and preparation method thereof | |
| CN104258252A (en) | Pharmaceutical composition for treating duck virus hepatitis and preparation method thereof | |
| CN106377604A (en) | Antibacterial inflammation diminishing and itching relieving traditional Chinese medicine ointment and preparation method thereof | |
| CN113855649A (en) | Medicine of Lingxian Tougu bone pain-relieving paste mainly containing clematis root and speranskia herb and preparation method thereof | |
| CN105796468A (en) | Preparation method of Vanilla peanigoeia Ancer toilet water | |
| CN105831181A (en) | Safe environment-friendly mosquito-repellent incense solution and preparation method thereof | |
| CN104922449A (en) | Traditional Chinese medicine disinfection solution and preparation method thereof | |
| CN101879028B (en) | Method for making novel medicine fragrance health-care pillow | |
| CN103721141A (en) | External preparation for treating chronic eczema of scrotum and preparation method thereof | |
| CN103830633B (en) | A kind of algae health preserving powder for dipping feet | |
| CN103055038B (en) | Pure Chinese medicinal composition for treating bee chalkbrood disease and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160810 |
|
| WD01 | Invention patent application deemed withdrawn after publication |