CN105169460B - A kind of magnetic therapy antibacterial anti hemorrhagic dressing and preparation method thereof - Google Patents
A kind of magnetic therapy antibacterial anti hemorrhagic dressing and preparation method thereof Download PDFInfo
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- CN105169460B CN105169460B CN201510699965.9A CN201510699965A CN105169460B CN 105169460 B CN105169460 B CN 105169460B CN 201510699965 A CN201510699965 A CN 201510699965A CN 105169460 B CN105169460 B CN 105169460B
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- 238000002653 magnetic therapy Methods 0.000 title claims abstract description 48
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- 238000002360 preparation method Methods 0.000 title claims abstract description 26
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 74
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Abstract
The invention belongs to medical dressing fields, and in particular to a kind of magnetic therapy antibacterial anti hemorrhagic dressing and preparation method thereof.The magnetic therapy antibacterial anti hemorrhagic dressing is counted in parts by weight to be made of following component：0.5 ~ 4 part of alginate, 0.5 ~ 6 part of chitosan, 0.5 ~ 4 part of crosslinking agent, 0.1 ~ 2 part of permanent magnet nanoparticle, 0.5 ~ 4 part of nano silicon dioxide, 0.005 ~ 0.5 part of growth factor.Magnetic therapy antibacterial anti hemorrhagic dressing provided by the invention can quick-acting haemostatic powder, antibacterial anti-inflammatory, the healing for promoting wound.Dressing preparation process is simple, and the dressing stability that this method is prepared is good, easy to carry.
Description
Technical field
The invention belongs to medical dressing fields, and in particular to a kind of magnetic therapy antibacterial anti hemorrhagic dressing and preparation method thereof.
Background technology
Skin energy long term storage charge or holding polarized state, magnetic fields influence the electric current point of human body in tissue
Cloth, the movement of Charge particle, the permeability of membranous system and the equimolecular magnetic moment orientation effect of biology, make histiocytic physiology,
Biochemical process changes, and cutaneous vasodilation and blood circulation is caused to increase, and plays promoting blood circulation and removing blood stasis, swelling and pain relieving, wound is promoted to be cured
The effect of conjunction.Most of electrostatic or magnetic therapy are used for the symptoms such as set a broken bone, joint at present, the comparison for clinical wound care
It is few.
Chitosan, alginates etc. are natural active biomaterials, not only have good biocompatibility, degradable
Property, and with antibacterial, hemostasis, promotion wound healing and other effects.Nano silicon dioxide not only has antibacterial activity, but also has
Adsorption function is a kind of good medical material.Growth factor is a kind of active factors with stimulating cellular growth, development,
It can promote the healing of skin and mucous membrane wound face, reduce scar contracture and skin deformity hyperplasia, accelerate the epidermises such as cornea, skin
The reparation of wound.In addition, growth factor can also promote Skin Cell to the absorption of nutriment, accelerate the new old generation of cell
It thanks, promotes the division and growth of Skin Cell, promote the synthesis of hyaluronic acid and glycoprotein, play the role of tender skin.
It is used for treating the surface of a wound, hemostasis and pain-relieving in clinical at present, promotes wound healing, inhibits the product of scar to be single mostly
Functional dressings or dressing and drug be used in combination.Single functional dressings have centainly compared with traditional dressing
Hemostasis, promotes the functions such as wound healing at antibacterial, but effect is effective.Although drug effect, than more significant, drug is easy to make
People generates side reaction, influences health, and skin surface is limited to the absorption of drug, greatly reduces the effect of drug.
Substance with magnetic therapy functions is added in functional dressing, physical curative effect and the effect of biological dressing are joined together,
Research for treating the surface of a wound, hemostasis and pain-relieving, promotion wound healing, inhibition scar, antibacterial etc. has not been reported at present.
Invention content
Technical problem to be solved by the invention is to provide a kind of magnetic therapy antibacterial anti hemorrhagic dressing and preparation method thereof, use this
Substance with magnetic therapy functions is added in functional dressing by magnetic therapy antibacterial anti hemorrhagic dressing prepared by method, by physical curative effect
It joins together with the effect of biological dressing, the treatment surface of a wound, hemostasis and pain-relieving, promotion wound healing, inhibition scar, antibacterial etc. pass through
The magnetotherapy effect of the dressing increases the cycle of cutaneous vasodilation and blood, plays the role of anti-inflammatory analgetic, promotes wound healing；
Can stimulating cellular growth, development, reduce scar, repair damaged cell, soft skin；Have simultaneously and absorbs oozing of blood, antibacterial, hemostasis
Effect.
The object of the present invention is to provide a kind of magnetic therapy antibacterial anti hemorrhagic dressing and preparation method thereof, the magnetic therapy antibacterial anti hemorrhagic dressing
Middle chitosan and sodium alginate can form three-dimensional space net structure with cross-linking reaction, by magnetic mesoporous Silica-coated its
In, then under the action of crosslinking agent, form microparticle.
Technical scheme is as follows：A kind of magnetic therapy antibacterial anti hemorrhagic dressing, counts be made of following component in parts by weight：
Further, the alginate is sodium alginate.
Further, the deacetylation of the chitosan is more than 95%, and molecular mass is 10000~20000Da.The shell
Glycan has good antibacterial property and absorbable and degradable.
Preferably, the crosslinking agent is calcium chloride.It can be by alginate, chitosan and magnetic mesoporous silica packet
It buries, is prepared into microsphere particle, which can quickly absorb oozing of blood sepage, play hemostasis, antibacterial, analgesic, promote wound
The effect of healing.
Further, the ferromagnetic nanoparticle of the permanent magnetism is neodymium-iron-boron abrasive grit, magnetic field intensity be 0.15~0.35 it is special this
It draws.
Preferably, the aperture of the nano silicon dioxide is 20~80 μm.Permanent magnet nanoparticle can be not only adsorbed, is prepared
Magnetic mesoporous silica increases the cycle of cutaneous vasodilation and blood by magnetotherapy effect, plays anti-inflammatory analgetic, promotes wound
The effect of mouth healing；And a large amount of calcium ions can be adsorbed, play the role of quick-acting haemostatic powder.
Further, the growth factor is fibroblast growth factor or epithelical cell growth factor.It can pierce
Sharp cell growth, development, the healing of promotion skin and the mucous membrane surface of a wound, reduction scar contracture and skin deformity hyperplasia, acceleration cornea,
The reparation of the superficial wounds such as skin.It can also promote Skin Cell to the absorption of nutriment simultaneously, accelerate the new old generation of cell
It thanks, promotes the division and growth of Skin Cell, promote the synthesis of hyaluronic acid and glycoprotein, play the role of tender skin.
Further, the preparation method specific process step is as follows：
S1. alginate is dissolved in purified water, is mixed and stirred for 0.5h~1h to uniform, is prepared into solution A；By shell
Glycan is dissolved in the acetic acid solution that mass fraction is 1%, is mixed and stirred for 0.5h~1h to uniform, is prepared into solution B；
S2. solution A obtained in S1 is slowly added in solution B, is mixed and stirred for reaction 0.5h~1h to uniform, preparation
At solution C；
S3. permanent magnet nanoparticle is dispersed directly into the sodium hydroxide that the mass fraction containing nano silicon dioxide is 8%
Inorganic silicon source embedding is carried out in solution, and the permanent magnet nanoparticle for completing inorganic silicon source embedding is distributed in aqueous solution, is added
Cetyl trimethylammonium bromide template and ethyl orthosilicate carry out mesoporous silicon oxide cladding, and reactant is carried out magnetic point
From, washing, dry except after impurity, being calcined 5~7 hours in 500 DEG C, magnetic mesoporous silica is formed, by magnetic mesoporous dioxy
SiClx is slowly added in S2 in solution C obtained, is prepared into solution D；
S4. crosslinking agent is dissolved in purified water, is prepared into solution E, solution D is slowly sprayed into solution E, then through spraying
It is dry, it is prepared into the flour F that grain size is 100~200 mesh；
S5. growth factor is slowly added in substance F, is stirred, after stirring 0.5h~1h, be mixed into solid powder G；
S6. by solid powder G filling and sealings and outer packing, radiation sterilization is then carried out again and is stopped up to the magnetic therapy antibacterial
Blood dressing.
Further, magnetic mesoporous silica is distributed in chitosan alginate soln and makes again by described S3, S4
The standby stability that product can be improved at microsphere particle prevents during packing, sterilizing magnetisable material by containing metal
Object adsorbs.
Further, the S5 can prevent growth factor from not influenced by high temperature and pressure, keep its high activity.
Beneficial effects of the present invention are：(1) present invention uses magnetic therapy antibacterial anti hemorrhagic dressing prepared by this method by alginic acid
Salt, chitosan and magnetic mesoporous silicon dioxide embedded, are prepared into microsphere particle, which can quickly absorb oozing of blood and ooze
Liquid plays hemostasis, antibacterial, analgesic, the effect for promoting wound healing.(2) mesoporous silicon oxide is adsorbed into permanent magnet nanoparticle, system
Standby magnetic mesoporous silica can not only be increased the cycle of cutaneous vasodilation and blood by magnetotherapy effect, play anti-inflammatory
Analgesic, the effect for promoting wound healing；And magnetic mesoporous silica can also adsorb a large amount of calcium ions, play quick-acting haemostatic powder
Effect.(3) growth factor can stimulating cellular growth, development, promote skin and the mucous membrane surface of a wound healing, reduce scar contracture
With skin deformity hyperplasia, accelerate the reparation of the superficial wounds such as cornea, skin.Skin Cell can also be promoted to nutriment simultaneously
Absorption, accelerate the metabolism of cell, promote the division and growth of Skin Cell, promote the conjunction of hyaluronic acid and glycoprotein
At playing the role of tender skin.(4) preparation process of the invention does not destroy the active matter function in product, does not influence product quality
Stability, magnetic therapy and functional dressings are used in combination, therapeutic effect can be significantly improved.
Specific implementation mode
With reference to embodiment, the following further describes the technical solution of the present invention.
Embodiment 1
A kind of magnetic therapy antibacterial anti hemorrhagic dressing, counts be made of following component in parts by weight：0.5 part of alginate, chitosan
0.5 part, 0.5 part of crosslinking agent, 0.1 part of permanent magnet nanoparticle, 0.5 part of nano silicon dioxide, 0.005 part of growth factor.The sea
Alginates are sodium alginate, and the crosslinking agent is calcium chloride, and the deacetylation of the chitosan is more than 95%, molecular mass
For 10000~20000Da；The ferromagnetic nanoparticle of the permanent magnetism is neodymium-iron-boron abrasive grit, magnetic field intensity be 0.15~0.35 it is special this
It draws；The aperture of the nano silicon dioxide is 20~80 μm；The growth factor is fibroblast growth factor or epidermis
Porcine HGF.
A kind of preparation method of magnetic therapy antibacterial anti hemorrhagic dressing, includes the following steps：
S1. alginate is dissolved in purified water, is mixed and stirred for 0.5h~1h to uniform, is prepared into solution A；By shell
Glycan is dissolved in the acetic acid solution that mass fraction is 1%, is mixed and stirred for 0.5h~1h to uniform, is prepared into solution B；
S2. solution A obtained in S1 is slowly added in solution B, is mixed and stirred for reaction 0.5h~1h to uniform, preparation
At solution C；
S3. permanent magnet nanoparticle is dispersed directly into the sodium hydroxide that the mass fraction containing nano silicon dioxide is 8%
Inorganic silicon source embedding is carried out in solution, and the permanent magnet nanoparticle for completing inorganic silicon source embedding is distributed in aqueous solution, is added
Cetyl trimethylammonium bromide template and ethyl orthosilicate carry out mesoporous silicon oxide cladding, and reactant is carried out magnetic point
From, washing, dry except after impurity, being calcined 5~7 hours in 500 DEG C, magnetic mesoporous silica is formed, by magnetic mesoporous dioxy
SiClx is slowly added in S2 in solution C obtained, is prepared into solution D；
S4. crosslinking agent is dissolved in purified water, is prepared into solution E, solution D is slowly sprayed into solution E, then through spraying
It is dry, it is prepared into the flour F that grain size is 100~200 mesh；
S5. growth factor is slowly added in substance F, is stirred, after stirring 0.5h~1h, be mixed into solid powder G；
S6. it by solid powder G filling and sealings and outer packing, then carries out radiation sterilization again and obtains the magnetic therapy antibacterial stopping
Blood dressing.
Embodiment 2
A kind of magnetic therapy antibacterial anti hemorrhagic dressing and preparation method thereof, counts be made of following component in parts by weight：Alginate 2
Part, 3 parts of chitosan, 2 parts of crosslinking agent, 1 part of permanent magnet nanoparticle, 2 parts of nano silicon dioxide, 0.2 part of growth factor.The seaweed
Hydrochlorate is sodium alginate, and the crosslinking agent is calcium chloride, and the deacetylation of the chitosan is more than 95%, and molecular mass is
10000~20000Da；The ferromagnetic nanoparticle of the permanent magnetism is neodymium-iron-boron abrasive grit, and magnetic field intensity is 0.15~0.35 tesla；
The aperture of the nano silicon dioxide is 20~80 μm；The growth factor is fibroblast growth factor or epidermal cell
Growth factor.
A kind of preparation method of magnetic therapy antibacterial anti hemorrhagic dressing, includes the following steps：
S1. alginate is dissolved in purified water, is mixed and stirred for 0.5h~1h to uniform, is prepared into solution A；By shell
Glycan is dissolved in the acetic acid solution that mass fraction is 1%, is mixed and stirred for 0.5h~1h to uniform, is prepared into solution B；
S2. solution A obtained in S1 is slowly added in solution B, is mixed and stirred for reaction 0.5h~1h to uniform, preparation
At solution C；
S3. permanent magnet nanoparticle is dispersed directly into the sodium hydroxide that the mass fraction containing nano silicon dioxide is 8%
Inorganic silicon source embedding is carried out in solution, and the permanent magnet nanoparticle for completing inorganic silicon source embedding is distributed in aqueous solution, is added
Cetyl trimethylammonium bromide template and ethyl orthosilicate carry out mesoporous silicon oxide cladding, and reactant is carried out magnetic point
From, washing, dry except after impurity, being calcined 5~7 hours in 500 DEG C, magnetic mesoporous silica is formed, by magnetic mesoporous dioxy
SiClx is slowly added in S2 in solution C obtained, is prepared into solution D；
S4. crosslinking agent is dissolved in purified water, is prepared into solution E, solution D is slowly sprayed into solution E, then through spraying
It is dry, it is prepared into the flour F that grain size is 100~200 mesh；
S5. growth factor is slowly added in substance F, is stirred, after stirring 0.5h~1h, be mixed into solid powder G；
S6. it by solid powder G filling and sealings and outer packing, then carries out radiation sterilization again and obtains the magnetic therapy antibacterial stopping
Blood dressing.
Embodiment 3
A kind of magnetic therapy antibacterial anti hemorrhagic dressing and preparation method thereof, counts be made of following component in parts by weight：Alginate 4
Part, 6 parts of chitosan, 4 parts of crosslinking agent, 2 parts of permanent magnet nanoparticle, 4 parts of nano silicon dioxide, 0.5 part of growth factor.The seaweed
Hydrochlorate is sodium alginate, and the crosslinking agent is calcium chloride, and the deacetylation of the chitosan is more than 95%, and molecular mass is
10000~20000Da；The ferromagnetic nanoparticle of the permanent magnetism is neodymium-iron-boron abrasive grit, and magnetic field intensity is 0.15~0.35 tesla；
The aperture of the nano silicon dioxide is 20~80 μm；The growth factor is fibroblast growth factor or epidermal cell
Growth factor.
A kind of preparation method of magnetic therapy antibacterial anti hemorrhagic dressing, includes the following steps：
S1. alginate is dissolved in purified water, is mixed and stirred for 0.5h~1h to uniform, is prepared into solution A；By shell
Glycan is dissolved in the acetic acid solution that mass fraction is 1%, is mixed and stirred for 0.5h~1h to uniform, is prepared into solution B；
S2. solution A obtained in S1 is slowly added in solution B, is mixed and stirred for reaction 0.5h~1h to uniform, preparation
At solution C；
S3. permanent magnet nanoparticle is dispersed directly into the sodium hydroxide that the mass fraction containing nano silicon dioxide is 8%
Inorganic silicon source embedding is carried out in solution, and the permanent magnet nanoparticle for completing inorganic silicon source embedding is distributed in aqueous solution, is added
Cetyl trimethylammonium bromide template and ethyl orthosilicate carry out mesoporous silicon oxide cladding, and reactant is carried out magnetic point
From, washing, dry except after impurity, being calcined 5~7 hours in 500 DEG C, magnetic mesoporous silica is formed, by magnetic mesoporous dioxy
SiClx is slowly added in S2 in solution C obtained, is prepared into solution D；
S4. crosslinking agent is dissolved in purified water, is prepared into solution E, solution D is slowly sprayed into solution E, then through spraying
It is dry, it is prepared into the flour F that grain size is 100~200 mesh；
S5. growth factor is slowly added in substance F, is stirred, after stirring 0.5h~1h, be mixed into solid powder G；
S6. it by solid powder G filling and sealings and outer packing, then carries out radiation sterilization again and obtains the magnetic therapy antibacterial stopping
Blood dressing.
To verify whether magnetic therapy antibacterial anti hemorrhagic dressing of the present invention reaches expected invention effect, magnetic therapy antibacterial of the present invention is stopped
Blood dressing carries out antibacterial tests and animal experiment analysis, as a result as follows：
It includes staphylococcus aureus, bacillus subtilis, coliform to lead to the pathogenic bacteria of gynaecology and infected wound mainly
Group, hemolytic streptococcus etc., this experiment is with the antibacterial effect of 1~3 magnetic therapy antibacterial anti hemorrhagic dressing of above-mentioned pathogenic bacteria testing example.
As can be seen from the above table, the magnetic therapy antibacterial anti hemorrhagic dressing that prepared by the present invention has good antibacterial effect to most of pathogenic bacteria,
There is good haemostatic effect, biocompatibility, and safety non-toxic simultaneously, can use safely, supporting for skin can be improved
Drag promotes the metabolic capabilities of skin, and sterile healing environment can be provided to wound, promotes the healing of wound.
Embodiment 4
To verify magnetic therapy antibacterial anti hemorrhagic dressing of the present invention in the upper superiority of formula, the present invention is tested as follows.
Experimental group：A kind of magnetic therapy antibacterial anti hemorrhagic dressing and preparation method thereof, counts be made of following component in parts by weight：Sea
2 parts of alginates, 3 parts of chitosan, 2 parts of crosslinking agent, 1 part of permanent magnet nanoparticle, 2 parts of nano silicon dioxide, 0.2 part of growth factor.
Control group 1：A kind of magnetic therapy antibacterial anti hemorrhagic dressing and preparation method thereof, counts be made of following component in parts by weight：
3 parts of chitosan, 2 parts of crosslinking agent, 1 part of permanent magnet nanoparticle, 2 parts of nano silicon dioxide, 0.2 part of growth factor.
Control group 2：A kind of magnetic therapy antibacterial anti hemorrhagic dressing and preparation method thereof, counts be made of following component in parts by weight：
2 parts of alginate, 2 parts of crosslinking agent, 1 part of permanent magnet nanoparticle, 2 parts of nano silicon dioxide, 0.2 part of growth factor.
Control group 3：A kind of magnetic therapy antibacterial anti hemorrhagic dressing and preparation method thereof, counts be made of following component in parts by weight：
2 parts of alginate, 3 parts of chitosan, 1 part of permanent magnet nanoparticle, 2 parts of nano silicon dioxide, 0.2 part of growth factor.
Control group 4：A kind of magnetic therapy antibacterial anti hemorrhagic dressing and preparation method thereof, counts be made of following component in parts by weight：
2 parts of alginate, 3 parts of chitosan, 2 parts of crosslinking agent, 1 part of permanent magnet nanoparticle, 0.2 part of growth factor.
Control group 5：A kind of magnetic therapy antibacterial anti hemorrhagic dressing and preparation method thereof, counts be made of following component in parts by weight：
2 parts of alginate, 3 parts of chitosan, 2 parts of crosslinking agent, 2 parts of nano silicon dioxide, 0.2 part of growth factor.
Control group 6：A kind of magnetic therapy antibacterial anti hemorrhagic dressing and preparation method thereof, counts be made of following component in parts by weight：
2 parts of alginate, 3 parts of chitosan, 2 parts of crosslinking agent, 1 part of permanent magnet nanoparticle, 2 parts of nano silicon dioxide.
Antibacterial tests analysis is carried out to experimental group and each control group, as a result as follows：
Compare the experimental group of upper table and control group can be seen that the magnetic therapy antibacterial anti hemorrhagic dressing for preparing of the present invention respectively at point it
Between have synergistic effect, it is indispensable.
Obviously, the above embodiment of the present invention be only to clearly illustrate example of the present invention, and not be pair
The restriction of embodiments of the present invention；For those of ordinary skill in the art, may be used also on the basis of the above description
To make other variations or changes in different ways, there is no need and unable to be enumerated to all embodiments；It is all this
All any modification, equivalent and improvement etc., should be included in the claims in the present invention made by within the spirit and principle of invention
Protection domain within.
Claims (7)
1. a kind of magnetic therapy antibacterial anti hemorrhagic dressing, which is characterized in that count be made of following component in parts by weight：
The preparation method specific process step of the magnetic therapy antibacterial anti hemorrhagic dressing is as follows：
S1. alginate is dissolved in purified water, is mixed and stirred for 0.5h~1h to uniform, is prepared into solution A；By chitosan
It is dissolved in the acetic acid solution that mass fraction is 1%, is mixed and stirred for 0.5h~1h to uniform, is prepared into solution B；
S2. solution A obtained in S1 is slowly added in solution B, is mixed and stirred for reaction 0.5h~1h to uniform, is prepared into molten
Liquid C；
S3. permanent magnet nanoparticle is dispersed directly into the sodium hydroxide solution that the mass fraction containing nano silicon dioxide is 8%
It is middle to carry out inorganic silicon source embedding, the permanent magnet nanoparticle for completing inorganic silicon source embedding is distributed in aqueous solution, adds 16
Alkyl trimethyl ammonium bromide template and ethyl orthosilicate carry out mesoporous silicon oxide cladding, by reactant carry out magnetic separation,
After washing, drying remove impurity, is calcined 5~7 hours in 500 DEG C, magnetic mesoporous silica is formed, by magnetic mesoporous silica
It is slowly added in S2 in solution C obtained, is prepared into solution D；
S4. crosslinking agent is dissolved in purified water, is prepared into solution E, solution D is slowly sprayed into solution E, then is dry through spraying
It is dry, it is prepared into the flour F that grain size is 100~200 mesh；
S5. growth factor is slowly added in substance F, is stirred, after stirring 0.5h~1h, be mixed into solid powder G；
S6. by solid powder G filling and sealings and outer packing, radiation sterilization is then carried out again and is applied up to the magnetic therapy antibacterial anti hemorrhagic
Material.
2. a kind of magnetic therapy antibacterial anti hemorrhagic dressing according to claim 1, which is characterized in that the alginate is seaweed
Sour sodium.
3. a kind of magnetic therapy antibacterial anti hemorrhagic dressing according to claim 1, which is characterized in that the chitosan it is deacetylated
Degree is more than 95%, and molecular mass is 10000~20000Da.
4. a kind of magnetic therapy antibacterial anti hemorrhagic dressing according to claim 1, which is characterized in that the crosslinking agent is chlorination
Calcium.
5. a kind of magnetic therapy antibacterial anti hemorrhagic dressing according to claim 1, which is characterized in that the permanent magnet nanoparticle is
Neodymium-iron-boron abrasive grit, magnetic field intensity are 0.15~0.35 tesla.
6. a kind of magnetic therapy antibacterial anti hemorrhagic dressing according to claim 1, which is characterized in that the hole of the nano silicon dioxide
Diameter is 20~80 μm.
7. a kind of magnetic therapy antibacterial anti hemorrhagic dressing according to claim 1, which is characterized in that the growth factor is into fiber
Porcine HGF or epithelical cell growth factor.
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| CN105999368A (en) * | 2016-07-28 | 2016-10-12 | 上海建华精细生物制品有限公司 | Epidermal growth factor compound wet wound dressing and preparation method thereof |
| US20210275440A1 (en) * | 2016-09-29 | 2021-09-09 | The University Of Memphis Research Foundation | Microbead compositions and methods for delivering an agent |
| CN106552285A (en) * | 2016-12-08 | 2017-04-05 | 苏州艾博迈尔新材料有限公司 | A kind of magnetic therapy medical function dressing and preparation method thereof |
| CN108721677B (en) * | 2017-04-17 | 2021-11-19 | 广西美丽肤医疗器械有限公司 | Composite material |
| CN107865822A (en) * | 2017-08-25 | 2018-04-03 | 中南民族大学 | A kind of preparation method and application for the pharmaceutical hydrogel slow releasing carrier material for mixing mesoporous nano silicon dioxide |
| US10525147B2 (en) | 2018-02-13 | 2020-01-07 | Imam Abdulrahman Bin Faisal University | Bionanocomposite synthesis for would healing |
| CN109223314A (en) * | 2018-09-05 | 2019-01-18 | 杨文超 | A kind of Chinese medicine dermatologic patch |
| CN110755408B (en) * | 2019-09-23 | 2021-09-03 | 中国人民解放军东部战区总医院 | Chitosan antibacterial microspheres capable of slowly releasing growth factors and preparation method and application thereof |
| CN112244966A (en) * | 2020-11-16 | 2021-01-22 | 常州安康医疗器械有限公司 | Clinical drainage puncture ware of internal medicine |
| CN112370565A (en) * | 2020-11-27 | 2021-02-19 | 河南汇博医疗股份有限公司 | Silver-containing long-acting antibacterial dressing |
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