CN103623457B - Special-shaped hydrogel functional dressing and preparation method thereof - Google Patents
Special-shaped hydrogel functional dressing and preparation method thereof Download PDFInfo
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- CN103623457B CN103623457B CN201310664339.7A CN201310664339A CN103623457B CN 103623457 B CN103623457 B CN 103623457B CN 201310664339 A CN201310664339 A CN 201310664339A CN 103623457 B CN103623457 B CN 103623457B
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Abstract
The invention relates to special-shaped hydrogel functional dressing and a preparation method thereof. The special-shaped hydrogel functional dressing comprises a hydrogel functional dressing body, wherein the hydrogel functional dressing body is sphere or hemisphere-shaped; the surface of the hydrogel functional dressing body is smooth or a bulge is formed on the surface of the hydrogel functional dressing body. The preparation method comprises the following steps: injecting hydrophilic high-molecular polymer aqueous solution with the mass content percentage being 5 to 7 percent into a mold, and preparing the special-shaped hydrogel functional dressing through a physical crosslinking method or a chemical crosslinking method. The special-shaped hydrogel functional dressing has good biocompatibility, and is non-irritative and non-sensitized to skin; the dressing has good transparency, and the condition of wound healing can be directly observed through the dressing; the dressing can provide wet environment for promoting wound healing, and does not adhere the wound, reduces scar hyperplasia and accelerates wound healing.
Description
Technical field
The present invention relates to a kind of special-shaped hydrogel functional dressings and preparation method thereof.
Background technology
In all kinds of burn and scald, the injured proportion in hand position is very large, due to the muscle of hand and nervous tissue the most accurate, the cicatrix that burn and scald causes and cicatricial contracture, the lighter can affect hand form, and cause ugly outward appearance, severe one can make its function completely lose.The wound of hand burn and scald is also the process that wound surface forms cambium and epidermal growth, in clinical proof wound rehabilitation auxiliary treatment timely can the most effective lessen scar formation, tissue adhesion and muscle contracture.At present, the domestic wound surface nursing that is applicable to hand burn and scald and can the wound surface care product of practical function rehabilitation auxiliary treatment of not being reported.Hand empyrosis wound surface is nursed, and usually uses binder or other sheet material dressing to wrap up, and in wound, occurs muscle contracture and joint stiffness in order to avoid hand burn and scald, usually needs by the auxiliary fixing hand-type of other apparatuses.For hand function treatment and rehabilitation, Main Means is for massage and carry out functional exercise by equipment.Because massage can only at wound healing to a certain degree carrying out afterwards, so passive massage treatment can not carry out functional exercise in time.Present stage is mainly elastic glove, bouncing ball and other similar products for the rehabilitation material of hand, and this type of equipment is mainly plastics or silica gel material, due to its dry tack free, if be directly used in the hand that wound surface does not heal, hand wound and equipment can be caused to stick together, man-made further destroy is caused to wound surface, therefore can only be used for skin healing and use completely afterwards, and functional rehabilitation auxiliary treatment cannot be carried out to hand in time.
Summary of the invention
Technical problem to be solved by this invention be to provide a kind of can be applicable to hand burn and scald wound surface nursing and the special-shaped hydrogel functional dressings and preparation method thereof of functional rehabilitation auxiliary treatment.
The technical scheme that the present invention solves the problems of the technologies described above is as follows: a kind of special-shaped hydrogel functional dressings, comprise hydrogel functional dressings body, the shape of described hydrogel functional dressings body is spheroid or hemisphere, and its smooth surface or its be provided with projection on the surface; Wherein,
The diameter of described hydrogel functional dressings body is 50 ~ 250mm;
The quantity of described projection is 5 ~ 100, and is evenly distributed in the surface of described hydrogel functional dressings body.
The invention has the beneficial effects as follows: the material of special-shaped hydrogel functional dressings of the present invention is medical aquogel, has good biocompatibility, non-stimulated to skin, without sensitization; There is good transparency, directly observe wound healing situation by dressing; The wet environment of wound healing can be provided, adhesion wound surface, lessen scar formation hypertrophy, acceleration wound healing; Mechanical strength is moderate, can be fixed sufferer hands shape, avoid hand tissue adhesion, by patient hand, it is grasped, realize hand function rehabilitation auxiliary treatment, stiff and the muscle contracture of prevention hand joint, realizes wound healing and functional rehabilitation carries out simultaneously, significantly improves the therapeutic effect of hand burn and scald.
On the basis of technique scheme, the present invention can also do following improvement.
Further, hemisphere or the diameter of described projection to be diameter be 1 ~ 10mm are 1 ~ 10mm, and height is the cylinder of 1 ~ 10mm; Also can be other shapes keeping burn and scald hand function position by grasping dressing.
Further, the hydrophilic high molecular polymer aqueous solution that described special-shaped hydrogel functional dressings is 5% ~ 70% by mass percentage is made.
Further, the solute in described hydrophilic high molecular polymer aqueous solution is natural hydrophilic high molecular polymer and/or synthesis hydrophilic high molecular polymer.
Further, described natural hydrophilic high molecular polymer is any one or the two or more mixture in starch, cellulose, methylcellulose, carboxymethyl cellulose, hydroxypropyl cellulose, agar, carrageenin, arabic gum, pectin, xanthan gum, carrageenan, alginate, hyaluronic acid, gelatin, osseocolla, polyglutamic acid, polylysine, fibrin, elastin laminin or keratin.
Further, described synthetic hydrophilic polymer polymer is any one or the two or more mixture in polyacrylamide, polyacrylic acid, polyacrylate, polyvinylpyridine, polyvinylpyrrolidone, polyvinyl alcohol, polymaleic anhydride, polyquaternium, Polyethylene Glycol, polyethylene glycol oxide or polyvinylpyrrolidone.
Another technical scheme that the present invention solves the problems of the technologies described above is as follows: a kind of preparation method of special-shaped hydrogel functional dressings, preparation method is as follows: be the hydrophilic high molecular polymer aqueous solution injection mould of 5% ~ 70% by mass percentage, make described special-shaped hydrogel functional dressings by Physical cross linking methods and/or Chemical Crosslinking Methods.
Further, described Physical cross linking methods is freezing processing method, frozen fraction evaporation, repeatedly freezes fusion method and freeze any one or the two or more conbined usage in the crystallizing process under low temperature.
Further, described Chemical Crosslinking Methods be that thermal polymerization is cross-linked, initiator cause crosslinked, photopolymerization is cross-linked, cross-linking radiation, plasma-initiated polymerization are cross-linked and electrolysis polymerization be cross-linked in any one or two or more conbined usage.
Accompanying drawing explanation
Fig. 1 is the projection in the present invention's abnormity hydrogel functional dressings is hemispheroidal structural representation;
Fig. 2 is the projection in the present invention's abnormity hydrogel functional dressings is cylindrical structural representation;
In accompanying drawing, the list of parts representated by each label is as follows:
1, protruding, 2, hydrogel functional dressings body.
Detailed description of the invention
Be described principle of the present invention and feature below in conjunction with accompanying drawing, example, only for explaining the present invention, is not intended to limit scope of the present invention.
A kind of special-shaped hydrogel functional dressings, comprise hydrogel functional dressings body 2, the shape of described hydrogel functional dressings body 2 is spheroid or hemisphere, and its smooth surface or its be provided with protruding 1 on the surface; Wherein,
The diameter of described hydrogel functional dressings body 2 is 50 ~ 250mm;
The described quantity of protruding 1 is 5 ~ 100, and is evenly distributed in the surface of described hydrogel functional dressings body 2.
Described protruding 1 comprises hemisphere (as shown in Figure 1) that diameter is 1 ~ 10mm or diameter is 1 ~ 10mm, and height is the cylinder (as shown in Figure 2) of 1 ~ 10mm.
The hydrophilic high molecular polymer aqueous solution that described special-shaped hydrogel functional dressings is 5% ~ 70% by mass percentage is made.
Solute in described hydrophilic high molecular polymer aqueous solution is natural hydrophilic high molecular polymer and/or synthesis hydrophilic high molecular polymer.
Described natural hydrophilic high molecular polymer is any one or two or more mixture in starch, cellulose, methylcellulose, carboxymethyl cellulose, hydroxypropyl cellulose, agar, carrageenin, arabic gum, pectin, xanthan gum, carrageenan, alginate, hyaluronic acid, gelatin, osseocolla, polyglutamic acid, polylysine, fibrin, elastin laminin or keratin.
Described synthetic hydrophilic polymer polymer is any one or two or more mixture in polyacrylamide, polyacrylic acid, polyacrylate, polyvinylpyridine, polyvinylpyrrolidone, polyvinyl alcohol, polymaleic anhydride, polyquaternium, Polyethylene Glycol, polyethylene glycol oxide or polyvinylpyrrolidone.
The preparation method of above-mentioned special-shaped hydrogel functional dressings is as follows: be the hydrophilic high molecular polymer aqueous solution injection mould of 5% ~ 70% by mass percentage, make described special-shaped hydrogel functional dressings by Physical cross linking methods and/or Chemical Crosslinking Methods.
Described Physical cross linking methods is freezing processing method, frozen fraction evaporation, repeatedly freeze fusion method and freeze any one or the two or more conbined usage in the crystallizing process under low temperature.
Described Chemical Crosslinking Methods is that thermal polymerization is cross-linked, initiator cause crosslinked, photopolymerization is cross-linked, cross-linking radiation, plasma-initiated polymerization are cross-linked and electrolysis polymerization be cross-linked in any one or two or more conbined usage.
Below by way of several specific embodiment to be specifically described the present invention.
Embodiment 1
By the polyvinyl alcohol (PVA) of mass fraction 10%, it is 5cm that the aqueous gelatin solution of 2% injects diameter, and in ganoid hemisphere mould, Co 60 radioactive source carries out radiation process process, radiation dose 15kgy, obtains described for hand burn and scald abnormity hydrogel functional dressings after radiation.
Embodiment 2
By the Polyethylene Glycol (PEG) of mass fraction 10%, it is 5cm that polyvinylpyrrolidone (PVP) aqueous solution of 5% injects diameter, in the spheroid mould of surface uniform branch 15 diameter 2mm hemisphere projections, put into refrigerator after being fixed and be refrigerated to-18 DEG C, cooling time 20h, freezing complete by after making it to rise to room temperature in its holding chamber, place and carry out radiation process process with cobalt source, radiation dose 15kgy, obtains described for hand burn and scald abnormity hydrogel functional dressings after radiation.
Embodiment 3
By the polyvinyl alcohol (PVA) of mass fraction 15%, it is 7cm that the polyglutamic acid aqueous solution of 35% injects diameter, in the hemisphere mould of surface uniform branch 30 diameter 5mm spheroid projections, put into refrigerator after being fixed and be refrigerated to-18 DEG C, cooling time 20h, circulate 2 times, freezing complete by after making it to rise to room temperature in its holding chamber, place and carry out radiation process process, radiation dose 15kgy with cobalt source, obtain described for hand burn and scald abnormity hydrogel functional dressings after radiation.
Embodiment 4
By the polyvinyl alcohol (PVA) of mass fraction 5%, it is 5cm that the sodium alginate aqueous solution of 15% injects diameter, in the spheroid mould of the projection that the five fingers can embed by surface distributed, put into refrigerator after being fixed and be refrigerated to-18 DEG C, cooling time 20h, freezing complete by after making it to rise to room temperature in its holding chamber, carry out radiation sterilization process by electron accelerator, radiation dose 20kgy, obtains described for hand burn and scald abnormity hydrogel functional dressings.
Embodiment 5
By the polylysine of mass fraction 5%, it is 10cm that the carboxymethyl cellulose aqueous solution of 5% injects diameter, in the hemisphere mould of surface uniform branch 10 diameter 10mm spheroid projections, put into refrigerator after being fixed and be refrigerated to-18 DEG C, cooling time 20h, freezing complete by after making it to rise to room temperature in its holding chamber, carry out radiation sterilization process by electron accelerator, radiation dose 20kgy, obtains described for hand burn and scald abnormity hydrogel functional dressings.
Embodiment 6
By the sodium polyacrylate of mass fraction 15%, it is 10cm that the aqueous gelatin solution of 5% injects diameter, in the hemisphere mould of surface uniform branch 10 diameter 5mm spheroid projections, 48h is preserved in sealing, after chemical reaction is complete, carry out radiation sterilization process by electron accelerator, radiation dose 20kgy, obtain described for hand burn and scald abnormity hydrogel functional dressings.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (9)
1. a special-shaped hydrogel functional dressings, is characterized in that, comprises hydrogel functional dressings body, and the shape of described hydrogel functional dressings body is spheroid or hemisphere, and its smooth surface or its be provided with projection on the surface; Wherein,
The diameter of described hydrogel functional dressings body is 50 ~ 250mm;
The quantity of described projection is 5 ~ 100, and is evenly distributed in the surface of described hydrogel functional dressings body.
2. special-shaped hydrogel functional dressings according to claim 1, is characterized in that: described projection comprises hemisphere that diameter is 1 ~ 10mm or diameter is 1 ~ 10mm, and height is the cylinder of 1 ~ 10mm.
3. special-shaped hydrogel functional dressings according to claim 1 and 2, is characterized in that: the hydrophilic high molecular polymer aqueous solution that described special-shaped hydrogel functional dressings is 5% ~ 70% by mass percentage is made.
4. special-shaped hydrogel functional dressings according to claim 3, is characterized in that: the solute in described hydrophilic high molecular polymer aqueous solution is natural hydrophilic high molecular polymer and/or synthesis hydrophilic high molecular polymer.
5. special-shaped hydrogel functional dressings according to claim 4, is characterized in that: described natural hydrophilic high molecular polymer is any one or two or more mixture in starch, methylcellulose, carboxymethyl cellulose, hydroxypropyl cellulose, agar, carrageenin, arabic gum, pectin, xanthan gum, carrageenan, alginate, hyaluronic acid, gelatin, osseocolla, polyglutamic acid, polylysine, fibrin, elastin laminin or keratin.
6. special-shaped hydrogel functional dressings according to claim 4, is characterized in that: described synthetic hydrophilic polymer polymer is any one or two or more mixture in polyacrylamide, polyacrylic acid, polyacrylate, polyvinylpyridine, polyvinyl alcohol, polymaleic anhydride, polyquaternium, Polyethylene Glycol, polyethylene glycol oxide or polyvinylpyrrolidone.
7. the preparation method of the special-shaped hydrogel functional dressings according to any one of claim 1 to 6, it is characterized in that, preparation method is as follows: be the hydrophilic high molecular polymer aqueous solution injection mould of 5% ~ 70% by mass percentage, make described special-shaped hydrogel functional dressings by Physical cross linking methods and/or Chemical Crosslinking Methods.
8. the preparation method of special-shaped hydrogel functional dressings according to claim 7, it is characterized in that, described Physical cross linking methods is freezing processing method, frozen fraction evaporation, repeatedly freeze fusion method and freeze any one or the two or more conbined usage in the crystallizing process under low temperature.
9. the preparation method of special-shaped hydrogel functional dressings according to claim 7, it is characterized in that, described Chemical Crosslinking Methods is that thermal polymerization is cross-linked, initiator cause crosslinked, photopolymerization is cross-linked, cross-linking radiation, plasma-initiated polymerization are cross-linked and electrolysis polymerization be cross-linked in any one or two or more conbined usage.
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| CN104892864B (en) * | 2015-06-03 | 2017-09-22 | 西北师范大学 | The preparation and the application as pharmaceutical carrier of a kind of composite microporous gel of keratin sodium alginate |
| CN105879102B (en) * | 2016-05-31 | 2019-08-16 | 西北师范大学 | A kind of feather keratin grafting alginic acid sponge dressing and preparation method thereof |
| CN106267316B (en) * | 2016-08-18 | 2019-09-13 | 南京轩凯生物科技有限公司 | Anti- dehydration gecko hydrogel application of one kind and preparation method thereof |
| CN107693842B (en) * | 2017-12-05 | 2020-05-05 | 湖北美尔丽生物科技有限公司 | Medical water-resistant gel and preparation method thereof |
| CN109045339B (en) * | 2018-08-29 | 2021-06-11 | 郑州工程技术学院 | Medical composite antibacterial dressing and preparation method thereof |
| CN109251451B (en) * | 2018-08-30 | 2021-03-19 | 太原理工大学 | Preparation method of pH-sensitive xanthan gum/polyvinyl alcohol hydrogel |
| CN111166563A (en) * | 2020-02-24 | 2020-05-19 | 上海白衣缘生物工程有限公司 | Medical isolation pad for preventing skin indentation pressure sores |
| CN113576757A (en) * | 2021-09-03 | 2021-11-02 | 军事科学院系统工程研究院卫勤保障技术研究所 | Chitosan polymer dressing |
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| US20020122771A1 (en) * | 2000-09-23 | 2002-09-05 | Troy Holland | Spray hydrogel wound dressings |
| AU2003243001A1 (en) * | 2002-06-19 | 2004-01-06 | Showa Denko K. K. | Hydrous gel and production process and use of the hydrous gel |
| CN103028136A (en) * | 2012-12-14 | 2013-04-10 | 武汉奥绿新生物科技有限公司 | Hydrocolloid dressing and preparation method thereof |
| CN203736391U (en) * | 2013-12-09 | 2014-07-30 | 长春吉原生物科技有限公司 | Heteromorphic hydrogel functional dressing |
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