EA022847B1 - Disinfectant and antiseptic formulation having reduced iodine content - Google Patents

Disinfectant and antiseptic formulation having reduced iodine content Download PDF

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Publication number
EA022847B1
EA022847B1 EA201390090A EA201390090A EA022847B1 EA 022847 B1 EA022847 B1 EA 022847B1 EA 201390090 A EA201390090 A EA 201390090A EA 201390090 A EA201390090 A EA 201390090A EA 022847 B1 EA022847 B1 EA 022847B1
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mixture
elemental iodine
siloxane
drug
solvent
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EA201390090A
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Russian (ru)
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EA201390090A1 (en
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Эндре Микулашик
Тамаш Шпаитш
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Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг
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Publication of EA201390090A1 publication Critical patent/EA201390090A1/en
Publication of EA022847B1 publication Critical patent/EA022847B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/12—Iodine, e.g. iodophors; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/18—Iodine; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A61K8/585—Organosilicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cleaning By Liquid Or Steam (AREA)

Abstract

The invention is related to the use of the solution of elemental iodine prepared in an organosiloxane solvent as antiseptic or disinfectant agent and formulations suitable for such use.

Description

(57) Изобретение относится к применению раствора элементного йода, приготовленного в органосилоксановом растворителе, в качестве антисептического или дезинфицирующего средства и к препаратам, пригодным для такого применения.(57) The invention relates to the use of a solution of elemental iodine prepared in an organosiloxane solvent as an antiseptic or disinfectant, and to preparations suitable for such use.

022847 Β1022847 Β1

Настоящее изобретение относится к дезинфицирующему и антисептическому препарату, имеющему сниженное содержание йода, проявляющему отличную тканевую совместимость. Препарат в соответствии с настоящим изобретением содержит йод в элементной форме вероятнее, чем в ионной или комплексной форме. Следующий объект настоящего изобретения составляет способ получения дезинфицирующего и антисептического препарата в соответствии с изобретением. Еще один объект настоящего изобретения представляет собой применение раствора йода, полученного с силоксановым растворителем, в качестве дезинфицирующего и антисептического средства.The present invention relates to a disinfectant and antiseptic preparation having a reduced iodine content, exhibiting excellent tissue compatibility. The preparation in accordance with the present invention contains iodine in elemental form more likely than in ionic or complex form. The next object of the present invention is a method for producing a disinfectant and antiseptic preparation in accordance with the invention. Another object of the present invention is the use of a solution of iodine obtained with a siloxane solvent as a disinfectant and antiseptic.

Предшествующий уровень техникиState of the art

Claims (14)

1. Применение раствора элементного йода, приготовленного с органическим растворителем силоксанового типа, в качестве дезинфицирующего или антисептического средства для обработки повреждений кожи животных или человека, причем (1) растворитель включает летучий силоксан или смесь летучих силоксанов, и (2) концентрация элементного йода в растворе составляет 0,001-0,8 мас.%.1. The use of a solution of elemental iodine prepared with a siloxane type organic solvent as a disinfectant or antiseptic for treating skin lesions of animals or humans, wherein (1) the solvent includes volatile siloxane or a mixture of volatile siloxanes, and (2) the concentration of elemental iodine in the solution is 0.001-0.8 wt.%. 2. Применение раствора элементного йода, приготовленного с органическим растворителем силоксанового типа, для получения дезинфицирующих или антисептических фармацевтических препаратов,2. The use of a solution of elemental iodine prepared with an organic solvent of a siloxane type to obtain disinfectant or antiseptic pharmaceuticals, - 6 022847 причем (1) растворитель включает летучий силоксан или смесь летучих силоксанов, и (2) концентрация элементного йода в растворе составляет 0,001-0,8 мас.%.- 6 022847 wherein (1) the solvent includes volatile siloxane or a mixture of volatile siloxanes, and (2) the concentration of elemental iodine in the solution is 0.001-0.8 wt.%. 3. Применение по п.1 или 2, где растворитель представляет собой гексаметилдисилоксан, октаметилтрисилоксан, декаметилциклопентасилоксан или их смесь.3. The use according to claim 1 or 2, where the solvent is hexamethyldisiloxane, octamethyltrisiloxane, decamethylcyclopentasiloxane, or a mixture thereof. 4. Применение по п.1, характеризующееся тем, что концентрация элементного йода в его растворе, приготовленном с растворителем силоксанового типа, составляет 0,1-0,5 мас.%.4. The use according to claim 1, characterized in that the concentration of elemental iodine in its solution prepared with a siloxane type solvent is 0.1-0.5 wt.%. 5. Дезинфицирующий или антисептический фармацевтический препарат, содержащий элементный йод в качестве активного агента и силоксан или смесь силоксанов в качестве растворителя, причем (1) растворитель включает летучий силоксан или смесь летучих силоксанов, и (2) концентрация элементного йода в препарате составляет 0,001-0,8 мас.%.5. A disinfectant or antiseptic pharmaceutical preparation containing elemental iodine as an active agent and a siloxane or a mixture of siloxanes as a solvent, wherein (1) the solvent includes volatile siloxane or a mixture of volatile siloxanes, and (2) the concentration of elemental iodine in the preparation is 0.001-0 , 8 wt.%. 6. Препарат по п.5, характеризующийся тем, что растворитель дополнительно включает силиконовое масло или силиконовый эластомер, либо их смесь.6. The drug according to claim 5, characterized in that the solvent further includes silicone oil or silicone elastomer, or a mixture thereof. 7. Препарат по п.5 или 6, характеризующийся тем, что концентрация элементного йода в препарате составляет 0,1-0,5 мас.%.7. The drug according to claim 5 or 6, characterized in that the concentration of elemental iodine in the drug is 0.1-0.5 wt.%. 8. Препарат по п.5 или 6, характеризующийся тем, что силоксановый растворитель представляет собой гексаметилдисилоксан, октаметилтрисилоксан, декаметилциклопентасилоксан или их смесь.8. The drug according to claim 5 or 6, characterized in that the siloxane solvent is hexamethyldisiloxane, octamethyltrisiloxane, decamethylcyclopentasiloxane or a mixture thereof. 9. Препарат по п.5 или 6 в форме аэрозоля, раствора, геля, настойки, крема или пены.9. The drug according to claim 5 or 6 in the form of an aerosol, solution, gel, tincture, cream or foam. 10. Препарат по п.5 или 6, характеризующийся тем, что препарат содержит дополнительные эксципиенты.10. The drug according to claim 5 or 6, characterized in that the drug contains additional excipients. 11. Препарат по п.10, содержащий диметикон.11. The drug of claim 10, containing dimethicone. 12. Препарат по п.5 или 6, характеризующийся тем, что препарат содержит дополнительные фармацевтически активные ингредиенты.12. The drug according to claim 5 or 6, characterized in that the drug contains additional pharmaceutically active ingredients. 13. Препарат по п.5 или 6, содержащий дополнительный антисептический или дезинфицирующий агент, антибиотик, косметический агент, пригодный для обработки здоровой или поврежденной кожи, агент, регенерирующий ткань, или агент, способствующий заживлению раны.13. The drug according to claim 5 or 6, containing an additional antiseptic or disinfectant agent, an antibiotic, a cosmetic agent suitable for treating healthy or damaged skin, a tissue regenerating agent, or an agent that promotes wound healing. 14. Способ получения препаратов по п.5 или 6, который включает диспергирование или растворение элементного йода в летучем силоксане или смеси летучих силоксанов, причем если в препарате используют смесь силоксанов, элементный йод диспергируют или растворяют сначала в силоксановом компоненте самой низкой молекулярной массы, используемом в препарате.14. The method of producing preparations according to claim 5 or 6, which comprises dispersing or dissolving elemental iodine in volatile siloxane or a mixture of volatile siloxanes, wherein if a mixture of siloxanes is used in the preparation, elemental iodine is dispersed or dissolved first in the siloxane component of the lowest molecular weight used in the drug.
EA201390090A 2010-07-12 2011-07-12 Disinfectant and antiseptic formulation having reduced iodine content EA022847B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU1000362A HUP1000362A2 (en) 2010-07-12 2010-07-12 Antiseptic and disinfecting compositions having reduced iodine content
PCT/HU2011/000065 WO2012007776A2 (en) 2010-07-12 2011-07-12 Disinfectant and antiseptic formulation having reduced iodine content

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EA201390090A1 EA201390090A1 (en) 2013-05-30
EA022847B1 true EA022847B1 (en) 2016-03-31

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EP (1) EP2592935A2 (en)
AR (1) AR082155A1 (en)
BR (1) BR112013000690A2 (en)
EA (1) EA022847B1 (en)
GE (1) GEP20156236B (en)
HK (1) HK1150373A2 (en)
HU (1) HUP1000362A2 (en)
TW (1) TW201216859A (en)
UA (1) UA109144C2 (en)
UY (1) UY33502A (en)
WO (1) WO2012007776A2 (en)

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CA2990627A1 (en) 2015-06-22 2016-12-29 Infection Containment Company, LLC Topical antiseptic system
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CN112755050B (en) * 2020-12-31 2022-11-15 佛山市正典生物技术有限公司 Alcohol-free iodine-containing disinfectant with high component stability and preparation method thereof
CN114208818B (en) * 2021-11-09 2022-10-04 佛山市正典生物技术有限公司 Iodine-containing disinfectant containing polyol ether and/or cyclic ether and preparation method thereof

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UY33502A (en) 2012-01-31
HK1150373A2 (en) 2011-12-16
EP2592935A2 (en) 2013-05-22
WO2012007776A2 (en) 2012-01-19
BR112013000690A2 (en) 2016-05-17
AR082155A1 (en) 2012-11-14
HUP1000362A2 (en) 2012-11-28
HU1000362D0 (en) 2010-10-28
UA109144C2 (en) 2015-07-27
GEP20156236B (en) 2015-01-26
EA201390090A1 (en) 2013-05-30
WO2012007776A3 (en) 2012-06-07
TW201216859A (en) 2012-05-01

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