CN104814886A - Silicon gel combination - Google Patents
Silicon gel combination Download PDFInfo
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- CN104814886A CN104814886A CN201510166487.5A CN201510166487A CN104814886A CN 104814886 A CN104814886 A CN 104814886A CN 201510166487 A CN201510166487 A CN 201510166487A CN 104814886 A CN104814886 A CN 104814886A
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Abstract
The invention relates to a silicon gel combination, which comprises crosslinked polydimethylsiloxane and polydimethylsiloxane , and the silicon gel combination does not contain volatile annular siloxane. The silicon gel is prepared by compositing the crosslinked polydimethylsiloxane, polydimethylsiloxane and gas phase silica particles. According to the invention, good coating performance of the product can be reached by adjusting the proportion of crosslinked polydimethylsiloxane, polydimethylsiloxane and the gas phase silica particles, so that influence of long-term usage of the volatile annular siloxane on human health can be avoided.
Description
Technical field
The present invention relates to the product for reducing cicatrix and dry skin moisturizing, especially relating to a kind of Silica hydrogel compositions.
Background technology
Cicatrix is the mode of appearance of normal skin tissue caused after various wound and the general designation of tissue pathologies change, is generally divided into epigenetic-surface reworking, hypertrophic cicatrix, atrophic scar and keloid.The pathological tissue difference of hypertrophic cicatrix and abnormal scar is thickening of cicatrix deep collagen fiber.Hypertrophy cicatrix shows as protuberate, and profile is irregular, is uneven, and flushing is congested, and matter is real tough.Keloid is the result of collagen fiber hyperplasia in skin injury agglutination, shows as and exceeds normal skin, and shape differs, the benign tumors that the red matter of color is hard.Cicatrix growth exceedes certain limit, various complication can occur, the destruction of such as profile and functional activity obstacle etc., brings huge human body misery and psychic pain to patient.
Research shows, certain humidity and ventilative environment can reduce undue growth [the Quinn K. J. of scar tissue, Evans J.H., Courtney J. M., Gaylor J.D.S., Reid W.H. Non pressure treatment of hypertrophic scars. Burns.1985,12,102 – 108.].Silica hydrogel has good permeability, also has certain steam breathability, can keep the certain moist and ventilative environment of skin area.At present, Silica hydrogel has been widely used in hypertrophy cicatrix and keloidal treatment.Mainly Silica hydrogel cicatrix pad pasting [the Perkins K. of early application; Davey R.B.; Walis A. Silicone gel:A new treatment for burn scars and constracture. Burns. 1983,9 (3), 201; Sun Ping Wei, Liu Chang, Tai rather just, thank to Jiangning, Sun Hui, Shen Jun, Xia Chenglin, yellow Aiwa.Silica hydrogel cicatrix pad pasting prevents and treats the clinical research of hypertrophic cicatrix after wound.Zhenjiang medical college journal, 2000,10 (2), 324-326.]。Silica hydrogel pad pasting can be affixed in affected part, naturally bonds, but joint part or not easily paste smooth place and need to bandage and make it close contact.Attractive in appearance owing to affecting, patient neither feel quite pleased for using Silica hydrogel pad pasting at visible damage position.Silica hydrogel pad pasting to use continuously and to need to reach 12 hours every day, to a certain degree limits movable and work on daytime.
Newer product can apply or be sprayed at skin area and the rapid film forming Silica hydrogel of energy at present.This series products can be convenient to use in any position, solves Silica hydrogel pad pasting at joint part or not easily paste smooth place and contact bad problem.And this Silica hydrogel forms very thin one deck on skin, motion and work can not be affected, also can not affect the attractive in appearance of visible damage position.In the market apply or be sprayed at skin area and can rapid film forming Silica hydrogel product based on the Dermatix of the international drugmaker of the Kelo-cote of United States advanced technology company and U.S. Wei Lang.Also there is the product such as DOW CORNING 1544 and DOW CORNING 1688 in Dow corning company.Thisly apply or be sprayed at skin area and can also may be used for the moisturizing of dry skin by rapid film forming Silica hydrogel.
The main component of the Silica hydrogel treating acne product that can directly apply or spray at present is crosslinked polydimethylsiloxane, polydimethylsiloxane etc.Crosslinked polydimethylsiloxane or the polydimethylsiloxane of high molecular weight is mixed with volatile siloxane (as D5 etc.) can have better spreadability, film property and skinfeel.D5 is comparatively early for the volatile siloxane of cosmetic formulations, has fabulous spreadability and film property, and can dissolve each other with the natural oils of various skin moistening, can be used for preparing various anhydrous skin care product [Zhao Xunguo.The structure function of silicone compounds used for cosmetic and application (on).Perspective of China Washing Product Industry 2009,4,54-60.].
According to the research of Dow Corning Corporation, for viscosity at 10 to 100, the Dimethicone Crosspolymer of 000 cSt or polydimethylsiloxane, because molecular weight is higher, can not be absorbed by the intestines and stomach and skin, [Andre Colas, Jason Siang, Kathy Ulman. Silicones in Pharmaceutical Applications. Dow Corning Corporation. 2006] is safe from harm to the health of human body.
But for volatile siloxanes, mainly the toxicity of the siloxanes of ring-type exists very to dispute.According to the research of Dow Corning company, suck higher dosage time (700 ppm) octamethylcy-clotetrasiloxane (D4) steam time, the fertility of mouse is caused damage, the ratio suffering from uterus tumor increases [Robert G. Meeks, Donald G. Stump, Waheed H. Siddiqui, Joseph F. Holson, Kathleen P. Plotzke, Vincent L. Reynolds.Reproductive Toxicology 2007，23，192–201 ]。Simultaneously, according to the result of study of Dow Corning company, the decamethylcyclopentaandoxane (D5) of 160ppm is less than at inhalation dose, do not have to find to cause damage [Waheed H. Siddiqui to the fertility of mouse, Donald G. Stump, Vincent L. Reynolds, Kathleen P. Plotzke, Joseph F. Holson, Robert G. Meeks.Reproductive Toxicology 2007,23,216 – 225.]; And when inhalation dose is greater than the decamethylcyclopentaandoxane (D5) of 160ppm, find that mouse suffers from the ratio increase of uterus tumor.[Andre Colas, Jason Siang, Kathy Ulman. Silicones in Pharmaceutical Applications. Dow Corning Corporation. 2006]。
Simultaneously, according to the research of Dow Corning company, D4 and D5 is when absorbing through skin, D4 have be less than 0.5 wt% and D5 have be less than 0.1 wt% absorbed [Marina L. Jovanovic by mouse whole body system, Joan M. McMahon, Debra A. McNett, Joseph M. Tobin, Kathleen P. Plotzke.Regulatory Toxicology and Pharmacology 2008, 50, 239–248]。
Although there is research to point out that the toxicity of D4 and D5 is for mouse, significantly [Andre Colas is not endangered to human body, Jason Siang, Kathy Ulman. Silicones in Pharmaceutical Applications. Dow Corning Corporation. 2006].But, during as cosmetics and physical therapy articles for use life-time service, be still difficult to the impact that eliminating D4 and D5 may cause the health of people.Kelo-cote in the market, contains a certain amount of volatile cyclic silicones in the Silica hydrogel treating acne products such as Dermatix, DOW CORNING 1544 and DOW CORNING 1688.
Summary of the invention
The present invention be exactly in order to solve provide a kind of not containing the Silica hydrogel of volatile cyclic silicones for the treatment of cicatrix and skin moisture-keeping technical problem.
For solving the problems of the technologies described above, the technical solution of a kind of Silica hydrogel compositions of the present invention is:
Comprise crosslinked polydimethylsiloxane, polydimethylsiloxane, described Silica hydrogel compositions is not containing volatile cyclic silicones;
As preferably, described Silica hydrogel compositions also comprises aerosil particle; Described crosslinked polydimethylsiloxane accounts for by weight 55% ~ 85% of described compositions; Described aerosil particle accounts for by weight 5% ~ 20% of described compositions; Described polydimethylsiloxane draws together its viscosity of low viscosity polydimethylsiloxane at 1.5 cSt ~ 10 cSt, also comprises its viscosity of high viscosity polydimethylsiloxane between 50 cSt ~ 100000 cSt; Described low viscosity polydimethylsiloxane accounts for by weight 1% ~ 5% of described compositions; Described high viscosity polydimethylsiloxane accounts for by weight 1% ~ 20% of described compositions.
As preferably, described crosslinked polydimethylsiloxane accounts for by weight 60% ~ 75% of described compositions.
As preferably, described low viscous polydimethylsiloxane viscosity is at 8 cSt ~ 10 cSt, and described full-bodied polydimethylsiloxane viscosity is between 1000 cSt ~ 12500 cSt.
As preferably, the particle diameter of described aerosil particle is between 4 ~ 100 nm.
As preferably, the particle diameter of described aerosil particle is between 4 ~ 60 nm.
As preferably, the particle diameter of described aerosil particle is between 4 ~ 15 nm.
The technique effect that the present invention can reach is: Silica hydrogel provided by the invention, is to be composited with crosslinked polydimethylsiloxane, polydimethylsiloxane, aerosil particle etc.By adjusting crosslinked polydimethylsiloxane, polydimethylsiloxane, the ratio of aerosil particle reaches the good paintability of product, thus avoids life-time service volatile cyclic silicones on the impact of health.
Detailed description of the invention
Elaboration detailed is further done to the present invention below.
Silica hydrogel provided by the invention is be composited with crosslinked polydimethylsiloxane, polydimethylsiloxane, aerosil particle etc., so comprise crosslinked polydimethylsiloxane, polydimethylsiloxane, but not containing volatile cyclic silicones.
Because Silica hydrogel provided by the invention is not containing volatile cyclic silicones, in order to reach good paintability, the polydimethylsiloxane that can be cross-linked by adjustment, polydimethylsiloxane, the ratio of aerosil particle reaches suitable viscosity.When research shows that the Zero shear viscosity (η 0) of Silica hydrogel is 200 Pa about s, under the guarantee obstruct steam of sample and the prerequisite of permeability, still can reach good paintability.
Because Silica hydrogel provided by the invention is not containing volatile cyclic silicones, the Zero shear viscosity (η 0) of Silica hydrogel of the present invention is higher than the Zero shear viscosity (η 0) of the Silica hydrogel treating acne product containing a certain amount of volatile cyclic silicones on market.Can be thicker than the film of the Silica hydrogel treating acne product containing a certain amount of volatile cyclic silicones on market during the coating of this sample product, but the uncomfortable sensations such as pain can not be brought during coating.As preferably, described Silica hydrogel compositions also comprises aerosil particle; Described crosslinked polydimethylsiloxane accounts for by weight 55% ~ 85% of described compositions; Described aerosil particle accounts for by weight 5% ~ 20% of described compositions; Described polydimethylsiloxane draws together its viscosity of low viscosity polydimethylsiloxane at 1.5 cSt ~ 10 cSt, also comprises its viscosity of high viscosity polydimethylsiloxane between 50 cSt ~ 100000 cSt; Described low viscosity polydimethylsiloxane accounts for by weight 1% ~ 5% of described compositions; Described high viscosity polydimethylsiloxane accounts for by weight 1% ~ 20% of described compositions, ensure that water proof vapour, permeability;
As preferably, described crosslinked polydimethylsiloxane accounts for by weight 60% ~ 75% of described compositions.
As preferably, described low viscous polydimethylsiloxane viscosity, at 8 cSt ~ 10 cSt, accounts for by weight 1% ~ 5% of described compositions; Described full-bodied polydimethylsiloxane viscosity is between 1000 cSt ~ 12500 cSt, and account for by weight 1% ~ 20% of described compositions, water proof vapour, permeability are better.
As preferably, the particle diameter of described aerosil particle, between 4 ~ 100 nm, ensure that water proof vapour, permeability and paintability.
As preferably, the particle diameter of described aerosil particle is between 4 ~ 60 nm.
As better preferred, the particle diameter of described aerosil particle is between 4 ~ 15 nm.
The crosslinked polydimethylsiloxane, polydimethylsiloxane, aerosil particle etc. that the present invention uses is commercial product.As crosslinked polydimethylsiloxane can be the DOW CORNING TI-3021 SILICONE ELASTOMER BLEND of Dow corning company.Low viscous polydimethylsiloxane can Dow corning company there is the DOW CORNING TI-1050 FLUID(10 cST of different viscosities).Full-bodied polydimethylsiloxane can Dow corning company there is the DOW CORNING TI-1050 FLUID(12500 of different viscosities, 30000,100000 cST).Aerosil particle can be used for improving the viscosity of Silica hydrogel, to improve the attachment of skin area and the antifouling property improving Silica hydrogel.Aerosil particle can be the nanometer particle of different size, and on market, supplier is a lot.The aerosil particle of preferred particle narrow size distribution.By the ratio of adjustment aerosil particle, crosslinked high viscosity polydimethylsiloxane, polydimethylsiloxane, ensure the obstruct steam of product, permeability, and paintability simultaneously.
Experimental technique in following embodiment, if no special instructions, is conventional method.
The polydimethylsiloxane (DOW CORNING TI-3021 SILICONE ELASTOMER BLEND) crosslinked by 67 wt%, 5 wt% viscosity are polydimethylsiloxane (the DOW CORNING TI-1050 FLUID of 10 cSt, 10 cST), 18 wt% viscosity are that the polydimethylsiloxane (DOW CORNING TI-1050 FLUID, 12500 cST) of 12500 cSt and 10 wt% aerosil particles (AEROSIL 200) at room temperature stir and obtain compositions.
In embodiment 1, the paintability test comparison sample of compositions is the Kelo-cote containing volatility D5, and test position is the forearm position participating in tester.Found by contrast test, in embodiment 1, compositions can easily apply, and during coating, skin area does not have pain perception.Test discovery, in embodiment 1, the thickness of compositions coat is greater than the thickness of the gel layer of Kelo-cote product simultaneously.
What in embodiment 1, the testing vapor transmission of compositions adopted is moisture vapor transmission cup weight method, and test instrunment is that PERME wins close W3/060 water vapor permeation rate tester.In embodiment 1, the reference sample of the testing vapor transmission of compositions is collagen film.Method of testing is coated on collagen film by Silica hydrogel compositions in embodiment 1, measures its water vapor transmittance, then divided by the water vapor transmittance of pure collagen film.In embodiment 1, the Silica hydrogel compositions water vapor transmittance be coated on collagen film only has 65% of the water vapor transmittance of pure collagen film.Illustrate that in embodiment 1, compositions has certain water vapor rejection performance.
That in embodiment 1, the permeability test of compositions adopts is pressure differential method (GB/T 1038-2000), and test instrunment is Jinan blue streak Labthink VAS-VBS air permeability tester.In embodiment 1, the reference sample of the permeability test of compositions is collagen film.Method of testing is coated on collagen film by Silica hydrogel compositions in embodiment 1, measures its permeability, then divided by the permeability of pure collagen film.In embodiment 1, Silica hydrogel compositions is coated in the permeability on collagen film is 85% of the water vapor transmittance of pure collagen film.Illustrate that in embodiment 1, compositions has good permeability.
What in embodiment 1, the evaluation of the treating acne effect of compositions adopted is Hypertrophic rabbit ear scar model.The card punch that the rabbit ear facies ventralis diameter divided in the New Zealand white rabbit of 6 2.5-3 kg is about 1 cm forms a sphere shaped markup, every ear 6 place, and interval is greater than 1 cm, avoids blood vessel, skin and lower perichondrium thereof in excision circle, cartilage-preserving.Wound polyurethane film is covered to healing.Wound on New Zealand white rabbit ear is left intact in contrast (A group).Wound on another ear once, is treated 30 days (B group) with compositions coating in embodiment 1 every day.Put to death white rabbit when the 36th day, cut the holostrome rabbit ear tissue specimen at scar tissue place at cicatrix peak, fixing in formalin, after paraffin embedding, section, serial dehydration, transparent, hematoxylin-eosin staining, carry out histological observation.Cicatrix index (HI) is for cicatrix peak is to distance (s) and the cicatrix periphery normal skin surface on perichondrium surface to the ratio (HI=s/n) of the distance (n) on perichondrium surface.The method that experimental data is checked with t carries out statistical procedures, and p< 0.05 has statistical significance for difference.The average scar hypertrophy index of matched group (A group) is 1.88, and the average scar index for the treatment of group (B group) is 1.25.A, B group is compared, p <0.01.Above data illustrate, in embodiment 1, compositions has the effect significantly suppressing scar hyperplasia.
Claims (7)
1. a Silica hydrogel compositions, comprises crosslinked polydimethylsiloxane, polydimethylsiloxane, it is characterized in that: described Silica hydrogel compositions is not containing volatile cyclic silicones.
2. a kind of Silica hydrogel compositions according to claim 1, is characterized in that: described Silica hydrogel compositions also comprises aerosil particle; Described crosslinked polydimethylsiloxane accounts for by weight 55% ~ 85% of described compositions; Described aerosil particle accounts for by weight 5% ~ 20% of described compositions; Described polydimethylsiloxane draws together its viscosity of low viscosity polydimethylsiloxane at 1.5 cSt ~ 10 cSt, also comprises its viscosity of high viscosity polydimethylsiloxane between 50 cSt ~ 100000 cSt; Described low viscosity polydimethylsiloxane accounts for by weight 1% ~ 5% of described compositions; Described high viscosity polydimethylsiloxane accounts for by weight 1% ~ 20% of described compositions.
3. a kind of Silica hydrogel compositions according to claim 2, is characterized in that: described crosslinked polydimethylsiloxane accounts for by weight 60% ~ 75% of described compositions.
4. a kind of Silica hydrogel compositions according to claim 2, is characterized in that: described low viscous polydimethylsiloxane viscosity is at 8 cSt ~ 10 cSt; Described full-bodied polydimethylsiloxane viscosity is between 1000 cSt ~ 12500 cSt.
5. a kind of Silica hydrogel compositions according to claim 2, is characterized in that: the particle diameter of described aerosil particle is between 4 ~ 100 nm.
6. a kind of Silica hydrogel compositions according to claim 5, is characterized in that: the particle diameter of described aerosil particle is between 4 ~ 60 nm.
7. a kind of Silica hydrogel compositions according to claim 6, is characterized in that: the particle diameter of described aerosil particle is between 4 ~ 15 nm.
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| CN201510166487.5A CN104814886A (en) | 2015-04-10 | 2015-04-10 | Silicon gel combination |
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Cited By (2)
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| CN105012228A (en) * | 2015-08-17 | 2015-11-04 | 郑州和济生物科技股份有限公司 | Hyaluronic acid and silica gel composition for scar prevention and early repair and preparation method of hyaluronic acid and silica gel composition |
| CN113347982A (en) * | 2018-11-05 | 2021-09-03 | 因斯拜尔材料配方有限责任公司 | Dermal skin protectant and carrier |
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| CN1668345A (en) * | 2002-07-16 | 2005-09-14 | 先进生物技术公司 | Wound dressing |
| CN101742979A (en) * | 2007-03-08 | 2010-06-16 | 科锐医疗有限公司 | Dressing formulations to prevent and reduce scarring |
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| CN105012228A (en) * | 2015-08-17 | 2015-11-04 | 郑州和济生物科技股份有限公司 | Hyaluronic acid and silica gel composition for scar prevention and early repair and preparation method of hyaluronic acid and silica gel composition |
| CN105012228B (en) * | 2015-08-17 | 2018-04-20 | 郑州和济生物科技股份有限公司 | Prevent the sodium hyaluronate Silica hydrogel composition and preparation method of scar formation and Complicated primary |
| CN113347982A (en) * | 2018-11-05 | 2021-09-03 | 因斯拜尔材料配方有限责任公司 | Dermal skin protectant and carrier |
| EP3876949A4 (en) * | 2018-11-05 | 2022-08-10 | Inspired Material Solutions, LLC | Dermal skin protectant and carrier |
| US11690916B2 (en) | 2018-11-05 | 2023-07-04 | Inspired Material Solutions, LLC | Dermal skin protectant and carrier |
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Application publication date: 20150805 |