CN103191459A - Composite silica gel protective dressing and preparation method thereof - Google Patents
Composite silica gel protective dressing and preparation method thereof Download PDFInfo
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- CN103191459A CN103191459A CN2013101151127A CN201310115112A CN103191459A CN 103191459 A CN103191459 A CN 103191459A CN 2013101151127 A CN2013101151127 A CN 2013101151127A CN 201310115112 A CN201310115112 A CN 201310115112A CN 103191459 A CN103191459 A CN 103191459A
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Abstract
The invention relates to medical composite silica gel protective dressing and a preparation method thereof. The method comprises the concrete steps of 1) adding lysine and tea polyphenol to deionized water to dissolve according to a certain ratio, evenly agitating to prepare mixed solution of lysine and tea polyphenol; 2) adding silica sol to the mixed solution of lysine and tea polyphenol; 3) adding a certain amount of surfactant to the mixed solution of lysine and tea polyphenol to evenly mix, thereby obtaining the composite silica gel; and 4) centrifuging and dewatering the composite silica gel, and thoroughly cleaning a filter cake by the deionized water, and crushing to obtain the composite silica gel powder, adding the powder to distilled water of which the mass ratio to the powder is 1.5 to 1, and evenly heating and mixing at the temperature of 40-60 DEG C to obtain the composite silica gel protective dressing under an agitation state, and preparing the composite silica gel protective dressing into a patch according to a common technology. The prepared protective dressing can effectively prevent bacterium and sterilize the wound surface, so as to relieve itching of the wound surface when effectively preventing and treating various scars after operations, trauma and burn. Thus, use of a receptor is greatly facilitated.
Description
Technical field
The present invention relates to a kind of medical comprehensive silicon gel and protect wound dressing and preparation method thereof, particularly a kind of have the promoted wound healing of anti-inflammation function and remove silicon gel of scar function and preparation method thereof.
Background technology
Significantly skin wound as damage or the caused wound of performing the operation, often causes cicatrization.Cicatrix causes sense of touch to reduce under many circumstances, flexible forfeiture and range of movement forfeiture.Particularly when facial and on hand the time, cicatrization also causes tangible aesthetic problem.Skin wound also is easy to infect, and namely uses conventional dressing, infects also quite general.The fire victim is infected especially easily, and may leave serious cicatrization when wound healing.Method to the treatment skin injury that minimizes or eliminate cicatrization is sought in demand.
At present on the market except the scar product a lot, wherein to be 201010563028.8 patent disclosure a kind of protects the preparation technology that wound is applied ointment or plaster for application number, thisly protect the form that wound applies ointment or plaster mainly with hydrogel and exist, its composition mainly comprises chitosan, Oligomeric maltose, Oleum menthae, P-hydroxybenzoic acid, glycerol, polyvinylpyrrolidone and polyacrylic acid and water are formed.Application number a kind of curable silicon gel combination that has been 201110187629.8 patent disclosure, the main component of said composition comprises organopolysiloxane, organic hydrogen polysiloxanes, platinum-catalyst based.The patent No. be ZL 200410096766.0 patent disclosure a kind of preparation method of silicon gel carrying silver ion, this method mainly joins Ludox in the silver nitrate solution that contains surfactant, obtains silicon gel carrying silver ion.It is a kind of for wound healing with reduce the compositions based on the silicon gel of cicatrix that application number is 200880109515.8 international patent publications, and said composition mainly comprises annular siloxane, siloxanes confining liquid, siloxanes sealing gel and silicone resin powder.
Can draw the silicon gel-like from above patented technology and account for leading position except the scar product at wound healing with except the scar product.Yet the silicate gel film of preventing and treating scar hyperplasia at present uses after being the wound healing cicatrization, is not suitable in the art and the use of wound healing phase, and it is used for the treatment of the cicatrix that already forms, and effect is not good enough.
Along with to wound healing and except the physiopathologic further investigation of scar process, people to wound healing and except the understanding of scar process also more and more deep, thereby make medical Wound dressing update and develop.Be incorporated in the silicon gel though present technical research has had silver ion etc. the metal ion of antibacterial functions, increasing the antibacterial functions except the scar product, but the prepared product cost of this method is higher, for enterprise and patient bring bigger economic pressures.
Lysine is the seed amino acid that human body needs, a kind of indispensable nutrient substance has and can improve intelligence, promotes growth, health invigorating, appetite stimulator, improves the malnutrition situation, improve insomnia, improve memory, help to produce antibody, hormone and enzyme, improve immunity, increase hematochrome, help the absorption of calcium, treatment prevents osteoporosis, reduces the level of triglyceride in the blood, the generation of prevention cardiovascular and cerebrovascular disease.Tea polyphenols itself has very strong anti-oxidation function and antibacterial functions, its oxidation resistance is synthetic antioxidant BHT and BHA 4-6 times, be the 6-7 of VE doubly, and consumption is few, the potential toxic and side effects of no synthetic, so be introduced into the effect that both can reach the antibiotic property that strengthens silicon gel itself in the silicon gel, antiinflammatory and the pot-life that can improve product again.But before the present invention, nobody sets forth or recognizes that lysine and tea polyphenols have great potential aspect wound, and can become the powerful mean of resisting antibacterial existence and growth, and that the existence of antibacterial and growth are traumatic infections is the most common the most fatal, and nobody recognizes that can produce suitable Wound care infects the most common the most fatal, and nobody recognizes and can produce suitable wound care products to realize this purpose, compare with the toxic metal ion with the application disinfectant, do not exist when realizing purpose to make bacterial antibiotic produce multidrug resistant danger, perhaps do not exist organizing hurtful danger.
Summary of the invention
Technical problem to be solved by this invention provides a kind of promoted wound healing with anti-inflammation function and except comprehensive silicon gel of scar function and preparation method thereof, this method mainly is that lysine and the tea polyphenols that will have the anti-inflammation function are incorporated in the silicon gel, the method for preparing a kind of medical comprehensive silicon gel, this technology is simple, cost is low, with short production cycle, can produce in enormous quantities.
The present invention solves above technical problem with following technical scheme:
1) lysine and tea polyphenols are joined in the deionized water by a certain percentage dissolve, stirring is prepared into lysine and tea polyphenols mixed solution;
2) Ludox is joined in the mixed solution of lysine and tea polyphenols;
3) add certain amount of surfactant in the mixed solution of Ludox and lysine and tea polyphenols and make its mix homogeneously, obtain the comprehensive silicon gel;
4) thoroughly clean filter cake with the centrifuge dehydration of comprehensive silicon gel, and with deionized water, pulverize again, obtain comprehensive silicon gel powder body.With adding in this powder body with powder quality than being in the distilled water of 1.5 ﹕ 1, under 40～60 ℃ of temperature of stirring, heat mix homogeneously and obtain the silicon gel dressing.
The present invention, described comprehensive silicon gel protects wound dressing, can be by the preparation of following method: 5～100g lysine and 2～30g tea polyphenols joined in the 1kg deionized water dissolve, stir, make lysine and tea polyphenols mixed solution, under stirring, in described mixed solution, add Ludox 200mL, after being dissolved in 0.001～0.003g surfactant in the 10mL deionized water, join in the mixed solution of Ludox and lysine and tea polyphenols, make Ludox and lysine and tea polyphenols mix homogeneously, obtain the comprehensive silicon gel, centrifuge dehydration then, and thoroughly clean filter cake with deionized water, pulverize again, obtain comprehensive silicon gel powder body, will add in this powder body with powder quality than being in the distilled water of 1.5 ﹕ 1, under 40～60 ℃ of temperature of stirring, heat mix homogeneously and obtain the silicon gel and protect wound dressing.
The present invention, described surfactant is cationic surfactant polyacrylamide, zwitterionic surfactant hexadecyldimethyl benzyl ammonium amine second lactone or anion surfactant dodecyl sodium sulfate.
The present invention, with described silicon gel dressing routinely technology prepare patch---medical silicon gel cicatrix pastes, the ultimate principle that is used for prevention and treatment hypertrophic cicatrix is: the micromolecule silicone oil of silicon gel is penetrated into the cicatrix position, form hydrated collagen with collagen protein, make the deliquescing of cicatrix position, color is thin out.Rely on paster to the pressure of skin simultaneously, the undue growth of blocking-up collagen fiber prevents hypertrophic cicatrix.Therefore, the key factor of cicatrix subsides prevention and treatment hypertrophic cicatrix is micromolecule silicone oil and pressure.
The present invention, with the silicon gel as carrier, after lysine introduced the silicon gel, its anti-microbial property increases, this mainly be because, after in the silicon gel, introducing lysine, can increase the amino density of silicon gel surface, so increase the positive charge density of silicon gel surface, thereby increase the cohesion of its antibacterial that wound surface is existed with the negative charge form, stick when wound surface, be adsorbed in the wound surface surface, wound surface and extraneous antibacterial are isolated, thereby stop the pathogenic bacteria field planting, promote blood coagulation, thereby accelerate the reparation of wound surface.
The present invention, employed tea polyphenols is natural strong oxidizer, can effectively remove the unnecessary oxygen-derived free radicals that produces in the skin, suppresses to cause scorching bacterium and pro-inflammatory cytokine in the skin, and scytitis is had good therapeutical effect.
The present invention, comprehensive silicon gel prepared therefrom is except the scar product, it is single and introduce heavy metal ion and increase the user skin damage easily to have overcome in the prior art product function, the defective of heavy metal poisoning and drug anaphylaxis, wound is applied ointment or plaster after effectively preventing and treat operation, wound and burn in all kinds of cicatrixes, wound surface is carried out effectively antibiotic, sterilization, make wound surface antipruritic, greatly make things convenient for the receptor to use.
The specific embodiment
Embodiment 1: 5g lysine and 2g tea polyphenols are joined in the 1kg deionized water dissolve, stir, make lysine and tea polyphenols mixed solution, under stirring, in above mixed solution, add Ludox 200mL, after being dissolved in 0.001g cationic surfactant polyacrylamide in the 10mL deionized water, join in the mixed solution of Ludox and lysine and tea polyphenols, make Ludox and lysine and tea polyphenols mix homogeneously, obtain the comprehensive silicon gel, centrifuge dehydration then, and thoroughly clean filter cake with deionized water, pulverize again, obtain comprehensive silicon gel powder body, will add in this powder body with powder quality than being in the distilled water of 1.5 ﹕ 1, under 40 ℃ of temperature of stirring, heat mix homogeneously and obtain the comprehensive silicon gel and protect wound dressing.With this comprehensive silicon gel protect wound dressing routinely technology make patch, it is on probation to be used for the patient that wound surface heals about 1 week of back fully.Earlier with warm water the affected part is cleaned gently and is wiped away during use dried, the attached affected part that is affixed on of silicon gel pad pasting is bonding naturally, used continuously every day 12 hours.The most of sufferings symptom of this patient is eased after 1 week.Further consultation joint part cicatrix softness after two months, function effect little (judge obviously be better than without the pad pasting person from clinical experience), and be reduced to 6.0mm by the thickness that the 10MHZ B ultrasonic detects cicatrix by original 6.8mm.
Embodiment 2: 100g lysine and 30g tea polyphenols are joined in the 1kg deionized water dissolve, make lysine and tea polyphenols mixed solution, and under stirring, in above mixed solution, add Ludox 200mL, after being dissolved in 0.003g zwitterionic surfactant hexadecyldimethyl benzyl ammonium amine second lactone in the 10mL deionized water, join in the mixed solution of Ludox and lysine and tea polyphenols, make Ludox and lysine and tea polyphenols mix homogeneously, obtain the comprehensive silicon gel, centrifuge dehydration then, and thoroughly clean filter cake with deionized water, pulverize again, obtain comprehensive silicon gel powder body, to add in this powder body with powder quality than being in the distilled water of 1.5 ﹕ 1, under 60 ℃ of temperature of stirring, heat mix homogeneously and obtain the comprehensive silicon gel and protect wound dressing.With this comprehensive silicon gel protect wound dressing routinely technology make patch, it is on probation to be used for the patient that wound surface heals about 1 week of back fully.Earlier with warm water the affected part is cleaned gently and is wiped away during use dried, the attached affected part that is affixed on of silicon gel pad pasting is bonding naturally, used continuously every day 12 hours.The most of sufferings symptom of this patient is eased after 1 week.Further consultation joint part cicatrix softness after two months, function effect little (judge obviously be better than without the pad pasting person from clinical experience), and be reduced to 3.5mm by the thickness that the 10MHZ B ultrasonic detects cicatrix by original 4.9mm.
Embodiment 3: 50g lysine and 15g tea polyphenols are joined in the 1kg deionized water dissolve, make lysine, the tea polyphenols mixed solution, and under stirring, in above mixed solution, add Ludox 200mL, after being dissolved in 0.003g anion surfactant dodecyl sodium sulfate in the 10mL deionized water, join in the mixed solution of Ludox and lysine and tea polyphenols, make Ludox and lysine and tea polyphenols mix homogeneously, obtain the comprehensive silicon gel, centrifuge dehydration then, and thoroughly clean filter cake with deionized water, pulverize again, obtain comprehensive silicon gel powder body.To add in this powder body with powder quality than being in the distilled water of 1.5 ﹕ 1, under 50 ℃ of temperature of stirring, heat mix homogeneously and obtain the comprehensive silicon gel and protect wound dressing.With this comprehensive silicon gel protect wound dressing routinely technology make patch, it is on probation to be used for the patient that wound surface heals about 1 week of back fully.Earlier with warm water the affected part is cleaned gently and is wiped away during use dried, the attached affected part that is affixed on of silicon gel pad pasting is bonding naturally, used continuously every day 12 hours.The most of sufferings symptom of this patient is eased after 1 week.Further consultation joint part cicatrix softness after two months, function effect little (judge obviously be better than without the pad pasting person from clinical experience), and be reduced to 5.2mm by the thickness that the 10MHZ B ultrasonic detects cicatrix by original 5.4mm.
Claims (3)
1. the preparation method that the comprehensive silicon gel protects wound dressing is characterized in that, comprises following processing step:
1) lysine and tea polyphenols are joined in the deionized water by a certain percentage dissolves, stir and make lysine and tea polyphenols mixed solution;
2) Ludox is joined in the mixed solution of lysine and tea polyphenols;
3) add certain amount of surfactant in the mixed solution of Ludox and lysine and tea polyphenols and make its mix homogeneously, obtain the comprehensive silicon gel;
4) with the centrifuge dehydration of comprehensive silicon gel, and thoroughly clean filter cake with deionized water, and pulverize again, obtain comprehensive silicon gel powder body, to add in this powder body with powder quality than being in the distilled water of 1.5 ﹕ 1, under 40～60 ℃ of temperature of stirring, heat mix homogeneously and obtain the silicon gel and protect wound dressing.
2. a comprehensive silicon gel protects wound dressing, by the preparation of following method: 5～100g lysine and 2～30g tea polyphenols joined in the 1kg deionized water dissolve, stir, make lysine and tea polyphenols mixed solution, under stirring, in described mixed solution, add Ludox 200mL, after being dissolved in 0.001～0.003g surfactant in the 10mL deionized water, join in the mixed solution of Ludox and lysine and tea polyphenols, make Ludox and lysine and tea polyphenols mix homogeneously, obtain the comprehensive silicon gel, centrifuge dehydration then, and thoroughly clean filter cake with deionized water, and pulverize again, obtain comprehensive silicon gel powder body, to add in this powder body with powder quality than being in the distilled water of 1.5 ﹕ 1, under 40～60 ℃ of temperature of stirring, heat mix homogeneously and obtain the silicon gel and protect wound dressing.
3. comprehensive silicon gel according to claim 2 protects wound dressing, it is characterized in that described surfactant is cationic surfactant polyacrylamide, zwitterionic surfactant hexadecyldimethyl benzyl ammonium amine second lactone or anion surfactant dodecyl sodium sulfate.
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| CN201310115112.7A CN103191459B (en) | 2013-04-06 | 2013-04-06 | Composite silica gel protective dressing and preparation method thereof |
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| CN201310115112.7A CN103191459B (en) | 2013-04-06 | 2013-04-06 | Composite silica gel protective dressing and preparation method thereof |
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Cited By (8)
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|---|---|---|---|---|
| CN103550828A (en) * | 2013-10-17 | 2014-02-05 | 中国科学院动物研究所 | Skin renewal method based on hair follicle stem cells and silica gel dressing |
| CN104436290A (en) * | 2014-11-07 | 2015-03-25 | 广东泰宝医疗科技股份有限公司 | Functional dressing for inhibiting scar hyperplasia and preparation method thereof |
| CN104814886A (en) * | 2015-04-10 | 2015-08-05 | 浙江省诸暨市珠力神医用品有限公司 | Silicon gel combination |
| CN107296975A (en) * | 2017-08-03 | 2017-10-27 | 江苏亿茂滤材有限公司 | A kind of antibacterial anti hemorrhagic based composite dressing for medical use and preparation method thereof |
| WO2020077923A1 (en) * | 2018-10-19 | 2020-04-23 | 中山大学 | Polypropylene/tea polyphenol patch for intraperitoneal repair, preparation method therefor and use thereof |
| CN111298199A (en) * | 2020-04-13 | 2020-06-19 | 虞连奎 | Temporary implant for orthopedics department and preparation method thereof |
| CN113332488A (en) * | 2021-05-31 | 2021-09-03 | 南昌智产科技有限公司 | Medical silica gel foam dressing and preparation method thereof |
| CN116019963A (en) * | 2022-12-02 | 2023-04-28 | 江苏弘生生物工程有限公司 | Preparation method of medical silica gel foam dressing |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550828A (en) * | 2013-10-17 | 2014-02-05 | 中国科学院动物研究所 | Skin renewal method based on hair follicle stem cells and silica gel dressing |
| CN103550828B (en) * | 2013-10-17 | 2016-01-27 | 中国科学院动物研究所 | A kind of skin renewal method based on hair follicle stem cells and Silica hydrogel dressing |
| CN104436290A (en) * | 2014-11-07 | 2015-03-25 | 广东泰宝医疗科技股份有限公司 | Functional dressing for inhibiting scar hyperplasia and preparation method thereof |
| CN104814886A (en) * | 2015-04-10 | 2015-08-05 | 浙江省诸暨市珠力神医用品有限公司 | Silicon gel combination |
| CN107296975A (en) * | 2017-08-03 | 2017-10-27 | 江苏亿茂滤材有限公司 | A kind of antibacterial anti hemorrhagic based composite dressing for medical use and preparation method thereof |
| WO2020077923A1 (en) * | 2018-10-19 | 2020-04-23 | 中山大学 | Polypropylene/tea polyphenol patch for intraperitoneal repair, preparation method therefor and use thereof |
| CN111298199A (en) * | 2020-04-13 | 2020-06-19 | 虞连奎 | Temporary implant for orthopedics department and preparation method thereof |
| CN111298199B (en) * | 2020-04-13 | 2020-12-01 | 中国医科大学附属第一医院 | Temporary implant for orthopedics department and preparation method thereof |
| CN113332488A (en) * | 2021-05-31 | 2021-09-03 | 南昌智产科技有限公司 | Medical silica gel foam dressing and preparation method thereof |
| CN116019963A (en) * | 2022-12-02 | 2023-04-28 | 江苏弘生生物工程有限公司 | Preparation method of medical silica gel foam dressing |
| CN116019963B (en) * | 2022-12-02 | 2023-09-22 | 江苏弘生生物工程有限公司 | Preparation method of medical silica gel foam dressing |
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