CN103623457A - Special-shaped hydrogel functional dressing and preparation method thereof - Google Patents
Special-shaped hydrogel functional dressing and preparation method thereof Download PDFInfo
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- CN103623457A CN103623457A CN201310664339.7A CN201310664339A CN103623457A CN 103623457 A CN103623457 A CN 103623457A CN 201310664339 A CN201310664339 A CN 201310664339A CN 103623457 A CN103623457 A CN 103623457A
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Abstract
The invention relates to special-shaped hydrogel functional dressing and a preparation method thereof. The special-shaped hydrogel functional dressing comprises a hydrogel functional dressing body, wherein the hydrogel functional dressing body is sphere or hemisphere-shaped; the surface of the hydrogel functional dressing body is smooth or a bulge is formed on the surface of the hydrogel functional dressing body. The preparation method comprises the following steps: injecting hydrophilic high-molecular polymer aqueous solution with the mass content percentage being 5 to 7 percent into a mold, and preparing the special-shaped hydrogel functional dressing through a physical crosslinking method or a chemical crosslinking method. The special-shaped hydrogel functional dressing has good biocompatibility, and is non-irritative and non-sensitized to skin; the dressing has good transparency, and the condition of wound healing can be directly observed through the dressing; the dressing can provide wet environment for promoting wound healing, and does not adhere the wound, reduces scar hyperplasia and accelerates wound healing.
Description
Technical field
The present invention relates to a kind of special-shaped hydrogel functional dressings and preparation method thereof.
Background technology
In all kinds of burn and scald, the injured proportion in hand position is very large, because muscle and the nervous tissue of hand are the most accurate, the cicatrix that burn and scald causes and cicatricial contracture, the lighter can affect hand form, causes ugly outward appearance, and severe one can make its function completely lose.The wound of hand burn and scald is also the process that wound surface forms cambium and epidermal growth, and in clinical proof wound, rehabilitation auxiliary treatment timely can the most effectively alleviate cicatrix, tissue adhesion and muscle contracture.At present, domestic not being reported is applicable to the wound surface nursing of hand burn and scald and wound surface care product that can practical function rehabilitation auxiliary treatment.The nursing of hand empyrosis wound surface, is conventionally used binder or other sheet material dressing to wrap up, and in wound, occurs muscle contracture and joint stiffness for fear of hand burn and scald, conventionally need to be by the auxiliary fixedly hand-type of other apparatuses.For hand function treatment and rehabilitation, Main Means is for massage and carry out functional exercise by equipment.Because massage can only be at wound healing to a certain degree carrying out afterwards, so passive massage treatment can not be carried out functional exercise in time.Present stage, the rehabilitation material for hand was mainly elastic glove, bouncing ball and other similar products, and this type of equipment is mainly plastics or silica gel material, due to its dry tack free, if be directly used in the hand that wound surface does not heal, can cause hand wound and equipment to stick together, to wound surface, cause secondary to destroy, therefore can only use after completely for skin healing, and cannot to hand, carry out functional rehabilitation auxiliary treatment in time.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of wound surface nursing of hand burn and scald and special-shaped hydrogel functional dressings of functional rehabilitation auxiliary treatment and preparation method thereof of can be applicable to.
The technical scheme that the present invention solves the problems of the technologies described above is as follows: a kind of special-shaped hydrogel functional dressings, comprise hydrogel functional dressings body, described hydrogel functional dressings body be shaped as spheroid or hemisphere, and its smooth surface or its surface are provided with projection; Wherein,
The diameter of described hydrogel functional dressings body is 50～250mm;
The quantity of described projection is 5～100, and is evenly distributed in the surface of described hydrogel functional dressings body.
The invention has the beneficial effects as follows: the material of special-shaped hydrogel functional dressings of the present invention is medical aquogel, there is good biocompatibility, non-stimulated to skin, without sensitization; There is good transparency, can directly observe wound healing situation by dressing; The moist environment of wound healing can be provided, adhesion wound surface, alleviate scar hyperplasia, accelerate wound healing; Mechanical strength is moderate, can be fixed sufferer hands shape, avoid hand tissue adhesion, by patient's hand, it is grasped, realize hand function rehabilitation auxiliary treatment, stiff and the muscle contracture of prevention hand joint, realizes wound healing and functional rehabilitation and carries out simultaneously, significantly improves the therapeutic effect of hand burn and scald.
On the basis of technique scheme, the present invention can also do following improvement.
Further, described projection is that diameter is that hemisphere or the diameter of 1～10mm is 1～10mm, the cylinder that height is 1～10mm; Also can be by grasping dressing, to keep other shapes of burn and scald hand function position.
Further, the hydrophilic high molecular polymer aqueous solution that described special-shaped hydrogel functional dressings is 5%～70% by quality percentage composition is made.
Further, the solute in described hydrophilic high molecular polymer aqueous solution is natural hydrophilic high molecular polymer and/or synthesis hydrophilic high molecular polymer.
Further, described natural hydrophilic high molecular polymer is any one or the two or more mixture in starch, cellulose, methylcellulose, carboxymethyl cellulose, hydroxypropyl cellulose, agar, carrageenin, arabic gum, pectin, xanthan gum, carrageenan, alginate, hyaluronic acid, gelatin, osseocolla, polyglutamic acid, polylysine, fibrin, elastin laminin or keratin.
Further, described synthetic hydrophilic polymer polymer is any one or the two or more mixture in polyacrylamide, polyacrylic acid, polyacrylate, polyvinylpyridine, polyvinylpyrrolidone, polyvinyl alcohol, polymaleic anhydride, polyquaternium, Polyethylene Glycol, polyethylene glycol oxide or polyvinylpyrrolidone.
Another technical scheme that the present invention solves the problems of the technologies described above is as follows: a kind of preparation method of special-shaped hydrogel functional dressings, preparation method is as follows: the hydrophilic high molecular polymer aqueous solution that is 5%～70% by quality percentage composition injects mould, by physical crosslinking method and/or Chemical Crosslinking Methods, makes described special-shaped hydrogel functional dressings.
Further, described physical crosslinking method be freezing processing method, freeze partial dehydration method, repeatedly freeze fusion method and freeze in the crystallizing process under low temperature any one or two or more combine use.
Further, described Chemical Crosslinking Methods be that thermal polymerization is crosslinked, initiator cause crosslinked, photopolymerization is crosslinked, cross-linking radiation, plasma-initiated polymerization is crosslinked and electrolysis polymerization in crosslinked any one or two or more combine use.
Accompanying drawing explanation
Fig. 1 is that the projection in the present invention's abnormity hydrogel functional dressings is hemispheroidal structural representation;
Fig. 2 is that the projection in the present invention's abnormity hydrogel functional dressings is cylindrical structural representation;
In accompanying drawing, the list of parts of each label representative is as follows:
1, projection, 2, hydrogel functional dressings body.
The specific embodiment
Below in conjunction with accompanying drawing, principle of the present invention and feature are described, example, only for explaining the present invention, is not intended to limit scope of the present invention.
A special-shaped hydrogel functional dressings, comprises hydrogel functional dressings body 2, described hydrogel functional dressings body 2 be shaped as spheroid or hemisphere, and its smooth surface or its surface are provided with projection 1; Wherein,
The diameter of described hydrogel functional dressings body 2 is 50～250mm;
Described protruding 1 quantity is 5～100, and is evenly distributed in the surface of described hydrogel functional dressings body 2.
Described protruding 1 comprises that diameter is that hemisphere (as shown in Figure 1) or the diameter of 1～10mm is 1～10mm, the cylinder that height is 1～10mm (as shown in Figure 2).
The hydrophilic high molecular polymer aqueous solution that described special-shaped hydrogel functional dressings is 5%～70% by quality percentage composition is made.
Solute in described hydrophilic high molecular polymer aqueous solution is natural hydrophilic high molecular polymer and/or synthesis hydrophilic high molecular polymer.
Described natural hydrophilic high molecular polymer is any one or the two or more mixture in starch, cellulose, methylcellulose, carboxymethyl cellulose, hydroxypropyl cellulose, agar, carrageenin, arabic gum, pectin, xanthan gum, carrageenan, alginate, hyaluronic acid, gelatin, osseocolla, polyglutamic acid, polylysine, fibrin, elastin laminin or keratin.
Described synthetic hydrophilic polymer polymer is any one or the two or more mixture in polyacrylamide, polyacrylic acid, polyacrylate, polyvinylpyridine, polyvinylpyrrolidone, polyvinyl alcohol, polymaleic anhydride, polyquaternium, Polyethylene Glycol, polyethylene glycol oxide or polyvinylpyrrolidone.
The preparation method of above-mentioned special-shaped hydrogel functional dressings is as follows: the hydrophilic high molecular polymer aqueous solution that is 5%～70% by quality percentage composition injects mould, by physical crosslinking method and/or Chemical Crosslinking Methods, makes described special-shaped hydrogel functional dressings.
Described physical crosslinking method is freezing processing method, freeze partial dehydration method, repeatedly freeze fusion method and freeze in the crystallizing process under low temperature any one or two or more combine use.
Described Chemical Crosslinking Methods is that thermal polymerization is crosslinked, initiator cause crosslinked, photopolymerization is crosslinked, cross-linking radiation, plasma-initiated polymerization is crosslinked and electrolysis polymerization in crosslinked any one or two or more combine use.
Below by several specific embodiments so that the present invention is specifically described.
Embodiment 1
Press the polyvinyl alcohol (PVA) of mass fraction 10%, it is 5cm that 2% aqueous gelatin solution injects diameter, and in ganoid hemisphere mould, Co 60 radioactive source carries out radiation process processing, radiation dose 15kgy, obtains described for hand burn and scald abnormity hydrogel functional dressings after radiation.
Embodiment 2
Press the Polyethylene Glycol (PEG) of mass fraction 10%, it is 5cm that 5% polyvinylpyrrolidone (PVP) aqueous solution injects diameter, in the spheroid mould of 15 diameter 2mm hemisphere projections of surface uniform branch, after being fixed, put into refrigerator and be refrigerated to-18 ℃, cooling time 20h, freezingly completely will make it to rise in its holding chamber after room temperature, places with cobalt source and carries out radiation process processing, radiation dose 15kgy, obtains described for hand burn and scald abnormity hydrogel functional dressings after radiation.
Embodiment 3
Press the polyvinyl alcohol (PVA) of mass fraction 15%, it is 7cm that 35% polyglutamic acid aqueous solution injects diameter, in the hemisphere mould of 30 diameter 5mm spheroid projections of surface uniform branch, after being fixed, put into refrigerator and be refrigerated to-18 ℃, cooling time 20h, circulates 2 times, freezingly completely will in its holding chamber, make it to rise to after room temperature, place with cobalt source and carry out radiation process processing, radiation dose 15kgy, obtains described for hand burn and scald abnormity hydrogel functional dressings after radiation.
Embodiment 4
Press the polyvinyl alcohol (PVA) of mass fraction 5%, it is 5cm that 15% sodium alginate aqueous solution is injected diameter, in the protruding spheroid mould that surface distributed can embed the five fingers, after being fixed, put into refrigerator and be refrigerated to-18 ℃, cooling time 20h, freezing complete by making it to rise in its holding chamber after room temperature, by electron accelerator, carry out radiation sterilization processing, radiation dose 20kgy, obtains described for hand burn and scald abnormity hydrogel functional dressings.
Embodiment 5
Press the polylysine of mass fraction 5%, it is 10cm that 5% carboxymethyl cellulose aqueous solution injects diameter, in the hemisphere mould of 10 diameter 10mm spheroid projections of surface uniform branch, after being fixed, put into refrigerator and be refrigerated to-18 ℃, cooling time 20h, freezing complete by making it to rise in its holding chamber after room temperature, by electron accelerator, carry out radiation sterilization processing, radiation dose 20kgy, obtains described for hand burn and scald abnormity hydrogel functional dressings.
Embodiment 6
Press the sodium polyacrylate of mass fraction 15%, it is 10cm that 5% aqueous gelatin solution injects diameter, in the hemisphere mould of 10 diameter 5mm spheroid projections of surface uniform branch, 48h is preserved in sealing, after chemical reaction is complete, by electron accelerator, carry out radiation sterilization processing, radiation dose 20kgy, obtains described for hand burn and scald abnormity hydrogel functional dressings.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (9)
1. a special-shaped hydrogel functional dressings, is characterized in that, comprises hydrogel functional dressings body, described hydrogel functional dressings body be shaped as spheroid or hemisphere, and its smooth surface or its surface are provided with projection; Wherein,
The diameter of described hydrogel functional dressings body is 50～250mm;
The quantity of described projection is 5～100, and is evenly distributed in the surface of described hydrogel functional dressings body.
2. special-shaped hydrogel functional dressings according to claim 1, is characterized in that: described projection comprises that diameter is that hemisphere or the diameter of 1～10mm is 1～10mm, the cylinder that height is 1～10mm.
3. special-shaped hydrogel functional dressings according to claim 1 and 2, is characterized in that: the hydrophilic high molecular polymer aqueous solution that described special-shaped hydrogel functional dressings is 5%～70% by quality percentage composition is made.
4. special-shaped hydrogel functional dressings according to claim 3, is characterized in that: the solute in described hydrophilic high molecular polymer aqueous solution is natural hydrophilic high molecular polymer and/or synthesis hydrophilic high molecular polymer.
5. special-shaped hydrogel functional dressings according to claim 4, is characterized in that: described natural hydrophilic high molecular polymer is any one or the two or more mixture in starch, cellulose, methylcellulose, carboxymethyl cellulose, hydroxypropyl cellulose, agar, carrageenin, arabic gum, pectin, xanthan gum, carrageenan, alginate, hyaluronic acid, gelatin, osseocolla, polyglutamic acid, polylysine, fibrin, elastin laminin or keratin.
6. special-shaped hydrogel functional dressings according to claim 4, is characterized in that: described synthetic hydrophilic polymer polymer is any one or the two or more mixture in polyacrylamide, polyacrylic acid, polyacrylate, polyvinylpyridine, polyvinylpyrrolidone, polyvinyl alcohol, polymaleic anhydride, polyquaternium, Polyethylene Glycol, polyethylene glycol oxide or polyvinylpyrrolidone.
7. the preparation method of a special-shaped hydrogel functional dressings, it is characterized in that, preparation method is as follows: the hydrophilic high molecular polymer aqueous solution that is 5%～70% by quality percentage composition injects mould, by physical crosslinking method and/or Chemical Crosslinking Methods, makes described special-shaped hydrogel functional dressings.
8. the preparation method of special-shaped hydrogel functional dressings according to claim 7, it is characterized in that, described physical crosslinking method is freezing processing method, freeze partial dehydration method, repeatedly freeze fusion method and freeze in the crystallizing process under low temperature any one or two or more combine use.
9. the preparation method of special-shaped hydrogel functional dressings according to claim 7, it is characterized in that, described Chemical Crosslinking Methods is that thermal polymerization is crosslinked, initiator cause crosslinked, photopolymerization is crosslinked, cross-linking radiation, plasma-initiated polymerization is crosslinked and electrolysis polymerization in crosslinked any one or two or more combine use.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104892864A (en) * | 2015-06-03 | 2015-09-09 | 西北师范大学 | Preparation of keratin-sodium alginate composite microporous gel and application of gel as drug carrier |
| CN105879102A (en) * | 2016-05-31 | 2016-08-24 | 西北师范大学 | Feather keratin-grafted alginic acid sponge dressing and preparation method thereof |
| CN106267316A (en) * | 2016-08-18 | 2017-01-04 | 南京轩凯生物科技有限公司 | A kind of anti-dehydration Gekko Swinhonis hydrogel application and preparation method thereof |
| CN107693842A (en) * | 2017-12-05 | 2018-02-16 | 湖北美尔丽生物科技有限公司 | A kind of medical resistance to hydrogel and preparation method thereof |
| CN109045339A (en) * | 2018-08-29 | 2018-12-21 | 郑州工程技术学院 | A kind of medical compound antiseptic dressing and preparation method thereof |
| CN109251451A (en) * | 2018-08-30 | 2019-01-22 | 太原理工大学 | A kind of preparation method of pH responsive type xanthan gum/polyvinyl alcohol hydrogel |
| CN111166563A (en) * | 2020-02-24 | 2020-05-19 | 上海白衣缘生物工程有限公司 | Medical isolation pad for preventing skin indentation pressure sores |
| CN113576757A (en) * | 2021-09-03 | 2021-11-02 | 军事科学院系统工程研究院卫勤保障技术研究所 | Chitosan polymer dressing |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104892864A (en) * | 2015-06-03 | 2015-09-09 | 西北师范大学 | Preparation of keratin-sodium alginate composite microporous gel and application of gel as drug carrier |
| CN105879102A (en) * | 2016-05-31 | 2016-08-24 | 西北师范大学 | Feather keratin-grafted alginic acid sponge dressing and preparation method thereof |
| CN105879102B (en) * | 2016-05-31 | 2019-08-16 | 西北师范大学 | A kind of feather keratin grafting alginic acid sponge dressing and preparation method thereof |
| CN106267316A (en) * | 2016-08-18 | 2017-01-04 | 南京轩凯生物科技有限公司 | A kind of anti-dehydration Gekko Swinhonis hydrogel application and preparation method thereof |
| CN106267316B (en) * | 2016-08-18 | 2019-09-13 | 南京轩凯生物科技有限公司 | Anti- dehydration gecko hydrogel application of one kind and preparation method thereof |
| CN107693842A (en) * | 2017-12-05 | 2018-02-16 | 湖北美尔丽生物科技有限公司 | A kind of medical resistance to hydrogel and preparation method thereof |
| CN109045339A (en) * | 2018-08-29 | 2018-12-21 | 郑州工程技术学院 | A kind of medical compound antiseptic dressing and preparation method thereof |
| CN109045339B (en) * | 2018-08-29 | 2021-06-11 | 郑州工程技术学院 | Medical composite antibacterial dressing and preparation method thereof |
| CN109251451A (en) * | 2018-08-30 | 2019-01-22 | 太原理工大学 | A kind of preparation method of pH responsive type xanthan gum/polyvinyl alcohol hydrogel |
| CN109251451B (en) * | 2018-08-30 | 2021-03-19 | 太原理工大学 | Preparation method of pH-sensitive xanthan gum/polyvinyl alcohol hydrogel |
| CN111166563A (en) * | 2020-02-24 | 2020-05-19 | 上海白衣缘生物工程有限公司 | Medical isolation pad for preventing skin indentation pressure sores |
| CN113576757A (en) * | 2021-09-03 | 2021-11-02 | 军事科学院系统工程研究院卫勤保障技术研究所 | Chitosan polymer dressing |
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