CN105343926A - Scar patch containing nano silicon dioxide and preparation method of scar patch - Google Patents
Scar patch containing nano silicon dioxide and preparation method of scar patch Download PDFInfo
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- CN105343926A CN105343926A CN201510755628.7A CN201510755628A CN105343926A CN 105343926 A CN105343926 A CN 105343926A CN 201510755628 A CN201510755628 A CN 201510755628A CN 105343926 A CN105343926 A CN 105343926A
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- nano silicon
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- scar plaster
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 title claims abstract description 106
- 231100000241 scar Toxicity 0.000 title claims abstract description 75
- 239000005543 nano-size silicon particle Substances 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- 235000012239 silicon dioxide Nutrition 0.000 title abstract 5
- 102000008186 Collagen Human genes 0.000 claims abstract description 36
- 108010035532 Collagen Proteins 0.000 claims abstract description 36
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims abstract description 24
- 229940072056 alginate Drugs 0.000 claims abstract description 24
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 24
- 229920000615 alginic acid Polymers 0.000 claims abstract description 24
- 239000000741 silica gel Substances 0.000 claims abstract description 8
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 8
- 239000011505 plaster Substances 0.000 claims description 64
- 239000000017 hydrogel Substances 0.000 claims description 44
- 239000000377 silicon dioxide Substances 0.000 claims description 44
- 238000003756 stirring Methods 0.000 claims description 30
- -1 polydimethylsiloxane Polymers 0.000 claims description 15
- 230000001954 sterilising effect Effects 0.000 claims description 15
- 239000000499 gel Substances 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 11
- 239000003921 oil Substances 0.000 claims description 10
- 238000004659 sterilization and disinfection Methods 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical group CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 6
- 235000010413 sodium alginate Nutrition 0.000 claims description 6
- 229940005550 sodium alginate Drugs 0.000 claims description 6
- 239000000661 sodium alginate Substances 0.000 claims description 6
- 239000010409 thin film Substances 0.000 claims description 6
- 241000276701 Oreochromis mossambicus Species 0.000 claims description 5
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 5
- HIHIPCDUFKZOSL-UHFFFAOYSA-N ethenyl(methyl)silicon Chemical compound C[Si]C=C HIHIPCDUFKZOSL-UHFFFAOYSA-N 0.000 claims description 5
- XLXGCFTYXICXJF-UHFFFAOYSA-N ethylsilicon Chemical compound CC[Si] XLXGCFTYXICXJF-UHFFFAOYSA-N 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 5
- 239000001257 hydrogen Substances 0.000 claims description 5
- 229910052739 hydrogen Inorganic materials 0.000 claims description 5
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 5
- 229920001296 polysiloxane Polymers 0.000 claims description 5
- 229920002545 silicone oil Polymers 0.000 claims description 5
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 5
- 229920002554 vinyl polymer Polymers 0.000 claims description 5
- 230000035876 healing Effects 0.000 abstract description 11
- 229920001436 collagen Polymers 0.000 abstract description 7
- 230000035699 permeability Effects 0.000 abstract description 7
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 6
- 230000008439 repair process Effects 0.000 abstract description 4
- 208000032544 Cicatrix Diseases 0.000 abstract 2
- 230000037387 scars Effects 0.000 abstract 2
- 206010020718 hyperplasia Diseases 0.000 abstract 1
- 210000000589 cicatrix Anatomy 0.000 description 17
- 208000027418 Wounds and injury Diseases 0.000 description 14
- 230000000694 effects Effects 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 230000005540 biological transmission Effects 0.000 description 10
- 239000000126 substance Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 206010020880 Hypertrophy Diseases 0.000 description 6
- 210000002808 connective tissue Anatomy 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 208000003251 Pruritus Diseases 0.000 description 4
- 206010039580 Scar Diseases 0.000 description 4
- 241000276707 Tilapia Species 0.000 description 4
- 239000000427 antigen Substances 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 239000002932 luster Substances 0.000 description 4
- 239000000049 pigment Substances 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 230000008929 regeneration Effects 0.000 description 4
- 238000011069 regeneration method Methods 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 238000009792 diffusion process Methods 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 241000251468 Actinopterygii Species 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000019522 cellular metabolic process Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 239000010408 film Substances 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 238000006703 hydration reaction Methods 0.000 description 2
- 210000000835 hypertrophic cicatrix Anatomy 0.000 description 2
- 230000037311 normal skin Effects 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 238000007711 solidification Methods 0.000 description 2
- 230000008023 solidification Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010612 desalination reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 102000034240 fibrous proteins Human genes 0.000 description 1
- 108091005899 fibrous proteins Proteins 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000025366 tissue development Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention belongs to the field of a medical dressing, and in particular relates to a scar patch containing nano silicon dioxide and a preparation method of the scar patch. The scar patch containing the nano silicon dioxide consists of the following components in parts by weight: 2-5 parts of alginate, 80-100 parts of a nano silicon dioxide solution, 5-15 parts of collagen, 50-60 parts of a silica gel A component and 50-80 parts of a silica gel B component. The scar patch containing the nano silicon dioxide provided by the invention, which can provide a wet healing environment, not only can inhibit the hyperplasia of scars, but also can repair dark spots and bumps of the scars and accelerate the healing of wound surfaces; and meanwhile, the scar patch is good in antibacterial property and air permeability.
Description
Technical field
The invention belongs to medical dressing field, be specifically related to a kind of scar plaster containing nano silicon and preparation method thereof.
Background technology
In daily life, burn, after incision, wound, the infection etc. such as operation cause skin corium wound, fibroblast proliferation, easy generation hypertrophic cicatrix, exhibit tissue color purple, higher than normal skin, in the short time, pole is had much difficulty in healing multiple, causes serious appearance and spiritual influence to patient.In multiple hypertrophic cicatrix Therapeutic Method, pressure therapy, by pressure effect blood vessel, reduces blood flow, thus Inhibiting proliferation tissue development, become a kind of general Therapeutic Method.In recent years, it is rather prevailing that the scar plaster adopting Silica hydrogel to prepare carries out pressure therapy method, and evident in efficacy.
Moisture-vapor transmission is one of key index affecting scar plaster therapeutic effect, and its importance comes from steam through the significant impact in cicatrization.Human body corium is that the cyton based on fibroblast and the intercellular substance based on collagen fiber are formed, and surface is neatly smooth, after suffering wound, and collagen fiber disappearance or structure entanglement, new capillary tube and fiber are grown into, and cause cicatrix to produce; Simultaneously because scar surface horny layer is thinner, water evaporation quantity is comparatively large, increases the demand to capillary tube, promotes the hypertrophy of capillary tube, accelerates the hypertrophy of cicatrix.On the one hand, the moisture-vapor transmission of Silica hydrogel is lower, and moisture retention can be made preferably on cicatrix top layer, increases the permeability of water-soluble substances in interstitial, accelerates diffusion, reduces water-soluble substances Fluid Volume in interstitial, and cicatrix is softened.On the other hand, Silica hydrogel is covered in scar surface, reduces moisture evaporation, reduces the demand to capillary tube, suppress the increase of capillary tube, suppress the hypertrophy of cicatrix.According to pertinent literature, the moisture-vapor transmission of normal skin is 204g/(m
2.d), the moisture-vapor transmission of compromised skin is 279 ~ 5138g/(m
2.d), when the moisture-vapor transmission of dressing is lower than skin beauty water vapor transmission rates, can well for wound surface provides moistening healing environment.
Collagen protein is a kind of fibrous proteins is three helical structures, is connective tissue and important protein structure thereof, and the protein in skin about 75% is collagen protein, constantly can be formed along with self normal connective tissue, reaches the effect smoothed away wrinkles with cicatrix.Multinomial result of study and clinical test results show, use collagen film as dressing, can not only accelerate the metabolism of cell, promote the healing of wound surface, and wound surface color and luster after healing is scarlet, flat smooth, flexible.Collagen protein has no antigen, good biocompatibility, hemostatic, has a wide range of applications in medical treatment.Alginate are natural active biomaterials, have good biocompatibility, degradability, can become colloidality, water absorption.Nano silicon has good antibacterial activity, is a kind of good medical material.
Mostly there is poor air permeability in the Silica hydrogel scar plaster product of current appearance, moisture-vapor transmission crosses the shortcomings such as high, moistening healing environment can not be provided, there is the shortcoming such as hypertrophy, desalination cicatrix that effectively can not suppress cicatrix simultaneously, need the effect improving Silica hydrogel badly, meet product that is clinical and patient demand and occur.
Summary of the invention
The present invention overcomes prior art defect, provides preparation one to breathe freely, and is conducive to repairing cicatrix skin dark stain, protruding medical dressing.The object of this invention is to provide a kind of scar plaster containing nano silicon and preparation method thereof, containing nano silicon in this scar plaster, microcellular structure can be formed in scar plaster, be conducive to the breathability increasing scar plaster, the eupnea effect of skin can be guaranteed, there is certain bacteriostasis simultaneously; Containing alginate and collagen protein in scar plaster, suitable wet environment can not only be provided, suppress the growth of capillary tube, abundant collagen protein can also be provided simultaneously, repair cicatrix skin dark stain, projection, make skin level and smooth, flexible.
Technical scheme of the present invention is as follows: a kind of scar plaster containing nano silicon, counts by weight and is made up of following composition:
Alginate 2 ~ 5 parts;
Nanosilica solution 80 ~ 100 parts;
Collagen protein 5 ~ 15 parts;
Silica hydrogel component A 50 ~ 80 parts;
Silica hydrogel B component 50 ~ 80 parts.
Further, described alginate is sodium alginate.Sodium alginate has very strong water absorption, gel can be formed after water suction, moisture lock is stayed in three-dimensional netted molecular structure, alginate jelly is added in Silica hydrogel and prepares scar plaster, when being covered in wound surface, certain hydration environment can be provided, after skin water suction, inhibit the regeneration of capillary tube, thus decrease the deposition of collagen.Meanwhile, keratodermatitis water content increases, and moisture retention can be made on cicatrix top layer, increases the permeability of water-soluble substances in interstitial, accelerates diffusion, and impel cicatrix to soften and disappear, pigment shoals, and alleviates pruritus pain.
Further, in described nanosilica solution, the content of nano silicon is 5wt%, and described nano silicon particle diameter is 20 ~ 35nm.This nano silicon can be dispersed in scar plaster uniformly, in scar plaster, form microcellular structure, is conducive to the breathability increasing scar plaster, can guarantees the eupnea effect of skin, have certain bacteriostasis simultaneously.
Further, described collagen protein extracts from Java tilapia skin.Tilapia is the economic kind that China mainly cultivates, and China tilapia total output accounts for about 48% of Gross World Product according to statistics, originates very abundant.Tilapia produces the leftover bits and pieces such as a large amount of fish skin, fishbone in the process of production and processing, wherein contains a large amount of collagen protein in fish skin, and these collagen protein of Appropriate application are conducive to the added value improving tilapia, promote the development of marine industry and medical industry.Collagen protein has no antigen, good biocompatibility, and multinomial result of study and clinical test results show, use collagen film as dressing, the metabolism of cell can not only be accelerated, promote the healing of wound surface, and wound surface color and luster after healing is scarlet, flat smooth, flexible.In human body, collagen protein is the extremely important protein structure of connective tissue, constantly can be formed along with self normal connective tissue, reaches the effect smoothed away wrinkles with cicatrix.
Preferably, described Silica hydrogel component A comprises methyl vinyl silicon oil, methyl-silicone oil and ethyl silicon oil.Described Silica hydrogel B component is the polydimethylsiloxane of Methyl Hydrogen Polysiloxane Fluid and vinyl opposite end.
Further, a kind of preparation method of the scar plaster containing nano silicon, its preparation method comprises the steps:
S1. collagen protein is dissolved in nanosilica solution, stirs 0.5h ~ 1h to being uniformly dissolved, being prepared into solution E; Again alginate is dissolved in wherein, stirs 1h ~ 2h to dissolving completely, being prepared into gel F;
S2. Silica hydrogel component A is slowly added in Silica hydrogel B component, stir 0.5h ~ 1h to evenly, be prepared into AB component complex;
S3. the AB component complex prepared by S2 adds in vacuum stirring tank, then the gel F prepared by S1 slowly adds in vacuum stirring tank, is-0.8MPa ~ 0.095MPa at pressure, temperature is under 20 ~ 35 DEG C of conditions, stir 4 ~ 7h, and carry out vacuum defoamation, be prepared into product G;
S4. tile one deck silica gel thin film first in a mold, and the product G then prepared by S3 is laid on pellosil, solidifies 6 ~ 10h, finally shear again, namely subpackage, sterilizing obtain a kind of scar plaster containing nano silicon under 50 ~ 70 DEG C of conditions.
Further, in the preparation method of described a kind of scar plaster containing nano silicon, the object of S1 makes the solution containing nano silicon form gel, in order to avoid directly nanosilica solution is joined in AB component complex, reduce the viscosity of AB component complex, affect cross-linking reaction effect, and then affect the solidification effect of S4.
Further, in the preparation method of described a kind of scar plaster containing nano silicon, the object of S2, S3 makes the abundant mix homogeneously of each component, gets rid of bubble simultaneously, guarantee the solidification effect of S4.
Further, in the preparation method of described a kind of scar plaster containing nano silicon, the object of one deck silica gel thin film that tiles in S4 is to form a sticking scar plaster, can being directly attached on wound surface in use, fixing without the need to foreign object.
Preferably, the sterilization method in described S4 is irradiation sterilization, and irradiation dose is 15 ~ 25kGy.
Beneficial effect of the present invention is: containing microcellular structure in (1) scar plaster, can increase the breathability of scar plaster, can guarantee the eupnea effect of skin, have certain bacteriostasis simultaneously.(2) alginate can pin portion of water, when being covered in wound surface, can provide certain hydration environment, after skin water suction, inhibits the regeneration of capillary tube, thus decreases the deposition of collagen.Meanwhile, keratodermatitis water content increases, and moisture retention can be made on cicatrix top layer, increases the permeability of water-soluble substances in interstitial, accelerates diffusion, and impel cicatrix to soften and disappear, pigment shoals, and alleviates pruritus pain.(3) collagen protein no antigen, having good biocompatibility, is the extremely important protein structure of connective tissue, constantly can be formed along with self normal connective tissue, repair cicatrix skin dark stain, projection, make that the wound surface color and luster after healing is scarlet, flat smooth, flexible.(4) this scar plaster has good hot strength and holds viscosity, acts on affected part flexible, also can prevent after pasting or the situation generation that in use procedure, external force is broken, scar plaster also can be made firmly to be fitted in affected part, the situation generation reducing slippage and come off.(5) preparation technology of the present invention is simple, does not destroy the active matter function in product, does not affect the stability of product quality, can significantly improve Wound treating effect, meet demand that is clinical and patient.
Detailed description of the invention
Below in conjunction with embodiment, technical scheme of the present invention is described further.
embodiment 1
A kind of scar plaster containing nano silicon and preparation method thereof, counts by weight and is made up of following composition: alginate 2 parts, nanosilica solution 80 parts, collagen protein 5 parts, Silica hydrogel component A 50 parts, Silica hydrogel B component 50 parts.Described alginate is sodium alginate, and in described nanosilica solution, the content of nano silicon is 5wt%, and described nano silicon particle diameter is 20 ~ 35nm.Described collagen protein extracts from Java tilapia skin.Described Silica hydrogel component A comprises methyl vinyl silicon oil, methyl-silicone oil and ethyl silicon oil.Described Silica hydrogel B component is the polydimethylsiloxane of Methyl Hydrogen Polysiloxane Fluid and vinyl opposite end.
A kind of scar plaster containing nano silicon and preparation method thereof, preparation method comprises the steps:
S1. collagen protein is dissolved in nanosilica solution, stirs 0.5h ~ 1h to being uniformly dissolved, being prepared into solution E; Again alginate is dissolved in wherein, stirs 1h ~ 2h to dissolving completely, being prepared into gel F;
S2. Silica hydrogel component A is slowly added in Silica hydrogel B component, stir 0.5h ~ 1h to evenly, be prepared into AB component complex;
S3. the AB component complex prepared by S2 adds in vacuum stirring tank, then the gel F prepared by S1 slowly adds in vacuum stirring tank, is-0.8MPa ~ 0.095MPa at pressure, temperature is under 20 ~ 35 DEG C of conditions, stir 4 ~ 7h, and carry out vacuum defoamation, be prepared into product G;
S4. tile one deck silica gel thin film first in a mold, and the product G then prepared by S3 is laid on pellosil, solidifies 6 ~ 10h, finally shear again, namely subpackage, sterilizing obtain a kind of scar plaster containing nano silicon of product under 50 ~ 70 DEG C of conditions.
Sterilization method in described S4 is irradiation sterilization, and irradiation dose is 15 ~ 25kGy.
embodiment 2
A kind of scar plaster containing nano silicon and preparation method thereof, counts by weight and is made up of following composition: alginate 3 parts, nanosilica solution 100 parts, collagen protein 10 parts, Silica hydrogel component A 70 parts, Silica hydrogel B component 70 parts.Described alginate is sodium alginate, and in described nanosilica solution, the content of nano silicon is 5wt%, and described nano silicon particle diameter is 20 ~ 35nm.Described collagen protein extracts from Java tilapia skin.Described Silica hydrogel component A comprises methyl vinyl silicon oil, methyl-silicone oil and ethyl silicon oil.Described Silica hydrogel B component is the polydimethylsiloxane of Methyl Hydrogen Polysiloxane Fluid and vinyl opposite end.
A kind of scar plaster containing nano silicon and preparation method thereof, preparation method comprises the steps:
S1. collagen protein is dissolved in nanosilica solution, stirs 0.5h ~ 1h to being uniformly dissolved, being prepared into solution E; Again alginate is dissolved in wherein, stirs 1h ~ 2h to dissolving completely, being prepared into gel F;
S2. Silica hydrogel component A is slowly added in Silica hydrogel B component, stir 0.5h ~ 1h to evenly, be prepared into AB component complex;
S3. the AB component complex prepared by S2 adds in vacuum stirring tank, then the gel F prepared by S1 slowly adds in vacuum stirring tank, is-0.8MPa ~ 0.095MPa at pressure, temperature is under 20 ~ 35 DEG C of conditions, stir 4 ~ 7h, and carry out vacuum defoamation, be prepared into product G;
S4. tile one deck silica gel thin film first in a mold, and the product G then prepared by S3 is laid on pellosil, solidifies 6 ~ 10h, finally shear again, namely subpackage, sterilizing obtain a kind of scar plaster containing nano silicon of product under 50 ~ 70 DEG C of conditions.
Sterilization method in described S4 is irradiation sterilization, and irradiation dose is 15 ~ 25kGy.
embodiment 3
A kind of scar plaster containing nano silicon and preparation method thereof, counts by weight and is made up of following composition: alginate 5 parts, nanosilica solution 100 parts, collagen protein 15 parts, Silica hydrogel component A 80 parts, Silica hydrogel B component 80 parts.Described alginate is sodium alginate, and in described nanosilica solution, the content of nano silicon is 5wt%, and described nano silicon particle diameter is 20 ~ 35nm.Described collagen protein extracts from Java tilapia skin.Described Silica hydrogel component A comprises methyl vinyl silicon oil, methyl-silicone oil and ethyl silicon oil.Described Silica hydrogel B component is the polydimethylsiloxane of Methyl Hydrogen Polysiloxane Fluid and vinyl opposite end.
A kind of scar plaster containing nano silicon and preparation method thereof, preparation method comprises the steps:
S1. collagen protein is dissolved in nanosilica solution, stirs 0.5h ~ 1h to being uniformly dissolved, being prepared into solution E; Again alginate is dissolved in wherein, stirs 1h ~ 2h to dissolving completely, being prepared into gel F;
S2. Silica hydrogel component A is slowly added in Silica hydrogel B component, stir 0.5h ~ 1h to evenly, be prepared into AB component complex;
S3. the AB component complex prepared by S2 adds in vacuum stirring tank, then the gel F prepared by S1 slowly adds in vacuum stirring tank, is-0.8MPa ~ 0.095MPa at pressure, temperature is under 20 ~ 35 DEG C of conditions, stir 4 ~ 7h, and carry out vacuum defoamation, be prepared into product G;
S4. tile one deck silica gel thin film first in a mold, and the product G then prepared by S3 is laid on pellosil, solidifies 6 ~ 10h, finally shear again, namely subpackage, sterilizing obtain a kind of scar plaster containing nano silicon of product under 50 ~ 70 DEG C of conditions.
Sterilization method in described S4 is irradiation sterilization, and irradiation dose is 15 ~ 25kGy.
For whether checking the present invention scar plaster of containing nano silicon reaches the invention effect of expection, carry out antibacterial tests, animal experiment and testing performance index to scar plaster of the present invention, result is as follows:
As can be seen from the above table, this experiment for subjects with escherichia coli and staphylococcus aureus, is carried out anti-microbial property test to the scar plaster of embodiment 1 ~ 3, is found that this scar plaster has good antibacterial effect.The scar plaster tool that as can be seen from the above table prepared by the present invention simultaneously has the following advantages: (1) this scar plaster has good biocompatibility, and no antigen, sensitization can relievedly use; (2) this scar plaster has good OTR oxygen transmission rate, can guarantee the normal Repiration of skin; (3) moisture-vapor transmission of this scar plaster is lower, can guarantee the water content of keratodermatitis, accelerates the permeability of water-soluble substances in interstitial, and impel cicatrix to soften and disappear, pigment shoals, and alleviates pruritus pain.The regeneration of capillary tube can be suppressed simultaneously, reduce the hypertrophy of cicatrix; (4) this scar plaster has good hot strength, and effect affected part is flexible, can be covered on the places such as face, arm, joint, neck, also can prevent after pasting or the situation generation that in use procedure, external force is broken; (5) this scar plaster has strong viscosity, and scar plaster can be made firmly to be fitted in affected part, the situation generation reducing slippage and come off.
embodiment 4
For checking the present invention contains scar plaster superiority on formula of nano silicon, the present invention tests as follows.
Experimental group: a kind of scar plaster containing nano silicon and preparation method thereof, counts by weight and is made up of following composition: alginate 3 parts, nanosilica solution 100 parts, collagen protein 10 parts, Silica hydrogel component A 70 parts, Silica hydrogel B component 70 parts.
Matched group 1: a kind of scar plaster containing nano silicon and preparation method thereof, counts by weight and is made up of following composition: nanosilica solution 100 parts, collagen protein 10 parts, Silica hydrogel component A 70 parts, Silica hydrogel B component 70 parts.
Matched group 2 one kinds scar plaster containing nano silicon and preparation method thereof, counts by weight and is made up of following composition: alginate 3 parts, collagen protein 10 parts, Silica hydrogel component A 70 parts, Silica hydrogel B component 70 parts.
Matched group 3: a kind of scar plaster containing nano silicon and preparation method thereof, counts by weight and is made up of following composition: alginate 3 parts, nanosilica solution 100 parts, Silica hydrogel component A 70 parts, Silica hydrogel B component 70 parts.
Carry out antibacterial tests analysis to experimental group and each matched group, result is as follows:
The experimental group that contrast is shown and matched group can find out to have synergism between each composition of scar plaster prepared by the present invention, indispensable.
(1) can be found by contrast experiment's group and matched group 1, alginate plays an important role in scar plaster, and its existence can guarantee the water content of keratodermatitis, accelerate the permeability of water-soluble substances in interstitial, impel cicatrix to soften to disappear, pigment shoals, and alleviates pruritus pain.The regeneration of capillary tube can be suppressed simultaneously, reduce the hypertrophy of cicatrix, make skin smooth flexible.
(2) can be found by contrast experiment's group and matched group 2, nano silicon plays an important role in scar plaster, and its existence can make scar plaster have good OTR oxygen transmission rate, can guarantee the normal Repiration of skin, play antibacterial action simultaneously.
(3) can be found by contrast experiment's group and matched group 3, collagen protein plays an important role in scar plaster, and its existence can repair cicatrix skin dark stain, projection, makes that the wound tissue color and luster after healing is scarlet, flat smooth, flexible.
Obviously, the above embodiment of the present invention is only for example of the present invention is clearly described, and is not the restriction to embodiments of the present invention; For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description, exhaustive without the need to also giving all embodiments here; All any amendments done within the spirit and principles in the present invention, equivalent to replace and improvement etc., within the protection domain that all should be included in the claims in the present invention.
Claims (8)
1. the scar plaster containing nano silicon, is characterized in that, count by weight and be made up of following composition:
Alginate 2 ~ 5 parts;
Nanosilica solution 80 ~ 100 parts;
Collagen protein 5 ~ 15 parts;
Silica hydrogel component A 50 ~ 80 parts;
Silica hydrogel B component 50 ~ 80 parts.
2. a kind of scar plaster containing nano silicon according to claim 1, it is characterized in that, described alginate is sodium alginate.
3. a kind of scar plaster containing nano silicon according to claim 1, it is characterized in that, in described nanosilica solution, the content of nano silicon is 5wt%, and described nano silicon particle diameter is 20 ~ 35nm.
4. a kind of scar plaster containing nano silicon according to claim 1, it is characterized in that, described collagen protein extracts from Java tilapia skin.
5. a kind of scar plaster containing nano silicon according to claim 1, it is characterized in that, described Silica hydrogel component A comprises methyl vinyl silicon oil, methyl-silicone oil and ethyl silicon oil.
6. a kind of scar plaster containing nano silicon according to claim 1, it is characterized in that, described Silica hydrogel B component is the polydimethylsiloxane of Methyl Hydrogen Polysiloxane Fluid and vinyl opposite end.
7. the preparation method of a kind of scar plaster containing nano silicon according to any one of claim 1-6, it is characterized in that, preparation method comprises the steps:
S1. collagen protein is dissolved in nanosilica solution, stirs 0.5h ~ 1h to being uniformly dissolved, being prepared into solution E; Again alginate is dissolved in solution E, stirs 1h ~ 2h to dissolving completely, being prepared into gel F;
S2. Silica hydrogel component A is slowly added in Silica hydrogel B component, stir 0.5h ~ 1h to evenly, be prepared into AB component complex;
S3. the AB component complex prepared by S2 adds in vacuum stirring tank, then the gel F prepared by S1 slowly adds in vacuum stirring tank, is-0.8MPa ~ 0.095MPa at pressure, temperature is under 20 ~ 35 DEG C of conditions, stir 4 ~ 7h, and carry out vacuum defoamation, be prepared into product G;
S4. tile one deck silica gel thin film first in a mold, and the product G then prepared by S3 is laid on pellosil, solidifies 6 ~ 10h, finally shear again, namely subpackage, sterilizing obtain a kind of scar plaster containing nano silicon under 50 ~ 70 DEG C of conditions.
8. the preparation method of a kind of scar plaster containing nano silicon according to claim 7, it is characterized in that, the sterilization method in described S4 is irradiation sterilization, and irradiation dose is 15 ~ 25kGy.
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