CN104784104A - Silica gel composition for itching relieving and repairing of scars - Google Patents
Silica gel composition for itching relieving and repairing of scars Download PDFInfo
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- CN104784104A CN104784104A CN201510166435.8A CN201510166435A CN104784104A CN 104784104 A CN104784104 A CN 104784104A CN 201510166435 A CN201510166435 A CN 201510166435A CN 104784104 A CN104784104 A CN 104784104A
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Abstract
Silica gel composition for itching relieving and repairing of scars comprises cross-linked PDMS (polydimethylsiloxane), PDMS, volatile annular siloxane and gaseous-phase silicon dioxide particles and is characterized by further comprising boronized polysiloxane. The silica gel is formed by compositing the cross-linked PDMS, the PDMS, the volatile annular siloxane, a reaction product of boric acid and hydroxy-terminated polydimethylsiloxane, the gaseous-phase silicon dioxide particles and the like. Through adjustment of the ratio of the cross-linked PDMS to the PDMS to the volatile annular siloxane to the reaction product of the boric acid and the hydroxy-terminated polydimethylsiloxane to the gaseous-phase silicon dioxide particles, the water vapor blocking performance, the air permeability, the paintability and the itching relieving performance of the composition are guaranteed.
Description
Technical field
The present invention relates to a kind of for the antipruritic of cicatrix and the Silica hydrogel compositions of repairing.
Background technology
For epigenetic-surface reworking, hypertrophic cicatrix, atrophic scar and keloid.The pathological tissue difference of hypertrophic cicatrix and abnormal scar is thickening of cicatrix deep collagen fiber.Hypertrophy cicatrix shows as protuberate, and profile is irregular, is uneven, and flushing is congested, and matter is real tough.Keloid is the result of collagen fiber hyperplasia in skin injury agglutination, shows as and exceeds normal skin, and shape differs, the benign tumors that the red matter of color is hard.Cicatrix growth exceedes certain limit, various complication can occur, the destruction of such as profile and functional activity obstacle etc., brings huge human body misery and psychic pain to patient.
Research shows, certain humidity and ventilative environment can reduce undue growth [the Quinn K. J. of scar tissue, Evans J.H., Courtney J. M., Gaylor J.D.S., Reid W.H. Non pressure treatment of hypertrophic scars. Burns.1985,12,102 – 108.].Silica hydrogel has good permeability, also has certain steam breathability, can keep the certain moist and ventilative environment of skin area.At present, Silica hydrogel has been widely used in hypertrophy cicatrix and keloidal treatment.Mainly Silica hydrogel cicatrix pad pasting [the Perkins K. of early application; Davey R.B.; Walis A. Silicone gel:A new treatment for burn scars and constracture. Burns. 1983,9 (3), 201; Sun Ping Wei, Liu Chang, Tai rather just, thank to Jiangning, Sun Hui, Shen Jun, Xia Chenglin, yellow Aiwa.Silica hydrogel cicatrix pad pasting prevents and treats the clinical research of hypertrophic cicatrix after wound.Zhenjiang medical college journal, 2000,10 (2), 324-326.]。Silica hydrogel pad pasting can be affixed in affected part, naturally bonds, but joint part or not easily paste smooth place and need to bandage and make it close contact.Attractive in appearance owing to affecting, patient neither feel quite pleased for using Silica hydrogel pad pasting at visible damage position.Silica hydrogel pad pasting to use continuously and to need to reach 12 hours every day, to a certain degree limits movable and work on daytime.Newer product can apply or be sprayed at skin area and the rapid film forming Silica hydrogel of energy at present.This series products can be convenient to use in any position, solves Silica hydrogel pad pasting at joint part or not easily paste smooth place and contact bad problem.And this Silica hydrogel forms very thin one deck on skin, motion and work can not be affected, also can not affect the attractive in appearance of visible damage position.In the market apply or be sprayed at skin area and can rapid film forming Silica hydrogel product based on the Dermatix of the international drugmaker of the Kelo-cote of United States advanced technology company and U.S. Wei Lang.Also there is the product such as DOW CORNING 1544 and DOW CORNING 1688 in Dow corning company.
The serious hypertrophic cicatrix formed after wound healing may cause violent scratching where it itches.Therefore, developing antipruritic agent is the important topic that cicatrix repairs field.Skin pruritus is the modal clinical manifestations of dermatosis such as dermatitis, eczema, urticaria, contact dermatitis, prurigo nodularis, xeroderma, mycotic infection of superficial part, psoriasis and atopic dermatitis simultaneously.[Liao Wanqing, Zhu Yu.The progress of skin pruritus and current treatment status.PLA's medical journal, 2011,36(6), 555-557.] boric acid is medicine very ancient simply, is mainly used in the treatment of acute eczema or acute dermatitis class disease at first.Found that it is apart from outside antibacterial and anti-inflammation functions, still had antivirus action afterwards, its indication greatly increases.In a word, the therapeutic domain of boric acid is very wide, and incidence of side effects is also very low.May be used for small size antipruritic scar medicine.[sorrow continues and sends out, Zhang Chunmei.The application of boric acid in department of dermatologry.1993, 20(5), 47。]
Applying or being sprayed at skin area and can the main component of rapid film forming Silica hydrogel product be crosslinked polydimethylsiloxane, polydimethylsiloxane, aerosil particle, D5 etc. in the market.These products have the antipruritic function of skin area time different.
Summary of the invention
The present invention provides a kind of for the antipruritic of cicatrix and the Silica hydrogel compositions technical problem of repairing to solve.
For solving the problems of the technologies described above, the present invention is a kind of for the antipruritic of cicatrix and the technical solution of the Silica hydrogel compositions of repairing is:
Comprise crosslinked polydimethylsiloxane, polydimethylsiloxane, volatile cyclic silicones and aerosil particle, is characterized in that: also containing boronation polysiloxanes.
As preferably, described crosslinked polydimethylsiloxane accounts for the 20%-45% by weight of described compositions, polydimethylsiloxane accounts for the 1%-10% by weight of described compositions, volatile cyclic silicones accounts for the 35%-60% by weight of described compositions, and boronation polysiloxanes accounts for the 1%-10% by weight of described compositions; Described aerosil particle accounts for the 5%-10% by weight of described compositions.
As preferably, described crosslinked polydimethylsiloxane accounts for the 25%-35% by weight of described compositions.
As preferably, described volatile cyclic silicones is D5, and D5 accounts for the 50%-60% by weight of described compositions.
As preferably, described polydimethylsiloxane viscosity is between 10 cSt-100000 cSt.
As preferably, described polydimethylsiloxane viscosity is between 1000 cSt-12500 cSt.
As preferably, described polydimethylsiloxane accounts for the 2%-5% by weight of described compositions.
As preferably, described boronation polysiloxanes is the product of boric acid and hydroxyl-terminated injecting two methyl siloxane; Described boronation polysiloxanes accounts for the 5%-8% by weight of described compositions.
As preferably, the particle diameter of described aerosil particle is between 4-10 nm.
The technique effect that the present invention can reach is: Silica hydrogel provided by the invention, with polydimethylsiloxane cross-linking agent, polydimethylsiloxane, volatile cyclic silicones, boric acid and hydroxyl-terminated injecting two methyl siloxane product, aerosil particle etc. is composited.By adjustment polydimethylsiloxane cross-linking agent, polydimethylsiloxane, volatile cyclic silicones, boric acid and hydroxyl-terminated injecting two methyl siloxane product, the ratio of aerosil particle, ensures the obstruct steam performance of product simultaneously, permeability, paintability and antipruritic performance.
Accompanying drawing explanation
Below in conjunction with the drawings and specific embodiments, the present invention is further detailed explanation.
Fig. 1 is the schematic diagram of boric acid of the present invention and hydroxyl-terminated injecting two methyl siloxane reaction.
Detailed description of the invention
Below in conjunction with accompanying drawing, elaboration detailed is further done to the present invention.
Consult Fig. 1.
The object of this invention is to provide a kind of boric acid and Silica hydrogel compositions for the antipruritic of cicatrix with repair, thus scratching where it itches of the patient skin avoiding hypertrophic cicatrix etc. to cause, improve therapeutic effect.Reorganization compound can also be used for the antipruritic of other skin sufferer (as chronic eczema).
Silica hydrogel provided by the invention is with polydimethylsiloxane cross-linking agent, polydimethylsiloxane, volatile cyclic silicones, and boric acid and hydroxyl-terminated injecting two methyl siloxane product, aerosil particle etc. is composited.
The crosslinked polydimethylsiloxane cross-linking agent that the present invention uses, polydimethylsiloxane, volatile cyclic silicones, aerosil particle etc. is commercial product.As crosslinked polydimethylsiloxane can be the DOW CORNING TI-3021 SILICONE ELASTOMER BLEND of Dow corning company.Polydimethylsiloxane can Dow corning company there is the DOW CORNING TI-1050 FLUID(10 of different viscosities, 30000,100000 cST).Crosslinked polydimethylsiloxane or the polydimethylsiloxane of high molecular weight is mixed with volatile cyclic silicones can have the spreadability, film property and the skinfeel that keep it.According to the research of Dow Corning company, volatility cyclotetrasiloxane (D4) and D5 (D5) are when absorbing through skin, D4 have be less than 0.5 wt% and D5 have be less than 0.1 wt% absorbed [Marina L. Jovanovic by mouse whole body system, Joan M. McMahon, Debra A. McNett, Joseph M. Tobin, Kathleen P. Plotzke.Regulatory Toxicology and Pharmacology 2008, 50, 239–248]。Preferably by the volatility D5 that skin less absorbs in the present invention, can be the XIAMETER PMX-0245 Cyclopentasiloxane of Dow corning company.Aerosil particle can be used for improving the viscosity of Silica hydrogel, to improve the attachment of skin area and the antifouling property improving Silica hydrogel.Aerosil particle can be the nanometer particle of different size, and on market, supplier is a lot.Preferred particle narrow size distribution, the aerosil particle of particle diameter between 4-10 nm.
Boric acid in the present invention and hydroxyl-terminated injecting two methyl siloxane product are boronation polysiloxanes.Boric acid and hydroxyl-terminated injecting two methyl siloxane react by a certain percentage as shown in Figure 1 under 120 oC, boric acid can react to dewater with hydroxyl-terminated injecting two methyl siloxane and form branched chain structure [the Seetapan N. of more high molecular, Fuongfuchat A., Sirikittikul D., Limparyoon N. Unimodal and bimodal networks of physically crosslinked polyborodimethylsiloxane:viscoelastic and equibiaxial extension behaviors. J. Polym. Res. 2013, 20, 183.].Control the ratio of suitable boric acid and hydroxyl-terminated injecting two methyl siloxane, the hydroxyl having the non-complete reaction of a certain amount of boric acid in boronation polysiloxanes exists, and plays the effect that antiphlogistic antibacterial is antipruritic.This boronation polysiloxanes has higher viscosity, can also be used to the viscosity regulating Silica hydrogel product.
As preferably, described crosslinked polydimethylsiloxane accounts for the 20%-45% by weight of described compositions, polydimethylsiloxane accounts for the 1%-10% by weight of described compositions, volatile cyclic silicones accounts for the 35%-60% by weight of described compositions, and boronation polysiloxanes accounts for the 1%-10% by weight of described compositions; Described aerosil particle accounts for the 5%-10% by weight of described compositions.
As preferably, described crosslinked polydimethylsiloxane accounts for the 25%-35% by weight of described compositions.
As preferably, described volatile cyclic silicones is D5, and D5 accounts for the 50%-60% by weight of described compositions.
As preferably, described polydimethylsiloxane viscosity is between 10 cSt-100000 cSt.
As preferably, described polydimethylsiloxane viscosity is between 1000 cSt-12500 cSt.
As preferably, described polydimethylsiloxane accounts for the 2%-5% by weight of described compositions.
As preferably, described boronation polysiloxanes is the product of boric acid and hydroxyl-terminated injecting two methyl siloxane; Described boronation polysiloxanes accounts for the 5%-8% by weight of described compositions.
By adjustment polydimethylsiloxane cross-linking agent, polydimethylsiloxane, volatile cyclic silicones, boronation polysiloxanes, the ratio of aerosil particle, ensures obstruct steam performance, permeability, paintability and the antipruritic performance of product simultaneously.
Experimental technique in following embodiment, if no special instructions, is conventional method.
First by boric acid and hydroxyl-terminated injecting two methyl siloxane (Sigma-aldrich, 18000-22000 cSt) be after 1:1 at room temperature stirs by the hydroxyl on boric acid and the ratio of the hydroxyl of polydimethylsiloxane, react 2 days at 120 oC, obtain boronation polysiloxanes, for subsequent use after being down to room temperature.
The polydimethylsiloxane (DOW CORNING TI-3021 SILICONE ELASTOMER BLEND) crosslinked by 30 wt%, 50 wt% D5s, 8 wt% boronation polysiloxanes, 7 wt% polydimethylsiloxane (DOW CORNING TI-1050 FLUID, 12500 cST) and 5 wt% aerosil particles (AEROSIL 200) at room temperature stir and obtain compositions.
In embodiment 1, the paintability test comparison sample of compositions is Kelo-cote, and test position is the forearm position participating in tester.Found by contrast test, in embodiment 1, compositions can easily apply, and in embodiment 1, the thickness of the thickness of compositions coat and the gel layer of Kelo-cote product is suitable.
What in embodiment 1, the testing vapor transmission of compositions adopted is moisture vapor transmission cup weight method, and test instrunment is that PERME wins close water vapor permeation rate tester.In embodiment 1, the reference sample of the testing vapor transmission of compositions is collagen film.Method of testing is coated on collagen film by Silica hydrogel compositions in embodiment 1, crosses and within 20 minutes, to allow in compositions after D5 volatilization, measure its water vapor transmittance, then divided by the water vapor transmittance of pure collagen film.In embodiment 1, Silica hydrogel compositions is coated in the water vapor transmittance on collagen film is 60% of the water vapor transmittance of pure collagen film.Illustrate that in embodiment 1, compositions has certain water vapor rejection performance.
That in embodiment 1, the permeability test of compositions adopts is pressure differential method (GB/T 1038-2000), and test instrunment is Jinan blue streak Labthink VAS-VBS air permeability tester.In embodiment 1, the reference sample of the permeability test of compositions is collagen film.Method of testing is coated on collagen film by Silica hydrogel compositions in embodiment 1, crosses and within 20 minutes, to allow in compositions after D5 volatilization, measure its permeability, then divided by the permeability of pure collagen film.In embodiment 1, Silica hydrogel compositions is coated in 67 % that the permeability on collagen film is the permeability of pure collagen film.Illustrate that in embodiment 1, compositions has good permeability.
What in embodiment 1, the evaluation of the treating acne effect of compositions adopted is Hypertrophic rabbit ear scar model.The card punch that the rabbit ear facies ventralis diameter divided in the New Zealand white rabbit of 6 2.5-3 kg is about 1 cm forms a sphere shaped markup, every ear 6 place, and interval is greater than 1 cm, avoids blood vessel, skin and lower perichondrium thereof in excision circle, cartilage-preserving.Wound polyurethane film is covered to healing.Wound on New Zealand white rabbit ear is left intact in contrast (A group).Wound on another ear once, is treated 30 days (B group) with compositions coating in embodiment 1 every day.Put to death white rabbit when the 36th day, cut the holostrome rabbit ear tissue specimen at scar tissue place at cicatrix peak, fixing in formalin, after paraffin embedding, section, serial dehydration, transparent, hematoxylin-eosin staining, carry out histological observation.Cicatrix index (HI) is for cicatrix peak is to distance (s) and the cicatrix periphery normal skin surface on perichondrium surface to the ratio (HI=s/n) of the distance (n) on perichondrium surface.The method that experimental data is checked with t carries out statistical procedures, and p< 0.05 has statistical significance for difference.The average scar hypertrophy index of matched group (A group) is 1.78, and the average scar index for the treatment of group (B group) is 1.18.A, B group is compared, p <0.01.Above data illustrate, in embodiment 1, compositions has the effect significantly suppressing scar hyperplasia.
Claims (9)
1. for the antipruritic of cicatrix and a Silica hydrogel compositions of repairing, comprise crosslinked polydimethylsiloxane, polydimethylsiloxane, volatile cyclic silicones and aerosil particle, is characterized in that: also containing boronation polysiloxanes.
2. according to claim 1 a kind of for the antipruritic of cicatrix and the Silica hydrogel compositions of repairing, it is characterized in that: described crosslinked polydimethylsiloxane accounts for the 20%-45% by weight of described compositions, polydimethylsiloxane accounts for the 1%-10% by weight of described compositions, volatile cyclic silicones accounts for the 35%-60% by weight of described compositions, and boronation polysiloxanes accounts for the 1%-10% by weight of described compositions; Described aerosil particle accounts for the 5%-10% by weight of described compositions.
3. according to claim 2 a kind of for the antipruritic of cicatrix and the Silica hydrogel compositions of repairing, it is characterized in that: described crosslinked polydimethylsiloxane accounts for the 25%-35% by weight of described compositions.
4. according to claim 2 a kind of for the antipruritic of cicatrix and the Silica hydrogel compositions of repairing, it is characterized in that: described volatile cyclic silicones is D5, D5 accounts for the 50%-60% by weight of described compositions.
5. according to claim 2 a kind of for the antipruritic of cicatrix and the Silica hydrogel compositions of repairing, it is characterized in that: described polydimethylsiloxane viscosity is between 10 cSt-100000 cSt.
6. according to claim 2 a kind of for the antipruritic of cicatrix and the Silica hydrogel compositions of repairing, it is characterized in that: described polydimethylsiloxane viscosity is between 1000 cSt-12500 cSt.
7. according to claim 2 a kind of for the antipruritic of cicatrix and the Silica hydrogel compositions of repairing, it is characterized in that: described polydimethylsiloxane accounts for the 2%-5% by weight of described compositions.
8. according to claim 2 a kind of for the antipruritic of cicatrix and the Silica hydrogel compositions of repairing, it is characterized in that: described boronation polysiloxanes is the product of boric acid and hydroxyl-terminated injecting two methyl siloxane; Described boronation polysiloxanes accounts for the 5%-8% by weight of described compositions.
9. according to claim 2 a kind of for the antipruritic of cicatrix and the Silica hydrogel compositions of repairing, it is characterized in that: the particle diameter of described aerosil particle is between 4-10 nm.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105343926A (en) * | 2015-11-09 | 2016-02-24 | 广东泰宝医疗科技股份有限公司 | Scar patch containing nano silicon dioxide and preparation method of scar patch |
| CN105687125A (en) * | 2016-01-29 | 2016-06-22 | 王绿江 | Silica gel for treating skin diseases |
| CN105709266A (en) * | 2015-12-04 | 2016-06-29 | 陕西巨子生物技术有限公司 | Scar-repairing silica gel containing human-like collagen |
| CN110227176A (en) * | 2018-03-05 | 2019-09-13 | 江苏昌吉永生物科技股份有限公司 | Scar eliminating silicone gel dressing and preparation method thereof |
| CN112294753A (en) * | 2020-11-03 | 2021-02-02 | 杭州归领医疗器械有限公司 | Scar gel and its production process |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105343926A (en) * | 2015-11-09 | 2016-02-24 | 广东泰宝医疗科技股份有限公司 | Scar patch containing nano silicon dioxide and preparation method of scar patch |
| CN105343926B (en) * | 2015-11-09 | 2018-12-07 | 广东泰宝医疗科技股份有限公司 | A kind of scar plaster and preparation method thereof containing nano silica |
| CN105709266A (en) * | 2015-12-04 | 2016-06-29 | 陕西巨子生物技术有限公司 | Scar-repairing silica gel containing human-like collagen |
| CN105709266B (en) * | 2015-12-04 | 2018-10-12 | 陕西巨子生物技术有限公司 | A kind of human-like collagen scar reparation Silica hydrogel |
| CN105687125A (en) * | 2016-01-29 | 2016-06-22 | 王绿江 | Silica gel for treating skin diseases |
| CN110227176A (en) * | 2018-03-05 | 2019-09-13 | 江苏昌吉永生物科技股份有限公司 | Scar eliminating silicone gel dressing and preparation method thereof |
| CN112294753A (en) * | 2020-11-03 | 2021-02-02 | 杭州归领医疗器械有限公司 | Scar gel and its production process |
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