CN107693842A - A kind of medical resistance to hydrogel and preparation method thereof - Google Patents
A kind of medical resistance to hydrogel and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
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- C08J2339/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Derivatives of such polymers
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Abstract
The invention discloses a kind of medical resistance to hydrogel and preparation method thereof, its formula is made up of following raw materials：Xanthans, sericin, Aristoflex AVC, citric acid, triethyl citrate, glycerine, deionized water；Its preparation method is first to be added to the water xanthans, sericin and Aristoflex AVC to dissolve to obtain mixed liquor A, mixed liquor A is heated to 55 65 DEG C of lower insulation reactions of dropwise addition citric acid stirring and obtains mixed liquid B within 0.4 0.6 hours, insulation reaction under triethyl citrate stirring is added dropwise in mixed liquid B and obtains mixed liquor C within 0.4 0.6 hours, glycerine is added in mixed liquor C to stir, pH of latex gel is adjusted to 4.5 6.0, deaeration, filling, sterilizing, thus obtaining the product；The medical resistance to hydrogel of the present invention, which is applied to the film formed on skin, has excellent water resistance and performance of keeping humidity, can blocks dust, prevent bacterium, virus, fungi invasion, promote wound healing.
Description
Technical field
The present invention relates to medical product technical field, especially a kind of medical resistance to hydrogel and preparation method thereof.
Background technology
The liquid wound-dressing clinically used at present mainly uses gel-like product, but existing liquid wound applies
Expect three problems below generally existing：
（1）Use organic solvent：In order to improve the film forming of liquid dressing and water resistance, second is added with generally in liquid dressing
Acetoacetic ester, acetone and other organic solvent, this kind of organic solvent volatility is good, but very big to human body skin excitant, and to people
Body has certain injury；
（2）Use crosslinking agent：In order that gel products have more preferable water resistance, gel-like dressing is avoided to meet water-solubleization, solidifying
In glue preparation process, improve the film forming of liquid wound-dressing and water resistance usually using crosslinking agent, friendship the most frequently used at present
It is the raw materials such as glutaraldehyde to join agent, but glutaraldehyde has certain harm to health, limits its extensive use clinically；
（3）Poor water resistance, meet water-solubleization：It is water-fast without using the liquid wound-dressing of organic solvent or glutaraldehyde as crosslinking agent
Property is poor, and running into water will dissolve, so being only used for those body parts for being not easy to adhere to water, so limit it and facing
Widely using on bed.
Therefore, research and develop it is a kind of both there is good water resistance, and without using the medical resistance to hydrogel of excitant chemical raw material,
As urgent problem to be solved in industry.
The content of the invention
The purpose of the present invention generally uses excitant organic solvent or water resistance aiming at current existing medical gel
A kind of difference, it is impossible to the problem of widely using, there is provided medical resistance to hydrogel and preparation method thereof；The medical resistance to hydrogel of the present invention is to wound
Non-stimulated, the water-tolerant of mouth, promote wound healing effect notable.
A kind of medical resistance to hydrogel of the present invention, is made up of the raw material of following weight parts：
Xanthans 0.1-5 sericins 0.1-1
Aristoflex AVC 0.1-1 citric acids 0.01-1
Triethyl citrate 0.01-1 glycerine 3-8
Deionized water 80-98.
A kind of medical resistance to hydrogel of the present invention, its optimization formula are made up of the raw material of following weight parts：
Xanthans 0.1-3 sericins 0.1-0.8
Aristoflex AVC 0.1-0.6 citric acids 0.1-0.5
Triethyl citrate 0.1-0.5 glycerine 4-6
Deionized water 85-95.
A kind of medical resistance to hydrogel of the present invention, it is most preferably formulated is made up of the raw material of following weight parts：
The sericin 0.5 of xanthans 2
The citric acids 0.14 of Aristoflex AVC 0.25
The glycerine 5 of triethyl citrate 0.14
Water 91.65.
The xanthans is dusty raw materials of the purity more than 95% using molecular weight more than 1,000,000；
The sericin be use purity for more than 99% water-soluble silk glue protein powder；
The Aristoflex AVC, Chinese are acrylamide dimethyltaurine ammonium/VP copolymers, be use purity for
More than 92% dusty raw materials；
The citric acid be use mass fraction for 10% aqueous citric acid solution；
The triethyl citrate be use purity for more than 99% food-class liquid raw material；
The glycerine is to use medical pure glycerin.
A kind of preparation method of medical resistance to hydrogel of the present invention, is made up of following step successively：
（1）Xanthans, sericin and Aristoflex AVC are taken by formula rate, sequentially adds in water and dissolves, side edged stirs
Mix, obtain mixed liquor A；
（2）Mixed liquor A is heated to 55-65 DEG C, the citric acid that the mass fraction being slowly added dropwise in mixed liquor A is 10% is water-soluble
Liquid, be added dropwise to complete within 5 minutes, add citric acid quality be mixed liquor A Solute mass sum 1-10%, keeping temperature
At 60 DEG C, and uniform stirring 1-1.5 hours, obtain mixed liquid B；
（3）Triethyl citrate is added in mixed liquid B, add the quality of triethyl citrate for mixed liquor A Solute mass it
The 1-10% of sum, it was added dropwise to complete within 5 minutes, maintains the temperature at 60 DEG C, and uniform stirring 0.4-0.6 hours, obtain mixed liquor C；
（4）Glycerine is added in mixed liquor C to stir, and adds the 3-8% that qualities of glycerin is mixed liquor C mass, it is thick to obtain gel
Body；
（5）The pH to 4.5-6.0 of gel runic, natural cooling are adjusted with the sodium hydroxide solution that mass fraction is 5% under agitation
To room temperature, standing and defoaming is filling, irradiation sterilization, produces.
Film forming agent xanthans used in the present invention, also known as yellow glue, xanthan gum, Xanthan Gum, are through Huang by carbohydrate
Pseudomonas bacillus ferments, caused extracellular microbial polysaccharide.Due to its macromolecular special construction and colloid property, and with a variety of
Function, the stabilizer as a variety of purposes, thickening agent and processing spread auxiliary agent in the industry at present, including make canned and bottled food
Product, bakery food, dairy produce, frozen food, salad flavouring, beverage, brewage, candy, cake pattern be with product etc..At present also
It is not applied in medical resistance to hydrogel product, is based on the following excellent of it from xanthans as film forming agent in the present invention
Performance：
1. suspension and emulsibility
Xanthans has good suspension effect to insoluble solid and oil droplet, and xanthans colloidal sol molecule can form superjunction crossed belt shape
Spiral EVA, form fragility similar glue network structure, so the shape of solid particle, drop and bubble can be supported
State, show very strong stable emulsifying effect and uphang i；
2. good water solubility
Xanthans can quickly dissolve in water, there is good water solubility, can also be dissolved especially in cold water, can save numerous and diverse add
Work process, it is easy to use, xanthans dry powder or delay after being mixed thoroughly with dry powder auxiliary materials such as salt, sugar and promote to add in the water stirred, system
Used into solution；
3. thickening property
Xanthan gum solution has the highly viscous characteristic of low concentration (100 times of the viscosity of 1% aqueous solution equivalent to gelatin), is a kind of
Efficient thickener；
4. pseudoplastic behavior
Xanthan gum solution has high viscosity under static or low shear action, and viscosity is shown as under high shear forces drastically
Decline, but molecular structure is constant, and when shearing force eliminates, then recover the relation of original viscosity, shearing force and viscosity immediately
It is completely plastic, xanthans pseudoplastic behavior is very prominent, and this pseudoplastic behavior is extremely effective to stable suspension, emulsion；
5. pair hot stability
The viscosity of xanthan gum solution will not variation with temperature and change a lot, in general polysaccharide because heating can glue
Degree change, but the aqueous solution of xanthans viscosity between 10-80 DEG C has almost no change, even if the aqueous solution of low concentration is wide
Within the temperature range of still show stable high viscosity, 1% xanthan gum solution (containing 1% potassium chloride) is heated to 120 DEG C of from 25 DEG C
Its viscosity only reduces by 3%；
6. the stability of pair soda acid
Xanthan gum solution is sufficiently stable to soda acid, makes its viscosity unaffected between being 5-10 in PH, is less than 4 in PH and is more than
Viscosity has slight change when 11, and xanthans can also be dissolved in sodium hydroxide solution, and the solution formed with thickening characteristic exists
It is sufficiently stable at room temperature；
7. the stability of pair salt
Xanthan gum solution can be miscible with many salting liquids (sylvite, sodium salt, calcium salt, magnesium salts etc.), and viscosity is unaffected, compared with high salt
Under concentration conditions, or even still keep in saturated salt solution its dissolubility without occurring precipitation and flocculation, its viscosity hardly by
Influence；
8. the stability of pair enzyme digestion reaction
The stable double-spiral structure of xanthans makes it have extremely strong anti-oxidant and resistance to enzymolysis ability, many enzymes such as albumen
The enzymes such as enzyme, amylase, cellulase and hemicellulase can not all make Xanthan gum degradation；
Above-mentioned performance has very great help to the later stability of resistance to hydrogel product, hydrophily is made, carries property of medicine etc..
Film forming agent sericin used in the present invention, it is a kind of silk gum shape protein, is globulin, it is total to account for silk
The 20%~30% of weight, silk gum are made up of I, II, III, IV kind of protein from outside to inside；The predominantly random volume of bulk molecule conformation
Song, spatial configuration of molecules is loose, unordered, exists containing beta structure, but without αhelix；Have on sericin chain many side chains compared with
Long amino acid, such as arginine, lysine, glutamic acid, methionine, tryptophan, tyrosine, and many polar hydrophilic bases
Group (such as-OH ,-COOH ,-NH2 ,-NH) is in polypeptide chain surface, and these architectural features assign sericin excellent tune
Wet, moisture-keeping function.
Film forming agent Aristoflex AVC used in the present invention, Chinese are acrylamide dimethyltaurine
Ammonium/VP copolymers, is primarily used in skin care item at present, is also not applied in medical resistance to hydrogel product.Selected in the present invention
Film forming agent is used it as, is that there is good stability based on it, special rheological characteristic, outstanding skin matching, and by
Its manufactured product appearance is not frivolous thick and heavy, low sticky sense, for Wound protection, has good moisturizing, the sense of pleasant skin
Feel.
Crosslinking agent used in the present invention is citric acid and triethyl citrate, citric acid be mainly used as at present acid,
Solubilizer, buffer, antioxidant, except raw meat deodorant, flavor promoting agent, gelling agent, toner etc..In addition, citric acid also has
Suppress bacterium, color protection, improve flavor, promote the effect such as sucrose inversion.Triethyl citrate is mainly used as adhesive and close at present
Seal the plasticizer of agent.Its solvability has good compatibility with many resins by force, and the product being plasticized with it has good oil resistant
Property, light resistance and fungus resistance.It is mainly used in excipient substance and capsule plasticizer processed.According to experimental data, it to eyes, skin without
Stimulation.Citric acid and triethyl citrate are not employed as the document report that crosslinking agent uses at present, are sent out in the present invention
A person of good sense chances on citric acid and triethyl citrate may be used as preparing the crosslinking of medical resistance to hydrogel by many experiments
Agent, and the two belongs to safe and non-toxic chemical reagent, to no skin irritation.
NMF used in the present invention is glycerine, and the performance of keeping humidity of glycerine is outstanding, for the medical water-fast of the present invention
The moisture retention of resistance to hydrogel product can equally be strengthened in gel.
Solvent used in the present invention is water, and pH adjusting agent is the sodium hydroxide solution of mass fraction 5%, passes through regulation
The pH value of gel, it is set to be more suitable for human body skin acid-base property, the comfort that enhancing skin uses.
The principles of chemistry of the medical resistance to hydrogel of the present invention are：Made using xanthans, sericin and Aristoflex AVC
For film forming agent, first they are sequentially added in water and is completely dissolved, then heat to 60 DEG C, be separately added into crosslinking agent citric acid and lemon
Lemon triethylenetetraminehexaacetic acid ester, xanthans, sericin and Aristoflex AVC is crosslinked reaction, make during the course of the reaction line style or
The macromolecular of slight branched chain type is transformed into tridimensional network, with property such as this intensity, wearability and solvent resistance that improve gel
Can, while stable gel state is kept, pH value, filling sterilizing are then adjusted again.
The present invention compared with prior art, has the following advantages that：
1. it is the original non-stimulated to skin safe using brand-new film forming agent xanthans, sericin and Aristoflex AVC
Material, and it is all good with skin contact compatibility, stability, moisture retention, provide new approaches for existing medical water-fast gel material；
2. using brand-new crosslinking agent citric acid and triethyl citrate, reaction is crosslinked well with film forming agent, and belong to public
The safe and non-stimulating compound recognized, avoid excitant and harmfulness of the conventional cross-linking agent glutaraldehyde to skin；
3. providing a kind of new medical resistance to hydrogel, the raw material that product formula uses is safe and non-stimulating composition, to skin
Skin is friendly, and product film forming, water resistance, the load property of medicine are relatively good, have expanded application field of the resistance to hydrogel in medical treatment situation.
The medical resistance to hydrogel of the present invention be using water as solvent, using xanthans, sericin, Aristoflex AVC as
Film forming agent, using low-molecular-weight organic compound citric acid and triethyl citrate as crosslinking agent, match somebody with somebody according to specific process
Make the waterproof gel product formed.The gel products of the present invention are applied to the film formed on skin, there is excellent waterproof
Performance and performance of keeping humidity, can blocks dust, prevent bacterium, virus, fungi invasion, simultaneously because its good performance of keeping humidity,
Epidermal growth and reparation are not only contributed to, can also avoid film from being bonded with skin wound, alleviate patient suffering.The present invention
Resistance to hydrogel can be widely used for burning, scald, the small surface of a wound of body surface such as skin injury；Dermatitis, eczema, psoriasis, tinea of feet and hands etc.
The protection treatment of disease of skin skin lesion；Laser postoperative wound cools and moisturizing, prevents bacterium, virus, fungi invasion, and various
The reparation of skin caused by skin barrier function is not complete, improves healing ability, recovers skin barrier function, reduce scar tissue shape
Into avoiding pigmentation, promote skin wound healing.
Brief description of the drawings
Fig. 1 is the image that gel products made from the embodiment of the present invention 1 amplify obtained by 100 times under the microscope.
Embodiment
Embodiment 1
A kind of preparation method of medical resistance to hydrogel of the present embodiment, comprises the steps：
（1）Xanthans 2kg, sericin 0.5kg and Aristoflex AVC 0.25kg are taken, is sequentially added in 91.65kg water,
It is stirring while adding, obtain mixed liquor A；
（2）Mixed liquor A is heated to 60 DEG C, the aqueous citric acid solution that mass fraction is 10% is slowly added dropwise in mixed liquor A
0.14kg, it was added dropwise to complete within 5 minutes, maintains the temperature at 60 DEG C, and uniform stirring 1.5 hours, obtain mixed liquid B；
（3）Triethyl citrate 0.14kg is added in mixed liquid B, was added dropwise to complete within 5 minutes, maintains the temperature at 60 DEG C,
And uniform stirring 0.5 hour, obtain mixed liquor C；
（4）Glycerine 5kg is added in mixed liquor C to stir, and obtains gel runic；
（5）The lower pH to 5.5 that gel is adjusted with the sodium hydroxide solution that mass fraction is 5% of stirring, naturally cools to room temperature, quiet
Deaeration is put, it is filling, irradiation sterilization, produce.
The xanthans is dusty raw materials of the purity more than 95% using molecular weight more than 1,000,000；
The sericin be use purity for more than 99% water-soluble silk glue protein powder；
The Aristoflex AVC, Chinese are acrylamide dimethyltaurine ammonium/VP copolymers, be use purity for
More than 92% dusty raw materials；
The citric acid be use mass fraction for 10% aqueous citric acid solution；
The triethyl citrate be use purity for more than 99% food-class liquid raw material；
The glycerine is to use medical pure glycerin；
The pH adjusting agent be use mass fraction for 5% sodium hydroxide solution.
Gel products made from embodiment 1 are subjected to performance test, concrete condition is as follows：
Experiment one, microscope detection
Gel products made from embodiment 1 are uniformly applied to long 10 centimetres, on wide 2 centimetres of glass plate, smearing thickness is 2 millis
Meter, it is placed in after the completion of smearing in 37 DEG C of insulating boxs 30 minutes, gel drying film forming, slide is put and observed under the microscope, is put
Big 100 times of gained picture is as shown in Figure 1.As shown in Figure 1, gel products made from the present embodiment are in 100 power microscope pictures
Intensive network structure is shown, it is that a kind of inside has the production for stablizing network structure to illustrate gel products made from the present embodiment
Product.
Experiment two：
Emulate the experiment of film forming waterproof：Gel products made from embodiment 1 are uniformly applied to long 10 centimetres, wide 2 centimetres of glass
On plate, smearing thickness is 2 millimeters, is placed in after the completion of smearing in 37 DEG C of insulating boxs 30 minutes, gel drying film forming is complete by the film
Take off, be placed in 40 DEG C of warm water, soak 1 hour, remain in that membrane structure is complete.Illustrate gel products made from the present embodiment
Water resistance is excellent.
Experiment three：
Skin film forming waterproof is tested：Gel products made from embodiment 1 are uniformly applied to subject's the back of the hand, smearing thickness 2mm,
Gel drying film forming after 10-30 minutes, hand is immersed in 40 DEG C of warm water, the film soaked after 15 minutes warm water, remained in that
Membrane structure is complete, illustrates that gel products water resistance is excellent made from the present embodiment.
Embodiment 2
A kind of preparation method of medical resistance to hydrogel of the present embodiment, comprises the steps：
（1）Xanthans 3kg, sericin 0.8kg and Aristoflex AVC 0.1kg are taken, is sequentially added in 95kg water, Bian Jia
Side is stirred, and obtains mixed liquor A；
（2）Mixed liquor A is heated to 65 DEG C, the aqueous citric acid solution that mass fraction is 10% is slowly added dropwise in mixed liquor A
0.5kg, it was added dropwise to complete within 5 minutes, maintains the temperature at 65 DEG C, and uniform stirring 1.3 hours, obtain mixed liquid B；
（3）Triethyl citrate 0.8kg is added in mixed liquid B, was added dropwise to complete within 5 minutes, maintains the temperature at 65 DEG C, and
Uniform stirring 0.6 hour, obtains mixed liquor C；
（4）Glycerine 3kg is added in mixed liquor C to stir, and obtains gel runic；
（5）The lower pH to 5.0 that gel is adjusted with the sodium hydroxide solution that mass fraction is 5% of stirring, naturally cools to room temperature, quiet
Deaeration is put, it is filling, irradiation sterilization, produce.
All ingredient requirements are the same as embodiment 1.
Embodiment 3
A kind of preparation method of medical resistance to hydrogel of the present embodiment, comprises the steps：
（1）Xanthans 0.1kg, sericin 0.11kg and Aristoflex AVC 0.6kg are taken, is sequentially added in 98kg water, side
Edged stirs, and obtains mixed liquor A；
（2）Mixed liquor A is heated to 55 DEG C, the aqueous citric acid solution that mass fraction is 10% is slowly added dropwise in mixed liquor A
0.01kg, it was added dropwise to complete within 5 minutes, maintains the temperature at 55 DEG C, and uniform stirring 1.0 hours, obtain mixed liquid B；
（3）Triethyl citrate 0.04kg is added in mixed liquid B, was added dropwise to complete within 5 minutes, maintains the temperature at 55 DEG C,
And uniform stirring 0.4 hour, obtain mixed liquor C；
（4）Glycerine 8kg is added in mixed liquor C to stir, and obtains gel runic；
（5）The lower pH to 6.0 that gel is adjusted with the sodium hydroxide solution that mass fraction is 5% of stirring, naturally cools to room temperature, quiet
Deaeration is put, it is filling, irradiation sterilization, produce.
All ingredient requirements are the same as embodiment 1.
Embodiment 4
A kind of preparation method of medical resistance to hydrogel of the present embodiment, comprises the steps：
（1）Xanthans 5kg, sericin 1kg and Aristoflex AVC 1kg are taken, is sequentially added in 85kg water, side edged stirs
Mix, obtain mixed liquor A；
（2）Mixed liquor A is heated to 65 DEG C, the aqueous citric acid solution 1kg that mass fraction is 10% is slowly added dropwise in mixed liquor A,
It was added dropwise to complete within 5 minutes, maintains the temperature at 65 DEG C, and uniform stirring 1.0 hours, obtain mixed liquid B；
（3）Triethyl citrate 1kg is added in mixed liquid B, was added dropwise to complete within 5 minutes, maintains the temperature at 65 DEG C, and
Even stirring 0.6 hour, obtains mixed liquor C；
（4）Glycerine 6kg is added in mixed liquor C to stir, and obtains gel runic；
（5）The pH to 4.5 of gel is adjusted with the sodium hydroxide solution that mass fraction is 5%, naturally cools to room temperature, standing and defoaming,
It is filling, irradiation sterilization, produce.
All ingredient requirements are the same as embodiment 1.
Above-described embodiment is designed solely for the purpose of illustration the specific preparation method of the present invention, does not limit this hair in any form
It is bright, anyone product related to product of the present invention according to the prescription of the claims in the present invention, principle production, preparation, belong to
The protection domain of the claims in the present invention.
Claims (9)
1. a kind of medical resistance to hydrogel, it is characterised in that be made up of the raw material of following weight parts：
Xanthans 0.1-5 sericins 0.1-1
Aristoflex AVC 0.1-1 citric acids 0.01-1
Triethyl citrate 0.01-1 glycerine 3-8
Deionized water 85-98.
2. the medical resistance to hydrogel of one kind according to claim 1, it is characterised in that be made up of the raw material of following weight parts：
Xanthans 0.1-3 sericins 0.1-0.8
Aristoflex AVC 0.1-0.6 citric acids 0.1-0.5
Triethyl citrate 0.1-0.5 glycerine 4-6
Deionized water 85-95.
3. the medical resistance to hydrogel of one kind according to claim 1, it is characterised in that be made up of the raw material of following weight parts：
The sericin 0.5 of xanthans 2
The citric acids 0.14 of Aristoflex AVC 0.25
The glycerine 5 of triethyl citrate 0.14
Water 91.65.
A kind of 4. medical resistance to hydrogel according to claim 1 or 2 or 3, it is characterised in that：The xanthans is to use to divide
Son amount is more than 1,000,000, dusty raw materials of the purity more than 95%.
A kind of 5. medical resistance to hydrogel according to claim 1 or 2 or 3, it is characterised in that：The sericin is to use
Purity is more than 99% water-soluble silk glue protein powder.
A kind of 6. medical resistance to hydrogel according to claim 1 or 2 or 3, it is characterised in that：The Aristoflex AVC
Be use purity for more than 92% dusty raw materials.
A kind of 7. medical resistance to hydrogel according to claim 1 or 2 or 3, it is characterised in that：The citric acid is to use matter
Measure the aqueous citric acid solution that fraction is 10%.
A kind of 8. medical resistance to hydrogel according to claim 1 or 2 or 3, it is characterised in that：The triethyl citrate is
Use purity for more than 99% food-class liquid raw material.
9. a kind of preparation method of medical resistance to hydrogel according to claim 1 or 2 or 3, is made up of following step successively：
（1）Xanthans, sericin and Aristoflex AVC are taken by formula rate, sequentially adds in water and dissolves, side edged stirs
Mix, obtain mixed liquor A；
（2）Mixed liquor A is heated to 55-65 DEG C, the citric acid that the mass fraction being slowly added dropwise in mixed liquor A is 10% is water-soluble
Liquid, be added dropwise to complete within 5 minutes, add citric acid quality be mixed liquor A Solute mass sum 1-10%, keeping temperature
At 60 DEG C, and uniform stirring 1-1.5 hours, obtain mixed liquid B；
（3）Triethyl citrate is added in mixed liquid B, add the quality of triethyl citrate for mixed liquor A Solute mass it
The 1-10% of sum, it was added dropwise to complete within 5 minutes, maintains the temperature at 60 DEG C, and uniform stirring 0.4-0.6 hours, obtain mixed liquor C；
（4）Glycerine is added in mixed liquor C to stir, and adds the 3-8% that qualities of glycerin is mixed liquor C mass, it is thick to obtain gel
Body；
（5）The pH to 4.5-6.0 of gel runic, natural cooling are adjusted with the sodium hydroxide solution that mass fraction is 5% under agitation
To room temperature, standing and defoaming is filling, irradiation sterilization, produces.
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| CN112316108A (en) * | 2019-07-17 | 2021-02-05 | 蘑法生物科技股份有限公司 | Compositions and methods for promoting and treating chronic wound healing |
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| US20140322329A1 (en) * | 2010-12-09 | 2014-10-30 | Zambon S.P.A. | Multipurpose gel for vaginal dryness with direct and delayed effect |
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| CN112316108A (en) * | 2019-07-17 | 2021-02-05 | 蘑法生物科技股份有限公司 | Compositions and methods for promoting and treating chronic wound healing |
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